Hmgb1

Summary

Gene Symbol: Hmgb1
Description: high mobility group box 1
Alias: HMG-1, Hmg1, SBP-1, p30, high mobility group protein B1, amphoterin, high mobility group protein 1
Species: mouse

Top Publications

  1. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
  2. ncbi Early release of HMGB-1 from neurons after the onset of brain ischemia
    Jianhua Qiu
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 28:927-38. 2008
  3. pmc Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β
    Nicolas Dupont
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    EMBO J 30:4701-11. 2011
  4. ncbi High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo
    G Faraco
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    J Neurochem 103:590-603. 2007
  5. doi High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4
    Xiao Mei Zhu
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, People s Republic of China
    Cytokine 54:296-304. 2011
  6. ncbi HMGB1: a novel Beclin 1-binding protein active in autophagy
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 6:1209-11. 2010
  7. doi High-mobility group box 1 protein in human and murine skin: involvement in wound healing
    Stefania Straino
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Invest Dermatol 128:1545-53. 2008
  8. pmc Stimulation of erythroleukaemia cell differentiation by extracellular high-mobility group-box protein 1 is independent of the receptor for advanced glycation end-products
    Bianca Sparatore
    Biochemistry Section, Department of Experimental Medicine, University of Genoa, Viale Benedetto XV, 1 16132 Genoa, Italy
    Biochem J 363:529-35. 2002
  9. ncbi Cutting edge: extracellular high mobility group box-1 protein is a proangiogenic cytokine
    Stefania Mitola
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brecia, Brescia, Italy
    J Immunol 176:12-5. 2006
  10. pmc High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice
    Rina Takamiya
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 41:129-35. 2009

Research Grants

  1. Regulation of the Ocular Immune Response by Retinal Pigment Epithelium
    Hui Shao; Fiscal Year: 2007
  2. GENERAL CLINICAL RESEARCH CENTER
    Kevin J Tracey; Fiscal Year: 2010
  3. The role of costimulatory molecules in uveitis
    Hui Shao; Fiscal Year: 2011
  4. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
  5. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications152 found, 100 shown here

  1. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
    High mobility group box 1 (HMGB1) protein, originally described as a DNA-binding protein that stabilizes nucleosomes and facilitates transcription, can also be released extracellularly during acute inflammatory responses...
  2. ncbi Early release of HMGB-1 from neurons after the onset of brain ischemia
    Jianhua Qiu
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 28:927-38. 2008
    ..In conclusion, HMGB-1 is released early after ischemic injury from neurons and may contribute to the initial stages of the inflammatory response...
  3. pmc Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β
    Nicolas Dupont
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    EMBO J 30:4701-11. 2011
    ..It enables a subset of cytosolic proteins devoid of signal peptide sequences, and thus unable to access the conventional pathway through the ER, to enter an autophagy-based secretory pathway facilitating their exit from the cytoplasm...
  4. ncbi High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo
    G Faraco
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    J Neurochem 103:590-603. 2007
    ..The evidence indicates that extracellularly released high mobility group box 1 (HMGB1) protein behaves as a cytokine, promoting inflammation and participating to the pathogenesis of several disorders ..
  5. doi High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4
    Xiao Mei Zhu
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, People s Republic of China
    Cytokine 54:296-304. 2011
    High mobility group box-1 protein (HMGB1), a recently recognized mediator of immune response might contribute to immune suppression when released extracellularly...
  6. ncbi HMGB1: a novel Beclin 1-binding protein active in autophagy
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 6:1209-11. 2010
    ..We have found that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is ..
  7. doi High-mobility group box 1 protein in human and murine skin: involvement in wound healing
    Stefania Straino
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Invest Dermatol 128:1545-53. 2008
    High-mobility group box 1 (HMGB1) protein is a multifunctional cytokine involved in inflammatory responses and tissue repair...
  8. pmc Stimulation of erythroleukaemia cell differentiation by extracellular high-mobility group-box protein 1 is independent of the receptor for advanced glycation end-products
    Bianca Sparatore
    Biochemistry Section, Department of Experimental Medicine, University of Genoa, Viale Benedetto XV, 1 16132 Genoa, Italy
    Biochem J 363:529-35. 2002
    In several cell types the binding of extracellular high-mobility group-box protein 1 (HMGB1) with the receptor for advanced glycation end-products (RAGE) induces cytoskeletal reorganization and cell motility...
