H2-Ab1

Summary

Gene Symbol: H2-Ab1
Description: histocompatibility 2, class II antigen A, beta 1
Alias: AI845868, Abeta, H-2Ab, H2-Ab, I-Abeta, IAb, Ia-2, Ia2, Rmcs1, histocompatibility 2, class II antigen A, beta 1, H-2 class II histocompatibility antigen, A beta chain, MHC class II H2-IA-beta-psi, MHC class II antigen A beta, major histocompatibility complex class II beta chain, response to metastatic cancers 1
Species: mouse

Top Publications

  1. pmc Characterization of the early stages of thymic NKT cell development
    Kamel Benlagha
    Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 202:485-92. 2005
  2. pmc TIM-3: a novel regulatory molecule of alloimmune activation
    Olaf Boenisch
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
    J Immunol 185:5806-19. 2010
  3. ncbi Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
    J Katz
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Strasbourg, France
    Eur J Immunol 23:3358-60. 1993
  4. pmc Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
    Jung Hyun Park
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 11:257-64. 2010
  5. pmc CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice
    Sarah E Weber
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 186:432-42. 2011
  6. pmc B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse
    I F McKenzie
    J Exp Med 150:1323-38. 1979
  7. ncbi Timing and casting for actors of thymic negative selection
    N Dautigny
    Institut National de la Sante et de la Recherche Medicale, Unit 345, Institut Necker, Paris, France
    J Immunol 162:1294-302. 1999
  8. doi CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus
    Xi He
    Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
    Immunity 28:346-58. 2008
  9. ncbi Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection
    Devon J Shedlock
    Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Immunol 170:2053-63. 2003
  10. ncbi Antigen presentation and T cell development in H2-M-deficient mice
    W P Fung-Leung
    R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    Science 271:1278-81. 1996

Research Grants

  1. The vital role of BAFF in the development of SLE
    William Stohl; Fiscal Year: 2010
  2. Analysis of CD81-PGRL complex on T cells
    STEPHEN CHAPES; Fiscal Year: 2007
  3. Treg Migration in GVHD
    Jonathan Serody; Fiscal Year: 2009
  4. Pneumococcal immunization through a novel mechanism
    Richard Malley; Fiscal Year: 2010
  5. Mechanisms Involved in T cell trafficking in GVHD
    Jonathan Serody; Fiscal Year: 2007
  6. Multimodality Therapy for Metastatic Breast Cancer
    Jonathan Serody; Fiscal Year: 2006
  7. Pneumolysin, Innate and Acquired Immunity to Pneumococci
    Richard Malley; Fiscal Year: 2005
  8. Viral Decoy Receptors
    Daved Fremont; Fiscal Year: 2007
  9. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2007
  10. Regulation of Lineage Specificity of CD4 Silencing
    Yong Rui Zou; Fiscal Year: 2008

Detail Information

Publications159 found, 100 shown here

  1. pmc Characterization of the early stages of thymic NKT cell development
    Kamel Benlagha
    Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 202:485-92. 2005
    ..1neg CD4 cells. These findings identify the HSAhigh CD4+ stage as a potential branchpoint between NKT and conventional T lineages and between the CD4 and DN NKT sublineages...
  2. pmc TIM-3: a novel regulatory molecule of alloimmune activation
    Olaf Boenisch
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
    J Immunol 185:5806-19. 2010
    ..In summary, TIM-3 is a key regulatory molecule of alloimmunity through its ability to broadly modulate CD4(+) T cell differentiation, thus recalibrating the effector and regulatory arms of the alloimmune response...
  3. ncbi Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
    J Katz
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Strasbourg, France
    Eur J Immunol 23:3358-60. 1993
    ..We question this interpretation because NOD mice lacking MHC class I molecules, hence CD8+ T cells, do not display even insulitis when expected...
  4. pmc Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
    Jung Hyun Park
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 11:257-64. 2010
    ....
  5. pmc CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice
    Sarah E Weber
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 186:432-42. 2011
    ....
  6. pmc B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse
    I F McKenzie
    J Exp Med 150:1323-38. 1979
    ..Serological analysis with a battery of H-2b, Iab, and other Ia sera, both by cytotoxicity, rosetting, and also by absorption analysis, indicated no alteration in H-..
