heme oxygenase 1

Summary

Gene Symbol: heme oxygenase 1
Description: heme oxygenase 1
Alias: D8Wsu38e, HO-1, HO1, Hemox, Hmox, Hsp32, heme oxygenase 1, P32 protein, heme oxygenase (decycling) 1, hemoxygenase
Species: mouse

Top Publications

  1. pmc Overexpression of heme oxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice
    Halina Was
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Am J Pathol 169:2181-98. 2006
  2. ncbi Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
    Ana Pamplona
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Nat Med 13:703-10. 2007
  3. pmc Heme oxygenase-1 affords protection against noncerebral forms of severe malaria
    Elsa Seixas
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Proc Natl Acad Sci U S A 106:15837-42. 2009
  4. ncbi Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress
    Srinivasa R Datla
    Bernard O Brien Institute of Microsurgery, University of Melbourne, Victoria, Australia
    Hypertension 50:636-42. 2007
  5. pmc Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761) neuroprotection
    Z A Shah
    Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA
    Neuroscience 180:248-55. 2011
  6. ncbi Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress
    Qing Lin
    Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 282:20621-33. 2007
  7. ncbi Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancer
    J Alam
    Department of Molecular Genetics, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    J Biol Chem 270:11977-84. 1995
  8. ncbi Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells
    Subbiah Pugazhenthi
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, P O Box 6511, Mail Stop 8106, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 293:E645-55. 2007
  9. pmc The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice
    Stephen J Peterson
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Lipid Res 50:1293-304. 2009
  10. doi Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract
    Jia Shiong Chen
    Institute of Pharmacology, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    Atherosclerosis 214:301-9. 2011

Research Grants

  1. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010
  2. Karl A Nath; Fiscal Year: 2016
  3. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2008
  4. HEMEOXYGENASE1--REGULATION AND FUNCTION AFTER HYPEROXIA
    PATTY LEE; Fiscal Year: 2002
  5. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
  6. PRESERVATION AND CARDIAC TRANSPLANT VASCULOPATHY
    David Pinsky; Fiscal Year: 2003
  7. BIOLOGY AND CONTROL OF LYME DISEASE BORRELIA
    Alan Barbour; Fiscal Year: 2004
  8. LEUKOREGULATION BY CD39 IN LUNG ISCHEMIA AND INFLAMMATI*
    David Pinsky; Fiscal Year: 2004
  9. THROMBOREGULATORY ROLE OF CD39 (ECTOADPASE) IN STROKE
    David Pinsky; Fiscal Year: 2004
  10. LEUKOCYTE ADHESION RECEPTORS AND THROMBOSIS IN STROKE
    David Pinsky; Fiscal Year: 2006

Detail Information

Publications170 found, 100 shown here

  1. pmc Overexpression of heme oxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice
    Halina Was
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Am J Pathol 169:2181-98. 2006
    ....
  2. ncbi Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
    Ana Pamplona
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Nat Med 13:703-10. 2007
    ..These effects were mediated by the binding of CO to hemoglobin, preventing hemoglobin oxidation and the generation of free heme, a molecule that triggers ECM pathogenesis...
  3. pmc Heme oxygenase-1 affords protection against noncerebral forms of severe malaria
    Elsa Seixas
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Proc Natl Acad Sci U S A 106:15837-42. 2009
    ..In conclusion, we describe a mechanism of host defense against Plasmodium infection, based on tissue cytoprotection against free heme and limiting disease severity irrespectively of parasite burden...
  4. ncbi Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress
    Srinivasa R Datla
    Bernard O Brien Institute of Microsurgery, University of Melbourne, Victoria, Australia
    Hypertension 50:636-42. 2007
    ..Thus, systemic expression of HO-1 suppresses NADPH oxidase activity by mechanisms at least partly mediated by the bile pigment bilirubin, thereby reducing oxidative stress...
  5. pmc Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761) neuroprotection
    Z A Shah
    Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA
    Neuroscience 180:248-55. 2011
    ..B (GB), and Terpene Free Material (TFM)] could provide neuroprotection in ischemic conditions through heme oxygenase 1 (HO1)...
  6. ncbi Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress
    Qing Lin
    Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 282:20621-33. 2007
    ..We speculate that nuclear localization of HO-1 protein may serve to up-regulate genes that promote cytoprotection against oxidative stress...
  7. ncbi Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancer
    J Alam
    Department of Molecular Genetics, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    J Biol Chem 270:11977-84. 1995
    ..Induction by H2O2 was unaffected by the kinase inhibitors, but completely abolished by N-acetylcysteine. Heme-dependent induction was not significantly affected by any of these chemicals...
  8. ncbi Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells
    Subbiah Pugazhenthi
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, P O Box 6511, Mail Stop 8106, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 293:E645-55. 2007
    ..Our observations suggest that demethoxy curcuminoids could be used to induce a cellular defense mechanism in beta-cells under conditions of stress as seen in diabetes...