  9. ncbi Cutting edge: extracellular high mobility group box-1 protein is a proangiogenic cytokine
    Stefania Mitola
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brecia, Brescia, Italy
    J Immunol 176:12-5. 2006
    The chromosomal high mobility group box-1 (HMGB1) protein acts as a proinflammatory cytokine when released in the extracellular environment by necrotic and inflammatory cells...
  10. pmc High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice
    Rina Takamiya
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 41:129-35. 2009
    High-mobility group box 1 (HMGB1) is a nuclear protein that has been found to be a critical mediator of lethality in endotoxemia and sepsis...
  11. doi Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo
    Konstantin Tsoyi
    Department of Pharmacology, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea
    Mol Pharmacol 76:173-82. 2009
    ..that heme-oxygenase-1 (HO-1)-derived carbon monoxide (CO) inhibits the release of high-mobility group box 1 (HMGB1) in RAW264...
  12. pmc High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity
    John Evankovich
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 285:39888-97. 2010
    The mobilization and extracellular release of nuclear high mobility group box-1 (HMGB1) by ischemic cells activates inflammatory pathways following liver ischemia/reperfusion (I/R) injury...
  13. doi High mobility group box 1 protein suppresses T cell-mediated immunity via CD11c(low)CD45RB(high) dendritic cell differentiation
    Qing Yang Liu
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, PR China
    Cytokine 54:205-11. 2011
    High mobility group box 1 protein (HMGB1) has been identified as a late proinflammatory cytokine and plays a key role in immune regulation...
  14. pmc The high-mobility group box-1 nuclear factor mediates retinal injury after ischemia reperfusion
    Galina Dvoriantchikova
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Invest Ophthalmol Vis Sci 52:7187-94. 2011
    High-mobility group protein B1 (Hmgb1) is released from necrotic cells and induces an inflammatory response...
  15. doi High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy
    Yi Luo
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Eur J Cancer 49:741-51. 2013
    The role of the high mobility group box 1 (HMGB1) protein in chemotherapy-induced cell death was examined. CT26 mouse colon cancer cells were treated with trichostatin A (TSA; apoptosis inducer) or doxorubicin (DXR; necrosis inducer)...
  16. pmc Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus
    Dara Ditsworth
    Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:17845-54. 2007
    ..One mediator of this activation is high mobility group box 1 protein (HMGB1). HMGB1 is normally a chromatin-associated protein and is sequestered at condensed chromatin during apoptosis...
  17. doi Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway
    Ju Hyun Kim
    Department of Pathology, Hallym University College of Medicine, Chuncheon, Korea
    J Immunol 182:2458-66. 2009
    ..Recently, high mobility group box 1 (HMGB1) was identified as a necessary and sufficient mediator of the lethal systemic inflammation caused by sepsis...
  18. pmc HMGB1 is an endogenous immune adjuvant released by necrotic cells
    Patrizia Rovere-Querini
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit H San Raffaele Scientific Institute and Vita Salute San Raffaele University, DIBIT 3A1, Chromatin Dynamics Unit, Via Olgettina 58, 20132 Milano, Italy
    EMBO Rep 5:825-30. 2004
    ..Necrotic cells contain and release innate adjuvants; necrotic cells also release high-mobility group B1 protein (HMGB1), an abundant and conserved constituent of vertebrate nuclei...
  19. ncbi Systemic release of high mobility group box 1 protein during severe murine influenza
    Lisa M Alleva
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 181:1454-9. 2008
    ..No work to date has addressed the role of high mobility group box 1 protein (HMGB1) in influenza, the parallel being that in other severe proinflammatory cytokine syndromes (e.g...
  20. doi Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury
    Jon Cardinal
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Hepatology 50:565-74. 2009
    The nuclear protein high mobility group box 1 (HMGB1) is an important inflammatory mediator involved in the pathogenesis of liver ischemia/reperfusion (I/R) injury...
  21. pmc Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness
    Shipan Dai
    Division of Pediatric Surgery, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15207, USA
    J Biol Chem 285:4995-5002. 2010
    ..High mobility group box-1 (HMGB1) is a DNA-binding protein that is released from injured cells during inflammation...
  22. doi High-mobility group box 1 release and redox regulation accompany regeneration and remodeling of skeletal muscle
    Michela Vezzoli
    Innate Immunity and Tissue Remodeling Unit, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Antioxid Redox Signal 15:2161-74. 2011
    High-mobility group box 1 (HMGB1), a damage-associated molecular pattern (DAMP) molecules, favors tissue regeneration via recruitment and activation of leukocytes and stem cells...
