Hoxd4

Summary

Gene Symbol: Hoxd4
Description: homeobox D4
Alias: 6030436D05Rik, Hox-4.2, Hox-5.1, homeobox protein Hox-D4, homeo box D4, homeobox protein Hox-4.2, homeobox protein Hox-5.1
Species: mouse

Top Publications

  1. ncbi Location of mouse and human genes corresponding to conserved canine olfactory receptor gene subfamilies
    E A Carver
    Life Sciences Division, Oak Ridge National Laboratory, P O Box 2009, Oak Ridge, Tennessee 37831 8077, USA
    Mamm Genome 9:349-54. 1998
  2. ncbi Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression
    M Ikeya
    Center for Molecular and Developmental Biology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo ku, 606 8502, Kyoto, Japan
    Mech Dev 103:27-33. 2001
  3. ncbi The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression
    N M van der Lugt
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Mech Dev 58:153-64. 1996
  4. ncbi Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis
    Christof Nolte
    McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada H3G 1Y6
    Dev Biol 299:582-93. 2006
  5. ncbi Murine hoxd4 expression in the CNS requires multiple elements including a retinoic acid response element
    F Zhang
    McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Quebec H3G 1Y6, Montreal, Canada
    Mech Dev 96:79-89. 2000
  6. ncbi Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: evidence for unique and redundant function
    G S Horan
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 169:359-72. 1995
  7. ncbi Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed
    G S Horan
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:1667-77. 1995
  8. pmc Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2
    M S Featherstone
    Laboratoire de Genetique Moleculaire des Eucaryotes, Unité 184 de l Institut National de la Santé et de la Recherche Médicale, Faculte de Medicine, Strasbourg, France
    Proc Natl Acad Sci U S A 85:4760-4. 1988
  9. pmc Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations
    F Spitz
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland
    Genes Dev 15:2209-14. 2001
  10. ncbi Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation
    S J Gaunt
    Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
    Development 107:131-41. 1989

Research Grants

  1. FOLATE AND HOX GENES IN CRANIOFACIAL DEVELOPMENT
    Claudia Kappen; Fiscal Year: 2003
  2. Genome-wide discovery of beta cell gene control elements
    Claudia Kappen; Fiscal Year: 2004
  3. Genetic dissection of skeletal patterning
    Claudia Kappen; Fiscal Year: 2006
  4. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    CLAUDIA T KAPPEN; Fiscal Year: 2010

Scientific Experts

  • CLAUDIA T KAPPEN
  • J E Pitera
  • Nathalie Coré
  • Denis Duboule
  • Patrick Tschopp
  • Mark Featherstone
  • Mojgan Rastegar
  • Christof Nolte
  • Laura Tomás-Roca
  • Yoko Mizutani-Koseki
  • Kyo ichi Isono
  • Haruhiko Koseki
  • Basile Tarchini
  • Rushikesh Sheth
  • Laila Kobrossy
  • Shin ichiro Yasunaga
  • M S Featherstone
  • Muriel Rhinn
  • Delphine Paul
  • Thomas Montavon
  • Xiangzhi Li
  • Sze Lynn Calista Phua
  • Claudia Kruger
  • Francois Spitz
  • Kallayanee Chawengsaksophak
  • Yoshihiro Takihara
  • D Duboule
  • Marc J Geisen
  • Jun Shinga
  • Karen Niederreither
  • Jozsef Zakany
  • Pascal Dolle
  • Nicolas Pilon
  • Giovanna Zacchetti
  • T Akasaka
  • Rémi Terranova
  • Mar Lorente
  • A Folberg
  • Deborah L Guris
  • Jean René Sylvestre
  • David Lohnes
  • Erzsebet Nagy Kovacs
  • Mamoru Ishii
  • Patricia Serpente
  • Kyoichi Isono
  • Isabel Rambaldi
  • Angel Amores
  • John Postlethwait
  • P Chambon
  • Robert E Maxson
  • Henry M Sucov
  • P Dolle
  • Felix Beck
  • Wim de Graaff
  • Jacqueline Deschamps
  • Rubén Corral-San-Miguel
  • Martin Houle
  • Faustino Marin
  • Pilar Aroca
  • Luis Puelles
  • Nina Trokovic
  • Jianbo Wang
  • Marian Ros
  • Eric van den Akker
  • Emma C Collins
  • Xiaobing Jiang
  • Maria Félix Bastida
  • Marie Kmita
  • Motoaki Ohtsubo
  • Toshiaki Kurogi
  • Jun Miyoshi
  • Hugh W Brock
  • Keichiro Mihara
  • Keita Saeki
  • Miki Tanaka-Okamoto
  • Yoshinori Ohno
  • Manabu Shirai
  • Hiroyoshi Ishizaki
  • M Ikeya
  • F Spitz
  • Alix J Christen
  • D Allan
  • Thomas Lufkin
  • Bradley E Bernstein
  • Miguel Casanova
  • Laure Bridoux
  • Daisuke Yamada
  • Takehiko Kamijo
  • Takaho A Endo
  • Laurie Thevenet

Detail Information

Publications90

  1. ncbi Location of mouse and human genes corresponding to conserved canine olfactory receptor gene subfamilies
    E A Carver
    Life Sciences Division, Oak Ridge National Laboratory, P O Box 2009, Oak Ridge, Tennessee 37831 8077, USA
    Mamm Genome 9:349-54. 1998
    ..Combined with recently published studies, these data link the four conserved olfactory gene subfamilies to homologous regions of the human, dog, and mouse genomes...
