Gpr88

Summary

Gene Symbol: Gpr88
Description: G-protein coupled receptor 88
Alias: AW061286, Strg, striatum-specific G-protein coupled receptor
Species: mouse

Top Publications

  1. doi The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?
    Sheree F Logue
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Mol Cell Neurosci 42:438-47. 2009
  2. doi Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice
    K Zhang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Neuroscience 275:238-47. 2014
  3. pmc Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice
    Alipi V Naydenov
    Medical Scientist Training Program, University of Washington, Seattle, WA USA Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA USA
    Neurobiol Dis 71:140-50. 2014
  4. doi Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice
    K Zhang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neuroscience 303:586-94. 2015
  5. pmc Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist
    Aura C Meirsman
    Département de Médecine Translationnelle et Neurogénétique, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U 964, National de la Recherche Scientifique UMR 7104, Universite de Strasbourg, Illkirch, France
    Biol Psychiatry 79:917-27. 2016
  6. pmc GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors
    Aura Carole Meirsman
    Département de Médecine Translationnelle et Neurogénétique, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U 964, CNRS UMR 7104, Universite de Strasbourg, 67400 Illkirch Graffenstaden, France
    Eneuro 3:. 2016
  7. pmc Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
    Albert Quintana
    Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, Washington, USA
    Nat Neurosci 15:1547-55. 2012
  8. ncbi A novel G-protein-coupled receptor gene expressed in striatum
    K Mizushima
    Division of Genome Biology, Cancer Research Institute, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 0934, Japan
    Genomics 69:314-21. 2000
  9. pmc Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization
    Lisa R Beutler
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:4206-11. 2011
  10. pmc The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning
    Jones G Parker
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 31:11362-9. 2011

Scientific Experts

  • Sheree F Logue
  • K Zhang
  • Richard D Palmiter
  • Albert Quintana
  • Lisa R Beutler
  • Aura Carole Meirsman
  • Aura C Meirsman
  • J J Soghomonian
  • Alipi V Naydenov
  • Nigel S Bamford
  • Elisenda Sanz
  • MATTHEW J WANAT
  • Jones G Parker
  • Brigitte Lina Kieffer
  • Julie Le Merrer
  • Jorge Diaz
  • Alban de Kerchove d'Exaerde
  • Lucie P Pellissier
  • Anne Robe
  • Daniel Clesse
  • Jerome A J Becker
  • Brigitte L Kieffer
  • C Chammas
  • Katie Swinney
  • K Hill
  • Nephi Stella
  • Lynn A Raymond
  • G J Blatt
  • Marja D Sepers
  • S Labak
  • Ali D Guler
  • Paul S Amieux
  • Granville P Storey
  • Bryan A Roller
  • Anna La Torre
  • G Stanley McKnight
  • Wengang Wang
  • Larry S Zweifel
  • K Mizushima
  • Y Sakaki
  • M Hirai
  • F Tsukahara
  • Y Miyamoto
  • T Ito

Detail Information

Publications10

  1. doi The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?
    Sheree F Logue
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Mol Cell Neurosci 42:438-47. 2009
    In rodents, the orphan G protein-coupled receptor, Gpr88, is highly expressed in brain regions implicated in the pathophysiology of and is modulated by treatments for schizophrenia...
  2. doi Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice
    K Zhang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Neuroscience 275:238-47. 2014
    ..in mice lacking the GABA-synthesizing enzyme glutamic acid decarboxylase, Gad67, in neurons expressing the protein Gpr88, an orphan G-protein-coupled receptor primarily expressed in the striatum...
  3. pmc Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice
    Alipi V Naydenov
    Medical Scientist Training Program, University of Washington, Seattle, WA USA Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA USA
    Neurobiol Dis 71:140-50. 2014
    ..We conclude that loss of excitatory striatal synapses in HD mice is controlled by CB1(MSN) and can be uncoupled from the motor phenotype. ..
  4. doi Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice
    K Zhang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neuroscience 303:586-94. 2015
    ..is densely expressed in striatal direct pathway striatal neurons while the orphan G-protein-coupled receptor Gpr88 is densely expressed in striatal direct and indirect pathway striatal neurons, we used a cre-lox strategy to ..
  5. pmc Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist
    Aura C Meirsman
    Département de Médecine Translationnelle et Neurogénétique, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U 964, National de la Recherche Scientifique UMR 7104, Universite de Strasbourg, Illkirch, France
    Biol Psychiatry 79:917-27. 2016
    b>GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in striatal physiology...
  6. pmc GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors
    Aura Carole Meirsman
    Département de Médecine Translationnelle et Neurogénétique, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U 964, CNRS UMR 7104, Universite de Strasbourg, 67400 Illkirch Graffenstaden, France
    Eneuro 3:. 2016
    b>GPR88 is an orphan G-protein-coupled receptor highly expressed in striatal dopamine D1 (receptor) R- and D2R-expressing medium spiny neurons...
  7. pmc Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
    Albert Quintana
    Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, Washington, USA
    Nat Neurosci 15:1547-55. 2012
    ..The orphan G protein-coupled receptor GPR88 is robustly expressed in MSNs and is regulated by neuropharmacological drugs, but its contribution to MSN ..
  8. ncbi A novel G-protein-coupled receptor gene expressed in striatum
    K Mizushima
    Division of Genome Biology, Cancer Research Institute, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 0934, Japan
    Genomics 69:314-21. 2000
    ..revealed a novel striatum-specific transcript encoding an orphan G-protein-coupled receptor (GPCR) designated Strg/Gpr88 for striatum-specific GPCR...
  9. pmc Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization
    Lisa R Beutler
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:4206-11. 2011
    ....
  10. pmc The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning
    Jones G Parker
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 31:11362-9. 2011
    ..Our findings suggest that NMDARs in neurons that project to and receive projections from the VTA are necessary for Pavlovian conditioning and specifically implicate the PFC and D(1)R-expressing MSNs in associative learning...