  23. ncbi Hmg4, a new member of the Hmg1/2 gene family
    T Vaccari
    DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Genomics 49:247-52. 1998
    ..The members of one such family, HMG1 and HMG2, are ubiquitously expressed and facilitate the formation of nucleoprotein complexes where the DNA is ..
  24. pmc Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
    Tiziana Bonaldi
    DIBIT, San Raffaele Scientific Institute, San Raffaele University, Via Olgettina 58, 20132 Milan, Italy
    EMBO J 22:5551-60. 2003
    High Mobility Group 1 protein (HMGB1) is a chromatin component that, when leaked out by necrotic cells, triggers inflammation...
  25. pmc A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin
    Valeria V Orlova
    Experimental Immunology Branch, NCI, NIH, Bethesda, MD 20892, USA
    EMBO J 26:1129-39. 2007
    High-mobility group box 1 (HMGB1) is released extracellularly upon cell necrosis acting as a mediator in tissue injury and inflammation. However, the molecular mechanisms for the proinflammatory effect of HMGB1 are poorly understood...
  26. doi High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice
    Tatsuro Kitahara
    Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Cardiovasc Res 80:40-6. 2008
    High-mobility group box 1 (HMGB1) is a nuclear DNA-binding protein and is released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis...
  27. doi Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia
    Runkuan Yang
    Dept of Critical Care Medicine, Univ of Pittsburgh Medical School, 1055 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Regul Integr Comp Physiol 297:R362-9. 2009
    ..cells and extrahepatic macrophages release a large amount of the inflammatory cytokine high-mobility group box 1 (HMGB1) into the bile and that bile containing HMGB1 contributes to gut barrier dysfunction in experimental endotoxemia...
  28. pmc Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity
    Julie G Ledford
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 185:3884-94. 2010
    ..pneumoniae-induced DC maturation by regulating HMGB-1 cytokine activity...
  29. doi Proteome profiling suggests a pro-inflammatory role for plasma cells through release of high-mobility group box 1 protein
    Christian Vettermann
    Division of Molecular Immunology, Department of Internal Medicine, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Proteomics 11:1228-37. 2011
    ..Additionally, we discovered that the non-canonical inflammatory cytokine high-mobility group box 1 (HMG1) was released from plasma cells into the extracellular milieu...
  30. pmc High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress
    Daolin Tang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 15:2185-95. 2011
    Autophagy, the process by which cells break down spent biochemical and damaged components, plays an important role in cell survival following stress. High mobility group box 1 (HMGB1) regulates autophagy in response to oxidative stress.
  31. pmc Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1
    Asada Leelahavanichkul
    Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Kidney Int 80:1198-211. 2011
    ..Accumulation of High Mobility Group Box Protein-1 (HMGB1; a late proinflammatory cytokine released from apoptotic cells), vascular endothelial growth factor (VEGF), tumor ..
  32. pmc High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products
    Andrey Mazarati
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    Exp Neurol 232:143-8. 2011
    High-mobility group box-1 (HMGB1) is a nuclear protein with cytokine-type functions upon its extracellular release...
  33. pmc High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury
    Ulka Sachdev
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    J Vasc Surg 55:180-91. 2012
    ..We hypothesize that one of the endogenous ligands for innate immune signaling, high mobility group box 1 (HMGB1), in combination with autophagic responses to hypoxia or nutrient deprivation, plays an important role in ..
  34. pmc Heparan sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE)
    Ding Xu
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California at San Diego, La Jolla, California 92093 0687, USA
    J Biol Chem 286:41736-44. 2011
    In a proteomic search for heparan sulfate-binding proteins on monocytes, we identified HMGB1 (high mobility group protein B1)...
  35. pmc Poly(ADP-ribosyl)ation of high mobility group box 1 (HMGB1) protein enhances inhibition of efferocytosis
    Kasey Davis
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Mol Med 18:359-69. 2012
    ..High mobility group box 1 (HMGB1) protein was first described as a nuclear nonhistone DNA-binding protein, but is now known to be secreted by ..
  36. pmc Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis
    Maria Entezari
    Cardiopulmonary Toxicology, Department of Pharmaceutical Sciences, St John s University College of Pharmacy and Allied Health Professions, Queens, New York 11439, USA
    Mol Med 18:477-85. 2012
    ..High-mobility group box 1 protein (HMGB1), a ubiquitous DNA binding protein that promotes inflammatory tissue injury, is significantly elevated in CF ..
