Gt(ROSA)26Sor

Summary

Gene Symbol: Gt(ROSA)26Sor
Description: gene trap ROSA 26, Philippe Soriano
Alias: AV258896, Gtrgeo26, Gtrosa26, R26, ROSA26
Species: mouse

Top Publications

  1. pmc Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    S Srinivas
    Department of Genetics and Development, Columbia University, New York, USA
    BMC Dev Biol 1:4. 2001
  2. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
  3. ncbi Generalized lacZ expression with the ROSA26 Cre reporter strain
    P Soriano
    Nat Genet 21:70-1. 1999
  4. ncbi Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein
    Nathan C Shaner
    Nat Biotechnol 22:1567-72. 2004
  5. ncbi Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse
    Shigemi Hayashi
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 244:305-18. 2002
  6. ncbi A global double-fluorescent Cre reporter mouse
    Mandar Deepak Muzumdar
    Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Genesis 45:593-605. 2007
  7. pmc The Lin28/let-7 axis regulates glucose metabolism
    Hao Zhu
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA, USA
    Cell 147:81-94. 2011
  8. pmc A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
    Hiroki Taniguchi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 71:995-1013. 2011
  9. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
  10. ncbi Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    Karl Ludwig Laugwitz
    Institute of Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 433:647-53. 2005

Detail Information

Publications167 found, 100 shown here

  1. pmc Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    S Srinivas
    Department of Genetics and Development, Columbia University, New York, USA
    BMC Dev Biol 1:4. 2001
    ....
  2. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
    ..Using an inducible Cre knock-in allele and the Rosa26-lacZ reporter strain, lineage-tracing experiments were performed in adult mice...
  3. ncbi Generalized lacZ expression with the ROSA26 Cre reporter strain
    P Soriano
    Nat Genet 21:70-1. 1999
  4. ncbi Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein
    Nathan C Shaner
    Nat Biotechnol 22:1567-72. 2004
    ..Three monomers with distinguishable hues from yellow-orange to red-orange have higher quantum efficiencies...
  5. ncbi Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse
    Shigemi Hayashi
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 244:305-18. 2002
    ..This inducible Cre system will be a broadly useful tool to modulate gene activity in mouse embryos, adults, and culture systems where temporal control is an important consideration...
  6. ncbi A global double-fluorescent Cre reporter mouse
    Mandar Deepak Muzumdar
    Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Genesis 45:593-605. 2007
    ..In addition to serving as a global Cre reporter, the mT/mG mouse may also be used as a tool for lineage tracing, transplantation studies, and analysis of cell morphology in vivo...
  7. pmc The Lin28/let-7 axis regulates glucose metabolism
    Hao Zhu
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA, USA
    Cell 147:81-94. 2011
    ..These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism...
  8. pmc A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
    Hiroki Taniguchi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 71:995-1013. 2011
    ..As such, this approach will accelerate the study of GABAergic circuits throughout the mammalian brain...
  9. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
    ..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells...
  10. ncbi Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    Karl Ludwig Laugwitz
    Institute of Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 433:647-53. 2005
    ..The discovery of native cardioblasts represents a genetically based system to identify steps in cardiac cell lineage formation and maturation in development and disease...
  11. ncbi Fate of the mammalian cardiac neural crest
    X Jiang
    Departments of Biological Sciences and Cell and Neurobiology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, IGM 240, Los Angeles, CA 90033, USA
    Development 127:1607-16. 2000
    ....
  12. ncbi Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues
    Konrad Hochedlinger
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 121:465-77. 2005
    ..These data show that certain adult progenitors remain competent to interpret key embryonic signals and support the notion that progenitor cells are a driving force in tumorigenesis...
  13. ncbi Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage
    Jessica A Gorski
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 22:6309-14. 2002
    ..Structures that are located near the basal ganglia (e.g., the amygdala and endopiriform nuclei) are not uniformly derived from Emx1-expressing cells...
  14. ncbi Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
    Fatima el Marjou
    Morphogenesis and intracellular signalling, Institut Curie CNRS, Paris, France
    Genesis 39:186-93. 2004
    ..The villin-Cre and villin-Cre-ERT2 mice provide valuable tools for studies of cell lineage allocation and gene function in the developing and adult intestine...
  15. ncbi Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies
    Hervé Luche
    Institute of Immunology, University Clinics Ulm, Ulm, Germany
    Eur J Immunol 37:43-53. 2007
    ..red fluorescent protein (tdRFP) with advanced spectral and biological properties into the ubiquitously expressed ROSA26 locus of C57BL/6-ES cells, we have generated a novel inbred Cre-reporter mouse with several unique characteristics...
  16. ncbi Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004
    ..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient...
  17. pmc Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons
    Goichi Miyoshi
    Smilow Neuroscience Program and the Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 30:1582-94. 2010
    ..Thus, in conjunction with previous studies, we have now determined the spatial and temporal origins of the vast majority of cortical interneuron subtypes...
