Gria1

Summary

Gene Symbol: Gria1
Description: glutamate receptor, ionotropic, AMPA1 (alpha 1)
Alias: 2900051M01Rik, Glr-1, Glr1, GluA1, GluR-A, GluRA, Glur-1, Glur1, HIPA1, gluR-K1, glutamate receptor 1, AMPA-selective glutamate receptor 1, glutamate receptor A, glutamate receptor ionotropic, AMPA 1
Species: mouse

Top Publications

  1. ncbi Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8574, Japan
    Brain Res 1093:1-11. 2006
  2. ncbi Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior
    Elke C Fuchs
    Department of Clinical Neurobiology, University Hospital of Neurology, IZN, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Neuron 53:591-604. 2007
  3. ncbi Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memory
    D J Sanderson
    Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
    Behav Neurosci 121:559-69. 2007
  4. pmc Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity
    Geun Hee Seol
    The Mind Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuron 55:919-29. 2007
  5. ncbi Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking
    Hailan Hu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 131:160-73. 2007
  6. pmc Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:21888-901. 2010
  7. pmc Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3
    Nathalie Strutz-Seebohm
    Department of Physiology I, University of Tuebingen, 72076 Tuebingen, Germany
    J Physiol 565:381-90. 2005
  8. pmc Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity
    Yelyzaveta A Nikandrova
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:923-34. 2010
  9. ncbi Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons
    Fumio Ogoshi
    Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697 4292, USA
    Exp Neurol 193:384-93. 2005
  10. ncbi Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning
    Alexander W Johnson
    School of Psychology, Cardiff University, UK
    Behav Neurosci 121:1192-202. 2007

Scientific Experts

Detail Information

Publications126 found, 100 shown here

  1. ncbi Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8574, Japan
    Brain Res 1093:1-11. 2006
    ..Furthermore, immunoblot analysis revealed that EFA6D was highly concentrated in the postsynaptic density fraction. These findings suggest differential spatiotemporal regulation of ARF6 by three members of the EFA6 family in the brain...
  2. ncbi Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior
    Elke C Fuchs
    Department of Clinical Neurobiology, University Hospital of Neurology, IZN, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Neuron 53:591-604. 2007
    ..These findings directly show the effects of insufficient recruitment of fast-spiking cells at the network and behavioral level and demonstrate the role of this subpopulation for working and episodic-like memory...
  3. ncbi Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memory
    D J Sanderson
    Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
    Behav Neurosci 121:559-69. 2007
    Genetically modified mice lacking the glutamate receptor A (GluR-A) subunit of the AMPA receptor (GluR-A-/- mice) display normal spatial reference memory but impaired spatial working memory (SWM)...
  4. pmc Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity
    Geun Hee Seol
    The Mind Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuron 55:919-29. 2007
    ..These findings indicate that cholinergic and adrenergic neuromodulation associated with the behavioral state of the animal can control the gating and the polarity of cortical plasticity...
  5. ncbi Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking
    Hailan Hu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 131:160-73. 2007
    ..Toward this aim, we have examined the role of NE in contextual memory formation and in the synaptic delivery of GluR1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-type glutamate receptors during long-..
  6. pmc Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:21888-901. 2010
    ..of SAPAP3 did not affect surface expression of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) GluR1 receptors induced by D1 receptor activation but impaired their subsequent internalization in cultured PFC neurons; ..
  7. pmc Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3
    Nathalie Strutz-Seebohm
    Department of Physiology I, University of Tuebingen, 72076 Tuebingen, Germany
    J Physiol 565:381-90. 2005
    ..In Xenopus oocytes expressing the AMPA subunit GluR1, we show that SGK3, and to a lesser extent SGK2, but not SGK1, increase glutamate-induced currents by increasing ..
  8. pmc Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity
    Yelyzaveta A Nikandrova
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:923-34. 2010
    Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) promotes trafficking and activation of the GluR1 subunit of alpha-amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) during synaptic plasticity...
  9. ncbi Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons
    Fumio Ogoshi
    Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697 4292, USA
    Exp Neurol 193:384-93. 2005
    ..factor-alpha (TNF-alpha) was shown to increase the cell surface expression of an AMPA receptor (AMPAR) subunit (GluR1) and to potentiate vulnerability to AMPAR-mediated injury...