  37. pmc Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism
    Jean Marc Tadie
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    Mol Med 18:659-68. 2012
    ..that nuclear to cytosolic translocation of the proinflammatory mediator high mobility group box 1 protein (HMGB1) correlated with inhibition of AMPK activation in LPS-stimulated macrophages...
  38. pmc Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 109:7505-10. 2012
    ..reactive astrocytes can release a damage-associated molecular-pattern molecule called high-mobility-group-box-1 (HMGB1) that promotes endothelial progenitor cell (EPC)-mediated neurovascular remodeling during stroke recovery...
  39. pmc Toll-like receptor 4 and high-mobility group box 1 are critical mediators of tissue injury and survival in a mouse model for heatstroke
    Mohammed Dehbi
    Department of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia
    PLoS ONE 7:e44100. 2012
    ..We examined whether endogenous ligands released by damaged/stressed cells such as high-mobility group box 1 (HMGB1) signaling through Toll-like receptor 4 (TLR4) may play a pathogenic role in heatstroke...
  40. pmc High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice
    Nobuhide Matsuoka
    Department of Regenerative Medicine and Transplantation, Fukuoka University, Japan
    J Clin Invest 120:735-43. 2010
    ..Here, we have demonstrated that high-mobility group box 1 (HMGB1) plays a crucial role in the initial events of early loss of transplanted islets in a mouse model of diabetes...
  41. ncbi Heat shock response inhibits release of high mobility group box 1 protein induced by endotoxin in murine macrophages
    Daolin Tang
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410008, People s Republic of China
    Shock 23:434-40. 2005
    ..of this study was to evaluate the kinetic changes and the localization of high-mobility group box 1 protein (HMGB1) and to observe the effect of heat shock response (HSR) on the expression and release of HMGB1 in ..
  42. doi Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes
    Takashi Ito
    Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Arterioscler Thromb Vasc Biol 28:1825-30. 2008
    High mobility group box 1 protein (HMGB1) was identified as a mediator of endotoxin lethality...
  43. pmc High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy
    Yoko Oyama
    Department of Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Lab Invest 90:853-66. 2010
    ..The DNA-binding high-mobility group box-1 protein (HMGB1) initiates and propagates inflammation when released by activated macrophages, and functions as an 'alarm cytokine'..
  44. pmc PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia
    Katsuto Tamai
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 108:6609-14. 2011
    ..Skin grafts release high mobility group box 1 (HMGB1) in vitro and in vivo, which can mobilize the Lin(-)/PDGFRα(+) cells from bone marrow to target the engrafted ..
  45. ncbi A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, CZ 612 65 Brno, Czech Republic
    J Biol Chem 275:35699-707. 2000
    ....
  46. ncbi Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2
    L Ronfani
    DIBIT, Istituto Scientifico San Raffaele, Via Olgettina 58, Italy
    Development 128:1265-73. 2001
    High mobility group 2 protein (Hmgb2) is a member of the HMGB protein family, which includes the ubiquitous Hmgb1 and the embryo-specific Hmgb3...
  47. ncbi Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 76:994-1001. 2004
    ..macrophages to sequentially release early [tumor necrosis factor (TNF)] and late [high mobility group box 1 (HMGB1)] proinflammatory cytokines. The requirement of CD14 and mitogen-activated protein kinases [MAPK; e.g...
  48. ncbi Mechanisms of Disease: the role of high-mobility group protein 1 in the pathogenesis of inflammatory arthritis
    Weiwen Jiang
    Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Nat Clin Pract Rheumatol 3:52-8. 2007
    High-mobility group protein 1 (HMG1) is a nonhistone nuclear protein that is a prototype of a dual-function alarmin whose immune activity is dependent upon its cellular location...
  49. ncbi The mouse gene coding for high mobility group 1 protein (HMG1)
    S Ferrari
    DIBIT, San Raffaele Scientific Institute, Milano, Italy
    J Biol Chem 269:28803-8. 1994
    We have isolated an active gene encoding the mouse HMG1 protein among a multitude of cross-hybridizing sequences, which most likely are retrotransposed pseudogenes...
