Idh2

Summary

Gene Symbol: Idh2
Description: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Alias: E430004F23, IDPm, Idh-2, isocitrate dehydrogenase [NADP], mitochondrial, ICD-M, IDH, IDP, NADP(+)-specific ICDH, NADP+-specific isocitrate dehydrogenase, oxalosuccinate decarboxylase
Species: mouse

Top Publications

  1. doi Suppression of tumorigenesis in mitochondrial NADP(+)-dependent isocitrate dehydrogenase knock-out mice
    Seontae Kim
    School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Republic of Korea
    Biochim Biophys Acta 1842:135-43. 2014
  2. pmc The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development
    Francois Lemonnier
    The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada
    Proc Natl Acad Sci U S A 113:15084-15089. 2016
  3. doi IDH2 deficiency promotes mitochondrial dysfunction and dopaminergic neurotoxicity: implications for Parkinson's disease
    Hyunjin Kim
    a School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Taegu, Korea
    Free Radic Res 50:853-60. 2016
  4. doi Molecular and Genomic Alterations in Glioblastoma Multiforme
    Inês Crespo
    Centre for Neurosciences and Cell Biology, Faculties of Pharmacy and Medicine, University of Coimbra, Coimbra, Portugal
    Am J Pathol 185:1820-33. 2015
  5. doi IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia
    Yoko Ogawara
    Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 75:2005-16. 2015
  6. doi IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice
    Hyeong Jun Ku
    School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Taegu, Korea
    Free Radic Biol Med 80:84-92. 2015
  7. pmc IDH1 regulates phospholipid metabolism in developing astrocytes
    Elena Bogdanovic
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, D704, Toronto, ON, Canada M4N 3M5 Electronic address
    Neurosci Lett 582:87-92. 2014
  8. doi Mitochondrial NADP(+)-dependent isocitrate dehydrogenase knockdown inhibits tumorigenicity of melanoma cells
    Sung Hwan Kim
    School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Republic of Korea
    Biochem Biophys Res Commun 451:246-51. 2014
  9. doi 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144
    Xiaodong Fu
    Department of Physiology, School of Basic Science, Guangzhou Medical University, Guangzhou, Guangdong Province, China
    Free Radic Biol Med 71:1-15. 2014
  10. pmc Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance
    Lev M Kats
    Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Stem Cell 14:329-41. 2014

Scientific Experts

  • Elena Bogdanovic
  • Jeen Woo Park
  • Jin Hyup Lee
  • Sung Hwan Kim
  • Hyeong Jun Ku
  • Francois Lemonnier
  • Hyunjin Kim
  • Yoko Ogawara
  • Inês Crespo
  • Kwon Moo Park
  • Lev M Kats
  • Xiaodong Fu
  • Seontae Kim
  • Chong Chen
  • Wei Yu
  • Qian Lu
  • Ai Hyang Shin
  • Hanvit Cha
  • Sophie Broutin
  • Sang Ryong Kim
  • Laurence de Leval
  • Rohini Narayanaswamy
  • Bryan E Snow
  • Erica R Tobin
  • Katherine Yen
  • Romain Pelletier
  • Angelo Paci
  • Wanda Y Li
  • Aurélie Dupuy
  • Andrew Wakeham
  • Satoshi Inoue
  • Tak W Mak
  • Philippe Gaulard
  • Rob A Cairns
  • Nadine Martin
  • Anaïs Pujals
  • Shengfang Jin
  • Virginie Fataccioli
  • Corinne Haioun
  • Yuki Kagiyama
  • Kazushi Araki
  • Catarina de Oliveira
  • Maria Dolores Tabernero
  • Takuo Katsumoto
  • Alvaro Otero
  • Alberto Orfao
  • Maria Celeste Lopes
  • Maria Del Carmen Patino
  • Patricia Domingues
  • Takahiko Seki
  • María Gonzalez-Tablas
  • Youngkeun Ahn
  • Yutaka Shima
  • Hironori Matsunaga
  • Yukiko Aikawa
  • Issay Kitabayashi
  • Tomoyoshi Soga
  • Ana Louisa Vital
  • Min Xia
  • Parul Bhargava
  • Kerri Burgess
  • Ho Won Lee
  • Xiuwei Huang
  • Young Hyun Yoo
  • Yong Hyun Jeon
  • Taeg Kyu Kwon
  • Markus Reschke
  • Pier Paolo Pandolfi
  • Kimberly Straley
  • Olga Pozdnyakova
  • Jaetae Lee
  • Shinsan M Su
  • Weiyu Chen
  • Sung Youl Kim
  • Riccardo Taulli
  • Katharine Yen
  • Ping Li
  • Rahul Karnik
  • Alexander Meissner
  • Jiangwen Zhang
  • Donald Small
  • Justin R Cross
  • John P Morris
  • Scott W Lowe
  • Chao Lu
  • Aditya S Shroff
  • Craig Thompson
  • Patrick S Ward
  • Yu Liu
  • James E Bradner

