Gene Symbol: Gpr88
Description: G-protein coupled receptor 88
Alias: AW061286, Strg, striatum-specific G-protein coupled receptor
- The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?Sheree F Logue
Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
Mol Cell Neurosci 42:438-47. 2009In rodents, the orphan G protein-coupled receptor, Gpr88, is highly expressed in brain regions implicated in the pathophysiology of and is modulated by treatments for schizophrenia...
- Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in miceK Zhang
Department of Anatomy and Neurobiology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
Neuroscience 275:238-47. 2014..in mice lacking the GABA-synthesizing enzyme glutamic acid decarboxylase, Gad67, in neurons expressing the protein Gpr88, an orphan G-protein-coupled receptor primarily expressed in the striatum...
- Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD miceAlipi V Naydenov
Medical Scientist Training Program, University of Washington, Seattle, WA USA Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA USA
Neurobiol Dis 71:140-50. 2014..We conclude that loss of excitatory striatal synapses in HD mice is controlled by CB1(MSN) and can be uncoupled from the motor phenotype. ..
- Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned miceK Zhang
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
Neuroscience 303:586-94. 2015..is densely expressed in striatal direct pathway striatal neurons while the orphan G-protein-coupled receptor Gpr88 is densely expressed in striatal direct and indirect pathway striatal neurons, we used a cre-lox strategy to ..
- Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid AntagonistAura C Meirsman
Département de Médecine Translationnelle et Neurogénétique, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U 964, National de la Recherche Scientifique UMR 7104, Universite de Strasbourg, Illkirch, France
Biol Psychiatry 79:917-27. 2016b>GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in striatal physiology...
- GPR88 in A2AR Neurons Enhances Anxiety-Like BehaviorsAura Carole Meirsman
Département de Médecine Translationnelle et Neurogénétique, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U 964, CNRS UMR 7104, Universite de Strasbourg, 67400 Illkirch Graffenstaden, France
Eneuro 3:. 2016b>GPR88 is an orphan G-protein-coupled receptor highly expressed in striatal dopamine D1 (receptor) R- and D2R-expressing medium spiny neurons...
- Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviorsAlbert Quintana
Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, Washington, USA
Nat Neurosci 15:1547-55. 2012..The orphan G protein-coupled receptor GPR88 is robustly expressed in MSNs and is regulated by neuropharmacological drugs, but its contribution to MSN ..
- A novel G-protein-coupled receptor gene expressed in striatumK Mizushima
Division of Genome Biology, Cancer Research Institute, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 0934, Japan
Genomics 69:314-21. 2000..revealed a novel striatum-specific transcript encoding an orphan G-protein-coupled receptor (GPCR) designated Strg/Gpr88 for striatum-specific GPCR...
- Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitizationLisa R Beutler
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 108:4206-11. 2011....
- The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learningJones G Parker
Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
J Neurosci 31:11362-9. 2011..Our findings suggest that NMDARs in neurons that project to and receive projections from the VTA are necessary for Pavlovian conditioning and specifically implicate the PFC and D(1)R-expressing MSNs in associative learning...