Heyl

Summary

Gene Symbol: Heyl
Description: hairy/enhancer-of-split related with YRPW motif-like
Alias: Hey3, Hrt3, bHLHb33, hesr3, hairy/enhancer-of-split related with YRPW motif-like protein, HRT-3, hairy and enhance of split related 3, hairy and enhancer of split-related protein 3, hairy-related transcription factor 3, mHRT3
Species: mouse

Top Publications

  1. pmc RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
    Yufeng Dong
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 137:1461-71. 2010
  2. pmc Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice
    Hyun Woo Jeong
    Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea
    J Clin Invest 119:3290-300. 2009
  3. pmc HeyL promotes neuronal differentiation of neural progenitor cells
    Ali Jalali
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Neurosci Res 89:299-309. 2011
  4. pmc Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers
    So ichiro Fukada
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Development 138:4609-19. 2011
  5. pmc Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
    Matthew J Hilton
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:306-14. 2008
  6. ncbi Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition
    Andreas Fischer
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Wurzburg, Germany
    Circ Res 100:856-63. 2007
  7. pmc Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts
    Andreas Fischer
    Theodor Boveri Institute, Physiological Chemistry I, University of Wuerzburg, Germany
    Mol Cell Biol 25:8960-70. 2005
  8. pmc Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1
    Karin Schuster-Gossler
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Genetics 202:1119-33. 2016
  9. pmc Notch activation induces endothelial cell senescence and pro-inflammatory response: implication of Notch signaling in atherosclerosis
    Zhao Jun Liu
    Department of Surgery, University of Miami, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Atherosclerosis 225:296-303. 2012
  10. pmc Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice
    Sun Kyoung Im
    School of Biological Science, College of Natural Sciences, Seoul National University, Seoul, South Korea
    PLoS ONE 8:e58511. 2013

Scientific Experts

  • Steven Raft
  • Kenro Kusumi
  • Jay L Vivian
  • So ichiro Fukada
  • Karin Schuster-Gossler
  • Abhishek Mukhopadhyay
  • Manfred Gessler
  • Paven K Aujla
  • Julia Heisig
  • Lori T Raetzman
  • Sun Kyoung Im
  • Andreas Fischer
  • Leah B Goldberg
  • Xiaolin Tu
  • Hyun Woo Jeong
  • Ryoichiro Kageyama
  • Matthew J Hilton
  • Valeria Di Giovanni
  • Shurei Sugita
  • Liangfeng Han
  • C Leimeister
  • Thomas Xavier Garcia
  • Guillermo Luxan
  • Megan Rowton
  • Zhao Jun Liu
  • Ali Jalali
  • Toshinao Oyama
  • Tyler B Moran
  • Kouta Kanno
  • Jessica N Copeland
  • Tomoko Tateya
  • Young Yun Kong
  • Raphael Kopan
  • Yufeng Dong
  • Fanxin Long
  • Hiroki Kokubo
  • Aurélie Jory
  • O Nakagawa
  • Lan Yi
  • Marie Isabelle Garcia
  • Yiwei Zong
  • Maria L Golson
  • Toshinori Hayashi
  • Frances A High
  • Linghong Chen
  • C Steidl
  • M Gessler
  • Masayoshi Onishi
  • Ryosuke Tsunematsu
  • Cornelia Leimeister
  • Song Ho Chang
  • Yuki Taniguchi
  • Hirotaka Chikuda
  • Caitlin Schaefer
  • Pawan Puri
  • Manabu Kawata
  • Yoko Hosaka
  • Keita Okada
  • Tomotake Okuma
  • Haruhiko Akiyama
  • Kenneth A Walker
  • Fumiko Yano
  • Shinsuke Ohba
  • Daniel Bushnell
  • Ung Il Chung
  • Taku Saito
  • Sakae Tanaka
  • Yoshifumi Mori
  • Hiroshi Kawaguchi
  • Carlton M Bates
  • Daisuke Mori
  • Sunder Sims-Lucas
  • Shuji Taketomi
  • Hiroshi Kobayashi
  • Scott Kominsky
  • Nguyen K Nguyen
  • Alan Rein
  • Pedram Argani
  • Goran Landberg
  • Adam Diehl
  • Preethi Korangath
  • Soonweng Cho
  • Lionel Feigenbaum
  • Jaspreet Kaur Farmaha
  • Weiwen Teo
  • Saraswati Sukumar
  • David L Huso
  • Sean Kow
  • Marie Claude Hofmann
  • Liwen Xu

