Grin1

Summary

Gene Symbol: Grin1
Description: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Alias: GluN1, GluRdelta1, GluRzeta1, M100174, NMD-R1, NMDAR1, NR1, Nmdar, Rgsc174, glutamate receptor ionotropic, NMDA 1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta-1
Species: mouse

Top Publications

  1. pmc Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex
    T Iwasato
    Laboratory for Behavioral Genetics, Brain Science Institute, RIKEN, Saitama, Japan
    Nature 406:726-31. 2000
  2. ncbi Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
    C Rampon
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, New Jersey 08540 1014, USA
    Nat Neurosci 3:238-44. 2000
  3. pmc Cardiac specific deletion of N-methyl-d-aspartate receptor 1 ameliorates mtMMP-9 mediated autophagy/mitophagy in hyperhomocysteinemia
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    J Recept Signal Transduct Res 30:78-87. 2010
  4. ncbi Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice
    Y Li
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts
    Cell 76:427-37. 1994
  5. ncbi NMDA receptor-dependent refinement of somatotopic maps
    T Iwasato
    Howard Hughes Medical Institute, Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 19:1201-10. 1997
  6. pmc Exuberant thalamocortical axon arborization in cortex-specific NMDAR1 knockout mice
    Li Jen Lee
    Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Comp Neurol 485:280-92. 2005
  7. pmc Channel-mediated astrocytic glutamate release via Bestrophin-1 targets synaptic NMDARs
    Kyung Seok Han
    Center for Neural Science and WCI Center for Functional Connectomics, Korea Institute of Science and Technology KIST, Seoul, Korea
    Mol Brain 6:4. 2013
  8. pmc Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice
    H W Kim
    Department of Physiology, College of Medicine and Research Institute for Medical Sciences, Chungnam National University, Daejeon, South Korea
    Br J Pharmacol 154:1125-34. 2008
  9. pmc Functional disturbances in the striatum by region-specific ablation of NMDA receptors
    Nobuhisa Ohtsuka
    Center for Systems Neurobiology, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 105:12961-6. 2008
  10. pmc Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit
    I Ito
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    J Physiol 500:401-8. 1997

Research Grants

Detail Information

Publications128 found, 100 shown here

  1. pmc Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex
    T Iwasato
    Laboratory for Behavioral Genetics, Brain Science Institute, RIKEN, Saitama, Japan
    Nature 406:726-31. 2000
    ..We have generated mice in which deletion of the NMDAR1 (NR1) gene is restricted to excitatory cortical neurons, and here we show that sensory periphery-related patterns ..
  2. ncbi Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
    C Rampon
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, New Jersey 08540 1014, USA
    Nat Neurosci 3:238-44. 2000
    ..Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes...
  3. pmc Cardiac specific deletion of N-methyl-d-aspartate receptor 1 ameliorates mtMMP-9 mediated autophagy/mitophagy in hyperhomocysteinemia
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    J Recept Signal Transduct Res 30:78-87. 2010
    ..8 g of DL-Hcy/L in the drinking water for 6 weeks), NMDA-R1 KO + Hcy, and NR1(fl/fl)/Cre (NR1(fl/fl)) genetic control mice...
  4. ncbi Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice
    Y Li
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts
    Cell 76:427-37. 1994
    ..We applied the gene targeting to the NMDAR1 gene and created a mutant mouse that lacks functional NMDA receptors...
  5. ncbi NMDA receptor-dependent refinement of somatotopic maps
    T Iwasato
    Howard Hughes Medical Institute, Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 19:1201-10. 1997
    ..We demonstrate that ectopic expression of a transgene of an NMDAR1 splice variant rescues neonatally fatal NMDAR1 knockout (KO) mice, although the average life span varies depending ..
  6. pmc Exuberant thalamocortical axon arborization in cortex-specific NMDAR1 knockout mice
    Li Jen Lee
    Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Comp Neurol 485:280-92. 2005
    Development of whisker-specific neural patterns in the rodent somatosensory system requires NMDA receptor (NMDAR)-mediated activity...
  7. pmc Channel-mediated astrocytic glutamate release via Bestrophin-1 targets synaptic NMDARs
    Kyung Seok Han
    Center for Neural Science and WCI Center for Functional Connectomics, Korea Institute of Science and Technology KIST, Seoul, Korea
    Mol Brain 6:4. 2013
    ..The target of Best1-mediated astrocytic glutamate has been shown to be the neuronal NMDA receptors (NMDAR). However, whether it targets synaptically or extra-synaptically localized NMDAR is not known.
  8. pmc Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice
    H W Kim
    Department of Physiology, College of Medicine and Research Institute for Medical Sciences, Chungnam National University, Daejeon, South Korea
    Br J Pharmacol 154:1125-34. 2008
    ..Despite data suggesting a link between Sig-1 Rs and NMDA receptors, there are no studies addressing whether Sig-1 R activation directly affects NMDA receptor sensitivity...