  10. ncbi Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning
    Alexander W Johnson
    School of Psychology, Cardiff University, UK
    Behav Neurosci 121:1192-202. 2007
    ..The results support the hypothesis that GluR-1 deletion impairs the associative activation of a representation of the sensory-specific incentive motivational properties of an appetitive reward...
  11. pmc A role for alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid GluR1 phosphorylation in the modulatory effects of appetitive reward cues on goal-directed behavior
    Hans S Crombag
    Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, The Johns Hopkins University, Baltimore, MD, USA
    Eur J Neurosci 27:3284-91. 2008
    ..Using homologous recombination (knock-in) techniques we targeted two phosphorylation sites on the AMPA-GluR1 receptor: the Ser831 site, phosphorylated by calcium calmodulin-dependent protein kinase II/protein kinase C, and ..
  12. ncbi Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse
    Yasushi Ohkubo
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 24:6057-69. 2004
    ..We conclude that Fgfr1 is necessary for hippocampal growth, because it promotes the proliferation of hippocampal progenitors and stem cells during development...
  13. ncbi Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor
    Shigeo Uchino
    Department of Neurochemistry, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    J Neurochem 97:1203-14. 2006
    ..of AMPA receptor trafficking, we performed a yeast two-hybrid screening system using the cytoplasmic tail of the GluR1 subunit of AMPA receptor as a bait and identified a synaptic molecule, Shank3/ProSAP2, as a GluR1 subunit-..
  14. ncbi A synaptic model of memory: long-term potentiation in the hippocampus
    T V Bliss
    Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK
    Nature 361:31-9. 1993
    ....
  15. ncbi Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning
    D Zamanillo
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Science 284:1805-11. 1999
    ..The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory...
  16. ncbi Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer
    K Hashimoto
    Department of Physiology, Jichi Medical School, Minamikawachi Machi, Tochigi Ken 329 0498, Japan
    J Neurosci 19:6027-36. 1999
    ..These results suggest that the defect in MF to GC synaptic transmission is a major factor that causes the cerebellar dysfunction in the stg mutant mouse...
  17. ncbi Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits
    O Y Vekovischeva
    Department of Pharmacology and Clinical Pharmacology, University of Turku, FIN 20520 Turku, Finland
    J Neurosci 21:4451-9. 2001
    ..The results indicate that AMPA receptors are involved in the acute and chronic effects of morphine, including context-independent sensitization, and that the GluR-A subunit itself is important for morphine tolerance and dependence...
  18. ncbi Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice
    V Mack
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Science 292:2501-4. 2001
    ..is dependent on l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit...
  19. pmc Molecular dissection of hippocampal theta-burst pairing potentiation
    D A Hoffman
    Abteilung Zellphysiologie and Molekulare Neurobiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 99:7740-5. 2002
    ..The two components of synaptic potentiation could be relevant for different forms of information storage that are dependent on hippocampal synaptic transmission such as spatial reference and working memory...
  20. ncbi Spatial memory dissociations in mice lacking GluR1
    D Reisel
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
    Nat Neurosci 5:868-73. 2002
    Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation...
  21. ncbi Selective disruption of stimulus-reward learning in glutamate receptor gria1 knock-out mice
    Andy N Mead
    Laboratory of Experimental Psychology, University of Sussex, Brighton BN1 9QG, United Kingdom
    J Neurosci 23:1041-8. 2003
    ..AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP)...
  22. ncbi Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory
    Hey Kyoung Lee
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Cell 112:631-43. 2003
    ..We previously reported that phosphorylation of the GluR1 subunit of AMPA receptors, which mediate rapid excitatory transmission in the brain, is modulated during LTP and ..
  23. ncbi A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient mice
    Wolfram B Schmitt
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 23:3953-9. 2003
    Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluRA) (GluR1) and wild-type controls were compared on a radial-maze task in which the same three of six arms were always baited, but in which the rewards of milk ..
  24. pmc Impaired regulation of synaptic strength in hippocampal neurons from GluR1-deficient mice
    Bertalan K Andrasfalvy
    Neuroscience Center, Louisiana State University Health Science Center, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 552:35-45. 2003
    ..In fact, glutamate receptor 1 (GluR1 or GluRA) subunits containing L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) ..
