Ido1

Summary

Gene Symbol: Ido1
Description: indoleamine 2,3-dioxygenase 1
Alias: Ido, Indo, indoleamine 2,3-dioxygenase 1, IDO-1, indole 2,3-dioxygenase, indoleamine-pyrrole 2,3 dioxygenase
Species: mouse

Top Publications

  1. ncbi Prevention of allogeneic fetal rejection by tryptophan catabolism
    D H Munn
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 281:1191-3. 1998
  2. ncbi Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06122, Italy
    Int Immunol 14:65-8. 2002
  3. ncbi Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 168:3771-6. 2002
  4. ncbi Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection
    Maria Friberg
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Int J Cancer 101:151-5. 2002
  5. ncbi Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion
    Andrew L Mellor
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 171:1652-5. 2003
  6. ncbi Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    Catherine Uyttenhove
    Ludwig Institute for Cancer Research and Cellular Genetics Unit, Universite de Louvain, B 1200 Brussels, Belgium
    Nat Med 9:1269-74. 2003
  7. ncbi Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific
    Babak Baban
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia 1120, 15th Street, Augusta, GA 30912 2600, USA
    J Reprod Immunol 61:67-77. 2004
  8. pmc Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    David H Munn
    Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 114:280-90. 2004
  9. ncbi Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase
    Andrew L Mellor
    Department of Medicine, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912 2600, USA
    Int Immunol 16:1391-401. 2004
  10. ncbi Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis
    Mikito Ito
    Genox Research Inc, Ibaraki, Japan
    J Dermatol Sci 36:157-64. 2004

Research Grants

Scientific Experts

Detail Information

Publications111 found, 100 shown here

  1. ncbi Prevention of allogeneic fetal rejection by tryptophan catabolism
    D H Munn
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 281:1191-3. 1998
    ..concepti occurred when pregnant mice were treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme expressed by trophoblasts and macrophages...
  2. ncbi Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06122, Italy
    Int Immunol 14:65-8. 2002
    ..proliferation by macrophage tryptophan catabolism involving the activity of the enzyme indoleamine 2,3-dioxygenase (IDO)...
  3. ncbi Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 168:3771-6. 2002
    Pharmacological inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine gestation results in fetal allograft rejection and blocks the ability of murine CD8(+) dendritic cells to suppress delayed-type hypersensitivity ..
  4. ncbi Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection
    Maria Friberg
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Int J Cancer 101:151-5. 2002
    ..We report on evidence that the expression of the immunosuppressive enzyme, indoleamine 2,3-dioxygenase (IDO) by mononuclear cells that invade tumors and tumor-draining lymph nodes, is 1 mechanism that may account for this ..
  5. ncbi Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion
    Andrew L Mellor
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 171:1652-5. 2003
    ..In this study, we show that expression of the tryptophan-degrading enzyme indoleamine 2,3 dioxygenase (IDO) is selectively induced in specific splenic DC subsets when mice were exposed to the synthetic immunomodulatory ..
  6. ncbi Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    Catherine Uyttenhove
    Ludwig Institute for Cancer Research and Cellular Genetics Unit, Universite de Louvain, B 1200 Brussels, Belgium
    Nat Med 9:1269-74. 2003
    ..proliferation arrest when exposed to tryptophan shortage, which can be provoked by indoleamine 2,3-dioxygenase (IDO), an enzyme that is expressed in placenta and catalyzes tryptophan degradation...
  7. ncbi Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific
    Babak Baban
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia 1120, 15th Street, Augusta, GA 30912 2600, USA
    J Reprod Immunol 61:67-77. 2004
    Pharmacologic inhibition of indoleamine 2,3 dioxygenase (IDO) activity during murine pregnancy results in rejection of allogeneic fetuses by the maternal immune system...
  8. pmc Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    David H Munn
    Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 114:280-90. 2004
    ..DCs (pDCs) that constitutively expressed immunosuppressive levels of the enzyme indoleamine 2,3-dioxygenase (IDO). Despite comprising only 0...
  9. ncbi Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase
    Andrew L Mellor
    Department of Medicine, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912 2600, USA
    Int Immunol 16:1391-401. 2004
    Murine dendritic cells (DCs) expressing indoleamine 2,3 dioxygenase (IDO) catabolize tryptophan and can suppress T cell responses elicited in vivo...
  10. ncbi Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis
    Mikito Ito
    Genox Research Inc, Ibaraki, Japan
    J Dermatol Sci 36:157-64. 2004
    ..Atopic dermatitis (AD) and psoriasis are common inflammatory skin diseases. Although many reports implicate Th2 cytokines in the pathophysiology of AD and Th1 cytokines in psoriasis, the precise etiology of these diseases remains elusive...