  9. pmc Functional disturbances in the striatum by region-specific ablation of NMDA receptors
    Nobuhisa Ohtsuka
    Center for Systems Neurobiology, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 105:12961-6. 2008
    ..These results demonstrate that the NMDA receptor plays an essential role in the integration of dopamine signaling in the striatum and that is required in behavioral function...
  10. pmc Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit
    I Ito
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    J Physiol 500:401-8. 1997
    ..5. These results suggest that NMDA receptors with different subunit compositions function within a single CA3 pyramidal cell in a synapse-selective manner...
  11. doi Expression and activation of N-methyl-D-aspartate receptor subunit-1 receptor subunits in gonadotrophin-releasing hormone neurones of young and middle-aged mice during the luteinising hormone surge
    V Adjan
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    J Neuroendocrinol 20:1147-54. 2008
    ..ageing, we measured the expression and activation of the mandatory N-methyl-D-aspartate receptor subunit-1 (NMDAR1) in GnRH neurones of young and middle-aged mice prior to and during a steroid-induced LH surge...
  12. ncbi Developmental changes in distribution of NMDA receptor channel subunit mRNAs
    M Watanabe
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Neuroreport 3:1138-40. 1992
    ..In contrast, the zeta 1 subunit mRNA distributes ubiquitously in the brain throughout development. These findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development...
  13. ncbi Cloning, expression and modulation of a mouse NMDA receptor subunit
    M Yamazaki
    Department of Neuropharmacology, Niigata University, Japan
    FEBS Lett 300:39-45. 1992
    ..It has been found that the zeta 1 channel activity is positively modulated by treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA)...
  14. ncbi N-methyl-D-aspartic acid receptor structure and function
    C J McBain
    Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
    Physiol Rev 74:723-60. 1994
  15. ncbi Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death
    D Forrest
    Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    Neuron 13:325-38. 1994
    In vitro studies have suggested that the NMDA receptor consists of an essential subunit, NR1, and various modulatory NR2 subunits. To test this hypothesis directly in vivo, we generated mice carrying a disrupted NR1 allele...
  16. ncbi Characterization of excitatory amino acid neurotoxicity in N-methyl-D-aspartate receptor-deficient mouse cortical neuronal cells
    Y Tokita
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    Eur J Neurosci 8:69-78. 1996
    ..Mutant mice lacking a functional NMDA receptor were generated by gene targeting of the NR1 NMDA receptor subunit...
  17. ncbi The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    J Z Tsien
    Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 87:1327-38. 1996
    We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout...
  18. ncbi Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice
    T J McHugh
    Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 87:1339-49. 1996
    ..multiple electrode recording techniques to freely behaving mice with a CA1 pyramidal cell-specific knockout of the NMDAR1 gene...
  19. ncbi Phosphorylation-dependent regulation of N-methyl-D-aspartate receptors by calmodulin
    C Hisatsune
    Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108, Japan
    J Biol Chem 272:20805-10. 1997
    ..By using the yeast two-hybrid system, we found that calmodulin interacts with the COOH terminus of the NR1 subunit and inactivates the channels in a Ca2+-dependent manner...
  20. ncbi A candidate target for G protein action in brain
    L T Chen
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9041, USA
    J Biol Chem 274:26931-8. 1999
    An effector candidate for G protein action, GRIN1, was identified by screening a cDNA expression library with phosphorylated GTPgammaS-G(z)alpha as a probe. GRIN1 is a novel protein without substantial homology to known protein domains...
  21. ncbi Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
    A R Mohn
    Department of Medicine, University of North Carolina at Chapel Hill 27599 USA
    Cell 98:427-36. 1999
    ..We report here the generation of mice expressing only 5% of normal levels of the essential NMDAR1 (NR1) subunit...
  22. ncbi Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons
    P T Huerta
    Howard Hughes Medical Institute, Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 25:473-80. 2000
    ..Work on the rodent hippocampus has shown that NMDA receptor (NMDAR) -mediated plasticity is essential for spatial memory...
  23. ncbi Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R)
    F N Single
    Max Planck Institute for Medical Research, Departments of Molecular Neuroscience and Cell Physiology, Jahnstrabetae 29, D 69120 Heidelberg, Germany
    J Neurosci 20:2558-66. 2000
    NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R)...
  24. ncbi Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site
    J N Kew
    Preclinical CNS Research and Roche Genetics, F Hoffmann La Roche Ltd, CH 4070 Basel, Switzerland
    J Neurosci 20:4037-49. 2000
    ..homologous recombination to generate two mouse lines carrying point mutations in the glycine binding site of the NMDAR1 subunit (Grin1)...
