Hras

Summary

Gene Symbol: Hras
Description: Harvey rat sarcoma virus oncogene
Alias: H-ras, Ha-ras, Harvey-ras, Hras-1, Hras1, Kras2, c-H-ras, c-Ha-ras, c-rasHa, ras, GTPase HRas, H-Ras-1, H-ras 1 protein, Harvey rat sarcoma virus oncogene 1, c-Ha-ras p21 protein, c-Ha-ras transgene, p21ras, transforming protein P21
Species: mouse

Top Publications

  1. ncbi Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    Martin Oft
    University of California at San Francisco Comprehensive Cancer Center, Box 0875, San Francisco, California 94143 0875, USA
    Nat Cell Biol 4:487-94. 2002
  2. ncbi Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice
    Giacomo Manenti
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Oncogene 23:4495-504. 2004
  3. ncbi 14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain
    G J Clark
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 272:20990-3. 1997
  4. pmc NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840
    Jary Y Delgado
    Interdepartmental PhD Program for Neuroscience, University of California, Los Angeles, 90095, USA
    J Neurosci 27:13210-21. 2007
  5. ncbi Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
    R Bremner
    Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland
    Cell 61:407-17. 1990
  6. ncbi Distinct genetic loci control development of benign and malignant skin tumours in mice
    H Nagase
    CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow, UK
    Nat Genet 10:424-9. 1995
  7. pmc K-ras is an essential gene in the mouse with partial functional overlap with N-ras
    L Johnson
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 11:2468-81. 1997
  8. ncbi Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation
    T Manabe
    Department of Neurophysiology, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 20:2504-11. 2000
  9. pmc RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao
    S Traver
    Inserm U 528, Institut Curie Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Biochem J 350:19-29. 2000
  10. pmc Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development
    L M Esteban
    Centro de Investigacion del Cancer, IBMCC, CSIC USAL, University of Salamanca, Salamanca, Spain
    Mol Cell Biol 21:1444-52. 2001

Research Grants

Scientific Experts

Detail Information

Publications137 found, 100 shown here

  1. ncbi Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    Martin Oft
    University of California at San Francisco Comprehensive Cancer Center, Box 0875, San Francisco, California 94143 0875, USA
    Nat Cell Biol 4:487-94. 2002
    ..Here we show that during multistage tumorigenesis, discrete expression thresholds of activated Smad2 and H-ras are sequentially surpassed, driving tumour progression through distinct phases from a differentiated squamous ..
  2. ncbi Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice
    Giacomo Manenti
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Oncogene 23:4495-504. 2004
    ..with 42 tightly linked markers, including intragenic polymorphisms in five genes (Bcat1, Lrmp, Las1, Ghiso, and Kras2) and amino-acid changes in three genes (Lrmp, Las1, Lmna-rs1)...
  3. ncbi 14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain
    G J Clark
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 272:20990-3. 1997
    Although Raf-1 is a critical effector of Ras signaling and transformation, the mechanism by which Ras promotes Raf-1 activation is complex and remains poorly understood...
  4. pmc NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840
    Jary Y Delgado
    Interdepartmental PhD Program for Neuroscience, University of California, Los Angeles, 90095, USA
    J Neurosci 27:13210-21. 2007
    ..Together, our results show that GluR1 phosphorylation at T840 is regulated by NMDA receptor activation and suggest that decreases in GluR1 phosphorylation at T840 may have a role in LTD...
  5. ncbi Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
    R Bremner
    Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland
    Cell 61:407-17. 1990
    Initiation of tumorigenesis in mouse skin can be accomplished by mutagenesis of the H-ras gene by treatment with chemical carcinogens...
  6. ncbi Distinct genetic loci control development of benign and malignant skin tumours in mice
    H Nagase
    CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow, UK
    Nat Genet 10:424-9. 1995
    ..On the other hand, probably a single locus on chromosome 5 affects both early and late stages of malignancy. The results indicate that benign and malignant tumours are largely under independent genetic control...
  7. pmc K-ras is an essential gene in the mouse with partial functional overlap with N-ras
    L Johnson
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 11:2468-81. 1997
    Mammalian ras genes are thought to be critical in the regulation of cellular proliferation and differentiation and are mutated in approximately 30% of all human tumors. However, N-ras and H-ras are nonessential for mouse development...
  8. ncbi Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation
    T Manabe
    Department of Neurophysiology, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 20:2504-11. 2000
    The proto-oncogene ras plays a critical role in cell proliferation and differentiation. However, ras genes are abundantly expressed in the adult CNS, although neuronal cells normally do not proliferate...
