GR-1

Summary

Gene Symbol: GR-1
Description: glutathione reductase
Alias: AI325518, D8Ertd238e, Gr-1, Gr1, glutathione reductase, mitochondrial, GRase, glutathione reductase 1
Species: mouse

Top Publications

  1. pmc Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver
    Sofi Eriksson
    1 Department of Microbiology and Immunology, Montana State University, Cooley Hall, PO Box 173520, Bozeman, Montana 59717, USA 2 Division of Biochemistry, Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nat Commun 6:6479. 2015
  2. pmc Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization
    Erin J Plosa
    Department of Pediatrics, Division of Neonatology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 141:4751-62. 2014
  3. ncbi Glucose-6-phosphate isomerase deficiency associated with nonspherocytic hemolytic anemia in the mouse: an animal model for the human disease
    S Merkle
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Saugetiergenetik, Neuherberg, Germany
    Blood 81:206-13. 1993
  4. pmc Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps
    Jing Yan
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA
    J Immunol 188:2316-27. 2012
  5. ncbi Genetic mapping of the amphotropic murine leukemia virus receptor on mouse chromosome 8
    M S Lyu
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Virology 204:868-9. 1994
  6. ncbi Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains
    R Lange
    Institut fur Genetik, Universitat zu Koln, Germany
    DNA Cell Biol 14:971-81. 1995
  7. ncbi Gene structure for mouse glutathione reductase, including a putative mitochondrial targeting signal
    T Tamura
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, 77030, USA
    Biochem Biophys Res Commun 237:419-22. 1997
  8. ncbi Glutathione reductase activity deficiency in homozygous Gr1a1Neu mice does not cause haemolytic anaemia
    W Pretsch
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Genet Res 73:1-5. 1999
  9. ncbi Assembly and functional expression of murine glutathione reductase cDNA: a sequence missing in expressed sequence tag libraries
    R Iozef
    Center of Biochemistry, Heidelberg University, Im Neuenheimer Feld 328, D 69120, Heidelberg, Germany
    Biochim Biophys Acta 1500:137-41. 2000
  10. ncbi Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints
    E P Blankenhorn
    Department of Microbiology and Immunology, MCP Hahnemann University, Philadelphia, PA 19129, USA
    J Immunol 164:3420-5. 2000

Scientific Experts

  • Ingrid G Winkler
  • L K Rogers
  • Elizabeth P Blankenhorn
  • Walter Pretsch
  • Alison C Brewer
  • Trent E Tipple
  • Samina Salim
  • Sofi Eriksson
  • Erin J Plosa
  • Jing Yan
  • Mu Qiao
  • Iiris Hovatta
  • Justin R Prigge
  • Elias S J Arner
  • Emily A Talago
  • Edward E Schmidt
  • Vasiliy V Polosukhin
  • Rinat Zaynagetdinov
  • Peter M Gulleman
  • Riet Van Der Meer
  • John T Benjamin
  • Wei Han
  • Lawrence S Prince
  • Roy Zent
  • Timothy S Blackwell
  • Lisa R Young
  • Linda A Gleaves
  • Amanda M Im
  • Nada Bulus
  • Leif D Nelin
  • Xiaomei Meng
  • Bernadette Chen
  • Yusen Liu
  • Kevin P Francis
  • Lyn M Wancket
  • Katherine Lintner
  • Charles V Smith
  • R Iozef
  • Melanie S Sulistio
  • Reto Asmis
  • Eric J Smart
  • Marta Kisgati
  • Jill M Cholewa
  • Weifei Zhu
  • Robert Helton
  • Jeffrey M Redwine
  • Richard S Tennant
  • Julie A Ellison
  • Oded Singer
  • Eric E Schadt
  • Robert A Marr
  • Carrolee Barlow
  • Inder M Verma
  • David J Lockhart
  • T Tamura
  • R H Schirmer
  • C A Kozak
  • D Werner
  • R Lange
  • C C Boehme
  • K Becker
  • M S Lyu
  • T N Hansen
  • H W McMicken
  • C V Smith
  • S Merkle
  • M Plomann
  • K R Johnson
  • G Vopper
  • A Christoph
  • L Lemaire
  • H J Thiesen
  • D Barthels
  • U A Heinlein
  • H Cremer
  • F H Ruddle
  • R L Stallings
  • P A Lalley
  • O W McBride
  • S J O'Brien
  • C L MacLeod
  • J H Nadeau
  • C S Birkenmeier
  • M Danciger
  • G Muller
  • E A Nichols
  • C Kozak
  • T G Kirchgessner
  • U Francke
  • M Tutic

