Hnf4a

Summary

Gene Symbol: Hnf4a
Description: hepatic nuclear factor 4, alpha
Alias: HNF-4, Hnf4, Hnf4alpha, MODY1, Nr2a1, TCF-14, Tcf14, hepatocyte nuclear factor 4-alpha, HNF4 alpha, Nuclear receptor 2A1, nuclear receptor subfamily 2 group A member 1, transcription factor 14, transcription factor HNF-4
Species: mouse

Top Publications

  1. pmc GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo
    E E Morrisey
    Department of Medicine, University of Chicago, Chicago, Illinois 60637 USA
    Genes Dev 12:3579-90. 1998
  2. ncbi Restriction of apolipoprotein A-IV gene expression to the intestine villus depends on a hormone-responsive element and parallels differential expression of the hepatic nuclear factor 4alpha and gamma isoforms
    Dominique Sauvaget
    U505 INSERM, Universite Pierre et Marie Curie, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 277:34540-8. 2002
  3. ncbi Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver
    Nadege Briancon
    Unité de Génétique de la Différenciation, URA 2578 du CNRS, Departement de Biologie du Developpement, Institut Pasteur, Paris Cedex 15 75724, France
    J Biol Chem 279:33398-408. 2004
  4. ncbi Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas
    Takao Nammo
    Department of Metabolic Medicine, Graduate School of Medicine, B5, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Gene Expr Patterns 8:96-106. 2008
  5. doi Hepatocyte nuclear factor 4α regulates expression of the mouse female-specific Cyp3a41 gene in the liver
    Wattanaporn Bhadhprasit
    Department of Toxicology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Drug Metab Dispos 39:490-7. 2011
  6. pmc Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis
    Yuxia Zhang
    Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Biol Chem 286:29635-43. 2011
  7. pmc Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9
    Hiroto Ohguchi
    Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153 8904, Japan
    Mol Cell Biol 28:3917-31. 2008
  8. ncbi The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
  9. pmc Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells
    Jared N Boustead
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Biochem J 369:17-22. 2003
  10. pmc Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo
    Serkan Kir
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 287:41334-41. 2012

Research Grants

  1. The role of HNF4 in gastrointestinal development
    Michele Battle; Fiscal Year: 2006
  2. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  3. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
  4. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  5. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
  6. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications124 found, 100 shown here

  1. pmc GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo
    E E Morrisey
    Department of Medicine, University of Chicago, Chicago, Illinois 60637 USA
    Genes Dev 12:3579-90. 1998
    ..endoderm and severely attenuate, or fail to express, genes encoding early and late endodermal markers, including HNF4, GATA4, alpha-fetoprotein (AFP), and HNF3beta. Homozygous GATA6(-/-) mice died between embryonic day (E) 6.5 and E7...
  2. ncbi Restriction of apolipoprotein A-IV gene expression to the intestine villus depends on a hormone-responsive element and parallels differential expression of the hepatic nuclear factor 4alpha and gamma isoforms
    Dominique Sauvaget
    U505 INSERM, Universite Pierre et Marie Curie, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 277:34540-8. 2002
    ..The in vivo observation of parallel gradients for apoA-IV and HNF-4gamma gene expression raises questions concerning whether this transcription factor plays a specific role in the control of enterocyte differentiation...
  3. ncbi Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver
    Nadege Briancon
    Unité de Génétique de la Différenciation, URA 2578 du CNRS, Departement de Biologie du Developpement, Institut Pasteur, Paris Cedex 15 75724, France
    J Biol Chem 279:33398-408. 2004
    ..We conclude that although HNF6/OC-2 and perhaps HNF1 activate the P2 promoter in the embryo, increasing HNF4alpha1 expression throughout development causes a switch to essentially exclusive P1 promoter activity in the adult liver...
  4. ncbi Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas
    Takao Nammo
    Department of Metabolic Medicine, Graduate School of Medicine, B5, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Gene Expr Patterns 8:96-106. 2008
    ..J., et al., 1996b. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 384, 458-460; Horikawa, Y., Iwasaki, N., Hara, M., Furuta, H., Hinokio, Y., Cockburn, B.N. et al., 1997...