  25. pmc A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A
    Vidar Jensen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103 Blindern, N0317 Oslo, Norway
    J Physiol 553:843-56. 2003
    ..Our results show that in the developing hippocampus synaptic plasticity can be expressed by AMPA receptors lacking the GluR-A subunit...
  26. ncbi Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 23:9367-73. 2003
    ..Our data indicate that in the absence of GluR2, aberrant receptor complexes composed of GluR1 and GluR3 are formed in the hippocampus, and that there is an increased number of homomeric GluR1 and GluR3 ..
  27. ncbi The role of hippocampal glutamate receptor-A-dependent synaptic plasticity in conditional learning: the importance of spatiotemporal discontiguity
    Wolfram B Schmitt
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 24:7277-82. 2004
    Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluR-A or GluR1) and mice with cytotoxic hippocampal lesions were compared with wild-type and sham-operated controls, respectively, on a conditional learning task ..
  28. ncbi Reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient mice
    O Y Vekovischeva
    Institute of Biomedicine Pharmacology, Biomedicum Helsinki, University of Helsinki, Finland
    Genes Brain Behav 3:253-65. 2004
    ....
  29. ncbi The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain
    Bettina Hartmann
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Neuron 44:637-50. 2004
    ..Thus, AMPA receptors are not mere determinants of fast synaptic transmission underlying basal pain sensitivity as previously thought, but are critically involved in activity-dependent changes in synaptic processing of nociceptive inputs...
  30. ncbi Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice
    Andy N Mead
    Department of Psychology, School of Life Sciences, University of Sussex, BN1 9QG, UK
    Psychopharmacology (Berl) 179:164-71. 2005
    ..Critically, this classical conditioning procedure requires the formation of associations between a rewarding stimulus and environmental cues, and the ability of these cues to direct subsequent behaviour...
  31. ncbi Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice
    W B Schmitt
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
    Nat Neurosci 8:270-2. 2005
    Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial ..
  32. ncbi Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression
    Lenora J Volk
    Center for Basic Neuroscience, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    J Neurophysiol 95:2427-38. 2006
    ..This suggests different receptors and/or upstream mechanisms for chemically and synaptically induced LTD...
  33. ncbi Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors
    L M Wiedholz
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD 20852, USA
    Mol Psychiatry 13:631-40. 2008
    ..study evaluated knockout (KO) mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) GluR1 receptor subunit for a range of behaviors considered relevant to certain symptoms of schizophrenia...
  34. pmc Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors
    Hey Kyoung Lee
    Howard Hughes Medical Institute, Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Mol Cell Neurosci 36:86-94. 2007
    ..Here, we identified threonine-840 (T840) on the GluR1 subunit of AMPA receptors as a novel phosphorylation site...
  35. ncbi A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning
    Yann Humeau
    Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
    J Neurosci 27:10947-56. 2007
    The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning...
  36. pmc NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840
    Jary Y Delgado
    Interdepartmental PhD Program for Neuroscience, University of California, Los Angeles, 90095, USA
    J Neurosci 27:13210-21. 2007
    ..Although three previously identified phosphorylation sites in AMPA receptor glutamate receptor 1 (GluR1) subunits (S818, S831, and S845) appear to have important roles in LTP and LTD, little is known ..
  37. doi Glutamate receptors on dopamine neurons control the persistence of cocaine seeking
    David Engblom
    Division of Molecular Biology of the Cell I, German Cancer Research Center, 69120 Heidelberg, Germany
    Neuron 59:497-508. 2008
    Cocaine strengthens excitatory synapses onto midbrain dopamine neurons through the synaptic delivery of GluR1-containing AMPA receptors...
  38. doi FMRP acts as a key messenger for dopamine modulation in the forebrain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON M5S1A8, Canada
    Neuron 59:634-47. 2008
    ..AMPA glutamate receptor subtype 1 (GluR1) surface expression and phosphorylation in response to D1 receptor stimulation were reduced in cultured Fmr1(-/-) ..
  39. pmc Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity
    Bita Maghsoodi
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 105:16015-20. 2008
    ..transmission by stimulating in dendrites the local translation and synaptic insertion of the AMPA receptor subunit GluR1. We have previously shown that all-trans retinoic acid (RA) mediates activity blockade-induced synaptic scaling by ..