  50. ncbi The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13
    S Ferrari
    Dipartimento di Genetica e di Biologia dei Microrganismi, Via Celoria 26, Milan, 20133, Italy
    Genomics 35:367-71. 1996
    The human genome contains a large number of sequences related to the cDNA for High Mobility Group 1 protein (HMG1), which so far has hampered the cloning and mapping of the active HMG1 gene...
  51. ncbi The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice
    S Calogero
    DIBIT, San Raffaele Scientific Institute, Milano, Italy
    Nat Genet 22:276-80. 1999
    High mobility group 1 (HMG1) protein is an abundant component of all mammalian nuclei, and related proteins exist in all eukaryotes...
  52. ncbi Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins
    C Butteroni
    Gene Expression Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, D 69126, Germany
    J Mol Biol 304:529-40. 2000
    ..In addition, HMG-1 was found to cooperate with Oct-4 in P19 EC cells. These results provide the first evidence of a non-viral factor that enhances Oct-4 distance-dependent transactivation in stem cells...
  53. ncbi HMGB1 as a DNA-binding cytokine
    Ulf Andersson
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Stockholm, Sweden
    J Leukoc Biol 72:1084-91. 2002
    b>HMGB1 (high mobility group box chromosomal protein 1), historically known as an abundant, nonhistone architectural chromosomal protein, is extremely conserved across species...
  54. ncbi HMGB1 interacts differentially with members of the Rel family of transcription factors
    Alessandra Agresti
    DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Biochem Biophys Res Commun 302:421-6. 2003
    b>HMGB1 is an architectural factor that enhances the DNA binding affinity of several proteins. We have investigated the influence of HMGB1 on DNA binding by members of the Rel family...
  55. ncbi HMGB1, an architectural chromatin protein and extracellular signalling factor, has a spatially and temporally restricted expression pattern in mouse brain
    Stefania Guazzi
    DIBIT, San Raffaele Scientific Institute, Via Olgettina, 58, 20132 Milan, Italy
    Gene Expr Patterns 3:29-33. 2003
    b>HMGB1 is an abundant chromatin component, so far considered ubiquitous...
  56. pmc Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation
    Roberta Palumbo
    Department of Molecular Biology and Functional Genomics, San Raffaele Research Institute, Milan, Italy
    J Cell Biol 164:441-9. 2004
    High mobility group box 1 (HMGB1) is an abundant chromatin protein that acts as a cytokine when released in the extracellular milieu by necrotic and inflammatory cells...
  57. ncbi Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator
    Helena Erlandsson Harris
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
    Eur J Immunol 34:1503-12. 2004
    The intranuclear architectural protein that is termed high mobility group box chromosomal protein 1 (HMGB1) was recently identified as a potent proinflammatory mediator when present extracellularly...
  58. ncbi HMGB1 contributes to the development of acute lung injury after hemorrhage
    Jae Yeol Kim
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 288:L958-65. 2005
    High mobility group box 1 (HMGB1) is a novel late mediator of inflammatory responses that contributes to endotoxin-induced acute lung injury and sepsis-associated lethality...
  59. ncbi Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability
    Sabrina Giavara
    The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
    Curr Biol 15:68-72. 2005
    ..that belong to the high-mobility group box (HMGB) superfamily and appear to be functionally related to mammalian Hmgb1. They bind to the minor groove of double-stranded DNA in a non-sequence-specific manner and thereby influence ..
  60. pmc The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    Allan Tsung
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 201:1135-43. 2005
    High-mobility group box 1 (HMGB1) is a nuclear factor that is released extracellularly as a late mediator of lethality in sepsis as well as after necrotic, but not apoptotic, death...
  61. ncbi Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Milan, Italy
    J Immunol 174:7506-15. 2005
    High mobility group box 1 (HMGB1) is an abundant and conserved nuclear protein that is released by necrotic cells and acts in the extracellular environment as a primary proinflammatory signal...
  62. ncbi High mobility group box 1 protein interacts with multiple Toll-like receptors
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, Box C272, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 290:C917-24. 2006
    High mobility group box 1 (HMGB1), originally described as a DNA-binding protein, can also be released extracellularly and functions as a late mediator of inflammatory responses...
  63. ncbi HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers
    Shiguang Liu
    Department of Critical Care Medicine, Univ of Pittsburgh School of Medicine, 616 Scaife Hall, 3550 Terrace St, PA 15261, USA
    Am J Physiol Cell Physiol 290:C990-9. 2006
    High-mobility group box 1 (HMGB1), a cytokine-like proinflammatory protein, is secreted by activated macrophages and released by necrotic cells. We hypothesized that immunostimulated enterocytes might be another source for this mediator...
