Hoxb8

Summary

Gene Symbol: Hoxb8
Description: homeobox B8
Alias: Hox-2.4, homeobox protein Hox-B8, homeo box B8, homeobox protein Hox-2.4
Species: mouse

Top Publications

  1. ncbi Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions
    F Chen
    Department of Human Genetics, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City 84112, USA
    Dev Biol 181:186-96. 1997
  2. pmc Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1
    Ying Qian
    The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:1220-33. 2002
  3. pmc Using mice to model Obsessive Compulsive Disorder: From genes to circuits
    Susanne E Ahmari
    Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, United States Center for Neuroscience Program and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, United States Electronic address
    Neuroscience 321:121-37. 2016
  4. ncbi Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes
    T Fujino
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Exp Hematol 29:856-63. 2001
  5. ncbi In vivo mutagenesis of the Hoxb8 hexapeptide domain leads to dominant homeotic transformations that mimic the loss-of-function mutations in genes of the Hoxb cluster
    Olga Medina-Martinez
    Center for Extracellular Matrix, Institute of Biosciences and Technology, Texas A and M University, Houston, TX 77030
    Dev Biol 264:77-90. 2003
  6. ncbi Two phases in the establishment of HOX expression domains
    J Deschamps
    Hubrecht Laboratorium, Netherlands Institute for Developmental Biology, Utrecht
    Dev Biol 156:473-80. 1993
  7. doi Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons
    Menggui Huang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Dev Biol 322:394-405. 2008
  8. pmc DNA rearrangement of a homeobox gene in myeloid leukaemic cells
    C Blatt
    Department of Genetics, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 7:4283-90. 1988
  9. pmc Hoxb8 regulates expression of microRNAs to control cell death and differentiation
    M Salmanidis
    Cell Signalling and Cell Death Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Cell Death Differ 20:1370-80. 2013
  10. doi Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development
    Youngwook Ahn
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Dev Biol 388:134-44. 2014

Scientific Experts

  • Jacqueline Deschamps
  • Lara S Carroll
  • Susanne E Ahmari
  • R Mollard
  • Olga Medina-Martinez
  • A K Voss
  • Kyo ichi Isono
  • Yoko Mizutani-Koseki
  • Haruhiko Koseki
  • Felix Beck
  • Wim de Graaff
  • Yu ichi Fujimura
  • Mario R Capecchi
  • Laura Tomás-Roca
  • Nora E Szabo
  • Youngwook Ahn
  • J Michael Gee
  • M Salmanidis
  • Carina van Rooijen
  • Petr Tvrdik
  • Miguel Vidal
  • Yoshihiro Takihara
  • Jennifer H Mansfield
  • Soraya Yekta
  • Eric van den Akker
  • Xiangzhi Li
  • Monika Bialecka
  • Cesca van de Ven
  • E van den Akker
  • Shau Kwaun Chen
  • Kallayanee Chawengsaksophak
  • Teddy Young
  • Sylvie Forlani
  • Xianling Zhao
  • Mitsuhiro Endoh
  • Jun Shinga
  • Menggui Huang
  • Xiaoyan Liao
  • Terence D Capellini
  • Jan C Holstege
  • J Charite
  • April DeLaurier
  • Mar Lorente
  • W de Graaff
  • Eran Hornstein
  • Leping Cheng
  • Kyoichi Isono
  • Omar El-Mounayri
  • Clifford J Tabin
  • Michael T McManus
  • Brian D Harfe
  • David P Bartel
  • Hiroaki Kawasaki
  • Yuki Takada
  • Rubén Corral-San-Miguel
  • Pooja Agarwal
  • Tony Oosterveen
  • Aster H Juan
  • G L Masinde
  • Luis Puelles
  • Pilar Aroca
  • Faustino Marin
  • Artur Kania
  • Susana G Sotocinal
  • Hanns Ulrich Zeilhofer
  • Jeffrey S Mogil
  • Ronan V Da Silva
  • Jennifer M Ichida
  • Fernando R Fernandez
  • S Craig Morris
  • Karen S Wilcox
  • Joy M Greer
  • Robb Krumlauf
  • Michael N Economo
  • Nathan A Smith
  • Daniela Brunert
  • Ying Qian
  • Jianbo Wang
  • John A White
  • Matt Wachowiak
  • Hillary E Mullan
  • Sierra Palumbos
  • Pascal te Welscher
  • Maki Suzuki
  • Jason D Shepherd
  • Peter J West
  • Markus Rothermel
  • Ying Liu
  • Amy Talbot
  • N Narayan

Detail Information

Publications83

  1. ncbi Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions
    F Chen
    Department of Human Genetics, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City 84112, USA
    Dev Biol 181:186-96. 1997
    ..In particular, the sternum defects are greatly exacerbated. Interestingly, the defects in hoxb-9 and hoxa-9/ hoxb-9 mutant mice are concentrated along the axial column at points of transition between vertebral types...
