Htr1b

Summary

Gene Symbol: Htr1b
Description: 5-hydroxytryptamine (serotonin) receptor 1B
Alias: 5-hydroxytryptamine receptor 1B, 5-HT-1B, 5-HT1B receptor, 5-HT<1B> receptor, serotonin receptor 1B
Species: mouse

Top Publications

  1. ncbi Reduced sensitivity to ethanol reward, but not ethanol aversion, in mice lacking 5-HT1B receptors
    F O Risinger
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland 97201 3098, USA
    Alcohol Clin Exp Res 20:1401-5. 1996
  2. ncbi Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT(1B) autoreceptors: a microdialysis study in knockout mice
    Lotte De Groote
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychopharmacology (Berl) 162:419-24. 2002
  3. ncbi Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors
    Agnes Janoshazi
    Centre National de la Recherche Scientifique UMR7104, Illkirch, France
    Mol Pharmacol 71:1463-74. 2007
  4. ncbi Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development
    A L Upton
    Institut National de la Santé et de la Recherche Médicale U106, Hopital de la Salpetriere, 75651 Paris Cedex 13, France
    J Neurosci 19:7007-24. 1999
  5. ncbi Juvenile 5HT(1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT(1A) receptor activation
    Bassem F El-Khodor
    PsychoGenics Inc, Hawthorne, USA
    Int J Dev Neurosci 22:405-13. 2004
  6. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
  7. ncbi Enhanced aggressive behavior in mice lacking 5-HT1B receptor
    F Saudou
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, U184 de l INSERM, Faculte de Medecine, Strasbourg, France
    Science 265:1875-8. 1994
  8. ncbi 5-HT1B receptor knock out--behavioral consequences
    S Ramboz
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Behav Brain Res 73:305-12. 1996
  9. ncbi Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
    B A Rocha
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth 76107, USA
    Nature 393:175-8. 1998
  10. pmc Serotonin receptor 1A knockout: an animal model of anxiety-related disorder
    S Ramboz
    Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 95:14476-81. 1998

Research Grants

Scientific Experts

Detail Information

Publications101 found, 100 shown here

  1. ncbi Reduced sensitivity to ethanol reward, but not ethanol aversion, in mice lacking 5-HT1B receptors
    F O Risinger
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland 97201 3098, USA
    Alcohol Clin Exp Res 20:1401-5. 1996
    ....
  2. ncbi Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT(1B) autoreceptors: a microdialysis study in knockout mice
    Lotte De Groote
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Psychopharmacology (Berl) 162:419-24. 2002
    ..Serotonin (5-HT) autoreceptors regulate extracellular 5-HT levels and have been suggested to limit the effects of acute treatment with selective serotonin reuptake inhibitors (SSRIs)...
  3. ncbi Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors
    Agnes Janoshazi
    Centre National de la Recherche Scientifique UMR7104, Illkirch, France
    Mol Pharmacol 71:1463-74. 2007
    ..In conclusion, these data demonstrate that coexpression of 5-HT(1B) and 5-HT(2B) receptors influences the internalization pathways and kinetics of both receptors...
  4. ncbi Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development
    A L Upton
    Institut National de la Santé et de la Recherche Médicale U106, Hopital de la Salpetriere, 75651 Paris Cedex 13, France
    J Neurosci 19:7007-24. 1999
    ..A hypothesis is proposed whereby, during normal development, localized SERT expression could confer specific neurotransmission properties on a subset of RGCs and could be important in the fine-tuning of retinal projections...
  5. ncbi Juvenile 5HT(1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT(1A) receptor activation
    Bassem F El-Khodor
    PsychoGenics Inc, Hawthorne, USA
    Int J Dev Neurosci 22:405-13. 2004
    ....
  6. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
    ..of the somatosensory cortex, expression of appropriate firing properties, and the expression of the Htr1a and Htr1b autoreceptors...
  7. ncbi Enhanced aggressive behavior in mice lacking 5-HT1B receptor
    F Saudou
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, U184 de l INSERM, Faculte de Medecine, Strasbourg, France
    Science 265:1875-8. 1994
    ..Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT1B receptors in aggressive behavior...
  8. ncbi 5-HT1B receptor knock out--behavioral consequences
    S Ramboz
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Behav Brain Res 73:305-12. 1996
    ....
  9. ncbi Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
    B A Rocha
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth 76107, USA
    Nature 393:175-8. 1998
    ..This altered state might be responsible for their increased vulnerability to cocaine...