  18. ncbi Transgenic mice with hematopoietic and lymphoid specific expression of Cre
    Jasper de Boer
    Department of Molecular Immunology, National Institute for Medical Research, The Ridgeway, London, GB
    Eur J Immunol 33:314-25. 2003
    ..Both of these Cre-transgenic lines will be useful in generating tissue-specific gene deletions within all the cells of hematopoietic or lymphoid tissues...
  19. pmc Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion
    Peng Li
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Science 329:85-9. 2010
    ..Therefore, ITNKs may represent a new cell source for cell-based therapies...
  20. doi The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
    Rui Benedito
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    Cell 137:1124-35. 2009
    ....
  21. pmc Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain
    Barton Wicksteed
    Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Chicago, Chicago, llinois, USA
    Diabetes 59:3090-8. 2010
    ..The objective of this study was to examine whether mouse transgenic Cre lines, used to mediate β-cell- or pancreas-specific recombination, also drive Cre expression in the brain...
  22. ncbi Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
    Blair B Madison
    Department of Cell and Developmental Biology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0616, USA
    J Biol Chem 277:33275-83. 2002
    ....
  23. pmc Leptin targets in the mouse brain
    Michael M Scott
    Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Comp Neurol 514:518-32. 2009
    ..Thus, we provide data supporting the use of the LepRb-IRES-Cre line for the assessment of the anatomic and functional characteristics of neurons expressing leptin receptor...
  24. ncbi Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo
    Y Y Kisanuki
    Department of Molecular Genetics, Howard Hughes Medical Institute, Dallas, Texas, 75390 9050, USA
    Dev Biol 230:230-42. 2001
    ..Tie2-Cre transgenic mice are a new genetic tool for the analyses of endothelial cell-lineage and endothelial cell-specific gene targeting...
  25. ncbi The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    Yoshiya Kawaguchi
    Vanderbilt Developmental Biology Program, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232 2175, USA
    Nat Genet 32:128-34. 2002
    ..These experiments provide evidence that Ptf1a expression is specifically connected to the acquisition of pancreatic fate by undifferentiated foregut endoderm...
  26. pmc Aberrant T cell differentiation in the absence of Dicer
    Stefan A Muljo
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 202:261-9. 2005
    ..Independent of their proliferation defect, Dicer-deficient helper T cells preferentially expressed interferon-gamma, the hallmark effector cytokine of the Th1 lineage...
  27. ncbi A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
    Thorsten Buch
    Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    Nat Methods 2:419-26. 2005
    ..Notably, we show that the developing DT-specific antibody response is weak and not neutralizing, and thus does not impede the efficacy of DT. Our results validate the use of iDTR mice as a tool for cell ablation in vivo...
  28. pmc Testing gene function early in the B cell lineage in mb1-cre mice
    E Hobeika
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 103:13789-94. 2006
    ..The availability of a mouse line with efficient cre-mediated recombination at an early developmental stage in the B lineage provides an opportunity to study the role of various genes specifically in B cell development and function...
  29. doi The cell and molecular basis of mechanical, cold, and inflammatory pain
    Bjarke Abrahamsen
    Molecular Nociception Group, University College London UCL, Gower Street, London, WC1E 6BT, UK
    Science 321:702-5. 2008
    ..These data demonstrate that Na(v)1.8-expressing neurons are essential for mechanical, cold, and inflammatory pain but not for neuropathic pain or heat sensing...
  30. pmc Basal cells as stem cells of the mouse trachea and human airway epithelium
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:12771-5. 2009
    ..Like those from the mouse trachea, human airway basal cells both self-renew and generate luminal daughters in the sphere-forming assay...
  31. ncbi Cell tracing shows the contribution of the yolk sac to adult haematopoiesis
    Igor M Samokhvalov
    Laboratory for Stem Cell Biology, Center for Developmental Biology, RIKEN Kobe, Kobe 650 0047, Japan
    Nature 446:1056-61. 2007
    ..We observed virtually no contribution of the labelled cells towards the yolk sac vasculature, indicating early segregation of endothelial and haematopoietic lineages...
  32. pmc Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen
    Michele L Caton
    Department of Microbiology, Columbia University Medical Center, New York, NY 10032, USA
    J Exp Med 204:1653-64. 2007
    ..Thus, canonical Notch-RBP-J signaling controls the maintenance of CD8(-) DCs in the splenic MZ, revealing an unexpected role of the Notch pathway in the innate immune system...
  33. pmc Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 454:109-13. 2008
    ..These results identify Wt1(+) epicardial cells as previously unrecognized cardiomyocyte progenitors, and lay the foundation for future efforts to harness the cardiogenic potential of these progenitors for cardiac regeneration and repair...
  34. pmc Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma
    Etienne Meylan
    Koch Institute for Integrative Cancer Research, and Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 462:104-7. 2009
    ..These findings also provide support for the development of NF-kappaB inhibitory drugs as targeted therapies for the treatment of patients with defined mutations in Kras and p53...
  35. pmc Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance
    Gina M Leinninger
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 14:313-23. 2011
    ..Thus, LHA LepRb(Nts) neurons mediate physiologic leptin action on OX neurons and the mesolimbic DA system, and contribute importantly to the control of energy balance...