  25. ncbi NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation
    E Shimizu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Science 290:1170-4. 2000
    ..Such a synaptic reinforcement process may also serve as a cellular means by which the new memory is transferred from the hippocampus to the cortex for permanent storage...
  26. pmc Requirement for hippocampal CA3 NMDA receptors in associative memory recall
    Kazu Nakazawa
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 297:211-8. 2002
    ..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall...
  27. ncbi Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity
    Theresa M Ballard
    Preclinical CNS Research, F Hoffmann La Roche Limited, CH 4070 Basel, Switzerland
    J Neurosci 22:6713-23. 2002
    ..We previously have described two mouse lines carrying point mutations in the NMDA receptor glycine binding site, Grin1(D481N) and Grin1(K483Q), which exhibit 5- and 86-fold reductions in receptor glycine affinity, respectively...
  28. pmc NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the barrel cortex
    Akash Datwani
    Laboratory for Behavioral Genetics, Brain Science Institute BSI, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Mol Cell Neurosci 21:477-92. 2002
    ..In CxNR1KO mice, cortical excitatory neurons lack NR1, the essential subunit of the NMDAR, and in their primary somatosensory (S1) cortex whisker-specific cellular patterns, "barrels," are absent...
  29. ncbi Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling
    York Rudhard
    Wellcome Laboratory for Molecular Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:2323-32. 2003
    ..Furthermore, the NR1 N598R mutation does not affect expression levels of NMDAR subunits and other important neurotransmitter receptors...
  30. pmc Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice
    Masahiro Fukaya
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 100:4855-60. 2003
    ..mammalian central nervous system, and the N-methyl-D-aspartate-selective glutamate receptor (NR) consisting of the NR1 subunit and an NR2 or NR3 subunit plays crucial roles in synaptic transmission, plasticity, and learning and memory...
  31. ncbi Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience
    Kazu Nakazawa
    Howard Hughes Medical Institute, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 38:305-15. 2003
    ..These results suggest that CA3 NRs play a crucial role in rapid hippocampal encoding of novel information for fast learning of one-time experience...
  32. ncbi NMDA receptor-dependent ocular dominance plasticity in adult visual cortex
    Nathaniel B Sawtell
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 38:977-85. 2003
    ..These insights may force a revision in how data on ocular dominance plasticity in mutant mice have been interpreted...
  33. ncbi NMDA and beta1-adrenergic receptors differentially signal phosphorylation of glutamate receptor type 1 in area CA1 of hippocampus
    Amanda M Vanhoose
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 23:5827-34. 2003
    ..open channel probability and is permissive for both the synaptic expression of the receptor and NMDA-receptor (NMDAR)-dependent long-term potentiation (LTP)...
  34. ncbi Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain
    Zhenzhong Cui
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 USA, USA
    Neuron 41:781-93. 2004
    ..Thus, our study reveals a hitherto unrecognized role of the NMDA receptor in dynamically maintaining the long-term synaptic stability of memory storage circuits in the brain...
  35. ncbi Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function
    Gary E Duncan
    Department of Psychiatry, University of North Carolina School of Medicine, CB 7090, Chapel Hill, NC 27599 7090, USA
    Behav Brain Res 153:507-19. 2004
    ..NMDA receptor hypofunction, a mouse line was developed that expresses low levels of the NMDA R1 subunit (NR1) of the NMDA receptor...
  36. pmc NMDA receptor-dependent regulation of axonal and dendritic branching
    Li Jen Lee
    Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 25:2304-11. 2005
    ..Genetic impairment of NMDA receptor (NMDAR) function blocks development of barrelettes in the PrV. Underlying cellular and functional defects are not known...
  37. ncbi Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons
    Derya R Shimshek
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Heidelberg, Germany
    Mol Endocrinol 20:219-31. 2006
    ....
  38. ncbi Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression
    John Bradley
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141, USA
    J Neurosci 26:1065-76. 2006
    Subunits of the NMDA receptor (NMDAR) associate with many postsynaptic proteins that substantially broaden its signaling capacity...
  39. ncbi Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigation
    Laure Rondi-Reig
    College de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7152, Laboratoire de Physiologie de la Perception et de l Action, F 75005 Paris, France
    J Neurosci 26:4071-81. 2006
    ..lacking hippocampal CA1 NMDA receptors and presenting a reduction of these receptors in the deep cortical layers (NR1-KO mice)...
  40. ncbi Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome
    Mark O Collins
    Genes to Cognition, The Wellcome Trust Sanger Institute, Hinxton, UK
    J Neurochem 97:16-23. 2006
    ..nine in AMPA-receptor immuno-purifications, 100 in isolates using an antibody against the NMDA receptor subunit NR1, and 170 by peptide-affinity purification of complexes with the C-terminus of NR2B...