  7. ncbi Timing and casting for actors of thymic negative selection
    N Dautigny
    Institut National de la Sante et de la Recherche Medicale, Unit 345, Institut Necker, Paris, France
    J Immunol 162:1294-302. 1999
    ..Finally, we show involvement in opposing directions for p59fyn and SHP-1 molecules in signaling for thymic negative selection...
  8. doi CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus
    Xi He
    Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
    Immunity 28:346-58. 2008
    ..We propose a silencer-dependent model of lineage choice, whereby inactivation of the DRE silencer by a strong TCR signal leads to CD4 commitment, whereas continued silencer activity leads to CD8 commitment...
  9. ncbi Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection
    Devon J Shedlock
    Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Immunol 170:2053-63. 2003
    ....
  10. ncbi Antigen presentation and T cell development in H2-M-deficient mice
    W P Fung-Leung
    R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    Science 271:1278-81. 1996
    ..Their CD4+ cells were unresponsive to self H2-M-deficient antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs. H2-M-deficient APCs failed to elicit proliferative responses from wild-type T cells...
  11. ncbi HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice
    Kay E Black
    Department of Immunology, Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, 220 1st Street SW, Rochester, MN 55905, USA
    J Immunol 169:5595-600. 2002
    ..These data suggest that this HLA class II transgenic murine model of gluten sensitivity may provide insight into the initiation of the MHC class II-restricted gluten sensitivity in celiac disease...
  12. pmc Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells
    Rafal Pacholczyk
    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Immunity 27:493-504. 2007
    ..Our results show that high-affinity, autoreactive TCRs are rare on all CD4+ T cells and suggest that selecting self-peptide is different from the peptide that activates the same regulatory T cells in the periphery...
  13. ncbi Mice lacking MHC class II molecules
    D Cosgrove
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire de Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
    Cell 66:1051-66. 1991
    ..In short, the class II-negative mice have confirmed some old ideas about lymphocyte differentiation, but have provided some surprises...
  14. ncbi Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice
    M J Grusby
    Department of Cancer Biology, Harvard School of Public Health, Boston, MA
    Science 253:1417-20. 1991
    ..These results provide genetic evidence that class II molecules are required for the maturation and function of mature CD4+ T cells...
  15. ncbi The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex
    M Hattori
    Science 231:733-5. 1986
    ..In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region...
  16. pmc Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant
    L Mengle-Gaw
    J Exp Med 160:1184-94. 1984
    ....
  17. ncbi In the absence of a CD40 signal, B cells are tolerogenic
    J E Buhlmann
    Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Immunity 2:645-53. 1995
    ..These studies provide insights into the tolerogenic capacity of resting B cells and outlines a practical approach to exploit this function...
  18. ncbi The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif
    R Lindstedt
    R W Johnson Pharmaceutical Research Institute, Scripps Research Institute, La Jolla, California 92037, USA
    Immunity 3:561-72. 1995
    ..Thus, the targeting motif of H2-M appears to be supplementary, rather than essential for class II-peptide association...
  19. ncbi Mice lacking the MHC class II-associated invariant chain
    S Viville
    Laboratorie de Génétique Moléculaire des Eucaryotes du CNRS, Strasbourg, France
    Cell 72:635-48. 1993
    ..Consequently, mutant cells present protein antigens very poorly and mutant mice are deficient in producing and at negatively selecting CD4+ T cells...
  20. ncbi Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection
    H Suzuki
    Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Immunity 2:413-25. 1995
    ..These results are incompatible with current concepts and require a new perspective on lineage commitment and positive selection, which we refer to as asymmetric commitment...
  21. pmc Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins
    S Hou
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    J Virol 69:1429-34. 1995
    ..As found previously with CD4-depleted H-2b mice, the development of Sendai virus-specific CD8+ T-cell-mediated immunity is not compromised by the absence of a concurrent class II major histocompatibility complex-restricted response...
  22. pmc Mice lacking major histocompatibility complex class I and class II molecules
    M J Grusby
    Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115
    Proc Natl Acad Sci U S A 90:3913-7. 1993
    ..Taken together, these results emphasize the plasticity of the immune system and suggest that MHC-deficient mice may be useful for examining compensatory mechanisms in severely immunocompromised animals...
