Hoxa5

Summary

Gene Symbol: Hoxa5
Description: homeobox A5
Alias: Hox-1.3, homeobox protein Hox-A5, homeo box A5, homeobox protein Hox-1.3, homeobox protein M2
Species: mouse

Top Publications

  1. ncbi The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein
    W F Odenwald
    Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20892
    Genes Dev 3:158-72. 1989
  2. ncbi Genetic architecture of the mouse hippocampus: identification of gene loci with selective regional effects
    J L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Monroe Avenue, Memphis, Tennessee 38163, USA
    Genes Brain Behav 2:238-52. 2003
  3. ncbi Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation
    J Carlos Villaescusa
    Department of Cell Biology and Functional Genomics, DIBIT, H San Raffaele, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Gene 330:1-7. 2004
  4. ncbi Increased DNA methylation in the HoxA5 promoter region correlates with decreased expression of the gene during tumor promotion
    Rebecca E Watson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Mol Carcinog 41:54-66. 2004
  5. pmc Impact of the loss of Hoxa5 function on lung alveogenesis
    Isabel Mandeville
    Centre de recherche de L Hôtel Dieu de Québec, 9, rue McMahon, Quebec, QC, Canada, G1R 2J6
    Am J Pathol 169:1312-27. 2006
  6. ncbi The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression
    N M van der Lugt
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Mech Dev 58:153-64. 1996
  7. ncbi The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene
    J J Zhao
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029 6574
    Genes Dev 7:343-54. 1993
  8. ncbi Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice
    Dominique Meunier
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, Canada
    Dev Dyn 227:367-78. 2003
  9. ncbi Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column
    D Kostic
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Mech Dev 46:231-47. 1994
  10. ncbi Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects
    J Aubin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Canada
    Dev Biol 192:432-45. 1997

Research Grants

Scientific Experts

  • R Kinkead
  • R Mollard
  • J E Pitera
  • MaryAnn Vitoria Volpe
  • Lucie Jeannotte
  • Bradley E Bernstein
  • A K Voss
  • C Kim
  • Josée Aubin
  • Félix Antoine Bérubé-Simard
  • Margot Lemieux
  • Polyxeni Philippidou
  • Olivier Boucherat
  • Gaëlle Gendronneau
  • Milan Joksimovic
  • Jeremy S Dasen
  • Ileana Cuevas
  • Christopher K Tuggle
  • Deneen M Wellik
  • Daniel C McIntyre
  • J Aubin
  • Yan Coulombe
  • Sébastien Tabariès
  • Roel Neijts
  • Laura Tomás-Roca
  • Benoit Lizen
  • Dimitris Karamitros
  • Siew Fen Lisa Wong
  • Filippo M Rijli
  • Youngwook Ahn
  • Steven M Hrycaj
  • Thomas di Meglio
  • Julie LaCombe
  • Ben Xu
  • Jacqueline Deschamps
  • Matthew A Abbott
  • Bennett G Novitch
  • Zicong Li
  • Elena Palmesino
  • Snezana Kojic
  • Teddy Young
  • Yiqian Zhu
  • Hye Yeong Ha
  • Nancy J Boudreau
  • Gemma Arderiu
  • Mario R Capecchi
  • Sen Wu
  • Elisabeth Garin
  • Se Young Kim
  • Rémi Terranova
  • Julie Moreau
  • Isabel Mandeville
  • Yoko Mizutani-Koseki
  • Kyo ichi Isono
  • Sarah Ivins
  • Haruhiko Koseki
  • Kyoichi Isono
  • Terry Magnuson
  • Karin E Krieger
  • Rebecca E Watson
  • J Carlos Villaescusa
  • C Larochelle
  • J L Peirce
  • Alon Y Hershko
  • Carina van Rooijen
  • Rubén Corral-San-Miguel
  • Dominique Meunier
  • Faustino Marin
  • Pilar Aroca
  • Shilu Amin
  • Luis Puelles
  • Vladimir Benes
  • Zoi Lygerou
  • Nicolas Denans
  • Alexandre J Potocnik
  • Hans Layman
  • Vikram Agarwal
  • Olivier Pourquie
  • Matthew G Schwartz
  • Nancy Boudreau
  • Tomi Bähr-Ivacevic
  • Panoraia Kotantaki
  • Alexandra L Patmanidi
  • Lisa Coussens
  • Francoise Gofflot
  • Edwina McGlinn
  • David P Bartel
  • Melissa Claus
  • Jennifer H Mansfield
  • Dimitris Kioussis

Detail Information

Publications89

  1. ncbi The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein
    W F Odenwald
    Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20892
    Genes Dev 3:158-72. 1989
    ..Overlap among DNA-binding sites suggests that regulation imparted by certain cis-elements may be integrated by these different factors...