  10. pmc Serotonin receptor 1A knockout: an animal model of anxiety-related disorder
    S Ramboz
    Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 95:14476-81. 1998
    ....
  11. ncbi 5-HT1B receptor knock-out mice exhibit increased exploratory activity and enhanced spatial memory performance in the Morris water maze
    G Malleret
    Laboratoire de Neurosciences Comportementales et Cognitives, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5807, Universite de Bordeaux 1, 33405 Talence Cedex, France
    J Neurosci 19:6157-68. 1999
    ..The 5-HT1B receptor may be a key target for serotonin in the modulation of cognitive behavior, particularly in situations involving a high cognitive demand...
  12. ncbi Altered serotonin and dopamine metabolism in the CNS of serotonin 5-HT(1A) or 5-HT(1B) receptor knockout mice
    A R Ase
    Department de Physiologie, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 75:2415-26. 2000
    ..Thus, markedly different alterations in CNS monoamine metabolism may contribute to the opposite behavioral phenotypes of these two knockouts...
  13. ncbi Regulation of central synaptic transmission by 5-HT(1B) auto- and heteroreceptors
    H Morikawa
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Pharmacol 58:1271-8. 2000
    ..Furthermore, this study underscores the role played by presynaptic 5-HT(1B) receptors in mediating the effects of cocaine on synaptic transmission...
  14. ncbi Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice
    N Salichon
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 146, Institut Curie, 91405 Orsay, France
    J Neurosci 21:884-96. 2001
    ..Finally, because the 5-HT1B receptor inhibits glutamate release, our results suggest that visual and somatosensory projections must release glutamate for proper segregation...
  15. ncbi Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice, and of serotonin innervation in the 5-HT1B knockout
    A R Ase
    Departement de Physiologie, Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 78:619-30. 2001
    ..v) These increases in density of 5-HT innervation provide the first evidence for a negative control of 5-HT neuron growth mediated by 5-HT1B receptors...
  16. ncbi 5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function
    Peter G Clifton
    Experimental Psychology, University of Sussex, Brighton BN1 9QG, UK
    Eur J Neurosci 17:185-90. 2003
    ..These results demonstrate that compensatory adaptations to the constitutive loss of 5-HT1B receptors may be an important determinant of the altered response of 5-HT1B KO mice to a variety of pharmacological challenges...
  17. ncbi Spatial learning in the 5-HT1B receptor knockout mouse: selective facilitation/impairment depending on the cognitive demand
    Marie Christine Buhot
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 5106, Laboratoire de Neurosciences Cognitives, Universite de Bordeaux 1, 33405 Talence, France
    Learn Mem 10:466-77. 2003
    ..This 5-HT1BKO mouse story highlights the problem of the potential existence of "global memory enhancers."..
  18. ncbi Alterations in 5-HT1B receptor function by p11 in depression-like states
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA
    Science 311:77-80. 2006
    ..p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant...
  19. ncbi Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development
    A Bonnin
    Department of Pharmacology, Vanderbilt University, 8114 MRBIII, 465 21st Avenue South, Nashville, TN 37232 8548, USA
    Neuroscience 141:781-94. 2006
    ..Moreover, all members of the 5-HT1 receptor class are strongly and transiently expressed in the embryonic dorsal thalamus, which suggests a potential role for serotonin in early thalamic development...
  20. ncbi Serotonin modulates the response of embryonic thalamocortical axons to netrin-1
    Alexandre Bonnin
    Department of Pharmacology, Vanderbilt University, 465 21st Ave South, Nashville, Tennessee 37232, USA
    Nat Neurosci 10:588-97. 2007
    ..These data demonstrate that serotonergic signaling has a previously unrecognized role in the modulation of axonal responsiveness to a classic guidance cue...
  21. pmc Sucrose intake and fasting glucose levels in 5-HT(1A) and 5-HT(1B) receptor mutant mice
    Anita J Bechtholt
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 3403, United States
    Physiol Behav 93:659-65. 2008
    ....
  22. pmc Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism
    Xiaoqun Zhang
    Section of Translational Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institute, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:2163-8. 2008
    ..These data reveal an L-DOPA-induced negative-feedback mechanism, whereby the serotonin system may influence the symptomatology of Parkinsonism...
  23. doi Regionally selective changes in neurotransmitter receptors in the brain of the 5-HT1B knockout mouse
    A R Ase
    Department of Physiology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Chem Neuroanat 35:356-63. 2008
    ..It is likely that these latter changes underlie some aspects of the addictive behavior of the 5-HT1B KO mouse...