  64. ncbi Pivotal advances: high-mobility group box 1 protein--a cytokine with a role in cardiac repair
    Antonia Germani
    Laboratorio di Biologia Vascolare e Terapia Genica, Centro Cardiologico Fondazione Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    J Leukoc Biol 81:41-5. 2007
    The nuclear protein high-mobility group box 1 (HMGB1) has been largely characterized for its role in inflammation...
  65. ncbi Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury
    Allan Tsung
    Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Presbyterian Hospital F1200, Pittsburgh, PA 15213, USA
    J Leukoc Biol 81:119-28. 2007
    ..High-mobility group box 1 (HMGB1), a NF released by necrotic cells or secreted by stimulated cells, is one of a number of ligands promoting TLR4 ..
  66. ncbi Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion
    Ju Ho Youn
    Department of Microbiology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemoon Gu, Seoul 120 752, Korea
    J Immunol 177:7889-97. 2006
    The high mobility group box 1 (HMGB1) protein can be secreted by activated monocytes and macrophages and functions as a late mediator of sepsis...
  67. pmc Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1
    Daolin Tang
    Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    J Leukoc Biol 81:741-7. 2007
    High mobility group box 1 (HMGB1) can be actively secreted by macrophages/monocytes in response to exogenous and endogenous inflammatory stimuli (such as bacterial endotoxin, TNF-alpha, IL-1, and IFN-gamma) or passively released by ..
  68. ncbi Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    Jane Tian
    Inflammation and Autoimmune Group, Research Department, MedImmune, Gaithersburg, Maryland 20878, USA
    Nat Immunol 8:487-96. 2007
    ..Here we show that HMGB1, a nuclear DNA-binding protein released from necrotic cells, was an essential component of DNA-containing immune ..
  69. ncbi The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid
    Weiwen Jiang
    Division of Rheumatology and Immunology, Department of Medicine, Duke University, and Medical Research Services, Durham Veterans Affairs Medical Center, NC 27710, USA
    J Immunol 178:6495-503. 2007
    High-mobility group protein 1 (HMGB1) is a nonhistone nuclear protein whose function depends on cellular location...
  70. ncbi HMGB1 modulates inflammatory responses in LPS-activated macrophages
    M El Gazzar
    Deparment of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Inflamm Res 56:162-7. 2007
    As a late mediator of inflammation, high mobility group box 1 protein (HMGB1) amplifies the inflammatory responses to tissue injury and infection by inducing and extending the production of proinflammaory cytokines...
  71. pmc A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA
    Stanimir Ivanov
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    Blood 110:1970-81. 2007
    ..However, the mechanism of TLR9 activation by CpG-DNA remains elusive. Here we have identified HMGB1 as a CpG-ODN-binding protein...
  72. ncbi Essential roles of high-mobility group box 1 in the development of murine colitis and colitis-associated cancer
    Shin Maeda
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Chiyoda ku, Tokyo 100 0005, Japan
    Biochem Biophys Res Commun 360:394-400. 2007
    High-mobility group box 1 (HMGB1) is a nuclear factor released extracellularly as a proinflammatory cytokine...
  73. ncbi Multiple effects of high mobility group box protein 1 in skeletal muscle regeneration
    Roberta De Mori
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Arterioscler Thromb Vasc Biol 27:2377-83. 2007
    High mobility group box 1 protein (HMGB1) is a cytokine released by necrotic and inflammatory cells in response to injury. We examined the role of HMGB1 in skeletal muscle regeneration after hindlimb ischemia.
  74. pmc HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling
    Allan Tsung
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 204:2913-23. 2007
    ..The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from ischemic cells...
  75. doi High-mobility group box-1 in ischemia-reperfusion injury of the heart
    Martin Andrassy
    Department of Medicine III, University of Heidelberg, Heidelberg, Germany
    Circulation 117:3216-26. 2008
    High-mobility group box-1 (HMGB1) is a nuclear factor released by necrotic cells and by activated immune cells. HMGB1 signals via members of the toll-like receptor family and the receptor for advanced glycation end products (RAGE)...
  76. pmc Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein
    Hirotaka Kazama
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 631101, USA
    Immunity 29:21-32. 2008
    ..ROS oxidized the potential danger signal high-mobility group box-1 protein (HMGB1) released from dying cells and thereby neutralized its stimulatory activity...