  11. ncbi Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
    Alexander J Muller
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Nat Med 11:312-9. 2005
    ..Elevation of the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) in tumor cells can facilitate immune escape...
  12. ncbi GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
    David H Munn
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunity 22:633-42. 2005
    Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-expressing immunoregulatory dendritic cells (DCs) have been implicated in settings including tumors, autoimmunity, and transplant tolerance...
  13. ncbi A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation
    Babak Baban
    Immunotherapy Center, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912, USA
    Int Immunol 17:909-19. 2005
    ..CTLA4-Ig (soluble synthetic CTLA4 fusion protein) induces expression of the enzyme indoleamine 2,3-dioxygenase (IDO) in some dendritic cells (DCs), which acquire potent T cell regulatory functions as a consequence...
  14. ncbi Bacille Calmette-Guérin inoculation induces chronic activation of peripheral and brain indoleamine 2,3-dioxygenase in mice
    Maite Moreau
    Laboratory of Neurobiologie Integrative, Formation de Recherche en Evolution 2723 Centre National de la Recherche Scientifique Unite Mixte de Recherche 1244 Institut National de Recherche Agronomique, Institut Francois Magendie, Bordeaux, France
    J Infect Dis 192:537-44. 2005
    Activation of the indoleamine 2,3-dioxygenase (IDO) enzyme and the resulting decrease in plasma tryptophan (TRP) levels appears to be a crucial link in the relationship between cytokines and depression...
  15. ncbi Indoleamine 2,3 dioxygenase and regulation of T cell immunity
    Andrew Mellor
    Immunotherapy Center, Medical College of Georgia, 1120, 15th St, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 338:20-4. 2005
    ..supports the hypothesis that specialized subsets of dendritic cells expressing indoleamine 2,3 dioxygenase (IDO), which catalyzes oxidative catabolism of tryptophan, play critical roles in regulation of T cell-mediated immune ..
  16. ncbi Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling
    Andrew L Mellor
    Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 175:5601-5. 2005
    ..Paradoxically, expression of the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is induced following i.v. CpG-ODN administration to mice...
  17. ncbi Toward the identification of a tolerogenic signature in IDO-competent dendritic cells
    Ciriana Orabona
    Section of Pharmacology, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Blood 107:2846-54. 2006
    ..by interferon-gamma (IFN-gamma), which activates the enzyme indoleamine 2,3-dioxygenase (IDO, encoded by Indo) and thus initiates the immunosuppressive pathway of tryptophan catabolism...
  18. ncbi Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia
    Koenraad F Van Der Sluijs
    Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 193:214-22. 2006
    ..with influenza virus induces local expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO), which has been shown to enhance inflammatory mediator responses in vitro...
  19. ncbi Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO
    Maria L Belladonna
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    J Immunol 177:130-7. 2006
    ..However, there are features of this mechanism, initiated by IDO, that are still unclear, including the role of enzymes that are downstream of IDO in the kynurenine pathway and the ..
  20. ncbi Cell-autonomous control of interferon type I expression by indoleamine 2,3-dioxygenase in regulatory CD19+ dendritic cells
    Anna K Manlapat
    Immunotherapy and Cancer Centers, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Eur J Immunol 37:1064-71. 2007
    ..T cell regulatory functions due to induced expression of the intracellular enzyme indoleamine 2,3-dioxygenase (IDO), which catabolizes tryptophan. In CD19(+) DC, IFN type I (IFN-alpha) is the obligate inducer of IDO...
  21. ncbi Suppression of memory CD8 T cell generation and function by tryptophan catabolism
    Zhiwei Liu
    Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    J Immunol 178:4260-6. 2007
    Dendritic cell-derived indoleamine 2,3-dioxygenase (IDO) suppresses naive T cell proliferation and induces their apoptosis by catalyzing tryptophan, and hence is essential for the maintenance of peripheral tolerance...
  22. ncbi Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes
    Maria Laura Belladonna
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Transplantation 84:S17-20. 2007
    Tryptophan catabolism occurring in dendritic cells (DCs) and initiated by indoleamine 2,3-dioxygenase (IDO) is an emerging major mechanism of peripheral tolerance...
  23. ncbi Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan
    Richard Metz
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 67:7082-7. 2007
    Small-molecule inhibitors of indoleamine 2,3-dioxygenase (IDO) are currently being translated to clinic for evaluation as cancer therapeutics...
  24. pmc Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
    Madhav D Sharma
    Department of Pediatrics, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 117:2570-82. 2007
    ..DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). We show that these IDO+ pDCs directly activate resting CD4+CD25+Foxp3+ Tregs for potent suppressor activity...
  25. ncbi Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism
    Paolo Puccetti
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Blood Cells Mol Dis 40:101-5. 2008
    ..have been credited with a unique ability to express the inducible, tolerogenic enzyme indoleamine 2,3-dioxygenase (IDO) as an effector means of regulatory T cell function and thus mediate immunosuppression in specific settings...