  2. ncbi Genetic architecture of the mouse hippocampus: identification of gene loci with selective regional effects
    J L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Monroe Avenue, Memphis, Tennessee 38163, USA
    Genes Brain Behav 2:238-52. 2003
    ..Using WebQTL's extensive database of published BXD phenotypes, we also detected a strong and potentially biologically meaningful correlation between hippocampal volume and the acoustic startle response...
  3. ncbi Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation
    J Carlos Villaescusa
    Department of Cell Biology and Functional Genomics, DIBIT, H San Raffaele, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Gene 330:1-7. 2004
    ....
  4. ncbi Increased DNA methylation in the HoxA5 promoter region correlates with decreased expression of the gene during tumor promotion
    Rebecca E Watson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Mol Carcinog 41:54-66. 2004
    ..Gene array analysis identified differentially expressed genes. Expression of HoxA5, a tumor suppressor gene, was decreased following 9 wk of treatment with 27 mg CSC, and returned to control levels ..
  5. pmc Impact of the loss of Hoxa5 function on lung alveogenesis
    Isabel Mandeville
    Centre de recherche de L Hôtel Dieu de Québec, 9, rue McMahon, Quebec, QC, Canada, G1R 2J6
    Am J Pathol 169:1312-27. 2006
    ..b>Hoxa5 belongs to the Hox gene family encoding transcription factors known for their role in skeletal patterning...
  6. ncbi The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression
    N M van der Lugt
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Mech Dev 58:153-64. 1996
    ..5 onwards. We discuss the possibility that members of the murine Polycomb-group can form multimeric protein complexes of different compositions with varying affinity or specificity for different subsets of Hox genes...
  7. ncbi The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene
    J J Zhao
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029 6574
    Genes Dev 7:343-54. 1993
    ..3. The results suggest that mouse Hox-1.3 cannot only substitute functionally for Drosophila Scr in the determination of external structures but also can participate in the regulatory hierarchy of insect organogenesis...
  8. ncbi Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice
    Dominique Meunier
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, Canada
    Dev Dyn 227:367-78. 2003
    ..A phenotypical survey of the Hoxa5(-/-) mutant mice shows that the surviving mutants display symptoms of hypothyroidism, including transient growth ..
  9. ncbi Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column
    D Kostic
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Mech Dev 46:231-47. 1994
    ..The analysis of double, triple and even quadruple mutants should determine the ways in which these Hox genes interact in order to specify the multitude of tissues in a restricted region of the developing mouse embryo...
  10. ncbi Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects
    J Aubin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Canada
    Dev Biol 192:432-45. 1997
    ..Since expression of Hoxa-5 is confined to the mesenchymal component of the developing trachea and lung, the effects observed in epithelial cells may result from a disruption of normal epithelial-mesenchymal interactions...
  11. ncbi Transcriptional interferences at the Hoxa4/Hoxa5 locus: importance of correct Hoxa5 expression for the proper specification of the axial skeleton
    J Aubin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, QC, Canada
    Dev Dyn 212:141-56. 1998
    We have previously described a Hoxa5 mutant mouse line in which specification of axial identity is perturbed and viability is markedly reduced...
  12. ncbi Multiple cis-acting regulatory regions are required for restricted spatio-temporal Hoxa5 gene expression
    C Larochelle
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Canada
    Dev Dyn 214:127-40. 1999
    Genetic analyses have revealed the essential role of the murine Hoxa5 gene for the correct specification of the cervical and upper thoracic region of the skeleton, and for the normal organogenesis and function of the respiratory tract, ..
  13. ncbi Hoxa5 gene regulation: A gradient of binding activity to a brachial spinal cord element
    T Nowling
    Molecular, Cellular, and Developmental Biology Program, Iowa State University, Ames, Iowa 50011, USA
    Dev Biol 208:134-46. 1999
    ..In transgenic mice, gene fusions between Hoxa5 (previously called Hox-1...