  40. pmc Postsynaptic action potentials are required for nitric-oxide-dependent long-term potentiation in CA1 neurons of adult GluR1 knock-out and wild-type mice
    Keith G Phillips
    Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK
    J Neurosci 28:14031-41. 2008
    ..potentiation (LTP) consists of both presynaptic and postsynaptic components that rely on nitric oxide (NO) and the GluR1 subunit of the AMPA receptor, respectively...
  41. pmc Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus
    Carola Romberg
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Eur J Neurosci 29:1141-52. 2009
    ..Here we used genetically modified mice lacking the GluA1 subunit (Gria1(-/-) mice) to investigate GluA1-independent mechanisms of LTP at CA3-CA1 synapses in transverse hippocampal slices...
  42. doi Activity pattern-dependent long-term potentiation in neocortex and hippocampus of GluA1 (GluR-A) subunit-deficient mice
    Marco C Frey
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Neurosci 29:5587-96. 2009
    The AMPA receptor subunit GluA1 (GluR-A) has been implicated to be critically involved in the expression of long-term potentiation (LTP) and memory formation. Mice lacking this subunit possess a profound spatial working memory deficit...
  43. pmc Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach
    Wei Lu
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:254-68. 2009
    ..is of particular importance with regard to AMPA-type glutamate receptors, the multimeric complexes assembled from GluA1-A4 subunits, as the trafficking of these receptors into and out of synapses is proposed to depend upon the subunit ..
  44. pmc Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: evidence for a dual-process memory model
    David J Sanderson
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    Learn Mem 16:379-86. 2009
    The GluA1 AMPA receptor subunit is a key mediator of hippocampal synaptic plasticity and is especially important for a rapidly-induced, short-lasting form of potentiation...
  45. pmc Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation
    Da Ting Lin
    Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 12:879-87. 2009
    ..By directly visualizing individual insertion events of the AMPAR subunit GluR1 in rodents, we found that the protein 4.1N was required for activity-dependent GluR1 insertion...
  46. pmc TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains
    Aaron D Milstein
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:11348-51. 2009
    ....
  47. pmc Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation
    Kaiwen He
    Department of Biology, College of Chemical and Life Sciences and Neuroscience and Cognitive Science NACS Program, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 106:20033-8. 2009
    ..Certain types of neural activity can recruit Ca(2+)-permeable (CP) AMPARs, such as GluR1 homomers, to synapses likely via lateral diffusion from extrasynaptic sites...
  48. pmc Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus
    Hey Kyoung Lee
    Department of Biology, College of Chemical and Life Sciences, University of Maryland, College Park, MD, USA
    J Neurophysiol 103:479-89. 2010
    ..In particular, several lines of evidence suggest that reversible phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1, also referred to as GluA1 or GluR-A) plays a role in long-term potentiation (LTP) and long-term ..
  49. pmc A single brief burst induces GluR1-dependent associative short-term potentiation: a potential mechanism for short-term memory
    Martha A Erickson
    Brandeis University, Waltham, MA, USA
    J Cogn Neurosci 22:2530-40. 2010
    ..Sprengel, R., Seeburg, P. H., Nicholas, J., et al. Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model...
  50. pmc Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: evidence for Wagner's dual-process memory model
    David J Sanderson
    Department of Experimental Psychology, University of Oxford, Oxford, UK
    Neuropsychologia 48:2303-15. 2010
    Genetically modified mice, lacking the GluA1 AMPA receptor subunit, are impaired on spatial working memory tasks, but display normal acquisition of spatial reference memory tasks...
  51. pmc Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?
    Paul J Fitzgerald
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20852 9411, USA
    Neurobiol Dis 40:608-21. 2010
    Glutamatergic dysfunction is strongly implicated in schizophrenia and mood disorders. GluA1 knockout (KO) mice display schizophrenia- and depression-related abnormalities. Here, we asked whether GluA1 KO show mania-related abnormalities...
  52. pmc Calcium-permeable AMPA receptor dynamics mediate fear memory erasure
    Roger L Clem
    Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Science 330:1108-12. 2010
    ..A transient up-regulation of this form of plasticity, which involves phosphorylation of the glutamate receptor 1 subunit of the AMPA receptor, defines a temporal window in which fear memory can be degraded by behavioral ..
  53. doi Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice
    Chiara Procaccini
    Institute of Biomedicine Pharmacology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Eur J Neurosci 33:161-74. 2011
    Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunit-deficient (GluA1-/-) mice display novelty-induced hyperactivity, cognitive and social defects and may model psychiatric disorders, such as schizophrenia ..