  9. pmc The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice
    Stephen J Peterson
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Lipid Res 50:1293-304. 2009
    ..The anti-obesity effects of L-4F are manifested by a decrease in visceral fat content with reciprocal increases in adiponectin, pAMPK, pAKT, and phosphorylation of insulin receptors with improved insulin sensitivity...
  10. doi Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract
    Jia Shiong Chen
    Institute of Pharmacology, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    Atherosclerosis 214:301-9. 2011
    ..GBE was recently suggested as a heme oxygenase (HO)-1 inducer. The role of HO-1 in anti-atherogenesis and related vascular protective effects of GBE awaited further clarification...
  11. doi Anti-inflammatory mechanism of ginsenoside Rh1 in lipopolysaccharide-stimulated microglia: critical role of the protein kinase A pathway and hemeoxygenase-1 expression
    Ji Sun Jung
    Department of Molecular Medicine and Tissue Injury Defense Research Center, Ewha Womans University Medical School, Seoul, Korea
    J Neurochem 115:1668-80. 2010
    ..Through this study, we have demonstrated that protein kinase A and its downstream effector, HO-1, play a critical role in the anti-inflammatory mechanism of Rh1 by modulating pro- and anti-inflammatory molecules in activated microglia...
  12. pmc Fractalkine attenuates excito-neurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expression
    Mariko Noda
    Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    J Biol Chem 286:2308-19. 2011
    ..These results suggest that sFKN secreted from glutamate-damaged neurons provides both phagocytotic and neuroprotective signals...
  13. doi After vascular injury, heme oxygenase-1/carbon monoxide enhances re-endothelialization via promoting mobilization of circulating endothelial progenitor cells
    H H Lin
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Thromb Haemost 7:1401-8. 2009
    ..Heme oxygenase-1 (HO-1), a heme degradation enzyme with multiple vasoprotective functions, is systemically induced in pathophysiological states associated with oxidative stress...
  14. doi Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions
    Sang Choel Lee
    Department of Internal Medicine, Kwandong University, Goyang, Gyeonggi Do, Korea
    Kidney Int 76:838-48. 2009
    ..Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions...
  15. doi Heme oxygenase-1 protects against steatohepatitis in both cultured hepatocytes and mice
    Jun Yu
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Gastroenterology 138:694-704, 704.e1. 2010
    ..Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced tissue injury. We investigated the role of HO-1 in nutritional steatohepatitis in vitro and in vivo...
  16. doi Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice
    Evie H Carchman
    VA Pittsburgh Healthcare System, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hepatology 53:2053-62. 2011
    ..LPS induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), in part, via HO-dependent signaling. Moreover, inhibition of p38 MAPK prevented CLP- or LPS-induced autophagy...
  17. ncbi Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
    P J Lee
    Division of Pulmonary and Critical Care, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:5375-81. 1997
    ..Taken together, these data demonstrate that hypoxia induces HO-1 expression in animal tissues and cell cultures and implicate HIF-1 in this response...
  18. ncbi Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis
    Luz D Orozco
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Circ Res 100:1703-11. 2007
    ..We conclude that HO-1 expression in macrophages constitutes an important component of the antiatherogenic effect by increasing antioxidant protection and decreasing the inflammatory component of atherosclerotic lesions...
  19. doi Endotoxin-induced myeloid-derived suppressor cells inhibit alloimmune responses via heme oxygenase-1
    V de Wilde
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    Am J Transplant 9:2034-47. 2009
    ..Importantly, HO-1 inhibition before CD11b+ cell transfer prevented the delay of allograft rejection revealing a new MDSC-associated suppressor mechanism relevant for transplantation...
  20. ncbi Heme oxygenase-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells
    Joanna Listopad
    TRG Inflammation and Immunology, Bayer Schering Pharma AG, D 13442 Berlin, Germany
    Exp Dermatol 16:661-70. 2007
    ..Suppression of antigen-presenting cells may represent a main anti-inflammatory mechanism of HO-1...
  21. pmc Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet
    Jian Cao
    Department of Geriatric Cardiology, Chinese PLA General Hospital Beijing, China
    Hypertension 60:467-75. 2012
    ..These effects are reversed by the HO activity inhibitor, stannous mesoporphyrin...
  22. ncbi Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2
    Tzong Shyuan Lee
    Division of Cardiovascular Research, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, Republic of China
    J Biol Chem 278:19325-30. 2003
    ..Collectively, these data suggest that even at submicromolar concentrations 15d-PGJ2 can exert an anti-inflammatory effect in macrophages through a mechanism that involves the action of HO/CO...
  23. pmc Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse
    Matthias H Kapturczak
    Division of Nephrology, University of Alabama at Birmingham, Birmingham Alabama, USA
    Am J Pathol 165:1045-53. 2004
    ..The absence of HO-1 correlates with a Th1-weighted shift in cytokine responses suggesting a general pro-inflammatory tendency associated with HO-1 deficiency...
