Icosl

Summary

Gene Symbol: Icosl
Description: icos ligand
Alias: AU044799, B7-H2, B7RP-1, B7h, BG071784, GI50, GL50, GL50-B, ICOS-L, Icoslg, LICOS, Ly115l, mKIAA0653, ICOS ligand, B7 homolog 2, B7-like protein Gl50, B7-related protein 1
Species: mouse

Top Publications

  1. ncbi Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection
    E Ozkaynak
    Millennium Pharmaceuticals, Inc, 75 Sidney Street, Cambridge, MA 02139, USA
    Nat Immunol 2:591-6. 2001
  2. ncbi T-cell co-stimulation through B7RP-1 and ICOS
    S K Yoshinaga
    Amgen Inc, Thousand Oaks, California 91320, USA
    Nature 402:827-32. 1999
  3. ncbi ICOS controls the pool size of effector-memory and regulatory T cells
    Yvonne Burmeister
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    J Immunol 180:774-82. 2008
  4. pmc B7h is required for T cell activation, differentiation, and effector function
    Roza I Nurieva
    Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
    Proc Natl Acad Sci U S A 100:14163-8. 2003
  5. ncbi B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells
    Yi Ling Hu
    Department of Inflammation, Amgen, Inc, Thousand Oaks, CA 91320, USA
    J Immunol 182:1421-8. 2009
  6. pmc Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells
    Bryan S Clay
    Committee on Immunology, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e7525. 2009
  7. ncbi Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses
    Tak W Mak
    Advanced Medical Discovery Institute, and Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada
    Nat Immunol 4:765-72. 2003
  8. ncbi ICOS is critical for CD40-mediated antibody class switching
    A J McAdam
    Departments of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 409:102-5. 2001
  9. ncbi Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor
    V Ling
    Department of Immunology, Genetics Institute, Cambridge, MA 02081, USA
    J Immunol 164:1653-7. 2000
  10. ncbi B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha
    M M Swallow
    Molecular and Cell Biology Department, University of California, Berkeley 94720, USA
    Immunity 11:423-32. 1999

Patents

  1. Gl50 molecules and uses therefor

Scientific Experts

  • Lino L Teichmann
  • Kevin Larimore
  • S K Yoshinaga
  • V Ling
  • A I Sperling
  • Tak Wah Mak
  • Hisaya Akiba
  • Ying Waeckerle-Men
  • Omid Akbari
  • I E A Flesch
  • Tamson V Moore
  • Kong Peng Lam
  • Hideo Yagita
  • J F Du
  • Andreas Hutloff
  • Kamran Kadkhoda
  • Bryan S Clay
  • Chen Dong
  • Siew Cheng Wong
  • Timo Lischke
  • Rebecca A Shilling
  • Judy L Cannon
  • Yvonne Burmeister
  • Shuhe Wang
  • Xi Yang
  • Yijun Fan
  • Xiaohan Hu
  • Sonia Bakkour
  • Roza Nurieva
  • Bo Wang
  • Dan Liu
  • Hadi Maazi
  • Andrea J White
  • Jason S Weinstein
  • Joanna Marczynska
  • Chiara Dianzani
  • B Wang
  • Bin Wang
  • Xijun Ou
  • F Y Zuo
  • X Bai
  • B Yu
  • G Chen
  • X Q Ji
  • Xiaomeng Nie
  • Graham Anderson
  • Sigrid E Sandner
  • Mohamed H Sayegh
  • Hongbo Hu
  • Shintaro Maeda
  • Youn Soo Choi
  • Tihui Fu
  • Sheng Yao
  • Marion Pepper
  • Lieping Chen
  • Hans Werner Mages
  • Tomohiro Fukaya
  • Richard A Kroczek
  • Nicolas Prevot
  • Michelle A Linterman
  • Yi Ling Hu
  • Gordon J Freeman
  • Arlene H Sharpe
  • Craig L Maynard
  • Ryuichi Sugamata
  • Bridget L Colvin
  • Hongyu Qiu
  • Jie Yang
  • Yeonseok Chung
  • Masashi Watanabe
  • Anna Tafuri
  • William C Sha
  • Ping Zhang
  • Yoshihiko Usui
  • Eric C Logue
  • Xiaobing Han
  • Miyuki Azuma
  • Dragana Odobasic
  • J J Wallin
  • G J Freeman
  • Anthony J Coyle
  • Hisanori Kashizuka
  • Beata U Gajewska
  • Alan D Salama
  • Masayuki Sho
  • Ko Okumura
  • Yumin Hu
  • Karen M Smith
  • Yu Shen
  • R Iiyama