  54. pmc Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory
    David J Sanderson
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    Learn Mem 18:128-31. 2011
    Deletion of the GluA1 AMPA receptor subunit selectively impairs short-term memory for spatial locations. We further investigated this deficit by examining memory for discrete nonspatial visual stimuli in an operant chamber...
  55. pmc Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memory
    David J Sanderson
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, United Kingdom
    Learn Mem 18:181-90. 2011
    Deletion of the GluA1 AMPA receptor subunit impairs short-term spatial recognition memory...
  56. pmc Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity
    Anubhuti Goel
    Department of Biology, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 6:e18264. 2011
    ..scaling in visual cortex of juvenile rodents, is accompanied by an increase in the phosphorylation of AMPAR GluR1 (or GluA1) subunit at the serine 845 (S845) site and the appearance of CP-AMPARs at synapses...
  57. pmc Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
    Xiaoming Wang
    Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
    Hum Mol Genet 20:3093-108. 2011
    ..Shank3(e4-9) mice have reduced levels of Homer1b/c, GKAP and GluA1 at the PSD, and show attenuated activity-dependent redistribution of GluA1-containing AMPA receptors...
  58. pmc Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder?
    Chris Barkus
    Department of Experimental Psychology, South Parks Road, University of Oxford, UK
    Neuropharmacology 62:1263-72. 2012
    ..We recently found that knockout (KO) mice lacking the AMPA GluA1 subunit displayed behavioral abnormalities relevant to some of the positive symptoms of these disorders...
  59. pmc Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression
    Sadegh Nabavi
    Center for Neural Circuits and Behavior, Division of Biology, Department of Neuroscience and Section of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 110:4027-32. 2013
    ..Our findings indicate that metabotropic actions of NMDARs can weaken active synapses without raising postsynaptic calcium, thereby revising and expanding the mechanisms controlling synaptic plasticity...
  60. pmc Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes
    Chikako Nakajima
    Department of Medicine II, University Hospital and University of Freiburg, 79104 Freiburg, Germany
    J Biol Chem 288:21909-23. 2013
    ..Accordingly, NMDA-induced internalization of the AMPA receptor subunit GluA1 was impaired in LRP1-deficient neurons...
  61. doi Persistent synaptic scaling independent of AMPA receptor subunit composition
    Haider F Altimimi
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
    J Neurosci 33:11763-7. 2013
    ..Similar to LTP, the GluA1 subunit has been suggested to be the requisite subunit for HSP-induced AMPAR insertion and acute treatment with ..
  62. doi Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740
    C Procaccini
    Institute of Biomedicine Pharmacology, Biomedicum Helsinki, P O B 63, FIN 00014 University of Helsinki, Finland
    Neuroscience 250:189-200. 2013
    ..As a putative model for these disorders, a mouse line lacking the GluA1 subunit (GluA1-KO) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor displays ..
  63. pmc Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)
    Nyaya Kelkar
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 100:9843-8. 2003
    ..The central nervous system abnormalities of Jip3-/- mice may be accounted for in part by a reduction in signal transduction by RhoA and its effector ROCK...
  64. ncbi Spatial reference memory in GluR-A-deficient mice using a novel hippocampal-dependent paddling pool escape task
    W B Schmitt
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Hippocampus 14:216-23. 2004
    ..modified mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit, GluR-A (GluR1), and deficient in hippocampal CA3-CA1 long-term potentiation (LTP), were assessed on a novel, hippocampal-..
  65. ncbi Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites
    Takashi Hayashi
    Howard Hughes Medical Institute, Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Neuron 47:709-23. 2005
    ..These data suggest that regulated palmitoylation of AMPA receptor subunits modulates receptor trafficking and may be important for synaptic plasticity...
  66. ncbi Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain
    L Vogt
    Institute of Biochemistry, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Mol Cell Neurosci 17:151-66. 2001
    ..Thus, calsyntenin-1 may link extracellular proteolysis in the synaptic cleft and postsynaptic Ca2+ signaling...
