Ifnar2

Summary

Gene Symbol: Ifnar2
Description: interferon (alpha and beta) receptor 2
Alias: AI747302, Ifnar-2, interferon alpha/beta receptor 2, IFN-R-2, IFN-alpha/beta receptor 2, interferon receptor 2a', interferon receptor 2c, type I interferon alpha/beta receptor 2a, type I interferon receptor 2
Species: mouse

Top Publications

  1. ncbi The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties
    M P Hardy
    Center for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Blood 97:473-82. 2001
  2. ncbi Characterization and transcriptional analysis of the mouse Chromosome 16 cytokine receptor gene cluster
    Matthew P Hardy
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Mamm Genome 14:105-18. 2003
  3. ncbi Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation
    Michael H Shaw
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02906, USA
    J Immunol 176:7263-71. 2006
  4. doi Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells
    Yutaro Kumagai
    World Premier International Immunology Frontier Research Center, Osaka University, Suita, Japan
    J Immunol 182:3960-4. 2009
  5. ncbi Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2
    C M Owczarek
    Molecular Genetics and Development Group, Institute of Reproduction and Development, Monash University, Clayton Victoria 3168, Australia
    J Biol Chem 272:23865-70. 1997
  6. ncbi Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
    Jennifer E Fenner
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Clayton 3168, Australia
    Nat Immunol 7:33-9. 2006
  7. ncbi TAM receptors are pleiotropic inhibitors of the innate immune response
    Carla V Rothlin
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cell 131:1124-36. 2007
  8. pmc B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6
    Shaun W Jackson
    Seattle Children s Research Institute, Seattle, WA 98105 Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195
    J Exp Med 213:733-50. 2016
  9. pmc Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses
    Barbara Kroczynska
    From the Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, The Department of Radiation Oncology, Northwestern University, Chicago, Illinois 60611
    J Biol Chem 291:2389-96. 2016
  10. pmc The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
    Si Ming Man
    1 Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA 2 School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia
    Nat Immunol 16:467-75. 2015

Scientific Experts

  • Edward M Behrens
  • Ken J Ishii
  • Diane Ordway
  • Tara M Strutt
  • Kazuyoshi Takeda
  • Mathias Krummen
  • Donna L Thibault
  • C M Owczarek
  • Fabrizio Mattei
  • Paul J Hertzog
  • Shizuo Akira
  • Matthew P Hardy
  • Jeremy B Swann
  • Paul Hertzog
  • Barbara Kroczynska
  • Shaun W Jackson
  • Robert D Schreiber
  • Burcu Temizoz
  • Natarajan Ayithan
  • Si Ming Man
  • Angus T Stock
  • Shamith A Samarajiwa
  • Niamh E Mangan
  • Susie Jane Braniff
  • Keiichi Ohata
  • Kouji Kobiyama
  • Nicole A de Weerd
  • Masaki Shoji
  • Andrew J Mitchell
  • Sungyong Won
  • Jayakumar S Poovassery
  • Thomas Marichal
  • Claire J Greenhill
  • Fei Ying
  • Desmond K Y Ang
  • Yutaro Kumagai
  • Courtney R Plumlee
  • Christian Schindler
  • Carolyn Lee
  • Judith Field
  • Stephanie L Day
  • Wenli Zhao
  • Jennifer Martinez
  • Andrea Schneider
  • Mark J Smyth
  • W L William Chang
  • Xiaoli Tang
  • Carla V Rothlin
  • Julien Taieb
  • John Kuchtey
  • Michael H Shaw
  • Jennifer E Fenner
  • Elizabeth M Dam
  • Tanvi Arkatkar
  • Gavin T Blyth
  • Eleanor N Fish
  • Nikita S Kolhatkar
  • Diana Saleiro
  • Holly M Jacobs
  • Leonidas C Platanias
  • Ewa M Kościuczuk
  • Robert L Rafidi
  • Swarna Mehrotra
  • Jane H Buckner
  • Zofia Warminska
  • Baidong Hou
  • Nicole E Scharping
  • Jacek Jemielity
  • Beata Majchrzak-Kita
  • David J Rawlings
  • Ahmet Dirim Arslan
  • Nao Jounai
  • Mohamed Lamkanfi
  • Taiki Aoshi
  • Thirumala Devi Kanneganti
  • Mike Bray
  • R K Subbarao Malireddi
  • Scott M Anthony
  • Peter Vogel
  • Kelly S Stuthman
  • Sina Bavari
  • Koji Ozasa
  • Etsushi Kuroda
  • Rajendra Karki
  • Masahiro Yamamoto
  • Geoffrey Neale
  • Steven B Bradfute
  • Keiko Ozato
  • Meri Najdovska
  • Vinh Phuc Nguyen