  24. pmc Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers
    L Maroteaux
    Laboratoire de Genetique Moleculaire des Eucaryotes, Institut National de la Sante et de la Recherche Medicale, Faculte de Medecine, Strasbourg, France
    Proc Natl Acad Sci U S A 89:3020-4. 1992
    ..The predominant expression of the 5HT1B receptor in the striatum and cerebellum points to an involvement of this receptor in motor control...
  25. ncbi Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice
    J J Lucas
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 18:5537-44. 1998
    ..Our results thus demonstrate that stimulation of 5-HT1B receptors is required for fenfluramine-induced anorexia and suggest a role for the PVN, CeA, and BNST in mediating this effect...
  26. ncbi Behavioral genetics. Fickle mice highlight test problems
    M Enserink
    Science 284:1599-600. 1999
  27. ncbi Genetics of alcoholism: a review of recent studies in human and animal models
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Addict 8:261-78. 1999
    ..Through the development of congenic lines and transgenic and knock-out animals, candidate genes can be identified and evaluated for their role in alcohol preference...
  28. ncbi Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition
    S C Dulawa
    Department of Neuroscience, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 22:650-9. 2000
    ..Findings suggest that 5-HT(1B) receptor activation decreases PPI and habituation, and 5-HT(1A) receptor activation increases PPI in mice...
  29. ncbi Anxiolytic-like actions of toluene in the burying behavior and plus-maze tests: differences in sensitivity between 5-HT(1B) knockout and wild-type mice
    C Lopez-Rubalcava
    Seccion de Terapeutica Experimental, Departamento de Farmacologia y Toxicologia, CINVESTAV, P O Box 22026, 14000 D F, Mexico, Mexico
    Behav Brain Res 115:85-94. 2000
    ..Data are discussed in terms of toluene's mechanisms of action and on differences between WT and KO animals...
  30. pmc Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase
    S Chiavegatto
    Department of Neurology, Division of NeuropathologyThe Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 98:1277-81. 2001
    ..These results indicate an important role for NO in normal brain 5-HT function and may have significant implications for the treatment of psychiatric disorders characterized by aggressiveness and impulsivity...
  31. ncbi Genetic regulation of extracellular serotonin by 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) autoreceptors in different brain regions of the mouse
    D A Knobelman
    Department of Pharmacology and Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6140, USA
    J Pharmacol Exp Ther 298:1083-91. 2001
    ....
  32. ncbi Impulsive-like behavior in differential-reinforcement-of-low-rate 36 s responding in mice depends on training history
    Tommy Pattij
    Department of Anatomy, University Medical Center St Radboud, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    Neurosci Lett 354:169-71. 2004
    ..Taken together, the present data suggest that impulsive-like responding in the DRL 36 s procedure in mice depends on prior behavioral history...
  33. ncbi Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP
    Prakasham Rumajogee
    Laboratoire de Neurobiologie des Signaux Intercellulaires, CNRS UMR 7101, Universite Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France
    Eur J Neurosci 19:937-44. 2004
    ....
  34. ncbi Tonic regulation of satiety by 5-HT receptors in the mouse: converging evidence from behavioural and c-fos immunoreactivity studies?
    Michelle D Lee
    School of Life Sciences, University of Sussex, Brighton, Sussex BN1 9QG, UK
    Eur J Neurosci 19:3017-25. 2004
    ..These results suggest that the activation of 5-HT(1B) receptors is an important component of endogenous satiation mechanisms in the mouse...
  35. ncbi Attack behaviors in mice: from factorial structure to quantitative trait loci mapping
    Pierre L Roubertoux
    Genetique, Neurogénétique, Comportement, CNRS Université de Parìs V, then P3M CNRS Université de la Méditerranée, Marseille, France
    Eur J Pharmacol 526:172-85. 2005
    ....
  36. ncbi Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice
    A Mekontso-Dessap
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 651, Departement de Physiologie, Universite Paris XII, CHU Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Circulation 113:81-9. 2006
    ..Here we investigated whether 5-HTT-deficient (5-HTT-KO) mice developed structural and/or functional cardiac abnormalities and valvulopathy...
  37. ncbi Photic entrainment is altered in the 5-HT1B receptor knockout mouse
    Patricia J Sollars
    Division of Neuroscience, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Biol Rhythms 21:21-32. 2006
    ..The 5-HT1B KO mouse may be useful for investigating the altered entrainment evident during this serious mood disorder...