  2. ncbi Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression
    M Ikeya
    Center for Molecular and Developmental Biology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo ku, 606 8502, Kyoto, Japan
    Mech Dev 103:27-33. 2001
    ..These results indicate that Wnt-3a is necessary for correct anteroposterior patterning of vertebra, and that cdx-1 may be one of the mediator genes of Wnt-3a signaling in this process...
  3. ncbi The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression
    N M van der Lugt
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Mech Dev 58:153-64. 1996
    ..5 onwards. We discuss the possibility that members of the murine Polycomb-group can form multimeric protein complexes of different compositions with varying affinity or specificity for different subsets of Hox genes...
  4. ncbi Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis
    Christof Nolte
    McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada H3G 1Y6
    Dev Biol 299:582-93. 2006
    ..We have reported on a neural enhancer of Hoxd4 that directs expression in the CNS with the correct anterior border in the hindbrain...
  5. ncbi Murine hoxd4 expression in the CNS requires multiple elements including a retinoic acid response element
    F Zhang
    McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Quebec H3G 1Y6, Montreal, Canada
    Mech Dev 96:79-89. 2000
    We have identified a retinoic acid response element (RARE) within a neural enhancer located 3' to the Hoxd4 gene...
  6. ncbi Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: evidence for unique and redundant function
    G S Horan
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 169:359-72. 1995
    ..The phenotypic similarities and differences between Hoxd-4 and previously reported Hoxa-4 and Hoxb-4 mutant mice suggest that Hox gene paralogs have both redundant and unique functions...
  7. ncbi Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed
    G S Horan
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:1667-77. 1995
    ....
  8. pmc Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2
    M S Featherstone
    Laboratoire de Genetique Moleculaire des Eucaryotes, Unité 184 de l Institut National de la Santé et de la Recherche Médicale, Faculte de Medicine, Strasbourg, France
    Proc Natl Acad Sci U S A 85:4760-4. 1988
    ..In situ hybridization to sections from whole mouse embryos revealed Hox-5.1 expression in spinal cord and prevertebrae...
  9. pmc Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations
    F Spitz
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland
    Genes Dev 15:2209-14. 2001
    ..Accordingly, deletion of the entire cluster abolished axial expression, whereas recently acquired regulatory controls were preserved...
  10. ncbi Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation
    S J Gaunt
    Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
    Development 107:131-41. 1989
    ..We also propose how our new findings may help to explain any selective advantage to the vertebrates of homeo-gene duplication to form subfamilies...
  11. ncbi Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation
    P Dolle
    European Molecular Biology Laboratory, Heidelberg, FRG
    Nature 342:767-72. 1989
    ....
  12. pmc The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes
    D Duboule
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Faculte de Medecine, Strasbourg, France
    EMBO J 8:1497-505. 1989
    ..Thus, very different body plans might be achieved, both in insects and vertebrates, by evolutionarily conserved gene networks possibly displaying similar regulatory interactions...