  36. pmc Corneal avascularity is due to soluble VEGF receptor-1
    Balamurali K Ambati
    Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
    Nature 443:993-7. 2006
    ....
  37. ncbi TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    Neil A Bhowmick
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Science 303:848-51. 2004
    ..Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues...
  38. ncbi Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
    Jean Livet
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 450:56-62. 2007
    ..The ability of the Brainbow system to label uniquely many individual cells within a population may facilitate the analysis of neuronal circuitry on a large scale...
  39. doi Multiple layers of B cell memory with different effector functions
    Ismail Dogan
    Institut National de la Santé et de la Recherche Médicale U783 Développement du système immunitaire, Universite Paris Descartes, Faculte de Medecine, Site Necker Enfants Malades, Paris, France
    Nat Immunol 10:1292-9. 2009
    ..This model, in which B cell memory appears in several layers with different functions, reconciles previous conflicting propositions...
  40. doi Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth
    Myriam Solar
    Genomic Programming of Beta Cells Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    Dev Cell 17:849-60. 2009
    ..Thus, once the ductal epithelium differentiates it has a restricted plasticity, even under regenerative settings...
  41. pmc IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 207:273-80. 2010
    ..1(-)Rorc(+) cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets...
  42. pmc Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog
    Eric Dessaud
    Developmental Neurobiology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Biol 8:e1000382. 2010
    ..This suggests an alternative to conventional models of morphogen action that rely solely on the level of signalling...
  43. pmc Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, and Lung Biology Center, UCSF, San Francisco, California 94143, USA
    J Clin Invest 121:2855-62. 2011
    ....
  44. pmc PI3K integrates the action of insulin and leptin on hypothalamic neurons
    Allison Wanting Xu
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 115:951-8. 2005
    ..These results suggest a new view of hypothalamic circuitry, in which the effects of leptin and insulin are integrated by anorexigenic but not by orexigenic neurons...
  45. ncbi Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
    Anna L Means
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Development 132:3767-76. 2005
    ....
  46. ncbi Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors
    Rob Machold
    Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Neuron 48:17-24. 2005
    ..Thus, we demonstrate that the cerebellar rhombic lip gives rise to multiple cell types within rhombomere 1...
  47. ncbi Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues
    Dorothe Hameyer
    Institute of Toxicology Mouse Genetics, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Physiol Genomics 31:32-41. 2007
    ..To compare ligand-dependent Cre recombinases, different Cre estrogen receptor fusions were introduced into the ROSA26 locus of embryonic stem (ES) cells and assayed for genotoxicity and recombination efficiency...
  48. doi Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria
    Nikolai N Belyaev
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London, UK
    Nat Immunol 11:477-85. 2010
    ..Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection...
  49. pmc FGF10 controls the patterning of the tracheal cartilage rings via Shh
    Frederic G Sala
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Development 138:273-82. 2011
    ..We propose that disturbed balances of Fgf10 and Shh may explain a subset of human tracheomalacia without tracheo-esophageal fistula or tracheal atresia...
  50. pmc Context-specific α- to-β-cell reprogramming by forced Pdx1 expression
    Yu Ping Yang
    Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 25:1680-5. 2011
    ..Our findings reveal that Pdx1 can work single-handedly as a potent context-dependent autonomous reprogramming agent, and suggest a postnatal differentiation evaluation stage involved in normal endocrine maturation...
  51. ncbi Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice
    K U Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Transgenic Res 10:545-53. 2001
    ..We have now characterized in depth the expression of the MMTV-Cre transgene using the ROSA26-lox-Stop-lox-LacZ reporter strain to determine the temporal and spatial activation of Cre on the level of single ..
  52. ncbi Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types
    Susan E Schonhoff
    Division of Gastroenterology, GRASP Digestive Disease Center, Tufts New England Medical Center, Boston, MA 02111, USA
    Dev Biol 270:443-54. 2004
    ..Thus, ngn3 expression occurs in mixed populations of immature cells that are not irreversibly committed to endocrine differentiation...
  53. pmc Dynamic contribution of nestin-expressing stem cells to adult neurogenesis
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 27:12623-9. 2007
    ....
  54. doi A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
  55. pmc Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells
    Yunfu Sun
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Dev Biol 304:286-96. 2007
    ..Our studies suggest a role for Isl1 in these distinct domains of expression within the heart...
  56. ncbi Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis
    Noah F Shroyer
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 132:2478-88. 2007
    ..We hypothesized that Math1 is important in cell fate commitment, and therefore mediates proliferative homeostasis and the adaptive response following intestinal resection in the adult intestine...
  57. pmc Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction
    Gusztav Belteki
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Nucleic Acids Res 33:e51. 2005
    ..To ensure reliable rtTA expression in a broad range of cell types, we have targeted the rtTA transgene into the ROSA26 locus...
  58. doi Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
    Hugo J Snippert
    Hubrecht Institute KNAW Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
    Science 327:1385-9. 2010
    ..Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell...
