Gpr50

Summary

Gene Symbol: Gpr50
Description: G-protein-coupled receptor 50
Alias: melatonin-related receptor
Species: mouse

Top Publications

  1. ncbi Photoperiodic regulation of cellular retinol binding protein, CRBP1 [corrected] and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster
    Perry Barrett
    Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity ACERO, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    J Endocrinol 191:687-98. 2006
  2. ncbi Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse
    Elena A Ivanova
    Faculty of Life Sciences, Univ of Manchester, 1 124 Stopford Bldg, Oxford Road, Manchester, UK, M13 9PT
    Am J Physiol Endocrinol Metab 294:E176-82. 2008
  3. doi GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth
    Ellen Grünewald
    Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH42XU, UK
    Mol Cell Neurosci 42:363-71. 2009
  4. doi A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor
    David A Bechtold
    University of Manchester, Manchester M13 9PT, UK
    Curr Biol 22:70-7. 2012
  5. pmc The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation
    Juan Salvatierra
    Department of Neuroscience
    J Neurosci 34:16809-20. 2014
  6. doi G protein coupled receptor 50 promotes self-renewal and neuronal differentiation of embryonic neural progenitor cells through regulation of notch and wnt/β-catenin signalings
    Yan xia Ma
    Jiangsu Key Laboratory of Translational Research and Therapy for Neuro Psycho Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu Province 215021, China
    Biochem Biophys Res Commun 458:836-42. 2015
  7. doi Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains
    M Batailler
    INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
    J Neuroendocrinol 24:798-808. 2012
  8. pmc Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain
    Ellen Grünewald
    Medical Genetics Section, University of Edinburgh, Institute of Genetics and Molecular Medicine, Molecular Medicine Centre, Crewe Road, Edinburgh EH2 4XU, United Kingdom
    ACS Chem Neurosci 3:459-72. 2012
  9. pmc Increased bone mass in mice lacking the adipokine apelin
    Lalita Wattanachanya
    Veterans Affairs Medical Center 111 N, 4150 Clement Street, San Francisco, California 94121, USA
    Endocrinology 154:2069-80. 2013
  10. pmc Induction of the metabolic regulator Txnip in fasting-induced and natural torpor
    Laura E Hand
    Faculty of Life Sciences, AV Hill Building, University of Manchester, Manchester M13 9PT, UK
    Endocrinology 154:2081-91. 2013

Scientific Experts

  • Ellen Grünewald
  • David A Bechtold
  • Perry Barrett
  • Laura E Hand
  • Andrew S I Loudon
  • Yan xia Ma
  • Juan Salvatierra
  • Lalita Wattanachanya
  • M Batailler
  • Jian Li
  • Charles J Billington
  • Anissa Sidibe
  • Weiguo Feng
  • Elena A Ivanova
  • Zhi Qiang Wu
  • Quan Hong Ma
  • Xiao ling Qin
  • Zhi Cheng Xiao
  • Yong Jie Feng
  • Jose Manuel Garcia-Verdugo
  • Joseph L Bedont
  • Elizabeth A Newman
  • Sara Gil-Perotin
  • María Duran-Moreno
  • Ana L Miranda-Angulo
  • Hong Wang
  • Sooyeon Yoo
  • Cristina Zibetti
  • Seth Blackshaw
  • Daniel A Lee
  • Jimmy de Melo
  • Ben R C Saer
  • Stephan Steinlechner
  • Wei Dar Lu
  • Robert A Nissenson
  • Marcia J Abbott
  • Liping Wang
  • Hyder A Jinnah
  • Dylan O'Carroll
  • Simon T Hui
  • Ramendra K Kundu
  • Thomas Quertermous
  • A Sidibe
  • P Delagrange
  • V Prevot
  • A Mullier
  • R Jockers
  • M Migaud
  • Gunnar Schotta
  • Brian Schmidt
  • Qing Jun Meng
  • Brandon Ng
  • Rajaram Gopalakrishnan
  • David E Symer
  • Cynthia Forsman
  • Anna Petryk
  • Aaron L Sarver
  • Anindya Bagchi
  • Vincent Prevot
  • Ralf Jockers
  • Amandine Mullier
  • Jean A Boutin
  • Patty Chen
  • Marc Baroncini
  • Philippe Delagrange
  • Hannah Tipney
  • Tzulip Phang
  • Sonia M Leach
  • Mark Geraci
  • Richard A Spritz
  • Trevor Williams
  • LAWRENCE E HUNTER
  • Simon M Luckman
  • A K Gubitz
  • Sandrine M Dupré
  • John Brennand
  • S M Reppert