  23. ncbi The repertoire of T cells shaped by a single MHC/peptide ligand
    L Ignatowicz
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, University of Colorado Health Sciences Center, Denver, 80206, USA
    Cell 84:521-9. 1996
    ..T cells that mature in thymuses expressing a single MHC/peptide ligand react frequently with foreign MHC, suggesting that the repertoire of alpha beta receptors may be more biased toward reaction with MHC than was previously thought...
  24. ncbi Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway
    T Miyazaki
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Universite Louis Pasteur, France
    Cell 84:531-41. 1996
    ..Peripheral T cells reacted strongly to splenocytes from syngeneic wild-type mice, no doubt reflecting the unique peptide complement carried by class II molecules in mutant animals...
  25. ncbi H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection
    W D Martin
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cell 84:543-50. 1996
    ..Overall, this phenotype establishes an important role for H2-M in regulating MHC class II function in vivo and supports the notion that self-peptides contribute to the specificity of T cell positive selection...
  26. pmc The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
    A Itano
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
    J Exp Med 183:731-41. 1996
    ..We discuss these results in terms of current models for CD4 and CD8 lineage commitment...
  27. pmc HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis
    K Ito
    Department of Inflammation and Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, New Jersey 07110, USA
    J Exp Med 183:2635-44. 1996
    ..Non-Tg mice immunized with either PLP175-192 or MBP87-106 did not develop EAE. These results demonstrated that a human MHC class II binding site alone can confer susceptibility to an experimentally induced murine autoimmune disease...
  28. pmc Infection of class II-deficient mice by the DA strain of Theiler's virus
    L Fiette
    Unite des Virus Lents, URA 1157 Centre National de la Recherche Scientifique, Institut Pasteur, France
    J Virol 70:4811-5. 1996
    ..However, these foci are smaller and contain fewer demyelinated axons than those observed in susceptible SJL/J or beta2m-/- mice...
  29. pmc Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes
    S Tourne
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, University Louis Pasteur 1, Strasbourg, France
    Proc Natl Acad Sci U S A 94:9255-60. 1997
    ....
  30. pmc Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo
    S Kovats
    Department of Immunology, University of Washington School of Medicine, Seattle 98195, USA
    J Exp Med 187:245-51. 1998
    ..These findings are consistent with the idea that H-2M functions as a chaperone in the peptide loading of class II molecules in vivo...
  31. pmc HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells
    V P Dave
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 95:8187-92. 1998
    ..This is the first genetic defect of its kind to be described in the mouse and may prove highly informative in understanding the molecular pathways underlying lineage commitment...
  32. pmc Visualization of CD4/CD8 T cell commitment
    S Chan
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Strasbourg, 67404 Illkirch Cedex, France
    J Exp Med 188:2321-33. 1998
    ..Finally, we found no evidence of a CD4 default pathway...
  33. pmc Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity
    J Kehren
    Institut National de la Santé et de la Recherche Médicale INSERM U503, Faculte Laennec, F 69372 Lyon Cedex 08, France
    J Exp Med 189:779-86. 1999
    ..Thus, cytotoxic CD8(+) T cells, commonly implicated in the host defence against tumors and viral infections, could also mediate harmful delayed-type hypersensitivity reactions...
  34. ncbi Peptide dependency of alloreactive CD4+ T cell responses
    S K Mendiratta
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Int Immunol 11:351-60. 1999
    ..APC from these mice were used as targets and stimulators for alloreactive CD4+ T cells. Results demonstrated that the vast majority of CD4+ alloreactive T cells recognize MHC class II molecules in a peptide-dependent fashion...
  35. pmc Mice lacking all conventional MHC class II genes
    L Madsen
    Department of Clinical Immunology, Rigshospitalet, 2200 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 96:10338-43. 1999
    ..These mice feature immune system perturbations like those of Aalpha and Abeta knockout animals, notably a dearth of CD4(+) lymphocytes in the thymus and spleen...
  36. ncbi Regulation of lineage commitment distinct from positive selection
    R Keefe
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 286:1149-53. 1999
    ..However, neither TCR-mediated signaling nor positive selection is impaired. Thus, the HD mutation provides genetic evidence that lineage commitment may be mechanistically distinct from positive selection...
  37. ncbi NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells
    M C Coles
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    J Immunol 164:2412-8. 2000
    ..1+ T cells or are induced to proliferate after having left the thymus. The results indicate that NK1.1+ T cells, like conventional T cells, arise in the thymus where they are selected by interactions with restricting molecules...