  13. pmc Uncoupling time and space in the collinear regulation of Hox genes
    Patrick Tschopp
    Department of Zoology and Animal Biology, National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Geneva, Switzerland
    PLoS Genet 5:e1000398. 2009
    ..We discuss the potential functions and evolutionary origins of these mechanisms, as well as their relationship with similar processes at work during limb development...
  14. ncbi Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene
    J C Izpisua-Belmonte
    EMBL, Heidelberg, FRG
    Development 110:733-45. 1990
    ..Like other genes of the HOX-4(5) complex, Hox-4.3 is expressed in developing limbs and gonads, suggesting that 'cluster specificity' could be a feature of the HOX network...
  15. ncbi Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns
    A Gould
    Laboratory of Developmental Neurobiology, Medical Research Council MRC National Institute for Medical Research, London, UK
    Genes Dev 11:900-13. 1997
    ..CR3 mediates transcriptional activation by multiple Hox genes, including Hoxb4, Hoxd4, and Hoxb5 but not Hoxb1...
  16. ncbi HOXD4 and regulation of the group 4 paralog genes
    A Morrison
    Division of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London, UK
    Development 124:3135-46. 1997
    ..In this study, we have used transgenic analysis of the human HOXD4 locus to identify one neural and two mesodermal 3' enhancers that are capable of mediating the proper anterior ..
  17. ncbi Characterization and retinoic acid responsiveness of the murine Hoxd4 transcription unit
    A Folberg
    McGill Cancer Centre, McGill University, 3655 Drummond St, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 272:29151-7. 1997
    We have characterized the transcription unit of a murine Hox gene in the fourth paralogous group, Hoxd4. We have identified two Hoxd4 transcription start sites by S1 analysis. The upstream promoter (P2) is 5...
  18. ncbi HOX-4 genes and the morphogenesis of mammalian genitalia
    P Dolle
    European Molecular Biology Laboratory, Heidelberg, Germany
    Genes Dev 5:1767-7. 1991
    ..We also show that genital tubercle mesenchyme can respecify pattern in the chicken wing bud. This finding reinforces the concept of the uniformity in the patterning mechanisms along the various axes of the body...
  19. ncbi Control of Hoxd genes' collinearity during early limb development
    Basile Tarchini
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Dev Cell 10:93-103. 2006
    ....
  20. ncbi The role of a retinoic acid response element in establishing the anterior neural expression border of Hoxd4 transgenes
    Christof Nolte
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Mech Dev 120:325-35. 2003
    The zebrafish hoxd4a locus was compared to its murine ortholog, Hoxd4. The sequence of regulatory elements, including a DR5 type retinoic acid response element (RARE) required for Hoxd4 neural enhancer activity, are highly conserved...
  21. pmc Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments
    Mojgan Rastegar
    McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 24:8090-103. 2004
    ..We used chromatin immunoprecipitation to detect chromatin changes at the Hoxd4 locus during neurogenesis in P19 cells and embryonic day 8.0 (E8.0) and E10.5 mouse embryos...
  22. ncbi Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation
    Patricia Serpente
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Development 132:503-13. 2005
    ..that regresses until, at later stages, it is stably maintained at the r6/r7 boundary by inputs from Hoxb4 and Hoxd4. Separate RA- and Hox-responsive enhancers mediate the two phases of Rarb expression: a regulatory mechanism ..
  23. ncbi The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres
    I J McKay
    Department of Zoology, Oxford University, UK
    Development 120:2199-211. 1994
    ..An interpretation is that the cells that would normally become specified at an early stage as r5 and r6 adopt an r4 character instead, producing an excess of r4 cells that is disposed of subsequently by cell death...
  24. ncbi Breaking colinearity in the mouse HoxD complex
    T Kondo
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Cell 97:407-17. 1999
    ..These data suggest that a regulatory element located upstream of the complex is necessary for setting up the early pattern of Hox gene colinear activation...
  25. ncbi Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression
    T Akasaka
    Department of Molecular Embryology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    Development 128:1587-97. 2001
    ..Furthermore, we show an unexpected requirement for Mel18 and Bmi1 gene products to maintain stable expression of Hox cluster genes in regions caudal to the prospective anterior expression boundaries during subsequent development...
