Hmgcr

Summary

Gene Symbol: Hmgcr
Description: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Alias: HMG-CoAR, Red, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoA reductase
Species: mouse

Top Publications

  1. pmc Renal ischemia-induced cholesterol loading: transcription factor recruitment and chromatin remodeling along the HMG CoA reductase gene
    Masayo Naito
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Pathol 174:54-62. 2009
  2. ncbi Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene
    Ken Ohashi
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 278:42936-41. 2003
  3. ncbi Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis
    Zrinka Marijanovic
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Mol Endocrinol 17:1715-25. 2003
  4. pmc Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver
    Seonghwan Hwang
    From the Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046
    J Biol Chem 291:13479-94. 2016
  5. pmc SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression
    Laurent Vergnes
    Departments of Human Genetics David Geffen School of Medicine at the University of California, Los Angeles, CA 90095
    J Lipid Res 57:410-21. 2016
  6. pmc Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity
    Tatiana L Fonseca
    Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, IL 60612
    Proc Natl Acad Sci U S A 112:14018-23. 2015
  7. doi Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy
    Yoshinori Osaki
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan Department of Internal Medicine Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 466:536-40. 2015
  8. pmc Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis
    Hongjin Lu
    Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    Steroids 99:219-29. 2015
  9. pmc Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver
    Xiujuan Zhang
    Departments of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
    J Lipid Res 56:963-71. 2015
  10. pmc Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development
    David Cunningham
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA
    Hum Mol Genet 24:2808-25. 2015

Scientific Experts

  • Shinya Hasegawa
  • Nina Raben
  • Mitsuru Watanabe
  • Carrie L Welch
  • Tony Hayek
  • S Hanaka
  • Nobuya Shirai
  • Zeljka Korade
  • Jiaxi Ding
  • Anne Beigneux
  • Ken Ohashi
  • Shun Ishibashi
  • Seonghwan Hwang
  • Laurent Vergnes
  • Tatiana L Fonseca
  • Hongjin Lu
  • Yoshinori Osaki
  • Xiujuan Zhang
  • David Cunningham
  • Debabrata Patra
  • Yaxi Chen
  • Christie M Buchovecky
  • Yien Che Tsai
  • Zhekang Ying
  • Shuichi Nagashima
  • Sung Yun Cho
  • Parshuram J Sonawane
  • Dragana D Bojanic
  • Guosheng Liang
  • Nobuhiro Yamada
  • Abdur Rub
  • Hitoshi Shimano
  • Masayo Naito
  • Naoya Yahagi
  • Dana Schiefelbein
  • Hiroaki Yagyu
  • Motohiro Sekiya
  • Jun Ichi Osuga
  • Michele K Wu
  • Luke J Engelking
  • Timothy B Langston
  • Pilar Yubero
  • David E Cohen
  • Matthew A Mitsche
  • Stephen G Young
  • A S Plump
  • Kristina Garland
  • Gennipher A Young
  • Luke Engelking
  • Thomas de Aguiar Vallim
  • Loren G Fong
  • Leona N Calhoun
  • Zrinka Marijanovic
  • Russell A DeBose-Boyd
  • Robert G Chin
  • Karen Reue
  • Isamu Z Hartman
  • Jeffrey McDonald
  • Timothy F Osborne
  • Fang Xu
  • Thorsten Forster
  • Hiroaki Suzuki
  • Xiaoyun Xing
  • Csaba Fekete
  • Yoshimi Nakagawa
  • Ting Wang
  • Kevin A Robertson
  • Jiajun Zhao
  • Simon Talbot
  • Mei Feng
  • Natalie Bir
  • Antonio C Bianco
  • Louise S Merkens
  • Elizabeth A McAninch
  • Yingli Lu
  • Balazs Gereben
  • Akiko Ishii
  • Ling Gao
  • Gustavo W Fernandes
  • Gail E Herman
  • Xinli Zhou
  • Akimitsu Takahashi
  • Sherine M Abdalla
  • Daofeng Li
  • Xiuyun Jiang
  • Barbara M L C Bocco
  • Andrea E DeBarber
  • Yongfeng Song
  • Kazuto Kobayashi
  • Douglas Roy