  2. pmc Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1
    Ying Qian
    The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:1220-33. 2002
    ..Together, our studies demonstrate a central role for Rnx and Tlx-1 in the development of two major classes of relay sensory neurons, somatic and visceral...
  3. pmc Using mice to model Obsessive Compulsive Disorder: From genes to circuits
    Susanne E Ahmari
    Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, United States Center for Neuroscience Program and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, United States Electronic address
    Neuroscience 321:121-37. 2016
    ....
  4. ncbi Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes
    T Fujino
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Exp Hematol 29:856-63. 2001
    The homeobox gene Hoxb8 is activated in the murine myelomonocytic cell line WEHI-3B as a result of intracisternal A particle integration...
  5. ncbi In vivo mutagenesis of the Hoxb8 hexapeptide domain leads to dominant homeotic transformations that mimic the loss-of-function mutations in genes of the Hoxb cluster
    Olga Medina-Martinez
    Center for Extracellular Matrix, Institute of Biosciences and Technology, Texas A and M University, Houston, TX 77030
    Dev Biol 264:77-90. 2003
    ..To study the significance of these interactions in vivo, we have generated mice that carry mutations in the Hoxb8 hexapeptide motif...
  6. ncbi Two phases in the establishment of HOX expression domains
    J Deschamps
    Hubrecht Laboratorium, Netherlands Institute for Developmental Biology, Utrecht
    Dev Biol 156:473-80. 1993
    ....
  7. doi Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons
    Menggui Huang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Dev Biol 322:394-405. 2008
    ..Our studies therefore suggest a coordinated and hierarchical specification of a variety of neurotransmitters in dorsal spinal inhibitory neurons...
  8. pmc DNA rearrangement of a homeobox gene in myeloid leukaemic cells
    C Blatt
    Department of Genetics, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 7:4283-90. 1988
    ..4 and that this resulted in constitutive expression of the homeobox gene. It is suggested that constitutive expression of the homeobox gene may interrupt the normal development program in these leukaemic cells...
  9. pmc Hoxb8 regulates expression of microRNAs to control cell death and differentiation
    M Salmanidis
    Cell Signalling and Cell Death Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Cell Death Differ 20:1370-80. 2013
    b>Hoxb8 overexpression immortalises haematopoietic progenitor cells in a growth-factor-dependant manner and co-operates with interleukin-3 (IL-3) to cause acute myeloid leukaemia...
  10. doi Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development
    Youngwook Ahn
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Dev Biol 388:134-44. 2014
    ..Our data demonstrate that multiple RAREs cooperate to remotely regulate 5׳ Hoxb genes during CNS development, providing a new insight into the mechanisms for gene regulation within the Hox clusters...
  11. doi Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception
    Nora E Szabo
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Neurosci 35:5233-46. 2015
    ..In this study, we use the intersection of Lmx1b and Hoxb8::Cre expression in the spinal cord to genetically define nociceptive circuits...
  12. doi Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features
    Laura Tomás-Roca
    Department of Human Anatomy and Psychobiology, School of Medicine, University of Murcia, and IMIB Instituto Murciano de Investigación Biosanitaria, 30100, Murcia, Spain
    Brain Struct Funct 221:815-38. 2016
    ..Additionally, our analysis identified an internal molecular organization of the migrated pontine nuclei that reflects a differential segmental origin of their neurons as assessed by Hox gene expression. ..