Detail Information

Publications49

  1. ncbi The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties
    M P Hardy
    Center for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Blood 97:473-82. 2001
    ..Therefore, our results suggest that soluble Ifnar-2 is an important regulator of endogenous and systemically administered type I IFN...
  2. ncbi Characterization and transcriptional analysis of the mouse Chromosome 16 cytokine receptor gene cluster
    Matthew P Hardy
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Mamm Genome 14:105-18. 2003
    ..CIICR) genes Il10r2 and Ifnar1 are localized on mouse Chr 16 in a cluster that also contains the CIICR genes Ifnar2 and Ifngr2...
  3. ncbi Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation
    Michael H Shaw
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02906, USA
    J Immunol 176:7263-71. 2006
    ..Thus, Tyk2 can be viewed as a dual-function Jak, mediating both pro and anti-inflammatory cytokine responses...
  4. doi Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells
    Yutaro Kumagai
    World Premier International Immunology Frontier Research Center, Osaka University, Suita, Japan
    J Immunol 182:3960-4. 2009
    ..These results showed that detection of viruses via TLRs together with a type I IFN feedback system circumvents the requirement for viral replication-dependent recognition in pDCs...
  5. ncbi Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2
    C M Owczarek
    Molecular Genetics and Development Group, Institute of Reproduction and Development, Monash University, Clayton Victoria 3168, Australia
    J Biol Chem 272:23865-70. 1997
    ..Northern blot analyses show that murine IFNAR 2 is expressed as two transcripts of 4 kilobases encoding the transmembrane isoform and 1...
  6. ncbi Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
    Jennifer E Fenner
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Clayton 3168, Australia
    Nat Immunol 7:33-9. 2006
    ..and IFN-beta) and mice deficient in interferon-gamma or type I interferon receptor components (IFNAR1 or IFNAR2), we demonstrate here that SOCS1 deficiency amplified type I interferon antiviral and proinflammatory actions ..
  7. ncbi TAM receptors are pleiotropic inhibitors of the innate immune response
    Carla V Rothlin
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cell 131:1124-36. 2007
    ....
  8. pmc B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6
    Shaun W Jackson
    Seattle Children s Research Institute, Seattle, WA 98105 Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195
    J Exp Med 213:733-50. 2016
    ..Our combined findings identify a novel B cell-intrinsic mechanism whereby IFN signals promote lupus pathogenesis, implicating this pathway as a potential therapeutic target in SLE. ..
  9. pmc Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses
    Barbara Kroczynska
    From the Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, The Department of Radiation Oncology, Northwestern University, Chicago, Illinois 60611
    J Biol Chem 291:2389-96. 2016
    ..Together, our findings establish a central role for mTORC2 in IFNγ signaling and type II IFN responses. ..
  10. pmc The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
    Si Ming Man
    1 Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA 2 School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia
    Nat Immunol 16:467-75. 2015
    ..Our results reveal a specific requirement for IRF1 and GBPs in the liberation of DNA for sensing by AIM2 depending on the pathogen encountered by the cell. ..
  11. pmc Virus-like particles activate type I interferon pathways to facilitate post-exposure protection against Ebola virus infection
    Natarajan Ayithan
    Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, United States of America
    PLoS ONE 10:e0118345. 2015
    ..Together, this study indicates that VLPs afford post-exposure protection by promoting expeditious initiation of type I IFN signaling in the host. ..
  12. pmc TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN
    Burcu Temizoz
    Laboratory of Vaccine Science, WPI Immunology Frontier Research Center IFReC, Osaka University, Osaka, Japan
    Eur J Immunol 45:1159-69. 2015