  26. ncbi Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival
    Jianping Li
    Centre Hospitalier Universitaire Vaudois, BH10, Lausanne 1011, Switzerland
    Am J Physiol Heart Circ Physiol 293:H3415-23. 2007
    Cells that express indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in the catabolism of tryptophan, suppress T cell responses and promote immunological tolerance...
  27. ncbi Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc
    Antonella De Luca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 179:5999-6008. 2007
    ..was modulated by induced Treg cells, which required the TRIF pathway as well, and acted through activation of IDO in dendritic cells and Th17 cell antagonism...
  28. pmc Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model
    Min Jung Park
    The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Banpo dong, Seocho Gu, Seoul 137 701, South Korea
    Arthritis Res Ther 10:R11. 2008
    The present study was devised to understand the role of systemic indoleamine 2,3-dioxygenase (IDO) in the tolerance induction for orally tolerized mice in collagen-induced arthritis (CIA)...
  29. doi Suppression of cytotoxic and proliferative xenogeneic T-cell responses by transgenic expression of indoleamine 2,3-dioxygenase
    Janet Lye Keng Wee
    Faculty of Veterinary Science, Veterinary Preclinical Centre, The University of Melbourne, Parkville, Australia
    Immunol Cell Biol 86:460-5. 2008
    Tryptophan catabolism initiated by the enzyme indoleamine 2,3-dioxygenase (IDO) has been postulated to be a natural regulatory mechanism for T cells...
  30. pmc Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis
    Lynne Harrington
    Mucosal Immunology Laboratory, Pediatric Gastroenterology Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Infect Immun 76:3045-53. 2008
    Indoleamine 2,3-dioxygenase (IDO) is a negative regulator of lymphocyte responses that is expressed predominantly in macrophages and dendritic cells...
  31. doi Gene delivery of indoleamine 2,3-dioxygenase prolongs cardiac allograft survival by shaping the types of T-cell responses
    Guang Yu
    Department of Immunology, Laboratory of Transplantation, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    J Gene Med 10:754-61. 2008
    We investigated the hypothesis that overexpression of indoleamine 2,3-dioxygenase (IDO) by a cardiac allograft may result in a survival advantage of the allograft by creating a tolerogenic microenvironment.
  32. pmc Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase
    Alexander J Muller
    Immunotherapy and Cancer Centers, Flow Cytometry Core Facility, and Departments of Pediatrics and Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 105:17073-8. 2008
    ..plasmacytoid dendritic cells (pDCs) in local draining lymph nodes (dLNs) to express indoleamine 2,3 dioxygenase (IDO), which confers T cell suppressor activity on pDCs...
  33. pmc Mouse pancreatic islets are resistant to indoleamine 2,3 dioxygenase-induced general control nonderepressible-2 kinase stress pathway and maintain normal viability and function
    Reza B Jalili
    Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Pathol 174:196-205. 2009
    ..Indoleamine 2,3-dioxygenase (IDO), a tryptophan degrading enzyme, is a potent immunomodulatory factor...
  34. pmc Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior
    Jason C O'Connor
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Immunol 182:3202-12. 2009
    Chronic inflammation activates the tryptophan-degrading enzyme IDO, which is well known to impair T cell proliferation...
  35. pmc Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes
    Madhav D Sharma
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Blood 113:6102-11. 2009
    The immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by a subset of murine plasmacytoid DCs (pDCs) in tumor-draining lymph nodes (TDLNs), where it can potently activate Foxp3+ regulatory T cells (Tregs)...
  36. pmc Infectious tolerance via the consumption of essential amino acids and mTOR signaling
    Stephen P Cobbold
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 106:12055-60. 2009
    ..Inhibition of the mTOR pathway by limiting EAAs, or by specific inhibitors, induces the Treg-specific transcription factor forkhead box P3, which depends on both T cell receptor activation and synergy with TGF-beta...
  37. pmc IDO activates regulatory T cells and blocks their conversion into Th17-like T cells
    Babak Baban
    Immunotherapy and Cancer Centers, Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 183:2475-83. 2009
    ..by a rare population of plasmacytoid dendritic cells (CD19(+) pDC) induced to express the immunosuppressive enzyme IDO after TLR9 ligation...
  38. pmc Indoleamine 2,3-dioxygenase tissue distribution and cellular localization in mice: implications for its biological functions
    Xiangchen Dai
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, MS 1018, Room KLSIC 4061, 2146 W 39 Ave, Kansas City, KS 66160, USA
    J Histochem Cytochem 58:17-28. 2010
    Earlier studies have suggested that indoleamine 2,3-dioxygenase (IDO) has a wide tissue distribution in mammals...