  77. pmc High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage
    Sabine S Lange
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 105:10320-5. 2008
    b>High mobility group protein B1 (HMGB1) is a multifunctional protein with roles in chromatin structure, transcriptional regulation, V(D)J recombination, and inflammation...
  78. doi Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain
    Yasushi Enokido
    Department of Neuropathology, Medical Research Institute and 21st Century Center of Excellence Program COE for Brain Integration and Its Disorders, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Biochem Biophys Res Commun 376:128-33. 2008
    b>HMGB1 is an evolutionarily conserved non-histone chromatin-associated protein with key roles in maintenance of nuclear homeostasis; however, the function of HMGB1 in the brain remains largely unknown...
  79. pmc Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages
    Xianghong Zhang
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 181:5015-23. 2008
    The chromatin-binding factor high-mobility group box 1 (HMGB1) functions as a proinflammatory cytokine and late mediator of mortality in murine endotoxemia...
  80. pmc Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam and daggerCenter for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Shock 31:280-4. 2009
    ..These data indicate that HMGB-1 induces release of cytokines, activation of coagulation, and neutrophil recruitment in vivo via a mechanism that at least in part depends on TLR-4 and RAGE...
  81. doi HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism
    Young Joo Oh
    Department of Microbiology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    J Immunol 182:5800-9. 2009
    High-mobility group box 1 protein (HMGB1) has been studied as a key mediator of inflammatory diseases, including sepsis. Regulating secretion is important in the control of HMGB1-mediated inflammation...
  82. doi Requirement of HMGB1 for stromal cell-derived factor-1/CXCL12-dependent migration of macrophages and dendritic cells
    Lara Campana
    Innate Immunity and Tissue Remodeling Unit, H San Raffaele Scientific Institute, Milano 20132, Italy
    J Leukoc Biol 86:609-15. 2009
    b>HMGB1 finely tunes the function of DCs, thus influencing their maturation program and eventually the establishment of adaptive, T cell-dependent immune responses...
  83. pmc NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways
    Stephen B Willingham
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 183:2008-15. 2009
    ..are macrophage/monocyte necrosis, release of the proinflammatory factor high-mobility group box 1 protein (HMGB1), and induction of the cytokine IL-1...
  84. doi The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway
    Hu Xu
    Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada
    J Immunol 184:1492-8. 2010
    High mobility group box 1 (HMGB1) is an alarmin actively secreted by immune cells and passively released by necrotic nonimmune cells...
  85. pmc Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]
    Marianna Penzo
    Vita Salute San Raffaele University, School of Medicine, San Raffaele Scientific Institute, Milano, Italy
    J Immunol 184:4497-509. 2010
    ..Moreover, IKKalpha can attenuate IKKbeta-initiated inflammatory responses. High mobility group box 1 (HMGB1), a chromatin protein, is an extracellular signal of tissue damage-attracting cells in inflammation, tissue ..
  86. pmc High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia
    Jianhua Qiu
    Department of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02129, USA
    Stroke 41:2077-82. 2010
    b>HMGB1 is a nuclear protein and an alarmin that signals cell damage in response to injury...
  87. doi HMGB1: the missing link between diabetes mellitus and heart failure
    H Christian Volz
    Department of Medicine III, University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    Basic Res Cardiol 105:805-20. 2010
    ..glucose treatment of isolated cardiac fibroblasts, macrophages and cardiomyocytes led to a sustained induction of HMGB1 on the RNA and protein level followed by increased NF-κB binding activity with consecutively sustained TNF-α and ..
  88. doi High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response
    Lihua Duan
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Lab Invest 91:43-53. 2011
    Previously, we reported that extracellular high-mobility group box 1 (HMGB1) functions as an innate alarmin implicated in cardiac allograft acute rejection...
  89. pmc Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia
    Mohamed Lamkanfi
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    J Immunol 185:4385-92. 2010
    ..Reduced serum high mobility group box 1 (HMGB1) levels in caspase 1-deficient mice correlated with their resistance to LPS...
  90. pmc Endogenous HMGB1 regulates autophagy
    Daolin Tang
    Damage Associated Molecular Pattern Molecule Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Cell Biol 190:881-92. 2010
    ..Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a ..