  67. ncbi Impaired outcome-specific devaluation of instrumental responding in mice with a targeted deletion of the AMPA receptor glutamate receptor 1 subunit
    Alexander W Johnson
    School of Psychology, Cardiff University, Cardiff CF10 3YG, United Kingdom
    J Neurosci 25:2359-65. 2005
    The present study evaluated the proposal that mice with a targeted deletion of the glutamate receptor 1 (GluR1) subunit of the AMPA receptor are impaired in using an instrumental or pavlovian signal to gain access to a representation of ..
  68. ncbi Synapse-specific regulation of AMPA receptor subunit composition by activity
    Kimberly J Harms
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:6379-88. 2005
    ..However, silenced neurons could not recruit the AMPA-type glutamate receptor subunit GluR1 as efficiently when competing with active neighbors...
  69. pmc Glutamate mediates platelet activation through the AMPA receptor
    Craig N Morrell
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Exp Med 205:575-84. 2008
    ..In contrast, platelets treated with the AMPAR antagonist CNQX or platelets derived from GluR1 knockout mice are resistant to AMPA effects...
  70. pmc Superresolution imaging of chemical synapses in the brain
    Adish Dani
    Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Neuron 68:843-56. 2010
    ..Combination with optogenetics further allowed molecular events associated with synaptic plasticity to be resolved at the single-synapse level...
  71. doi Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus
    Mathias V Schmidt
    Research Group Neurobiology of Stress, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 30:16949-58. 2010
    ..Finally, we provide evidence that genetic variations in the AMPA receptor subunit GluR1 are linked to the vulnerable phenotype...
  72. doi The tumor suppressor p53 guides GluA1 homeostasis through Nedd4-2 during chronic elevation of neuronal activity
    Kathryn A Jewett
    Department of Molecular and Integrative Physiology, School of Molecular and Cellular Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    J Neurochem 135:226-33. 2015
    ..Nedd4-2 encodes another ubiquitin E3 ligase. We identified glutamate receptor subunit 1 (GluA1), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2...
  73. ncbi Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus
    Feng Ru Tang
    Epilepsy Research Laboratory, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433
    Eur J Neurosci 21:2361-74. 2005
    Significant reduction in glutamate receptor 1 (GluR1)- and GluR2/3-immunopositive neurons was demonstrated in the hilus of the dentate gyrus in mice killed on days 1, 7 and 60 after pilocarpine-induced status epilepticus (PISE)...
  74. pmc Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses
    Chiara Verpelli
    Department of Pharmacology, CNR Institute of Neuroscience, University of Milan, Milan 20129, Italy
    J Biol Chem 286:34839-50. 2011
    ....
  75. pmc Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
    Nicola J Allen
    Stanford University School of Medicine, Department of Neurobiology, 299 Campus Drive, Fairchild Science Building D231, Stanford, California 94305 5125, USA
    Nature 486:410-4. 2012
    ..This is achieved by increasing the surface level and clustering, but not overall cellular protein level, of the GluA1 subunit of the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) glutamate receptor (AMPAR)...
  76. pmc Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome
    Zhao hui Xu
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, China
    PLoS ONE 7:e48741. 2012
    ..Furthermore, 5-HT2AR inhibition induced AMPA receptor GluR1 subtype surface insertion in the cultured ACC neurons of Fmr1 WT mice, however, GluR1 surface insertion by ..
  77. pmc Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission
    Marc P Lussier
    Receptor Biology Section and Biochemistry Section Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:19426-31. 2012
    ..Therefore, our study identifies RNF167 as a selective regulator of AMPAR-mediated neurotransmission and expands our understanding of how ubiquitination dynamically regulates excitatory synapses...
  78. pmc Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea
    Lin Chien Huang
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neural Dev 7:38. 2012
    ..The OHC connections are then selectively eliminated, leaving sparse innervation by type II afferent fibres, whilst the type I afferent synapses with IHCs are consolidated...
  79. ncbi Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice
    Y Ryo
    Department of Molecular Neurobiology, University of Tokyo, Japan
    J Neurosci Res 36:19-32. 1993
    ..receptor type 1 alpha (mGluR1 alpha) and the non-N-methyl-D-aspartate (NMDA) ionotropic glutamate receptor type 1 (GluR1) in mouse brain was investigated using the antibodies raised against the synthetic peptides corresponding to their ..
  80. pmc Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM
    B D Holst
    Department of Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:2597-602. 1998
    ....