  9. pmc RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao
    S Traver
    Inserm U 528, Institut Curie Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Biochem J 350:19-29. 2000
    In an attempt to elucidate the physiological function(s) of the Ras-related Rap proteins, we used the yeast two-hybrid system and isolated a cDNA encoding a protein that interacts with both Rap1 and Rap2, but not with Ras; the use of ..
  10. pmc Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development
    L M Esteban
    Centro de Investigacion del Cancer, IBMCC, CSIC USAL, University of Salamanca, Salamanca, Spain
    Mol Cell Biol 21:1444-52. 2001
    Mammalian cells harbor three highly homologous and widely expressed members of the ras family (H-ras, N-ras, and K-ras), but it remains unclear whether they play specific or overlapping cellular roles...
  11. ncbi A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis
    M Llanos Casanova
    Project on Cell and Molecular Biology and Gene Therapy, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, 28040 Madrid, Spain
    Cancer Res 62:3402-7. 2002
    ..A large body of evidence indicates that in this model, activation of Ha-ras is the critical event in papilloma formation, a process that involves epidermal proliferation and stroma remodeling,..
  12. ncbi Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice
    Hiroki Nagase
    The Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 63:4849-53. 2003
    ..The mouse Hras gene, located close to Skts2 on chromosome 7, had specific activating mutations in the Mus musculus allele in 23 of ..
  13. ncbi Involvement of H- and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis
    Carlos Martinez-Salgado
    Unidad de Investigacion, Hospital Universitario de Salamanca, Salamanca, Spain
    Exp Cell Res 312:2093-106. 2006
    ..TGF-beta and Ras signaling pathways are closely related: TGF-beta1 overcomes Ras mitogenic effects and Ras counteracts TGF-beta ..
  14. pmc Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling
    Nelson Nuñez Rodriguez
    Department of Oncological Sciences, The Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 26:7145-54. 2006
    R-Ras3/M-Ras is a member of the RAS superfamily of small-molecular-weight GTP-binding proteins...
  15. pmc A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
    Alberto J Schuhmacher
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Clin Invest 118:2169-79. 2008
    Germline activation of H-RAS oncogenes is the primary cause of Costello syndrome (CS), a neuro-cardio-facio-cutaneous developmental syndrome...
  16. pmc Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene
    Xu Chen
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:7979-84. 2009
    We developed mice with germline endogenous expression of oncogenic Hras to study effects on development and mechanisms of tumor initiation...
  17. pmc Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival
    Matthias Drosten
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, Madrid, Spain
    EMBO J 29:1091-104. 2010
    We have used mouse embryonic fibroblasts (MEFs) devoid of Ras proteins to illustrate that they are essential for proliferation and migration, but not for survival, at least in these cells...
  18. ncbi Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis
    K Ise
    Department of Cell Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Oncogene 19:2951-6. 2000
    To clarify the role of the H-Ras in vivo, we generated H-ras null mutant mice by gene targeting. In spite of the importance of the Ras in cell proliferation and differentiation, H-ras null mutant mice grew normally and were fertile...
  19. pmc An interaction between p21ras and heat shock protein hsp60, a chaperonin
    S Ikawa
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142
    Proc Natl Acad Sci U S A 89:2012-6. 1992
    ..In a search for proteins interacting with p21ras, we previously identified a protein of 60 kDa (p60) through use of a chemical cross-linker...
  20. ncbi Nucleotide sequence of c-H-ras-1 gene from B6C3F1 mice
    B Przybojewska
    Department of Toxicological Biochemistry, Institute of Occupational Medicine, Lodz, Poland
    Acta Biochim Pol 43:575-8. 1996
    The c-H-ras-1 gene of an B6C3F1 mouse was isolated and nucleotide sequence determined. Our study has revealed that this c-H-ras-1 gene consists of four exons, separated by three introns ranging in size from 150 to 649 bp...
  21. ncbi A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras
    H Shao
    Department of Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0230, USA
    J Biol Chem 275:26914-24. 2000
    The small GTPase Rit is a close relative of Ras, and constitutively active Rit can induce oncogenic transformation...
  22. ncbi Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy
    Michael D Wheeler
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, Curriculum in Toxicology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Gastrointest Liver Physiol 284:G302-12. 2003
    ..after partial hepatectomy (PH) involves several signaling mechanisms including activation of the small GTPases Ras and RhoA in response to mitogens leading to DNA synthesis and cell proliferation...