Detail Information

Publications50

  1. pmc Renal ischemia-induced cholesterol loading: transcription factor recruitment and chromatin remodeling along the HMG CoA reductase gene
    Masayo Naito
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Pathol 174:54-62. 2009
    ..However, the factors during acute kidney injury that regulate HMG CoA reductase (HMGCR) activity, the rate-limiting step in cholesterol synthesis, have not been defined...
  2. ncbi Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene
    Ken Ohashi
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 278:42936-41. 2003
    ..We used gene targeting to knock out the mouse HMG-CoA reductase gene. The heterozygous mutant mice (Hmgcr+/-) appeared normal in their development and gross anatomy and were fertile...
  3. ncbi Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis
    Zrinka Marijanovic
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Mol Endocrinol 17:1715-25. 2003
    ..In its function as the 3-ketosteroid reductase of cholesterol biosynthesis, HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism...
  4. pmc Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver
    Seonghwan Hwang
    From the Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046
    J Biol Chem 291:13479-94. 2016
    ..endoplasmic reticulum membranes stimulates the ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which catalyzes a rate-limiting step in synthesis of cholesterol...
  5. pmc SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression
    Laurent Vergnes
    Departments of Human Genetics David Geffen School of Medicine at the University of California, Los Angeles, CA 90095
    J Lipid Res 57:410-21. 2016
    ..Reduced expression of SREBP-2 from the hypomorphic allele leads to early death in females and reduced cholesterol content in the liver, but not in adipose tissue. ..
  6. pmc Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity
    Tatiana L Fonseca
    Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, IL 60612
    Proc Natl Acad Sci U S A 112:14018-23. 2015
    ..The resulting phenotype of the adult ALB-D2KO mouse is dramatic, with greatly reduced susceptibility to diet-induced steatosis, hypertriglyceridemia, and obesity. ..
  7. doi Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy
    Yoshinori Osaki
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan Department of Internal Medicine Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 466:536-40. 2015
    HMG-CoA reductase (HMGCR) catalyzes the conversion of HMG-CoA to mevalonic acid (MVA); this is the rate-limiting enzyme of the mevalonate pathway that synthesizes cholesterol...
  8. pmc Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis
    Hongjin Lu
    Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    Steroids 99:219-29. 2015
    ..IFN controls the first regulated step in the mevalonate-sterol pathway, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), through the synthesis of 25-Hydroxycholesterol (25-HC) from cholesterol by the IFN-inducible Cholesterol-25-..
  9. pmc Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver
    Xiujuan Zhang
    Departments of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
    J Lipid Res 56:963-71. 2015
    Cholesterol homeostasis is strictly regulated through the modulation of HMG-CoA reductase (HMGCR), the rate-limiting enzyme of cholesterol synthesis. Phosphorylation of HMGCR inactivates it and dephosphorylation activates it...
  10. pmc Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development
    David Cunningham
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA
    Hum Mol Genet 24:2808-25. 2015
    ..They further emphasize the complex ramifications of cholesterogenic enzyme deficiency on cellular metabolism. ..
  11. pmc Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis
    Debabrata Patra
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 9:e105674. 2014
    ..This role appears not to be related to lipid pathways or other current known functions of S1P and is likely dependent on additional, yet unknown, S1P substrates in chondrocytes. ..
  12. doi Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation
    Yaxi Chen
    From the Key Laboratory of Metabolism on Lipid and Glucose, Centre for Lipid Research, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China Y C, L Z, Q L, A H, X Z R Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan L C L and John Moorhead Research Laboratory, Centre for Nephrology, University College London UCL Medical School, United Kingdom H K, D C W, Z V, J F M, S H P, X Z R