  5. doi Hepatocyte nuclear factor 4α regulates expression of the mouse female-specific Cyp3a41 gene in the liver
    Wattanaporn Bhadhprasit
    Department of Toxicology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Drug Metab Dispos 39:490-7. 2011
    CYP3A41 is a female-specific cytochrome P450 in mouse liver. A putative hepatocyte nuclear factor 4α (HNF4α)-binding site was found at -99/-87 in the promoter of Cyp3a41 by reporter assays performed in the hepatocytes of female mice...
  6. pmc Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis
    Yuxia Zhang
    Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Biol Chem 286:29635-43. 2011
    ..Hepatocyte nuclear factor 4α (HNF4α) activated the Egr-1 promoter through three DR1 response elements as identified by trans-activation assays...
  7. pmc Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9
    Hiroto Ohguchi
    Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153 8904, Japan
    Mol Cell Biol 28:3917-31. 2008
    ..Dio1 mRNA and enzyme activity levels are markedly reduced in the livers of hepatocyte nuclear factor 4alpha (HNF4alpha)-null mice, thus accounting for its liver-specific expression...
  8. ncbi The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
    ..This network operating at the onset of liver development contains candidate genes for investigation of liver carcinogenesis...
  9. pmc Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells
    Jared N Boustead
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Biochem J 369:17-22. 2003
    ....
  10. pmc Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo
    Serkan Kir
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 287:41334-41. 2012
    ..Here, in a series of loss-of-function studies, we show that the nuclear receptors HNF4α and LRH-1 have dual roles in regulating Cyp7a1 in vivo...
  11. pmc DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression
    Balachandar Nedumaran
    Hormone Research Center, School of Biological Science and Technology, Chonnam National University, Gwangju 500 757, South Korea
    J Biol Chem 284:27511-23. 2009
    ..b>HNF4alpha (hepatocyte nuclear factor 4alpha) is a liver-enriched transcription factor that controls the expression of a ..
  12. ncbi The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB)
    Jean Francois Louet
    Institut Cochin, Departement d Endocrinologie, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    J Biol Chem 277:37991-8000. 2002
    ..that the coactivator PGC-1 is involved in the regulation of this gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB)...
  13. ncbi SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes
    Takashi Yamamoto
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Biol Chem 279:12027-35. 2004
    ..Our data indicate that SREBP-1 has a novel role as negative regulator of gluconeogenic genes through a cross-talk with HNF-4alpha interference with PGC-1 recruitment...
  14. ncbi Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha
    Ji Miao
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Biol Chem 281:14537-46. 2006
    ....
  15. pmc Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation
    Marianna Sadagurski
    Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell Biol 26:2675-87. 2006
    ..In conclusion, these results reveal that IGF-1R plays an inhibitory role in the regulation of skin development and differentiation...
  16. pmc Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development
    Jean Bernard Beaudry
    box 7529, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Mol Cell Biol 26:6037-46. 2006
    ..Our observations on the regulation of g6pc by HNF-6 provide a model whereby synergism, interdependency, and threshold concentrations of LETFs and coactivators determine time-specific expression of genes during liver development...
  17. doi A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding
    Keiko Hirota
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 283:32432-41. 2008
    ....
  18. ncbi Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis
    S Taraviras
    Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, FRG
    Mech Dev 48:67-79. 1994
    ..The complexity of the HSs suggests that multiple elements might contribute to the transcriptional regulation of the HNF-4 gene...
  19. ncbi Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos
    W S Chen
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021
    Genes Dev 8:2466-77. 1994
    ..Development of embryonic structures is severely impaired. These results demonstrate that the expression of HNF-4 in the visceral endoderm is essential for embryonic ectoderm survival and normal gastrulation...
  20. pmc Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst
    S A Duncan
    Department of Molecular Cell Biology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 91:7598-602. 1994
    ..This expression pattern suggests that HNF-4 has a role in the earliest stages of murine postimplantation development as well as in organogenesis...
  21. ncbi Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
    K Yamagata
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Nature 384:458-60. 1996
    ..Linkage studies have localized the genes that are mutated in MODY on human chromosomes 20 (MODY1), 7 (MODY2) and 12 (MODY3), with MODY2 and MODY3 being allelic with the genes encoding glucokinase, a key ..