  13. pmc A yeast artificial chromosome containing the mouse homeobox cluster Hox-2
    M J Rubock
    Laboratory of Genome Analysis, Imperial Cancer Research Fund, London, United Kingdom
    Proc Natl Acad Sci U S A 87:4751-5. 1990
    ..The YAC will enable us to construct modified forms of the Hox-2 cluster in yeast and to identify their effect on the phenotype of the animal in transgenic mouse strains...
  14. pmc Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/β-catenin signaling
    Lara S Carroll
    Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 142:4056-67. 2015
    ....
  15. pmc Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse
    J Michael Gee
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112 Brain Institute, University of Utah, Salt Lake City, UT 84112 MD PhD Program, University of Utah, Salt Lake City, UT 84112
    Neuron 83:1058-72. 2014
    ..Through electrophysiological and behavioral analyses, we determined that GCaMP5G expression had no major impact on nervous system performance. PC::G5-tdT will be instrumental for a variety of brain mapping experiments...
  16. ncbi The developmental expression pattern of a new murine homeo box gene: Hox-2.5
    L D Bogarad
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Dev Biol 133:537-49. 1989
    ....
  17. doi Evolutionarily conserved requirement of Cdx for post-occipital tissue emergence
    Carina van Rooijen
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Development 139:2576-83. 2012
    ..Cdx requirement for the post-head section of the axis is ancestral as it takes place in arthropods as well...
  18. ncbi Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice
    Maki Suzuki
    Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Development 129:4171-83. 2002
    ..homeotic transformations of the axial skeleton and a mild derepression of some Hox genes (Hoxb4, Hoxb6 and Hoxb8) in cells anterior to their normal boundaries of expression in the mesodermal compartment...
  19. ncbi The mouse PcG gene eed is required for Hox gene repression and extraembryonic development
    Jianbo Wang
    Department of Genetics, CB 7264, The University of North Carolina, Chapel Hill 27599 7264, USA
    Mamm Genome 13:493-503. 2002
    ..However, genetic crosses with a Mash2 null allele suggested that Eed was not required to maintain Mash2 imprinting, but could be required in a lineage specific fashion to suppress Mash2 expression...
  20. ncbi Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb
    Ying Liu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Development 129:5289-300. 2002
    ..Our data provide evidence that Gas1 acts to maintain high levels of FGF10 at the tip mesenchyme and support the proposal that Fgf10 expression in this region is crucial for maintaining Fgf8 expression in the AER...
  21. ncbi Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo
    Pooja Agarwal
    Programmes in Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Development 130:623-33. 2003
    ..These data suggest common pathways for the differentiation and growth of embryonic structures downstream of T-box genes...
  22. pmc Retinoids regulate the anterior expression boundaries of 5' Hoxb genes in posterior hindbrain
    Tony Oosterveen
    Hubrecht Laboratory, The Netherlands Institute of Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    EMBO J 22:262-9. 2003
    ..response element (RARE) was identified downstream of Hoxb5 and shown to be essential for expression of Hoxb5 and Hoxb8 reporter transgenes in the anterior neural tube...
  23. ncbi Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo
    Sylvie Forlani
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Development 130:3807-19. 2003
    ....
  24. ncbi Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer
    Aster H Juan
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Development 130:4823-34. 2003
    ..Last, our data is consistent with the position that disparate regulatory pathways are responsible for the expression of Hoxc8 in the organogenesis of somites, neural tube and limb bud...
  25. ncbi Hoxb8 is required for normal grooming behavior in mice
    Joy M Greer
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Neuron 33:23-34. 2002
    ..Genes that influence this complex behavior are unknown. We report that mice with disruptions of Hoxb8 show, with 100% penetrance, excessive grooming leading to hair removal and lesions...
  26. ncbi MicroRNA-directed cleavage of HOXB8 mRNA
    Soraya Yekta
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 304:594-6. 2004
    ..in the A, B, and C mammalian HOX clusters, has extensive, evolutionarily conserved complementarity to messages of HOXB8, HOXC8, and HOXD8. RNA fragments diagnostic of miR-196-directed cleavage of HOXB8 were detected in mouse embryos...
  27. pmc Cdx2 is essential for axial elongation in mouse development
    Kallayanee Chawengsaksophak
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Proc Natl Acad Sci U S A 101:7641-5. 2004
    ..The gene appears to be important in the integration of the pathways controlling embryonic axial elongation, and anterior-posterior patterning...