  38. ncbi Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice
    Susanne Rutz
    Institute of Experimental and Clinical Pharmacology and Toxicology, Laboratory of Neuropharmacology, University of Freiburg, Hansastrasse 9A, D 79104 Freiburg, Germany
    Brain Res Bull 70:81-93. 2006
    ....
  39. doi Gap junction-mediated astrocytic networks in the mouse barrel cortex
    Vanessa Houades
    INSERM, U840, 75005 Paris, France
    J Neurosci 28:5207-17. 2008
    ..Such properties confine intercellular communication in astrocytes within a defined barrel as previously reported for excitatory neuronal circuits...
  40. ncbi [Involvement of prefrontal serotonergic neurons in methamphetamine-induced behavioral sensitization]
    Yukio Ago
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, 565 0871, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:85-91. 2008
    ..Here, we provide an overview of the roles of serotonergic neurons in the psychostimulant-induced behavioral sensitization...
  41. doi Prenatal activation of 5-HT2A receptor induces expression of 5-HT1B receptor in phrenic motoneurons and alters the organization of their premotor network in newborn mice
    Helene Bras
    Laboratoire Plasticité et Physio Pathologie de la Motricité, UMR 6196 CNRS, Universite de la Mediterranee, Marseille, France
    Eur J Neurosci 28:1097-107. 2008
    ..These results show that a prenatal 5-HT excess affects, via the overactivation of 5-HT(2A)-R, the expression of 5-HT(1B)-R in PhMns and the organization of their premotor network...
  42. doi Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease
    Terence Y C Pang
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    Hum Mol Genet 18:753-66. 2009
    ..Our findings implicate altered serotonergic signaling as the basis for the development of depression during the preclinical stages of HD...
  43. pmc 5-HT1A/1B receptors as targets for optimizing pigmentary responses in C57BL/6 mouse skin to stress
    Hua Li Wu
    New Drug Screening Center, China Pharmaceutical University, Nanjing, China
    PLoS ONE 9:e89663. 2014
    ..5-HT and 5-HTR1A/1B may constitute novel targets for therapy of skin hypopigmentation disorders, especially those worsened with stress. ..
  44. pmc Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout
    Frank Scott Hall
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio, United States of America Molecular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland, United States of America
    PLoS ONE 9:e115009. 2014
    ....
  45. pmc 5-HT1B autoreceptors differentially modulate the expression of conditioned fear in a circuit-specific manner
    Y Liu
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA Electronic address
    Neuroscience 298:436-47. 2015
    ....
  46. doi Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice
    Gyula Telegdy
    Department of Pathophysiology, Neuroscience Group of the Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary
    Behav Brain Res 233:232-6. 2012
    ....
  47. pmc FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin
    Aruna Kode
    Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 122:3490-503. 2012
    ..These observations identify FOXO1 as the molecular node of an intricate transcriptional machinery that confers the signal of duodenal-derived serotonin to inhibit bone formation...
  48. ncbi Differential effects of CGS 12066B and CP-94,253 on murine social and agonistic behaviour
    R Bell
    School of Psychology, Queen s University of Belfast
    Pharmacol Biochem Behav 52:7-16. 1995
    ..Findings are discussed in relation to 5-HT1A/1B/2C receptors involved in agonistic behaviour and anxiety...
  49. ncbi Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice
    G Pineyro
    Neurobiological Psychiatry Unit, McGill University, Montreal, Quebec, Canada
    Neuroreport 7:353-9. 1995
    ....
  50. ncbi Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors
    J C Crabbe
    Department of Veterans, Affairs Medical Center, Portland, Oregon, USA
    Nat Genet 14:98-101. 1996
    ....
  51. ncbi Gcm1, a mammalian homolog of Drosophila glial cells missing
    Y Altshuller
    Department of Pharmacological Sciences, State University of New York, Stony Brook 11794 8651, USA
    FEBS Lett 393:201-4. 1996
    ..Mouse Gcm1 demonstrates extensive similarity to Drosophila gcm but is expressed at very low levels during neuro- and gliogenesis...
  52. ncbi An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors
    Y Clement
    Pavillion Clerambault, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Brain Res 709:229-42. 1996
    ....