  22. ncbi Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos
    S A Duncan
    Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021, USA
    Development 124:279-87. 1997
    ..Furthermore, specific complementation of Hnf-4(-/-) embryos with tetraploid-derived Hnf-4(+/+) VE rescues their early developmental arrest, showing conclusively that a functional VE is mandatory for gastrulation...
  23. ncbi GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
    C T Kuo
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Genes Dev 11:1048-60. 1997
    ..However, they define a critical role for GATA4 in regulating the rostral-to-caudal and lateral-to-ventral folding of the embryo that is needed for normal cardiac morphogenesis...
  24. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
    ..We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP...
  25. pmc The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
    C Sirard
    Amgen Institute, Toronto, Ontario M5G 2C1, Canada
    Genes Dev 12:107-19. 1998
    ..Rescued embryos show severe anterior truncations, indicating a second important role for Smad4 in anterior patterning during embryogenesis...
  26. pmc An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types
    H Nakhei
    Universitatsklinikum Essen, Institut für Zellbiologie Tumorforschung, Hufelandstrasse 55, D 45122 Essen, Germany
    Nucleic Acids Res 26:497-504. 1998
    The transcription factor hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue specific transcription factor mainly expressed in the liver, kidney, intestine and the endocrine pancreas, but is also an essential regulator for early ..
  27. pmc Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha
    J Li
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53211 USA
    Genes Dev 14:464-74. 2000
    ..We therefore conclude that HNF-4alpha is both essential for hepatocyte differentiation during mammalian liver development and also crucial for metabolic regulation and liver function...
  28. pmc Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
    James Rhee
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:4012-7. 2003
    ..known to bind gluconeogenic promoters including the glucocorticoid receptor, hepatocyte nuclear factor 4alpha (HNF4alpha), and the peroxisome proliferator-activated receptors...
  29. ncbi Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis
    Fereshteh Parviz
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nat Genet 34:292-6. 2003
    ..Here we report that hepatocyte nuclear factor 4alpha (Hnf4alpha) is essential for morphological and functional differentiation of hepatocytes, accumulation of hepatic glycogen ..
  30. ncbi Targeted insertion of an IRES Cre into the Hnf4alpha locus: Cre-mediated recombination in the liver, kidney, and gut epithelium
    Stephane D Vincent
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    Genesis 39:206-11. 2004
    The Hnf4alpha gene belongs to a family of trancriptional regulators required for liver development and function...
  31. ncbi Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alpha
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 302:11-21. 2005
    ....
  32. pmc The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion
    Rana K Gupta
    Department of Genetics, Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 115:1006-15. 2005
    ..Our data provide genetic evidence that HNF-4alpha is required in the pancreatic beta cell for regulation of the pathway of insulin secretion dependent on the ATP-dependent potassium channel...
  33. pmc Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha
    Yusuke Inoue
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 47:215-27. 2006
    Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates many genes that are preferentially expressed in liver...
  34. ncbi Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells
    Atsuko Miura
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:5246-57. 2006
    Mutations in the hepatocyte nuclear factor (HNF)-4alpha gene cause a form of maturity-onset diabetes of the young (MODY1) that is characterized by impairment of glucose-stimulated insulin secretion by pancreatic beta-cells...
  35. ncbi Role of hepatocyte nuclear factor 4alpha in control of blood coagulation factor gene expression
    Yusuke Inoue
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Med (Berl) 84:334-44. 2006
    Hepatocyte nuclear factor 4alpha (HNF4alpha) plays an important role in the maintenance of many liver-specific functions...
  36. ncbi Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism
    James Rhee
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    J Biol Chem 281:14683-90. 2006
    ..In the fasted liver, PGC-1alpha is induced and interacts with hepatocyte nuclear factor 4alpha (HNF4alpha) and other transcription factors to activate gluconeogenesis and increase hepatic glucose output...
  37. pmc Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon
    Wendy D Garrison
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53326, USA
    Gastroenterology 130:1207-20. 2006
    b>Hepatocyte nuclear factor 4 alpha (HNF4alpha) is a transcription factor that has been shown to be required for hepatocyte differentiation and development of the liver...