  59. pmc Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells
    Tudor C Badea
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 61:852-64. 2009
    ..These findings reveal distinct roles for Brn3a and Brn3b in programming RGC diversity, and they illustrate the broad utility of germline methods for genetically manipulating and visualizing individual identified mammalian neurons...
  60. pmc Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver
    Christoph H Osterreicher
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:308-13. 2011
    ..These findings suggest that FSP1 is a marker of a specific subset of inflammatory macrophages in liver injury, fibrosis, and cancer...
  61. pmc A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway
    Dónal O'Carroll
    The Laboratory for Lymphocyte Signaling, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 21:1999-2004. 2007
    ..Collectively, our data identify Ago2 as a highly specialized member of the Argonaute family with an essential nonredundant Slicer-independent function within the mammalian miRNA pathway...
  62. ncbi Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis
    Harikrishna Tanjore
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Dev Dyn 237:75-82. 2008
    ..These results indicate that beta1 integrin expression on vascular endothelial cells is crucial for embryonic angiogenesis but dispensable for vasculogenesis...
  63. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
    ..Therefore, the decision of antigen-stimulated cells to differentiate into either T(H)17 or T(reg) cells depends on the cytokine-regulated balance of RORgammat and Foxp3...
  64. pmc Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes
    Thomas S Jacques
    Neural Development Unit, UCL Institute of Child Health and Department of Histopathology, Great Ormond Street Hospital, London, UK
    EMBO J 29:222-35. 2010
    ..Our study underlines an important role of stem cells and the relevance of initial genetic mutations in the pathogenesis and phenotype of brain tumours...
  65. doi Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantation
    S H Huang
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Diabetologia 53:2389-400. 2010
    ..We investigated whether transgenic expression of Ho-1 (also known as Hmox1) in pancreatic beta cells would protect NOD mice from autoimmune damage and prolong graft survival following islet transplantation...
  66. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
    ..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription...
  67. pmc NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration
    Shin H Kang
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA
    Neuron 68:668-81. 2010
    ..These results indicate that NG2+ cells in the normal CNS are oligodendrocyte precursors with restricted lineage potential and that cell loss and gliosis are not sufficient to alter the lineage potential of these progenitors...
  68. pmc Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production
    Michal Safran
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:105-10. 2006
    ....
  69. pmc Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    Debra F Higgins
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:3810-20. 2007
    ....
  70. ncbi NG2 cells generate both oligodendrocytes and gray matter astrocytes
    Xiaoqin Zhu
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269 3156, USA
    Development 135:145-57. 2008
    ..These observations suggest that NG2+ cells are precursors of oligodendrocytes and some protoplasmic astrocytes in gray matter...
  71. pmc Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate
    Vishakha S Mangale
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Science 319:304-9. 2008
    ..In addition to providing functional evidence for Lhx2 selector activity, these findings show that the cortical hem is a hippocampal organizer...
  72. pmc Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
    Changchun Xiao
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 9:405-14. 2008
    ..This mechanism probably contributed to the lymphoproliferative disease and autoimmunity of miR-17-92-transgenic mice and contributes to lymphoma development in patients with amplifications of the miR-17-92 coding region...
  73. pmc Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice
    Libing Zhou
    Developmental Neurobiology, Universite Catholique de Louvain, 1200 Bruxelles, Belgique
    Science 320:946-9. 2008
    ..These observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals...
  74. pmc Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
    Akari Inada
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:19915-9. 2008
    ..expressing human carbonic anhydrase II (CAII) promoter: Cre recombinase (Cre) or inducible CreER(TM) to cross with ROSA26 loxP-Stop-loxP LacZ reporter mice...
  75. pmc Inactivation of p53 and Pten promotes invasive bladder cancer
    Anna M Puzio-Kuter
    Department of Urology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Genes Dev 23:675-80. 2009
    ..Our integrated analyses of mouse and human bladder cancer provide a rationale for investigating mTOR inhibition for treatment of patients with invasive disease...
  76. pmc Characterization of Nkx6-2-derived neocortical interneuron lineages
    Vitor H Sousa
    Neuroscience Program, Smilow Research Center, New York University, New York, NY 10016, USA
    Cereb Cortex 19:i1-10. 2009
    ....
  77. pmc Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells
    Ying V Zhang
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Cell Stem Cell 5:267-78. 2009
    ..We propose that large clusters of tissue stem cells behave as populations whose maintenance involves unidirectional daughter-cell-fate decisions...
  78. doi The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia
    Ulf Klein
    Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Cancer Cell 17:28-40. 2010
    ..miR-15a/16-1-deletion accelerates the proliferation of both human and mouse B cells by modulating the expression of genes controlling cell-cycle progression. These results define the role of 13q14 deletions in the pathogenesis of CLL...
  79. pmc Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism
    Ann C Zovein
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 18:39-51. 2010
    ..Combined, our findings demonstrate that beta1 integrin functions upstream of Par3 as part of a molecular cascade required for endothelial cell polarity and lumen formation...