  24. ncbi Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes
    Nastiti Wijayanti
    Institut für Klinische Immunologie und Transfusionsmedizin, Justus Liebig Universitat Giessen, Langhanstrasse 7, D 35392 Giessen, Germany
    J Biol Chem 280:21820-9. 2005
    ..The data suggest that the transcriptional induction of HO-1 gene expression by AEBSF is mediated via activation of a PKB, p38 MAPK signaling pathway...
  25. ncbi Heme oxygenase-1 in vascular smooth muscle cells counteracts cardiovascular damage induced by angiotensin II
    Toshisuke Morita
    Department of Laboratory Medicine, Toho University, School of Medicine, 6 11 1, Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    Curr Neurovasc Res 2:113-20. 2005
    ..The evidence presented in the current study indicates that vascular HO-1 exerts its protective effect against cardiovascular damage, possibly through the inhibition of oxidative stress...
  26. ncbi Heme oxygenase-1 protects brain from acute excitotoxicity
    A S Ahmad
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building 364 365, Baltimore, MD 21205, USA
    Neuroscience 141:1703-8. 2006
    ....
  27. ncbi Haeme oxygenase promotes progenitor cell mobilization, neovascularization, and functional recovery after critical hindlimb ischaemia in mice
    Jörn Tongers
    Department of Cardiology and Angiology, Hannover University Medical School, 30625 Hannover, Germany
    Cardiovasc Res 78:294-300. 2008
    ..We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI)...
  28. pmc Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia
    Emil Zeynalov
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 365, Baltimore, MD 21205, USA
    Neurobiol Dis 35:264-9. 2009
    ..Our goal was to determine if the inducible heme oxygenase 1 (HO1) is required for such protection...
  29. pmc Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantation
    Bo Chen
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Pathol 175:422-9. 2009
    ..These studies demonstrate an important role for systemic HO-1/CO for protection against vascular arterial thrombosis in murine aortic allotransplantation...
  30. pmc An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis
    Shehzad Z Sheikh
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Immunol 186:5506-13. 2011
    ....
  31. doi Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide
    Maria Laura Zenclussen
    Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto von Guericke University, Gerhart Hauptmann Strasse 35, Magdeburg, Germany
    J Pathol 225:293-304. 2011
    ..We unravel a novel physiological role for HO-1/CO in sustaining pregnancy which aids in understanding the biology of pregnancy and reveals a promising therapeutic application in the treatment of pregnancy pathologies...
  32. doi Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages
    Seung Eun Lee
    Department of Microbiology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
    J Ethnopharmacol 139:541-8. 2012
    ..Induction of heme oxygenase-1 (HO-1) expression protects against oxidative stress-induced cell damage, which plays an important role in cytoprotection in a variety of pathological models...
  33. ncbi Heme oxygenase-1 mediated cytoprotection against liver ischemia and reperfusion injury: inhibition of type-1 interferon signaling
    Sei Ichiro Tsuchihashi
    The Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7054, USA
    Transplantation 83:1628-34. 2007
    ..This study focuses on the role of type-1 IFN pathway in the mechanism of HO-1 cytoprotection during liver IRI...
  34. doi Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy
    Chia Chao Wu
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Pineal Res 52:460-9. 2012
    ..Melatonin also upregulated heme oxygenase 1 (HO1) and ameliorated MN...
  35. pmc Heme oxygenase-1 accelerates cutaneous wound healing in mice
    Anna Grochot-Przeczek
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    PLoS ONE 4:e5803. 2009
    ..In summary, induction of HO-1 is necessary for efficient wound closure and neovascularization. Impaired wound healing in diabetic mice may be associated with delayed HO-1 upregulation and can be improved by HO-1 gene transfer...
  36. pmc Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution
    Gennadiy Kovtunovych
    Molecular Medicine Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Blood 116:6054-62. 2010
    ..Thus, in HO-1(-/-) mammals, the reduced function and viability of erythrophagocytosing macrophages are the main causes of tissue damage and iron redistribution...
  37. ncbi Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection
    Ulrike Protzer
    Molecular Infectiology at Center for Molecular Medicine Cologne, Institute for Medical Microbiology, Immunology, and Hygiene, University of Cologne, Cologne, Germany
    Gastroenterology 133:1156-65. 2007
    ..Induction of heme oxygenase-1 (HO-1) has been shown to be beneficial in immune-mediated liver damage. We now investigate the effects of HO-1 induction in models of human hepatitis B virus (HBV) infection...
  38. pmc Adipocyte heme oxygenase-1 induction attenuates metabolic syndrome in both male and female obese mice
    Angela Burgess
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614, USA
    Hypertension 56:1124-30. 2010
    ..These findings offer the possibility of treating not only hypertension, but also other detrimental metabolic consequences of obesity including insulin resistance and dyslipidemia in obese populations by induction of HO-1 in adipocytes...
  39. ncbi Participation of heme oxygenase-1 in a model of acute inflammation
    Ana María Vicente
    Department of Pharmacology, University of Valencia, 46100 Burjasot, Valencia, Spain
    Exp Biol Med (Maywood) 228:514-6. 2003
    ..Our data suggest an anti-inflammatory role for HO-1 in the response induced by this phagocytic stimulus...