    Arterioscler Thromb Vasc Biol 34:365-76. 2014
    ....
  13. doi Acetoacetyl-CoA synthetase is essential for normal neuronal development
    Shinya Hasegawa
    Department of Health Chemistry, Hoshi University, Ebara, Shinagawa, Tokyo 142 8501, Japan
    Biochem Biophys Res Commun 427:398-403. 2012
    ..These results suggest that AACS is regulated by SREBP-2 and involves in the normal development of neurons...
  14. pmc Modified methylenedioxyphenol analogs lower LDL cholesterol through induction of LDL receptor expression
    Zhekang Ying
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA
    J Lipid Res 53:879-87. 2012
    ..INV-403 lowered plasma LDL cholesterol levels through LDLR upregulation. These results indicate a role for small molecule approaches other than statins for lowering LDL cholesterol...
  15. doi Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death
    Shuichi Nagashima
    Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Arterioscler Thromb Vasc Biol 32:1824-31. 2012
    3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) catalyzes the rate-limiting step in cholesterol biosynthesis and has proven to be an effective target of lipid-lowering drugs, statins...
  16. pmc Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, MD 20712, USA
    Mol Biol Cell 23:4484-94. 2012
    ..Our results suggest a need for additional studies before definitive mechanistic conclusions are drawn that might set the stage for development of drugs to manipulate gp78 function in metabolic disorders...
  17. pmc A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome
    Christie M Buchovecky
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 45:1013-20. 2013
    ..Our genetic screen therefore points to cholesterol homeostasis as a potential target for the treatment of patients with Rett syndrome. ..
  18. ncbi Macrophage NADPH oxidase activation, impaired cholesterol fluxes, and increased cholesterol biosynthesis in diabetic mice: a stimulatory role for D-glucose
    Tony Hayek
    Lipid Research Laboratory, Faculty of Medicine, Technion, Rambam Medical Center, Haifa, Israel
    Atherosclerosis 195:277-86. 2007
    ..The above mechanisms in diabetic mice could be the result of the effect of high D-glucose on macrophages...
  19. doi Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms
    Sung Yun Cho
    Department of Biotechnology, The Graduate School of Biotechnology, Korea University, Seoul, Republic of Korea
    FEBS Lett 585:3289-96. 2011
    ..These findings suggest that food molecules with a pleasant scent could exert beneficial metabolic effects through multiple mechanisms...
  20. doi Effects of buckwheat sprouts on plasma and hepatic parameters in type 2 diabetic db/db mice
    Mitsuru Watanabe
    Natl Agricultural Research Center for Tohoku Region, 4 Akahira, Shimokuriyagawa, Morioka, Iwate 020 0198, Japan
    J Food Sci 75:H294-9. 2010
    ..It was deduced that excretion of bile acids in feces by feeding the BS diet would contribute to the suppression of the cholesterol concentration in the plasma and liver tissues of mice...
  21. pmc Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension
    Parshuram J Sonawane
    Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India
    PLoS ONE 6:e16661. 2011
    3-Hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase gene (Hmgcr) is a susceptibility gene for essential hypertension...
  22. pmc Differential expression and function of ABCG1 and ABCG4 during development and aging
    Dragana D Bojanic
    Department of Biological Chemistry at UCLA Los Angeles, CA 90095, USA
    J Lipid Res 51:169-81. 2010
    ..Finally, behavioral tests show that Abcg4(-/-) mice have a general deficit in associative fear memory. Together, these data indicate that loss of ABCG1 and/or ABCG4 from the CNS results in changes in metabolic pathways and in behavior...
  23. doi Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function
    Abdur Rub
    National Centre for Cell Science, Ganeshkhind, Pune 411007, India
    Nat Immunol 10:273-80. 2009
    ..Thus, cholesterol depletion might represent an immune-evasion strategy used by L. major...
  24. pmc Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse
    Jiaxi Ding
    Department of Genetics Case Western Reserve University, Cleveland, OH, USA
    BMC Dev Biol 8:120. 2008