    ..Thus, the combination of CpG ODN and a STING ligand may offer therapeutic application as a potent type-II IFN inducer. ..
  13. pmc Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection
    Angus T Stock
    Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 211:751-9. 2014
    ..Overall, our findings describe a novel role for IFN in the direct, and selective, inhibition of Cxcr2 chemokine ligands, which results in the inhibition of neutrophil recruitment to neuronal tissue. ..
  14. doi Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock
    Shamith A Samarajiwa
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    J Immunol 192:4425-35. 2014
    ..vivo importance of the soluble type I IFNAR, soluble (s)IFNAR2a, which is generated by alternative splicing of the Ifnar2 gene...
  15. doi Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1
    Nicole A de Weerd
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Nat Immunol 14:901-7. 2013
    ..All interferons are considered to signal via the heterodimeric IFNAR1-IFNAR2 complex, yet some subtypes such as interferon-β (IFN-β) can exhibit distinct functional properties, although the ..
  16. doi TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
    Ken J Ishii
    Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency JST
    Nature 451:725-9. 2008
    ..These data suggest that TBK1 is a key signalling molecule for DNA-vaccine-induced immunogenicity, by differentially controlling DNA-activated innate immune signalling through haematopoietic and non-haematopoietic cells...
  17. ncbi Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Immunol 178:6268-79. 2007
    ..We propose that CR3 provides a "nondanger" signal that suppresses the stimulatory capacity of DCs...
  18. doi Type I IFN protects against antigen-induced arthritis
    Fei Ying
    Affiliated Hospital of Guiyang Medical College, Department of Microbiology and Immunology, Guiyang, Guizhou, P R China
    Eur J Immunol 41:1687-95. 2011
    ..In conclusion, we demonstrate that type I IFN can prevent joint inflammation by downregulating antigen-specific cellular immunity...
  19. pmc Increased susceptibility to DNA virus infection in mice with a GCN2 mutation
    Sungyong Won
    Department of Genetics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Virol 86:1802-8. 2012
    ..Importantly, homozygous Eif2ak4(atc) mice showed a modest increase in susceptibility to MCMV infection, demonstrating that translational arrest dependent on GCN2 contributes to the antiviral response in vivo...
  20. doi Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms
    Jayakumar S Poovassery
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 189:1757-64. 2012
    ..These new findings reveal distinct and overlapping signaling mechanisms used by BCR and IFNAR in the regulation of TLR7 tolerance and activation...
  21. doi Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis
    Andrew J Mitchell
    Sydney Medical School, University of Sydney, Camperdown, New South Wales 2050, Australia
    J Immunol 189:4970-80. 2012
    ..Together, these data suggest that inflammasome-dependent IFN-γ contributes via multiple pathways to pathology during S. pneumoniae meningitis...
  22. doi Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa
    Masaki Shoji
    Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Biochem Biophys Res Commun 425:89-93. 2012
    ..m. Adv vaccination. We show that type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell response in the gut-mucosal compartment following the i.m. Adv vaccination...
  23. pmc Memory CD4+ T cells induce innate responses independently of pathogen
    Tara M Strutt
    Trudeau Institute, Saranac Lake, New York, USA
    Nat Med 16:558-64, 1p following 564. 2010
    ..This represents a previously undescribed mechanism by which memory CD4(+) T cells induce an early innate response that enhances immune protection against pathogens...
  24. ncbi Type I IFN contributes to NK cell homeostasis, activation, and antitumor function
    Jeremy B Swann
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, 8006 Victoria, Australia
    J Immunol 178:7540-9. 2007
    ..Using both IFNAR1- and IFNAR2-deficient mice, as well as an IFNAR1-blocking Ab, we demonstrate that endogenous type I IFN is critical for ..
