Hoxb13

Summary

Gene Symbol: Hoxb13
Description: homeobox B13
Alias: homeo box B13, homeobox protein Hox-B13
Species: mouse

Top Publications

  1. pmc Wnt signaling though beta-catenin is required for prostate lineage specification
    Brian W Simons
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 371:246-55. 2012
  2. ncbi HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development
    Laszlo G Komuves
    Department of Dermatology, VA Medical Center and University of California, San Francisco, California, USA
    Dev Dyn 227:192-202. 2003
  3. ncbi A molecular pathogenesis for transcription factor associated poly-alanine tract expansions
    Andrea N Albrecht
    Max Planck Institute for Molecular Genetics, Charite, Berlin, Germany
    Hum Mol Genet 13:2351-9. 2004
  4. ncbi Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction
    Thomas M Williams
    Department of Human Genetics, University of Michigan, Med Sci II 4811, Ann Arbor, MI 48109 0618, USA
    Dev Biol 277:457-71. 2005
  5. pmc Hoxb13 regulatory elements mediate transgene expression during prostate organogenesis and carcinogenesis
    Ryan P McMullin
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA
    Dev Dyn 238:664-72. 2009
  6. pmc Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
    Elena Ezhkova
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 136:1122-35. 2009
  7. pmc Persistent inflammation and angiogenesis during wound healing in K14-directed Hoxb13 transgenic mice
    Judith A Mack
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Invest Dermatol 130:856-65. 2010
  8. doi Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos
    Teddy Young
    Hubrecht Institute KNAW and University Medical Center, 3584 CT Utrecht, The Netherlands
    Dev Cell 17:516-26. 2009
  9. pmc A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland
    Ryan P McMullin
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Proc Natl Acad Sci U S A 107:98-103. 2010
  10. doi Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone
    Cesca van de Ven
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Utrecht, The Netherlands
    Development 138:3451-62. 2011

Research Grants

  1. Hoxb13 in Skin Renewal and Repair
    Judith Mack; Fiscal Year: 2008

Scientific Experts

  • Judith A Mack
  • C Landgren
  • Ryan P McMullin
  • Cesca van de Ven
  • Teddy Young
  • Kyriakos D Economides
  • Brian W Simons
  • Jean Noel Freund
  • Ana Novoa
  • Monika Bialecka
  • Jacqueline Deschamps
  • Moises Mallo
  • Felix Beck
  • Charles J Bieberich
  • Laura N Mutton
  • Elena Ezhkova
  • Thomas M Williams
  • Andrea N Albrecht
  • Marie C Hogan
  • Laszlo G Komuves
  • Mario R Capecchi
  • Paula J Hurley
  • Luigi Marchionni
  • Zhenhua Huang
  • A C Chung
  • Ashley E Ross
  • Rebecca Miller
  • Edward M Schaeffer
  • M R Carlson
  • David M Berman
  • Jennifer E Rowland
  • Frits Meijlink
  • Carina van Rooijen
  • Emma J Stringer
  • Roel Neijts
  • K Kohda
  • Cooduvalli S Shashikant
  • Andras Orosz
  • Albert Dobi
  • O Medina-Martinez
  • Shilpi Maheshwari
  • H Amalia Pasolli
  • I Hsin Su
  • Nicole Stokes
  • Jennifer Elizabeth Rowland
  • Gregory Hannon
  • Marta Carapuco
  • Johan van Nes
  • Elaine Fuchs
  • Wim de Graaff
  • Joel S Parker
  • Alexander Tarakhovsky
  • Isabelle Duluc
  • Jeffrey W Innis
  • Melissa E Williams
  • K Tanaka
  • Erich E Wanker
  • M Kasahara
  • Rudi Lurz
  • Peter N Robinson
  • Stefan Mundlos
  • Sigmar Stricker
  • T Ishibashi
  • Asita C Stiege
  • Kathrin Süring
  • Uwe Kornak
  • E Kandil
  • Annett Böddrich
  • W F Shen
  • Eric Stelnicki
  • Matthew D Griffin
  • Xiao Kui Ma
  • Christopher J Ward
  • Yuko Oda
  • Corey Largman
  • Sophia Rozenfeld
  • Lori Zeltser
  • Vicente E Torres
  • Peter C Harris
  • Sandro Rossetti
  • L Zeltser
  • S V Bryant
  • K J Jackson
  • D Katz
  • A J Cooney
  • Y Komine
  • F J DeMayo
  • D M Gardiner
  • B W O'Malley
  • F A Pereira