  38. pmc Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
    Michele A Battle
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
    Proc Natl Acad Sci U S A 103:8419-24. 2006
    ..Previous studies using conditional knockout mice have shown that loss of hepatocyte nuclear factor 4alpha (HNF4alpha) blocks the epithelial transformation of the fetal liver, suggesting that HNF4alpha is a central regulator of ..
  39. pmc Plasticity and expanding complexity of the hepatic transcription factor network during liver development
    Irene Kyrmizi
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, 711 10 Herakleion, Crete, Greece
    Genes Dev 20:2293-305. 2006
    ..The results illustrate the remarkable flexibility of a self-sustaining transcription factor network, built up by complex dominant and redundant regulatory motifs in developing hepatocytes...
  40. ncbi Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha
    Elyhisha A Hanniman
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Lipid Res 47:2503-14. 2006
    ..Together, these results indicate that the induction of apoA-IV expression in fasting and diabetes likely involves PGC-1 alpha-mediated coactivation of HNF-4 alpha in addition to glucocorticoid-dependent actions...
  41. pmc Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha
    Rana K Gupta
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:756-69. 2007
    ..hepatocyte nuclear factor-4alpha (HNF-4alpha), the gene that is mutated in Maturity-Onset Diabetes of the Young 1 (MODY1)...
  42. ncbi The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter
    Bikesh Dongol
    Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    J Lipid Res 48:1781-91. 2007
    ..Wy-14,643 and that Acot1 mRNA was also increased by 15-fold in the liver of hepatocyte nuclear factor 4alpha (HNF4alpha) knockout animals...
  43. ncbi Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c
    Bhaskar Ponugoti
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Mol Endocrinol 21:2698-712. 2007
    ..This mechanism may be relevant to known repression of many other HNF-4 target genes upon feeding...
  44. pmc Morphogenetic competence of HNF4 alpha-deficient mouse hepatic cells
    Graham P Hayhurst
    Unité de Génétique de la Différenciation, Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France
    J Hepatol 49:384-95. 2008
    To specify roles of HNF 4 alpha in mouse liver development, we have analyzed the ex vivo morphogenetic potential of HNF4 alpha-null embryonic hepatic cells.
  45. doi Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation
    Jean Philippe Babeu
    Département d Anatomie et de Biologie Cellulaire, Universite de Sherbrooke, Canadian Institutes of Health Research Team on Digestive Epithelium, Sherbrooke, QC J1H 5N4, Canada
    Am J Physiol Gastrointest Liver Physiol 297:G124-34. 2009
    Hepatocyte nuclear factor 4alpha (HNF4alpha) is a regulator of hepatocyte and pancreatic transcription. Hnf4alpha deletion in the mouse is embryonically lethal with severe defects in visceral endoderm formation...
  46. pmc Proteomics reveals a physical and functional link between hepatocyte nuclear factor 4alpha and transcription factor IID
    Hidehisa Takahashi
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Biol Chem 284:32405-12. 2009
    ..of a physical and functional link between the orphan nuclear receptor hepatocyte nuclear factor 4alpha (HNF4alpha) and transcription factor IID (TFIID)...
  47. pmc Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism
    Celia Pilar Martinez-Jimenez
    Biomedical Sciences Research Center Alexander Fleming, 16672 Vari, Greece
    Mol Cell Biol 30:565-77. 2010
    ..Here, we demonstrate a transcription factor network under the control of hepatocyte nuclear factor 4alpha (HNF4alpha) that coordinates the reciprocal expression of fatty acid transport and metabolizing enzymes during fasting and ..
  48. pmc Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Science 328:1036-40. 2010
    ..experimentally the genome-wide occupancy of two TFs, CCAAT/enhancer-binding protein alpha and hepatocyte nuclear factor 4 alpha, in the livers of five vertebrates...
  49. pmc Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver
    Brad G Hoffman
    Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 20:1037-51. 2010
    ..these tissues, we globally identify binding sites for FOXA2 in adult mouse islets and liver, PDX1 in islets, and HNF4A in liver...
