Ido2

Summary

Gene Symbol: Ido2
Description: indoleamine 2,3-dioxygenase 2
Alias: AI265623, C230043N17Rik, Ido-2, Indol1, indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase-like protein 1, indoleamine-pyrrole 2,3 dioxygenase-like 1
Species: mouse

Top Publications

  1. ncbi Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice
    Helen J Ball
    Discipline of Pathology and Bosch Institute, University of Sydney, NSW 2006, Australia
    Gene 396:203-13. 2007
  2. ncbi Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan
    Richard Metz
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 67:7082-7. 2007
  3. pmc Investigation of the kynurenine pathway in Indoleamine 2, 3 dioxygenase deficient mice with inflammatory arthritis
    Lukasz Kolodziej
    The Kennedy Institute of Rheumatology Division, Imperial College London, Arthritis Research UK Building, Charing Cross Hospital Campus, 65 Aspenlea Road, London, W6 8LH, UK
    Transgenic Res 22:1049-54. 2013
  4. doi Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease
    Gelareh Mazarei
    Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 127:852-67. 2013
  5. pmc IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation
    Richard Metz
    New Link Genetics Corporation, Ames, IA 50010, USA
    Int Immunol 26:357-67. 2014
  6. pmc IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis
    Lauren M F Merlo
    Lankenau Institute for Medical Research, Wynnewood, PA 19096
    J Immunol 192:2082-90. 2014
  7. doi The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis
    Lay Khoon Too
    Molecular Immunopathology Unit, Bosch Institute and School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Behav Brain Res 270:179-95. 2014
  8. pmc Aryl hydrocarbon receptor control of a disease tolerance defence pathway
    Alban Bessede
    1 Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy 2 IMS Laboratory, University of Bordeaux, 33607 Pessac, France 3
    Nature 511:184-90. 2014
  9. doi Differential expression and regulation of Ido2 in the mouse uterus during peri-implantation period
    Dang Dang Li
    College of Veterinary Medicine, Jilin University, Changchun, People s Republic of China
    In Vitro Cell Dev Biol Anim 51:264-72. 2015
  10. doi Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway
    Helen J Ball
    Discipline of Pathology and Bosch Institute, University of Sydney, Camperdown, NSW 2006, Australia
    Int J Biochem Cell Biol 41:467-71. 2009

Scientific Experts

  • Lukasz Kolodziej
  • Richard Metz
  • George C Prendergast
  • James B DuHadaway
  • Helen J Ball
  • Lauren M F Merlo
  • Nicholas H Hunt
  • Alexander J Muller
  • Dang Dang Li
  • Lay Khoon Too
  • Laura Mandik-Nayak
  • Toshikazu Nakamura
  • Hiroshi Funakoshi
  • Alban Bessede
  • Elizabeth Pigott
  • Gelareh Mazarei
  • Andrew L Mellor
  • Masakazu Fukunaga
  • Senad Divanovic
  • James A McQuillan
  • Christopher J D Austin
  • Silvia Weiser
  • Jessica B Katz
  • Bin Guo
  • Zhan Peng Yue
  • Hang Cao
  • Liang Yue
  • Chuan Hui Guo
  • Zhan qing Yang
  • Xin Yuan Liu
  • Rossana Iannitti
  • Emilia M C Mazza
  • Carmine Vacca
  • Alfonso Iorio
  • David Gilot
  • Teresa Zelante
  • Ursula Grohmann
  • Danilo Piobbico
  • Babak Baban
  • Cinzia Brunacci
  • Roberta Bianchi
  • Maria T Pallotta
  • Masaaki Kanai
  • Giuseppe Servillo
  • Luciana Tissi
  • Maria L Belladonna
  • Gilles J Guillemin
  • Martin P Keough
  • Marco Gargaro
  • Tobias V Lanz
  • Maria A Della Fazia
  • Matteo Pirro
  • Paolo Puccetti
  • Michael Platten
  • Luigina Romani
  • Phillip Chandler
  • Ciriana Orabona
  • Iain S McGregor
  • Courtney Smith
  • Francesca Fallarino
  • Samantha Grabler
  • Silvio Bicciato
  • Davide Matino
  • Michael S Denison
  • Claudia Volpi
  • Sonja Rust
  • Michel Geffard
  • Louis Boon
  • Antonio Macchiarulo
  • Bernard Veyret
  • Ge Lu
  • David P Budac
  • Thomas Moller
  • Emma S Tomlinson Guns
  • Hans Adomat
  • Blair R Leavitt
  • Moshe Arditi
  • George S Yap
  • Kenichi Shimada
  • Andrea M Cooper
  • Nancy M Sawtell
  • Jamie I Warning
  • David H Munn
  • Aurelien Trompette
  • Yasuko Yamamoto
  • Christopher L Karp
  • Yuko Arioka
  • Randall J Basaraba
  • Yuki Murakami
  • Kuniaki Saito