  53. ncbi Intravenous cocaine self-administration in mice lacking 5-HT1B receptors
    B A Rocha
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth 76107, USA
    Pharmacol Biochem Behav 57:407-12. 1997
    ..These results suggest that the 5-HT1B receptors may be implicated in the propensity to self-administer cocaine, but other mechanisms might be involved in the maintenance of cocaine self-administration...
  54. ncbi Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies
    A C Trillat
    Laboratoire de Neuropharmacologie, Faculte de Pharmacie, Universite de Paris Sud, Chatenay Malabry, France
    J Neurochem 69:2019-25. 1997
    ..These data provide in vivo evidence that, in mice, 5-HT1B, but not 5-HT1D, autoreceptors inhibit 5-HT release at nerve terminals located in the frontal cortex and ventral hippocampus...
  55. pmc Serotonin receptor knockouts: a moody subject
    D Julius
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143 0450, USA
    Proc Natl Acad Sci U S A 95:15153-4. 1998
  56. ncbi Differential addressing of 5-HT1A and 5-HT1B receptors in epithelial cells and neurons
    A Ghavami
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    J Cell Sci 112:967-76. 1999
    ..Furthermore, we conclude that our in vivo transgenic system is the only model that reconstitutes proper sorting of these receptors...
  57. ncbi Key role of 5-HT1B receptors in the regulation of paradoxical sleep as evidenced in 5-HT1B knock-out mice
    B Boutrel
    Institut National de la Sante et de la Recherche Medicale U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, 75634 Paris Cedex 13, France
    J Neurosci 19:3204-12. 1999
    ..2-1.2 mg/kg, s.c.) induced in both strains a reduction in the amount of paradoxical sleep. Altogether, these data indicate that 5-HT1B receptors participate in the regulation of paradoxical sleep in the mouse...
  58. ncbi 5-HT1B receptor-mediated presynaptic inhibition of retinal input to the suprachiasmatic nucleus
    G E Pickard
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523 1670, USA
    J Neurosci 19:4034-45. 1999
    ..The results indicate that 5-HT can reduce retinal input to the circadian system by acting at presynaptic 5-HT1B receptors located on retinal axons in the SCN...
  59. ncbi Oral operant ethanol self-administration in 5-HT1b knockout mice
    F O Risinger
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health Sciences University 97201 3098, USA
    Behav Brain Res 102:211-5. 1999
    ....
  60. ncbi Anxiety, motor activation, and maternal-infant interactions in 5HT1B knockout mice
    D Brunner
    Department of Psychology, Hunter College of the City University of New York and New York State Psychiatric Institute, 10032, USA
    Behav Neurosci 113:587-601. 1999
    ..5HT1B knockout mice of both sexes were hyperactive during both the light and the dark phases of the 24-hr cycle. Thus, 5HT1B knockout mice show reduced anxiety and are hyperactive throughout their life...
  61. ncbi Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities
    M L Pucci
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 277:R734-41. 1999
    ..These studies highlight the species-dependence of tissue expression and function of PGT and lay the groundwork for the use of the mouse as a model system for the study of PGT function...
  62. ncbi 5-HT1A and 5-HT1B receptors control the firing of serotoninergic neurons in the dorsal raphe nucleus of the mouse: studies in 5-HT1B knock-out mice
    A Evrard
    INSERM U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pité Salpêtrière, Paris, Cedex, France
    Eur J Neurosci 11:3823-31. 1999
    ..v.). Altogether, these data indicate that in the mouse, the firing of 5-HT neurons in the dorsal raphe nucleus is under both an inhibitory control through 5-HT1A receptors and an excitatory influence through 5-HT1B receptors...
  63. ncbi 5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes: further evidence using 5-HT moduline, polyclonal 5-HT1B receptor antibodies and 5-HT1B receptor knock-out mice
    H Sarhan
    Unité de Pharmacologie Neuro Immuno Endocrinienne, Institut Pasteur, Paris, France
    Naunyn Schmiedebergs Arch Pharmacol 361:12-8. 2000
    ..These observations further support our previous observations using selective agonists/antagonists, indicating that 5-HT1B receptors control the release of neuronal DA as presynaptic heteroreceptors...
  64. ncbi The cortical vibrissae representation is normal in transgenic mice lacking the 5-HT(1B) receptor
    C B Boylan
    Department of Anatomy and Neurobiology, Medical College of Ohio, 3035 Arlington Avenue, Toledo, OH, USA
    Brain Res Dev Brain Res 120:91-3. 2000
    ....