Detail Information

Publications20

  1. doi Suppression of tumorigenesis in mitochondrial NADP(+)-dependent isocitrate dehydrogenase knock-out mice
    Seontae Kim
    School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Republic of Korea
    Biochim Biophys Acta 1842:135-43. 2014
    ..oxidative damage is one of the primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2) that supplies NADPH for antioxidant systems...
  2. pmc The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development
    Francois Lemonnier
    The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada
    Proc Natl Acad Sci U S A 113:15084-15089. 2016
    Oncogenic isocitrate dehydrogenase (IDH)1 and IDH2 mutations at three hotspot arginine residues cause an enzymatic gain of function that leads to the production and accumulation of the metabolite 2-hydroxyglutarate (2HG), which ..
  3. doi IDH2 deficiency promotes mitochondrial dysfunction and dopaminergic neurotoxicity: implications for Parkinson's disease
    Hyunjin Kim
    a School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Taegu, Korea
    Free Radic Res 50:853-60. 2016
    ..One of these factors, mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2), has been implicated in the regulation of mitochondrial redox balance and reduction of oxidative stress-induced ..
  4. doi Molecular and Genomic Alterations in Glioblastoma Multiforme
    Inês Crespo
    Centre for Neurosciences and Cell Biology, Faculties of Pharmacy and Medicine, University of Coimbra, Coimbra, Portugal
    Am J Pathol 185:1820-33. 2015
    ..Herein, we review the most relevant genetic alterations of primary versus secondary GBM, the specific signaling pathways involved, and the overall genomic profile of this genetically heterogeneous group of malignant tumors. ..
  5. doi IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia
    Yoko Ogawara
    Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 75:2005-16. 2015
    IDH1 and IDH2 mutations occur frequently in acute myeloid leukemia (AML) and other cancers...
  6. doi IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice
    Hyeong Jun Ku
    School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Taegu, Korea
    Free Radic Biol Med 80:84-92. 2015
    ..we have demonstrated that one of the primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2) is to control the mitochondrial redox balance, and thereby mediate the cellular defense against oxidative damage, ..
  7. pmc IDH1 regulates phospholipid metabolism in developing astrocytes
    Elena Bogdanovic
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, D704, Toronto, ON, Canada M4N 3M5 Electronic address
    Neurosci Lett 582:87-92. 2014
    ..In conclusion, our results reveal a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity. ..
  8. doi Mitochondrial NADP(+)-dependent isocitrate dehydrogenase knockdown inhibits tumorigenicity of melanoma cells
    Sung Hwan Kim
    School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Republic of Korea
    Biochem Biophys Res Commun 451:246-51. 2014
    ..Mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2), an NADPH-generating enzyme, is one of the major antioxidant and redox regulators in mitochondria...
  9. doi 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144
    Xiaodong Fu
    Department of Physiology, School of Basic Science, Guangzhou Medical University, Guangzhou, Guangdong Province, China
    Free Radic Biol Med 71:1-15. 2014
    ..this study was to determine the effects and mechanisms of 7-ketocholesterol (7-KC) on isocitrate dehydrogenase 2 (IDH2) and its impact on endothelial function in both human aortic endothelial cells (HAECs) and C57BL/6J mice...
  10. pmc Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance
    Lev M Kats
    Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Stem Cell 14:329-41. 2014
    Mutations in the metabolic enzymes isocitrate dehydrogenase-1 (IDH1) and IDH2 that produce the oncometabolite D-2-hydroxyglutarate (2-HG) occur frequently in human acute myeloid leukemia (AML)...
  11. pmc Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
    Chong Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genes Dev 27:1974-85. 2013
    Somatic mutations in the isocitrate dehydrogenase (IDH) genes IDH1 and IDH2 occur frequently in acute myeloid leukemia (AML) and other cancers...
  12. pmc SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
    Wei Yu
    Department of Biomolecular Chemistry and the Wisconsin Institute for Discovery, University of Wisconsin Madison, Madison, Wisconsin 53715, USA
    J Biol Chem 287:14078-86. 2012
    ..The mitochondrial matrix protein isocitrate dehydrogenase 2 (IDH2) is a major source of NADPH...
  13. ncbi Genetic characterization of important mouse strains used in cancer research
    H H Krog
    Hereditas 87:201-4. 1977
  14. pmc Dual compartmental localization and function of mammalian NADP+-specific isocitrate dehydrogenase in yeast
    Qian Lu
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Arch Biochem Biophys 472:17-25. 2008
    Isozymes of NADP+-specific isocitrate dehydrogenase (IDP) provide NADPH in cytosolic, mitochondrial, and peroxisomal compartments of eukaryotic cells...
  15. ncbi Regulation of high glucose-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase
    Ai Hyang Shin
    Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Republic of Korea
    Biochem Biophys Res Commun 325:32-8. 2004
    ..oxidative damage is one of the primary functions of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) to supply NADPH for antioxidant systems...
  16. ncbi Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase
    S H Jo
    Departments of Genetic Engineering and Biochemistry, Kyungpook National University, Taegu 702 701, Korea
    J Biol Chem 276:16168-76. 2001
    ..We investigated the role of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) in controlling the mitochondrial redox balance and subsequent cellular defense against oxidative damage...
  17. ncbi Molecular cloning of the cDNA of mouse mitochondrial NADP-dependent isocitrate dehydrogenase and the expression of the gene during lymphocyte activation
    L Yang
    Department of Medicine, Notre Dame Hospital Research Center and Nephrology Service, Montreal, Quebec, Canada
    J Cell Biochem 60:400-10. 1996
    ..report documents the molecular cloning of the mouse mitochondrial NADP-dependent isocitrate dehydrogenase (mNADP-IDH) cDNA...
  18. ncbi Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7
    R L Stallings
    Somatic Cell Genet 7:683-98. 1981
    ..The assignments provide markers for the study of the genetic consequences of chromosomal rearrangements in Chinese hamster cell lines and support the concept of conservation of mammalian autosomal linkage groups...
  19. ncbi Comparative gene mapping in man and mouse: assignment of the genes for lactate dehydrogenase-A, peptidase-D, and isocitrate dehydrogenase-2 to mouse chromosome 7
    P A Lalley
    Cytogenet Cell Genet 22:577-80. 1978
  20. ncbi Conservation of autosomal gene synteny groups in mouse and man
    P A Lalley
    Nature 274:160-3. 1978