Detail Information

Publications74

  1. ncbi Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection
    E Ozkaynak
    Millennium Pharmaceuticals, Inc, 75 Sidney Street, Cambridge, MA 02139, USA
    Nat Immunol 2:591-6. 2001
    ..These data demonstrate a key role for the ICOS-B7RP-1 pathway in acute and chronic rejection and highlight the benefits of targeting this pathway in combination with the use of conventional immunosuppressive agent...
  2. ncbi T-cell co-stimulation through B7RP-1 and ICOS
    S K Yoshinaga
    Amgen Inc, Thousand Oaks, California 91320, USA
    Nature 402:827-32. 1999
    ..Therefore, B7RP-1 exhibits co-stimulatory activities in vitro and in vivo. ICOS and B7RP-1 define a new and distinct receptor-ligand pair that is structurally related to CD28-B7 and is involved in the adaptive immune response...
  3. ncbi ICOS controls the pool size of effector-memory and regulatory T cells
    Yvonne Burmeister
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    J Immunol 180:774-82. 2008
    ..This concept may reconcile a number of past in vivo studies with seemingly contradictory results on ICOS function...
  4. pmc B7h is required for T cell activation, differentiation, and effector function
    Roza I Nurieva
    Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
    Proc Natl Acad Sci U S A 100:14163-8. 2003
    ..A ligand for ICOS, B7h, is expressed on B cells and other types of antigen-presenting cells (APC)...
  5. ncbi B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells
    Yi Ling Hu
    Department of Inflammation, Amgen, Inc, Thousand Oaks, CA 91320, USA
    J Immunol 182:1421-8. 2009
    ..These findings further support the role of ICOS in autoimmunity and suggest that the expansion of the T(FH) cell pool is an important mechanism by which ICOS regulates Ab production...
  6. pmc Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells
    Bryan S Clay
    Committee on Immunology, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e7525. 2009
    ..However, it is unknown if increased ICOS expression contributes to disease progression or is a result of disease pathology...
  7. ncbi Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses
    Tak W Mak
    Advanced Medical Discovery Institute, and Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada
    Nat Immunol 4:765-72. 2003
    Costimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and temporal dynamics underlying its in vivo effects are poorly defined...
  8. ncbi ICOS is critical for CD40-mediated antibody class switching
    A J McAdam
    Departments of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 409:102-5. 2001
    ..Class switching was restored in ICOS-/- mice by CD40 stimulation, showing that ICOS promotes T-cell/B-cell collaboration through the CD40/CD40L pathway...
  9. ncbi Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor
    V Ling
    Department of Immunology, Genetics Institute, Cambridge, MA 02081, USA
    J Immunol 164:1653-7. 2000
    ..Subsequent phenotyping demonstrated high levels of ICOS ligand staining on splenic CD19+ B cells and low levels on CD3+ T cells...
  10. ncbi B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha
    M M Swallow
    Molecular and Cell Biology Department, University of California, Berkeley 94720, USA
    Immunity 11:423-32. 1999
    In a screen to identify genes induced by NF-kappaB/Rel transcription factors, we cloned a novel gene, b7h, that is a close homolog of B7 costimulatory ligands expressed on antigen-presenting cells...
  11. pmc Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    G J Freeman
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1027-34. 2000
    ..PD-L1 expression on nonlymphoid tissues and its potential interaction with PD-1 may subsequently determine the extent of immune responses at sites of inflammation...
  12. ncbi ICOS is essential for effective T-helper-cell responses
    A Tafuri
    Amgen Institute, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada
    Nature 409:105-9. 2001
    ..ICOS-deficient T cells primed in in vivo and restimulated in vitro with specific antigen produce only low levels of interleukin-4, but remain fully competent to produce interferon-gamma...
  13. ncbi Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses
    Masashi Watanabe
    Division of Cell Signaling Regulation, Genome and Drug Research Center, Research Institute for Biological Sciences, Tokyo University of Sciences, Noda, Chiba 278 0022, Japan
    J Immunol 180:5222-34. 2008
    Although it is well-known that the ICOS-ICOS ligand (ICOSL) costimulatory pathway is important for many immune responses, recent accumulated evidence suggests that dysregulation of this pathway may lead to and/or exaggerate autoimmune ..