Detail Information

Publications48

  1. pmc RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
    Yufeng Dong
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 137:1461-71. 2010
    ..Finally, Hes1 was identified as an RBPjkappa-dependent Notch target gene important for MPC maintenance and the suppression of in vitro chondrogenesis...
  2. pmc Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice
    Hyun Woo Jeong
    Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea
    J Clin Invest 119:3290-300. 2009
    ..Our data demonstrate that Notch signaling is required for the development of the mammalian renal collecting duct and principal cell differentiation and indicate that pathway dysregulation may contribute to distal renal tubular disorders...
  3. pmc HeyL promotes neuronal differentiation of neural progenitor cells
    Ali Jalali
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Neurosci Res 89:299-309. 2011
    ..We found that HeyL, contrary to the classic function of Hes and Hey factors, promotes neuronal differentiation of neural progenitor ..
  4. pmc Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers
    So ichiro Fukada
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Development 138:4609-19. 2011
    ..We show that Hesr1 (Hey1) and Hesr3 (Heyl) (which are known Notch target genes) are expressed simultaneously in skeletal muscle only in satellite ..
  5. pmc Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
    Matthew J Hilton
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:306-14. 2008
    ..Thus, mesenchymal progenitors may be expanded in vitro by activating the Notch pathway, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway...
  6. ncbi Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition
    Andreas Fischer
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Wurzburg, Germany
    Circ Res 100:856-63. 2007
    ..Here we report that combined inactivation of Hey1 and HeyL, two primary target genes of Notch, causes severe heart malformations, including membranous ventricular septal ..
  7. pmc Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts
    Andreas Fischer
    Theodor Boveri Institute, Physiological Chemistry I, University of Wuerzburg, Germany
    Mol Cell Biol 25:8960-70. 2005
    ..In addition, the promoter activity of the GATA4/6 target gene ANF was inhibited by Hey1, Hey2, and HeyL. Protein interaction and mutation analyses suggest that repression is due to direct binding of Hey proteins to ..
  8. pmc Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1
    Karin Schuster-Gossler
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Genetics 202:1119-33. 2016
    ..In conclusion, the structural integrity of each individual EGF repeat in the extracellular domain of DLL1 is necessary for full DLL1 activity, and certain mutations in Dll1 might contribute to spondylocostal dysostosis in humans. ..
  9. pmc Notch activation induces endothelial cell senescence and pro-inflammatory response: implication of Notch signaling in atherosclerosis
    Zhao Jun Liu
    Department of Surgery, University of Miami, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Atherosclerosis 225:296-303. 2012
    ..Notch signaling plays pivotal roles in the pathogenesis of vascular disease. However, little is known about its role in atherosclerosis. We sought to investigate the potential involvement of the Notch signaling in atherosclerosis...
  10. pmc Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice
    Sun Kyoung Im
    School of Biological Science, College of Natural Sciences, Seoul National University, Seoul, South Korea
    PLoS ONE 8:e58511. 2013
    ..These results demonstrate that Snx5 is necessary for the differentiation of alveolar epithelial type I cells, which may underlie the adaptation to air breathing at birth...
  11. pmc Notch/Rbpjκ signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons
    Paven K Aujla
    University of Illinois at Urbana Champaign, 407 South Goodwin Avenue, Urbana, IL 61801, USA
    Development 140:3511-21. 2013
    ..Taken together, our results demonstrate that Notch/Rbpjκ signaling regulates the generation and differentiation of Arc neurons, which contribute to homeostatic regulation of body size. ..
  12. doi Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis
    Megan Rowton
    School of Life Sciences, Arizona State University, Tempe, Arizona
    Dev Dyn 242:1332-44. 2013
    ..However, the target genes downstream of the transcription factor PARAXIS remain poorly described...
  13. pmc Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2