  25. doi IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
    Claire J Greenhill
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    J Immunol 186:1199-208. 2011
    ....
  26. doi IFN-γ production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Leukoc Biol 90:777-85. 2011
    ..Our results demonstrate that IFN-γ production from lung resident NK cells is a key response in the natural resistance to the experimental lung metastasis of NK cell-resistant tumor cells...
  27. doi DNA released from dying host cells mediates aluminum adjuvant activity
    Thomas Marichal
    Laboratory of Cellular and Molecular Physiology, Groupe Interdisciplinaire de Genoproteomique Appliquee, University of Liege, Liege, Belgium
    Nat Med 17:996-1002. 2011
    ....
  28. ncbi A novel dendritic cell subset involved in tumor immunosurveillance
    Julien Taieb
    ERM0208 INSERM, Faculté de Médecine Kremlin Bicêtre, Institut Gustave Roussy, Villejuif, France
    Nat Med 12:214-9. 2006
    ..In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response...
  29. ncbi A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    Ken J Ishii
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 7:40-8. 2006
    ..These results suggest that both TBK1 and IKKi are required for innate immune activation by B-DNA, which might be important in antiviral innate immunity and other DNA-associated immune disorders...
  30. pmc Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression
    Matthew P Hardy
    Center for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria 3168, Australia
    Biochem J 365:355-67. 2002
    ....
  31. ncbi Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling
    Vinh Phuc Nguyen
    Department of Pathology and the Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 277:9713-21. 2002
    The interferon-alpha (IFNalpha) receptor consists of two subunits, the IFNalpha receptor 1 (IFNaR1) and 2 (IFNaR2) chains. Following ligand binding, IFNaR1 is phosphorylated on tyrosine 466, and this site recruits Stat2 via its SH2 domain...
  32. ncbi Identification of tooth-specific downstream targets of Runx2
    J S Gaikwad
    Department of Orthodontics, Dental Branch, University of Texas at Houston Health Science Center, Houston, TX 77030, USA
    Gene 279:91-7. 2001
    ..In conclusion, we have successfully generated a library enriched in genes expressed in Runx2(+/+) molar tooth organs and performed preliminary studies to assess the role of Zfp in tooth development...
  33. ncbi Mammalian type I interferon receptors consists of two subunits: IFNaR1 and IFNaR2
    S H Kim
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Gene 196:279-86. 1997
    ..We therefore conclude that the murine type I IFN receptor consists of two different subunits--a configuration shared by humans, and probably all other mammals...
  34. doi Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy
    Mathias Krummen
    Department of Dermatology, University of Mainz, Mainz, Germany
    J Leukoc Biol 88:189-99. 2010
    ..Finally, we show that synergy is partially dependent on IFNAR signaling but does not require the release of IFNs to the enviroment, suggesting an autocrine action of type I IFNs...
  35. ncbi Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals
    W L William Chang
    Center for Comparative Medicine and
    J Immunol 178:1457-67. 2007
    ....
  36. ncbi The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 179:522-31. 2007
    ..This association may explain the paradoxical initial emergence of a TH1 response in these mice but their relatively short time of survival...
  37. ncbi Acetylation-dependent signal transduction for type I interferon receptor
    Xiaoli Tang
    Department of Surgery, Brown University Medical School, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Cell 131:93-105. 2007
    ..These results have significant implications concerning the central role of acetylation in cytokine receptor signal transduction...
  38. pmc Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
    Jeremy B Swann
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Proc Natl Acad Sci U S A 105:652-6. 2008