  38. ncbi Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection
    C Pope
    Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 166:3402-9. 2001
    ..Overall, the results point to novel pathways of tissue-specific regulation of primary and memory antimicrobial CD8 T cell responses...
  39. pmc The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families
    S H Park
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Exp Med 193:893-904. 2001
    ..Altogether, these findings imply that lipid recognition by CD1d-restricted T cells may have largely evolved as an innate rather than an adaptive arm of the mouse immune system...
  40. ncbi Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage
    Y R Zou
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Genet 29:332-6. 2001
    ..The epigenetic inheritance of the silenced CD4 locus was not affected by the inhibition of DNA methylation or histone deacetylation, and may thus involve other mechanisms that ensure a stable state of gene expression...
  41. ncbi A conditional null allele of the major histocompatibility IA-beta chain gene
    Kahoko Hashimoto
    Institute of Molecular Medicine and Genetics and Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Genesis 32:152-3. 2002
  42. ncbi A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development
    B J Fowlkes
    Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:1817-21. 2002
    ..We suggest that the discrepancies in previous reports of Notch1IC transgenic mice are due to differences in the propensity of the two different transgenic lines to develop tumors...
  43. ncbi T-cell engagement of dendritic cells rapidly rearranges MHC class II transport
    Marianne Boes
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 418:983-8. 2002
    ..We propose that such tubulation serves to facilitate the ensuing T-cell response...
  44. pmc Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice
    Gabrielle T Belz
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:12388-93. 2002
    ..These findings are consistent with mathematical models that predict virus-host dynamics in this, and other, models of infection...
  45. pmc On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells
    Bruno Martin
    Institut National de la Santé et de la Recherche Médicale U561, Hopital Saint Vincent de Paul, 75014 Paris, France
    Proc Natl Acad Sci U S A 100:6021-6. 2003
    ..Nevertheless, interactions with classical MHC class II molecules are required for CD4(+) T cells to survive in CD8(+) T-cell-containing mice...
  46. ncbi Characterization of HLA DR2 and DQ8 transgenic mouse with a new engineered mouse class II deletion, which lacks all endogenous class II genes
    S Cheng
    Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Autoimmun 21:195-9. 2003
    ..However, these mice carry the functional mouse Eb gene from the Abeta(0/0) construct and could express Ebeta/DRalpha(Ealpha) molecules and shape the T cell repertoire in these mice...
  47. ncbi CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity
    Maria P Lemos
    Department of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA
    J Immunol 171:5077-84. 2003
    ..These findings indicate that DCs are not only key initiators of the primary response, but provide all of the necessary cognate interactions to control CD4(+) T cell fate during the primary immune response...
  48. pmc CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection
    Joseph C Sun
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 5:927-33. 2004
    ..We conclude that in the context of an acute infection, CD4(+) T cells are required only during the maintenance phase of long-lived memory CD8(+) T cells...
  49. ncbi Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb
    Srividya Subramanian
    Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Immunol 175:1062-72. 2005
    ..Sle1 Sles1)F(1)s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene...
  50. ncbi Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity
    Sophia D Sarafova
    Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Immunity 23:75-87. 2005
    ..This study demonstrates that termination of coreceptor transcription during positive selection promotes CD8-lineage fate, regardless of TCR specificity or coreceptor protein identity...
  51. ncbi Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance
    Michiko Shimoda
    Molecular Immunology Program and Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 176:6503-11. 2006
    ..Thus, our findings lend support to the proposal that Treg cell homeostasis depends on a delicate balance with a population of self-reactive IL-2-producing CD4+CD25+ cells which are themselves at least in part MHC-II-dependent...
  52. ncbi Inhibition of MHC class II expression and immune responses by c-MIR
    Mari Ohmura-Hoshino
    Laboratory for Infectious Immunity, The Institute of Physical and Chemical Research RIKEN, Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Immunol 177:341-54. 2006
    ..To our knowledge, c-MIR is the first example of an E3 that is capable of inhibiting MHC II expression. Our findings suggest that c-MIR might potently regulate immune responses in vivo...