Detail Information

Publications22

  1. pmc Wnt signaling though beta-catenin is required for prostate lineage specification
    Brian W Simons
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 371:246-55. 2012
    ..Deletion of beta-catenin in the adult prostate did not significantly affect organ homeostasis. Collectively, these data establish that beta-catenin and Wnt signaling play key roles in prostate lineage specification and bud outgrowth...
  2. ncbi HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development
    Laszlo G Komuves
    Department of Dermatology, VA Medical Center and University of California, San Francisco, California, USA
    Dev Dyn 227:192-202. 2003
    ..We initially isolated the HOXB13 gene from human fetal skin in experiments designed to identify candidate genes that regulate scarless fetal wound ..
  3. ncbi A molecular pathogenesis for transcription factor associated poly-alanine tract expansions
    Andrea N Albrecht
    Max Planck Institute for Molecular Genetics, Charite, Berlin, Germany
    Hum Mol Genet 13:2351-9. 2004
    ..Our results provide evidence that poly-Ala repeat expansions in transcription factors result in misfolding, degradation and cytoplasmic aggregation of the mutant proteins...
  4. ncbi Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction
    Thomas M Williams
    Department of Human Genetics, University of Michigan, Med Sci II 4811, Ann Arbor, MI 48109 0618, USA
    Dev Biol 277:457-71. 2005
    ....
  5. pmc Hoxb13 regulatory elements mediate transgene expression during prostate organogenesis and carcinogenesis
    Ryan P McMullin
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA
    Dev Dyn 238:664-72. 2009
    ..Paradoxically, known prostate-restricted cis-regulatory elements are androgen dependent. Hoxb13 expression is restricted in adults to the prostate and colon, and robust Hoxb13 expression persists after ..
  6. pmc Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
    Elena Ezhkova
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 136:1122-35. 2009
    ..They maintain their proliferative potential and globally repressing undesirable differentiation programs while selectively establishing a specific terminal differentiation program in a stepwise fashion...
  7. pmc Persistent inflammation and angiogenesis during wound healing in K14-directed Hoxb13 transgenic mice
    Judith A Mack
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Invest Dermatol 130:856-65. 2010
    ..We previously showed that loss of Hoxb13 from murine skin results in enhanced cutaneous wound healing, suggesting that Hoxb13 has a negative effect on ..
  8. doi Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos
    Teddy Young
    Hubrecht Institute KNAW and University Medical Center, 3584 CT Utrecht, The Netherlands
    Dev Cell 17:516-26. 2009
    ..Concomitant regulation of Cyp26a1 expression, restraining retinoic acid signaling away from the posterior growth zone, may likewise play a role in timing the trunk-tail transition...
  9. pmc A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland
    Ryan P McMullin
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Proc Natl Acad Sci U S A 107:98-103. 2010
    b>Hoxb13 is robustly transcribed in derivatives of posterior endoderm including the colon, rectum, and the prostate gland...
  10. doi Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone
    Cesca van de Ven
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Utrecht, The Netherlands
    Development 138:3451-62. 2011
    ..They shed a new light on the etiology of the caudal dysplasia or caudal regression range of human congenital defects...
  11. ncbi Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing
    Judith A Mack
    Department of Research, Cleveland Clinic Florida, Weston, Florida, USA
    FASEB J 17:1352-4. 2003
    ..Previous studies indicate that down-regulation of HoxB13, a member of the highly conserved family of Hox transcription factors, occurs during fetal scarless wound healing...
  12. ncbi Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae
    Kyriakos D Economides
    Howard Hughes Medical Center, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Dev Biol 256:317-30. 2003