  39. pmc Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis
    Ludovic Desvignes
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 31:974-85. 2009
    ..earlier mortality and higher bacterial burdens than control mice, underexpressed indoleamine-2,3-dioxygenase (Ido1) in lung endothelium and epithelium, and overexpressed interleukin-17 (IL-17) with massive neutrophilic ..
  40. pmc Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate
    Alexander J Muller
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 70:1845-53. 2010
    ..Ethyl pyruvate was ineffective at suppressing tumor outgrowth in both athymic and Ido1-deficient mice, providing in vivo corroboration of the importance of T-cell-dependent immunity and IDO targeting ..
  41. pmc Kynurenine is an endothelium-derived relaxing factor produced during inflammation
    Yutang Wang
    Centre for Vascular Research, School of Medical Sciences Pathology and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, Australia
    Nat Med 16:279-85. 2010
    ..Here we show that metabolism of tryptophan to kynurenine by indoleamine 2,3-dioxygenase (Ido) expressed in endothelial cells contributes to arterial vessel relaxation and the control of blood pressure...
  42. pmc B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase
    Burles A Johnson
    Immunotherapy and Cancer Centers, Departments of Pathology and Medicine, and Flow Cytometry Core Facility, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 107:10644-8. 2010
    ..the B-cell marker CD19 is uniquely competent to express the T-cell regulatory enzyme indoleamine 2,3-dioxygenase (IDO) in mice treated with TLR9 ligands (CpGs)...
  43. pmc Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures
    Xin Fu
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Neuroinflammation 7:43. 2010
    ..LPS) activates peripheral and central expression of the tryptophan degrading enzyme indoleamine 2,3 dioxygenase (IDO) which mediates depressive-like behavior...
  44. doi The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse
    Masato Hoshi
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu City, Gifu Prefecture, Japan
    J Immunol 185:3305-12. 2010
    ..Because modulation of IDO activities after viral infection may have great impact on disease progression, we investigated the role of IDO ..
  45. doi Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model
    Hiroyasu Ito
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    J Immunol 185:4554-60. 2010
    b>IDO converts tryptophan to l-kynurenine, and it is noted as a relevant molecule in promoting tolerance and suppressing adaptive immunity. In this study, we examined the effect of IDO in α-galactosylceramide (α-GalCer)-induced hepatitis...
  46. pmc Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state
    Aicha Jrad-Lamine
    GReD, CNRS UMR 6247 INSERM U931, Clermont Universite, 24 avenue des Landais, BP 80026, 63171 Aubière Cedex, France
    J Biol Chem 286:8030-42. 2011
    ..To gain insight into the role of IDO in the physiology of the mammalian epididymis, we studied both wild type and Ido1(-/-)-deficient mice...
  47. pmc HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner
    Xin Fu
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Neuroinflammation 8:88. 2011
    We have established that activation of the tryptophan degrading enzyme indoleamine 2,3 dioxygenase (IDO) mediates the switch from cytokine-induced sickness behavior to depressive-like behavior...
  48. pmc Physiologic control of IDO competence in splenic dendritic cells
    Babak Baban
    Department of Oral Biology, Georgia Health Sciences University, Augusta, GA 30912, USA
    J Immunol 187:2329-35. 2011
    Dendritic cells (DCs) competent to express the regulatory enzyme IDO in mice are a small but distinctive subset of DCs...
  49. pmc Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection
    Senad Divanovic
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, and the University of Cincinnati College of Medicine, Ohio, USA
    J Infect Dis 205:152-61. 2012
    ..physiological and pathophysiological roles for the tryptophan-degrading enzyme indolamine 2,3-dioxygenase (IDO) in immune counterregulation...
  50. doi A distinct tolerogenic subset of splenic IDO(+)CD11b(+) dendritic cells from orally tolerized mice is responsible for induction of systemic immune tolerance and suppression of collagen-induced arthritis
    Min Jung Park
    The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Banpo dong, Seocho Gu, Seoul 137 701, South Korea
    Cell Immunol 278:45-54. 2012
    ..In order to investigate the mechanism, we analyzed indoleamine 2,3-dioxygenase (IDO) expression in splenic dendritic cell (DC) subsets and tested whether DCs suppress collagen-induced arthritis (CIA) ..
  51. pmc Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection
    Lei Huang
    Cancer Immunology, Inflammation and Tolerance Program, Cancer Center, Georgia Regents University, Augusta, Georgia, United States of America
    PLoS ONE 8:e66546. 2013
    ..Mice lacking intact IDO1 genes (IDO1-KO mice) exhibited significantly lower morbidity after sub-lethal PR8 infection, and genetic or ..
