Hmx1

Summary

Gene Symbol: Hmx1
Description: H6 homeobox 1
Alias: Nkx5-3, homeobox protein HMX1, H6 homeo box 1, homeobox protein H6
Species: mouse

Top Publications

  1. ncbi Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes
    H Y Wang
    Department of Medicine, Department of Pathology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0651, USA
    Genomics 57:310-5. 1999
  2. doi Identification of the minimal promoter region of the mouse NKX5-3, a transcription factor implicated in eye development
    Olivia Nichini
    Institute for Research in Ophthalmology, Sion, Switzerland
    Gene 411:10-8. 2008
  3. ncbi Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family
    H S Stadler
    University of Iowa, Department of Biological Sciences, Iowa City 52242, USA
    Mamm Genome 6:383-8. 1995
  4. pmc Identification of HMX1 target genes: a predictive promoter model approach
    Arnaud Boulling
    Institute for Research in Ophthalmology, Sion, Switzerland
    Mol Vis 19:1779-94. 2013
  5. pmc The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification
    Alessandro Furlan
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden
    EMBO J 32:1613-25. 2013
  6. pmc Deletion of a conserved regulatory element required for Hmx1 expression in craniofacial mesenchyme in the dumbo rat: a newly identified cause of congenital ear malformation
    Lely A Quina
    Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, WA 98101, USA
    Dis Model Mech 5:812-22. 2012
  7. pmc Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion
    Lely A Quina
    Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, WA 98101, USA
    Dev Biol 365:152-63. 2012
  8. pmc Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass
    Robert J Munroe
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    BMC Dev Biol 9:27. 2009
  9. pmc Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome
    Daniel F Schorderet
    Institut de Recherche en Ophtalmologie, 1950 Sion, Switzerland
    Am J Hum Genet 82:1178-84. 2008
  10. pmc Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations
    Lawriston Wilson
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genome Res 15:1095-105. 2005

Scientific Experts

  • B A Amendt
  • Robert J Munroe
  • Daniel F Schorderet
  • Lely A Quina
  • Eric E Turner
  • Timothy C Cox
  • Yung Hao Ching
  • Jessica M Rosin
  • Jutta Stubbusch
  • W Wang
  • Christophe Laumonnerie
  • Xiao Yue Li
  • Fabienne Marcelli
  • Takashi Kuramoto
  • Arnaud Boulling
  • Alessandro Furlan
  • Olivia Nichini
  • John C Schimenti
  • T Lufkin
  • Lawriston Wilson
  • Sara M Rolfe
  • Wenjie Li
  • Víctor Latorre
  • Jennifer A Akiyama
  • Liza L Cox
  • Nicoletta Bobola
  • Axel Visel
  • Ruth Simon
  • Filippo M Rijli
  • Priyanka Narasimhan
  • Yukiko Kurihara
  • Hermann Rohrer
  • Nathalie Vilain
  • Melanie Hennchen
  • Hiroki Kurihara
  • Katrin Huber
  • Ahmad Bechara
  • Klaus Unsicker
  • Uwe Ernsberger
  • Gaelle Boisset
  • Ke Zhang
  • Zhi Yi Jiang
  • Li Hua Cai
  • Patrik Ernfors
  • Linda Wicht
  • Moritz Lübke
  • Francois Lallemend
  • K Yoshiura
  • Igor Adameyko
  • Daniela V Luquetti
  • Tadao Serikawa
  • Yun Wei A Hsu
  • Lynne Tempest
  • Tanya P Harris
  • Anna K Barker
  • Frederica Dipalma
  • Kerry J Schimenti
  • Yunhai Luo
  • Erin K Stenson
  • Lindsay M Abcunas
  • Jennifer L Moran
  • Lishuang Shen
  • Tim Fennell
  • David L Rogal
  • Kerstin Lindblad-Toh
  • Mami Shindo
  • Joyanna F Gilmour
  • Susan L Kloet
  • C L Taylor Clelland
  • James Y Shou
  • Weipeng Mu
  • John L McElwee
  • Hyo K Park
  • Evan Mauceli
  • Patrick J Stover
  • H Y Wang
  • Michael Farias
  • Suzanne A Hartford
  • Hongguang Shao
  • Gareth Howell
  • Maja Bucan
  • Thomas Lufkin
  • J C Murray
  • N J Leysens
  • P Lo
  • L Craciun
  • M Frasch
  • C Bancroft
  • H S Stadler
  • J R Bermingham