  80. pmc The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages
    Ivan Dzhagalov
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 109:1620-6. 2007
    ..These data suggest that Mcl-1 plays a nonredundant role in promoting the survival of neutrophils but not macrophages...
  81. pmc Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    Jean Paul De La O
    Department of Human Genetics, University of Utah, 15 North 2030 East, Room 2100, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 105:18907-12. 2008
    ..At the cellular level, Notch/Kras coactivation promotes rapid reprogramming of acinar cells to a duct-like phenotype, providing an explanation for how a characteristically ductal tumor can arise from nonductal acinar cells...
  82. ncbi A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA
    E C Lee
    Mouse Cancer Genetics Program, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Genomics 73:56-65. 2001
    ....
  83. ncbi Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex
    D Graus-Porta
    Friedrich Miescher Institute, Maulbeerstr 66, 4058, Basel, Switzerland
    Neuron 31:367-79. 2001
    ..The phenotype of the beta1-deficient mice resembles pathological changes observed in human cortical dysplasias, suggesting that defective integrin-mediated signal transduction contributes to the development of some of these diseases...
  84. pmc A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype
    Andrew J Syder
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:4471-6. 2004
    ....
  85. ncbi Targeted insertion of the Cre-recombinase gene at the phenylethanolamine n-methyltransferase locus: a new model for studying the developmental distribution of adrenergic cells
    Steven N Ebert
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20057, USA
    Dev Dyn 231:849-58. 2004
    ..epinephrine biosynthetic enzyme phenylethanolamine n-methyltransferase (Pnmt) and crossed these Pnmt-Cre mice with ROSA26 reporter (R26R) mice to activate LacZ (encoding beta-galactosidase) expression in cells that were selectively ..
  86. pmc An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo
    Junhao Mao
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Nucleic Acids Res 33:e155. 2005
    ..in a novel embryonic stem (ES) cell line enables rapid identification of targeting to the ubiquitously expressed Rosa26 locus...
  87. pmc SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
    ..These findings will be of major significance for the development of in vitro protocols for cell replacement therapies...
  88. ncbi Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal
    Francesca Balordi
    Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:14248-59. 2007
    ..These results demonstrate that ongoing hedgehog signaling is required to maintain adult neural stem cells and that their ability to self-renew is limited...
  89. doi Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
    Ilaria Malanchi
    Ecole Polytechnique Fédérale de Lausanne ISREC Swiss Institute for Experimental Cancer Research and National Center of Competence in Research Molecular Oncology, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 452:650-3. 2008
    ..Because Wnt/beta-catenin signalling is not essential for normal epidermal homeostasis, such a mechanistic difference may thus be targeted to eliminate CSCs and consequently eradicate squamous cell carcinomas...
  90. pmc The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages
    Ivan Dzhagalov
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 181:521-8. 2008
    ..Furthermore, we demonstrate that Mcl-1 functions together with Bcl-xL to promote double-positive thymocyte survival. Thus, Mcl-1 is a critical anti-apoptotic factor for the survival of T cells at multiple stages in vivo...
  91. pmc An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice
    Milena Traykova-Brauch
    Department of Cellular and Molecular Pathology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Med 14:979-84. 2008
    ..These experiments establish Pax8-rtTA mice as a powerful tool for modeling renal diseases in transgenic mice...
  92. pmc Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus
    Tianyu Zhao
    Department of Genes and Behavior, Brain Development Group, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Eur J Neurosci 28:1941-55. 2008
    ..The expanded neuroepithelium generates abundant neurons for the medial hypothalamus at the tuberal level. Finally, we have uncovered novel diencephalon-to-telencephalon migrations into septum, piriform cortex and amygdala...
  93. pmc Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion
    Gwanghee Lee
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:4701-6. 2009
    ..These findings have implications for the development of novel, less cytotoxic cancer chemotherapeutic drugs that specifically target the cell cycle...
  94. pmc Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus
    Li Chen
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Development 136:1317-26. 2009
    ..We propose that, within the developing thalamus, the dynamic and differential expression of Gbx2 may be involved in the specific segregation of thalamic neurons, leading to partition of the thalamus into different nuclei...
  95. doi Lineage analysis of quiescent regenerative stem cells in the adult brain by genetic labelling reveals spatially restricted neurogenic niches in the olfactory bulb
    Claudio Giachino
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Eur J Neurosci 30:9-24. 2009
    ..In summary, using conditional lineage tracing we have identified neonatal cells that are the source of neurogenic and regenerative neural stem cells in the adult SVZ and occupy a novel neurogenic niche in the OB...
  96. pmc Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice
    Eric Camerer
    Cardiovascular Research Institute, UCSF, San Francisco, California 94158 2517, USA
    J Clin Invest 119:1871-9. 2009
    ..Our results suggest that the blood communicates with blood vessels via plasma S1P to maintain vascular integrity and regulate vascular leak. This pathway prevents lethal responses to leak-inducing mediators in mouse models...
  97. pmc Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice
    Cindy L Yee
    Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, Genetics and Development, San Francisco, California 94158 2611, USA
    J Comp Neurol 517:37-50. 2009
    ..These results have implications for the genetic control of arcuate development and function and for the utility of the Nkx2.1-Cre and Dlx5/6i-Cre mouse lines to alter gene expression in the developing arcuate...