  41. ncbi Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function
    Sheryl S Moy
    Department of Psychiatry, and Neurodevelopmental Disorders Research Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Brain Res 1089:186-94. 2006
    Genetically altered mice with reductions in the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor have been proposed as a model for the intrinsic NMDA hypofunction hypothesized for schizophrenia...
  42. pmc From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development
    Toshiko R Matsugami
    Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Proc Natl Acad Sci U S A 103:12161-6. 2006
    ....
  43. ncbi NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
    Ayumu Tashiro
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 442:929-33. 2006
    ..This information-specific addition of new circuits through selective survival or death of new neurons may be a unique attribute of new neurons that enables them to play a critical role in learning and memory...
  44. ncbi CA3 NMDA receptors are crucial for rapid and automatic representation of context memory
    Catherine J Cravens
    Unit on Genetics of Cognition and Behaviour, Mood and Anxiety Disorders Research Program, National Institute of Mental Health, Bethesda, MD 20892 3710, USA
    Eur J Neurosci 24:1771-80. 2006
    ..It appears that rapid and automatic context memory representations from one-time experience are mediated, at least in part, by CA3 NMDA receptors...
  45. pmc Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum
    Mai T Dang
    Department of Molecular and Integrative Physiology, NeuroTech Group, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 103:15254-9. 2006
    ..To examine the role of striatal NMDAR in motor learning, we created striatum-specific NMDAR1 subunit knockout mice, analyzed the striatal anatomy and neuronal morphology of these mice, evaluated their ..
  46. pmc Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus
    B Niewoehner
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Eur J Neurosci 25:837-46. 2007
    ..Here we generated genetically modified mice (NR1(deltaDG) mice) exhibiting complete loss of the NR1 subunit of the N-methyl-D-aspartate receptor specifically in the ..
  47. ncbi Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
    ..a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1, specifically in dentate gyrus granule cells...
  48. ncbi Early auditory sensory processing deficits in mouse mutants with reduced NMDA receptor function
    Stephan Bickel
    Department of Neuroanatomy, Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Neuropsychopharmacology 33:1680-9. 2008
    ..We tested the paradigms mentioned in mouse mutants with reduced expression of the NR1 subunit of the NMDA receptor (N = 15) and their wild-type littermates (N = 16)...
  49. pmc Development of a mouse test for repetitive, restricted behaviors: relevance to autism
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 188:178-94. 2008
    ..Four inbred mouse strains, C57BL/6J, BALB/cByJ, BTBR T+tf/J, and FVB/NJ, and mice with reduced expression of Grin1, leading to NMDA receptor hypofunction (NR1neo/neo mice), were tested for exploration and preference for olfactory ..
  50. doi NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors
    María Rodríguez-Muñoz
    Department of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Madrid, Spain
    Cell Signal 20:1855-64. 2008
    ..The N-methyl-D-aspartate receptor (NMDAR) antagonist, MK801, also prevented PKCgamma recruitment to MORs and serine phosphorylation of the receptors ..
  51. pmc Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors
    Larry S Zweifel
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Neuron 59:486-96. 2008
    A single exposure to drugs of abuse produces an NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of AMPA receptor (AMPAR) currents in DA neurons; however, the importance of LTP for various aspects of drug addiction is unclear...
  52. doi Glutamate receptors on dopamine neurons control the persistence of cocaine seeking
    David Engblom
    Division of Molecular Biology of the Cell I, German Cancer Research Center, 69120 Heidelberg, Germany
    Neuron 59:497-508. 2008
    ..Here, we generated mice lacking the GluR1, GluR2, or NR1 receptor subunits selectively in dopamine neurons...
  53. pmc Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia
    T B Halene
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genes Brain Behav 8:661-75. 2009
    ..Clinical and experimental evidence suggests a dysregulation of NMDAR function and glutamatergic pathways in the pathophysiology of schizophrenia...
  54. pmc Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death
    Seiichiro Jinde
    Unit on the Genetics of Cognition and Behavior, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, MD 20892, USA
    Eur J Neurosci 30:1036-55. 2009
    ....
  55. pmc Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice
    V Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Genes Brain Behav 9:11-25. 2010
    Reduced function of the N-methyl-d-aspartate receptor (NMDAR) has been implicated in the pathophysiology of schizophrenia...
  56. pmc NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity
    Bo Li
    The Rockefeller University, New York, New York 10021, USA
    J Neurosci 29:11965-72. 2009
    ..This knock-in mutation causes severe impairment in NMDAR synaptic incorporation and NMDAR-mediated synaptic transmission...
  57. pmc Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
    Juan E Belforte
    Unit on Genetics of Cognition and Behavior, Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 13:76-83. 2010
    ..Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was selectively eliminated in 40-50% of cortical and hippocampal interneurons in early postnatal development...