  26. ncbi Altered retinoic acid sensitivity and temporal expression of Hox genes in polycomb-M33-deficient mice
    S Bel-Vialar
    Centre d Immunologie, INSERM CNRS, Marseille Cedex, France
    Dev Biol 224:238-49. 2000
    ..In this paper, we show that in the absence of M33, the window of Hoxd4 retinoic acid (RA) responsiveness is opened earlier and that Hoxd11 gene expression is activated earlier in ..
  27. ncbi Wnt signaling is a key mediator of Cdx1 expression in vivo
    Nicolas Pilon
    Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Development 134:2315-23. 2007
    ..As Wnt signaling is implicated in somitogenesis upstream of the Notch pathway, it is conceivable that Cdx1 might play a role in this process. However, none of the Notch pathway genes assessed was overtly affected...
  28. ncbi Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression
    F M Rijli
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, College de France, Illkirch, C U de Strasbourg, France
    Dev Dyn 201:366-77. 1994
    ..These results provide the first evidence that a targeted insertion into a Hox gene coding sequence, in the context of its own cluster, could result in misexpression of a neighbour gene of the complex...
  29. doi Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features
    Laura Tomás-Roca
    Department of Human Anatomy and Psychobiology, School of Medicine, University of Murcia, and IMIB Instituto Murciano de Investigación Biosanitaria, 30100, Murcia, Spain
    Brain Struct Funct 221:815-38. 2016
    ..Additionally, our analysis identified an internal molecular organization of the migrated pontine nuclei that reflects a differential segmental origin of their neurons as assessed by Hox gene expression. ..
  30. pmc "Self-regulation," a new facet of Hox genes' function
    Rushikesh Sheth
    Instituto de Biomedicina y Biotecnologéa de Cantabria, CSIC SODERCAN Universidad de Cantabria, Santander, Spain Institut de Recherches Cliniques de Montréal, Montreal, QC, Canada
    Dev Dyn 243:182-91. 2014
    ..The spatial colinearity is considered to rely both on local and long-range cis regulation...
  31. ncbi Location of the gene involving the small eye mutation on mouse chromosome 2 suggests homology with human aniridia 2 (AN2)
    R van der Meer-de Jong
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232
    Genomics 7:270-5. 1990
    ..The conserved linkage of the cloned markers and the similarity of the Sey/+ and AN2/+ phenotypes suggest that the gene involved in the Sey mutation is the mouse homolog of the human AN2 gene...
  32. ncbi RARgamma and Cdx1 interactions in vertebral patterning
    D Allan
    Division of Experimental Medicine, Department of Molecular Biology, Institut de Recherches Cliniques de Montreal, 110 ave des Pins, ouest, Montreal, Quebec, H2W 1R7, Canada
    Dev Biol 240:46-60. 2001
    ..This finding, together with the increased phenotypic severity of RARgamma-Cdx1 double null mutants relative to single nulls, suggests that these pathways also function in parallel, likely by converging on common targets...
  33. doi Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters
    Patrick Tschopp
    National Research Centre Frontiers in Genetics at Department of Genetics and Evolution, University of Geneva, Sciences III, Quai Ernest Ansermet 30, Geneva 4, Switzerland
    Development 139:929-39. 2012
    ....
  34. ncbi Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Cell 75:1199-214. 1993
    ..We conclude that Krox-20, although not required for the initial delimitation of r3 and r5, plays an important role in the process of segmentation governing hindbrain development...
  35. ncbi A distinct Hox code for the branchial region of the vertebrate head
    P Hunt
    MRC Laboratory of Eukaryotic Molecular Genetics, NIMR, Mill Hill, London, UK
    Nature 353:861-4. 1991
    ....
  36. pmc Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and HOXD4
    Sze Lynn Calista Phua
    School of Biological Sciences, Nanyang Technological University, Singapore
    PLoS ONE 6:e25689. 2011
    ..The murine Hoxd4 gene has been proposed to harbour two promoters, an upstream promoter P2, and a downstream promoter P1, that lie 5...
  37. pmc Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4
    Shin ichiro Yasunaga
    Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Mol Cell Biol 33:644-60. 2013
    ..These findings suggest that PcG and a subset of Hox genes compose a homeostatic regulatory system for determining expression level of geminin...
  38. ncbi Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code
    J E Pitera
    Gastroenterology Unit, Institute of Child Health, University College London, London, England
    Gastroenterology 117:1339-51. 1999
    ..We have studied the expression domains of these genes in the gut both spatially and temporally...