  98. pmc Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model
    David J Mulholland
    Departments of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, California 90095 1735, USA
    Cancer Res 69:8555-62. 2009
    ..Therefore, the LSC subpopulation is capable of initiating a cancerous phenotype that recapitulates the pathology seen in the primary lesions of the Pten mutant prostate model...
  99. pmc Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation
    Jason Michaud
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 184:1475-83. 2010
    ..Our results suggest that S1P serves as a negative regulator of macrophage recruitment by inhibiting migration in these cells and identify an additional facet to the regulation of leukocyte trafficking by S1P...
  100. pmc A primary cilia-dependent etiology for midline facial disorders
    Samantha A Brugmann
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
    Hum Mol Genet 19:1577-92. 2010
    ..These data also raise the possibility that genes encoding ciliary proteins are candidates for human conditions of hypertelorism and FNDs...
  101. pmc Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development
    Arjan van der Flier
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Development 137:2439-49. 2010
    ..These integrins on other cells, and/or other integrins on endothelial cells, might contribute to fibronectin assembly and vascular development...

Research Grants65

  1. Somatomedin: Autologous Regulator of Bone Formation
    Ernesto Canalis; Fiscal Year: 2008
    ..These investigations should clarify the role of CHOP in bone cell differentiation and function. [unreadable] [unreadable]..
  2. Muscle protein synthesis and gene expression in myostatin-deficient mice
    Stephen L Welle; Fiscal Year: 2010
    ..Knowledge of the physiological and molecular effects of reducing myostatin activity in mature muscle will reveal potential benefits and limitations of anti-myostatin therapy. ..
  3. CHANGES IN GENE EXPRESSION IN SENESCENT MUSCLE
    Stephen Welle; Fiscal Year: 2003
    ..abstract_text> ..
  4. Conditional Deletion of Dnaic1 as a Model of Primary Ciliary Dyskinesia
    LAWRENCE OSTROWSKI; Fiscal Year: 2007
    ..If successful, this model will also provide a novel system to investigate other questions concerning pulmonary health and disease. [unreadable] [unreadable] [unreadable]..
  5. Calcium channels at ribbon synapses in the retina
    CATHERINE MORGANS; Fiscal Year: 2008
    ..The results of these experiments will provide insight into the composition and functional organization of retinal ribbon synapses and into the perturbation of retinal function associated with CSNB2. ..
  6. GENETIC AND BEHAVIORAL DISSECTION OF INHIBITORY CONTROL
    Xiaoxi Zhuang; Fiscal Year: 2008
    ..Aim 3 is to test directly the hypothesis that impaired D2 receptor function underlies impaired inhibitory control using mice that lack or have reduced postsynaptic D2 receptors. ..
  7. Epigenetic Mechanisms in Motor Habits Stability
    Xiaoxi Zhuang; Fiscal Year: 2007
    ..These studies will point to potential epigenetic interventions in the future that may be able to treat drug addition by reversing motor habits. [unreadable] [unreadable] [unreadable]..
  8. Skeletal Biology and Medicine Conference
    Mone Zaidi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  9. Phenotypic screen in mouse embryonic for TGF-beta signaling mutations
    JAY VIVIAN; Fiscal Year: 2007
    ..Cell-based mutation screening strategies as developed in this proposal can be applied to any active biochemical pathway in mouse ES cells, to generate mouse lines for analysis in vivo. [unreadable] [unreadable] [unreadable]..
  10. The Role of NFATc1 and Calcineurin in Bone Remodeling
    Mone Zaidi; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  11. Redox-mediated NF-kappaB activation by LPS and IL-1
    JOHN ENGELHARDT; Fiscal Year: 2008
    ..Findings from these studies may lead to alternative therapeutic approaches targeting the liver by which to abrogate the detrimental effects of systemic cytokine production during sepsis. ..
  12. Central Serotonergic Pathways Regulating Energy Balance
    LORA HEISLER; Fiscal Year: 2007
    ....
  13. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2007
    ..abstract_text> ..
  14. 2006 Cancer Model Mechanisms
    William Kaelin; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  15. ROLE OF THE LCR IN HUMAN BETA-GLOBIN GENE REGULATION
    KENNETH PETERSON; Fiscal Year: 2001
    ..Specific Aim 3 will test the role of the LCR sequences in LCR complex formation and globin gene regulation using transgenic mice containing mutant beta-globin loci by applying FRET. ..
  16. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  17. MECHANISMS OF RAAV TRANSDUCTION IN THE AIRWAY
    JOHN ENGELHARDT; Fiscal Year: 2008
    ..Further elucidation of rAAV transduction biology in the airway will aid in the development of clinically applicable methods for increasing the efficacy of rAAV gene transfer in vivo. ..
  18. Molecular Studies of Brain Malformations
    Huaiyu Hu; Fiscal Year: 2007
    ....