  40. ncbi Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability
    Camille Taillé
    INSERM, Unité 408, Institut Federatif de Recherche 02, Faculte de Medecine Xavier Bichat, 75018 Paris, France
    J Biol Chem 279:28681-8. 2004
    ..This study provides a new mechanism to explain HO-1 anti-oxidant properties...
  41. pmc Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice
    YueMin Nan
    Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, PR China
    Lipids Health Dis 9:124. 2010
    ..However, the role of HO-1 on hepatocyte apoptosis remains unclear. We aim to elucidate the effects of HO-1 on oxidative stress related hepatocellular apoptosis in nutritional steatohepatitis in mice...
  42. doi The induction of macrophage hemeoxygenase-1 is protective during acute kidney injury in aging mice
    David A Ferenbach
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Kidney Int 79:966-76. 2011
    ..Thus, failure of HO-1 induction following renal IRI worsens structural and functional injury in older mice and represents a therapeutic target in the elderly. Hence, HO-1-positive renal macrophages mediate HA-induced protection in IRI...
  43. doi Protective effects of adiponectin against renal ischemia-reperfusion injury via prostacyclin-PPARα-heme oxygenase-1 signaling pathway
    Ching Feng Cheng
    Department of Medical Research, Tzu Chi General Hospital, Hualien, Taiwan
    J Cell Physiol 227:239-49. 2012
    ..This provides in vivo evidence that APN mediated HO-1 expression depends on PPARα regulation. In conclusion, our results provide a novel APN mediated prostacyclin-PPARα-HO-1 signaling pathway in protecting renal I/R injury...
  44. pmc Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 286:16374-85. 2011
    ..These findings disclose a highly structured transcriptional network that couples mitochondrial biogenesis to counter-inflammation with major implications for immune suppression in sepsis...
  45. ncbi Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene
    Hiroshi Suzuki
    Department of Biomedical Chemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    J Biol Chem 278:49246-53. 2003
    ..These results indicate that the nuclear export of Bach1 constitutes an important regulatory mechanism to relieve the Bach1-mediated repression of genes such as ho-1...
  46. doi Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice
    Gabor Czibik
    Department of Physiology, IMB, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103, Blindern, NO 0317 Oslo, Norway
    Cardiovasc Res 82:107-14. 2009
    The present study investigates whether the cardioprotection achieved by gene delivery of hypoxia-inducible factor-1 alpha (HIF-1 alpha) depends on the downstream factor haem oxygenase (HMOX)-1.
  47. doi Anti-inflammatory effects of sulfuretin from Rhus verniciflua Stokes via the induction of heme oxygenase-1 expression in murine macrophages
    Dong Sung Lee
    College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570 749, Republic of Korea
    Int Immunopharmacol 10:850-8. 2010
    ..This indicated that the anti-inflammatory effects of sulfuretin in macrophages might be exerted through a novel mechanism that involves HO-1 expression...
  48. pmc Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1
    Nadia G Innamorato
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Instituto de Investigación Sanitaria La Paz IdiPaz, Madrid, Spain
    PLoS ONE 5:e11838. 2010
    ..Before targeting Nrf2 for PD therapy it is imperative to determine if HO-1 is neurotoxic or neuroprotective in the basal ganglia...
  49. doi Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway
    Paul Waltz
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA USA
    Autophagy 7:315-20. 2011
    ..We found that LPS induced autophagic signaling in macrophages via a TLR4, HO-1 dependent pathway in macrophages. These data add to the developing contribution of autophagic signaling as part of the inflammatory response...
  50. ncbi Phosphatidylinositol 3-kinase/Akt pathway mediates heme oxygenase-1 regulation by lipopolysaccharide
    S E Pischke
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, MUH 628NW, Pittsburgh, Pennsylvania 15213, USA
    Cell Mol Biol (Noisy-le-grand) 51:461-70. 2005
    ..We demonstrate, to our knowledge for the first time, that upon proinflammatory stimulation heme oxygenase-1 gene expression in macrophages depends on PI3K/Akt and p38 MAPK acting upstream of Nrf2-dependent promoter activation...
  51. ncbi Endotoxin-induced down-regulation of Elk-3 facilitates heme oxygenase-1 induction in macrophages
    Su Wol Chung
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 176:2414-20. 2006
    ..Taken together, our data reveal that Elk-3 serves as an important repressor of HO-1 gene transcription and contributes to the tight control of HO-1 gene regulation in the setting of inflammatory stimuli...
  52. doi Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo
    Henna Kaisa Jyrkkänen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, Finland
    Circ Res 103:e1-9. 2008
    ..We suggest that the activation of Nrf2 by oxidized phospholipids provides a mechanism by which their deleterious effects are limited in the vasculature...
  53. ncbi Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells
    Jozef Dulak
    Division of Cardiology, Innsbruck University, Innsbruck, Austria
    Antioxid Redox Signal 4:229-40. 2002
    ..As CO and iron, respectively the inducer and the inhibitor of VEGF synthesis, are concomitantly produced during the degradation of heme, these data indicate that HO by-products may differentially modulate VEGF production...