  39. ncbi Analysis of the Hoxd-3 gene: structure and localization of its sense and natural antisense transcripts
    M Bedford
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    DNA Cell Biol 14:295-304. 1995
    ..5 days p.c. in cDNA libraries. At 12.5 days p.c., sense and antisense transcripts colocalized in the liver. The possible role of antisense homeobox transcripts during liver and the hematopoietic development is discussed...
  40. ncbi Sequence and embryonic expression of the murine Hox-3.5 gene
    A M Geada
    Department of Cell and Structural Biology, University of Manchester, UK
    Development 116:497-506. 1992
    ..6, by a distance equal to about the length of one rhombomere. Patterns of Hox-3.5 expression within the oesophagus and spinal cord, but not the testis, are similar to those of other Hox-3 genes, Hox-3.3 and Hox-3.4...
  41. doi A regulatory archipelago controls Hox genes transcription in digits
    Thomas Montavon
    National Research Centre, Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Federale, Lausanne, Switzerland
    Cell 147:1132-45. 2011
    ....
  42. pmc Fgfr1 regulates patterning of the pharyngeal region
    Nina Trokovic
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Genes Dev 17:141-53. 2003
    ..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
  43. ncbi The mouse PcG gene eed is required for Hox gene repression and extraembryonic development
    Jianbo Wang
    Department of Genetics, CB 7264, The University of North Carolina, Chapel Hill 27599 7264, USA
    Mamm Genome 13:493-503. 2002
    ..However, genetic crosses with a Mash2 null allele suggested that Eed was not required to maintain Mash2 imprinting, but could be required in a lineage specific fashion to suppress Mash2 expression...
  44. ncbi RARbeta mediates the response of Hoxd4 and Hoxb4 to exogenous retinoic acid
    A Folberg
    McGill Cancer Centre, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Dev Dyn 215:96-107. 1999
    One action of retinoids in development is the regulation of Hox gene expression. Hoxd4 and Hoxb4 expression in the embryonic hindbrain is anteriorized by retinoic acid (RA) treatment of mid-gestation mouse embryos...
  45. pmc Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia
    Emma C Collins
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Mol Cell Biol 22:7313-24. 2002
    ..analysis of Hox gene expression by in situ hybridization showed that Af9 null embryos have posterior changes in Hoxd4 gene expression...
  46. pmc Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
    Kyoichi Isono
    Developmental Genetics Group, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama 230 0045, Japan
    Genes Dev 19:536-41. 2005
    ..Importantly, the levels of Sf3b1 in PcG complexes were decreased in Sf3b1-heterozygous embryos. These findings suggest that Sf3b1-PcG protein interaction is essential for true PcG-mediated repression of Hox genes...
  47. pmc Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes
    Kyo ichi Isono
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Tsurumi ku, Yokohama 230 0045, Japan
    Mol Cell Biol 25:6694-706. 2005
    ..Functional redundancy between Phc2 and Phc1 leads us to hypothesize that the overall level of polyhomeotic orthologues in nuclei is a parameter that is critical in enabling the class II PcG complexes to exert their molecular functions...
  48. ncbi Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest
    Mamoru Ishii
    Department of Biochemistry and Molecular Biology, Norris Cancer Hospital, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Development 132:4937-50. 2005
    ..This increase in apoptosis may contribute to the mispatterning of the cranial ganglia and the hypoplasia of the first arch...
  49. ncbi Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome
    Deborah L Guris
    The Ben May Institute for Cancer Research and Center for Molecular Oncology, The University of Chicago, Chicago, Illinois 60637, USA
    Dev Cell 10:81-92. 2006
    ..Thus, we suggest that del22q11 is a contiguous gene syndrome involving dose-sensitive interaction of CRKL and TBX1 and locally aberrant RA signaling...
  50. pmc Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll
    Rémi Terranova
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 103:6629-34. 2006
    ..These observations provide previously undescribed evidence for the in vivo relationship and SET domain dependence between histone methylation and DNA methylation on MLL target genes during embryonic development...
  51. ncbi Interplay between chromatin and trans-acting factors regulating the Hoxd4 promoter during neural differentiation
    Laila Kobrossy
    McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6 Canada
    J Biol Chem 281:25926-39. 2006
    ..In this study, we identified components of the Hoxd4 P1 promoter directing expression in neurally differentiating retinoic acid-treated P19 cells...