  14. ncbi ICOS-induced B7h shedding on B cells is inhibited by TLR7/8 and TLR9
    Eric C Logue
    Immunology Division, Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 177:2356-64. 2006
    We report in this study that B7h, the ligand for the ICOS costimulatory receptor, is rapidly shed from mouse B cells following either ICOS binding or BCR engagement...
  15. pmc B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen
    Jason S Weinstein
    Section of Rheumatology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520
    J Immunol 192:3166-79. 2014
    B cells are required for follicular Th (Tfh) cell development, as is the ICOS ligand (ICOS-L); however, the separable contributions of Ag and ICOS-L delivery by cognate B cells to Tfh cell development and function are unknown...
  16. pmc An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells
    Andrea J White
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 192:2659-66. 2014
    ..Moreover, the identification of a novel requirement for iNKT cells in thymus medulla development further highlights the role of both innate and adaptive immune cells in thymus medulla formation. ..
  17. doi Inhibition of T-cell expansion caused by inducible costimulator/B7h costimulation blockade in direct allorecognition pathway
    J F Du
    Department of General Surgery, General Hospital of Beijing Military Command, Beijing, China
    Transplant Proc 43:3960-3. 2011
    Inducible costimulator (ICOS)/B7h costimulation plays a crucial role in acute and chronic allograft rejection...
  18. pmc Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62L
    Tamson V Moore
    Committee on Immunology and Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 45:843-50. 2011
    ....
  19. pmc Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus
    Lino L Teichmann
    Department of Medicine III, University of Bonn School of Medicine, 53127 Bonn, Germany Electronic address
    Immunity 42:552-65. 2015
    ..Here we show that selective ablation of ICOS ligand (ICOSL) in CD11c(+) cells, but not in B cells, dramatically ameliorates kidney and lung inflammation in lupus-..
  20. doi B7h triggering inhibits the migration of tumor cell lines
    Chiara Dianzani
    Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy
    J Immunol 192:4921-31. 2014
    Vascular endothelial cells (ECs) and several cancer cells express B7h, which is the ligand of the ICOS T cell costimulatory molecule...
  21. pmc ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity
    Hadi Maazi
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles, California 90033, USA
    Immunity 42:538-51. 2015
    ..Thus, ICOS:ICOS-ligand signaling pathway is critically involved in ILC2 function and homeostasis...
  22. doi The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses
    Joanna Marczynska
    Department of Immunology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, 30 387 Krakow, Poland
    J Immunol 193:2753-63. 2014
    ..Moreover, we demonstrate that the costimulatory ligand ICOS ligand (ICOSL) is selectively downregulated on the surface of B cells in an ADAM17-specific manner, although it is not ..
  23. doi T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction
    Dan Liu
    Tsinghua Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University, 100084 Beijing, China
    Nature 517:214-8. 2015
    ..that, beyond the role in promoting TFH development, ICOSL (inducible T-cell co-stimulator ligand, also known as ICOSLG) is important for individual B cells to competitively participate in the GC reaction and to develop into BMPCs...
  24. doi Development of a novel monoclonal antibody to human inducible co-stimulator ligand (ICOSL): Biological characteristics and application for enzyme-linked immunosorbent assay
    Xiaohan Hu
    Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China Department of Immunology, Medical College of Soochow University, Suzhou 215006, China
    Int Immunopharmacol 36:151-7. 2016
    b>ICOSL (B7-H2, CD275), a co-stimulatory molecule of the B7 superfamily, functions as a positive signal in immune response...
  25. pmc Th17 down-regulation is involved in reduced progression of schistosomiasis fibrosis in ICOSL KO mice
    Bo Wang
    Department of Parasitology, Medical College of Soochow University, Suzhou, Jiangsu Province, The Peoples Republic of China
    PLoS Negl Trop Dis 9:e0003434. 2015
    ..b>ICOSL plays an important role in controlling specific aspects of T cell activation, differentiation, and function...
