H2-K1

Summary

Gene Symbol: H2-K1
Description: histocompatibility 2, K1, K region
Alias: H-2K, H-2K(d), H2-K, H-2 class I histocompatibility antigen, K-W28 alpha chain, H-2 class I histocompatibility antigen, K-B alpha chain, H-2 class I histocompatibility antigen, K-D alpha chain, H-2 class I histocompatibility antigen, K-K alpha chain, H-2 class I histocompatibility antigen, K-Q alpha chain, H-2K(B), H-2K(K), H-2K(Q), MHC H2-K transplantation antigen, MHC class I H2-K-b-alpha-2 cell surface glycoprotein, MHC class I antigen, MHC class I heavy chain H2-K, class I major histocompatibility antigen H-2Kd
Species: mouse

Top Publications

  1. ncbi Cutting edge: naive T cells masquerading as memory cells
    K Murali-Krishna
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 165:1733-7. 2000
  2. ncbi Cytotoxic T cell responses in HLA-A2.1 transgenic mice. Recognition of HLA alloantigens and utilization of HLA-A2.1 as a restriction element
    A X Le
    Department of Surgery, University of Virginia Medical Center, Charlottesville 22908
    J Immunol 142:1366-71. 1989
  3. pmc HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice
    S Pascolo
    Institut Pasteur, Département SIDA Rétrovirus, Unité d Immunité Cellulaire Antivirale, 75724 Paris Cedex 15, France
    J Exp Med 185:2043-51. 1997
  4. pmc Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells
    Y Vugmeyster
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:12492-7. 1998
  5. ncbi Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb
    P S Kern
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Immunity 9:519-30. 1998
  6. ncbi Response to Listeria monocytogenes in mice lacking MHC class Ia molecules
    M S Seaman
    Immunology Graduate Program, Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 162:5429-36. 1999
  7. ncbi Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses
    B Perarnau
    Département SIDA Rétrovirus, Institut Pasteur, Paris, France
    Eur J Immunol 29:1243-52. 1999
  8. ncbi Persistence of memory CD8 T cells in MHC class I-deficient mice
    K Murali-Krishna
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA
    Science 286:1377-81. 1999
  9. pmc IL-7 is critical for homeostatic proliferation and survival of naive T cells
    J T Tan
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:8732-7. 2001
  10. pmc Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors
    James R Carlyle
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, 485 Life Sciences Addition, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 101:3527-32. 2004

Research Grants

  1. Activation of innate antiviral defenses by LTbetaR
    CHRISTOPHER BENEDICT; Fiscal Year: 2005
  2. CD8 T Lymphocyte Regulation of EAE Disease Phenotype
    Michael Carrithers; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications122 found, 100 shown here

  1. ncbi Cutting edge: naive T cells masquerading as memory cells
    K Murali-Krishna
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 165:1733-7. 2000
    ..In addition, this study may have implications for autoimmunity because homeostatic proliferation of naive T cells requires interaction with self peptide plus MHC molecules...
  2. ncbi Cytotoxic T cell responses in HLA-A2.1 transgenic mice. Recognition of HLA alloantigens and utilization of HLA-A2.1 as a restriction element
    A X Le
    Department of Surgery, University of Virginia Medical Center, Charlottesville 22908
    J Immunol 142:1366-71. 1989
    ..1 acts as a restricting element for human nominal Ag. These results are discussed in the context of current models of T cell repertoire development...
  3. pmc HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice
    S Pascolo
    Institut Pasteur, Département SIDA Rétrovirus, Unité d Immunité Cellulaire Antivirale, 75724 Paris Cedex 15, France
    J Exp Med 185:2043-51. 1997
    ..1-restricted immunodominant epitope in humans. Such mice might constitute a versatile animal model for the study of HLA-A2.1-restricted CTL responses of vaccine interest...
  4. pmc Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells
    Y Vugmeyster
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:12492-7. 1998
    ..KbDb -/- animals also have natural killer cells that retain their cytotoxic potential...
  5. ncbi Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb
    P S Kern
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Immunity 9:519-30. 1998
    ....