  52. ncbi Neuronal localization of indoleamine 2,3-dioxygenase in mice
    Edward J Roy
    Neuroscience Program and Department of Pathology, College of Medicine, University of Illinois at Urbana Champaign, 506 S Mathews Avenue, Urbana, IL 61801, USA
    Neurosci Lett 387:95-9. 2005
    Indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan to kynurenine. In the immune system, the reduction in tryptophan and increase in kynurenine act to suppress T-cell function...
  53. doi IDO mediates TLR9-driven protection from experimental autoimmune diabetes
    Francesca Fallarino
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 183:6303-12. 2009
    ..In wild-type animals, the disease was accompanied by up-regulation of IDO in pancreatic lymph nodes and would be greatly exacerbated by in vivo administration of an IDO inhibitor...
  54. pmc Studies on tissue and cellular distribution of indoleamine 2,3-dioxygenase 2: the absence of IDO1 upregulates IDO2 expression in the epididymis
    Masakazu Fukunaga
    Human Health Sciences, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Japan
    J Histochem Cytochem 60:854-60. 2012
    Indoleamine 2,3-dioxygenase 1 (IDO1) catabolizes tryptophan to kynurenine at the first step of tryptophan metabolism. Recently, in addition to IDO1, a new isoform called IDO2 was identified...
  55. pmc B7h (ICOS-L) maintains tolerance at the fetomaternal interface
    Leonardo V Riella
    Transplantation Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 182:2204-13. 2013
    ..Locally in the placenta, levels of regulatory markers such as IDO and TGF-β1 were reduced after anti-B7h monoclonal antibody treatment, whereas levels of effector cytokines (eg, ..
  56. pmc IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis
    Antonella De Luca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    PLoS Pathog 9:e1003486. 2013
    ..regulatory T cells, respectively, with a major contribution by the enzyme indoleamine 2,3-dioxygenase 1 (IDO1)...
  57. pmc Immuno-regulatory function of indoleamine 2,3 dioxygenase through modulation of innate immune responses
    Malihe Sadat Poormasjedi-Meibod
    Division of Plastic Surgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e71044. 2013
    ..Immunoprotective effects of indoleamine 2,3-dioxygenase (IDO) on T-cell mediated allorejection has been extensively studied...
  58. ncbi [Echinococcus granulosus recombinant antigen B induced IDO expression in mouse bone marrow-derived dendritic cells in vitro]
    Jiao yu Shan
    Xinjiang Laboratory of Hydatid Fundamental Medicine, The First Affiliated Hospital, China
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 29:111-6. 2011
    To observe the expression of indoleamine 2,3-dioxygenase (IDO) in mouse bone marrow-derived dendritic cells (DCs) after adding Echinococcus granulosus recombinant antigen B (rAgB) in vitro.
  59. pmc A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory protei
    Julia Diegelmann
    Department of Medicine II Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Biol Chem 287:286-98. 2012
    ..signaling, whereas the activation of the anti-inflammatory and anti-bacterial gene indoleamine 2,3-dioxygenase (IDO1) is dependent on STAT1 signal transduction...
  60. doi Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection
    Yuki Murakami
    Human Health Sciences, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Cytokine 59:245-51. 2012
    The regulation of local L-tryptophan concentrations by tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO) induced by various stimuli such as interferon-γ (IFN-γ) is one of the key mechanisms in antimicrobial effect...
  61. pmc Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression
    Hyangin Kim
    MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Invest 122:2940-54. 2012
    ..Here, we report that brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in this comorbidity...
  62. doi Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase
    Kyung Tae Noh
    Department of Microbiology and Immunology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam do 626 870, South Korea
    Biochem Biophys Res Commun 431:348-53. 2013
    ..resveratrol to inhibit the expression and activity of interferon-γ (IFN-γ)-induced indoleamine 2,3-dioxygenase (IDO) in bone marrow-derived dendritic cells (BMDCs)...
  63. doi The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression
    Nikoletta Dobos
    Department of Molecular Neurobiology, University of Groningen, Groningen, The Netherlands
    J Alzheimers Dis 28:905-15. 2012
    Indoleamine 2,3-dioxygenase (IDO), an enzyme which is activated by pro-inflammatory cytokines, has been suggested as a potential link between neuroinflammatory processes in neurodegenerative diseases (like Alzheimer's disease) and ..
  64. pmc IFN-γ and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity
    Ying Lu
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University Medical School, 1365B Clifton Road NE, Atlanta, GA 30322, USA
    Blood 119:1075-85. 2012
    ..Manipulating the content of donor DC precursors in allogeneic HSCT is a novel method to optimize the balance between GVL and GVHD...
  65. pmc Induction of indoleamine 2,3-dioxygenase by uropathogenic bacteria attenuates innate responses to epithelial infection
    Jennifer A Loughman
    Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO 63110 1093, USA
    J Infect Dis 205:1830-9. 2012
    ..UPEC attenuates innate responses to epithelial infection by inducing expression of indoleamine 2,3-dioxygenase (IDO), a host enzyme with previously defined roles in adaptive immune regulation...