Detail Information

Publications14

  1. ncbi Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice
    Helen J Ball
    Discipline of Pathology and Bosch Institute, University of Sydney, NSW 2006, Australia
    Gene 396:203-13. 2007
    ..We describe the discovery of another enzyme with this activity, indoleamine 2,3-dioxygenase-like protein (INDOL1), which is closely related to INDO and is expressed in mice and humans...
  2. ncbi Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan
    Richard Metz
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 67:7082-7. 2007
    ..Here, we report the discovery of a novel IDO-related tryptophan catabolic enzyme termed IDO2 that is preferentially inhibited by D-1MT...
  3. pmc Investigation of the kynurenine pathway in Indoleamine 2, 3 dioxygenase deficient mice with inflammatory arthritis
    Lukasz Kolodziej
    The Kennedy Institute of Rheumatology Division, Imperial College London, Arthritis Research UK Building, Charing Cross Hospital Campus, 65 Aspenlea Road, London, W6 8LH, UK
    Transgenic Res 22:1049-54. 2013
    ..In the immune system, two distinct enzymes, Indoleamne 2,3 dioxygenase 1 (IDO1) and Indoleamine 2, 3 dioxygenase 2 (IDO2) can initiate metabolic flux through the kynurenine pathway...
  4. doi Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease
    Gelareh Mazarei
    Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 127:852-67. 2013
    ..Striatally specific induction of Ido1 and downstream KP alterations suggest involvement in HD pathogenesis, and should be taken into account in future therapeutic developments for HD...
  5. pmc IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation
    Richard Metz
    New Link Genetics Corporation, Ames, IA 50010, USA
    Int Immunol 26:357-67. 2014
    b>IDO2 is implicated in tryptophan catabolism and immunity but its physiological functions are not well established...
  6. pmc IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis
    Lauren M F Merlo
    Lankenau Institute for Medical Research, Wynnewood, PA 19096
    J Immunol 192:2082-90. 2014
    ..In this article, we examine the effect of two different IDO enzymes, IDO1 and IDO2, on the development of autoimmune arthritis in the KRN preclinical model of rheumatoid arthritis...
  7. doi The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis
    Lay Khoon Too
    Molecular Immunopathology Unit, Bosch Institute and School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Behav Brain Res 270:179-95. 2014
    ....
  8. pmc Aryl hydrocarbon receptor control of a disease tolerance defence pathway
    Alban Bessede
    1 Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy 2 IMS Laboratory, University of Bordeaux, 33607 Pessac, France 3
    Nature 511:184-90. 2014
    ..The resulting endotoxin-tolerant state was found to protect mice against immunopathology in Gram-negative and Gram-positive infections, pointing to a role for AhR in contributing to host fitness. ..
  9. doi Differential expression and regulation of Ido2 in the mouse uterus during peri-implantation period
    Dang Dang Li
    College of Veterinary Medicine, Jilin University, Changchun, People s Republic of China
    In Vitro Cell Dev Biol Anim 51:264-72. 2015
    b>Ido2 is involved in tryptophan catabolism and immunity, but its physiological functions remain poorly understood...
  10. doi Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway
    Helen J Ball
    Discipline of Pathology and Bosch Institute, University of Sydney, Camperdown, NSW 2006, Australia
    Int J Biochem Cell Biol 41:467-71. 2009
    ..2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein or proto-indoleamine 2,3-dioxygenase (IDO2, IDO-2, INDOL1 or proto-IDO), with this activity recently has been described...
  11. doi Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape
    Jessica B Katz
    Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    Immunol Rev 222:206-21. 2008
    ....
  12. pmc Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection
    Senad Divanovic
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, and the University of Cincinnati College of Medicine, Ohio, USA
    J Infect Dis 205:152-61. 2012
    ..Thus, IDO plays biologically important roles in the host response to diverse intracellular infections, but the dominant nature of this role--antimicrobial or immunoregulatory--is pathogen-specific...
  13. pmc Studies on tissue and cellular distribution of indoleamine 2,3-dioxygenase 2: the absence of IDO1 upregulates IDO2 expression in the epididymis
    Masakazu Fukunaga
    Human Health Sciences, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Japan
    J Histochem Cytochem 60:854-60. 2012
    ..Recently, in addition to IDO1, a new isoform called IDO2 was identified...