  6. ncbi Response to Listeria monocytogenes in mice lacking MHC class Ia molecules
    M S Seaman
    Immunology Graduate Program, Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 162:5429-36. 1999
    ..Thus, class Ia-deficient animals have a CD8+ T cell repertoire capable of recognizing both class Ia and class Ib molecules and can generate protective immunity to LM...
  7. ncbi Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses
    B Perarnau
    Département SIDA Rétrovirus, Institut Pasteur, Paris, France
    Eur J Immunol 29:1243-52. 1999
    ..Mice expressing a restricted set of histocompatibility class I molecules should represent useful tools to evaluate the immunological potentials of individual MHC class I molecules...
  8. ncbi Persistence of memory CD8 T cells in MHC class I-deficient mice
    K Murali-Krishna
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA
    Science 286:1377-81. 1999
    ..Thus, after naïve CD8 T cells differentiate into memory cells, they evolve an MHC class I-independent "life-style" and do not require further stimulation with specific or cross-reactive antigen for their maintenance...
  9. pmc IL-7 is critical for homeostatic proliferation and survival of naive T cells
    J T Tan
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:8732-7. 2001
    ..Thus, naïve T cells disappeared gradually over a 1-month period upon adoptive transfer into IL-7(-) hosts. These findings indicate that naive T cells depend on IL-7 for survival and homeostatic proliferation...
  10. pmc Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors
    James R Carlyle
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, 485 Life Sciences Addition, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 101:3527-32. 2004
    ..Remarkably, Ocil/Clr-b is frequently down-regulated on mouse tumor cell lines, indicating a role for this receptor-ligand system in a new form of "missing self-recognition" of tumor cells...
  11. pmc Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules
    Sofia Johansson
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Exp Med 201:1145-55. 2005
    ....
  12. pmc Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense
    Honglin Xu
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 203:449-59. 2006
    ..Thus, the early H2-M3-restricted response temporally bridges the gap between innate and adaptive immune responses, subsequently affecting the function of both branches of the immune system...
  13. ncbi In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides
    Gianna Elena Hammer
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Immunol 8:101-8. 2007
    ..Thus, ERAAP is a 'quintessential editor' of the peptide-MHC repertoire and, paradoxically, its absence enhances immunogenicity...
  14. doi The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells
    Petter Brodin
    Department of Microbiology, Tumor and Cell Biology, Strategic Research Center for Studies of Integrative Recognition in the Immune System IRIS, Karolinska Institutet, corrected Stockholm, Sweden
    Blood 113:2434-41. 2009
    ..Our data suggest that the capacity of an individual NK cell to respond to stimulation is quantitatively controlled by the extent of inhibitory signals that are received from MHC class I molecules during NK-cell education...
  15. doi Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction
    Sebastian Thams
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurosci 29:13503-15. 2009
    ....
  16. pmc Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity
    Akash Datwani
    Departments of Biology, James H Clark Center, Stanford University, Stanford, CA 94305, USA
    Neuron 64:463-70. 2009
    ..H2-K(b) and H2-D(b) ligands, signaling via neuronal MHCI receptors, may enable activity-dependent remodeling of brain circuits during developmental critical periods...
  17. pmc Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells
    Nicolas Blanchard
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 184:3033-42. 2010
    ..Thus, the characteristic length, as well as the composition of MHC-I peptide cargo, is determined not only by the MHC-I peptide-binding groove but also by ERAAP proteolysis in the endoplasmic reticulum...
  18. pmc Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3
    Hoonsik Cho
    Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611, USA
    J Immunol 186:489-98. 2011
    ..These data demonstrate that other MHC class Ib-restricted CD8(+) T cells, in addition to H2-M3-restricted T cells, contribute to antilisterial immunity and may contribute to immune responses against other intracellular bacteria...
  19. pmc Neuroprotection from stroke in the absence of MHCI or PirB
    Jaimie D Adelson
    Department of Biology and Neurobiology, Stanford University, Stanford, CA 94305 5437, USA
    Neuron 73:1100-7. 2012
    ..Thus, molecules that function in the immune system act not only to limit synaptic plasticity in healthy neurons, but also to exacerbate brain injury after ischemia. These results suggest therapies for stroke by targeting MHCI and PirB...