  53. ncbi Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination
    Jeoung Sook Shin
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, Connecticut 06520 8002, USA
    Nature 444:115-8. 2006
    ..Dendritic cells thus exhibit a unique ability to regulate MHC II surface expression by selectively controlling MHC II ubiquitination...
  54. ncbi Regulatory function of CD4+CD25+ T cells from Class II MHC-deficient mice in contact hypersensitivity responses
    Danielle D Kish
    Department of Immunology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195 0001, USA
    J Leukoc Biol 82:85-92. 2007
    ..These results identify functional CD4+CD25+ Treg in Class II MHC-/- mice, which restrict hapten-specific CD8+ T cell priming and the magnitude of CHS responses...
  55. pmc c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3
    Diane Maurice
    Institute of Cancer Research, Cancer Research UK Centre for Cell and Molecular Biology, London, UK
    EMBO J 26:3629-40. 2007
    ..We show that Gata3 is a direct target of c-Myb, and propose that c-Myb is an important regulator of Gata3, required for transduction of the T-cell receptor signal for subsequent helper cell lineage differentiation...
  56. pmc The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 204:1945-57. 2007
    ..These results indicate that Runx proteins have important roles at multiple stages of T cell development and in the homeostasis of mature T cells...
  57. doi Intercellular MHC transfer between thymic epithelial and dendritic cells
    Virginie Millet
    Aix Marseille Universite, Faculte des Sciences de Luminy, Centre d immunologie de Marseille Luminy, Marseille, France
    Eur J Immunol 38:1257-63. 2008
    ..This novel mode of transfer of MHC-associated, epithelial cell-derived self-antigens onto DC might participate to the process of negative selection in the thymic medulla...
  58. doi Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Nat Immunol 9:1113-21. 2008
    ..Our results show how an initial lineage-specification signal can be amplified and stabilized during the lineage-commitment process...
  59. pmc Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells
    Susan Johnson
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australiaia
    Immunity 30:218-27. 2009
    ..Thus, CD40L upregulation on DCs promoted optimal priming of CD8(+) T cells without CD4(+) T cells, providing a mechanism by which pathogens may elicit helper-independent CTL immunity...
  60. doi Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment
    Lee Kim Swee
    Departement Biomedizin Basel, University of Basel, Switzerland
    Blood 113:6277-87. 2009
    ..It also reinforces the relevance of FLT3L treatment in GVHD by its ability to increase both the number of tolerizing DCs and NTregs...
  61. doi Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells
    Mari Ohmura-Hoshino
    Laboratory for Infectious Immunity, RIKENResearch Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa, Japan
    J Immunol 183:6893-7. 2009
    ..These results suggest that the accumulation of MHC II resulting from loss of ubiquitination caused cDC abnormality; therefore, MARCH-I may function as a housekeeper of cDC in the steady state...
  62. pmc The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes
    Shinya Sakaguchi
    Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    Nat Immunol 11:442-8. 2010
    ..MAZR bound the silencer of the gene encoding Th-POK, which indicated direct regulation of this locus by MAZR. Thus, MAZR is part of the transcription factor network that regulates the CD8 lineage differentiation of DP thymocytes...
  63. doi Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance
    Maria Hinterberger
    Institute for Immunology, Ludwig Maximilians Universitat, Munich, Germany
    Nat Immunol 11:512-9. 2010
    ..Our data document an autonomous contribution of mTECs to both dominant and recessive mechanisms of CD4(+) T cell tolerance and support an avidity model of T(reg) cell development versus deletion...
  64. pmc Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus
    Stephanie K Dougan
    1 Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA 2
    Nature 503:406-9. 2013
    ..We propose that influenza targets and kills influenza-specific B cells in the lung, thus allowing the virus to gain purchase before the initiation of an effective adaptive response. ..
  65. pmc The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique
    H Acha-Orbea
    Proc Natl Acad Sci U S A 84:2435-9. 1987
    ..We suggest that the unique structure of the first external I-A beta chain domain is a major determinant in the disease susceptibility that maps to the major histocompatibility complex of the nonobese diabetic mouse...
  66. ncbi Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice
    J Liu
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    Diabetes 48:469-77. 1999
    ....
  67. pmc MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania major
    Maria P Lemos
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Exp Med 199:725-30. 2004
    ..major infection using a mouse model in which MHC II, I-Abeta(b), expression is restricted to CD11b+ and CD8alpha+ dendritic cells (DCs)...