  28. ncbi MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression
    Jennifer H Mansfield
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 36:1079-83. 2004
    ..Furthermore, miR-196a negatively regulates Hoxb8, indicating that its restricted expression pattern probably reflects a role in the patterning function of the Hox ..
  29. pmc Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
    Kyoichi Isono
    Developmental Genetics Group, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama 230 0045, Japan
    Genes Dev 19:536-41. 2005
    ..Importantly, the levels of Sf3b1 in PcG complexes were decreased in Sf3b1-heterozygous embryos. These findings suggest that Sf3b1-PcG protein interaction is essential for true PcG-mediated repression of Hox genes...
  30. ncbi Regulation of smooth muscle-specific gene expression by homeodomain proteins, Hoxa10 and Hoxb8
    Omar El-Mounayri
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:25854-63. 2005
    ..reverse transcription-PCR coupled to cDNA library screening we identified two homeodomain proteins, Hoxa10 and Hoxb8, which are expressed in adult mouse smooth muscle tissues...
  31. ncbi Developmental regulation of the Hox genes during axial morphogenesis in the mouse
    Jacqueline Deschamps
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Development 132:2931-42. 2005
    ..In particular, we highlight the integration of these transducers of anteroposterior positional information into the genetic network that drives tissue generation and patterning during axial elongation...
  32. pmc Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes
    Kyo ichi Isono
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Tsurumi ku, Yokohama 230 0045, Japan
    Mol Cell Biol 25:6694-706. 2005
    ..Functional redundancy between Phc2 and Phc1 leads us to hypothesize that the overall level of polyhomeotic orthologues in nuclei is a parameter that is critical in enabling the class II PcG complexes to exert their molecular functions...
  33. ncbi The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development
    Eran Hornstein
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 438:671-4. 2005
    ..Here we show that miR-196 acts upstream of Hoxb8 and Sonic hedgehog (Shh) in vivo in the context of limb development, thereby identifying a previously observed but ..
  34. ncbi Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A
    Mar Lorente
    Developmental and Cell Biology, Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Mech Dev 123:312-20. 2006
    ..In addition, YY1 forms complexes with Ring1 and other class II PcG proteins such as Rnf2 and Bmi1 in GST pull down experiments in transfected cells. These findings provide evidence for a PcG function for YY1 in vertebrates...
  35. ncbi Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8
    Yu ichi Fujimura
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Tsurumi ku, Yokohama 230 0045, Japan
    Development 133:2371-81. 2006
    ..Hox gene expression, we have focused on the binding patterns of PcG gene products to the flanking regions of the Hoxb8 gene in expressing and non-expressing tissues...
  36. ncbi Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb
    April DeLaurier
    Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK
    Dev Biol 299:22-34. 2006
    ..In contrast, misexpression of Tbx4 in the forelimb does not result in a transformation of limb-type morphology. These results demonstrate that Pitx1, but not Tbx4, determines the morphological identity of hindlimb tissues...
  37. ncbi MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells
    Hiroaki Kawasaki
    Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Nucleic Acids Symp Ser (Oxf) . 2004
    ..In this study, we show that microRNA-196 (miR-196) inhibits HOXB8 expression in myeloid differentiation of HL 60 cells...
  38. pmc Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice
    Jan C Holstege
    Department of Neuroscience, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:6338-43. 2008
    ..Hoxb genes are expressed at high levels in the dorsal horn of the spinal cord. Hoxb8 null mutants manifest a striking phenotype of excessive grooming and hairless lesions on the lower back...
  39. doi Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome
    Terence D Capellini
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Dev Biol 321:500-14. 2008
    ....
  40. pmc Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning
    Xianling Zhao
    Development and Aging Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 19:1050-7. 2009
    ....
  41. doi Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos
    Teddy Young
    Hubrecht Institute KNAW and University Medical Center, 3584 CT Utrecht, The Netherlands
    Dev Cell 17:516-26. 2009
    ..Concomitant regulation of Cyp26a1 expression, restraining retinoic acid signaling away from the posterior growth zone, may likewise play a role in timing the trunk-tail transition...