Detail Information

Publications24

  1. ncbi Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes
    H Y Wang
    Department of Medicine, Department of Pathology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0651, USA
    Genomics 57:310-5. 1999
    ..1 (a region of conserved synteny to mouse Chromosome 5). In addition, we also found multiple SRPK-related sequences on other human chromosomes, one of which appears to correspond to a SRPK2 pseudogene on human chromosome 8...
  2. doi Identification of the minimal promoter region of the mouse NKX5-3, a transcription factor implicated in eye development
    Olivia Nichini
    Institute for Research in Ophthalmology, Sion, Switzerland
    Gene 411:10-8. 2008
    ..Altogether, these results demonstrated that the immediate upstream region of Nkx5-3 gene possessed a strong intrinsic promoter activity in vitro, suggesting a potential role in Nkx5-3 transcription in vivo...
  3. ncbi Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family
    H S Stadler
    University of Iowa, Department of Biological Sciences, Iowa City 52242, USA
    Mamm Genome 6:383-8. 1995
    ..melanogaster (fruit fly)...
  4. pmc Identification of HMX1 target genes: a predictive promoter model approach
    Arnaud Boulling
    Institute for Research in Ophthalmology, Sion, Switzerland
    Mol Vis 19:1779-94. 2013
    A homozygous mutation in the H6 family homeobox 1 (HMX1) gene is responsible for a new oculoauricular defect leading to eye and auricular developmental abnormalities as well as early retinal degeneration (MIM 612109)...
  5. pmc The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification
    Alessandro Furlan
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden
    EMBO J 32:1613-25. 2013
    ..The homeobox transcription factor HMX1 represses Tlx3 and Ret, induces TrkA and maintains tyrosine hydroxylase (Th) expression in precursors, thus driving ..
  6. pmc Deletion of a conserved regulatory element required for Hmx1 expression in craniofacial mesenchyme in the dumbo rat: a newly identified cause of congenital ear malformation
    Lely A Quina
    Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, WA 98101, USA
    Dis Model Mech 5:812-22. 2012
    b>Hmx1 is a homeodomain transcription factor expressed in the developing eye, peripheral ganglia, and branchial arches of avian and mammalian embryos...
  7. pmc Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion
    Lely A Quina
    Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, WA 98101, USA
    Dev Biol 365:152-63. 2012
    b>Hmx1 is a variant homeodomain transcription factor expressed in the developing sensory nervous system, retina, and craniofacial mesenchyme...
  8. pmc Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass
    Robert J Munroe
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    BMC Dev Biol 9:27. 2009
    The H6 homeobox genes Hmx1, Hmx2, and Hmx3 (also known as Nkx5-3; Nkx5-2 and Nkx5-1, respectively), compose a family within the NKL subclass of the ANTP class of homeobox genes...
  9. pmc Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome
    Daniel F Schorderet
    Institut de Recherche en Ophtalmologie, 1950 Sion, Switzerland
    Am J Hum Genet 82:1178-84. 2008
    ..Morpholino knockdown expression of the zebrafish nkx5-3 induced microphthalmia and disorganization of the developing retina, thus confirming that this gene represents an additional member implicated in axial patterning of the retina...
  10. pmc Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations
    Lawriston Wilson
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genome Res 15:1095-105. 2005
    ..By pooling the data from this and other region-specific mutagenesis projects, we calculate that the mouse genome contains approximately 3479-4825 embryonic lethal genes, or about 13.7%-19% of all genes...
  11. ncbi Cloning, characterization, and mapping of the mouse homeobox gene Hmx1
    K Yoshiura
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Genomics 50:61-8. 1998
    ..We previously isolated the human HMX1 (H6) gene, a novel homeobox-containing gene of the HMX family, from a human embryonic craniofacial cDNA library...
  12. ncbi Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
    W Wang
    Brookdale Center for Development and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Development 125:621-34. 1998
    ..The three members of the murine Hmx family, designated Hmx1, Hmx2 and Hmx3, are expressed in tissues that suggest a common functional role in sensory organ development and ..