  23. ncbi Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system
    Jing Zhang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Blood 102:3938-46. 2003
    b>Ras signaling plays an important role in erythropoiesis...
  24. ncbi Single-molecule diffusion measurements of H-Ras at the plasma membrane of live cells reveal microdomain localization upon activation
    Piet H M Lommerse
    Department of Biophysics, Leiden Institute of Physics, Leiden University, Niels Bohrweg 2, 2333 CA Leiden, The Netherlands
    J Cell Sci 118:1799-809. 2005
    Recent studies show that the partitioning of the small GTPase H-Ras in different types of membrane microdomains is dependent on guanosine 5'-triphosphate (GTP)-loading of H-Ras...
  25. ncbi Harvey-ras gene expression and epidermal cell proliferation in dibenzo[a,l]pyrene-treated early preneoplastic SENCAR mouse skin
    Gausal A Khan
    Eppley Institute for Research in Cancer and Allied Diseases, Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Invest Dermatol 125:567-74. 2005
    ..DB[a,l]P) to the dorsal skin of SENCAR mice induces codon 61 (CAA Gln to CTA Leu) mutations in the Harvey (H)-ras gene within 12 h after treatment...
  26. ncbi Crosstalk between Pten and Ras signaling pathways in tumor development
    Minh D To
    UCSF Comprehensive Cancer Center, San Francisco, California 94115, USA
    Cell Cycle 4:1185-8. 2005
    The Pten and Ras pathways are disrupted or activated, respectively, in a substantial proportion of cancers...
  27. pmc Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2)
    Koji Shiraishi
    Department of Pharmacology, 2 319B BSB, 51 Newton Road, The University of Iowa, Iowa City, 52242 1109, USA
    Endocrinology 147:3419-27. 2006
    ..and the formation of complexes containing Shc and Sos (Son of sevenless), a guanine nucleotide exchange factor for Ras. Because a dominant-negative mutant of Shc inhibits the LHR-mediated activation of Ras and the phosphorylation of ..
  28. ncbi Constitutive activation of ras in neurons: implications for the regulation of the mammalian circadian clock
    Tsvetan Serchov
    Department of Molecular Neurobiochemistry and IGSN, Ruhr University, Bochum, Germany
    Chronobiol Int 23:191-200. 2006
    ..An upstream element of the ERK signalling route is the small intracellular membrane-anchored G-protein, Ras. In order to study its possible role in the entrainment of the circadian clock we are using transgenic gain-of-..
  29. ncbi p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways
    Xun Shang
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 282:8801-11. 2007
    ..by p200 RhoGAP is distinct from that formed by Rac or Rho activation but similar to that induced by oncogenic Ras, raising the possibility that p200 RhoGAP may engage Ras signaling...
  30. doi The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression
    Yongqing Liu
    Molecular Targets Program, James Graham Brown Cancer Center, Louisville, KY 40202, USA
    Biochem J 412:299-306. 2008
    Disruption of the Rb (retinoblastoma protein)/E2F cell-cycle pathway and Ras activation are two of the most frequent events in cancer, and both of these mutations place oncogenic stress on cells to increase DNA replication...
  31. pmc p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells
    Jan Czyzyk
    Departments of Pathology and Immunobiology
    J Biol Chem 283:23004-15. 2008
    ..In this study, we examined the role of a recently described Ras GTPase effector and repressor of the Raf/MEK/ERK cascade called impedes mitogenic signal propagation (Imp) in ..
  32. pmc Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II
    Benjamin Stieglitz
    Physikalische Chemie 1, Fakultät für Chemie und Biochemie, Ruhr Universitat Bochum, Bochum, Germany
    EMBO J 27:1995-2005. 2008
    A class of putative Ras effectors called Ras association domain family (RASSF) represents non-enzymatic adaptors that were shown to be important in tumour suppression...
  33. pmc 8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells
    Tina T Saxowsky
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 105:18877-82. 2008
    ..This system uses expression of the Ras oncogene in which an 8OG replaces guanine in codon 61...
  34. doi Neuronal Ras activation inhibits adult hippocampal progenitor cell division and impairs spatial short-term memory
    M Manns
    Molecular Neurobiochemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, FRG
    Genes Brain Behav 9:525-36. 2010
    ..the impact of those factors, we used a transgenic synRas mouse model expressing constitutively activated Valin12-Harvey Ras selectively in differentiated neurons...