  19. TGF-beta Signaling in Chondrocyte Differentiation
    Rosa Serra; Fiscal Year: 2008
    ..The results of these studies will enhance our understanding of molecular events involved in development and maintenance of the skeletal system. [unreadable] [unreadable]..
  20. Mechanisms of In Vivo Cell Fusion
    Andrew Duncan; Fiscal Year: 2008
    ..Aim 2: To determine relevant properties of fusion-derived hepatocytes. Aim 3: To enhance in vivo cell fusion by expression of fusogenic viral envelope proteins. [unreadable] [unreadable] [unreadable]..
  21. Excitatory Activity Control of Adult Neurogenesis
    Karl Deisseroth; Fiscal Year: 2008
    ..program that can be transitioned to a tenure-track position in a psychiatry department, where I look forward to continuing with 75-80% research and 20-25% patient care, and opportunities to teach and mentor others ..
  22. Role of ALK3 in atrioventricular valve development
    Vinciane Gaussin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  23. Transactivation of Fetal Hemoglobin
    KENNETH PETERSON; Fiscal Year: 2007
    ..This proposal will generate unique tools and new strategies to understand mechanisms of ?-globin gene regulation for treatment of SCD. ..
  24. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  25. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA P MISRA; Fiscal Year: 2010
    ....
  26. Molecular Imaging of Novel Cardiomyocyte Stem Cells
    STEVEN EBERT; Fiscal Year: 2009
    ..Aim 2: In vivo magnetic resonance imaging (MRI) of transplanted cardiomyocyte stem (Pnmt+) cells. Aim 3: In vivo bioluminescence imaging (BLI) of transplanted cardiomyocyte stem (Pnmt+) cells. (End of Abstract) ..
  27. Chromatin-based cellular memory in neural stem cells
    Daniel Lim; Fiscal Year: 2009
    ..Furthermore, our studies may lead to discoveries of how derangements in chromatin remodeling can lead to the development of brain tumors. ..
  28. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  29. HNF6 Function in the Pancreatic Endocrine Lineage
    Maureen A Gannon; Fiscal Year: 2010
    ..e. is HNF6 needed only at early stages of endocrine specification, or is it required continuously during embryogenesis for terminal differentiation and acquisition of mature function. ..
  30. ROLE OF MYOSTATIN IN CACHEXIA
    Se Jin Lee; Fiscal Year: 2005
    ..abstract_text> ..
  31. DAB2 AND RAS REGULATION
    Xiangxi Xu; Fiscal Year: 2001
    ..These mechanistic studies of Dab2 will enhance our understanding of its role in cell growth regulation and the possible involvement in breast and ovary tumorigenicity. ..
  32. GENDER AND RISK OF DRUG INDUCED CARDIAC ARRHYTHMIAS
    STEVEN EBERT; Fiscal Year: 2001
    ....
  33. TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAIL
    DAVID BASILE; Fiscal Year: 2002
    ..abstract_text> ..
  34. SMAD MEDIATED SIGNALING DURING LUNG MORPHOGENESIS
    Wei Shi; Fiscal Year: 2002
    ..The results of this project will provide new rationales for novel therapeutic strategies to modulate TGF-beta signaling during lung development, injury, repair, and disease. ..
  35. IDENTIFICATION OF BIOCHEMICAL ABNORMALITIES IN PCD CILIA
    LAWRENCE OSTROWSKI; Fiscal Year: 2002
    ..Further studies of the role of these proteins in the assembly and function of cilia may also result in improved treatment for other air way diseases. ..
  36. TG737 SIGNALING PATHWAY AND POLYCYSTIC KIDNEY
    Bradley Yoder; Fiscal Year: 2003
    ..Overall, results generated from this proposal will give important insight into the biological function of Tg737 and how disruption of the Tg737/polycystin-1 signaling pathway results in the formation of renal cyst. ..
  37. DEVELOPMENTAL MECHANISMS OF HOXA5 SPATIAL REGULATION
    Lucie Jeannotte; Fiscal Year: 2003
    ..Completion of these aims will provide critical information required for elucidating the pathway controlling Hoxa5 expression, information useful to develop a detailed understanding of regional patterning during development. ..
  38. NEURONAL MIGRATION IN THE DEVELOPING BRAIN
    Huaiyu Hu; Fiscal Year: 2003
    ....
  39. CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATION
    Mone Zaidi; Fiscal Year: 2003
    ..Taken together, the studies should provide mechanistic insights into the role of the NAD+/CD38/cADPr/Ca2+ system in osteoclast control. ..
  40. The Role of Sonic Hedgehog in telencephalic patterning
    Robert Machold; Fiscal Year: 2004
    ..This work will hopefully lead to a deeper understanding of regional specification in the developing forebrain. ..
  41. Locus-linked Regulatory Motifs of Globin Gene Switching
    KENNETH PETERSON; Fiscal Year: 2004
    ....
  42. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  43. CNS Disease and Autoimmunity of Glutamate Receptors
    Scott Rogers; Fiscal Year: 2005
    ..abstract_text> ..