  50. pmc Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome
    Jennifer J Hofmann
    Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Development 137:4061-72. 2010
    ..These findings uncover the cellular basis for the defining feature of AGS, identify mesenchymal Jag1-dependent and -independent stages of duct development, and provide mechanistic information for the role of Jag1 in IHBD formation...
  51. pmc Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis
    Liya Yin
    Department of Integrative Medical Sciences, Northeastern Ohio Universities College of Medicine, 4209 State Rte 44, Rootstown, OH 44272, USA
    Arterioscler Thromb Vasc Biol 31:328-36. 2011
    Loss-of-function mutations in human hepatocyte nuclear factor 4α (HNF4α) are associated with maturity-onset diabetes of the young and lipid disorders. However, the mechanisms underlying the lipid disorders are poorly understood...
  52. doi Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
    Kenichiro Furuyama
    Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Nat Genet 43:34-41. 2011
    ..These results suggest interdependence between the structure and homeostasis of endodermal organs, with Sox9 expression being linked to progenitor status...
  53. ncbi Hepatocyte nuclear factor 4 alpha is associated with mesenchymal-epithelial transition in developing kidneys of C57BL/6 mice
    Tomonori Kanazawa
    Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 73:601-7. 2011
    ..We have previously reported that knock-down of the expression of hepatocyte nuclear factor 4 alpha (Hnf4a) gene induces failure of cellular organization in the condensed mesenchyme (CM) of cultured ..
  54. pmc Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice
    Jessica A Bonzo
    Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:7345-56. 2012
    ..The hepatocyte-specific Hnf4a knock-out mouse develops severe hepatomegaly and steatosis resulting in premature death, thereby limiting studies ..
  55. pmc Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα
    Huma Safdar
    Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e38104. 2012
    Hepatocyte nuclear factor 4α (HNF4α) and CCAAT/enhancer-binding protein α (C/EBPα) are important for the transcriptional control of coagulation factors...
  56. pmc Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation
    Chad Walesky
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 304:G26-37. 2013
    Hepatocyte nuclear factor-4α (HNF4α) is known as the master regulator of hepatocyte differentiation. Recent studies indicate that HNF4α may inhibit hepatocyte proliferation via mechanisms that have yet to be identified...
  57. pmc Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents
    Chad Walesky
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
    Hepatology 57:2480-90. 2013
    b>Hepatocyte nuclear factor 4 alpha (HNF4α), the master regulator of hepatocyte differentiation, has been recently shown to inhibit hepatocyte proliferation by way of unknown mechanisms...
  58. pmc Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
    G P Hayhurst
    Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 21:1393-403. 2001
    ..Of these, only HNF4alpha (nuclear receptor 2A1) and HNF1alpha appear to be correlated with the differentiated phenotype of cultured hepatoma cells...
  59. ncbi Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors
    Natalia L Lazarevich
    Laboratory of Immunochemistry, Institute of Carcinogenesis, N N Blokhin Cancer Research Center, Moscow, Russia
    Hepatology 39:1038-47. 2004
    ..These alterations were coupled with a reduced expression of several liver transcription factors including HNF4, a factor essential for hepatocyte differentiation...
  60. pmc Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene
    Ewan R Pearson
    Peninsula Medical School, Exeter, United Kingdom
    PLoS Med 4:e118. 2007
    ..hypoglycaemia in patients with heterozygous mutations in the maturity-onset diabetes of the young (MODY) genes HNF4A (encoding HNF-4alpha) and HNF1A/TCF1 (encoding HNF-1alpha), and the effect of pancreatic deletion of Hnf4a on ..
  61. pmc p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101
    J Ruland
    Amgen Institute, 620 University Avenue, Toronto, ON, Canada M5G 2C1
    Proc Natl Acad Sci U S A 98:1859-64. 2001
    ..5. These results demonstrate that tsg101 is essential for the proliferative burst before the onset of gastrulation and establish a functional connection between tsg101 and the p53 pathway in vivo...
  62. ncbi Characterization of the mouse matrilin-4 gene: a 5' antiparallel overlap with the gene encoding the transcription factor RBP-l
    R Wagener
    Institute for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, Cologne, D 50931, Germany
    Genomics 76:89-98. 2001
    ..In situ hybridization of brain sections showed a partially overlapping expression pattern for the two genes...