  42. doi Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity
    Anne K Voss
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Dev Cell 17:674-86. 2009
    ..In conclusion, our data show that Moz regulates H3K9 acetylation at Hox gene loci and that RA can act independently of Moz to establish specific Hox gene expression boundaries...
  43. pmc Hematopoietic origin of pathological grooming in Hoxb8 mutant mice
    Shau Kwaun Chen
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Cell 141:775-85. 2010
    Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal, similar to behavior in humans with the obsessive-compulsive disorder spectrum disorder trichotillomania...
  44. pmc Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes
    Xiangzhi Li
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Tsurumi ku, Yokohama 230 0045, Japan
    Mol Cell Biol 31:351-64. 2011
    ..We therefore propose a novel role for Pcl2 to modify functional engagement of PRC2 and PRC1, which could be modulated by sensing cellular circumstances...
  45. ncbi Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus
    C P Hart
    Cell 43:9-18. 1985
    ....
  46. ncbi Specification of multiple vertebral identities by ectopically expressed Hoxb-8
    J Charite
    Hubrecht Laboratory, The Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
    Dev Dyn 204:13-21. 1995
    ..The results suggest that higher levels of ectopically expressed Hoxb-8 result in specification of more posterior vertebral identities...
  47. ncbi Expression of class I homeobox genes in fetal and adult murine skin
    K Detmer
    San Francisco VA Medical Center, CA 94121
    J Invest Dermatol 101:517-22. 1993
    ..The amount of Hoxb-4, -b-2, and -c-4 message in skin is relatively constant from the earliest gestational day examined (day 16) through birth at day 19. Expression of several homeobox genes is also seen in adult skin...
  48. ncbi Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation
    Eric van den Akker
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Development 129:2181-93. 2002
    ..The function of Cdx genes in morphogenetic processes during gastrulation and tail bud extension, and their relationship with the Hox genes are discussed in the light of available data in Amphioxus, C. elegans, Drosophila and mice...
  49. ncbi Characterization of the Xenopus Hox 2.4 gene and identification of control elements in its intron
    D Bittner
    Department of Biological Chemistry, University of California, Los Angeles 90024 1737
    Dev Dyn 196:11-24. 1993
    ..The short distance between the end of the Hox 2.4 cDNA and the start site of the neighboring gene in the complex raises the possibility that this transcriptional element might be shared by two Hox genes...
  50. ncbi Altering the spatial determinations in the mouse embryos by manipulating the Hox genes
    L Tiret
    Unité d Embryologie Moléculaire, Institut Pasteur, Paris, France
    C R Acad Sci III 316:1009-24. 1993
    ..Expression of some related Hox genes in Hoxc-8 homozygous mutants is not altered, suggesting the absence of genetic interregulations between these genes...
  51. ncbi Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures
    J Charite
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
    Cell 78:589-601. 1994
    ..Besides other alterations, posterior homeotic transformations of axial structures were observed, involving the first spinal (Froriep's) ganglion and several cervical vertebrae...
  52. ncbi Hox genes and the evolution of vertebrate axial morphology
    A C Burke
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 121:333-46. 1995
    ..The recognition of mechanistic homology supports the historical homology of basic patterning mechanisms between all organisms that share these genes...
  53. pmc Gain of function mutations for paralogous Hox genes: implications for the evolution of Hox gene function
    R A Pollock
    Department of Virology, Jerome H Holland Laboratory, Rockville, MD 20855, USA
    Proc Natl Acad Sci U S A 92:4492-6. 1995
    ..We propose that regional specialization of the vertebral column has been driven by regionalization of Hox gene function and that a major aspect of this evolutionary progression may have been restriction of Hox gene expression...
  54. pmc Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene
    A C Perkins
    Walter and Eliza Hall Institute of Medical Research, Australia
    EMBO J 12:3835-46. 1993
    ..Thus ectopic expression of Hox-2.4 enhances self-renewal of immature myeloid progenitors and progression to a fully malignant state is favoured by somatic mutations conferring autocrine production of IL-3...
  55. ncbi Gene organization of murine homeobox-containing gene clusters
    M S Do
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Genomics 3:195-200. 1988
    ..Conservation of the homeo-domain and the linear gene order of homeobox-containing genes in vertebrates is discussed in light of the interactions and the anteroposterior linear order of homeotic loci in insects...