    To address the expression and function of Hoxb13, the 5' most Hox gene in the HoxB cluster, we have generated mice with loss-of-function and beta-galactosidase reporter insertion alleles of this gene...
  13. ncbi PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes
    E Kandil
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan
    Immunogenetics 46:337-44. 1997
    ..It appears that the IFN-gamma-inducible alpha- and beta-subunits emerged by gene duplication from a gamma-subunit-like precursor...
  14. pmc AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins
    W F Shen
    Department of Medicine, University of California VA Medical Center, San Francisco 94121, USA
    Mol Cell Biol 17:6448-58. 1997
    ..DNA binding complexes formed by Meis1 with Hox proteins dissociate much more slowly than DNA complexes with Meis1 alone, suggesting that Hox proteins stabilize the interactions of Meis1 proteins with their DNA targets...
  15. ncbi Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit
    K Kohda
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan
    Immunogenetics 47:77-87. 1997
    ..These results were confirmed by fluorescent in situ hybridization analysis that localized Psmb5 to band C2 to proximal D1 of chromosome 14 and Psmb5-ps to band D of chromosome 11...
  16. ncbi The mouse chondroadherin gene: characterization and chromosomal localization
    C Landgren
    Department of Cell and Molecular Biology, Lund University, Sweden
    Genomics 47:84-91. 1998
    ..The chondroadherin gene was mapped to mouse chromosome 11, near D11Mit14, by single-strand conformation polymorphism linkage analysis...
  17. ncbi A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations
    O Medina-Martinez
    Institute of Biosciences and Technology, Texas A and M University System Health Sciences Center, Houston 77030, USA
    Dev Biol 222:71-83. 2000
    ..The mouse HoxB cluster contains 10 genes, Hoxb1 to Hoxb9 and Hoxb13, which are transcribed in the same direction...
  18. pmc Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation
    A C Chung
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 21:663-77. 2001
    ..These results suggest that GCNF regulates a novel and critical developmental pathway involved in normal anteroposterior development...
  19. ncbi Expression of Hoxb13 and Hoxc10 in developing and regenerating Axolotl limbs and tails
    M R Carlson
    Developmental Biology Center, University of California, Irvine, California 92697, USA
    Dev Biol 229:396-406. 2001
    ..the role such genes play in appendage regeneration, we have compared the expression of two 5' Hox complex genes: Hoxb13 and Hoxc10 during development and regeneration of the body axis and the limbs of axolotls...
  20. ncbi PKHDL1, a homolog of the autosomal recessive polycystic kidney disease gene, encodes a receptor with inducible T lymphocyte expression
    Marie C Hogan
    Division of Nephrology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Hum Mol Genet 12:685-98. 2003
    ..Low level expression was detected in many primary immune cell subtypes but up-regulated specifically in T lymphocytes, following activation signals, suggesting a role in cellular immunity...
  21. ncbi Hoxb13 is required for normal differentiation and secretory function of the ventral prostate
    Kyriakos D Economides
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Development 130:2061-9. 2003
    ..In this study, the ventral prostate-specific function of Hoxb13 is described...
  22. ncbi Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity
    L Zeltser
    Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA
    Development 122:2475-84. 1996
    ..Because of its separation from the complex, Hoxb-13 may provide an important system to dissect the mechanism(s) responsible for the maintenance of colinearity...

Research Grants1

  1. Hoxb13 in Skin Renewal and Repair
    Judith Mack; Fiscal Year: 2008
    ..a position as a Project Scientist at the Cleveland Clinic Florida to study the role of the transcription factor Hoxb13 in cutaneous wound healing using a Hoxb13 knock out (KO) mouse line...