  20. ncbi MHC class Ia-restricted T cells partially account for beta2-microglobulin-dependent resistance to Mycobacterium tuberculosis
    M S Rolph
    Dept of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Eur J Immunol 31:1944-9. 2001
    ..Thus, antigen presentation via MHC class Ia is an important component in resistance to M. tuberculosis, but its absence only partially accounts for the increased susceptibility of beta 2-microglobulin-deficient mice...
  21. ncbi Beta2-microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2Kb and Db heavy chains
    P Hoglund
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Eur J Immunol 28:370-8. 1998
    ..However, the mechanisms for enhanced inhibition by MHC class I molecules appear to be unrelated to self tolerance in beta2m- mice, which may instead operate through mechanisms involving triggering pathways...
  22. ncbi MHC class Ib-restricted CTL provide protection against primary and secondary Listeria monocytogenes infection
    M S Seaman
    Immunology Graduate Program and Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    J Immunol 165:5192-201. 2000
    ..Together, these data demonstrate that class Ib-restricted CTL play an important role in clearing a primary LM infection and generate a memory population capable of providing significant protection against subsequent infection...
  23. ncbi The source of early IFN-gamma that plays a role in Th1 priming
    G Das
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 167:2004-10. 2001
    ..Therefore, they arise on MHC class Ib molecules that do not depend on TAP-1 transporters...
  24. ncbi Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection
    S E D'Orazio
    Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 171:291-8. 2003
    ..monocytogenes challenge. These results suggest that even a limited number of class Ib MHC-restricted T cells are sufficient to generate the rapid recall response required for protection against secondary infection with L. monocytogenes...
  25. pmc Insertion of the B2 sequence into intron 13 is the only defect of the H-2k C4 gene which causes low C4 production
    J H Zheng
    Department of Immunobiology, Kanazawa University, Japan
    Nucleic Acids Res 20:4975-9. 1992
    ..These results demonstrated that the insertion of B2 sequence into intron 13 of the C4 gene is the only determinant of low C4 production by H-2k mice through aberrant RNA processing...
  26. ncbi Wonky mice and MBP promoter
    A M Turnley
    Nature 355:594. 1992
  27. pmc Loss of heterozygosity and mitotic linkage maps in the mouse
    V Henson
    Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 88:6486-90. 1991
    ....
  28. ncbi Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice
    H Ha
    Department of Zoology, University of Texas, Austin 78712 1064
    Dev Genet 12:318-32. 1991
    ..Interestingly, four Tctex genes show differences in the amount of transcript between wild-type and t-mutant testes. The chromosomal location and expression pattern imply that Tctex genes might be candidate genes for sterility or TRD...
  29. ncbi Meiotic mapping of murine chromosome 17: the string of loci around l(17)-2Pas
    T R King
    Laboratory of Genetics, University of Wisconsin Madison 53706
    Mamm Genome 1:37-46. 1991
    ..Robust genetic maps can be constructed with multilocus crosses that share anchor loci. DNA markers can be interpolated onto these maps retrospectively...
  30. ncbi Three new t-haplotypes of Mus musculus reveal structural similarities to t-haplotypes of Mus domesticus
    J Forejt
    Genet Res 51:111-9. 1988
  31. ncbi DNA sequence analysis of the C3H H-2Kk and H-2Dk loci. Evolutionary relationships to H-2 genes from four other mouse strains
    S Watts
    Department of Genetics, University of California, Berkeley 94720
    J Immunol 139:3878-85. 1987
    ..Future considerations for evolutionary analysis of class I genes are discussed...
  32. pmc The I region of the C57BL/10 mouse: characterization and physical linkage to H-2K of an SB beta-like class II pseudogene, psi A beta 3
    G Widera
    Proc Natl Acad Sci U S A 82:5500-4. 1985
    ..This suggests that psi A beta 3 is a pseudogene...