  54. ncbi Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide
    Giuseppe A Ricchetti
    Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, UK
    J Leukoc Biol 76:719-26. 2004
    ..In summary, although IL-10 does regulate HO-1 expression, it does not appear to play a significant role in the anti-inflammatory activity of the cytokine...
  55. ncbi Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection
    Tzong Shyuan Lee
    Division of Biomedical Sciences, University of California, Riverside, CA 92521 0121, USA
    Circulation 110:1296-302. 2004
    ..Here, we studied whether heme oxygenase-1 (HO-1), an important cytoprotective molecule, is induced by simvastatin and the role of HO-1 in the pleiotropic effects of simvastatin...
  56. ncbi Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice
    Xiaoli Liu
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis St, Thorn 932A, Boston, MA 02115, USA
    Diabetes 54:778-84. 2005
    ..Our data demonstrate that the absence of HO-1 renders animals more susceptible to myocardial ischemia/reperfusion damage and diabetes worsens the injury...
  57. pmc Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway
    Refaat A F Hegazi
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Exp Med 202:1703-13. 2005
    ..In conclusion, this study begins to elucidate potential etiologic and therapeutic implications of CO and the HO-1 pathway in chronic inflammatory bowel diseases...
  58. ncbi Heme oxygenase-1 gene transfer inhibits angiotensin II-mediated rat cardiac myocyte apoptosis but not hypertrophy
    Roger S Y Foo
    Division of Cardiovascular Medicine, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, UK
    J Cell Physiol 209:1-7. 2006
    ..Our findings identify the signalling pathways by which HO-1 gene transfer protects against apoptosis and suggest that overexpression of HO-1 in cardiomyopathies may delay the transition from myocyte hypertrophy to heart failure...
  59. ncbi The neuroprotective effect of heme oxygenase (HO) on oxidative stress in HO-1 siRNA-transfected HT22 cells
    Asuka Kaizaki
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    Brain Res 1108:39-44. 2006
    ..These results suggest that inducible HO-1 plays a protective role against oxidative stress in HT22 cells...
  60. pmc Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice
    Su Wol Chung
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:239-47. 2008
    ..These data advocate HO-1-derived CO as an important mediator of the host defense response to sepsis and suggest CO administration as a possible treatment for the disease...
  61. ncbi The transcription factor Nrf2 is a therapeutic target against brain inflammation
    Nadia G Innamorato
    Departamento de Bioquímica e Instituto de Investigaciones Biomédicas Alberto Sols Consejo Superior de Investigaciones Científicas Universidad Autónoma, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 181:680-9. 2008
    ..This study opens the possibility of targeting Nrf2 in brain as a means to modulate neuroinflammation...
  62. pmc Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans
    Abdelhamid Almolki
    INSERM U700, Universite Paris 7, Paris, France
    Am J Pathol 173:981-92. 2008
    ..7% versus 8.6%, P = 0.047). No such results were observed in those who had never smoked (n = 297). We conclude that HO-1 has a significant protective effect against airway mucus hypersecretion in animals and humans exposed to CS...
  63. doi The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1
    Xiao Mei Wang
    Division of Pulmonary, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 182:3809-18. 2009
    ..Upon LPS stimulation, HO-1 trafficked to the caveolae by a p38 MAPK-dependent mechanism, where it down-regulated proinflammatory signaling. These results reveal an anti-inflammatory network involving cav-1 and HO-1...
  64. ncbi Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene
    J Alam
    Department of Molecular Genetics, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121
    J Biol Chem 267:21894-900. 1992
    ..These functions are mediated by the AP-1 binding sites as multiple copies of the region A motif also confer TPA induction and c-Jun/c-Fos transactivation upon a heterologous promoter...
  65. ncbi Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5' sequences are required for induction by heme or heavy metals
    J Alam
    Department of Molecular Genetics, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121
    J Biol Chem 269:1001-9. 1994
    ..A 5-7-fold difference in the levels of induction between stably integrated and transiently expressed mouse HO-1 gene constructs is observed in this cell line.(ABSTRACT TRUNCATED AT 400 WORDS)..
  66. pmc Heme oxygenase 1 is required for mammalian iron reutilization
    K D Poss
    Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:10919-24. 1997
    ..Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99...
  67. pmc Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice
    S F Yet
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 103:R23-9. 1999
    ..Our data suggest that in the absence of HO-1, cardiomyocytes have a maladaptive response to hypoxia and subsequent pulmonary hypertension. J.Clin. Invest. 103:R23-R29 (1999)...
  68. pmc The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo
    K A Nath
    Nephrology Research Unit, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Am J Pathol 156:1527-35. 2000
    ..We conclude that the induction of HO-1 is an indispensable response in protecting against acute heme protein toxicity in vivo...