  63. ncbi The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse
    J Corchero
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Pharmacol 60:1260-7. 2001
    ..2 +/- 0.9 l/h/kg and 16.5 +/- 4.5 h, respectively). Mutations in hepatic nuclear factor 4alpha (HNF4alpha), a hepatic transcription factor known to regulate in vitro expression of the CYP2D6 gene, could affect the ..
  64. ncbi The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis
    Katherine Krupczak-Hollis
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 7170, USA
    Dev Biol 276:74-88. 2004
    ....
  65. doi Expression of HNF4alpha variants in pancreatic islets and Ins-1 beta cells
    Jianmin Huang
    Pediatric Endocrine Unit, MassGeneral Hospital for Children and Harvard Medical School, Boston, MA 02114 2696, USA
    Diabetes Metab Res Rev 24:533-43. 2008
    Hepatocyte nuclear factor (HNF4alpha) is a nuclear receptor essential for endodermal differentiation and cell functions in the adult pancreas, liver, and other tissues. Mutations in the HNF4A gene cause MODY1...
  66. doi Characterization and functional analyses of hepatic mesothelial cells in mouse liver development
    Izumi Onitsuka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Gastroenterology 138:1525-35, 1535.e1-6. 2010
    ..Here we characterized the nature of mouse hepatic mesothelial cells (MCs) and investigated their role in organogenesis...
  67. doi Hepatocyte nuclear factor 4 alpha is related to survival of the condensed mesenchyme in the developing mouse kidney
    Tomonori Kanazawa
    Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Dev Dyn 239:1145-54. 2010
    b>Hepatocyte nuclear factor 4 alpha (Hnf4alpha) is a transcription factor required for embryogenesis and organogenesis. In the adult kidney, Hnf4alpha is expressed at a high level in proximal tubules...
  68. pmc Acyl-CoA binding protein gene ablation induces pre-implantation embryonic lethality in mice
    Danilo Landrock
    Department of Pathobiology, Texas A and M University, TAMU 4467, College Station, TX 77843 4467, USA
    Lipids 45:567-80. 2010
    ..The fact that ACBP is the first known intracellular lipid binding protein whose deletion results in embryonic lethality suggests its vital importance in mammals...
  69. doi Identification of a functional hepatocyte nuclear factor 4 binding site in the neutral ceramidase promoter
    Henrik R Maltesen
    Department of Cellular and Molecular Medicine, University of Copenhagen, The Panum Institute, Bldg 6 4, Blegdamsvej 3, DK2200N, Denmark
    J Cell Biochem 111:1330-6. 2010
    ..The results support the hypothesis that HNF-4α might be important for intestinal glycolipid metabolism...
  70. doi GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells
    Nicolas Jonckheere
    Jean Pierre Aubert Research Center, Lille Cedex, France
    Biochim Biophys Acta 1819:869-76. 2012
    ..This is thus in favor of an important role for these two transcription factors as regulators of expression of the Muc5ac mucin during stomach development and in epithelial cancer cells...
  71. doi Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer
    T Saandi
    INSERM, Unité 682, Strasbourg, France
    Oncogene 32:3782-8. 2013
    ..We have previously established that several endodermal transcription factors, including HNF4α and GATA6, are involved in Cdx2 regulation in the normal gut...
  72. pmc Advancements and challenges in generating accurate animal models of gestational diabetes mellitus
    Raymond C Pasek
    Tennessee Valley Healthcare System, Department of Veteran Affairs, Nashville, Tennessee
    Am J Physiol Endocrinol Metab 305:E1327-38. 2013
    ..Continued development of animal models of GDM is essential for understanding the consequences of this disease as well as providing insights into potential treatments and preventative measures. ..
  73. pmc Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation
    Qin Chen
    Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA and Nephrology Division, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 29:2555-65. 2015
    ..We propose that the decrease in the IGF1R/Akt signaling pathway in mice with mesenchymal overexpression of NO66 may contribute in part to the inhibition of skeletal growth and bone formation...
  74. pmc Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway
    Shengnan Wei
    Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China
    PLoS ONE 11:e0152097. 2016
    ..Our data provide new evidence to support HNF-4α and miR122 regulated hepatic gluconeogenesis and lipid metabolism as promising therapeutic targets for the treatment of T2D. ..