  52. ncbi Tshz1 is required for axial skeleton, soft palate and middle ear development in mice
    Nathalie Coré
    Institut de Biologie du Developpement de Marseille Luminy IBDML, UMR6216, CNRS, Universite de la Mediterranee, F 13288 Marseille Cedex 09, France
    Dev Biol 308:407-20. 2007
    ..Finally, we demonstrate that Tshz1 is required for the development of the soft palate...
  53. ncbi Hox gene function in vertebrate gut morphogenesis: the case of the caecum
    Giovanna Zacchetti
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Development 134:3967-73. 2007
    ..These results illuminate components of the genetic cascade necessary for the emergence of this gut segment, crucial for many vertebrates...
  54. pmc Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling
    Marc J Geisen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104, CU de Strasbourg, Illkirch, France
    PLoS Biol 6:e142. 2008
    ....
  55. pmc Expression of cartilage developmental genes in Hoxc8- and Hoxd4-transgenic mice
    Claudia Kruger
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e8978. 2010
    ..Overexpression of the homeobox transcription factors Hoxc8 and Hoxd4 causes severe cartilage defects due to delay in cartilage maturation...
  56. pmc Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes
    Xiangzhi Li
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Tsurumi ku, Yokohama 230 0045, Japan
    Mol Cell Biol 31:351-64. 2011
    ..We therefore propose a novel role for Pcl2 to modify functional engagement of PRC2 and PRC1, which could be modulated by sensing cellular circumstances...
  57. doi HOX genes are expressed in bovine and mouse oocytes and early embryos
    Delphine Paul
    Universite Catholique de Louvain, Institut des Sciences de la Vie, Embryologie Moléculaire et Cellulaire Animale, Louvain la Neuve, Belgium
    Mol Reprod Dev 78:436-49. 2011
    ..Using nested PCR, HOXD1, HOXA3, HOXD4, HOXB7, HOXB9, and HOXC9 transcripts were detected in bovine oocytes and early embryos at various frequencies ..
  58. pmc Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment
    Muriel Rhinn
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch F 67404, France
    Proc Natl Acad Sci U S A 108:16687-92. 2011
    ..These results underscore the importance of maternal retinoids in preventing congenital birth defects, and lead to a revised model of the importance of RDH10 and RALDHs in controlling embryonic RA distribution...
  59. pmc Genetic and physical mapping of the mouse Ulnaless locus
    C L Peichel
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Genetics 144:1757-67. 1996
    ..Therefore, the region that must contain the Ulnaless locus has been defined and cloned, which will be invaluable for the identification of the molecular nature of the Ulnaless mutation...
  60. pmc Hox-1.11 and Hox-4.9 homeobox genes
    A Nazarali
    Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:2883-7. 1992
    ..3 and Hox-4.2 genomic DNA revealed some differences in nucleotide sequences and in the deduced homeodomain amino acid sequences compared with the sequences that have been reported...
  61. pmc An autoregulatory element of the murine Hox-4.2 gene
    H Popperl
    McGill Cancer Centre, Montreal, Quebec, Canada
    EMBO J 11:3673-80. 1992
    ..2 gene (HOX4B) which has been shown to display spatial enhancer activity in mice and flies. These findings suggest a conserved autoregulatory mechanism for the control of Hox-4.2 expression...
  62. ncbi Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene
    T Lufkin
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Nature 359:835-41. 1992
    ..2. These results are similar to the homeotic posteriorization phenomenon generated in Drosophila by ectopic expression of genes of the homeotic complex HOM-C (refs 7-10; reviewed in ref. 3)...
  63. ncbi The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development
    P Dolle
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mech Dev 36:3-13. 1991
    ..8 is expressed in more posterodistal regions than those of its neighbour Hox-4.7. Hence, Hox-4.8 expression appears to be related to the last significant phenotypic changes towards the extremities of the embryonic body and limb axes...
  64. pmc Interspecific backcross mice show sex-specific differences in allelic inheritance
    L D Siracusa
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Genetics 128:813-21. 1991
    ..These studies provide evidence for sex-specific differences in allelic inheritance for chromosome 2 and suggest biological explanations for this form of transmission distortion...