  68. ncbi Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes
    Takehito Sato
    Department of Immunology, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259 1193, Japan
    Immunity 22:317-28. 2005
    ....
  69. ncbi IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
    Matthew A Burchill
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 178:280-90. 2007
    ..Finally, STAT5 binds to the promoter of the foxp3 gene suggesting that IL-2Rbeta-dependent STAT5 activation promotes Treg differentiation by regulating expression of foxp3...
  70. doi Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development
    Ruka Setoguchi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Science 319:822-5. 2008
    ..Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system...
  71. pmc ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
    Takeshi Egawa
    Molecular Pathogenesis Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nat Immunol 9:1131-9. 2008
    ..Our results suggest that MHC class II-selected thymocytes are directed toward the CD4(+) lineage independently of ThPOK but require ThPOK to prevent Runx-dependent differentiation toward the CD8(+) lineage...
  72. ncbi Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease
    H R Chakkalath
    Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Infect Dis 171:1302-8. 1995
    ..major and that in the absence of these cells and molecules, such mice can transiently control infection with L. major but are unable to resolve such infections...
  73. ncbi Another view of the selective model of thymocyte selection
    S H Chan
    Laboratoire de Genetique Moleculaire, Eucaryotes du Centre National de la Recherche Scientifique, Faculte de Medecine, Strasbourg, France
    Cell 73:225-36. 1993
    ....
  74. ncbi Complete characterization of the expressed immune response genes in Biozzi AB/H mice: structural and functional identity between AB/H and NOD A region molecules
    G Y Liu
    Cambridge University Department of Pathology, UK
    Immunogenetics 37:296-300. 1993
  75. ncbi Antiviral immune responses of mice lacking MHC class II or its associated invariant chain
    M Battegay
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland
    Cell Immunol 167:115-21. 1996
    ..This suggests that local protein concentrations reached during viral infection in the host are high enough to override the Ii deficiency of antigen-presenting cells in vivo...
  76. pmc HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis
    D S Bradley
    Department of Immunology, Mayo Clinic and Medical School, Rochester, Minnesota 55905, USA
    J Clin Invest 100:2227-34. 1997
    ..These studies support a role for HLA-DQ polymorphism in human RA...
  77. ncbi Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells
    Mariëlle C Haks
    Division of Basic Sciences, Immunobiology Working Group, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 170:2853-61. 2003
    ..Taken together these data suggest that cell-autonomous, ligand-independent signaling is primarily a property of the thymocytes in which pre-TCR signaling occurs...
  78. ncbi In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla
    Mariam Nasreen
    Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan
    J Immunol 171:3394-400. 2003
    ....
  79. ncbi The expression of I-A correlates with the uptake of interferon-gamma by macrophages
    A Celada
    La Jolla Cancer Research Foundation, CA 92037
    Eur J Immunol 19:205-8. 1989
    ....
  80. ncbi Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d
    M Malissen
    Science 221:750-4. 1983
    ..Sequence comparisons have been made to other proteins involved in immune responses and the consequent implications for the evolutionary relationships of these genes are discussed...
  81. ncbi Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50
    C T Cady
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 165:1790-8. 2000
    ..Direct stimulation by ligands resembling pE50Y50 may thus selectively evoke contributions of gamma delta T cells to the host response...
  82. ncbi Epitope affinity for MHC class I determines helper requirement for CTL priming
    A Franco
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Nat Immunol 1:145-50. 2000
    ..Depending on the epitope, one source of help was much more efficient than the other...
  83. ncbi Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic mice
    S P Chapoval
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 108:764-71. 2001
    ..Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy...
  84. ncbi Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade
    A Yamada
    Transplantation Unit, Surgical Services, Massachusetts General Hospital, Boston, MA 02114, USA
    J Immunol 167:5522-6. 2001
    ..These results suggest that an active CD4(+) response through the indirect pathway is necessary for costimulatory blockade to be effective in prolonging allograft survival...
  85. ncbi A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    Christine Bourgeois
    INSERM U345, Institut Necker, 156 rue de Vaugirard, F 75730 Paris Cedex 15, France
    Science 297:2060-3. 2002
    ..These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation...