  35. doi The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras
    Juan F Santibanez
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Científicas CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, 28040 Madrid, Spain
    Carcinogenesis 31:2145-54. 2010
    ..Because in this model system H-Ras activation drives tumor initiation and progression, we have assessed the effects of endoglin on the expression of H-..
  36. pmc PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D
    F J Sulzmaier
    Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA
    Oncogene 31:3547-60. 2012
    The small GTPase H-Ras is a proto-oncogene that activates a variety of different pathways including the extracellular-signal-regulated kinase (ERK)/mitogen-activated protein kinase pathway...
  37. doi Ras activation induces expression of Raet1 family NK receptor ligands
    Xi V Liu
    Immunology Programme, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456
    J Immunol 189:1826-34. 2012
    NK cells play a crucial role in innate immunity against tumors. In many human tumors, Ras is chronically active, and tumor cells frequently express ligands for the activating NK cell receptor NKG2D...
  38. pmc Oxidative stress posttranslationally regulates the expression of Ha-Ras and Ki-Ras in cultured astrocytes
    Samantha Messina
    Department of Human Sciences, Society, and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy
    Oxid Med Cell Longev 2012:792705. 2012
    Addition of hydrogen peroxide to cultured astrocytes induced a rapid and transient increase in the expression of Ha-Ras and Ki-Ras...
  39. pmc Genetic dissection of plexin signaling in vivo
    Thomas Worzfeld
    Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany
    Proc Natl Acad Sci U S A 111:2194-9. 2014
    ..In vitro studies have shown that plexins exert their effects via an intracellular R-Ras/M-Ras GTPase-activating protein (GAP) domain or by activation of RhoA through interaction with Rho guanine ..
  40. pmc Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b
    Naga Suresh Adapala
    Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, Connecticut, 06032
    J Cell Biochem 115:1277-89. 2014
    ..In addition to PI3K, the small GTPase Ras also regulates osteoclast survival...
  41. doi Relevant role of PKG in the progression of fibrosis induced by TNF-like weak inducer of apoptosis
    Paloma Martin
    Department of System Biology, Universidad de Alcala, Alcala de Henares, Madrid, Spain REDinREN Instituto de Salud Carlos III, Madrid, Spain Instituto Reina Sofía de Investigaciones Nefrológicas, Madrid, Spain
    Am J Physiol Renal Physiol 307:F75-85. 2014
    ..higher levels of the extracellular matrix protein fibronectin and decreased PKG-I expression and activity via the Ras pathway...
  42. pmc NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition
    Maria E R Garcia-Rendueles
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York
    Cancer Discov 5:1178-93. 2015
    ..Nf2 deletion or Hras mutation is insufficient for transformation, whereas their combined disruption leads to murine PDTC with increased ..
  43. doi Intracellular NF-HEV/IL-33 harbors essential roles in Ras-induced cellular transformation by contributing to cyclin D1 protein synthesis
    Satoshi Ohta
    Division of Structural Biochemistry and Medical Biochemistry, Department of Biochemistry, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke shi, Tochigi 329 0498, Japan
    Cell Signal 28:1025-36. 2016
    ..demonstrated that the expression of IL-33 was markedly enhanced in NIH-3T3 cells transformed by an oncogenic H-Ras mutant (H-Ras (G12V)), and the induced IL-33 was mainly located in the nuclei of these cells...
  44. ncbi The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development
    L Foroni
    MRC Laboratory of Molecular Biology, Cambridge, U K
    J Mol Biol 226:747-61. 1992
    ..These results suggest multiple cellular targets for the action of these proteins during development...
  45. ncbi Identification of a normal vertebrate cell protein related to the p21 src of Harvey murine sarcoma virus
    H Langbeheim
    Virology 106:292-300. 1980
  46. ncbi Chromosome mapping of murine susceptibility loci to liver carcinogenesis
    M Gariboldi
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 53:209-11. 1993
    ..An F2 population of 87 urethane-treated male A/J x C3H/He mice was scored with 83 genetic markers. Three regions, localized on chromosomes 7, 8, and 12, were found to contain putative liver tumor susceptibility genes...
  47. ncbi Ras signaling is essential for lens cell proliferation and lens growth during development
    Leike Xie
    Department of Ophthalmology, School of Medicine, University of Missouri, Columbia, MO 65212, USA
    Dev Biol 298:403-14. 2006
    ..The signaling pathways downstream of the RTKs remain to be elucidated. Here, we demonstrate the important role of Ras in lens development by expressing a dominant-negative form of Ras (dn-Ras) in the lens of transgenic mice...