  58. doi Phenotypic characterization of a new Grin1 mutant mouse generated by ENU mutagenesis
    Tamio Furuse
    Technology and Development Team for Mouse Phenotype Analysis Japan Mouse Clinic, RIKEN BioResource Center, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Eur J Neurosci 31:1281-91. 2010
    ..males treated with ENU and untreated DBA/2J females in the open-field test and isolated behavioral mutant M100174, which exhibited a significant increase in spontaneous locomotor activity...
  59. pmc Start/stop signals emerge in nigrostriatal circuits during sequence learning
    Xin Jin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892 9412, USA
    Nature 466:457-62. 2010
    ..These results have important implications for understanding the functional organization of actions and the sequence initiation and termination impairments observed in basal ganglia disorders...
  60. doi NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory
    Tatiana Korotkova
    Department of Clinical Neurobiology, IZN, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Neuron 68:557-69. 2010
    ..and behavioral deficits in mice with selective ablation of NMDA receptors in parvalbumin-positive interneurons (NR1(PVCre-/-))...
  61. pmc Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization
    Lisa R Beutler
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:4206-11. 2011
    ..Here we use selective inactivation of Grin1, the gene encoding the essential NR1 subunit of NMDARs, in dopamine neurons or their medium spiny neuron (MSN) ..
  62. pmc A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
    M Carlen
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, MIT, Cambridge, MA 02139, USA
    Mol Psychiatry 17:537-48. 2012
    ..The disruption of NMDA receptor (NMDAR) signaling specifically in FS PV interneurons is therefore hypothesized to give rise to neural network dysfunction ..
  63. pmc Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism
    M Ali Bangash
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 145:758-72. 2011
    ..density proteins, spine morphology, and synapse number are unchanged in Shank3(+/ΔC) mice, but the amplitude of NMDAR responses is reduced together with reduced NMDAR-dependent LTP and LTD...
  64. pmc The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning
    Jones G Parker
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 31:11362-9. 2011
    ..To better understand where NMDAR signaling is necessary for learning, we combined viral genetic strategies with genetic mouse models to investigate ..
  65. pmc NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination
    Lindsay M De Biase
    The Solomon H Snyder Department of Neuroscience and Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 31:12650-62. 2011
    ..Although glutamate influences the proliferation and maturation of these progenitors in vitro, the role of NMDAR signaling in oligodendrogenesis and myelination in vivo is not known...
  66. pmc Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo
    John A Gray
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Neuron 71:1085-101. 2011
    ..Similar to GluN1, GluN2B deletion increases the number of functional synapses, while GluN2A deletion increases the strength of ..
  67. pmc NMDA receptors in dopaminergic neurons are crucial for habit learning
    Lei Phillip Wang
    Brain and Behavior Discovery Institute and Department of Neurology, Georgia Health Sciences University, Augusta, GA 30912, USA
    Neuron 72:1055-66. 2011
    ..Here, we show that mice with dopaminergic neuron-specific NMDAR1 deletion are impaired in a variety of habit-learning tasks, while normal in some other dopamine-modulated ..
  68. pmc Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development
    Fuzheng Guo
    Institute for Pediatric Regenerative Medicine, University of California, Davis, School of Medicine and Shriners Hospital, Sacramento, California 95817, USA
    J Neurosci 32:639-45. 2012
    ..autoimmune encephalomyelitis (EAE), a model of human MS, by timed conditional disruption of oligodendroglial NR1, an essential subunit of functional NMDARs, using an inducible proteolipid protein (Plp) promoter-driven Cre-loxP ..
  69. pmc GluN1 hypomorph mice exhibit wide-ranging behavioral alterations
    C Barkus
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK
    Genes Brain Behav 11:342-51. 2012
    ..b>GluN1 'hypomorph' (GluN1(hypo) ) mice exhibit reduced NMDA receptor expression and have been suggested as a mouse model ..
  70. pmc Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion
    David M Bannerman
    Department of Experimental Psychology, University of Oxford, Oxford, UK
    Nat Neurosci 15:1153-9. 2012
    ..Here we show that Grin1(ΔDGCA1) mice, lacking GluN1 and hence NMDARs in all dentate gyrus and dorsal CA1 principal cells, acquired the ..
  71. ncbi Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout
    Zhenzhong Cui
    Center for Systems Neurobiology, Department of Pharmacology, Boston University, Boston, MA 02118, USA
    Eur J Neurosci 22:755-63. 2005
    ..and region-specific gene knockout technique to investigate the requirements for cortical NMDA receptors (NMDAR) during the various stages (acquisition, consolidation and storage, and retrieval) of nondeclarative, hippocampal-..