  14. ncbi Loss of Hoxa5 gene function in mice perturbs intestinal maturation
    J Aubin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Pavillon de L Hôtel Dieu de Québec, Quebec G1R 2J6, Canada J1H 5N4
    Am J Physiol 277:C965-73. 1999
    ..One member of this family, Hoxa5, displays a dynamic pattern of expression during gut development...
  15. pmc Low level of Hox1.3 gene expression does not preclude the use of promoterless vectors to generate a targeted gene disruption. off
    L Jeannotte
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Mol Cell Biol 11:5578-85. 1991
    ....
  16. ncbi Dynamic expression of murine HOXA5 protein in the central nervous system
    Milan Joksimovic
    Interdepartmental Genetics and Department of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, IA 50011, USA
    Gene Expr Patterns 5:792-800. 2005
    ..As for other Hox genes, region-specific expression of Hoxa5 appears to be important for correct function during development...
  17. ncbi Stromal Hoxa5 function controls the growth and differentiation of mammary alveolar epithelium
    Elisabeth Garin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, Canada
    Dev Dyn 235:1858-71. 2006
    ..Several Hox genes are expressed in normal and neoplastic mammary glands. Using Hoxa5 mutant mice, we showed that Hoxa5-/- females present nursing defects...
  18. ncbi Juxtaposed Polycomb complexes co-regulate vertebral identity
    Se Young Kim
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Development 133:4957-68. 2006
    ..BMI1 complexes, along with YY1 and methylated H3-K27, were detected in upstream regulatory regions of Hoxc8 and Hoxa5. The combined data suggest a model wherein epigenetic and genetic elements cooperatively recruit and retain ..
  19. ncbi Hox patterning of the vertebrate rib cage
    Daniel C McIntyre
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical Center, 109 Zina Pitcher, Ann Arbor, MI 48109 2200, USA
    Development 134:2981-9. 2007
    ..Thus, the ;Hox code' in somitic mesoderm is the result of the distinct, graded effects of two or more Hox paralogous groups functioning in any anteroposterior location...
  20. pmc Multiple promoters and alternative splicing: Hoxa5 transcriptional complexity in the mouse embryo
    Yan Coulombe
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, Quebec, Canada
    PLoS ONE 5:e10600. 2010
    ..Multiple overlapping transcriptional units exist at the Hoxa5 locus reflecting the complexity of Hox clustering: a major form of 1...
  21. pmc The loss of Hoxa5 function causes estrous acyclicity and ovarian epithelial inclusion cysts
    Gaëlle Gendronneau
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, 9, rue McMahon, Quebec, Quebec, Canada
    Endocrinology 153:1484-97. 2012
    ..In the present study, we reported that in adult mice, the Hoxa5 gene shows a dynamic expression profile in the ovary that depends on the estrous cycle, the gestational status, ..
  22. pmc Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis
    Olivier Boucherat
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 304:L817-30. 2013
    ..A subset of Hox genes are expressed in the developing lung. Except for Hoxa5, the lack of overt lung phenotype in single mutants suggests that Hox genes may not play a predominant role in ..
  23. ncbi Expression of a homeo domain protein in noncontact-inhibited cultured cells and postmitotic neurons
    W F Odenwald
    Laboratory of Molecular Genetics, NINCDS, Bethesda, Maryland 20892
    Genes Dev 1:482-96. 1987
    ..This complex pattern of expression suggests that Hox 1.3 may provide a function required by many cell types in addition to any role it may have in morphogenesis...
  24. pmc Specific expression of the Hox 1.3 homeo box gene in murine embryonic structures originating from or induced by the mesoderm
    C Dony
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, FRG
    EMBO J 6:2965-75. 1987
    ..These data suggest a role of Hox 1.3 gene in the generation of tissues derived from or induced by the embryonal mesoderm...
  25. ncbi Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene
    L Jeannotte
    Department of Genetics and Development, Columbia University, New York, New York 10032
    Genes Dev 7:2085-96. 1993
    ..These results demonstrate that the Hoxa-5 gene has an important role in the establishment of the skeleton during development and contributes to the process whereby the axial structures are determined...