  48. pmc Spatial regulation of Raf kinase signaling by RKTG
    Lin Feng
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 104:14348-53. 2007
    Subcellular compartmentalization has become an important theme in cell signaling such as spatial regulation of Ras by RasGRP1 and MEK/ERK by Sef. Here, we report spatial regulation of Raf kinase by RKTG (Raf kinase trapping to Golgi)...
  49. pmc Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome
    Hailan Hu
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Neurosci 28:7847-62. 2008
    ..Here, we report an examination of small GTPase Ras signaling and synaptic AMPA receptor (AMPA-R) trafficking in cultured slices and intact brains of wild-type and ..
  50. doi Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations
    Yue Xin Ren
    Department of Pathology and Laboratory Medicine, Children s Hospital Los Angeles, CA 90027, USA
    Cancer Res 68:6587-97. 2008
    ..Additional activation of the Ras signaling pathway leads to highly malignant tumor formation for all of the populations...
  51. pmc Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex
    Megumi Kaneko
    Department of Physiology and the Keck Center for Integrative Neurosciences, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 107:19026-31. 2010
    ..We show that a constitutively active form of H-ras (H-ras(G12V)), expressed presynaptically at excitatory synapses in mice, accelerates and enhances multiple, ..
  52. doi Steatosis induced by the accumulation of apolipoprotein A-I and elevated ROS levels in H-ras12V transgenic mice contributes to hepatic lesions
    Ai Guo Wang
    Laboratory Animal Center, Dalian Medical University, Dalian 116044, People s Republic of China
    Biochem Biophys Res Commun 409:532-8. 2011
    ..The steatosis, in turn, promotes the development of hepatic lesions induced by H-ras12V oncogene...
  53. pmc The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors
    Sami Ben Hamida
    Ernest Gallo Research Center and Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 32:15849-58. 2012
    ..Here, we report that the GTP binding protein, H-Ras in the nucleus accumbens (NAc) plays a key role in neuroadaptations that underlie excessive alcohol-drinking ..
  54. doi Ras signaling is essential for skin development
    M Drosten
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Spanish National Cancer Research Center, Madrid, Spain
    Oncogene 33:2857-65. 2014
    ..Here we deleted all three Ras loci (H-Ras, N-Ras and K-Ras) from keratinocytes in vitro as well as specifically from the epidermis in mice using ..
  55. pmc Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation
    Alice F Goodwin
    Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology
    Hum Mol Genet 23:682-92. 2014
    ..One of these conditions, Costello syndrome (CS), is typically caused by an activating de novo germline mutation in HRAS and is characterized by a wide range of cardiac, musculoskeletal, dermatological and developmental abnormalities...
  56. pmc Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S
    Lu Huang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 10:e0123918. 2015
    In many different human cancers, one of the HRAS, NRAS, or KRAS genes in the RAS family of small GTPases acquires an oncogenic mutation that renders the encoded protein constitutively GTP-bound and thereby active, which is well ..
  57. ncbi The rat gene map
    C Szpirer
    Curr Top Microbiol Immunol 137:33-8. 1988
  58. pmc Transcriptomal profiling of site-specific Ras signals
    Lorena Agudo-Ibáñez
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas CSIC, Departamento de Biologia Molecular, Unidad de Biomedicina, CSIC Universidad de Cantabria, Santander, Spain
    Cell Signal 19:2264-76. 2007
    b>Ras proteins are distributed in distinct plasma-membrane microdomains and endomembranes...
  59. pmc Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins
    Berta Casar
    Departamento de Biologia Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas IDICAN Universidad de Cantabria, Santander, 39011 Cantabria, Spain
    Mol Cell Biol 29:1338-53. 2009
    Subcellular localization influences the nature of Ras/extracellular signal-regulated kinase (ERK) signals by unknown mechanisms...
  60. pmc Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient
    T Sekiya
    Proc Natl Acad Sci U S A 81:4771-5. 1984
    ..patient and maintained in nude mice has been cloned in its biologically active form and identified as the c-Ha-ras-1 gene, a homologue of the viral Ha-ras gene...
  61. ncbi Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)
    C A Kozak
    Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 25:66-72. 1995
    ..Western blotting indicates that despite high sequence conservation in human and mouse, the TARBP2 protein differs in apparent size in primate and rodent cells...