  69. ncbi Heme oxygenase-1 protects against vascular constriction and proliferation
    H J Duckers
    Vascular Biology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Nat Med 7:693-8. 2001
    ..Induction of the HO-1 pathway moderates the severity of vascular injury by at least two adaptive mechanisms independent of nitric oxide, and is a potential therapeutic target for diseases of the vasculature...
  70. ncbi Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
    Tzong Shyuan Lee
    Graduate Institute of Life Sciences, National Defense Medical Center, and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    Nat Med 8:240-6. 2002
    ..The identification of HO-1 as a downstream effector of IL-10 provides new possibilities for improved therapeutic approaches for treating inflammatory diseases...
  71. ncbi Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis
    Sophie Brouard
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:17950-61. 2002
    ..e. c-IAP2 and A1, to protect EC from TNF-alpha-mediated apoptosis. This effect is dependent on the ability of HO-1/CO to activate the p38 MAPK signal transduction pathway...
  72. ncbi Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon-gamma-induced heme oxygenase 1 and prevent RAW264.7 macrophages from UV-irradiation-induced cell death
    Yen Chou Chen
    Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taiwan
    J Cell Biochem 86:331-9. 2002
    ..These results demonstrated that inflammatory molecules NO and PGE(2) were potent inducers of HO-1 gene, and protected cells from UV-irradiation-induced cell death through HO-1 induction...
  73. pmc Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene
    Jiying Sun
    Department of Biomedical Chemistry, Hiroshima University Graduate School of Biomedical Sciences, Kasumi 1 2 3, Hiroshima 734 8551, Japan
    EMBO J 21:5216-24. 2002
    ..Thus, regulation of ho-1 involves a direct sensing of heme levels by Bach1 (by analogy to lac repressor sensitivity to lactose), generating a simple feedback loop whereby the substrate effects repressor-activator antagonism...
  74. ncbi Nitric oxide-mediated cytoprotection of hepatocytes from glucose deprivation-induced cytotoxicity: involvement of heme oxygenase-1
    Byung Min Choi
    Medicinal Resources Research Center MRRC and the Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea
    Hepatology 37:810-23. 2003
    ..Thus, HO-1 might be an important cellular target of NO donor with clinical implications for the prevention of acute liver injury in several pathological conditions...
  75. ncbi Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX
    Alicja Jozkowicz
    Department of Vascular Surgery, University of Vienna, Austria
    Antioxid Redox Signal 5:155-62. 2003
    ..Thus, HO activity up-regulates VEGF production and augments the capability of endothelial cells to respond to exogenous stimulation...
  76. ncbi Heme oxygenase-1-related carbon monoxide production and ventricular fibrillation in isolated ischemic/reperfused mouse myocardium
    Istvan Bak
    Department of Pharmacology, Health and Science Center, University of Debrecen, Nagyerdei krt 98, 4032 Debrecen, Hungary
    FASEB J 17:2133-5. 2003
    ..Thus, interventions that are able to increase endogenous CO may prevent the development of VF...
  77. pmc Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 198:1707-16. 2003
    ..is known that CO can induce production of NO and that NO can induce expression of the cytoprotective enzyme heme oxygenase 1 (HO-1), there is no information whether the protective effect of CO ever requires NO production or whether ..
  78. ncbi Role of heme oxygenase-1 in hydrogen peroxide-induced VEGF synthesis: effect of HO-1 knockout
    Jarosław Cisowski
    Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    Biochem Biophys Res Commun 326:670-6. 2005
    ..Additionally, knock out of HO-1 gene impaired induction of VEGF by hemin, lysophosphatidylcholine, and prostaglandin-J(2). Our results provide confirmation for the involvement of HO-1 in regulation of angiogenesis...
  79. ncbi HO-1 upregulation suppresses type 1 IFN pathway in hepatic ischemia/reperfusion injury
    S Tsuchihashi
    The Dumont UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7054, USA
    Transplant Proc 37:1677-8. 2005
    ..In contrast, adjunctive CoPP treatment decreased IP-10 levels in mouse livers infused with rIFN-beta. Thus, CoPP-induced HO-1 upregulation suppresses type-1 IFN pathway downstream of TLR4 system in hepatic warm I/R injury model...
  80. ncbi MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates
    Siobhan T Pittock
    Department of Pediatric and Adolescent Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 68:611-22. 2005
    ..The present study was stimulated by the hypothesis that expression of MCP-1 is suppressed by HO-1, and analyzed the effect of HO-1 on the expression of MCP-1 in stressed and unstressed conditions...
  81. ncbi Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection
    Helena Parfenova
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    Am J Physiol Cell Physiol 290:C1399-410. 2006
    ..Although HO-1, when induced, provides powerful protection, HO-2 is an essential endogenous anti-apoptotic factor against glutamate toxicity in the cerebral vascular endothelium...