  72. pmc Regulation of spine morphology and spine density by NMDA receptor signaling in vivo
    Sila K Ultanir
    Neurobiology Section, Division of Biological Sciences, and National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:19553-8. 2007
    ..Genetic deletion of the NR1 subunit of the NMDA receptor in the cortex leads to a decrease in spine density and an increase in spine head size ..
  73. ncbi Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum
    M Watanabe
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    J Comp Neurol 343:513-9. 1994
    ..These findings suggest that anatomical organization of the epsilon subunits is heterogeneous in the cerebellum both spatially and temporally, which would give rise to functional diversity of the NMDA receptor channel...
  74. pmc Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity
    Joju George
    Department of Pharmacology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Proc Natl Acad Sci U S A 109:19840-5. 2012
    ..Intracellular sodium ([Na(+)](i)) also exerts a regulatory influence on NMDAR channel activity, and [Na(+)](i) may, therefore, function as a signaling molecule...
  75. ncbi Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule
    P L Chazot
    Department of Pharmaceutical Chemistry, School of Pharmacy, London, United Kingdom
    J Biol Chem 269:24403-9. 1994
    ..These results show that the three NMDA receptor subunit types can co-assemble following their co-expression in mammalian cells with a pharmacological profile that is similar to that found for adult cerebellar NMDA receptors...
  76. ncbi Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel
    H Takano
    Department of Neurology, Niigata University, Japan
    Biochem Biophys Res Commun 197:922-6. 1993
    ..By the fluorescence in situ hybridization, we mapped the genes for the epsilon 1, epsilon 3 and zeta 1 subunits of the human NMDA receptor channel to chromosomes 16p13, 17q25 and 9q34, respectively...
  77. ncbi Differential expression and co-assembly of NMDA zeta 1 and epsilon subunits in the mouse cerebellum during postnatal development
    M Didier
    Laboratories for Molecular Neuroscience, McLean Hospital, Belmont, MA 02178, USA
    Neuroreport 6:2255-9. 1995
    ..The time course of their expression suggest, that these NMDA receptor subtypes may contribute to specific aspects of granule cell differentiation in the cerebellum...
  78. ncbi Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene
    A K Ebralidze
    Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139 4307, USA
    J Neurosci 16:5014-25. 1996
    ....
  79. ncbi Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene
    P W Chiang
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA
    Genomics 34:368-75. 1996
    ..g., such as most histones), in all fetal and adult tissues that we examined...
  80. ncbi Expression of the alpha 4 neuronal nicotinic acetylcholine receptor subunit in the developing mouse hippocampus
    M Didier
    Laboratories for Molecular Neuroscience, Harvard Medical School McLean Hospital, Belmont, MA 02178, USA
    Int J Dev Neurosci 13:703-13. 1995
    ..The transient profile of alpha 4 expression suggests that nAChRs may participate in the early postnatal maturation of hippocampal circuity...
  81. ncbi Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion
    L D Snell
    Department of Pharmacology C236, University of Colorado Health Sciences Center, Denver 80262, USA
    Brain Res Mol Brain Res 40:71-8. 1996
    ..by mice, which results in the generation of physical dependence, also produces increases in the NMDA receptor NR1 subunit protein in the hippocampus and cerebellum (approximately 50% and 95%, respectively), and produces increases ..
  82. ncbi Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo
    R Sprengel
    Max Planck Institute for Medical Research, Department of Molecular Neuroscience, Heidelberg, Germany
    Cell 92:279-89. 1998
    ..C-terminal truncation of NR2 subunits does not interfere with the formation of gateable receptor channels that can be synaptically activated. Thus, the phenotypes of our mutants appear to reflect defective intracellular signaling...
  83. pdf NMDA receptor activity in utero averts respiratory depression and anomalous long-term depression in newborn mice
    C S Poon
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 20:RC73. 2000
    Mutant mice lacking NMDA receptor 1 subunit (NR1) showed marked depression of respiratory and suckling activities in vivo and overexpression of synaptic long-term depression (LTD) in a brainstem cardiorespiratory-related region (nucleus ..
  84. ncbi Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport
    M Setou
    Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Science 288:1796-802. 2000
    ..This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis...
  85. ncbi Neural cells without functional N-Methyl-D-Aspartate (NMDA) receptors contribute extensively to normal postnatal brain development in efficiently generated chimaeric NMDA R1 -/- <--> +/+ mice
    U Maskos
    Laboratory of Molecular Biology, NINDS NIH, Bethesda, MD 20892 4092, USA
    Dev Biol 262:119-36. 2003
    ..The NMDA receptor subunit 1 (NR1) gene is indispensable for receptor function, and knock-out mice die at birth, inhibiting the study of glutamate ..
  86. ncbi Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 340:435-40. 2006
    ..contextual memory and LTP and, unexpectedly, in reductions of the surface expression of NMDA receptor (NMDAR) subunit NR1 and NMDAR-mediated excitatory post-synaptic currents at hippocampal perforant path-dentate granule ..