  26. doi Expression of ICOSLG on mouse hematologic neoplasm cell lines and their influence on cytotoxicity in allogeneic mixed lymphocyte reactions
    Bin Wang
    Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai, China
    Leuk Lymphoma 53:674-80. 2012
    In this study, we sought to determine whether the expression of inducible co-stimulator ligand (ICOSLG) on mouse hematologic neoplasm cells influences cytotoxicity...
  27. ncbi Inducible costimulatory molecule-B7-related protein 1 interactions are important for the clonal expansion and B cell helper functions of naive, Th1, and Th2 T cells
    Karen M Smith
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, UK
    J Immunol 170:2310-5. 2003
    ..Furthermore, while ICOS-B7RP-1 interactions have no effect on the migration of T cells into B cell follicles, it is essential for their ability to support B cell responses...
  28. doi Apoptosis of peripheral T cells in rodent cardiac allograft recipients induced by donor-specific transfusion with impaired inducible costimulator/B7 homologous protein allorecognition
    J F Du
    Department of General Surgery, General Hospital of Beijing Military Command, Beijing, PR China
    Transplant Proc 45:564-8. 2013
    ..of the CD8(+) T cells (Tc) subpopulation in rodent cardiac allograft recipients, which were treated by donor specific transfusion combined with blockade of Inducible costimulator (ICOS)/B7 homologous protein (B7h) costimulation.
  29. doi Effects of ICOSLG expressed in mouse hematological neoplasm cell lines in the GVL reaction
    B Wang
    Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China
    Bone Marrow Transplant 48:124-8. 2013
    As a member of the B7 family, inducible co-stimulator ligand (ICOSLG) expressed on tumor cell has been reported to have an important role in tumor immunity...
  30. pmc B7h-expressing dendritic cells and plasma B cells mediate distinct outcomes of ICOS costimulation in T cell-dependent antibody responses
    Kevin Larimore
    Immunology Division, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    BMC Immunol 13:29. 2012
    The ICOS-B7h costimulatory receptor-ligand pair is required for germinal center formation, the production of isotype-switched antibodies, and antibody affinity maturation in response to T cell-dependent antigens...
  31. doi Comprehensive analysis of CD4+ T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS
    Timo Lischke
    Molecular Immunology, Robert Koch Institute, 13353 Berlin, Germany
    J Immunol 189:234-44. 2012
    ..Given its exceptionally selective induction on CD4(+) T cells under inflammatory, but not tolerogenic, conditions, ICOS emerges as a pivotal effector molecule in the early decision between tolerance and immunity to exogenous Ag...
  32. ncbi B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance
    Beata U Gajewska
    Department of Pathology and Molecular Medicine, and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Immunol 174:3000-5. 2005
    ..In summary, our results demonstrate that in a model of mucosal allergic sensitization, the ICOS-B7RP-1 pathway is redundant for the generation of Th2 responses but essential for the induction of inhalation tolerance...
  33. doi Lipopolysaccharide mediated mast cells induce IL-10 producing regulatory T cells through the ICOSL/ICOS axis
    Xiaomeng Nie
    Department of Respiratory Diseases, Changhai Hospital, The Second Military Medical University, Shanghai, PR China
    Clin Immunol 142:269-79. 2012
    ..Induction of IL-10 producing regulatory T cells mainly relied on the inducible costimulator ligand (ICOSL)/ICOS axis...
  34. pmc Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival
    Xijun Ou
    Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore
    Proc Natl Acad Sci U S A 109:15401-6. 2012
    ..Thus, our data reveal dual roles for TACI in B-cell terminal differentiation. On one hand, TACI modulates ICOS ligand expression and thereby limits the size of T(fh) and GC B-cell compartments and prevents autoimmunity...
  35. pmc B7-h2 is a costimulatory ligand for CD28 in human
    Sheng Yao
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 34:729-40. 2011
    ..Our findings warrant re-evaluation of CD28 and CTLA-4's functions previously attributed exclusively to B7-1 and B7-2 and have important implications in therapeutic interventions against human diseases...
  36. doi ICOS ligand expression is essential for allergic airway hyperresponsiveness
    Kamran Kadkhoda
    Immune Regulation of Allergy Research Group, Laboratory for Infection and Immunity, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
    Int Immunol 23:239-49. 2011