    ..Overall, these data not only confirm the key role that MyD88 plays in promoting tumor development but also demonstrate that inflammation-induced carcinogenesis and cancer immunoediting can indeed occur in the same mouse tumor model...
  39. ncbi Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo
    Jennifer Martinez
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:1592-7. 2008
    ..Our findings may help design effective strategies for the control of poxviral infections in vivo...
  40. pmc Interferon-alphabeta mediates partial control of early pulmonary Mycobacterium bovis bacillus Calmette-Guérin infection
    John Kuchtey
    Institute of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106 4984, USA
    Immunology 118:39-49. 2006
    ..These findings suggest that IFN-alphabeta contributes to innate immunity to pulmonary mycobacterial infection by augmenting production of nitric oxide...
  41. ncbi A conserved IFN-alpha receptor tyrosine motif directs the biological response to type I IFNs
    Wenli Zhao
    Department of Microbiology, Columbia University, New York, NY 10032, USA
    J Immunol 180:5483-9. 2008
    ..biological activities through an evolutionarily conserved IFN-alpha receptor (IFNAR), consisting of IFNAR1 and IFNAR2. These two chains direct the rapid activation of two founding members of the STAT family of transcription factors, ..
  42. ncbi Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy
    Stephanie L Day
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 180:7158-66. 2008
    ..Our data also indicate that while IFN-epsilon exhibits certain biological traits similar to other type I IFNs, it may also have a specific role in mucosal immune regulation that is quite distinct...
  43. doi GM-CSF-induced autoimmune gastritis in interferon alpha receptor deficient mice
    Judith Field
    Department of Medicine, Monash University, Clayton, Victoria 3168, Australia
    J Autoimmun 31:274-80. 2008
    ..To address this, we crossed PC-GMCSF transgenic mice with mice deficient in interferon alpha (IFNalpha) receptor2 (IFNAR2). We found that EAG development in the PC-GMCSF transgenic mice was not affected by IFNAR2 deficiency...
  44. doi Selective contribution of Tyk2 to cell activation by lipopolysaccharide
    Andrea Schneider
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Veterinaerplatz 1, A 1210 Vienna, Austria
    FEBS Lett 582:3681-6. 2008
    ..The data suggest a selective contribution of Tyk2 to the activation of inflammation-relevant cell types by LPS...
  45. doi Type I IFN regulate DC turnover in vivo
    Fabrizio Mattei
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 39:1807-18. 2009
    ....
  46. pmc Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus
    Donna L Thibault
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA
    Arthritis Res Ther 11:R112. 2009
    ..In the current study, we characterized the role of the IFNAR2 chain of the type I IFN (IFN-I) receptor in the targeting of nucleic acid-associated autoantigens and in B-cell ..
  47. pmc Interferons direct an effective innate response to Legionella pneumophila infection
    Courtney R Plumlee
    Department of Biological Sciences, Columbia University, New York, New York 10032, USA
    J Biol Chem 284:30058-66. 2009
    ..pneumophila. Surprisingly, this suppression is mediated by a pathway that is independent of Stat1, Stat2, Stat3, but correlates with the polarization of macrophages toward the M1 or classically activated phenotype...
  48. doi Cutting edge: pulmonary Legionella pneumophila is controlled by plasmacytoid dendritic cells but not type I IFN
    Desmond K Y Ang
    Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia
    J Immunol 184:5429-33. 2010
    ..The ability of pDCs to combat infection did not require type I IFN. This study points to an unappreciated role for pDCs in combating bacterial infections and indicates a novel mechanism of action for this cell type...
  49. ncbi Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice
    A M Beebe
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    Immunity 6:551-7. 1997
    ..The presence of all six loci was not necessary to confer resistance and no single locus was required. Rather, a variety of combinations of these loci may be capable of interacting to confer resistance...