  87. ncbi Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites
    Valery Krizhanovsky
    Department of Cell and Animal Biology, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Mol Neurosci 28:211-29. 2006
    ..Our findings may be useful to the study of other bHLH transcription factors, many of which control the development of the nervous system...
  88. pmc Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia
    Karni S Moshal
    Department of Physiology and Biophysics, Potentia Pharmaceuticals, Louisville, KY, USA
    Am J Physiol Heart Circ Physiol 295:H890-7. 2008
    ..We conclude that HHCY activates mtMMP-9 and induces MPT, leading to myocyte mechanical dysfunction by agonizing NMDA-R1...
  89. pmc Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress
    Gary E Duncan
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res 1265:186-95. 2009
    Mice with reduced expression of the NR1 subunit of the NMDA receptor (NR1 hypomorphic mice) display altered behavioral phenotypes that may relate to behavioral characteristics of schizophrenia...
  90. pmc Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system
    Claudia S Barros
    Department of Cell Biology, Institute of Childhood and Neglected Disease, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:4507-12. 2009
    ..We conclude that ErbB2/B4-mediated NRG1 signaling modulates dendritic spine maturation, and that defects at glutamatergic synapses likely contribute to the behavioral abnormalities in ErbB2/B4-deficient mice...
  91. pmc PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex
    Jingping Zhang
    New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Neurosci 29:2948-60. 2009
    ..prototypical structural and signaling scaffold in the postsynaptic density, inhibits D(1)-NMDA receptor subunit 1 (NR1) NMDA receptor association and uncouples NMDA receptor-dependent enhancement of D(1) signaling...
  92. pmc Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis
    Stefan Kindler
    Institute of Human Genetics, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    J Biol Chem 284:25431-40. 2009
    ..Our data suggest that local synthesis in dendrites may be necessary to replenish dendritic Jacob pools after truncation of the N-terminal membrane anchor and concomitant translocation of Jacob to the nucleus...
  93. pmc CA3 NMDA receptors are required for the rapid formation of a salient contextual representation
    Thomas J McHugh
    The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Hippocampus 19:1153-8. 2009
    ..By subjecting CA3-NR1 KO mice to conditioning protocols that incorporate time-dependent components, we found that the loss of plasticity ..
  94. pmc Absence of NMDA receptors in dopamine neurons attenuates dopamine release but not conditioned approach during Pavlovian conditioning
    Jones G Parker
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle WA 98195, USA
    Proc Natl Acad Sci U S A 107:13491-6. 2010
    ..transmission, we tested mice lacking NMDA-type glutamate receptors (NMDARs) exclusively in dopamine neurons (NR1-KO mice). Surprisingly, NR1-KO mice learned at the same rate as their littermate controls...
  95. pmc NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization
    Yu Luo
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e12141. 2010
    ..sensitization to cocaine and other psychomotor stimulants is thought to reflect N-methyl-D-aspartate receptor (NMDAR)-mediated synaptic plasticity in the mesolimbic dopamine (DA) circuitry...
  96. pmc Glutamatergic signaling maintains the epithelial phenotype of proximal tubular cells
    Milica Bozic
    Nephrology Research Laboratory, IRB Lleida, University Hospital Arnau de Vilanova, Lleida, Spain
    J Am Soc Nephrol 22:1099-111. 2011
    ..Here, knockdown of NMDAR1 in a proximal tubule cell line (HK-2) induced changes in cell morphology, reduced E-cadherin expression, and ..
  97. ncbi Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons
    X J Hu
    Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284 7764, USA
    Brain Res Mol Brain Res 36:211-8. 1996
    ..The altered NMDA receptor gene expression may be responsible for the observed upregulation of the NMDA receptor binding and function in the cortical neurons following chronic ethanol exposure...
  98. ncbi Modified N-methyl-D-aspartate receptor subunit expression emerges in reeler Purkinje cells after accomplishment of the adult wild-type expression
    M Watanabe
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Neurosci Res 26:335-43. 1996
    ..The present results further indicate that the onset of the modified expression is subsequent to the establishment of synaptic connectivities in the cerebellum...
  99. ncbi Gene structure and chromosomal localization of the mouse NMDA receptor channel subunits
    M Nagasawa
    Department of Neuropharmacology, Niigata University, Japan
    Brain Res Mol Brain Res 36:1-11. 1996
    ..Each of these genes mapped to a single chromosome location. The mapping results assigned the five loci to five different mouse autosomes, indicating that they have become well dispersed among mouse chromosomes...