  33. ncbi Variations among sublines of inbred AKR mice
    R T Acton
    Nat New Biol 245:8-10. 1973
  34. pmc Isolation of a cDNA clone for the murine transplantation antigen H-2Kb
    A A Reyes
    Proc Natl Acad Sci U S A 79:3270-4. 1982
    ....
  35. ncbi Polymorphism of the Apl (Neu-1) locus in the mouse
    D Klein
    Immunogenetics 16:181-4. 1982
  36. ncbi Alternatively spliced MHC class I mRNAs show specific deletion of sequences encoding the extracellular polymorphic domains
    M M Abu-Hadid
    Department of Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
    Int Immunol 6:323-37. 1994
    ..Potential significance of these domain-lacking H-2 mRNAs is discussed, particularly with regard to the function of the putative encoded peptides as targets of natural killer cells...
  37. ncbi Divergent effects of H-2K and H-2D genes on sensitivity of BL6 melanoma cells to NK cells or TNF-mediated cytotoxicity
    M Kim
    Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine, Pennsylvania 15213
    Cell Immunol 155:358-71. 1994
    ..It is possible that the H-2K gene-induced elimination of the endogenous retroviruses might be responsible for the observed increased sensitivity of BL6 melanoma cells to NK cell- and TNF-mediated cytotoxicity...
  38. pmc Unusual mutation clusters provide insight into class I gene conversion mechanisms
    L R Pease
    Department of Immunology, Mayo Graduate School, Rochester, Minnesota 55905
    Mol Cell Biol 13:4374-81. 1993
    ..The unusual mutation clusters are consistent with a hypothetical gene conversion model involving extrachromosomal intermediates...
  39. ncbi Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL
    J A Speir
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Immunity 10:51-61. 1999
    ..These features of the Kb/RGY8-6H-Gal2 structure are consistent with the individual ligand binding preferences identified for the alpha/beta and gamma/delta TCRs and thus explain the generation of a carbohydrate-specific T cell response...
  40. pmc Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells
    J Zerrahn
    Department of Molecular Biology, Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 96:11470-5. 1999
    ..The possibility that hematopoietic cell-induced, positive selection occurs only with TCRs that exhibit relatively high avidity interactions with selecting ligands in the thymus is discussed...
  41. pmc Mouse histocompatibility genes: structure and organisation of a Kd gene
    S Kvist
    European Molecular Biology Laboratory, Heidelberg, FRG
    EMBO J 2:245-54. 1983
    ..Analyses of exon donor and acceptor sites of different H-2 genes and cDNAs show that alternative splicing sites are used by different genes...
  42. pmc The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo
    Megan S Ford
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 196:261-7. 2002
    ..These findings clearly demonstrate that B6/lpr DNTC have a potent immune regulatory function in vitro and in vivo. They also provide new insights into the mechanisms involved in the development of autoimmune disease in lpr mice...
  43. pmc Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway
    Linrong Lu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Immunity 26:593-604. 2007
    ....
  44. pmc Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1/PD-1 pathway
    Chris A Benedict
    Department of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 180:4836-47. 2008
    ..These data suggest that murine CMV programs infected DC during acute infection to inhibit early host adaptive antiviral responses by tipping the balance between negative and positive cosignals...
  45. pmc Cutting edge: MHC class I-Ly49 interaction regulates neuronal function
    Ofer Zohar
    Blanchette Rockefeller Neurosciences Institute, Johns Hopkins University Montgomery County Campus, Rockville, MD 20850, USA
    J Immunol 180:6447-51. 2008
    ..Because we show that Ly49 genes are selectively expressed in the adult brain, these findings suggest an unsuspected role for the MHC-I-Ly49 interaction in the development and function of the brain...
  46. doi Requirements for control of B-cell lymphoma by NK cells
    Christoph D Brenner
    Helmholtz Zentrum Munchen, Deutsches Forschungszentrum für Gesundheit und Umwelt, Institut für Molekulare Immunologie, Munchen, Germany
    Eur J Immunol 40:494-504. 2010
    ..Thus, NK-receptor coengagement is crucial for NK-cell functions in vivo and especially for NK cell-mediated tumor surveillance...