  65. pmc Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains
    H S Hain
    Department of Behavioral Neuroscience, Oregon Health Sciences University, and Research Service, Veterans Affairs Medical Center, Portland, Oregon, USA
    J Pharmacol Exp Ther 293:180-7. 2000
    ..0015), both associated with clonic seizures on chromosomes 9 (proximal) and 15 (distal). Both QTLs on chromosome 9 were sex-specific, with much larger effects on the phenotype seen in females than in males...
  66. ncbi Detection and mapping of quantitative trait loci for haloperidol-induced catalepsy in a C57BL/6J x DBA/2J F2 intercross
    N V Patel
    Department of Psychiatry, SUNY 11794 8101, USA
    Behav Genet 29:303-10. 1999
    ..from approximately 25 to 55 cM; this region contains numerous candidate genes, including Drd2, Ncam, Acat1, and Htr1b. The data also suggest the presence of a second QTL on chromosome 9 (LOD, > 3...
  67. ncbi Absence of cocaine-induced place conditioning in serotonin 1B receptor knock-out mice
    C Belzung
    LEPCO, UFR Sciences et Techniques, Parc Grandmont, F 37200 Tours, France
    Pharmacol Biochem Behav 66:221-5. 2000
    ..As other studies showed that 5-HT1B knock-out mice self-administer cocaine, these results suggest a dissociation between the psychologic state linked to self-administration and the one measured in conditioned place preference...
  68. ncbi Region-specific enhancement of basal extracellular and cocaine-evoked dopamine levels following constitutive deletion of the Serotonin(1B) receptor
    T S Shippenberg
    Integrative Neuroscience Unit, Behavioral Neuroscience Laboratory, NIH NIDA Intramural Research Program, Baltimore, Maryland, USA
    J Neurochem 75:258-65. 2000
    ....
  69. ncbi Ethanol intake is not elevated in male 5-HT(1B) receptor knockout mice
    J A Bouwknecht
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, Netherlands
    Eur J Pharmacol 403:95-8. 2000
    ..Hence, the initial finding of elevated ethanol intake in 5-HT(1B) receptor knockout mice may have been due to phenotypic differences in fluid intake...
  70. ncbi 5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response
    A Dirks
    Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Behav Brain Res 118:169-78. 2001
    ..Furthermore, it is concluded that the hyperreactivity in 1BKO mice cannot be generalized to all stimuli, including the startling stimuli used in this study, but is probably restricted to mild environmental stimuli only...
  71. ncbi Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal
    J A Bouwknecht
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, The Netherlands
    Psychopharmacology (Berl) 153:484-90. 2001
    ..5-HT1B KO mice are hyperreactive to mild stressors and this might be reflected in altered postsynaptic 5-HT1A receptor sensitivity...
  72. ncbi Absence of 5-HT(1B) receptors is associated with impaired impulse control in male 5-HT(1B) knockout mice
    J A Bouwknecht
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Utrecht, The Netherlands
    Biol Psychiatry 49:557-68. 2001
    ..The 5-HT(1B) receptor is thought to mediate aggression and impulse control. This was studied here in mice lacking 5-HT(1B) receptors (5-HT(1B) KO)...
  73. ncbi Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice
    A J Mayorga
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6140, USA
    J Pharmacol Exp Ther 298:1101-7. 2001
    ..These results suggest that 5-HT(1A) and 5-HT(1B) receptors have different roles in the modulation of the response to antidepressant drugs in the TST...
  74. ncbi Behavioural testing of standard inbred and 5HT(1B) knockout mice: implications of absent corpus callosum
    D Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Behav Brain Res 125:23-32. 2001
    ....
  75. ncbi Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935
    A Keegan
    Department of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Scotland
    Circ Res 89:1231-9. 2001
    ..In conclusion, the 5-HT(1B) receptor plays a role in the development of CHPHT. One possible mechanism may be via enhanced 5-HT(1) receptor-mediated contraction of the pulmonary arterial circulation...
  76. ncbi Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes
    J A Bouwknecht
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Physiol Behav 74:507-16. 2001
    ..Lacking this receptor increases body growth, without signs of obesity. A potential genetic background effect influencing this phenotype is discussed...
  77. ncbi Decreased G-protein coupling of serotonin 5-HT(1A) receptors in the brain of 5-HT(1B) knockout mouse
    A R Ase
    Faculte de Medecine, Departement de Physiologie, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec, Canada
    Neuropharmacology 42:941-9. 2002
    ..This could represent the first indication of a cross-talk between these two 5-HT receptor subtypes, at least in brain regions where they are co localized in the same neurons...