  86. pmc Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice
    Thai M Cao
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:11571-6. 2003
    ..Our results likely extend to all serologically MHC-matched mouse strains used in modern research and highlight the profound and variable influence that non-MHC genetic determinants can have in dictating outcome after HCT...
  87. ncbi Helper requirements for generation of effector CTL to islet beta cell antigens
    Georg M N Behrens
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 172:5420-6. 2004
    ..This provides insight into the helper requirements for adoptive transfer immunotherapy of tumors and suggests key points for inhibition of CTL-mediated autoimmunity...
  88. ncbi Critical role of inducible costimulator signaling in the development of arteriosclerosis
    Hisanori Kosuge
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arterioscler Thromb Vasc Biol 26:2660-5. 2006
    ..However, the effect of costimulatory molecules on the formation of neointimal hyperplasia has not been fully elucidated. We examined the role of the ICOS pathway in SMC proliferation...
  89. ncbi Mesenchymal cells are required for functional development of thymic epithelial cells
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:953-64. 2007
    ..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
  90. pmc Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice
    Jonathan A Hill
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Exp Med 205:967-79. 2008
    ..These observations directly implicate citrullinated fibrinogen as arthritogenic in the context of RA-associated MHC class II molecules...
  91. pmc Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection
    Wendy A Szymczak
    Division of Infectious Diseases, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Infect Immun 78:2125-37. 2010
    ..Furthermore, CD4(+) T cells had a deleterious impact on immunity in infected CCR2(-/-) mice...
  92. pmc Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains
    Sanjay Khandelwal
    Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:35303-10. 2010
    ....
  93. pmc Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses
    Botond Z Igyarto
    Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunity 35:260-72. 2011
    ..Langerin(+) dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses...
  94. ncbi Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes
    E Choi
    Science 221:283-6. 1983
    ..The differences were found to be a series of short alterations clustered in the amino terminal half of the polypeptide...
  95. ncbi Mechanisms by which the I-ABM12 mutation influences susceptibility to experimental myasthenia gravis: a study in homozygous and heterozygous mice
    P I Karachunski
    Department of Biochemistry, College of Biological Sciences, University of Minnesota, St Paul 55108, USA
    Scand J Immunol 42:215-25. 1995
    ..This is probably related to the absence of CD4+ cells sensitized to epitopes within the sequence T alpha 150-160, consequent to the inability of the I-Abm12 molecule to present this sequence...
  96. ncbi Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infection
    C H Ladel
    Department of Immunology, University of Ulm, Germany
    J Immunol 153:3116-22. 1994
    ..monocytogenes and point to the necessity of a coordinated interaction between CD8 and CD4 alpha beta T cells (and probably gamma delta T cells) in anti-L. monocytogenes resistance...
  97. ncbi Molecular analysis of the pathogenesis of autoimmune insulitis in NOD mice
    Y Koide
    Department of Microbiology Immunology, Hamamatsu University School of Medicine, Japan
    Tohoku J Exp Med 173:157-70. 1994
    ..Of the diabetes-susceptibility genes, only in the case of Idd-1 is there any evidence for the identity of the gene products. ILI mice should provide more information on the products of the other diabetes-susceptibility genes of NOD mice...
  98. ncbi The contribution of I-Abm12 to phenotypic and functional alterations among T-cell subsets in NZB mice
    M Naiki
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, School of Medicine, Davis 95616
    J Autoimmun 6:131-43. 1993
    ..C-H-2bm12 mice compared to C57BL/6 (H-2b) mice. These data further highlight the influence of I-A on autoimmunity and in particular the influence of the bm12 mutation on altering the natural history of disease expression in NZB mice...
  99. ncbi Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location
    J Hess
    Department of Immunology, University of Ulm, Germany
    J Immunol 156:3321-6. 1996
    ..typhimurium SL7207 Hlys and control strains did not differ in beta 2m-/- mutants. This finding argues against direct correlation of cytosolic location of S. typhimurium SL7207 Hlys with CD8+ T cell dependency of protection...
  100. ncbi Allospecific cytotoxic T cells generated from beta 2m-/- mice in primary MLC: analysis of activation requirements, specificity, and phenotype
    E Lamouse-Smith
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Cell Immunol 179:107-15. 1997
    ..This phenotypic variability of beta 2m-/- CTL generated in primary MLC reveals the diversity of CTL precursors that develop in vivo in the absence of MHC Class I...