  47. pmc Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented
    Nathalie Escande-Beillard
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90024, USA
    J Immunol 184:816-23. 2010
    ..Consistent with this notion, we show that MHC I and MHC I receptors are coexpressed by precursor cells at the earliest stages of retina development, which could enable such coordination...
  48. pmc SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics
    Mihalis Verykokakis
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Immunity 33:203-15. 2010
    ..Our findings reveal that accumulation of NKT-like cells promotes conventional CD8(+) thymocytes to acquire innate lymphocyte characteristics...
  49. pmc Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCR-transgenic mouse model
    Yoshinobu Akiyama
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    J Immunol 186:1442-9. 2011
    ....
  50. doi Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes
    Moutih Rafei
    Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec H3C 3J7, Canada
    J Immunol 187:3133-44. 2011
    ..We concluded that innate TCRαβ(+) CD8 T cells represent a sizeable proportion of normal thymocytes whose development and function differ in many ways from those of conventional CD8 T cells...
  51. doi Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets
    Petter Brodin
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Immunol 188:2218-26. 2012
    ....
  52. pmc ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides
    Takayuki Kanaseki
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Immunol 191:1547-55. 2013
    ..Thus, the optimal pMHC I repertoire is produced by two distinct peptide editing steps in the endoplasmic reticulum. ..
  53. pmc Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes
    Xavier Dervillez
    Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine School of Medicine, Irvine, CA 92697
    J Immunol 191:5124-38. 2013
    ..These findings should guide the development of a safe and effective T cell-based herpes vaccine. ..
  54. pmc MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling
    Tracy J Dixon-Salazar
    Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093
    J Neurosci 34:11844-56. 2014
    ....
  55. pmc Developmental Sculpting of Intracortical Circuits by MHC Class I H2-Db and H2-Kb
    Jaimie D Adelson
    Departments of Biology and Neurobiology and Bio X
    Cereb Cortex 26:1453-63. 2016
    ..Thus, these MHCI proteins regulate sculpting of local cortical circuits and in their absence, the excess connectivity can function as a substrate for cortical plasticity throughout life. ..
  56. pmc An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus
    Lili Chen
    Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    J Immunol 187:6463-72. 2011
    ..These findings demonstrate that class Ib-restricted CD8(+) T cells have the potential to participate in the host immune response to LCMV...
  57. doi The expression pattern of classical MHC class I molecules in the development of mouse central nervous system
    Jiane Liu
    Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Department of Microbiology and Immunology, Medical School, Southeast University, 87 Dingjiaqiao Road, 210009 Nanjing, China
    Neurochem Res 38:290-9. 2013
    ..The investigation of the expression pattern of H-2D(b) at both embryonic and postnatal stages is important for further understanding the physiological and pathological roles of H2-D(b) in the developing CNS...
  58. doi Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway
    Sheng Xu
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, China
    Nat Immunol 13:551-9. 2012
    ..Thus, constitutive MHC class I molecules engage in crosstalk with TLR signaling via the Fps-SHP-2 pathway and control TLR-triggered innate inflammatory responses...
  59. pmc New molecular markers for the distal end of the t-complex and their relationships to mutations affecting mouse development
    T Ebersole
    Department of Zoology, University of Texas, Austin 78712 1064
    Genetics 131:175-82. 1992
    ....
  60. ncbi Aberrant splicing caused by the insertion of the B2 sequence into an intron of the complement C4 gene is the basis for low C4 production in H-2k mice
    S Pattanakitsakul
    Department of Immunobiology, Cancer Research Institute, Kanazawa University, Japan
    J Biol Chem 267:7814-20. 1992
    ....
  61. ncbi Genetic mapping of the t-complex region on mouse chromosome 17 including the Hybrid sterility-1 gene
    J Forejt
    Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague
    Mamm Genome 1:84-91. 1991
    ..The limit of resolution of the cross was 0.27 cM. The map distances have been determined for the DNA loci in the T-H-2 interval and the Hst-1 gene was mapped in close vicinity to the D17Rp17 locus...