  78. ncbi 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis
    D D Mitsikostas
    Stroke and Neurovascular Regulation Laboratory, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA
    Cephalalgia 22:384-94. 2002
    ....
  79. ncbi Ontogeny of descending serotonergic innervation and evidence for intraspinal 5-HT neurons in the mouse spinal cord
    Bérangère Ballion
    Laboratoire de Neurobiologie des Réseaux, Université Bordeaux 1 et Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5816, Avenue des Facultes, 33405 Talence, France
    Brain Res Dev Brain Res 137:81-8. 2002
    ..Their somata lay in the gray matter around the central canal and preferentially in the ventro-median part of the ventral horn. The functional significance of these sacral 5-HT-ir neurons is discussed...
  80. ncbi 5-HT1B receptor knockout mice exhibit an enhanced response to constant light
    Patricia J Sollars
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523 1670, USA
    J Biol Rhythms 17:428-37. 2002
    ....
  81. ncbi Serotonin 1B knockout mice exhibit a task-dependent selective learning facilitation
    M Wolff
    Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Universite de Bordeaux 1, Avenue des Facultes, 33405 Talence Cedex, France
    Neurosci Lett 338:1-4. 2003
    ..These results suggest that the serotonin 1B receptor gene deletion selectively enhances learning performance when the cognitive requirement of the task is elevated...
  82. ncbi Expression of serotonin receptors in mouse oocytes and preimplantation embryos
    J Vesela
    Institute of Animal Physiology, Slovak Academy of Sciences, 040 01 Kosice, Slovak Republic
    Physiol Res 52:223-8. 2003
    ..Demonstration of the expression of 5-HT1D serotonin receptor in mouse oocytes and preimplantation embryos supports the idea of a functional serotonin (5-HT1D) receptor in early mammalian development...
  83. ncbi Operant learning and differential-reinforcement-of-low-rate 36-s responding in 5-HT1A and 5-HT1B receptor knockout mice
    Tommy Pattij
    Department of Anatomy, University Medical Center St Radboud, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    Behav Brain Res 141:137-45. 2003
    ..In contrast, 5-HT(1A) receptors appear to be involved in facilitation of autoshaping, but their role in impulsivity and prefrontal cortex-dependent learning and memory appears to be limited...
  84. ncbi Protective effect of 5-HT1B receptor gene deletion on the age-related decline in spatial learning abilities in mice
    Marie Christine Buhot
    Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Universite de Bordeaux 1, Avenue des Facultes, 33405 Talence Cedex, France
    Behav Brain Res 142:135-42. 2003
    ..The data suggest that 5-HT1BKO mice are more resistant than WT to age-related memory decline as concerns both reference/long-term and working/short-term spatial memory...
  85. pmc Delay-dependent working memory impairment in young-adult and aged 5-HT1BKO mice as assessed in a radial-arm water maze
    Mathieu Wolff
    Centre National de la Recherche Scientifique UMR 5106, Laboratoire de Neurosciences Cognitives, Universitéde Bordeaux 1, 33405 Talence Cedex, France
    Learn Mem 10:401-9. 2003
    ..These results support the idea that cholinergic-serotonergic interactions play an important role in memory processes...
  86. ncbi Modulation of serotonergic receptor signaling and cross-talk by prion protein
    Sophie Mouillet-Richard
    Différenciation cellulaire et Prions, CNRS UPR 1983 Institut André Lwoff, 7 rue Guy Moquet, BP8, 94801 Villejuif Cedex, France
    J Biol Chem 280:4592-601. 2005
    ..They provide a foundation for uncovering the impact of prion infection on serotonergic functions...
  87. ncbi Sex differences in the regulation of serotonergic transmission and behavior in 5-HT receptor knockout mice
    Michelle D Jones
    Department of Psychiatry, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 30:1039-47. 2005
    ..Therefore, female 5-HT1B receptor knockout mice demonstrate a sex-linked disinhibition of 5-HT release that sustained higher baseline levels of hippocampal 5-HT and behavioral vulnerability to 5-HT depletion...
  88. ncbi Light-induced Fos expression is attenuated in the suprachiasmatic nucleus of serotonin 1B receptor knockout mice
    Patricia J Sollars
    Division of Neuroscience, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Neurosci Lett 401:209-13. 2006
    ..These data taken together with previous data suggest that functional removal of the 5-HT1B receptor results in reduced functional light input to the SCN...