  81. ncbi Glutamate receptors: brain function and signal transduction
    S Nakanishi
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606, Japan
    Brain Res Brain Res Rev 26:230-5. 1998
    ..Thus, the two closely related mGluR subtypes mediate diverging intracellular signaling in glutamate transmission...
  82. pmc A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing
    P J Aruscavage
    Department of Biochemistry Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132, USA
    RNA 6:257-69. 2000
    ..The approximately 600-nt intron 13 of gluR-C was particularly remarkable, showing >94% nucleotide identity between human and chicken, organisms estimated to have diverged 310 million years ago...
  83. ncbi BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2
    Fernando Aguado
    Department of Cell Biology Faculty of Biology, and Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
    Development 130:1267-80. 2003
    ..Given that BDNF itself is regulated by neuronal activity, we suggest that BDNF acts as a homeostatic factor controlling the emergence, complexity and networking properties of spontaneous networks...
  84. pmc Cocaine-induced potentiation of synaptic strength in dopamine neurons: behavioral correlates in GluRA(-/-) mice
    Y Dong
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Proc Natl Acad Sci U S A 101:14282-7. 2004
    ..This enhancement requires the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluRA as evidenced by its absence in mice lacking this subunit...
  85. pmc Molecular constituents of neuronal AMPA receptors
    Yuko Fukata
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 169:399-404. 2005
    ..AMPARs: an immature complex with the endoplasmic reticulum chaperone immunoglobulin-binding protein and a mature complex containing GluR1, TARPs, and PSD-95. These studies establish TARPs as the auxiliary components of neuronal AMPARs.
  86. ncbi Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1
    Chong Hyun Kim
    Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Nat Neurosci 8:985-7. 2005
    The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation...
  87. ncbi Gene expression differences in mice divergently selected for methamphetamine sensitivity
    Abraham A Palmer
    Columbia Genome Center, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mamm Genome 16:291-305. 2005
    ..detected for several genes, including Casein Kinase 1 Epsilon (Csnkle), glutamate receptor, ionotropic, AMPA1 (GluR1), GABA B1 receptor (Gabbr1), and dopamine- and cAMP-regulated phosphoprotein of 32 kDa (Darpp-32). We used the www...
  88. ncbi Differential co-expression of AMPA receptor subunits in substance P receptor-containing neurons of basal forebrain regions of C57/BL mice
    Jin Ping Zhang
    Institute of Neurosciences, The Fourth Military Medical University, Shaanxi, Xi an 710032, PR China
    Neurochem Int 49:319-26. 2006
    ..co-expression patterns of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptor subunits 1-4 (GluR1-4) in substance P receptor (SPR)-containing neurons of the basal forebrain, which may act as a morphological basis ..
  89. ncbi Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matter
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:9184-95. 2006
    ..Our findings support a model of cerebellar neurogenesis, in which glutamatergic and GABAergic neurons are produced from separate progenitor pools located mainly in the rhombic lip and the cerebellar ventricular zone, respectively...
  90. ncbi Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors
    Zhiqiang Chen
    Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 10:1238-40. 2007
    ..Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body...
  91. ncbi Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity
    Khosrow Rezvani
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:10508-19. 2007
    ..The same nicotine treatment increased the levels of the AMPA glutamate receptor subunit GluR1, the NMDA receptor subunit NR2A, the metabotropic receptor mGluR1alpha, the plasticity factor Homer-1A, and the ..
  92. pmc Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity
    Pingwei Zhao
    Forbes Norris ALS MDA Research Center, California Pacific Medical Center Research Institute, 475 Brannan St, Suite 220, San Francisco, CA 94107, USA
    Eur J Neurosci 27:572-9. 2008
    ..the synaptic localization of specific subclasses of AMPARs [as determined by the presence of the subunits glutamate receptor 1 (GluR1) or glutamate receptor 2 (GluR2)] and CB1 in spinal cord motor neurons during disease progression in ..
  93. pmc GluR1 controls dendrite growth through its binding partner, SAP97
    Weiguo Zhou
    Department of Pediatrics, Division of Neurology, Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:10220-33. 2008
    ..In the present study, we examined the mechanism by which the GluR1 subunit of AMPA receptors controls dendrite morphogenesis...