  66. pmc M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection
    Antje Blumenthal
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 7:e37314. 2012
    Indoleamine 2,3-dioxygenesae-1 (IDO-1) catalyses the initial, rate-limiting step in tryptophan metabolism, thereby regulating tryptophan availability and the formation of downstream metabolites, including picolinic and quinolinic acid...
  67. doi Endoplasmic reticulum stress response and inflammatory cytokines in type 2 diabetic nephropathy: role of indoleamine 2,3-dioxygenase and programmed death-1
    Babak Baban
    Department of Oral Biology, College of Dental Medicine, Georgia Health Sciences University, Augusta, GA 30912, United States
    Exp Mol Pathol 94:343-51. 2013
    ..of pro-inflammatory cytokines and kidney cell death and b) downregulations of renal indoleamine 2,3-dioxygenase (IDO) and programmed death-1 (PD-1) contribute to exacerbated inflammation and tissue injury...
  68. ncbi Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase
    A Habara-Ohkubo
    Department of Cell Biology, Osaka Bioscience Institute, Suita, Japan
    Gene 105:221-7. 1991
    ..acid (aa), tryptophan, caused by interferon-gamma (IFN-gamma)-mediated induction of indoleamine 2,3-dioxygenase (IDO) in mouse allografted tumor cells, has been suggested as a reason for the allograft rejection...
  69. ncbi Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase
    O Takikawa
    J Biol Chem 261:3648-53. 1986
    ..These findings indicated that indoleamine 2,3-dioxygenase actively oxidized tryptophan in mice and that its induction resulted in an increase in tryptophan degradation...
  70. ncbi Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection
    Ari M Mackler
    Center for the Study of Reproductive Biology and Women s Health, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 170:823-30. 2003
    The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) is expressed in macrophages that have been differentiated in the presence of CSF-1 and is important in the containment of intracellular pathogens...
  71. pmc Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans
    Suzanne Bertera
    Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh School of Medicine, Rangos Research Center, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Exp Diabesity Res 5:201-10. 2004
    ..These genes, indoleamine 2,3-dioxygenase (IDO), manganese superoxide dismutase (MnSOD), and interleukin (IL)-1 receptor antagonist protein (IRAP), were ..
  72. ncbi Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans
    David A Clark
    Biomedical Research Center, Charite, University Medicine of Berlin, Berlin, Germany
    Am J Reprod Immunol 54:203-16. 2005
    Indoleamine 2,3-dioxygenase (IDO) expression in fetal trophoblast and decidual antigen-presenting cells has been proposed to inactivate maternal T cells and thereby prevent rejection of the "fetal allograft" in early pregnancy...
  73. ncbi 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms
    Beom K Choi
    The Immunomodulation Research Center, University of Ulsan, Ulsan 680 749, Republic of Korea
    Cytokine 34:233-42. 2006
    ..T cells that produced IFN-gamma, resulting in accumulation of a high level of indoleamine 2,3-dioxygenase (IDO) in CD11c+ dendritic cells...
  74. ncbi Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference
    Xiufen Zheng
    Department of Surgery, Pathology, Oncology, Microbiology, and Immunology, London Health Science Centre, London, Ontario, Canada
    J Immunol 177:5639-46. 2006
    ..a novel strategy to disrupt tumor-derived immune suppression by silencing a tolerogenic molecule of tumor origin, IDO, using small interfering RNA (siRNA)...
  75. ncbi Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes
    Aito Ueno
    Julia McFarlane Diabetes Research Centre, Department of Biochemistry and Molecular Biology, University of Calgary, Canada
    Diabetes 56:1686-93. 2007
    ....
  76. ncbi Proapoptotic activity of indoleamine 2,3-dioxygenase expressed in renal tubular epithelial cells
    Kanishka Mohib
    Department of Medicine and Microbiology, The University of Western Ontario, London, Ontario, Canada
    Am J Physiol Renal Physiol 293:F801-12. 2007
    ..Indoleamine 2,3-dioxygenase (IDO) converts tryptophan to N-formyl-kynurenine and contributes to immune privilege in tissues by increasing Fas-..
  77. pmc Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality
    Lisa K Jasperson
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN 55455, USA
    Blood 111:3257-65. 2008
    ..The immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by APCs and parenchymal cells and is further inducible by inflammation...
  78. doi Indoleamine 2,3-dioxygenase-dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model
    Yousef A Taher
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    J Allergy Clin Immunol 121:983-91.e2. 2008
    The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in immune suppression and tolerance induction.