  26. ncbi Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network
    S J Gaunt
    Department of Cell and Structural Biology, University of Manchester, UK
    Development 109:329-39. 1990
    ..4 expression within the spinal cord and the testis are very similar to those shown by a neighbouring Hox-3 gene (Hox-3.3), but they are quite different from those shown by Hox-1 genes (Hox-1.2, -1.3 and -1.4)...
  27. ncbi Comparative analysis of Hoxa5 allelic series
    Sébastien Tabariès
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, Canada
    Genesis 45:218-28. 2007
    Analysis of the Hoxa5(-/-) mutants has revealed the critical role of Hoxa5 in survival, specification of axial identity, and ontogeny of organs, including the respiratory tract...
  28. ncbi Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling
    Josée Aubin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Canada
    Development 129:4075-87. 2002
    ..We have examined the role of Hox genes in gut patterning using the Hoxa5(-/-) mice as a model. Hoxa5 is expressed in a dynamic fashion in the mesenchymal component of the developing gut...
  29. pmc Influence of Hoxa5 on p53 tumorigenic outcome in mice
    Gaëlle Gendronneau
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, Canada G1R 2J6
    Am J Pathol 176:995-1005. 2010
    ..It has been suggested that HOXA5 possesses growth-suppressive properties through activation of p53 expression in human breast tissue...
  30. doi Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology
    Roel Neijts
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, and UMC Utrecht
    Dev Biol . 2016
    ..Subsequently to initial Wnt-induced activation of 3' Hox genes, Cdx transcription factors would act as crucial effectors for activating central Hox genes, until the last gene of the cluster arrests the process...
  31. ncbi Genomic maps and comparative analysis of histone modifications in human and mouse
    Bradley E Bernstein
    Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Cell 120:169-81. 2005
    ..This suggests that the DNA elements that direct the methylation represent only a small fraction of the region or lie at some distance from the site...
  32. ncbi Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development
    D J Wolgemuth
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Nature 337:464-7. 1989
    ..This overexpression correlated with changes in the normal developmental program of the gut, resulting in an inherited abnormal phenotype known as megacolon...
  33. pmc Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex
    A Baron
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    EMBO J 6:2977-86. 1987
    ..6 transcripts were present both in embryonic total RNA and in embryonal carcinoma cell cytoplasmic RNA. These various transcripts are probably generated by an alternative splicing mechanism and may thus encode a set of related proteins...
  34. pmc A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus
    D Duboule
    EMBO J 5:1973-80. 1986
    ..Hox1-3 is shown to be a member of a cluster of at least four homeo-boxes lying within a 75-kb segment of DNA on mouse chromosome 6. The structure of the whole cluster, the Hox-1 locus is presented...
  35. pmc Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons
    Thomas di Meglio
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Science 339:204-7. 2013
    ..Thus, Ezh2-dependent epigenetic regulation of intrinsic and extrinsic transcriptional programs controls topographic neuronal guidance and connectivity in the cortico-ponto-cerebellar pathway...
  36. pmc Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons
    Julie LaCombe
    Smilow Neuroscience Program, Department of Physiology and Neuroscience, Howard Hughes Medical Institute, NYU School of Medicine, New York, New York, USA
    PLoS Genet 9:e1003184. 2013
    ....
  37. pmc Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb
    Ben Xu
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor, MI 48109
    Proc Natl Acad Sci U S A 110:19438-43. 2013
    ..Deletion of all three Hox5 genes (Hoxa5, Hoxb5, and Hoxc5) leads to anterior forelimb defects resulting from derepression of Shh expression...
  38. doi Perinatal induction of Cre recombination with tamoxifen
    Benoit Lizen
    Institut des Sciences de la Vie, Universite Catholique de Louvain, 1348, Louvain la Neuve, Belgium
    Transgenic Res 24:1065-77. 2015
    ..They were also validated with the Hoxa5 conditional allele...
  39. pmc Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs
    Siew Fen Lisa Wong
    EMBL Australia, Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia
    Proc Natl Acad Sci U S A 112:E4884-93. 2015
    ..By feeding into, and thereby integrating, multiple genetic networks controlling vertebral number and identity, miR-196 is a critical player defining axial formulae. ..