Detail Information

Publications15

  1. ncbi Photoperiodic regulation of cellular retinol binding protein, CRBP1 [corrected] and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster
    Perry Barrett
    Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity ACERO, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    J Endocrinol 191:687-98. 2006
    ..We demonstrate that cellular retinol binding protein [corrected] (CRBP1), a retinoic acid transport protein, GPR50, an orphan G-protein-coupled receptor and nestin, an intermediate filament protein, are down-regulated in short-..
  2. ncbi Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse
    Elena A Ivanova
    Faculty of Life Sciences, Univ of Manchester, 1 124 Stopford Bldg, Oxford Road, Manchester, UK, M13 9PT
    Am J Physiol Endocrinol Metab 294:E176-82. 2008
    The X-linked orphan receptor GPR50 shares 45% homology with the melatonin receptors, yet its ligand and physiological function remain unknown...
  3. doi GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth
    Ellen Grünewald
    Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH42XU, UK
    Mol Cell Neurosci 42:363-71. 2009
    ..We sought to understand the function of one such orphan, G protein-coupled receptor 50 (GPR50), through identification of protein interactors...
  4. doi A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor
    David A Bechtold
    University of Manchester, Manchester M13 9PT, UK
    Curr Biol 22:70-7. 2012
    ..We show that the orphan receptor GPR50 plays an important role in adaptive thermogenesis and torpor...
  5. pmc The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation
    Juan Salvatierra
    Department of Neuroscience
    J Neurosci 34:16809-20. 2014
    ..These findings provide key insights into the transcriptional regulatory network specifying this still poorly characterized cell type...
  6. doi G protein coupled receptor 50 promotes self-renewal and neuronal differentiation of embryonic neural progenitor cells through regulation of notch and wnt/β-catenin signalings
    Yan xia Ma
    Jiangsu Key Laboratory of Translational Research and Therapy for Neuro Psycho Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu Province 215021, China
    Biochem Biophys Res Commun 458:836-42. 2015
    G protein-coupled receptor 50 (GPR50), a risk factor for major depressive disorder and bipolar affective disorder, is expressed in both the developmental and adult brain. However, the function of GPR50 in the brain remains unknown...
  7. doi Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains
    M Batailler
    INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
    J Neuroendocrinol 24:798-808. 2012
    b>GPR50, formerly known as melatonin-related receptor, is one of three subtypes of the melatonin receptor subfamily, together with the MT(1) and MT(2) receptors...
  8. pmc Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain
    Ellen Grünewald
    Medical Genetics Section, University of Edinburgh, Institute of Genetics and Molecular Medicine, Molecular Medicine Centre, Crewe Road, Edinburgh EH2 4XU, United Kingdom
    ACS Chem Neurosci 3:459-72. 2012
    ..Orphan G protein-coupled receptor 50 (GPR50) has been identified as a genetic risk factor for bipolar disorder and major depression in women, and there is ..
  9. pmc Increased bone mass in mice lacking the adipokine apelin
    Lalita Wattanachanya
    Veterans Affairs Medical Center 111 N, 4150 Clement Street, San Francisco, California 94121, USA
    Endocrinology 154:2069-80. 2013
    ..These results indicate that apelin functions as a physiologically significant antianabolic factor in bone in vivo...
  10. pmc Induction of the metabolic regulator Txnip in fasting-induced and natural torpor
    Laura E Hand
    Faculty of Life Sciences, AV Hill Building, University of Manchester, Manchester M13 9PT, UK
    Endocrinology 154:2081-91. 2013
    ..We recently showed that mice lacking the orphan G protein-coupled receptor Gpr50 readily enter torpor in response to fasting and have now used these mice to conduct a microarray analysis of ..
  11. ncbi Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)
    A K Gubitz
    Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA
    Genomics 55:248-51. 1999
    ..Both genes were found to be X-linked: radiation hybrid mapping revealed that the human H9 gene (GPR50) is localized to Xq28...
  12. pmc Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences
    Weiguo Feng
    Department of Craniofacial Biology, University of Colorado Denver, Aurora, Colorado, USA
    PLoS ONE 4:e8066. 2009
    ..Overall, our studies provide a valuable resource for probing orofacial development and a robust dataset for bioinformatic analysis of spatial and temporal gene expression changes during embryogenesis...
  13. doi Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence
    Anissa Sidibe
    Institut Cochin, Universite Paris Descartes, CNRS, France
    J Pineal Res 48:263-9. 2010
    ..is composed of three members, MT(1) and MT(2) receptors that bind melatonin with high affinity and the orphan GPR50 that does not bind melatonin but shares significant sequence homology with the two other subtypes...
  14. pmc The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice
    Charles J Billington
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455 0356, USA
    Dev Biol 355:21-31. 2011
    ..We postulate that variable responses to stress may contribute to variable craniofacial phenotypes by triggering differential expression of genes and variable cellular apoptosis...
  15. pmc GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling
    Jian Li
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    PLoS ONE 6:e23725. 2011
    b>GPR50 is an orphan G-protein coupled receptor most closely related to the melatonin receptors. The physiological function of GPR50 remains unclear, although our previous studies implicate the receptor in energy homeostasis...