  62. ncbi Nucleic acid sequences of the H-2Ks and H-2Ksm1 genes
    K J Hasenkrug
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461
    Immunogenetics 34:60-1. 1991
  63. pmc Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos
    K Abe
    Department of Zoology, University of Texas, Austin 78712 1064
    EMBO J 7:3441-9. 1988
    ..The combined data suggest that the spatial organization of genes in the mammalian genome may not be random...
  64. ncbi Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocks
    M Prochazka
    Jackson Laboratory, Bar Harbor, ME 04609
    Diabetes 38:1446-55. 1989
    ..abstract truncated at 400 words)..
  65. ncbi Analysis of a new class I gene mapping to the Hmt region of the mouse
    K A Brorson
    Division of Biology, California Institute of Technology, Pasadena 91125
    Immunogenetics 30:273-83. 1989
    ..However, unlike the classical class I genes, the Thy19.4 gene maps approximately 1 cm distal to the Tla region of the MHC, in the same region as the gene encoding the Hmt element of the maternally transmitted antigen...
  66. pmc Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation
    J Geliebter
    Mol Cell Biol 6:645-52. 1986
    ..Because the Kbm6 mutation arose in an homozygous mouse these data indicate that the Q4 gene contains the only donor sequence and demonstrates that Q-region gene sequences can interact with the Kb gene to generate variant K molecules...
  67. pmc The molecular organization of the H-2K region of two t-haplotypes: implications for the evolution of genetic diversity
    H Uehara
    EMBO J 6:83-90. 1987
    ....
  68. pmc Polymorphism and linkage of the alpha A-crystallin gene in t-haplotypes of the mouse
    L C Skow
    Genetics 116:107-11. 1987
    ....
  69. ncbi The H-2Kkml mutation: a single nucleotide substitution is responsible for multiple functional differences in a class I MHC molecule
    J M Martinko
    Department of Microbiology, Southern Illinois University, Carbondale 62901 6508
    Mol Immunol 25:267-74. 1988
    ..This information suggests that amino acid 152 is an important part of a T-cell-recognized antigenic determinant on MHC class I antigens...
  70. pmc Mitotic recombination in germ cells generated two major histocompatibility complex mutant genes shown to be identical by RNA sequence analysis: Kbm9 and Kbm6
    J Geliebter
    Proc Natl Acad Sci U S A 83:3371-5. 1986
    ..Such a mechanism probably plays a major role in the generation of diversity in the major histocompatibility complex...
  71. ncbi Gene mapping within the T/t complex of the mouse. IV: The inverted MHC is intermingled with several t-lethal genes
    H S Shin
    Cell 39:573-8. 1984
    ..At the centromeric end the t12 lethal maps between TL and H-2D in the Qa region, and distally the tw5 lethal is inseparable from H-2K...
  72. pmc Complete nucleotide sequence of the murine H-2Kk gene. Comparison of three H-2K locus alleles
    B Arnold
    Nucleic Acids Res 12:9473-87. 1984
    ..We have also identified potentially allele-specific nucleotide sequences of the K genes which might be used as specific DNA probes...
  73. pmc Different exon-intron organization at the 5' part of a mouse class I gene is used to generate a novel H-2Kd-related mRNA
    J L Lalanne
    Proc Natl Acad Sci U S A 80:7561-5. 1983
    ..pH-2d-24 carries an open reading frame encoding a thus-far-undescribed polypeptide product identical to an H-2Kd-molecule, except for the NH2-terminal half of the first domain...
  74. pmc Comparison of nucleotide sequences of mRNAs belonging to the mouse H-2 multigene family
    J L Lalanne
    Nucleic Acids Res 10:1039-49. 1982
    ..Comparison of the sequence indicates a large homology throughout the coding and non-coding regions and suggests the existence of a genetic mechanism which homogenizes nucleotide sequences among genes of the H-2 multigene family...
  75. pmc A cDNA clone containing the entire coding sequence of a mouse H-2Kd histocompatibility antigen
    J L Lalanne
    Nucleic Acids Res 11:1567-77. 1983
    ..Its sequence and overal features are described. They point to the existence of unique properties of DNA sequences associated with the H-2K(d) antigen...