  100. ncbi Characterization of L-homocysteate-induced currents in Purkinje cells from wild-type and NMDA receptor knockout mice
    M Yuzaki
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Neurophysiol 82:2820-6. 1999
    ..HCA also activated responses mediated by non-NMDA receptors in both wild-type and NR1(-/-) hippocampal neurons...
  101. ncbi NMDA and AMPA glutamate receptor subtypes in the thoracic spinal cord in lean and obese-diabetic ob/ob mice
    N Li
    Department of Physiology, Medical School, University of Birmingham, Birmingham, UK
    Brain Res 849:34-44. 1999
    ..The increase in expression of the glutamate receptor subtypes, and altered ligand affinity for the NMDA receptor subtype in the obese mice may be causally involved in the peripheral neuropathies which can accompany diabetes mellitus...

Research Grants19

  1. Integrative Models of Neural Adaptive Control
    Chi Sang Poon; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2007
    ..assess behavioral and brain metabolic phenotypes in a genetic model of reduced NMDA receptor function-the NMDA R1 (NR1) subunit deficient mouse...
  3. ELEMENTARY SCHOOL NEUROSCIENCE LITERACY
    Gary Duncan; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  4. MODEL OF SCHIZOPHRENIA--ROLE OF CORTICAL DOPAMINE
    JANET FINLAY; Fiscal Year: 2002
    ..abstract_text> ..
  5. Opioids and Conditional Amygdala NMDA Receptor Knockout
    Michael Glass; Fiscal Year: 2007
    ..The projects in this proposal will address the role of amygdala gene expression of the essential NMDA-NR1 (NR1) receptor subunit in the development and expression of opiate dependence by creating spatial-temporal ..
  6. INIA: Neurohistology
    ANDREA ELBERGER; Fiscal Year: 2006
    ..The final product produced by the Core will be tissue sections on microscope slides with appropriate coding to track each case. A database will be maintained in the Core to assure accuracy of data analyses. ..
  7. Neuromorphic Electronic Model of Synaptic Plasticity
    Chi Sang Poon; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. Nonlinear Analysis of Heart Rate Variability
    Chi Sang Poon; Fiscal Year: 2009
    ..These clinical and modeling studies in turn will showcase the proposed analytical techniques thereby paving the way for their application to other complex biomedical modeling and analysis problems in general. ..
  9. Reconsolidation and extinction processes in the treatment of drug addiction
    Yossef Itzhak; Fiscal Year: 2010
    ..abstract_text> ..
  10. Substituted Amphetamines: NO-Dependent Mechanisms
    Yossef Itzhak; Fiscal Year: 2005
    ....
  11. Xth Oxford Conference on Modeling and Control of Breathing
    Chi Sang Poon; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  12. Chronic Stress and Visceral Nociception
    JAMES MCROBERTS; Fiscal Year: 2005
    ..These proposed experiments should also establish whether chronic psychological stress in rats is a reasonable model of chronic stress mediated symptom exacerbations in IBS patients. ..
  13. SYNAPTIC MECHANISMS IN RESPIRATORY CONTROL
    Chi Sang Poon; Fiscal Year: 2002
    ..Five specific aims are proposed to investigate these mechanisms. The results obtained will provide valuable insights into the mechanisms of afferent signal integration in the NTS and the corresponding effects on respiratory control. ..
  14. Pathways to Alcohol Tolerance
    Boris Tabakoff; Fiscal Year: 2006
    ..In all, our studies should provide an excellent foundation for understanding the neuroadaptive processes leading to ethanol tolerance in reference to the anxiolytic action of this drug. ..
  15. Adolescent Exposure to Psychostimulants: Role of nNOS
    Yossef Itzhak; Fiscal Year: 2008
    ..Results of these studies would provide new information on mechanisms that underlie the development of hypersensitivity to these drugs from adolescence through adulthood. ..
  16. Genetic Dissection of Brain Reward Circuits
    LARRY ZWEIFEL; Fiscal Year: 2008
    ..that lead to drug seeking behavior are thought to involve signaling through the NMDA-type glutamate receptor (NMDAR), however virtually nothing is known about the cell-specific requirements of this signal transduction cascade ..
  17. Peripheral NMDA receptors in visceral nociception
    JAMES MCROBERTS; Fiscal Year: 2009
    ..sensitization relies crucially on the activation of a particular type of glutamate receptor, the NMDA receptor (NMDAR), located on postsynaptic neurons in the dorsal horn of the spinal cord...
  18. Endocannabinoids in COX-2-Mediated Synaptic Modification and Neurotoxicity
    Chu Chen; Fiscal Year: 2010
    ..The outcome from the proposed project will also provide new targets for designing drugs aimed at treating or alleviating COX-2-mediated degenerative diseases. ..
  19. Pontomedullary Integration of Respiratory Afferents
    Chi Sang Poon; Fiscal Year: 2010
    ....