  82. ncbi Inhibition of heme oxygenase-1 interferes with the transforming activity of the Kaposi sarcoma herpesvirus-encoded G protein-coupled receptor
    Maria Julia Marinissen
    Instituto de Investigaciones Biomédicas A Sols Universidad Autónoma de Madrid Consejo Superior de Investigaciones Científicas, Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid 28029, Spain
    J Biol Chem 281:11332-46. 2006
    ..These data postulate HO-1 as an important mediator of vGPCR-induced tumor growth and suggest that inhibition of intratumoral HO-1 activity by SnPP may be a potential therapeutic strategy...
  83. ncbi Basal rather than induced heme oxygenase-1 levels are crucial in the antioxidant cytoprotection
    Sei Ichiro Tsuchihashi
    Division of Liver and Pancreas Transplantation, Department of Surgery, Dumont University of California Los Angeles Transplant Center, Los Angeles, CA 90095, USA
    J Immunol 177:4749-57. 2006
    ..This model provides an opportunity to further our understanding of HO-1 in stress defense mechanisms and design new regimens to prevent IRI...
  84. pmc Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death
    Dirk Jan Slebos
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, MUH 628NW, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Am J Respir Cell Mol Biol 36:409-17. 2007
    ..We demonstrate the functional compartmentalization of heme oxygenase-1 in the mitochondria of lung epithelial cells, and its potential role in defense against mitochondria-mediated cell death during CSE exposure...
  85. ncbi Heme oxygenase-1 is not required for mouse regulatory T cell development and function
    Santiago Zelenay
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 6, Apartado 14, 2780 901 Oeiras, Portugal
    Int Immunol 19:11-8. 2007
    ..We compared wild-type and heme oxygenase-1-deficient (hmox-1(-/-)) mice in order to assess the role of HO-1 in mouse Treg development and function under physiologic ..
  86. pmc Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation
    Angelo A Chora
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal Departamento de Imunologia, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Lisbon, Portugal
    J Clin Invest 117:438-47. 2007
    ..In conclusion, HO-1 or exposure to its end product CO counters autoimmune neuroinflammation and thus might be used therapeutically to treat MS...
  87. pmc Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism
    Jessy Deshane
    Department of Medicine, Nephrology Research and Training Center and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 204:605-18. 2007
    ..We provide direct evidence demonstrating an important role for heme oxygenase 1 (HO-1) in mediating the proangiogenic effects of SDF-1...
  88. ncbi Pharmacologic induction of heme oxygenase 1 reduces acute inflammatory arthritis in mice
    Mourad Benallaoua
    INSERM U 747, and Universite Paris Descartes, 45 Rue des Saintes Pères, 75006 Paris, France
    Arthritis Rheum 56:2585-94. 2007
    To determine the consequences of pharmacologic up-regulation of heme oxygenase 1 (HO-1), and inhibition of HO-1 by injection of an anti-HO-1 small interfering RNA (siRNA), in vivo in the acute phase of a mouse model of nonautoimmune ..
  89. pmc Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon
    Ashwani Kumar
    Department of Microbiology, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Biol Chem 283:18032-9. 2008
    ..We conclude that CO, a previously unrecognized host factor, is a physiologically relevant Mtb signal capable of inducing the Dos regulon, which introduces a new paradigm for understanding the molecular basis of Mtb persistence...
  90. pmc Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors
    Yu An Cao
    Departments of Pediatrics, Stanford University School of Medicine, CA, USA
    Blood 112:4494-502. 2008
    ..Control of stem cell stress response by HO-1 presents opportunities for metabolic manipulation of stem cell-based therapies...
  91. pmc Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells
    James F George
    Departments of Surgery, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Pathol 173:154-60. 2008
    ..These findings demonstrate that HO-1 activity in antigen-presenting cells is important for Treg-mediated suppression, providing an explanation for the apparent defect in immune regulation in HO-1(-/-) mice...
  92. doi Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1
    Heng Huei Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, ROC
    J Mol Cell Cardiol 45:44-55. 2008
    ..These data suggest that cardiac HO-1 gene transfer post MI provides protection at least in part by promoting neovascularization through inducing angiogenic factors and the recruitment of circulating progenitor/stem cells...
  93. doi Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 10:1767-812. 2008
    ....
  94. pmc Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Circ Res 103:1232-40. 2008
    ....
  95. pmc Bach1 modulates heme oxygenase-1 expression in the neonatal mouse lung
    Sacha Kassovska-Bratinova
    Division of Neonatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pediatr Res 65:145-9. 2009
    ..These data suggest that elevated levels of Bach1 may help to limit HO-1 induction in the newborn at baseline and in response to oxidative stress...
  96. doi Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin
    Anne R Kinderlerer
    Bywaters Center for Vascular Inflammation, Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK
    Blood 113:1598-607. 2009
    ....
  97. ncbi Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments
    Takashi Mamiya
    Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, Exploratory Research for Advanced Technology Japan Science and Technology Corporation, Tsukuba, Japan
    Tohoku J Exp Med 216:331-9. 2008
    ..HO-1 CKO mice were susceptible to carbon tetrachloride hepatotoxicity. These results provide the first in vivo evidence that HO-1 acts to protect cells against the oxidative stress in both basal conditions and upon chemical insult...