  56. pmc A mouse homeobox containing gene on chromosome 11: sequence and tissue-specific expression
    F Meijlink
    Hubrecht Laboratory, Utrecht, The Netherlands
    Nucleic Acids Res 15:6773-86. 1987
    ..3; however, major quantitative differences in this response were observed...
  57. ncbi Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain
    D G Wilkinson
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK
    Nature 341:405-9. 1989
    ..These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues...
  58. pmc Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia
    K Kongsuwan
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Nucleic Acids Res 17:1881-92. 1989
    ..4 and Hox-3.1, which reside on different chromosomes, supports the notion that an ancient homeobox gene cluster has been duplicated and dispersed early in vertebrate evolution...
  59. ncbi Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene
    A Graham
    Laboratory of Molecular Embryology, National Institute for Medical Research, London, UK
    Genes Dev 2:1424-38. 1988
    ..The patterns of Hox-2.6 expression in both mesoderm and ectoderm are spatially restricted and may reflect a role for the gene in the response to or establishment of positional cues in the embryo...
  60. ncbi The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development
    A Graham
    Division of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, UK
    Development 112:255-64. 1991
    ..This suggests that, while genes in the different murine Hox clusters may have similar A-P domains of expression, they are responding to different dorsoventral patterning signals in the developing spinal cord...
  61. ncbi A deletion and a rearrangement distinguish between the intracisternal A-particle of Hox-2.4 and that of interleukin-3 in the same leukemic cells
    L Ben-David
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Virology 182:382-7. 1991
    ..Both proviral insertions have resulted in transcriptional activation of the adjacent genes, which appears to be a significant step in the leukemogenic process in these leukemic cells...
  62. pmc The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts
    D Aberdam
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Biol 11:554-7. 1991
    ..In this study, we demonstrated the oncogenic potential of this activated homeobox gene. NIH 3T3 fibroblast clones bearing the activated Hox-2.4 gene produced fibrosarcomas in nude mice...
  63. ncbi Homeobox genes from clusters A and B demonstrate characteristics of temporal colinearity and differential restrictions in spatial expression domains in the branching mouse lung
    R Mollard
    Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Int J Dev Biol 41:655-66. 1997
    ..Such patterns of expression suggest that Hox genes play a role in the specification and maturation of lung cell lineage derivatives throughout the pseudoglandular, canalicular and terminal sac phases of lung development...
  64. pmc Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling
    Pascal te Welscher
    Department of Developmental Biology, Faculty of Biology, Utrecht University, 3584CH Utrecht, The Netherlands
    Genes Dev 16:421-6. 2002
    ..These interactions polarize the nascent limb bud mesenchyme prior to SHH signaling...
  65. pmc Cell adhesion molecules as targets for Hox genes: neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4
    F S Jones
    Laboratory of Developmental and Molecular Biology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 89:2086-90. 1992
    ..The results suggest that the N-CAM gene is likely to be a target for regulation by Hox gene products...
  66. ncbi Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes
    E van den Akker
    Hubrecht Laboratory, The Netherlands Institute for Developmental Biology, Uppsalalaan 8, Utrecht, The Netherlands
    Development 128:1911-21. 2001
    ..The phenotype of Hoxd8 loss-of-function mutants is presented, and compared with that of Hoxb8- and Hoxc8-null mice...
  67. ncbi A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations
    O Medina-Martinez
    Institute of Biosciences and Technology, Texas A and M University System Health Sciences Center, Houston 77030, USA
    Dev Biol 222:71-83. 2000
    ..Thus, Hoxb13 expression seems to be independent of the deleted region, suggesting that its expression pattern could be achieved independent of the colinear pattern of the cluster or by a regulatory element located 5' of Hoxb9...
  68. ncbi Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes
    E van den Akker
    Hubrecht Laboratory, The Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, Netherlands
    Mech Dev 89:103-14. 1999
    b>Hoxb8 mutant mice were generated by inserting the lacZ coding sequence in frame with the first exon of Hoxb8. These mice express a fusion protein with a functional beta-galactosidase activity instead of Hoxb8...