    Inducible co-stimulator ligand (ICOSL) is a rather newly defined co-stimulatory molecule, which, through interaction with ICOS expressed on T cells, plays an important role in T-cell activation, differentiation and function...
  37. pmc ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    Youn Soo Choi
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 34:932-46. 2011
    ..Tfh cells were subsequently lost in the absence of B cells, demonstrating a B cell requirement for maintenance of Bcl6 and Tfh cell commitment via sequential ICOS signals...
  38. doi The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy
    Tihui Fu
    Departments of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 71:5445-54. 2011
    ..ICOS and its ligand (ICOSL) have been shown to play diverse roles in T-cell responses such as mediating autoimmunity as well as enhancing the ..
  39. pmc Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development
    Hongbo Hu
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 108:12827-32. 2011
    ..NIK and its upstream BAFF receptor regulate B-cell expression of inducible costimulator ligand (ICOSL), a molecule required for Tfh cell generation...
  40. pmc Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production
    Shintaro Maeda
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Am J Pathol 179:2360-9. 2011
    ..Inducible costimulator (ICOS), expressed on activated T cells, and its ligand, ICOS ligand (ICOSL), expressed on antigen-presenting cells, have been considered a single receptor-ligand pair...
  41. pmc Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
    Marion Pepper
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Immunity 35:583-95. 2011
    ..Thus, Th1 effector memory and follicular helper-like central memory cells are produced from early effector cell populations that diverge in response to signals from the IL-2 receptor, Bcl6, and B cells...
  42. ncbi Inducible costimulator-ligand (ICOS-L)
    I E A Flesch
    Child Health Research Institute, North Adelaide, Australia
    J Biol Regul Homeost Agents 16:217-9. 2002
  43. ncbi Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation
    Hideyuki Iwai
    Department of Molecular Immunology, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Immunol 169:4332-9. 2002
    B7 homologous protein (B7h)/B7-related protein 1 (B7RP-1) is a new member of the B7 family of costimulatory molecules that specifically interacts with inducible costimulator (ICOS) expressed on activated T cells...
  44. ncbi Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, USA
    Nat Med 8:1024-32. 2002
    ..These studies demonstrate that T(R) cells and the ICOS-ICOS-ligand signaling pathway are critically involved in respiratory tolerance and in downregulating pulmonary inflammation in asthma...
  45. ncbi ICOS costimulation: It's not just for TH2 cells anymore
    A I Sperling
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    Nat Immunol 2:573-4. 2001
    ..A current paradigm has ICOS participating in TH2 costimulation. New data indicates ICOS regulates not only TH2 cells, but also TH1s...
  46. ncbi Enhancement of CD8+ T cell responses by ICOS/B7h costimulation
    J J Wallin
    Immunology Division, Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 167:132-9. 2001
    Although the recently identified ICOS/B7h costimulatory counterreceptors are critical regulators of CD4(+) T cell responses, their ability to regulate CD8(+) responses is unclear...
  47. ncbi Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse GL50-B and human GL50 molecules
    V Ling
    Department of Immunology, Genetics Institute, Wyeth Research, Cambridge, MA 02081
    J Immunol 166:7300-8. 2001
    ..that freshly isolated B cells, T cells, macrophages, and dendritic cells express both splice variant forms of ICOS ligand. Comparative analyses with the human ICOS ligand splice variants hGL50 and B7-H2 indicate that differential ..
  48. pmc B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    S Y Tseng
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Exp Med 193:839-46. 2001
    ..These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses...
  49. ncbi Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family?
    M A Aurrand-Lions
    Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
    Curr Top Microbiol Immunol 251:91-8. 2000
  50. ncbi Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand
    H W Mages
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Eur J Immunol 30:1040-7. 2000
    ..The muICOS gene was mapped to a region of chromosome 1 also harboring the CD28 and CTLA-4 genes. Using recombinant chimeric muICOS-Ig we determined that B7h, a recently cloned B7-like molecule, is a ligand for muICOS.