  62. ncbi Reassignment of the H-ras-1 gene to the Hbb-terminus region of mouse chromosome 7
    A B Bianchi
    University of Texas, M D Anderson Cancer Center, Smithville 78957
    Mamm Genome 4:220-2. 1993
  63. pmc Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
    C S Mason
    CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB
    EMBO J 18:2137-48. 1999
    ..Expression of Raf-1 with oncogenic Ras gives predominantly S338 phosphorylation, whereas activated Src gives predominantly Y341 phosphorylation...
  64. ncbi Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras
    M S Tang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
    Cancer Res 60:5688-95. 2000
    ..the two metabolically formed bay-region diol epoxides of DMBA, and we have also analyzed mutations in the H-ras gene from tumors induced by these compounds...
  65. pmc Ecdysone-inducible expression of oncogenic Ha-Ras in NIH 3T3 cells leads to transient nuclear localization of activated extracellular signal-regulated kinase regulated by mitogen-activated protein kinase phosphatase-1
    David Plows
    Institute for Biological Research and Biotechnology, National Hellenic Research Foundation, 116 35 Athens, Greece
    Biochem J 362:305-15. 2002
    The Ras family of GTP-binding proteins are key transducers of extracellular signals, particularly through the mitogen-activated protein kinase (MAPK) pathway...
  66. ncbi RabGEF1 is a negative regulator of mast cell activation and skin inflammation
    See Ying Tam
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 5:844-52. 2004
    ..Here we report that the regulatory protein RabGEF1 bound to Ras and negatively regulated Ras activation and its 'downstream' effector pathways in Fc epsilon RI-dependent mast cell ..
  67. doi Ras signalling regulates differentiation and UCP1 expression in models of brown adipogenesis
    Maria Murholm
    Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Biochim Biophys Acta 1800:619-27. 2010
    The Ras/Raf/MEK/ERK pathway has been recognised as an important signalling module in adipogenesis and adipocyte function, but whether it promotes or inhibits the formation of fat cells has not been reconciled.
  68. ncbi H-ras up-regulates expression of BNIP3
    Wojciech Kalas
    Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Anticancer Res 31:2869-75. 2011
    ..Despite the postulated role of BNIP3 in the regulation of survival of cancer cells, the influence of oncogenic transformation on BNIP3 expression is unclear...
  69. pmc Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors
    Christopher P Vellano
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 288:3620-31. 2013
    ..signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates heterotrimeric G protein and H-Ras signaling pathways...
  70. pmc Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43
    Eryan Kong
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892 1830, USA
    J Biol Chem 288:9112-25. 2013
    ..APT1) and APT2 are cytosolic enzymes that catalyze depalmitoylation of membrane-anchored, palmitoylated H-Ras and growth-associated protein-43 (GAP-43), respectively...
  71. ncbi Oncogene-induced liver neoplasia in transgenic mice
    E P Sandgren
    Laboratory of Reproductive Physiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104
    Oncogene 4:715-24. 1989
    ..of hepatocarcinogenesis were generated by directing the expression of SV40 T-antigens, an oncogenic mutant of c-H-ras, or c-myc to the liver of transgenic mice using the albumin enhancer/promoter...
  72. ncbi The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse
    J E Brissenden
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Exp Cell Res 174:302-8. 1988
    ..4----p15.5. The mouse Rrml locus was assigned to chromosome 7, where it forms part of a conserved syntenic group of at least seven other genes assigned to human chromosome band 11p15...
  73. ncbi Chromosomal mapping of beta-globin and albino loci in the domestic cat. A conserved mammalian chromosome group
    S J O'Brien
    J Hered 77:374-8. 1986
    ..The placement of the albino locus on conserved syntenic groups of several markers (HBB, HRAS, LDHA) in both cat and mouse strongly indicates the conservative placement of the as yet unmapped human albino ..
  74. ncbi Assignment of three rat cellular RAS oncogenes to chromosomes 1, 4, and X
    J Szpirer
    Somat Cell Mol Genet 11:93-7. 1985
    ..The rat cellular HRAS-1 gene, homologous to the Harvey sarcoma virus oncogene was assigned to chromosome 1, whereas its intron-less ..
  75. pmc Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes
    A Y Sakaguchi
    Proc Natl Acad Sci U S A 81:525-9. 1984
    ..the oncogenes of Rous sarcoma virus (v-src), avian myeloblastosis virus (v-myb), Kirsten murine sarcoma virus (v-Ki-ras), and Harvey murine sarcoma virus (v-Ha-ras) were hybridized to the DNA from mouse-Chinese hamster somatic cell ..