  91. pmc Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo
    Noureddine Loukili
    Department of Intensive Care Medicine, University Hospital Center and Faculty of Biology and Medicine, 1011 Lausanne, Switzerland
    Cardiovasc Res 89:586-94. 2011
    High-mobility group box 1 (HMGB1) is a nuclear protein actively secreted by immune cells and passively released by necrotic cells that initiates pro-inflammatory signalling through binding to the receptor for advance glycation end-..
  92. doi High-mobility group box-1 mediates toll-like receptor 4-dependent angiogenesis
    Qing Lin
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 S Xianlie Rd, Guangzhou 510060, China
    Arterioscler Thromb Vasc Biol 31:1024-32. 2011
    ..However, the impact of TLRs on angiogenesis is incompletely understood. In this study, we determined the involvement of TLRs in angiogenesis...
  93. pmc High-mobility group box 1 is essential for mitochondrial quality control
    Daolin Tang
    Department of Surgery, G 27A Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    Cell Metab 13:701-11. 2011
    ..High-mobility group box 1 (HMGB1), an evolutionarily conserved chromatin-associated protein which maintains nuclear homeostasis, is also a critical ..
  94. pmc Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models
    Hanna Schierbeck
    Department of Women s and Children s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Mol Med 17:1039-44. 2011
    High mobility group box chromosomal protein 1 (HMGB1) is a DNA-binding nuclear protein that can be released from dying cells and activated myeloid cells. Extracellularly, HMGB1 promotes inflammation...
  95. doi HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion
    Zhaoliang Su
    Department of Immunology, Jiangsu University, Zhenjiang, PR China
    Eur J Immunol 41:3586-95. 2011
    High-mobility group box 1 (HMGB1), a non-histone nuclear protein, has been implicated in cardiovascular diseases...
  96. pmc High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases
    Wei Yan
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hepatology 55:1863-75. 2012
    ..the mechanism by which the nuclear-damage-associated molecular pattern molecule, high-mobility group box 1 (HMGB1), released under hypoxic stress, can induce an inflammatory response to promote invasion and metastasis in ..
  97. doi HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences and Istituto Interuniversitario di Miologia, University of Perugia, Via del Giochetto, 06122, Perugia, Italy
    J Cell Sci 125:1440-54. 2012
    ..myoblasts by binding to specific recognition sites in the Pax7 promoter, and that high-mobility group box 1 (HMGB1)-receptor for advanced glycation end-products (RAGE) signaling was required for myogenin induction and myogenin-..
  98. pmc HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
    Milena Schiraldi
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    J Exp Med 209:551-63. 2012
    After tissue damage, inflammatory cells infiltrate the tissue and release proinflammatory cytokines. HMGB1 (high mobility group box 1), a nuclear protein released by necrotic and severely stressed cells, promotes cytokine release via its ..
  99. doi Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway
    Yongwei Yao
    Division of Cardiology, Department of Medicine, the Affiliated People s Hospital of Jiangsu University, No 8 DianLi Road, Zhenjiang, 212002, Jiangsu Province, People s Republic of China
    Basic Res Cardiol 107:267. 2012
    ..The aim of present study is to investigate the role of high-mobility group box 1 (HMGB1) in DOX-induced myocardial injury, and signal pathway involved in regulation of HMGB1 expression in cardiomyocytes ..
  100. doi High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4
    Yuji Nadatani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Pathol 181:98-110. 2012
    Release of high mobility group box 1 (HMGB1) from damaged cells, which is involved in many types of tissue injuries, activates inflammatory pathways by stimulating multiple receptors, including Toll-like receptor 2 (TLR2), TLR4, and ..
  101. pmc Novel role of PKR in inflammasome activation and HMGB1 release
    Ben Lu
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 488:670-4. 2012
    ..of caspase activation-dependent cytokines, including interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1)...

Research Grants5

  1. Regulation of the Ocular Immune Response by Retinal Pigment Epithelium
    Hui Shao; Fiscal Year: 2007
    ..The results of our studies will provide new insights into the pathogenesis of uveitis. [unreadable] [unreadable] [unreadable]..
  2. GENERAL CLINICAL RESEARCH CENTER
    Kevin J Tracey; Fiscal Year: 2010
    ..This proposal seeks continued funding for the Feinstein GCRC by NCRR. ..
  3. The role of costimulatory molecules in uveitis
    Hui Shao; Fiscal Year: 2011
    ..These studies should provide insights into the pathogenic mechanism leading to disease progression and help in the development of supplementary therapies for this devastating disease. ..
  4. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  5. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....