    Shurei Sugita
    Sensory and Motor System Medicine
    Proc Natl Acad Sci U S A 112:3080-5. 2015
    ..Our findings have contributed to further understanding of the molecular pathophysiology of OA, and may provide the basis for development of novel treatments for joint disorders. ..
  14. pmc Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear
    Steven Raft
    Section on Sensory Cell Regeneration and Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Dev Biol 390:51-67. 2014
    ..We propose that developmental dysplasias described here are a gene dose-sensitive cause of the vestibular dysfunction observed in EphB-Efnb2 signaling-deficient mice. ..
  15. pmc Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors
    Valeria Di Giovanni
    Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA
    Dev Biol 400:82-93. 2015
    ..Thus, Fgfr1 and Fgfr2 have synergistic roles in maintaining nephron progenitors; furthermore, Fgfr signaling in nephron progenitors appears to be mediated predominantly by Frs2α. ..
  16. pmc The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk
    Liangfeng Han
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Cancer Res 74:6509-18. 2014
    ..Here, we present evidence of crosstalk between these two pathways through HEYL. HEYL, a basic helix-loop-helix transcription factor and a direct target of Notch signaling, is specifically ..
  17. pmc RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche
    Thomas Xavier Garcia
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Unit 1105, PO Box 301402, Houston, TX 77230 1402, USA Department of Comparative Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Development 141:4468-78. 2014
    ....
  18. doi Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy
    Guillermo Luxan
    Program of Cardiovascular Developmental Biology, Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    Nat Med 19:193-201. 2013
    ..These results implicate NOTCH signaling in LVNC and indicate that MIB1 mutations arrest chamber myocardium development, preventing trabecular maturation and compaction...
  19. pmc Numb deletion in POMC-expressing cells impairs pituitary intermediate lobe cell adhesion, progenitor cell localization, and neuro-intermediate lobe boundary formation
    Tyler B Moran
    University of Illinois at Urbana Champaign, 407 South Goodwin Avenue, Urbana, Illinois 61801, USA
    Mol Endocrinol 25:117-27. 2011
    ..Unexpectedly, Notch activity appears normal in conditional knockout mice. Thus, Numb is critical for maintaining cell-cell interactions in the pituitary intermediate lobe that are essential for proper cell placement...
  20. doi Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo
    Toshinao Oyama
    Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Development 138:5235-46. 2011
    ..These results indicate that engagement of Mam is essential for Notch signaling, and that the three Mam isoforms have distinct roles in vivo...
  21. pmc Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1
    Xiaolin Tu
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 8:e1002577. 2012
    ..Moreover, mice deficient in Hey1 and HeyL, two target genes of Notch-RBPjk signaling, exhibited high bone mass...
  22. pmc Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors
    Julia Heisig
    Developmental Biochemistry, Theodor Boveri Institute, Biocenter, University of Wuerzburg, Wuerzburg, Germany
    PLoS Genet 8:e1002728. 2012
    ..The striking overlap of cardiac defects in HEY2 and combined HEY1/HEYL knockout mice suggested that all three HEY genes fulfill overlapping function in target cells...
  23. pmc Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis
    Leah B Goldberg
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Dev Biol 358:23-32. 2011
    ..Taken together, these findings show that Notch signaling is sufficient to prevent corticotrope and melanotrope differentiation, resulting in dysregulation of the HPA axis...
  24. pmc Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac
    Jessica N Copeland
    Department of Pathology and Laboratory Medicine and Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    BMC Dev Biol 11:12. 2011
    ..To further understand the role of Notch signaling during endothelial differentiation and the genes regulated by this pathway, both loss-of-function and gain-of-function approaches were analyzed in vivo...
  25. doi Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development
    Tomoko Tateya
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Dev Biol 352:329-40. 2011