  76. pmc H-2-linked regulation of xenotropic murine leukemia virus expression
    R A Yetter
    Proc Natl Acad Sci U S A 80:505-9. 1983
    ....
  77. pmc Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences
    D H Schulze
    Proc Natl Acad Sci U S A 80:2007-11. 1983
    ....
  78. ncbi Thy-2: a murine thymocyte-brain alloantigen controlled by a gene linked to the major histocompatibility complex
    A W Siadak
    Immunogenetics 12:45-58. 1981
    ..Expression of the Thy-2 alloantigen is controlled by a single semidominant gene located approximately 3 cM to the right of the H-2K locus on chromosome 17...
  79. pmc Transcription of HLA-G transgenes commences shortly after implantation during embryonic development in mice
    A Horuzsko
    Division of Molecular Immunology, National Institute for Medical Research, London
    Immunology 83:324-8. 1994
    ....
  80. ncbi MHC class I genes are not imprinted in the mouse placenta
    J M Drezen
    Department of Immunology, Institut Pasteur, Paris, France
    Immunogenetics 40:62-5. 1994
  81. ncbi PCR-generated cDNA libraries from reduced numbers of mouse oocytes
    F Revel
    Unite de biologie du developpement INRA, Jouy en Josas, France
    Zygote 3:241-50. 1995
    ..008% of the mRNA. The repeatable generation of representative cDNA libraries from reduced numbers of oocytes or embryos should open new opportunities for obtaining genetic information from mammalian preimplantation embryos...
  82. ncbi Sequence, linkage to H2-K, and function of mouse tapasin in MHC class I assembly
    A G Grandea
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Immunogenetics 48:260-5. 1998
    ..Thus, tapasin is a structurally and functionally conserved component of the MHC class I antigen processing pathway...
  83. ncbi HLA-G transgenic mice
    A Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta 30912 2600, USA
    J Reprod Immunol 43:253-61. 1999
    ....
  84. ncbi V beta T cell repertoire of CD8+ splenocytes selected on nonpolymorphic MHC class I molecules
    D Laouini
    Laboratoire de Biologie Moléculaire du Gène, Institut National de la Santé et de la Recherche Médicale U277 Institut Pasteur, Paris, France
    J Immunol 165:6381-6. 2000
    ..This observation implies that BV diversity is positively correlated with the number of CD8(+) cells, even when the number of CD8(+) splenocytes is dramatically reduced (90% in the double knockout mice)...
  85. pmc Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules
    M M Maurice
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:7437-42. 2001
    ....
  86. pmc Dendritic cell maturation overrules H-2D-mediated natural killer T (NKT) cell inhibition: critical role for B7 in CD1d-dependent NKT cell interferon gamma production
    Y Ikarashi
    Unite d immunologie, Departement de Biologie Clinique, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Exp Med 194:1179-86. 2001
    ..These data point to a unique regulatory role of DCs in NKT cell innate immune responses and suggest that H-2 class Ia and Ib pathways differentially control NKT cell recognition of DC antigens...
  87. pmc Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells
    William C Kieper
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:1533-9. 2002
    ..Since these cell are rare in normal IL-15(-) mice, the dependency of memory phenotype CD8+ cells on IL-15 can be overcome by overexpression of IL-7...
  88. ncbi Increased hepatic iron in mice lacking classical MHC class I molecules
    Elsa M Cardoso
    Molecular Immunology and Immunobiology, Institute for Molecular and Cell Biology, Paris, France
    Blood 100:4239-41. 2002
    ..These results demonstrate for the first time that classical MHC-I molecules could be involved in the regulation of iron metabolism and contribute to the established genotype/phenotype discrepancies seen in HH...
  89. ncbi Competition between MHC class I alleles for cell surface expression alters CTL responses to influenza A virus
    Sophie Tourdot
    Department of Immunology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, UK
    J Immunol 169:5615-21. 2002
    ..Therefore, certain MHC class I molecules compete with each other for cell surface expression, and the resulting low cell surface expression of specific alleles can lead to a severe reduction in the ability to generate a CTL response...