  89. ncbi Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Endocrinology 147:5893-900. 2006
    ....
  90. ncbi Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice
    Valérie Kayser
    University Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, F 75013, France
    Pain 130:235-48. 2007
    ..These results support the conclusion that the complex control of pain mechanisms by 5-HT, acting at multiple receptors, is physiologically relevant in mice...
  91. pmc Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity
    E Sibille
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 12:1042-56, 975. 2007
    ..We show that the lack of 5-HT(1B)R (Htr1b(KO) mice) induced an early age-related motor decline and resulted in decreased longevity...
  92. ncbi Changes in social instigation- and food restriction-induced aggressive behaviors and hippocampal 5HT1B mRNA receptor expression in male mice from early weaning
    Kayo Nakamura
    Laboratory of Veterinary Ethology, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Behav Brain Res 187:442-8. 2008
    ..These results suggest that manipulation of weaning time modulates adult aggressive behavior depending on the stressors imposed and that this change may involve the 5HT1B receptor system in the hippocampus...
  93. pmc Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum
    Vijay K Yadav
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell 135:825-37. 2008
    ..Serotonin acts on osteoblasts through the Htr1b receptor and CREB to inhibit their proliferation...
  94. doi Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum
    Martin Egeland
    Center for Molecular Medicine, Karolinska Institute, 17176, Stockholm, Sweden
    Neuropharmacology 61:442-50. 2011
    ..It can be concluded that p11 is anatomically positioned to modulate serotonin neurotransmission, via 5-HT(1B)R and 5-HT(4)R, in brain regions important for emotionality, cognition and locomotion...
  95. doi Characterization of 5-HT(1A/1B)-/- mice: an animal model sensitive to anxiolytic treatments
    Jean Philippe Guilloux
    Univ Paris Sud EA 3544, Faculte de Pharmacie, 5, rue JB Clement, Chatenay Malabry Cedex F 92296, France
    Neuropharmacology 61:478-88. 2011
    ..Thus, the 5-HT(1A/1B)-/- mouse model could be of great interest to unveil the mechanisms of action of the anxiolytic effects of SSRIs...
  96. ncbi Confirmation of quantitative trait loci for alcohol preference in mice
    L M Tarantino
    Intercollege Graduate Program in Genetics, The Pennsylvania State University, University Park 16802, USA
    Alcohol Clin Exp Res 22:1099-105. 1998
    ..Behav. Genet. 26:149-160, 1996) and supports the methodological argument for a multistage research design for nominating and replicating QTLs...
  97. ncbi Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice
    F O Risinger
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, 97201 3098, USA
    Alcohol Clin Exp Res 22:1234-44. 1998
    ..Some of these genes appear to influence taste sensitivity, whereas others appear to mediate sensitivity to aversive pharmacological effects of ethanol...
  98. ncbi Genetics of mouse behavior: interactions with laboratory environment
    J C Crabbe
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Science 284:1670-2. 1999
    ..For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory...
  99. ncbi Startle responses, heart rate, and temperature in 5-HT1B receptor knockout mice
    J A Bouwknecht
    Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, The Netherlands
    Neuroreport 11:4097-102. 2000
    ..Footshocks caused a mild startle-sensitization and tachycardia in both genotypes. The physiological hyper-reactivity in 5-HT1B KO mice is a subtle phenotypic difference that contrasts with the phenotypic decrease in startle reactivity...
  100. ncbi Chromosomal mapping of the psychomotor stimulant effects of cocaine in BXD recombinant inbred mice
    L L Miner
    Molecular Neurobiology Branch, NIDA ARC, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 122:209-14. 1995
    ..The largest associations for baseline activity were observed on chromosomes 5 and 9 and the largest associations for cocaine's psychomotor stimulant effects on chromosomes 3 and 17...

Research Grants3

  1. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2005
    ..This young society represents an opportunity to attract a core group of young investigators to alcohol research during their formative years. ..
  2. Genomic Characterization in Depression and Suicide.
    Etienne Sibille; Fiscal Year: 2007
    ..The training program proposes formal courses, supervised training and frequent interactions with several research groups involved in pioneering aspects of genomic research in mood disorders. [unreadable] [unreadable]..
  3. Identification of Genes for Alcohol Preference in Noninbred Rats and Mice
    Paula Bice; Fiscal Year: 2009
    ..abstract_text> ..