Gene Symbol: Gpr50
Description: G-protein-coupled receptor 50
Alias: melatonin-related receptor
- Photoperiodic regulation of cellular retinol binding protein, CRBP1 [corrected] and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamsterPerry Barrett
Molecular Endocrinology Group, Division of Obesity and Metabolic Health and Aberdeen Centre for Energy Regulation and Obesity ACERO, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
J Endocrinol 191:687-98. 2006..We demonstrate that cellular retinol binding protein [corrected] (CRBP1), a retinoic acid transport protein, GPR50, an orphan G-protein-coupled receptor and nestin, an intermediate filament protein, are down-regulated in short-..
- Altered metabolism in the melatonin-related receptor (GPR50) knockout mouseElena A Ivanova
Faculty of Life Sciences, Univ of Manchester, 1 124 Stopford Bldg, Oxford Road, Manchester, UK, M13 9PT
Am J Physiol Endocrinol Metab 294:E176-82. 2008The X-linked orphan receptor GPR50 shares 45% homology with the melatonin receptors, yet its ligand and physiological function remain unknown...
- GPR50 interacts with neuronal NOGO-A and affects neurite outgrowthEllen Grünewald
Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH42XU, UK
Mol Cell Neurosci 42:363-71. 2009..We sought to understand the function of one such orphan, G protein-coupled receptor 50 (GPR50), through identification of protein interactors...
- A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torporDavid A Bechtold
University of Manchester, Manchester M13 9PT, UK
Curr Biol 22:70-7. 2012..We show that the orphan receptor GPR50 plays an important role in adaptive thermogenesis and torpor...
- The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiationJuan Salvatierra
Department of Neuroscience
J Neurosci 34:16809-20. 2014..These findings provide key insights into the transcriptional regulatory network specifying this still poorly characterized cell type...
- G protein coupled receptor 50 promotes self-renewal and neuronal differentiation of embryonic neural progenitor cells through regulation of notch and wnt/β-catenin signalingsYan xia Ma
Jiangsu Key Laboratory of Translational Research and Therapy for Neuro Psycho Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu Province 215021, China
Biochem Biophys Res Commun 458:836-42. 2015G protein-coupled receptor 50 (GPR50), a risk factor for major depressive disorder and bipolar affective disorder, is expressed in both the developmental and adult brain. However, the function of GPR50 in the brain remains unknown...
- Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brainsM Batailler
INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
J Neuroendocrinol 24:798-808. 2012b>GPR50, formerly known as melatonin-related receptor, is one of three subtypes of the melatonin receptor subfamily, together with the MT(1) and MT(2) receptors...
- Developmental expression of orphan G protein-coupled receptor 50 in the mouse brainEllen Grünewald
Medical Genetics Section, University of Edinburgh, Institute of Genetics and Molecular Medicine, Molecular Medicine Centre, Crewe Road, Edinburgh EH2 4XU, United Kingdom
ACS Chem Neurosci 3:459-72. 2012..Orphan G protein-coupled receptor 50 (GPR50) has been identified as a genetic risk factor for bipolar disorder and major depression in women, and there is ..
- Increased bone mass in mice lacking the adipokine apelinLalita Wattanachanya
Veterans Affairs Medical Center 111 N, 4150 Clement Street, San Francisco, California 94121, USA
Endocrinology 154:2069-80. 2013..These results indicate that apelin functions as a physiologically significant antianabolic factor in bone in vivo...
- Induction of the metabolic regulator Txnip in fasting-induced and natural torporLaura E Hand
Faculty of Life Sciences, AV Hill Building, University of Manchester, Manchester M13 9PT, UK
Endocrinology 154:2081-91. 2013..We recently showed that mice lacking the orphan G protein-coupled receptor Gpr50 readily enter torpor in response to fasting and have now used these mice to conduct a microarray analysis of ..
- Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)A K Gubitz
Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA
Genomics 55:248-51. 1999..Both genes were found to be X-linked: radiation hybrid mapping revealed that the human H9 gene (GPR50) is localized to Xq28...
- Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominencesWeiguo Feng
Department of Craniofacial Biology, University of Colorado Denver, Aurora, Colorado, USA
PLoS ONE 4:e8066. 2009..Overall, our studies provide a valuable resource for probing orofacial development and a robust dataset for bioinformatic analysis of spatial and temporal gene expression changes during embryogenesis...
- Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminenceAnissa Sidibe
Institut Cochin, Universite Paris Descartes, CNRS, France
J Pineal Res 48:263-9. 2010..is composed of three members, MT(1) and MT(2) receptors that bind melatonin with high affinity and the orphan GPR50 that does not bind melatonin but shares significant sequence homology with the two other subtypes...
- The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant miceCharles J Billington
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455 0356, USA
Dev Biol 355:21-31. 2011..We postulate that variable responses to stress may contribute to variable craniofacial phenotypes by triggering differential expression of genes and variable cellular apoptosis...
- GPR50 interacts with TIP60 to modulate glucocorticoid receptor signallingJian Li
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
PLoS ONE 6:e23725. 2011b>GPR50 is an orphan G-protein coupled receptor most closely related to the melatonin receptors. The physiological function of GPR50 remains unclear, although our previous studies implicate the receptor in energy homeostasis...