  76. pmc Mouse gastric mucin: cloning and chromosomal localization
    L L Shekels
    Department of Medicine, University of Minnesota, Minneapolis 55417, USA
    Biochem J 311:775-85. 1995
    ..Due to sequence similarity and predominant expression in the stomach, the MGM gene may be considered a MUC5AC homologue and named Muc5ac...
  77. ncbi Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7
    W Xu
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Genomics 26:556-62. 1995
    ....
  78. ncbi Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes
    J Santos
    Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, NY 10016
    Cytogenet Cell Genet 62:217-9. 1993
    DNA probes for the NRAS, HRAS, KRAS2, LCK, RAF1, MET, MYCL1, MYCN, MYB, ERBB2, FOS, CSF1R, and SRC protooncogene loci; the retinoblastoma gene locus (RB1); the tumor virus integration sites INT2, PVT1, and MLV12; and the locus of the ..
  79. ncbi Genetic mapping of three GABAA receptor-subunit genes in the mouse
    M Danciger
    Jules Stein Eye Institute, UCLA School of Medicine
    Genomics 16:361-5. 1993
    ..The Gabrb-1, Gabra-2 pair of genes on Chr 5 maps near the mouse "circling mutation" pi (pirouette)...
  80. pmc Multiple tumor types appear in a transgenic mouse with the ras oncogene
    R D Cardiff
    Department of Pathology, School of Medicine, University of California, Davis 95616
    Am J Pathol 142:1199-207. 1993
    A transgenic mouse strain with the zeta-globin promoter and the vHa-ras oncogene develops an array of mesenchymal and epithelial neoplasms described here...
  81. ncbi The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26
    A Elson
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 31:373-5. 1996
    ..Both isoforms have been suggested to arise from a single gene through the use of alternative promoters and 5' exons. The identification of a single PTP epsilon locus in both organisms is consistent with this suggestion...
  82. ncbi Cardiac and skeletal muscle troponin I isoforms are encoded by a dispersed gene family on mouse chromosomes 1 and 7
    J L Guenet
    Institut Pasteur de Paris, Unite de Genetique des Mammiferes, Paris, France
    Mamm Genome 7:13-5. 1996
    ..The cardiac troponin I locus (Tnni3) also mapped to Chr 7, approximately 5-10 cM from the centromere and unlinked to the fast skeletal muscle troponin I locus. Thus, the troponin I gene family is dispersed in the mouse genome...
  83. ncbi Identification of Nore1 as a potential Ras effector
    D Vavvas
    The Diabetes Unit and Medical Services and the Department of Medicine, Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 273:5439-42. 1998
    The small GTP-binding protein Ras is pivotal in transmitting growth and differentiation signals downstream of cell surface receptors...
  84. ncbi Genetic events and the role of TGF beta in epithelial tumour progression
    R J Akhurst
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    J Pathol 187:82-90. 1999
    ..The use of transgenic and gene knock-out mice has contributed greatly to knowledge in this area. The H-ras genetic locus has been shown to undergo multiple genetic changes, including mutagenic activation, amplification of ..
  85. ncbi Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasiveness
    Z Tang
    Liver Cancer Institute, Shanghai Medical University, China
    Chin Med J (Engl) 111:313-8. 1998
    ..To make a better understanding of the molecular mechanisms involved in recurrence and metastasis of the hepatocellular carcinoma (HCC), some invasion related oncogenes, and growth factors have been investigated...
  86. ncbi Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas
    H Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Cancer Res 61:3826-36. 2001
    Activation of the p21-ras signaling pathway from aberrantly expressed receptors promotes the growth of malignant human astrocytomas...
  87. ncbi The Tg.AC (v-Ha-ras) transgenic mouse: nature of the model
    R W Tennant
    National Institute of Environmental Health Sciences, Laboratory of Environmental Carcinogenesis and Mutagenesis, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 29:51-9. 2001
    The Tg.AC (v-Ha-ras) transgenic mouse model provides a reporter phenotype of skin papillomas in response to either genotoxic or nongenotoxic carcinogens. In common with the conventional bioassay, the Tg...
  88. ncbi The rasH2 transgenic mouse: nature of the model and mechanistic studies on tumorigenesis
    N Tamaoki
    Tokai University School of Medicine, Central Institute for Experimental Animals, Miyamae, Kawasaki, Japan
    Toxicol Pathol 29:81-9. 2001
    The rasH2 mouse is a hemizygous transgenic mouse carrying the c-Ha-ras oncogene and that gene's promotor/enhancer within the genetic background of a BALB/cByJ x C57BL/6J F1 mouse...