    ....
  26. doi Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats
    Kouta Kanno
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan
    J Neurosci Res 89:562-75. 2011
    ..Other members of the HESR (HEY) family, including HESR2 (HEY2) and 3 (HEYL), have similar DNA-binding domains...
  27. doi Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite
    Aurélie Jory
    Stem Cells and Development, Department of Developmental Biology Pasteur Institute, Centre National de la Recherche Scientifique CNRS URA 2578, 75724 Paris Cedex 15, France
    Stem Cells 27:2769-80. 2009
    ..Thus, we propose that Numb can regulate the self-renewal of dermal and muscle progenitors during a lineage progression...
  28. ncbi Segmental expression of Notch and Hairy genes in nephrogenesis
    Linghong Chen
    Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 W 168th St, New York, NY 10032, USA
    Am J Physiol Renal Physiol 288:F939-52. 2005
    ..We found that among all of Notch downstream Hairy genes, only Hes1, Hes5, Hey1, and HeyL were expressed in a segment-specific manner in early nephrons and their expression pattern changed dynamically ..
  29. ncbi HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments
    O Nakagawa
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
    Dev Biol 216:72-84. 1999
    ..Here, we describe a new subclass of bHLH proteins, HRT1 (Hairy-related transcription factor 1), HRT2, and HRT3, that share high homology with the Hairy family of proteins yet have characteristics that are distinct from those ..
  30. ncbi Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family
    C Steidl
    Physiologische Chemie I, Biozentrum der Universität Würzburg, Am Hubland, Wurzburg, 97074, Germany
    Genomics 66:195-203. 2000
    ..factor genes from mouse and human (hairy and Enhancer-of-split related with YRPW motif; HEY1, HEY2, and HEYL). All three HEY genes have a similar genomic structure with five exons...
  31. pmc The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function
    B A Firulli
    Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Biol Chem 275:33567-73. 2000
    ..Taken together, these results show that dHAND and eHAND can form homo- and heterodimer combinations with multiple bHLH partners and that this broad dimerization profile reflects the mechanisms by which HAND genes regulate transcription...
  32. ncbi Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos
    C Leimeister
    Institute of Physiological Chemistry I, Theodor Boveri Institute Biocenter, University of Wuerzburg, Am Hubland, D 97074, Wuerzburg, Germany
    Mech Dev 98:175-8. 2000
    ..Here we report the embryonic expression of the hairy-related basic helix-loop-helix gene HeyL in wild-type and Notch pathway mutant mice...
  33. pmc Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling
    O Nakagawa
    Departments of Molecular Biology and Pediatrics, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Proc Natl Acad Sci U S A 97:13655-60. 2000
    ..These findings identify HRT genes as downstream targets for Notch signaling and reveal a negative autoregulatory loop whereby HRT proteins repress their own expression through interference with Notch signaling...
  34. ncbi The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina
    T Satow
    Institute for Virus Research, Kyoto University, and Department of Neurosurgery, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    J Neurosci 21:1265-73. 2001
    ..Interestingly, hesr2 but not hesr1 or hesr3 promoted gliogenesis while inhibiting rod genesis without affecting cell proliferation or death, suggesting that ..
  35. ncbi Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development
    Cornelia Leimeister
    Theodor Boveri Institute, Biozentrum, Physiological Chemistry I, University of Wuerzburg, Am Hubland, 97074, Wuerzburg, Germany
    Gene Expr Patterns 3:595-8. 2003
    ..Our results point to a Lfng-dependent role for Notch signalling in the development of nephron segments, especially the proximal tubules...
  36. ncbi Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
    Ryosuke Tsunematsu
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Biol Chem 279:9417-23. 2004
    ..Expression of Notch1, -2, or -3 or of cyclin E was unaffected in Fbw7(-/-) embryos. Mammalian Fbw7 thus appears to play an indispensable role in negative regulation of the Notch4-Hey1 pathway and is required for vascular development...
  37. ncbi Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b
    Masayoshi Onishi