  90. pmc CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis
    Xue Feng Bai
    Division of Cancer Immunology, Department of Pathology, Ohio State University Medical Center, 129 Hamilton Hall, 1645 Neil Ave, Columbus 43210, USA
    J Exp Med 200:447-58. 2004
    ....
  91. ncbi Cutting edge: antibody production to pneumococcal polysaccharides requires CD1 molecules and CD8+ T cells
    Lisa J Kobrynski
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 174:1787-90. 2005
    ....
  92. pmc CD8+ T cells require perforin to clear West Nile virus from infected neurons
    Bimmi Shrestha
    Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, Box 8051, St Louis, MO 63110, USA
    J Virol 80:119-29. 2006
    ..Taken together, our data suggest that despite the risk of immunopathogenesis, CD8+ T cells use a perforin-dependent mechanism to clear WNV from infected neurons...
  93. pmc Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases
    Gobardhan Das
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    J Exp Med 203:2603-11. 2006
    ..These findings provide direct evidence that CD8+ ILLs are sufficient to initiate and mediate autoimmune diseases...
  94. ncbi Recognition of H-2K(b) by Ly49Q suggests a role for class Ia MHC regulation of plasmacytoid dendritic cell function
    Lee Hwa Tai
    Institut de recherches cliniques de Montreal IRCM, Laboratory of Molecular Immunology, Universite de Montreal, Montreal, Quebec, Canada
    Mol Immunol 44:2638-46. 2007
    ..MHC recognition capability by pDC has important implications for the role of this cell type during innate immune responses...
  95. pmc CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype
    Yuwen Zhu
    Department of Dermatology, Johns Hopkins University School of Mediicne, 1550 Orleans Street, Baltimore, MD 21231, USA
    Blood 109:4882-9. 2007
    ..CD137-mediated proliferation of memory T cells is directly through CD137 on T cells and does not require IL-15 and IFN-gamma. Our results define a new role of CD137 signal in the growth of memory T cells...
  96. pmc Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus
    Adrian Erlebacher
    Department of Pathology, Experimental Pathology Program, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Clin Invest 117:1399-411. 2007
    ..The pronounced degree of T cell ignorance of the fetus also has implications for the pathophysiology of immune-mediated early pregnancy loss...
  97. pmc A constant affinity threshold for T cell tolerance
    Dieter Naeher
    Laboratory of Transplantation Immunology, Department of Research, University Hospital, 4031 Basel, Switzerland
    J Exp Med 204:2553-9. 2007
    ..The affinity threshold for self-tolerance appears to be a constant for cytotoxic T lymphocytes...
  98. doi H-2Kb-restricted CTL epitopes from mouse heparanase elicit an antitumor immune response in vivo
    Xu Dong Tang
    Institute of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, PR China
    Cancer Res 68:1529-37. 2008
    ..These epitopes may serve as valuable tools for the preclinical evaluation of vaccination strategies...
  99. pmc CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors
    Angela M Tatum
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Immunol 181:4406-17. 2008
    ..Finally, we show that production of IFN-gamma, but not perforin or TNF-alpha, by the donor lymphocytes is critical for control of autochthonous brain tumors...
  100. pmc Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis
    Charles Kwok chong Li
    Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Am J Pathol 175:1030-40. 2009
    ..This novel model has important implications for our understanding of muscle pathology in dermatomyositis of both adults and children...
  101. pmc NK gene complex and chromosome 19 loci enhance MHC resistance to murine cytomegalovirus infection
    Michael D Stadnisky
    Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Immunogenetics 61:755-64. 2009
    ..Importantly, both chromosome 6 and 19 QTLs contribute to virus control independent of H-2(k). Altogether, MHC and non-MHC MCMV-resistance QTL contribute in early resistance to MCMV infection in this genetic system...

Research Grants2

  1. Activation of innate antiviral defenses by LTbetaR
    CHRISTOPHER BENEDICT; Fiscal Year: 2005
    ..abstract_text> ..
  2. CD8 T Lymphocyte Regulation of EAE Disease Phenotype
    Michael Carrithers; Fiscal Year: 2008
    ..unreadable] [unreadable]..