  44. SRF/MYOCD: new targets in Alzheimer's neurovasculature
    JOSEPH MIANO; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  45. A Ciliated Cell-Specific Promoter for Gene Therapy of CF
    LAWRENCE OSTROWSKI; Fiscal Year: 2005
    ..Specific Aim 3: To demonstrate correction of the CF phenotype in both in vitro and in vivo models by targeted expression of the normal CFTR gene in ciliated cells. ..
  46. SACRAL CREST CELLS AND ENTERIC NEURODEVELOPMENT
    Raj Kapur; Fiscal Year: 2005
    ..The results of this study will further our understanding of normal enteric neurodevelopment and congenital disorders of intestinal motility. ..
  47. THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENT
    RAVINDRA MISRA; Fiscal Year: 2005
    ..These studies will both elucidate the mechanisms by which SRF functions in heart and will establish powerful new methodologies for studying heart formation and function. ..
  48. The role of HNF4 in gastrointestinal development
    Michele Battle; Fiscal Year: 2006
    ..By understanding how this transcription factor functions in the gut, greater insight into the fundamental molecular processes underlying gut development wilt be gained. ..
  49. TGFb in stromal epithelial interactions in mammary gland
    Rosa Serra; Fiscal Year: 2005
    ..The proposed experiments will improve our understanding of stromal-epithelial interactions in the mammary gland. ..
  50. Kim-1 in Renal Epithelial Cell Motility and Adhesion
    BENJAMIN HUMPHREYS; Fiscal Year: 2005
    ..The proposed studies will have great relevance in understanding the molecular mechanisms of renal regeneration and renal cell cancer invasion and metastasis. ..
  51. Analysis of a Retinoid-Induced Tumor Suppressor in SMC
    JOSEPH MIANO; Fiscal Year: 2006
    ..Such information has enormous potential for understanding and treating human vascular Idisease and other pathological disorders, including cancer where retinoids have been in clinical use for years. ..
  52. ROLE OF THE PTEN PATHWAY IN MELANOMA
    Marcus Bosenberg; Fiscal Year: 2005
    ..He has also completed Ph.D. training in cell biology. The proposed research will be carried out in the laboratory of Dr. Ronald DePinho at the Dana-Farber Cancer Institute, an affiliate of the Harvard Medical School. ..
  53. NEURAL AND MECHANICAL REGULATION OF SLOW MYOSIN
    Karyn Esser; Fiscal Year: 2004
    ....
  54. Skeletal Development and Remodeling in Health, Disease and Aging
    Mone Zaidi; Fiscal Year: 2005
    ..A local forum, which will provide the non-scientific public an informal opportunity to learn about the latest research and therapies emerging in the field, is also planned. ..
  55. The Role of Cartilage Link Protein 1 (Crtl1) in Heart Development
    ARNO WESSELS; Fiscal Year: 2010
    ..Understanding the role of Crtl1, and Crtl1-associated mechanisms, in heart development may further our knowledge of the etiology of a variety of these malformations including the mechanisms that lead to muscular septal defects. ..
  56. The role of nyctalopin in the mammalian retina
    CATHERINE MORGANS; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  57. Adipogenesis, Obesity and Inflammation
    Philipp Scherer; Fiscal Year: 2005
    ..Some sessions will be held jointly with the "Diabetes Mellitus and the control of Cellular Energy Metabolism" meeting that will effectively complement the obesity meeting. ..
  58. Locus-linked Regulatory Motifs of Globin Gene Switching
    KENNETH PETERSON; Fiscal Year: 2008
    ..abstract_text> ..
  59. Foxm 1b endocrine pancreas growth and regeneration
    Maureen Gannon; Fiscal Year: 2009
    ..A thorough understanding of Foxml regulation of 3 cell mass may lead to strategies for maintaining 3 cell mass and enhancing 3 cell proliferation in diabetics. ..
  60. TGF-beta Signaling in Mesenchymal Chondroprogenitors
    Anna Spagnoli; Fiscal Year: 2007
    ..Understanding the role of TGF-beta in MCC biology will provide a framework for therapeutic manipulations to optimize the use of MCC in cartilage diseases. ..
  61. New Insights into Animals Models of Diabetes
    Edward Leiter; Fiscal Year: 2003
    ..The meeting is planned for 200 participants. Because of limited seating capacity in The Jackson Laboratory's auditorium, the meeting venue will be the Bar Harbor Regency Hotel, where participants will be housed and fed. ..
  62. The role of EGFR signaling in progression of Kras-induced pacreatic tumors
    Anna Means; Fiscal Year: 2007
    ..The studies proposed here investigate EGFR signaling as a potential biomarker and/or therapeutic target, by studying its effects on tumorigenesis in a mouse model of pancreatic cancer. [unreadable] [unreadable] [unreadable]..
  63. TGFbeta/Bmp Signaling during Mammalian Lens Development
    Yasuhide Furuta; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  64. Function of GATA-6 in Vascular Smooth Muscle
    John Lepore; Fiscal Year: 2005
    ..End of Abstract) ..