  65. ncbi A molecular genetic linkage map of mouse chromosome 2
    L D Siracusa
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 6:491-504. 1990
    ..Comparisons between the mouse and the human genomes indicate that mouse chromosome 2 contains regions homologous to at least six human chromosomes. Mouse models for human diseases are discussed...
  66. ncbi An update of mouse and human HOX gene nomenclature
    D Duboule
    Genomics 7:458-9. 1990
  67. ncbi Forward spreading in the establishment of a vertebrate Hox expression boundary: the expression domain separates into anterior and posterior zones, and the spread occurs across implanted glass barriers
    S J Gaunt
    Cell Determination Laboratory, AFRC Babraham Institute, Cambridge, United Kingdom
    Dev Dyn 199:229-40. 1994
    ..We suggest that the posterior zone marks the source of a morphogen which is the primary activator of Hox gene expression, and we discuss possible models for the mechanism of forward spreading in expression...
  68. ncbi Roles of Hox genes: what we have learnt from gain of function and loss of function mutations in the mouse
    M Mark
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, INSERM U 184, Strasbourg, France
    C R Acad Sci III 316:995-1008. 1993
    ..Here, we discuss the phenotypes of two kinds of Hox mutant mice which show that vertebrate Hox genes are functional homologues of Drosophila genes of the HOM-C complex...
  69. pmc Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene
    H Popperl
    McGill Cancer Centre, Montreal, Quebec, Canada
    Mol Cell Biol 13:257-65. 1993
    ..In addition, the response to RA could be inhibited by expressing a dominant negative form of RAR alpha in transfected P19 EC cells. These results suggested that Hox-4.2 is a target for RAR-mediated regulation by RA...
  70. ncbi The function of Hox genes in the morphogenesis of the vertebrate limb
    D Duboule
    European Molecular Biology Laboratory, Heidelberg, FRG
    Ann Genet 36:24-9. 1993
    ..The asymmetric distribution of the Hox transcript during limb development likely reflects the final limb asymmetry...
  71. ncbi Expression of class I homeobox genes in fetal and adult murine skin
    K Detmer
    San Francisco VA Medical Center, CA 94121
    J Invest Dermatol 101:517-22. 1993
    ..The amount of Hoxb-4, -b-2, and -c-4 message in skin is relatively constant from the earliest gestational day examined (day 16) through birth at day 19. Expression of several homeobox genes is also seen in adult skin...
  72. ncbi A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton
    T Akasaka
    Immunology Branch, Center for Biomedical Science, School of Medicine, Chiba University, Japan
    Development 122:1513-22. 1996
    ....
  73. ncbi Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations
    A M Boulet
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, 84112, USA
    Dev Biol 177:232-49. 1996
    ..Therefore, this mutation is likely to cause a reduction of hoxc-5 function as well as complete loss of hoxc-4 function...
  74. ncbi Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos
    Xiaobing Jiang
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, 2250 Alcazar St, IGM240, Los Angeles, CA 90033, USA
    Mech Dev 117:115-22. 2002
    ..This suggests that an alternative tissue in the vicinity of the outflow tract of the heart responds directly to RA, and thereby induces or permits the neural crest cell lineage to initiate aorticopulmonary septation...
  75. ncbi Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice
    N Core
    Centre d Immunologie INSERM CNRS de Marseille Luminy, France
    Development 124:721-9. 1997
    ..5, leading to the hypothesis that, during development, the M33 gene might play a role in defining access to retinoic acid response elements localised in the regulatory regions of several Hox genes...
  76. ncbi Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects
    Y Takihara
    Department of Medical Genetics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Development 124:3673-82. 1997
    ..These results indicate that the rae28 gene is involved in the regulation of Hox gene expression and segment specification during paraxial mesoderm and neural crest development...
  77. pmc Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos
    J Partanen
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Genes Dev 12:2332-44. 1998
    ....
  78. ncbi Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development
    X Xu
    National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 208:293-306. 1999
    ..These data demonstrate that FGF/FGFR1alpha signals are posteriorizing factors that control node regression and posterior embryonic development...
  79. ncbi Homeobox genes: a link between development, cell cycle, and cancer?