  40. doi Hoxa5/Cre transgenic mice: novel tools for regional deletion along the anterior-posterior axis
    Félix Antoine Bérubé-Simard
    Department of Molecular Biology, Medical Biochemistry and Pathology, Universite Laval, Quebec, Canada Centre de recherche sur le cancer de l Université Laval, Centre de Recherche du Centre Hospitalier Universitaire de Québec, L Hôtel Dieu de Québec, Quebec, Canada
    Genesis 52:149-56. 2014
    The Hoxa5 homeobox gene encodes a transcription factor that plays a critical role in specifying the identity of the cervico-thoracic region along the anterior-posterior embryo axis and in orchestrating organ morphogenesis...
  41. pmc Sustained endothelial expression of HoxA5 in vivo impairs pathological angiogenesis and tumor progression
    Ileana Cuevas
    Department of Surgery, Surgical Research Laboratory, University of California, San Francisco, San Francisco, California, United States of America
    PLoS ONE 10:e0121720. 2015
    b>HoxA5 is expressed in quiescent endothelial cells (EC), but absent in activated angiogenic EC...
  42. doi Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development
    Youngwook Ahn
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Dev Biol 388:134-44. 2014
    ..Our data demonstrate that multiple RAREs cooperate to remotely regulate 5׳ Hoxb genes during CNS development, providing a new insight into the mechanisms for gene regulation within the Hox clusters...
  43. doi Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors
    Dimitris Karamitros
    Department of Physiology, Medical School, University of Patras, Rio, Patras 26504, Greece
    Development 142:70-81. 2015
    ..Our data suggest that geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system. ..
  44. pmc YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis
    Félix Antoine Bérubé-Simard
    Department of Molecular Biology, Medical Biochemistry and Pathology, Universite Laval, Quebec, Canada Centre de recherche sur le cancer de l Université Laval, Quebec, Canada Centre de recherche du Centre Hospitalier Universitaire de Québec, L Hôtel Dieu de Québec, Quebec, Canada
    PLoS ONE 9:e93989. 2014
    ..The Hoxa5 gene plays a crucial role in lung and gut organogenesis...
  45. doi Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features
    Laura Tomás-Roca
    Department of Human Anatomy and Psychobiology, School of Medicine, University of Murcia, and IMIB Instituto Murciano de Investigación Biosanitaria, 30100, Murcia, Spain
    Brain Struct Funct 221:815-38. 2016
    ..Additionally, our analysis identified an internal molecular organization of the migrated pontine nuclei that reflects a differential segmental origin of their neurons as assessed by Hox gene expression. ..
  46. pmc Sustained Hox5 gene activity is required for respiratory motor neuron development
    Polyxeni Philippidou
    Howard Hughes Medical Institute, New York University School of Medicine, Smilow Neuroscience Program, Department of Physiology and Neuroscience, New York, New York, USA
    Nat Neurosci 15:1636-44. 2012
    ..We show that two Hox genes, Hoxa5 and Hoxc5, control diverse aspects of PMC development including their clustering, intramuscular branching, and ..
  47. pmc Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes
    Kyo ichi Isono
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Tsurumi ku, Yokohama 230 0045, Japan
    Mol Cell Biol 25:6694-706. 2005
    ..Functional redundancy between Phc2 and Phc1 leads us to hypothesize that the overall level of polyhomeotic orthologues in nuclei is a parameter that is critical in enabling the class II PcG complexes to exert their molecular functions...
  48. pmc Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll
    Rémi Terranova
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 103:6629-34. 2006
    ..These observations provide previously undescribed evidence for the in vivo relationship and SET domain dependence between histone methylation and DNA methylation on MLL target genes during embryonic development...
  49. ncbi Toward simpler and faster genome-wide mutagenesis in mice
    Sen Wu
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Nat Genet 39:922-30. 2007
    ....
  50. doi Morphogenetic lung defects of JSAP1-deficient embryos proceeds via the disruptions of the normal expressions of cytoskeletal and chaperone proteins
    Hye Yeong Ha
    Division of Nano Sciences and Brain Disease Research Institute, Ewha Womans University, Seoul, Republic of Korea
    Proteomics 8:1071-80. 2008
    ....
  51. pmc HoxA5 stabilizes adherens junctions via increased Akt1
    Gemma Arderiu
    Department of Surgery, University of California San Francisco, San Francisco, California 94143, USA
    Cell Adh Migr 1:185-95. 2007
    ..Whereas HoxA5 is down regulated in active angiogenic endothelial cells (EC), sustained expression of HoxA5 induces TSP-2 and ..