    ..Primordial germ cells (PGCs) are the embryonic precursors of the sperm and eggs. Environmental or genetic defects that alter PGC development can impair fertility or cause formation of germ cell tumors...
  25. pmc NRIF is a regulator of neuronal cholesterol biosynthesis genes
    Zeljka Korade
    Department of Biochemistry, Vanderbilt University School of Medicine, 8124A MRB III, Nashville, TN 37232, USA
    J Mol Neurosci 38:152-8. 2009
    ..decreased the mRNA for two main cholesterogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr; EC 2.3.3.10) and 7-dehydrocholesterol reductase (Dhcr7; EC 1.3.1.21)...
  26. ncbi Purification of brain peroxisomes and localization of 3-hydroxy-3-methylglutaryl coenzyme A reductase
    W J Kovacs
    Department of Biology, San Diego State University, San Diego, CA 92182, USA
    Eur J Biochem 268:4850-9. 2001
    ..In addition, we show by analytical subcellular fractionation and immunoelectron microscopy that HMG-CoA reductase protein and activity are localized both in the ER and peroxisomes in the CNS...
  27. ncbi Glucocorticoid-regulated gene expression in the immune system. Analysis of glucocorticoid-regulated transcripts from the mouse macrophage-like cell line P388D1
    A Helmberg
    Institute for General and Experimental Pathology, University of Innsbruck, Austria
    J Immunol 145:4332-7. 1990
    ..Our results raise the possibility that the immunosuppressive activity of glucocorticoids might be mediated, in part, by regulating the expression of the above immunoregulatory proteins...
  28. ncbi Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13
    S Sundaresan
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut
    Somat Cell Mol Genet 15:465-9. 1989
    ..The human gene (HMGCR) has been assigned to the q13.3-q14 region of chromosome 5 (HSA5)...
  29. ncbi Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice
    J F Goodrum
    Brain and Development Research Center, University of North Carolina at Chapel Hill 27599
    J Neurochem 64:408-16. 1995
    ..These data suggest that there is considerable redundancy in the process of cholesterol reutilization within nerve, and that apolipoproteins other than apolipoproteins E and A-I may be involved in the recycling of myelin cholesterol...
  30. ncbi Nucleotide sequence of mouse spermidine synthase cDNA
    S Myöhänen
    Department of Biochemistry and Biotechnology, University of Kuopio, Finland
    DNA Seq 4:343-6. 1994
    ..The open reading frame encoded a polypeptide of 302 amino acids, displaying 95% similarity to human and 33% similarity to E. coli spermidine synthase. The 3' flanking region contained an unusual polyadenylation signal AATACA...
  31. ncbi Genomic structure, chromosomal location, and evolution of the mouse Hox 8 gene
    J R Bell
    Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles 90033
    Genomics 16:123-31. 1993
    ..abstract truncated at 250 words)..
  32. pmc Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York 10021, USA
    J Clin Invest 97:2660-71. 1996
    ....
  33. pmc Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    H Shimano
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Clin Invest 98:1575-84. 1996
    ..The mRNAs encoding 3-hydroxy-3-methylglutaryl CoA (HMG CoA) synthase, HMG CoA reductase, squalene synthase, acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase-1 were all ..
  34. ncbi ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes
    A S Plump
    Laboratory of Biochemical, Genetics, and Metabolism, Rockefeller University, New York, NY 10021, USA
    J Lipid Res 38:1033-47. 1997
    ..In the apoA-I knockout mouse model it appears that low HDL levels create a new steady state in which decreased cholesterol is delivered to both peripheral tissues and the liver...
  35. ncbi Gene expression related to cholesterol metabolism in mouse brain during development
    S Hanaka
    Department of Pediatrics, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, 173 8605, Tokyo, Japan
    Brain Dev 22:321-6. 2000
    ....
  36. ncbi Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice
    D D Patel
    Lipoprotein Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, UK
    J Lipid Res 42:328-37. 2001
    ..Patel, D. D., B. L. Knight, D. Wiggins, S. M. Humphreys, and G. F. Gibbons. Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice. J. Lipid Res. 2001. 42: 328--337...
  37. pmc Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses
    Dana Schiefelbein
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Frankfurt am Main, Germany