Research Grants21

  1. The vital role of BAFF in the development of SLE
    William Stohl; Fiscal Year: 2010
    ..abstract_text> ..
  2. Analysis of CD81-PGRL complex on T cells
    STEPHEN CHAPES; Fiscal Year: 2007
    ..The coordinated effect of CD81, PGRL and EP3 on T cell integrin activity measured by adhesion to or motility on ICAMs. ..
  3. Treg Migration in GVHD
    Jonathan Serody; Fiscal Year: 2009
    ..The overall goals of this work are to provide a better understanding of the mechanism of activity of Treg cells prior to a clinical trial evaluating their effects in blocking GVHD. ..
  4. Pneumococcal immunization through a novel mechanism
    Richard Malley; Fiscal Year: 2010
    ..abstract_text> ..
  5. Mechanisms Involved in T cell trafficking in GVHD
    Jonathan Serody; Fiscal Year: 2007
    ..We will evaluate if small peptides that could be used clinically are effective in blocking the occurrence of GVHD as a prelude to their use in phase I clinical trials. ..
  6. Multimodality Therapy for Metastatic Breast Cancer
    Jonathan Serody; Fiscal Year: 2006
    ..The long-term goals of this work are to evaluate safe and effective therapies that induce a complete remission for the treatment of women with metastatic breast cancer. ..
  7. Pneumolysin, Innate and Acquired Immunity to Pneumococci
    Richard Malley; Fiscal Year: 2005
    ..The establishment of a link between the innate and the acquired arm of the immune response to pneumococcus may provide a better understanding of the mechanisms by which immunity to pneumococcus is acquired. ..
  8. Viral Decoy Receptors
    Daved Fremont; Fiscal Year: 2007
    ..abstract_text> ..
  9. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2007
    ..chaffeensis and other closely related organisms. ..
  10. Regulation of Lineage Specificity of CD4 Silencing
    Yong Rui Zou; Fiscal Year: 2008
    ..Here, we will determine whether the level of nuclear CBFbeta proteins in CD4+ and CD8+ T cells may affect CD4 silencing, by overexpression or RNAi blocking experiments. ..
  11. Basal Ig Signaling and Receptor Editing
    Michael Farrar; Fiscal Year: 2009
    ..abstract_text> ..
  12. The role of TNF receptor family in intestinal GVHD
    GERI BROWN; Fiscal Year: 2004
    ..abstract_text> ..
  13. Immunological control of a persistent viral infection
    Sally R Sarawar; Fiscal Year: 2010
    ..The results obtained may have broader significance in understanding the mechanisms controlling T cell activation or tolerance, in general. ..
  14. CHEMOKINES IN THE IMMUNE RESPONSE TO A VIRAL INFECTION
    Sally Sarawar; Fiscal Year: 2002
    ..3) The role of the CXCR2 chemokine receptor homologue in viral pathogenesis will be determined using a mutant virus in which the gene encoding the CXCR2 homologue has been inactivated. ..
  15. Natural IgM antilymphocyte autoantibodies inhibit HIV-1
    PETER LOBO; Fiscal Year: 2003
    ..A successful outcome with the proposed studies could better our understanding on pathogenesis of H1V-1 infection and may provide strategies to prolong the asymptomatic state after HIV-1 infection. ..
  16. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  17. Gene expression in non-functional CD8 T cells
    Sally Sarawar; Fiscal Year: 2005
    ..The data are likely to lead to a new understanding of how CD8 T cells function in the control of persistent viral infections and mechanisms of CD8 T cell activation. ..
  18. APOPTOSIS-MODIFIED SELF ANTIGEN IN RHEUMATIC DISEASE
    Eric Greidinger; Fiscal Year: 2002
    ..In the future, this work may lead to the development of specific immunotherapy strategies for the treatment of Ul-70kDa-associated rheumatic disorders. ..
  19. Interaction between influenza virus and H. influenzae
    Sally Sarawar; Fiscal Year: 2007
    ..This could be particularly important during an influenza pandemic and may be more broadly applicable to other respiratory viruses. [unreadable] [unreadable] [unreadable]..
  20. Role of Galectin-4 in Colitis
    Atsushi Mizoguchi; Fiscal Year: 2008
    ..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
  21. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2008
    ..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. [unreadable] [unreadable]..