  94. pmc Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits
    Romain H Fontaine
    Institut National de la Sante et de la Recherche Medicale, AVENIR RO5230HS, Paris, France
    Proc Natl Acad Sci U S A 105:16779-84. 2008
    ..Gestational hypoxia may regulate the expression of specific glutamate-receptor subunits in fetal mice but not in fetal rats. Therefore, genetic factors may influence the susceptibility of rodents to WMD...
  95. pmc Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating
    Anders S Kristensen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Neurosci 14:727-35. 2011
    ..Ca(2+)/calmodulin-dependent kinase II (CaMKII) phosphorylates the GluA1 AMPA receptor subunit at Ser831 to increase single-channel conductance...
  96. pmc High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies
    Marie Lise Quille
    INSERM U613, Brest, France
    PLoS ONE 6:e25181. 2011
    ..Overall, these results identified multiple new candidate targets for Arx and should help to better understand the pathophysiological mechanisms of intellectual disability and epilepsy associated with ARX mutations...
  97. ncbi The TiPS/TINS lecture: the molecular biology of mammalian glutamate receptor channels
    P H Seeburg
    University of Heidelberg, Centre of Molecular Biology ZMBH, Germany
    Trends Pharmacol Sci 14:297-303. 1993
    ..This review describes the different channel types obtained by recombinant means and the genetic mechanisms controlling the expression of functionally important channel structures...
  98. ncbi AMPA receptor subunits expressed by single astrocytes in the juvenile mouse hippocampus
    G Seifert
    Institute of Physiology, Department of Neurophysiology, Friedrich Schiller University Jena, Germany
    Brain Res Mol Brain Res 47:286-94. 1997
    ..The glial receptors might be involved in the modulation of gene expression as well as the regulation of proliferation and differentiation...
  99. ncbi Cloning of novel splice variants of mouse mGluR1
    H Zhu
    Laboratory for Cancer Research, Chemical Biology Department, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA
    Brain Res Mol Brain Res 73:93-103. 1999
    Three splice variants of the mouse metabotropic glutamate receptor 1, mGluR1E55, mGluR1a and mGluR1b, have been isolated from mouse brain cDNA libraries. The sequences of mGluR1a and mGluR1b are similar to those from rat and human...
  100. ncbi mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination
    T Ichise
    Laboratory of DNA Biology and Embryo Engineering, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Science 288:1832-5. 2000
    ..The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum...
  101. ncbi Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors
    T Maejima
    Department of Physiology, Kanazawa University School of Medicine, Takara machi, Kanazawa 920 8640, Japan
    Neuron 31:463-75. 2001
    ..Our data highlight a signaling mechanism whereby activation of postsynaptic mGluR retrogradely influences presynaptic functions via endocannabinoid system...

Research Grants7

  1. ACTIVITY DEPENDENT MECHANISMS OF VISUAL DEVELOPMENT
    Mriganka Sur; Fiscal Year: 2002
    ..Such approaches are crucial to understanding the complex cellular mechanisms that underlie the development and refinement of connections during pattern formation. ..
  2. DYNAMIC INTEGRATION IN SOMATOSENSORY CORTEX
    Mriganka Sur; Fiscal Year: 2004
    ..Information from these experiments will be important for understanding the integration of multiple inputs in sensory cortex, and more generally for understanding cortical mechanisrns of object detection and discrimination. ..
  3. Novel genes underlying connectivity in the visual cortex
    Mriganka Sur; Fiscal Year: 2005
    ..abstract_text> ..
  4. Cortical Plasticity: Inputs, Networks and Behavior
    Mriganka Sur; Fiscal Year: 2007
    ..abstract_text> ..
  5. Structural correlates of rapid cortical plasticity
    Mriganka Sur; Fiscal Year: 2010
    ..Such information is critical for explaining pathologies of cortical development, and for suggesting strategies for treatment. ..
  6. Molecular and functional mechanisms underlying binocular vision
    Mriganka Sur; Fiscal Year: 2010
    ..The planned experiments promise to elucidate the mechanisms by which Ten_m3 expression affects the development of binocular vision, and thus to provide a novel basis for the design of therapies for visual dysfunction. ..
  7. Nitric Oxide Regulation of Platelet Granule Exocytosis
    CRAIG MORRELL; Fiscal Year: 2008
    ..Therefore, strategies to minimize granule exocytosis may prove valuable in the acute treatment of pro-thrombotic diseases. (End of Abstract) [unreadable] [unreadable]..