  51. pmc The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity
    Hiroshi Harada
    Department of Medicine, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 112:234-43. 2003
    ..These data define the complex functions of the ICOS-B7h pathway in regulating alloimmune responses in vivo.
  52. ncbi Inducible co-stimulatory molecule ligand is protective during the induction and effector phases of crescentic glomerulonephritis
    Dragana Odobasic
    Department of Medicine, Monash University, Monash Medical Centre, Level 5 Block E, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Am Soc Nephrol 17:1044-53. 2006
    The inducible co-stimulatory molecule (ICOS)/ICOS ligand (ICOSL) co-stimulatory pathway is critical in T cell activation, differentiation, and effector function...
  53. ncbi Chlamydia infection induces ICOS ligand-expressing and IL-10-producing dendritic cells that can inhibit airway inflammation and mucus overproduction elicited by allergen challenge in BALB/c mice
    Xiaobing Han
    Immune Regulation of Allergy Research Group, Departments of Medical Microbiology and Immunology, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada
    J Immunol 176:5232-9. 2006
    ..The study revealed that iIDCs exhibited higher surface expression of CD8alpha and the ICOS ligand (ICOS-L), as well as higher IL-10 and IL-12 production than iNDCs...
  54. pmc T-cell tolerance or function is determined by combinatorial costimulatory signals
    Roza Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 25:2623-33. 2006
    ..This work demonstrates that T-cell function or tolerance is controlled by costimulatory signals...
  55. ncbi Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection
    Hisanori Kashizuka
    Department of Surgery, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Transplantation 79:1045-50. 2005
    ..Recent studies indicated that the ICOS-B7h pathway plays an important role in alloimmune responses...
  56. ncbi The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis
    Yoshihiko Usui
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Immunol 36:3071-81. 2006
    ..We also indicated that ICOS-mediated costimulation plays differential roles in EAU and experimental autoimmune encephalomyelitis, which is also a Th1 disease induced in the same manner as EAU...
  57. pmc The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells
    Ping Zhang
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202, USA
    J Immunol 178:474-9. 2007
    ..Our results show that anti-costimulatory molecule treatment can have diverse actions on autoreactive T cell subsets, the net effect being determined by the subset of immune cells affected and the type and dose of treatment used...
  58. ncbi Limited costimulatory molecule expression on renal tubular epithelial cells impairs T cell activation
    Ying Waeckerle-Men
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich Irchel, Zurich, Switzerland
    Kidney Blood Press Res 30:421-9. 2007
    ..The aim of this study was to compare the costimulatory molecule expression pattern and the T cell activation capacity between renal TEC and professional APC, e.g. bone marrow-derived dendritic cells (BM-DC)...
  59. ncbi A critical role of costimulation during intrathymic development of invariant NK T cells
    Yeonseok Chung
    Department of Immunology, M D Anderson Cancer Center, 7455 Fannin, Houston, TX 77030, USA
    J Immunol 180:2276-83. 2008
    ..Here we report that mice deficient in CD80/CD86 and/or B7h exhibit severe defects in thymic iNKT cell maturation, associated with largely reduced iNKT cell number in the ..
  60. doi Mapping of the ICOS binding surface of murine B7h using an unbiased, cellular library of B7h mutants created by cyclical packaging rescue
    Sonia Bakkour
    Cancer Research Laboratory, 441 LSA, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200 United States
    J Immunol Methods 332:151-61. 2008
    ..approach, we generated a 3T3 cellular library retrovirally expressing 2 x 10(5) mutants of the murine costimulatory B7h gene...
  61. ncbi Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection
    Sigrid E Sandner
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 5:31-9. 2005
    ..class II mismatched model of CD4(+) T-cell-mediated rejection, we found that treatment of mice with DST and ICOS-B7h blockade induced long-term skin allograft survival and donor-specific transplantation tolerance...
  62. pmc ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival
    Omid Akbari
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA, 02115, USA
    J Immunol 180:5448-56. 2008