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Genomics 83:647-57. 2004
    ..Dot matrix and phylogenetic tree analyses demonstrated that multiple rounds of intrachromosomal gene conversion between the two loci occurred in each species independently...
  38. ncbi Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes
    Kenro Kusumi
    Divisions of Human Genetics and Orthopaedic Surgery, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Genesis 39:115-21. 2004
    ..the Dll3(pu) mutation has different effects on the expression of cycling (Lfng and Hes7) and stage-specific genes (Hey3 and Mesp2)...
  39. ncbi Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis
    C Leimeister
    Institute of Physiological Chemistry I, Theodor Boveri Institute Biocenter, University of Wuerzburg, Am Hubland, D 97074, Wuerzburg, Germany
    Mech Dev 85:173-7. 1999
    ..The diversity of expression patterns implies unique functions in neurogenesis, somitogenesis and organogenesis...
  40. pmc Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants
    Karin Schuster-Gossler
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, D 30625 Lower Saxony, Germany
    Proc Natl Acad Sci U S A 104:537-42. 2007
    ....
  41. pmc An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation
    Frances A High
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:353-63. 2007
    ..These results provide a molecular and cellular framework for understanding the role of Notch signaling in the etiology of congenital heart disease...
  42. pmc Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea
    Toshinori Hayashi
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology HNS, Box 357923, USA
    Dev Biol 316:87-99. 2008
    ..This treatment also reduces Hesr1 and Hesr2 expression by as much as 80%. These results support the hypothesis that Hesr1 and Hesr2 are the downstream mediators of the prosensory function of Notch in early cochlear development...
  43. pmc Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development
    Karin Schuster-Gossler
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Carl Neuberg Str, 1, D 30625, Germany
    BMC Dev Biol 9:6. 2009
    ..Whether the context-dependent effects of Notch receptor glycosylation by FNG reflect different requirements of distinct developmental processes for O-fucosylation by POFUT1 is unclear...
  44. doi LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine
    Marie Isabelle Garcia
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Faculty of Medicine, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    Dev Biol 331:58-67. 2009
    ..Together, our data identify LGR5 as a negative regulator of the Wnt pathway in the developing intestine...
  45. pmc Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas
    Maria L Golson
    Department of Genetics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mech Dev 126:687-99. 2009
    ..Expression of the Notch modifier Manic Fringe (Mfng) is limited to endocrine precursors, providing a possible explanation for the inhibition of Notch signaling by Jag1 during mid-gestation embryonic pancreas development...
  46. pmc HeyL regulates the number of TrkC neurons in dorsal root ganglia
    Abhishek Mukhopadhyay
    Department of Neurology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611, USA
    Dev Biol 334:142-51. 2009
    The basic-helix-loop-helix transcription factor HeyL is expressed at high levels by neural crest progenitor cells (NCPs) that give rise to neurons and glia in dorsal root ganglia (DRG)...
  47. pmc Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung
    Lan Yi
    Laboratory of Genetics, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Dev Dyn 238:123-37. 2009
    ..This model also represents our findings on the genetic relationship between FGF9 and sonic hedgehog (SHH) in the establishment of airway SMC pattern...
  48. pmc Notch signaling controls liver development by regulating biliary differentiation
    Yiwei Zong
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 136:1727-39. 2009
    ..These results reconcile previous conflicting reports about the role of Notch during liver development and suggest that Notch acts by coordinating biliary differentiation and morphogenesis...

Research Grants1

  1. Phenotypic screen in mouse embryonic for TGF-beta signaling mutations
    JAY VIVIAN; Fiscal Year: 2007
    ..Cell-based mutation screening strategies as developed in this proposal can be applied to any active biochemical pathway in mouse ES cells, to generate mouse lines for analysis in vivo. [unreadable] [unreadable] [unreadable]..