  79. doi Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties
    Christopher J D Austin
    Molecular Immunopathology Unit, Bosch Institute, University of Sydney, Sydney, Australia
    Amino Acids 36:99-106. 2009
    The hemoprotein indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the most significant pathway for mammalian tryptophan metabolism...
  80. doi Normal development and function of dendritic cells in mice lacking IDO-1 expression
    Geoffroy de Faudeur
    Laboratoire de Physiologie Animale, Institut de Biologie et Médecine Moléculaire, Universite Libre de Bruxelles, Belgium
    Immunol Lett 118:21-9. 2008
    Dendritic cells (DCs) have been shown to express the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO-1), a protein presently thought to exert dual and possibly contrasting effects on the immune response...
  81. pmc Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation
    Hui Xu
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 105:6690-5. 2008
    Indoleamine 2,3 dioxygenase (IDO) has emerged as an important mediator of immune tolerance via inhibition of Th1 responses...
  82. pmc Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury
    Kanishka Mohib
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Renal Physiol 295:F226-34. 2008
    Indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan to N-formyl kynurenine and has a proapoptotic role in renal tubular epithelial cells (TEC) in response to IFN-gamma and TNF-alpha in vitro...
  83. pmc Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase
    Christoph F A Vogel
    Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616, USA
    Biochem Biophys Res Commun 375:331-5. 2008
    ..Here we show that activation of AhR by TCDD induces DC indoleamine 2,3-dioxygenase 1 (IDO1) and indoleamine 2,3-dioxygenase-like protein (IDO2)...
  84. doi Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria
    Jenny Miu
    Molecular Immunopathology Unit, Bosch Institute and School of Medical Sciences, University of Sydney, NSW, Australia
    Int J Parasitol 39:363-70. 2009
    ..In this study, two different approaches were used to examine the role of indoleamine 2,3-dioxygenase-1 (IDO-1) and its metabolites in the development of murine CM...
  85. doi Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFNgamma
    Anna Maria Gasparri
    Department of Oncology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Mol Cancer Ther 7:3859-66. 2008
    ..We investigated the role of indoleamine 2,3-dioxygenase (IDO), an IFNgamma-inducible enzyme that may down-regulate T cells by affecting local tryptophan catabolism in tumor ..
  86. pmc SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Proc Natl Acad Sci U S A 105:20828-33. 2008
    ..effect of CTLA-4-Ig, including a high functional expression of the tolerogenic enzyme indoleamine 2,3-dioxygenase (IDO). Here we show that forced SOCS3 expression antagonized CTLA-4-Ig activity in a proteasome-dependent fashion...
  87. pmc Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression
    Bridget L Colvin
    Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Hum Immunol 70:313-20. 2009
    We investigated the role of two key immunoregulatory molecules, indoleamine dioxygenase (IDO) and inducible costimulator ligand (ICOSL), in determining the function of bone marrow (BM)-derived plasmacytoid (p)DC, which offer the ..
  88. doi Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock
    In Duk Jung
    Department of Microbiology and Immunology and National Research Laboratory of Dendritic Cell Differentiation and Regulation, Medical Research Institute, Pusan National University, College of Medicine, Busan, South Korea
    J Immunol 182:3146-54. 2009
    ..Indoleamine 2,3-dioxygenase (IDO), which is the rate-limiting enzyme for tryptophan catabolism, may play a critical role in various inflammatory ..
  89. pmc Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
    Masaaki Kanai
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Mol Brain 2:8. 2009
    ..kynurenine pathway of tryptophan metabolism are tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO). Here, we generated mice deficient for tdo (Tdo(-/-))...
  90. doi Interaction between LPS-induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Valpha14 NKT cells
    Hirofumi Ohtaki
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Biochem Biophys Res Commun 389:229-34. 2009
    ..that lipopolysaccharide (LPS) markedly increased nitric oxide (NO) production and indoleamine 2,3-dioxygenase (IDO) activity in mouse peritoneal cells in the presence of activated Valpha14 natural killer T cells...
  91. pmc Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality
    Lisa K Jasperson
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, Minneapolis, MN 55455, USA
    Blood 114:5062-70. 2009
    ..Previously, we demonstrated a crucial role for the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) in GVHD regulation...
  92. pmc Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2,3-dioxygenase
    Mao Lin Yan
    Department of Hepatobiliary Surgery, Fujian Provincial Hospital, Fuzhou 350001, Fujian Province, China
    World J Gastroenterol 16:636-40. 2010
    ..To explore the possibility and mechanism of inhibiting allogeneic T-cell responses by Kupffer cells (KC) pretreated with interferon-gamma (IFN-gamma) in vitro...
  93. pmc Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion
    Alexander J Muller
    Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    Cancer Immunol Immunother 59:1655-63. 2010
    Indoleamine 2,3-dioxygenase (IDO) is generally considered to be immunosuppressive but recent findings suggest this characterization oversimplifies its role in disease pathogenesis...