Detail Information

Publications35

  1. pmc Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver
    Sofi Eriksson
    1 Department of Microbiology and Immunology, Montana State University, Cooley Hall, PO Box 173520, Bozeman, Montana 59717, USA 2 Division of Biochemistry, Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nat Commun 6:6479. 2015
    ..Although NADPH is generally considered an essential reducing currency, these results indicate that hepatocytes can adequately sustain cytosolic redox homeostasis pathways using either NADPH or methionine. ..
  2. pmc Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization
    Erin J Plosa
    Department of Pediatrics, Division of Neonatology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 141:4751-62. 2014
    ....
  3. ncbi Glucose-6-phosphate isomerase deficiency associated with nonspherocytic hemolytic anemia in the mouse: an animal model for the human disease
    S Merkle
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Saugetiergenetik, Neuherberg, Germany
    Blood 81:206-13. 1993
    ....
  4. pmc Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps
    Jing Yan
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA
    J Immunol 188:2316-27. 2012
    ..Thus, Gsr-mediated redox regulation is crucial for bacterial clearance during host defense against massive bacterial challenge...
  5. ncbi Genetic mapping of the amphotropic murine leukemia virus receptor on mouse chromosome 8
    M S Lyu
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Virology 204:868-9. 1994
    ..Analysis of the progeny of two interspecies genetic crosses was used to establish the genetic map location of the mouse gene encoding this receptor, Ram1, within the proximal region of chromosome 8...
  6. ncbi Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains
    R Lange
    Institut fur Genetik, Universitat zu Koln, Germany
    DNA Cell Biol 14:971-81. 1995
    ..The NK10 KRAB domains exhibit repressing activity when tested in GAL4 fusion protein assays. Cloning of putative target sequences revealed that the individual domains differentially contribute to zinc-dependent target DNA binding...
  7. ncbi Gene structure for mouse glutathione reductase, including a putative mitochondrial targeting signal
    T Tamura
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, 77030, USA
    Biochem Biophys Res Commun 237:419-22. 1997
    ..The data indicate that this 78 bp sequence encodes a potential MTS for GR in mice...
  8. ncbi Glutathione reductase activity deficiency in homozygous Gr1a1Neu mice does not cause haemolytic anaemia
    W Pretsch
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Genet Res 73:1-5. 1999
    ..Results of linkage studies indicate a mutation at the Gr1 structural locus on chromosome 8. The loss of GR activity was evident both in blood and in other tissue extracts...
  9. ncbi Assembly and functional expression of murine glutathione reductase cDNA: a sequence missing in expressed sequence tag libraries
    R Iozef
    Center of Biochemistry, Heidelberg University, Im Neuenheimer Feld 328, D 69120, Heidelberg, Germany
    Biochim Biophys Acta 1500:137-41. 2000
    ..Another cDNA, representing GR with a mitochondrial targeting sequence, yielded two distinct enzymically active expression products...
  10. ncbi Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints
    E P Blankenhorn
    Department of Microbiology and Immunology, MCP Hahnemann University, Philadelphia, PA 19129, USA
    J Immunol 164:3420-5. 2000
    ..Taken together, these results suggest that eae9 controls the effects of PTX in EAE susceptibility, and is capable of overriding the other genetic checkpoints in the pathogenesis of this disease...
  11. ncbi Analyses of glutathione reductase hypomorphic mice indicate a genetic knockout
    Lynette K Rogers
    Center for Developmental Pharmacology and Toxicology, Children s Research Institute, Columbus, Ohio 43205, USA
    Toxicol Sci 82:367-73. 2004
    ..The Neu mice offer live animal models with which to test hypotheses regarding oxidant mechanisms of tissue injury in vivo...
  12. pmc Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 201:1077-88. 2005
    ..These data suggest an unexpected role for serpina1 and serpina3 in regulating the bone marrow hematopoietic microenvironment as well as influencing the migratory behavior of hematopoietic precursors...
  13. ncbi Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice
    Iiris Hovatta
    The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 438:662-6. 2005
    ..To determine if two of the genes, glyoxalase 1 and glutathione reductase 1, have a causal role in the genesis of anxiety, we performed genetic manipulation using lentivirus-..
  14. ncbi Diquat induces renal proximal tubule injury in glutathione reductase-deficient mice
    Lynette K Rogers
    Center for Developmental Pharmacology and Toxicology, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Toxicol Appl Pharmacol 217:289-98. 2006
    ..To test the hypothesis that Gr1(a1Neu) (Neu) mice, which do not express glutathione reductase (GR), would be more susceptible than are wild-type ..
  15. ncbi Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice
    Mu Qiao
    Division of Nephrology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Arterioscler Thromb Vasc Biol 27:1375-82. 2007
    ..We investigated if strengthening the glutathione-dependent antioxidant system in macrophages by overexpressing glutathione reductase (GR) decreases the severity of atherosclerosis...
  16. pmc Thioredoxin-related mechanisms in hyperoxic lung injury in mice
    Trent E Tipple
    Columbus Children s Research Institute, Columbus Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Am J Respir Cell Mol Biol 37:405-13. 2007
    ..The protective effects of ATG against hyperoxic lung injury could prove to be particularly useful therapeutically...
  17. pmc Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells
    Samina Salim
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas, USA
    FEBS Lett 585:1375-81. 2011
    ..Our study is the first to suggest role of RGS2 in regulation of enzymes involved in antioxidant defense namely glyoxalase-1 and glutathione reductase-1 via activation of p38 MAPK and PKC pathways in an Sp-1 dependent manner...
  18. pmc Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo
    Alison C Brewer
    King s College London British Heart Foundation Centre of Research Excellence, Cardiovascular Division, London, UK
    Free Radic Biol Med 51:205-15. 2011
    ..These data therefore demonstrate that Nox4 can activate the Nrf2-regulated pathway, and suggest a potential role for Nox4 in the regulation of GSH redox in cardiomyocytes...
  19. ncbi Cloning and sequencing of mammalian glutathione reductase cDNA
    M Tutic
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    Eur J Biochem 188:523-8. 1990
    ..The amino acid sequence deduced from the nucleotide sequences of the three subclones is identical with the known sequence of the mature glutathione reductase from human erythrocytes in all 478 positions...
  20. ncbi Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids
    C A Kozak
    Somatic Cell Genet 3:121-33. 1977
  21. ncbi Activity and electrophoretic mobility of glutathione reductase allozymes in different tissues of the mouse
    S Firth
    Biochem Genet 17:229-32. 1979
  22. ncbi Polymorphism and linkage of glutathione reductase in Mus musculus
    E A Nichols
    Biochem Genet 13:323-9. 1975
    ..Using an electrophoretic variant for glutathione reductase, we have been able to map the structural gene for this enzyme to chromosome 8 in Mus musculus...
  23. ncbi Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome
    C Kozak
    Somatic Cell Genet 1:371-82. 1975
    ..All other isozymes examined segregated independently of one another...
  24. pmc Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor
    C L MacLeod
    Department of Medicine, University of California, San Diego, La Jolla 92093
    Mol Cell Biol 10:3663-74. 1990
    ..Neither gene product displayed significant homology with other known transmembrane-spanning proteins. Thus, the Tea and Rec-1 genes establish a new family encoding multiple membrane-spanning proteins...
  25. ncbi Mapping of the gene for DNA polymerase beta to mouse chromosome 8
    O W McBride
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Cytogenet Cell Genet 53:108-11. 1990
    ..These results provide additional support for the regional localization of polymerase beta on the short arm of human chromosome 8 or the very proximal end of the long arm...
  26. ncbi Zinc finger protein gene complexes on mouse chromosomes 8 and 11
    J H Nadeau
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 8:469-76. 1990
    ..Surprisingly, both genes were closely linked to two previously mapped, Krüppel-related zinc finger protein genes, suggesting that they are part of gene complexes...
  27. pmc Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin
    R A White
    Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 87:3117-21. 1990
    ..The linkage data suggest that the mouse and human diseases result from mutations in homologous loci...
  28. ncbi Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2
    U Francke
    Cytogenet Cell Genet 19:57-84. 1977
    ..Striking examples of norandom segregation of mouse chromosomes were observed in these hybrids with preferential retention of 15 and segregation of 11 and the Y chromosome...
  29. ncbi The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8
    M Danciger
    Jules Stein Eye Institute, UCLA School of Medicine 90024 1771
    Genomics 6:428-35. 1990
    ..The other sequence was on chromosome 8 and is either a pseudogene or an as yet undiscovered third G beta-subunit gene, here termed Gnb-3...
  30. ncbi Isolation, characterization and chromosomal mapping of the mouse tyrosine aminotransferase gene
    G Muller
    J Mol Biol 184:367-73. 1985
    ..Since the albino deletions are located on mouse chromosome 7, the assignment of the TAT gene to chromosome 8 suggests that a regulatory factor(s) affecting TAT gene expression acts in trans...
  31. ncbi Genetic and developmental regulation of the lipoprotein lipase gene: loci both distal and proximal to the lipoprotein lipase structural gene control enzyme expression
    T G Kirchgessner
    Department of Medicine, University of California, Los Angeles 90024
    J Biol Chem 264:1473-82. 1989
    ..This indicates that combined deficiencies of LPL and hepatic lipase, observed in humans as well as in certain mutant strains of mice, do not result from focal disruptions of a cluster of lipase genes...
  32. pmc Genetic mapping of ecotropic murine leukemia virus-inducing loci in six inbred strains
    C A Kozak
    J Exp Med 155:524-34. 1982
    ..These studies provide further evidence that endogenous ecotropic V loci are present at different chromosomal sites in unrelated mouse strains and emphasize the role of germ line reinfections in the generation of this diversity...
  33. ncbi The metallothionein-I gene maps to mouse chromosome 8: implications for human Menkes' disease
    D R Cox
    Hum Genet 64:61-4. 1983
    ....
  34. ncbi Genetic mapping in mammals: chromosome map of domestic cat
    S J O'Brien
    Science 216:257-65. 1982
    ..Many of these same linkage groups have not been conserved in the murine genome. The genetic and evolutionary implications of comparative mapping analysis among mammalian species are discussed...
  35. ncbi Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7
    R L Stallings
    Somatic Cell Genet 7:683-98. 1981
    ..The assignments provide markers for the study of the genetic consequences of chromosomal rearrangements in Chinese hamster cell lines and support the concept of conservation of mammalian autosomal linkage groups...