    J Biol Chem 283:15479-90. 2008
    ....
  38. ncbi Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis
    Sietske Hogenboom
    Laboratory for Genetic Metabolic Diseases F0 224, Department of Pediatrics, Emma Children s Hospital, Academic Medical Center, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    J Lipid Res 43:90-8. 2002
    ..Our data provide an explanation for the conflicting findings in the literature and show that great care should be taken in the interpretation of data obtained in postmortem material...
  39. ncbi Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts
    Hideyuki Hyogo
    Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 277:34117-24. 2002
    ..Cholesterol gallstone formation during weight loss in ob/ob mice appears to represent a pathologic consequence of an adaptive response that prevents absorption of biliary and dietary cholesterol...
  40. ncbi Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme
    Nina Raben
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Ther 6:601-8. 2002
    ..The results demonstrate that complete reversal of pathology in skeletal muscle or long-affected heart muscle will require much more enzyme than previously expected or a different approach...
  41. pmc ATP-citrate lyase deficiency in the mouse
    Anne P Beigneux
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141, USA
    J Biol Chem 279:9557-64. 2004
    ..The Acly knockout allele is useful for identifying cell types with a high demand for acetyl-CoA synthesis...
  42. ncbi Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strain
    Carrie L Welch
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    Physiol Genomics 17:48-59. 2004
    ..003 and P = 0.0001 for HDL-C and non-HDL-C levels, respectively). These data are consistent with polygenic inheritance of HDL-C levels in the mouse model and provide candidate loci for HDL-C and non-HDL-C level determination in humans...
  43. ncbi The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism
    Pilar Yubero
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain
    Endocrinology 145:4268-77. 2004
    ....
  44. ncbi Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1
    Timothy B Langston
    Departments of Biochemistry and Molecular Biophysics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Lipids 40:31-8. 2005
    ..These results demonstrate elevation of FC and depletion of cholesteryl esters by over-expression of hncCEH, which were resistant to compensatory responses by other enzymes of cholesterol homeostasis...
  45. ncbi Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice
    Michele K Wu
    Department of Biochemistry, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Physiol Gastrointest Liver Physiol 289:G456-61. 2005
    ..We speculate that regulation of cholesterol homeostasis is a physiological function of PC-TP in liver, which can be overcome with a cholesterol-rich lithogenic diet...
  46. pmc Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
    Luke J Engelking
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Clin Invest 115:2489-98. 2005
    ..These studies indicate that the essential elements of the regulatory pathway for lipid synthesis function in liver as they do in cultured cells...
  47. ncbi Effect of docosahexaenoic acid on brain 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in male ICR mice
    Nobuya Shirai
    National Food Research Institute, Tsukuba, Ibaraki 305 8642, Japan
    J Nutr Biochem 18:488-94. 2007
    ..The DHA percentages of brain and liver microsomal fractions increased with the intake of DHA-EE in adult and aged mice. These results suggest that DHA may enhance brain HMG-CoA reductase activity in aged mice...
  48. ncbi Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression
    J J Hwa
    Department of Medicine, University of California, Los Angeles 90024
    J Lipid Res 33:711-25. 1992
    ..The variation provides a striking example, at the molecular level, of the importance of dietary-genetic interactions in the control of cholesterol metabolism...
  49. ncbi An integrated genetic map of the pearl locus of mouse chromosome 13
    A B Seymour
    Department of Human Genetics, University of Pittsburgh, Pennsylvania 15213, USA
    Genome Res 6:538-44. 1996
    ..As-1), thrombin receptor (Cf2r), hexosaminidase b(Hexb), 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgcr), microtubule associated protein 5/1b (Mtap5), phosphodiesterase (Pde), phosphatidylinositol 3' kinase (Pik3rl), ..