    H L Ford
    Division of Cancer Biology, Dana Farber Cancer Institute and the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA
    Cell Biol Int 22:397-400. 1998
  80. ncbi Retinoic acid synthesis and hindbrain patterning in the mouse embryo
    K Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, CU de Strasbourg
    Development 127:75-85. 2000
    ..We conclude that RA produced by the embryo is required to generate posterior cell fates in the developing mouse hindbrain, its absence leading to an abnormal r3 (and, to a lesser extent, r4) identity of the caudal hindbrain cells...
  81. ncbi Sequence and chromosomal localization of the mouse ortholog of the human olfactory receptor gene 912-93
    S Rouquier
    IGH, CNRS UPR 1142, rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Mamm Genome 10:1172-4. 1999
  82. ncbi Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation
    Eric van den Akker
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Development 129:2181-93. 2002
    ..The function of Cdx genes in morphogenetic processes during gastrulation and tail bud extension, and their relationship with the Hox genes are discussed in the light of available data in Amphioxus, C. elegans, Drosophila and mice...
  83. ncbi Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A
    Mar Lorente
    Developmental and Cell Biology, Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Mech Dev 123:312-20. 2006
    ..In addition, YY1 forms complexes with Ring1 and other class II PcG proteins such as Rnf2 and Bmi1 in GST pull down experiments in transfected cells. These findings provide evidence for a PcG function for YY1 in vertebrates...
  84. ncbi Sequence analysis of the homeobox-containing exon of the murine Hox-4.3 homeogene
    R Sadoul
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
    Biochim Biophys Acta 1089:259-61. 1991
    ..3 gene. No other homeobox sequences were detected in this screen suggesting that the HOX-4 complex lacks paralogous genes represented in the equivalent regions of other HOX loci...
  85. ncbi Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse
    V Dupé
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP College de France, B P 163, CU de Strasbourg, France
    Development 126:5051-9. 1999
    ....
  86. ncbi Retinoic acid regulates a subset of Cdx1 function in vivo
    Martin Houle
    Department of Molecular Biology, Universite de Montreal, 110 ave des Pins, ouest, Montreal, Quebec H2W 1R7, Canada
    Development 130:6555-67. 2003
    ..These findings are consistent with a pivotal role for retinoid signalling in governing a subset of expression of Cdx1 crucial for normal vertebral patterning...
  87. pmc Cdx2 is essential for axial elongation in mouse development
    Kallayanee Chawengsaksophak
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Proc Natl Acad Sci U S A 101:7641-5. 2004
    ..The gene appears to be important in the integration of the pathways controlling embryonic axial elongation, and anterior-posterior patterning...
  88. ncbi Chromosomal localization of two cell surface-associated molecules of potential importance in development: midkine (Mdk) and basigin (Bsg)
    D Simon-Chazottes
    Unité de Génétique des Mammifères de l Institut Pasteur, Paris, France
    Mamm Genome 2:269-71. 1992
  89. ncbi New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis
    P Lonai
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    DNA 6:409-18. 1987
    ..All four homeoboxes are expressed in the mouse embryo. Of special interest is the expression of mh19, a 4.2-kb transcript of which appears to be connected to the induced differentiation of Friend erythroleukemia cells...
  90. ncbi Genetic interactions and dosage effects of Polycomb group genes in mice
    S Bel
    Centre d Immunologie INSERM CNRS de Marseille Luminy, Case 906, France
    Development 125:3543-51. 1998
    ..Our results demonstrate that in mice the Polycomb group genes act in synergy to control the nested expression pattern of some Hox genes in somitic mesodermal tissues during development...

Research Grants4

  1. FOLATE AND HOX GENES IN CRANIOFACIAL DEVELOPMENT
    Claudia Kappen; Fiscal Year: 2003
    ..Knowledge about the interactions of genes with environmental factors will be important for designing therapeutic strategies and preventive measures against craniofacial defects. ..
  2. Genome-wide discovery of beta cell gene control elements
    Claudia Kappen; Fiscal Year: 2004
    ..Together, our studies will show how speck gene expression is achieved in beta cells and provide a framework to integrate gene transcription and beta cell biology. ..
  3. Genetic dissection of skeletal patterning
    Claudia Kappen; Fiscal Year: 2006
    ..The identification of modifier loci that act on skeletal patterning will reveal new molecular mechanisms in skeletal development and has important implications for the evolution of vertebrate body plans. ..
  4. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    CLAUDIA T KAPPEN; Fiscal Year: 2010
    ..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..