  52. pmc Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain
    Yiqian Zhu
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    J Neuropathol Exp Neurol 68:626-32. 2009
    ..We previously showed that the transcription factor homeobox A5 (HoxA5), which is absent in activated angiogenic endothelial cells can block angiogenesis...
  53. doi Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos
    Teddy Young
    Hubrecht Institute KNAW and University Medical Center, 3584 CT Utrecht, The Netherlands
    Dev Cell 17:516-26. 2009
    ..Concomitant regulation of Cyp26a1 expression, restraining retinoic acid signaling away from the posterior growth zone, may likewise play a role in timing the trunk-tail transition...
  54. doi Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity
    Anne K Voss
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Dev Cell 17:674-86. 2009
    ..In conclusion, our data show that Moz regulates H3K9 acetylation at Hox gene loci and that RA can act independently of Moz to establish specific Hox gene expression boundaries...
  55. ncbi Clustered homeo boxes are differentially expressed during murine development
    A M Colberg-Poley
    Cell 43:39-45. 1985
    ..Finally, we have described the differential expression of these homeo-box-containing regions in various adult tissues...
  56. doi A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein
    Snezana Kojic
    Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11010 Belgrade, Serbia
    Arch Biochem Biophys 502:60-7. 2010
    ..It is probable that Ankrd1/CARP has a role in the propagation of signals initiated by myogenic regulatory factors (MRFs) during myogenesis...
  57. pmc Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling
    Elena Palmesino
    Neural Circuit Development Laboratory, Institut de Recherches Cliniques de Montreal, Montreal, Canada
    PLoS Biol 8:e1000446. 2010
    ..Together, these observations point to identical transcription factors that control motor axon guidance and soma migration and reveal the molecular hierarchy of myotopic organisation...
  58. pmc Transgenic over-expression of growth differentiation factor 11 propeptide in skeleton results in transformation of the seventh cervical vertebra into a thoracic vertebra
    Zicong Li
    Department of Human Nutrition, Food and Animal Sciences, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Mol Reprod Dev 77:990-7. 2010
    ..These results demonstrated significant effects of GDF11 propeptide transgene on vertebral formation, which are likely occurring through depressing GDF11 function and altered locations of Hoxa-4 and Hoxa-5 expression...
  59. pmc Hox-1.11 and Hox-4.9 homeobox genes
    A Nazarali
    Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:2883-7. 1992
    ..3 and Hox-4.2 genomic DNA revealed some differences in nucleotide sequences and in the deduced homeodomain amino acid sequences compared with the sequences that have been reported...
  60. ncbi Stage-specific homeotic vertebral transformations in mouse fetuses induced by maternal hyperthermia during somitogenesis
    Z L Li
    Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Japan
    Dev Dyn 216:336-48. 1999
    ....
  61. ncbi Identification and promoter activity of DNase I hypersensitive sites in the region of the Hox-1.3 gene
    C G Lobe
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    DNA Cell Biol 13:149-60. 1994
    ....
  62. ncbi Organization and expression of mouse Hox3 cluster genes
    J Goto
    Department of Biochemistry, School of Medicine, University of Tokyo, Japan
    Mol Gen Genet 239:41-8. 1993
    ..6 and Hox3.5 during embryogenesis revealed that the relationship between relative position in the Hox3 cluster and expression domain along antero-posterior axis appears similar to that seen for members of the other Hox clusters...
  63. ncbi GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function
    P Godfrey
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208
    Nat Genet 4:227-32. 1993
    ..Similar alterations in GHRHR might explain some isolated GH deficiencies in humans...
  64. ncbi The short 3'-end region of complementary DNAs as PCR-based polymorphic markers for an expression map of the mouse genome
    N Takahashi
    Furusawa MorphoGene Project, ERATO, Research Development Corporation of Japan JRDC, Tsukuba
    Genomics 16:161-8. 1993
    ....
  65. ncbi A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton
    T Akasaka
    Immunology Branch, Center for Biomedical Science, School of Medicine, Chiba University, Japan
    Development 122:1513-22. 1996
    ....
  66. pmc Functional dissection of the mouse Hox-a5 gene
    J J Zhao
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    EMBO J 15:1313-22. 1996
    ..Our results suggest that this type of protein-protein interaction may be essential for the biological activities of Hox-a5 and Scr...