  75. doi The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse
    Vincent Frochot
    Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, UMRS, Paris, France
    Am J Physiol Gastrointest Liver Physiol 302:G1253-63. 2012
    ..We conclude that the transcription factor HNF-4α is a key factor of the intestinal absorption of dietary lipids, which controls this process as early as in the initial step of fatty acid uptake by enterocytes...
  76. pmc Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
    Andre J Faure
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 22:2163-75. 2012
    ..Finally, we observe that the presence of mirrored CTCF binding events at promoters and their nearby cohesin-bound enhancers is associated with elevated expression levels...
  77. pmc Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding
    Michael P Verzi
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Mol Cell Biol 33:281-92. 2013
    ..the embryonic intestinal epithelium, through unknown mechanisms, and partners with transcription factors such as HNF4A in the adult intestine...
  78. ncbi Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4)
    S Hata
    Department of Life Science, Faculty of Science, Himeji Institute of Technology, Hyogo, Japan
    Biochim Biophys Acta 1260:55-61. 1995
    ..Finally, we amplified a DNA fragment (1.1 kb in size) from mouse genomic DNA using the same PCR primers as above. Its nucleotide sequence unequivocally confirmed that different splice donor sites were used to generate the two isoforms...
  79. ncbi The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins
    S L Ang
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Development 119:1301-15. 1993
    ..HFH-E5.1 is highly similar in structure and expression profile to the Drosophila HFH gene FD4, suggesting that HFH family members have different, evolutionarily conserved roles in development...
  80. ncbi Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues
    I Dragatsis
    Department of Genetics, Columbia University, New York, NY 10032, USA
    Development 125:1529-39. 1998
    ....
  81. ncbi Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis
    D Brown
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9148, USA
    Development 126:4317-29. 1999
    ..These results reveal an essential early role for scleraxis in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages, and suggest that scleraxis target genes mediate these processes...
  82. ncbi BMP type II receptor is required for gastrulation and early development of mouse embryos
    H Beppu
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Research for the Future Program, Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, 170 8455, Japan
    Dev Biol 221:249-58. 2000
    ..Our results suggest that the function of BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development...
  83. ncbi Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strain
    T Kayo
    Department of Hygiene, Akita University School of Medicine, Japan
    Comp Med 50:296-302. 2000
    ..05) at 10, 20, and 30 minutes during the intraperitoneal glucose tolerance test (IPGTT: 1.5 g glucose/kg of body weight)...
  84. pmc Hepatocyte nuclear factor 4 response to injury involves a rapid decrease in DNA binding and transactivation via a JAK2 signal transduction pathway
    Xuemei Li
    Boston Medical Center, Department of Surgery, Boston, MA 02118, USA
    Biochem J 368:203-11. 2002
    ..The mechanisms by which HNF-4 is modified after injury involve the activation of Janus kinase 2 (JAK2) signal transduction pathways, but the direct or indirect interaction of JAK2 with HNF-4 remains to be defined...
  85. ncbi Multi-stage analysis of differential gene expression in BALB/C mouse liver development by high-density microarrays
    Andrea Jochheim
    Hannover Medical School, Centre of Internal Medicine, Department of Gastroenterology, Hepatology and Endocrinology, Carl Neubergstr 1, 30625 Hannover, Germany
    Differentiation 71:62-72. 2003
    ..Furthermore, the microarray approach led to the identification of a number of genes, which have not yet been associated with liver organogenesis and maturation...
  86. ncbi Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    Pere Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 423:550-5. 2003
    ..We conclude that FOXO1 and PGC-1alpha interact in the execution of a programme of powerful, insulin-regulated gluconeogenesis...
  87. ncbi Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes
    Koichi Misawa
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 278:36176-82. 2003
    ..These data provide a novel pathway by which HNF-4 potentiates the SREBP functions and stimulates expression of SREBP-responsive genes in enterohepatic cells...
  88. ncbi Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver
    Akihide Kamiya
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bldg 37, Rm 3106B1, 9000 Rockville Pike, Bethesda, MD 20892, USA
    FEBS Lett 578:63-8. 2004
    Adult liver functions are regulated by several hepatocyte nuclear factors (HNFs). HNF4alpha and HNF1alpha are involved in metabolic functions in the liver...