  98. doi Cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis
    Mohammad Hasan Zaki
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Immunol 182:3746-56. 2009
    ..In this study, we report a unique signal pathway for cytoprotection during Salmonella infection that involves heme oxygenase 1 (HO-1) induced by a nitrated cyclic nucleotide, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP)...
  99. pmc Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production
    Sotiria Tzima
    Biomedical Sciences Research Center Alexander Fleming, Vari 166 72, Greece
    J Exp Med 206:1167-79. 2009
    ..These results uncover a novel direct function for myeloid HO-1 in the regulation of IFN-beta production, establishing HO-1 as a critical early mediator of the innate immune response...
  100. doi Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque
    Caroline Cheng
    Molecular Cardiology Laboratory, Experimental Cardiology, Thoraxcenter, Erasmus University Medical Center Rotterdam, Rotterdam 3015 CE, The Netherlands
    Circulation 119:3017-27. 2009
    The molecular regulation for the transition from stable to vulnerable plaque remains to be elucidated. Heme oxygenase 1 (HO-1) and its metabolites have been implicated in the cytoprotective defense against oxidative injury in ..
  101. doi Heme oxygenase-1 increases endothelial progenitor cells
    Ben J Wu
    Centre for Vascular Research, School of Medical Sciences and Bosch Institute, Faculty of Medicine, University of Sydney, NSW 2006, Australia
    Arterioscler Thromb Vasc Biol 29:1537-42. 2009
    ..As endothelial progenitor cells (EPCs) contribute to reendothelialization, we examined the role of HO-1 on bone marrow and circulating EPCs...

Research Grants20

  1. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010
    ..abstract_text> ..
  2. Karl A Nath; Fiscal Year: 2016
    ..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
  3. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2008
    ..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
  4. HEMEOXYGENASE1--REGULATION AND FUNCTION AFTER HYPEROXIA
    PATTY LEE; Fiscal Year: 2002
    ..3) Determine the functional role of HO-1 after hyperoxia in vitro following hyperoxia. 4) Determine the functional role of HO-1 after hyperoxia in vivo using HO- 1 transgenic and knock-out mice. ..
  5. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
    ..This grant seeks to understand the balance between these injurious and protective substances, to develop strategies which may tip the balance in favor of protecting transplanted lungs from lethal injury. ..
  6. PRESERVATION AND CARDIAC TRANSPLANT VASCULOPATHY
    David Pinsky; Fiscal Year: 2003
    ..These experiments will provide new insights into mechanisms by which early ischemic injury leads to early graft failure and TCAD, and proffer new strategies for prevention. ..
  7. BIOLOGY AND CONTROL OF LYME DISEASE BORRELIA
    Alan Barbour; Fiscal Year: 2004
    ..burgdorferi, its transmission, and reservoir host immunize responses. The results may also have relevance for the control of other vector-bone zoonotic diseases and perhaps for development of novel methods for vaccine delivery. ..
  8. LEUKOREGULATION BY CD39 IN LUNG ISCHEMIA AND INFLAMMATI*
    David Pinsky; Fiscal Year: 2004
    ..abstract_text> ..
  9. THROMBOREGULATORY ROLE OF CD39 (ECTOADPASE) IN STROKE
    David Pinsky; Fiscal Year: 2004
    ..This collaboration, based on compelling feasibility data and historical collaborative success, will advance the understanding of CD39 thromboregulation, and lead to a novel therapeutic agent for thrombotic diatheses. ..
  10. LEUKOCYTE ADHESION RECEPTORS AND THROMBOSIS IN STROKE
    David Pinsky; Fiscal Year: 2006
    ..Overall these studies will identify unifying molecular events which link micro vascular coagulation and inflammation in stroke. ..
  11. THE VASCULAR BIOLOGY OF LUNG PRESERVATION
    David Pinsky; Fiscal Year: 2008
    ..These studies may lead to harnessing inspired "toxic" gases to improve outcomes after lung transplantation. [unreadable] [unreadable]..
  12. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    ..heme uptake pathways will have a great impact in understanding disorders associated with iron overload (hereditary hemochromatosis, iron overload secondary to blood transfusions) and nutritional iron deficiency [unreadable] [unreadable]..
  13. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  14. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  15. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  16. Elucidation of nitric oxide resistance mechanisms in motor neurons
    Amy Bishop; Fiscal Year: 2008
    ..IAR is dependent on the heme metabolizing enzyme, heme oxygenase 1 (HO-1)...
  17. ARGINASE AND ARTERIAL INJURY
    William Durante; Fiscal Year: 2009
    ....
  18. Role of Cysteine-rich Protein 2 in Vascular Disease
    Shaw Fang Yet; Fiscal Year: 2005
    ..abstract_text> ..
  19. MOLECULAR MECHANISMS OF BONE MARROW INDUCED TOLERANCE
    James George; Fiscal Year: 2003
    ..The information generated will provide information regarding the specific cellular and subcellular events that are critical to the induction and maintenance of tolerance in this system. ..
  20. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....