  67. ncbi Orientation of the Hoxa complex and placement of the Hd locus distal to Hoxa2 on mouse chromosome 6
    J W Innis
    Department of Human Genetics, Med Sci II, Ann Arbor, Michigan 48109 0618, USA
    Mamm Genome 7:216-7. 1996
  68. ncbi Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice
    N Core
    Centre d Immunologie INSERM CNRS de Marseille Luminy, France
    Development 124:721-9. 1997
    ..5, leading to the hypothesis that, during development, the M33 gene might play a role in defining access to retinoic acid response elements localised in the regulatory regions of several Hox genes...
  69. ncbi Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects
    Y Takihara
    Department of Medical Genetics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Development 124:3673-82. 1997
    ..These results indicate that the rae28 gene is involved in the regulation of Hox gene expression and segment specification during paraxial mesoderm and neural crest development...
  70. ncbi Homeobox genes from clusters A and B demonstrate characteristics of temporal colinearity and differential restrictions in spatial expression domains in the branching mouse lung
    R Mollard
    Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Int J Dev Biol 41:655-66. 1997
    ..Such patterns of expression suggest that Hox genes play a role in the specification and maturation of lung cell lineage derivatives throughout the pseudoglandular, canalicular and terminal sac phases of lung development...
  71. ncbi A duplicated zone of polarizing activity in polydactylous mouse mutants
    H Masuya
    Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Japan
    Genes Dev 9:1645-53. 1995
    ..All results indicate the presence of an additional ZPA at the anterior margin of limb buds in these mutants. Thus, it appears that multiple endogenous genes regulate the spatial localization of the ZPA in the developing mouse limb bud...
  72. ncbi Activation of Hox gene expression by Hoxa-5
    C G Lobe
    Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
    DNA Cell Biol 14:817-23. 1995
    ....
  73. ncbi Coding sequence and expression of the homeobox gene Hox 1.3
    M Fibi
    Max Planck Institut fur biophysikalische Chemie, Gottingen, FRG
    Development 102:349-59. 1988
    ..Untransformed 3T3 cells carry abundant 1.9 kb Hox 1.3 RNA, whereas the methylcholanthrene-transformed MB66 and LTK- cells or 3T3 cells transformed by the oncogenes src, fos or SV40 T antigen express only low levels...
  74. ncbi Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code
    J E Pitera
    Gastroenterology Unit, Institute of Child Health, University College London, London, England
    Gastroenterology 117:1339-51. 1999
    ..We have studied the expression domains of these genes in the gut both spatially and temporally...
  75. ncbi Ectopic HOXA5 expression results in abnormal differentiation, migration and p53-independent cell death of superficial dorsal horn neurons
    Matthew A Abbott
    Interdepartmental Genetics, Iowa State University, Ames, IA 50011, USA
    Brain Res Dev Brain Res 159:87-97. 2005
    Previously, we reported a line of mice (Hoxa5SV2) that ectopically expresses HOXA5 in the developing cervical and brachial dorsal spinal cord...
  76. ncbi Cooperation of Hoxa5 and Pax1 genes during formation of the pectoral girdle
    Josée Aubin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, G1R 2J6, Canada
    Dev Biol 244:96-113. 2002
    ..Some skeletal malformations encountered in Hoxa5 mutants are shared by the undulated (un) mice, which bear a point mutation in the Pax1 gene...
  77. ncbi Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors
    Isabelle Foucher
    CNRS UMR 8542, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 129:4065-74. 2002
    Transgenic mice expressing the homeobox gene Hoxa5 under the control of Hoxb2 regulatory elements present a growth arrest during weeks two and three of postnatal development, resulting in proportionate dwarfism...
  78. ncbi The mouse PcG gene eed is required for Hox gene repression and extraembryonic development
    Jianbo Wang
    Department of Genetics, CB 7264, The University of North Carolina, Chapel Hill 27599 7264, USA
    Mamm Genome 13:493-503. 2002
    ..However, genetic crosses with a Mash2 null allele suggested that Eed was not required to maintain Mash2 imprinting, but could be required in a lineage specific fashion to suppress Mash2 expression...
  79. pmc Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster
    I Pellerin
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway
    Mol Cell Biol 14:4532-45. 1994
    ..In this study, we characterized the DNA binding properties of five representative members of the Hox family: HoxA5, HoxB4, HoxA7, HoxC8, and HoxB1...