  89. ncbi Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation
    Takako Makita
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 280:59-72. 2005
    ..5 onward is enhancer-independent, and is driven instead by basal promoter elements that provide a sufficient level of expression to support further erythropoietic differentiation...
  90. ncbi Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization
    Seiro Satohisa
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Cell Res 310:66-78. 2005
    ....
  91. pmc Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR
    Aaron W Bell
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 44:186-94. 2006
    ..However, CAR-mediated transcriptional control of some genes is critically dependent on hepatocyte nuclear factor 4 alpha (HNF-4alpha; NR2A1), which itself regulates multiple liver-specific genes involved in hepatic growth,..
  92. ncbi The expression profiles of nuclear receptors in the developing and adult kidney
    Jae Mi Suh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:3412-20. 2006
    ..Our results suggest that these nuclear receptors are likely to play important physiological roles in the kidney development...
  93. doi EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas
    Monika Niehof
    Fraunhofer Institute of Toxicology and Experimental Medicine, Center of Drug Research and Medical Biotechnology, Hannover, Germany
    Gastroenterology 134:1191-202. 2008
    The orphan nuclear receptor HNF4alpha is a member of the hepatic transcription factor network. This protein plays a pivotal role in liver development and hepatocellular differentiation...
  94. pmc Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice
    Roong Zhao
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
    Dev Biol 317:614-9. 2008
    ..Our data support a model whereby GATA4 or GATA6 are essential for expression of the network of transcription factors that regulate the onset of cardiac myocyte gene expression during mammalian development...
  95. pmc Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H
    Jennifer Luebke-Wheeler
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hepatology 48:1242-50. 2008
    Loss of the nuclear hormone receptor hepatocyte nuclear factor 4alpha (HNF4alpha) in hepatocytes results in a complex pleiotropic phenotype that includes a block in hepatocyte differentiation and a severe disruption to liver function...
  96. doi Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells
    Tsunekazu Oikawa
    Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Gastroenterology 136:1000-11. 2009
    ..The expression and functional roles of Sall4 during liver development have not been elucidated. We here provide their first description in hepatoblasts...
  97. pmc Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice
    Mathieu Darsigny
    Canadian Institutes of Health Research Team on Digestive Epithelium, Département d Anatomie et Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 4:e7609. 2009
    b>Hnf4alpha, an epithelial specific transcriptional regulator, is decreased in inflammatory bowel disease and protects against chemically-induced colitis in mice...
  98. pmc Inactivation of hepatocyte nuclear factor-4{alpha} mediates alcohol-induced downregulation of intestinal tight junction proteins
    Wei Zhong
    Dept of Medicine, Univ of Louisville School of Medicine, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 299:G643-51. 2010
    ..These results indicate that inactivation of HNF-4alpha due to oxidative stress and zinc deficiency is likely a novel mechanism contributing to the deleterious effects of alcohol on the tight junctions and the intestinal barrier function...
  99. doi Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway
    Seiichi Koike
    Department of Molecular Neurobiology, Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
    Biochem Biophys Res Commun 400:66-71. 2010
    ..These results reveal the signal transduction defects that underlie the abnormalities in Enpp2(-/-) embryos...
  100. doi The role of hepatocyte nuclear factor 4α in regulating mouse hepatic anticoagulation and fibrinolysis gene transcript levels
    H Safdar
    J Thromb Haemost 8:2839-41. 2010
  101. pmc The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation
    Xiang Zhou
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e16358. 2011
    ..Finally, we provide evidence that mTOR signaling is drastically reduced in Pik3c3 null embryos, which could be a major contributor to the observed proliferation and embryogenesis defects...

Research Grants6

  1. The role of HNF4 in gastrointestinal development
    Michele Battle; Fiscal Year: 2006
    The goals of the proposed studies are to determine if HNF4 is essential for gastrointestinal development, if HNF4 is a central regulator of gastrointestinal gene expression, and if HNF4 controls gene expression by modulating the ..
  2. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  3. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  4. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  6. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..