  94. pmc Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans
    Cornelia Kiank
    Department of Immunology, DFG graduate school GK840, Ernst Moritz Arndt University, Greifswald, Germany
    PLoS ONE 5:e11825. 2010
    ..acoustic and restraint stress) activates the tryptophan (Trp) catabolizing enzyme indoleamine 2,3-dioxygenase 1(IDO1) and thereby alters the immune homeostasis and behavior in mice...
  95. pmc An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
    Joshua D Mezrich
    Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 7375, USA
    J Immunol 185:3190-8. 2010
    ..In this paper, we demonstrate that kynurenine, the first breakdown product in the IDO-dependent tryptophan degradation pathway, activates the AHR...
  96. pmc A crucial role for host APCs in the induction of donor CD4+CD25+ regulatory T cell-mediated suppression of experimental graft-versus-host disease
    Isao Tawara
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Immunol 185:3866-72. 2010
    ..This requirement was independent of their effect on the maintenance of Treg numbers and the production of IL-10 or IDO by the host APCs.
  97. pmc Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO
    Antonella De Luca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Cell Mol Immunol 7:459-70. 2010
    ..adaptor-inducing interferon (TLR3/TRIF)-dependent pathway converging on indoleamine 2,3-dioxygenase (IDO) via non-canonical nuclear factor-κB activation...
  98. pmc Regulation of colonic epithelial cell turnover by IDO contributes to the innate susceptibility of SCID mice to Trichuris muris infection
    L V Bell
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Parasite Immunol 33:244-9. 2011
    ..b>Indo gene expression is upregulated in the gut during chronic infection with the mouse whipworm Trichuris muris...
  99. pmc IDO induces expression of a novel tryptophan transporter in mouse and human tumor cells
    Jonathan D Silk
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington OX3 9DS, United Kingdom
    J Immunol 187:1617-25. 2011
    b>IDO is the rate-limiting enzyme in the kynurenine pathway, catabolizing tryptophan to kynurenine...
  100. ncbi Tryptophan availability selectively limits NO-synthase induction in macrophages
    Alberto Chiarugi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Leukoc Biol 73:172-7. 2003
    ..Our results suggest that a reduced local TRP availability may modify macrophage function and possibly the outcome of immune responses...
  101. ncbi Indoleamine 2,3-dioxygenase (IDO) is involved in promoting the development of anterior chamber-associated immune deviation
    Xuan Chen
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, PR China
    Immunol Lett 107:140-7. 2006
    Indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme in the tryptophan catabolism, has been shown to play an important role in various forms of immune tolerance...

Research Grants7

  1. T CELL IMMUNOREGULATION BY TRYPTOPHAN DEPLETION
    Andrew Mellor; Fiscal Year: 2002
    ..is to examine a novel immunoregulatory mechanism in which cells expressing the enzyme indolamine 2,3 dioxygenase (IDO) regulate T cell responses in vivo...
  2. MACROPHAGE MEDIATED IMMUNOREGULATION VIA TRYPTOPHAN
    David Munn; Fiscal Year: 2002
    ..The mechanism of this inhibition is massive induction of the enzyme indoleamine 2, 3- dioxygenase (IDO), which selectively degrades the essential amino acid tryptophan...
  3. Regulation of T cell immunity by indol 2,3 dioxygenase
    Andrew Mellor; Fiscal Year: 2006
    ..The specific goal of the studies proposed is to evaluate the role of cells expressing indoleamine 2,3 dioxygenase (IDO), which catabolizes tryptophan, in suppressing T cell mediated immunity directed against allogeneic tissues and ..
  4. IDO dependent T cell suppression
    Andrew Mellor; Fiscal Year: 2009
    ..mechanisms that explain how some dendritic cells capable of expressing the enzyme indoleamine 2,3 dioxygenase (IDO-competent DCs) inhibit T cell proliferation, suppress allogeneic T cell responses in vivo, and promote tolerance to ..
  5. T cell regulation by IDO-competent plasmacytoid dendritic cells
    ANDREW LEE MELLOR; Fiscal Year: 2010
    ..pDCs) in humans and mice uniquely competent to express the immunosuppressive enzyme indoleamine 2,3 dioxygenase (IDO)...
  6. Mechanisms of IL-18 Mediated Regulation of GVHD and GVL
    Pavan Reddy; Fiscal Year: 2006
    ..The applicant's sponsor guarantees that 80% of Dr. Reddy's effort will be devoted to his research during this award. ..
  7. THE IMMUNOBIOLOGY OF MURINE ALLOGRAFT ACCEPTANCE
    Charles Cook; Fiscal Year: 2007
    ..In general, these studies will explore the immunobiology of murine allograft acceptance, and its relationship to allograft tolerance. ..