  69. ncbi Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity
    A Zuniga
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Development 126:13-21. 1999
    ..Concurrently, Gli3 functions independently of formin during initial posterior nesting of 5'HoxD domains, whereas their subsequent distal restriction and anterior expansion depends on genetic interaction of Gli3 and formin...
  70. ncbi Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice
    H Yagi
    Department of Medicine III, Osaka University Medical School, Osaka, Japan
    Blood 92:108-17. 1998
    ..These data show that the hematopoietic precursors were greatly reduced in mutant mice, and suggest that Mll functions as a regulator of the growth of hematopoietic precursors...
  71. ncbi A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton
    T Akasaka
    Immunology Branch, Center for Biomedical Science, School of Medicine, Chiba University, Japan
    Development 122:1513-22. 1996
    ....
  72. ncbi Polydactyly and ectopic ZPA formation in Alx-4 mutant mice
    S Qu
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Development 124:3999-4008. 1997
    ..expression of other candidate regulators of anterior-posterior positional information in the limb bud, including HoxB8 and Gli3, is not altered in Alx-4 mutant embryos...
  73. ncbi Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects
    Y Takihara
    Department of Medical Genetics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Development 124:3673-82. 1997
    ..These results indicate that the rae28 gene is involved in the regulation of Hox gene expression and segment specification during paraxial mesoderm and neural crest development...
  74. ncbi Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation
    K E McGrath
    Department of Pediatrics, University of Rochester Medical Center, NY 14642, USA
    Mol Reprod Dev 48:145-53. 1997
    ..We hypothesize the early expression of insulin in the YS is required for the expansion of insulin responsive cells including primitive erythroblasts...
  75. ncbi Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
    D Buscher
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Germany
    Mech Dev 62:175-82. 1997
    ..This data suggest that Gli3 is a regulator of Shh expression in mouse limb development...
  76. ncbi Hoxb-8 gain-of-function transgenic mice exhibit alterations in the peripheral nervous system
    M L Fanarraga
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
    J Neurosci Methods 71:11-8. 1997
    ....
  77. ncbi Mammalian homeobox B6 expression can be correlated with erythropoietin production sites and erythropoiesis during development, but not with hematopoietic or nonhematopoietic stem cell populations
    F Zimmermann
    Department of Transfusion Medicine, University of Ulm, Germany
    Blood 89:2723-35. 1997
    ..The results indicate that HOX B6 is intimately involved in the regulation of the erythropoietic system and could be a marker for this lineage...
  78. ncbi Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity
    D C Chan
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    Development 121:1971-8. 1995
    ..We suggest that the 1st gene product is involved in anteroposterior axis formation during normal limb development...
  79. ncbi Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice
    G L Masinde
    Molecular Genetics Division, Musculoskeletal Disease Center, J L Pettis VA Medical Center and Loma Linda University, Loma Linda, CA 92357, USA
    Bone 32:554-60. 2003
    ....
  80. doi All-trans retinoic acid-induced ectopic limb and caudal structures: murine strain sensitivities and pathogenesis
    Xiaoyan Liao
    Department of Environmental Health Sciences, University of California, Los Angeles, California 90095, USA
    Dev Dyn 237:1553-64. 2008
    ..limbs were hindlimbs (expressing Pitx1 and Tbx4 but not Tbx5), yet they also expressed the predominantly forelimb Hoxb8. Ectopic body axis formation was indicated by gene expression for ectopic primitive streaks, notochords, and nodes,..
  81. ncbi Regulation of the Hoxb-8 gene: synergism between multimerized cis-acting elements increases responsiveness to positional information
    J Charite
    Hubrecht Laboratory, The Netherlands Institute for Developmental Biology, Utrecht
    Dev Biol 171:294-305. 1995
    ..This factor is thus very likely to be involved in the transduction of positional signals...
  82. ncbi Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons
    C P Hart
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Genomics 1:182-95. 1987
    ....
  83. ncbi A distinct Hox code for the branchial region of the vertebrate head
    P Hunt
    MRC Laboratory of Eukaryotic Molecular Genetics, NIMR, Mill Hill, London, UK
    Nature 353:861-4. 1991
    ....