  89. ncbi Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice
    R S Okoji
    Center for Occupational and Environmental Health, UCLA School of Public Health, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Carcinogenesis 23:777-85. 2002
    ..the role of a methyl-deficient diet in combination with sodium arsenite on the genomic methylation status and Ha-ras methylation status of C57BL/6J male mice hepatic DNA...
  90. ncbi Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis
    Aya Leder
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Ave, Boston, Massachusetts, MA 02115, USA
    Oncogene 21:6657-68. 2002
    ..AC transgene (consisting of v-Ha-Ras driven by an embryonic zeta-globin promoter) would not ordinarily be expected to develop skin and other adult ..
  91. ncbi G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway
    Jacques T Weissman
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    Oncogene 23:241-9. 2004
    b>Ras proteins mediate the proliferative effects of G-protein-coupled receptors (GPCRs), but the role of Rap proteins in GPCR signaling is unclear...
  92. ncbi Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts
    Yangmi Lim
    Department of Life Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 279:29060-5. 2004
    ..FAK phosphorylation at tyrosine 861 was increased in both constitutively H-Ras-transformed and H-Ras-inducible NIH3T3 cells, in parallel with cell transformation...
  93. ncbi Activated H-Ras regulates hematopoietic cell survival by modulating Survivin
    Seiji Fukuda
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Walther Cancer Institute, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 323:636-44. 2004
    Survivin expression and Ras activation are regulated by hematopoietic growth factors...
  94. ncbi Identification of PSD-95 palmitoylating enzymes
    Masaki Fukata
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Neuron 44:987-96. 2004
    ..P-PATs) showed substrate specificity, as they did not all enhance palmitoylation of Lck, SNAP-25b, Galpha(s), or H-Ras in cultured cells...
  95. ncbi Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy)
    Luca Lambertini
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:292-9. 2005
    ..In the present study, we evaluated the protein expression of p53 and PCNA and DNA mutations of p53 and H-ras genes in both hyperplastic and neoplastic squamous cell lesions from the NTP study...
  96. ncbi Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites
    Valery Krizhanovsky
    Department of Cell and Animal Biology, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Mol Neurosci 28:211-29. 2006
    ..enrichment and clustering of MATH1-binding E-boxes only in a subset of differentially expressed genes (Nr2f6, Hras1, and Hes5) in both mouse and man...
  97. pmc Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis
    Lan Mo
    Department of Urology, New York University Cancer Institute, New York University School of Medicine, New York, New York, USA
    J Clin Invest 117:314-25. 2007
    Although ras is a potent mitogenic oncogene, its tumorigenicity depends on cellular context and cooperative events...
  98. ncbi Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts
    Takahiro Kanno
    Division of Oral and Maxillofacial Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, Science of Physical Functions, Kyushu Dental College, Fukuoka, Japan
    J Cell Biochem 101:1266-77. 2007
    ..Small interfering RNA (siRNA) targeting Rous sarcoma kinase (RAS), an upstream regulator of both ERK1/2 and p38 MAPKs, inhibited stretch-induced ERK1/2 activation, but not ..
  99. ncbi Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis
    Sangjun Lee
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 46:949-57. 2007
    ..Deregulation of bcl-2 and ras family members is commonly observed in NMSC...
  100. ncbi The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression
    Mihalis Verykokakis
    Medical School, University of Crete and Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Crete, 710 03, Greece
    J Biol Chem 282:30285-94. 2007
    The ERF transcriptional repressor is a downstream effector of the RAS/ERK pathway that interacts with and is directly phosphorylated by ERKs in vivo and in vitro...
  101. pmc Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2
    Jinhong Huang
    Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Cell Biol 179:539-52. 2007
    ..Here, we report that a brain-specific Ras guanine nucleotide exchange factor (RasGEF) carrying two kinase non-catalytic C-lobe domains (KINDs), very-KIND (v-..

Research Grants2

  1. Cell type gene delivery and alcoholic liver disease
    Michael Wheeler; Fiscal Year: 2006
    ..In addition, through didactic training, and interactions with his mentor and key faculty, the applicant will acquire new skills that will allow him to become a successful member of the alcohol research community. ..
  2. Analysis and Identification of Skin Cancer in Mice
    Hiroki Nagase; Fiscal Year: 2008
    ..In the long term, understanding the genetic load which leads to cancer susceptibility in the human population will provide rational alternatives to cancer prevention, screening and risk assessment. [unreadable] [unreadable]..