  80. ncbi Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development
    Alon Y Hershko
    Department of Cellular Biochemistry and Human Genetics, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Gene 302:65-72. 2003
    ..Here we describe the methylation patterns of HoxA5 and HoxB5 in various tissues of fetal and adult mice and their relevance to expression...
  81. pmc Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
    Kyoichi Isono
    Developmental Genetics Group, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama 230 0045, Japan
    Genes Dev 19:536-41. 2005
    ..Importantly, the levels of Sf3b1 in PcG complexes were decreased in Sf3b1-heterozygous embryos. These findings suggest that Sf3b1-PcG protein interaction is essential for true PcG-mediated repression of Hox genes...
  82. ncbi Respiratory adaptations to lung morphological defects in adult mice lacking Hoxa5 gene function
    Richard Kinkead
    Departement de Pediatrie, Centre Hospitalier Universitaire de Quebec, Centre de recherche de l Hôpital St François d Assise, Quebec, Canada, G1L 3L5
    Pediatr Res 56:553-62. 2004
    The Hoxa5 mutation is associated with a high perinatal mortality rate caused by a severe obstruction of the laryngotracheal airways, pulmonary dysmorphogenesis, and a decreased production of surfactant proteins...
  83. pmc Unique spatial and cellular expression patterns of Hoxa5, Hoxb4, and Hoxb6 proteins in normal developing murine lung are modified in pulmonary hypoplasia
    MaryAnn Vitoria Volpe
    Div of Newborn Medicine, Department of Pediatrics, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Birth Defects Res A Clin Mol Teratol 82:571-84. 2008
    ..Our objective was to determine how pulmonary hypoplasia alters temporal, spatial, and cellular expression of Hoxa5, Hoxb4, and Hoxb6 proteins compared to normal lung development.
  84. ncbi Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1
    Sarah Ivins
    Molecular Medicine Unit, Institute of Child Health, London WC1N 1EH, UK
    Dev Biol 285:554-69. 2005
    ..These experiments highlight which genes and pathways potentially affected by lack of Tbx1, and whose role may be explored further by testing for epistasis using mouse mutants...
  85. ncbi Transgenic mice ectopically expressing HOXA5 in the dorsal spinal cord show structural defects of the cervical spinal cord along with sensory and motor defects of the forelimb
    Karin E Krieger
    Interdepartmental Genetics, Iowa State University, Ames, IA 50011, USA
    Brain Res Dev Brain Res 150:125-39. 2004
    Mutation of murine Hoxa5 has shown that HOXA5 controls lung, gastrointestinal tract and vertebrae development. Hoxa5 is also expressed in the spinal cord, yet no central nervous system phenotype has been described in Hoxa5 knockouts...
  86. ncbi Hoxa-5 in mouse developing lung: cell-specific expression and retinoic acid regulation
    C Kim
    Division of Newborn Medicine, Floating Hospital for Children at New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Physiol Lung Cell Mol Physiol 279:L863-71. 2000
    ..Cycloheximide and actinomycin D treatment studies suggested that the differences in RA effect on each cell type may involve the presence of a repressor that can be overcome by RA...
  87. ncbi Conservation and divergence of patterns of expression and lineage-specific transcripts in orthologues and paralogues of the mouse Hox-1.4 gene
    F Watrin
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Dev Biol 156:136-45. 1993
    ..4, Hox-1.3 and Hox-1.5, are expressed in the germ line but at lower levels. Further, both Hox-1.3 and Hox-1.4 produced unique, germ line-specific transcripts as compared to other adult tissues and the Day 12.5 embryo...
  88. ncbi Region-specific gastrointestinal Hox code during murine embryonal gut development
    Yasuhiro Kawazoe
    Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, 4 24 1 Kuhonji, Kumamoto 862 0976, Japan
    Dev Growth Differ 44:77-84. 2002
    ....
  89. ncbi Identification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression
    C W Bogue
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520
    Am J Physiol 266:L448-54. 1994
    ..We conclude that there are many homeobox genes expressed in developing rodent lung and that their mRNA levels are affected by both gestational age and RA...

Research Grants1

  1. DEVELOPMENTAL MECHANISMS OF HOXA5 SPATIAL REGULATION
    Lucie Jeannotte; Fiscal Year: 2003
    ..Mesodermal structures specifically affected in Hoxa5 mutant mice develop from this spatial region; therefore such elements are central to Hox5 functional expression...