    ..Furthermore, the number of CD4(+) iNKT cells was significantly lower in spleens and livers of ICOS(-/-) and ICOSL(-/-) mice, and the remaining iNKT cells in ICOS(-/-) mice were dysfunctional and failed to reconstitute AHR when ..
  63. ncbi Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2
    Siew Cheng Wong
    Institute of Molecular and Cell Biology, Singapore, Republic of Singapore
    Blood 102:1381-8. 2003
    ..Hence, B7-H2 on B cells is important for recruiting T-cell help via its interaction with ICOS and plays a critical role in costimulating humoral immune responses...
  64. pmc Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells
    Craig L Maynard
    Department of Pathology, University of Alabama at Birmingham, AL 35294, USA
    J Exp Med 206:343-57. 2009
    ....
  65. pmc Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression
    Bridget L Colvin
    Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Hum Immunol 70:313-20. 2009
    ..the role of two key immunoregulatory molecules, indoleamine dioxygenase (IDO) and inducible costimulator ligand (ICOSL), in determining the function of bone marrow (BM)-derived plasmacytoid (p)DC, which offer the potential for ..
  66. doi Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS
    Michelle A Linterman
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Immunity 30:228-41. 2009
    ..b>ICOS ligand, unlike the pathogen-inducible CD28 ligands, is widely and constitutively expressed in the immune system...
  67. doi Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity
    Siew Cheng Wong
    Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore
    Cell Immunol 256:64-71. 2009
    ..Taken together, our data reveal a functional hierarchy of the CD28/B7 and ICOS/B7-H2 pathways and delineated their relative contributions to the elicitation of a DTH response...
  68. doi Teleost B7 expressed on monocytes regulates T cell responses
    Ryuichi Sugamata
    Fisheries Laboratory, Graduate School of Agricultural and Life Sciences, University of Tokyo, Hamamatsu, Japan
    J Immunol 182:6799-806. 2009
    ..These observations indicate that fugu B7s regulate T cell responses via receptors upon T cells. We suggest that fish B7(+) monocytes are APCs and that a costimulatory system has already developed in fish via the evolutionary process...
  69. ncbi The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches
    R Iiyama
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Immunol Lett 88:63-70. 2003
    ..Moreover, production of IgA and IgG, but not IgM was significantly reduced in PPs in ICOS(-/-) mice. These data suggest that ICOS/B7RP-1 interactions may not affect the organogenesis, but involve in the functional development of PPs...
  70. doi Th1 cytokine responses fail to effectively control Chlamydia lung infection in ICOS ligand knockout mice
    Kamran Kadkhoda
    Laboratory for Infection and Immunity, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 184:3780-8. 2010
    b>ICOS ligand (ICOSL) plays an important role in controlling specific aspects of T cell activation, differentiation, and function. Th1-type immune responses have been shown to be critical in host defense against chlamydial infections...
  71. doi Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system
    Nicolas Prevot
    INSERM U986, Hôpital Cochin St Vincent de Paul, Paris, France
    Eur J Immunol 40:2267-76. 2010
    ..In this study, we provide evidence that the Icos and Icosl genes contribute to the diabetes process...
  72. pmc Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance
    Tomohiro Fukaya
    Laboratory for Dendritic Cell Immunobiology, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Kanagawa, Japan
    Blood 116:2266-76. 2010
    ..In conclusion, our findings suggest that B7-H1 and B7-DC expressed on MLN DCs are essential for establishing oral tolerance through the de novo generation of antigen-specific CD4(+)Foxp3(+) iT(regs)...
  73. pmc Protective effector memory CD4 T cells depend on ICOS for survival
    Tamson V Moore
    Committee on Immunology and Section of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e16529. 2011
    ..Herein, we describe a significant defect in the number of effector memory (EM) phenotype cells in ICOS(-/-) and ICOSL(-/-) mice that becomes progressively more dramatic as the mice age...
  74. ncbi The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
    Hisaya Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 175:2340-8. 2005
    ..These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ T(FH) cells in vivo...

Patents1

  1. Gl50 molecules and uses therefor
    Patent Number: WO0121796-A2; Date:2001-03-29