  13. ncbi Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 99:123-37. 2000
    ..three genes to previously identified genes in sea urchin, chick and human, as well as the recently cloned murine Hmx1 gene, and the low homology to other homeobox genes indicate that the Hmx genes comprise a novel gene family...
  14. ncbi Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site
    B A Amendt
    Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 274:11635-42. 1999
    ..the 5'-CAAG-3' core and the 3'-TG dinucleotide are required for high affinity binding by Hmx3 and the homologous Hmx1 protein...
  15. doi MiR-204/miR-211 downregulation contributes to candidemia-induced kidney injuries via derepression of Hmx1 expression
    Xiao Yue Li
    Department of Critical Care Medicine, Dongguan People s Hospital, Dongguan, Guangdong 523059, China
    Life Sci 102:139-44. 2014
    This study was aimed to exploit the role of heme oxygenase Hmx1 and the potential miRNA mechanisms in the kidney injuries induced by urinary tract infection by Candida species/Candidemia.
  16. pmc A dimerized HMX1 inhibits EPHA6/epha4b in mouse and zebrafish retinas
    Fabienne Marcelli
    IRO Institute for Research in Ophthalmology, Sion, Switzerland Faculty of Life Sciences, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    PLoS ONE 9:e100096. 2014
    b>HMX1 is a homeobox-containing transcription factor implicated in eye development and responsible for the oculo-auricular syndrome of Schorderet-Munier-Franceschetti...
  17. doi Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance
    Jutta Stubbusch
    Max Planck Institute for Brain Research, Research Group Developmental Neurobiology, Max von Laue Street 4, 60438 Frankfurt Main, Germany
    Dev Biol 400:210-23. 2015
    ..Taken together, these findings demonstrate distinct stage and lineage specific functions of Dicer1 signaling in differentiation and survival of sympathetic neurons and adrenal chromaffin cells...
  18. doi Facial whisker pattern is not sufficient to instruct a whisker-related topographic map in the mouse somatosensory brainstem
    Christophe Laumonnerie
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel 4058, Switzerland
    Development 142:3704-12. 2015
    ..These results provide novel insights into periphery-dependent versus periphery-independent mechanisms of trigeminal ganglion and brainstem patterning in matching whisker topography. ..
  19. pmc A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex
    Jessica M Rosin
    Center for Developmental Biology and Regenerative Medicine, Seattle Children s Research Institute, Seattle, WA 98101, USA
    Development 143:2582-92. 2016
    b>Hmx1 encodes a homeodomain transcription factor expressed in the developing lateral craniofacial mesenchyme, retina and sensory ganglia...
  20. pmc High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5
    Yung Hao Ching
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    BMC Genet 11:106. 2010
    ..Previously, a large scale ENU mutagenesis screen was conducted to query the functional content of a ~50 Mb region of the mouse genome on proximal Chr 5. The majority of phenotypic mutants recovered were embryonic lethals...
  21. pmc Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation
    Ruth Simon
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mol Cell Biol 23:9046-60. 2003
    ..Intriguingly, our studies also demonstrated a striking autoregulation of the Sax2 gene in both positive- and negative-feedback mechanisms depending on the specific cell type expressing Sax2...
  22. ncbi Mapping and developmental expression analysis of the WD-repeat gene Preb
    C L Taylor Clelland
    Department of Physiology and Biophysics, Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, 10029 6574, USA
    Genomics 63:391-9. 2000
    ..Preb maps to the proximal end of chromosome 5 in mouse, near the Hmx1 homeobox gene...
  23. ncbi Assignment of the murine Hmx1 homeobox gene to the proximal region of mouse chromosome 5
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Mamm Genome 8:869-70. 1997
  24. ncbi The effects of dopamine and isoproterenol on the pulmonary circulation
    R M Mentzer
    J Thorac Cardiovasc Surg 71:807-14. 1976
    ..If these findings can be extrapolated to man, isoproterenol may be the preferred inotropic agent in patients with an elevated pulmonary vascular resistance...