GPI HBP1

Summary

Gene Symbol: GPI HBP1
Description: GPI-anchored HDL-binding protein 1
Alias: 1110002J19Rik, GPI-HBP1, glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1, gpihbp1, high density lipoprotein-binding protein 1
Species: mouse

Top Publications

  1. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
  2. pmc The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 22:2496-504. 2008
  3. pmc GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4
    William K Sonnenburg
    Department of Biotherapeutics, Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX 77381, USA
    J Lipid Res 50:2421-9. 2009
  4. pmc Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells
    Brandon S J Davies
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 53:2690-7. 2012
  5. pmc GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 12:42-52. 2010
  6. pmc Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries
    Christopher M Allan
    Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095
    J Lipid Res 58:216-225. 2017
  7. pmc Laminin regulates PDGFRβ(+) cell stemness and muscle development
    Yao Yao
    Laboratory of Neurobiology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nat Commun 7:11415. 2016
  8. pmc Evidence for Two Distinct Binding Sites for Lipoprotein Lipase on Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1)
    Mart Reimund
    From the Department of Chemistry, Tallinn University of Technology, Tallinn 12618, Estonia
    J Biol Chem 290:13919-34. 2015
  9. pmc High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis
    Haibo Jiang
    Materials Department, Oxford University, Oxford, United Kingdom
    J Lipid Res 55:2156-66. 2014
  10. pmc The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries
    Chris N Goulbourne
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 19:849-60. 2014

Scientific Experts

  • Anne Beigneux
  • Pranav Danthi
  • Brandon S J Davies
  • Stephen G Young
  • Michael M Weinstein
  • Loren G Fong
  • Andre Bensadoun
  • Peter Gin
  • Yiping Tu
  • Haibo Jiang
  • Chris N Goulbourne
  • Gunilla Olivecrona
  • Karen Reue
  • Peter Tontonoz
  • Liya Yin
  • Christopher M Allan
  • Yao Yao
  • Mikael Larsson
  • Mart Reimund
  • Angelica Tatar
  • Chris R M Grovenor
  • Chika Nobumori
  • Rakel Nyrén
  • Olessia Kroupa
  • Thomas Olivecrona
  • Evelina Vorrsjö
  • Ira J Goldberg
  • Constance V Voss
  • Richard H Barnes
  • Jeffrey D Esko
  • Tove Olafsen
  • Zala Prevorsek
  • Rosemary L Walzem
  • Constance Voss
  • Xiao Shu
  • S F C Vaessen
  • Robert O Ryan
  • William K Sonnenburg
  • Michael Ploug
  • Rachel S Jung
  • Ryoichi X Ioka
  • Christopher E Mason
  • Erin H Norris
  • Sidney Strickland
  • Aivar Lookene
  • Oleg Kovrov
  • Sergo Kasvandik
  • Andreas Hoenger
  • Oludotun Adeyo
  • Kirsten Turlo
  • Daniel Wu
  • Ryan Davis
  • Anastasia Barmina
  • Valentina Sukonina
  • Steven M Watkins
  • Per Lindstrom
  • Yusuf Ali
  • Christopher N Goulbourne
  • Frits Mattijssen
  • Rinke Stienstra
  • Stefan K Nilsson
  • Chuchun L Chang
  • Sander Kersten
  • Lisa Juntti-Berggren
  • Shelly Tat
  • Charlene D Mottler
  • Christopher Pelletier
  • Koon Pong Wong
  • Aldons J Lusis
  • Beverly Paigen
  • Jennifer A Beckstead
  • Xiaohui Wu
  • Braydon L Burgess
  • Lawrence W Castellani
  • Trudy M Forte
  • Vania E Kenanova
  • Anna M Wu
  • Glen Young
  • Sung Cheng Huang
  • Simon Horvat
  • Gregor Gorjanc
  • Lisa Nelbach
  • Xuping Wang
  • Jason Gay
  • C J D Ross
  • Brian P Zambrowicz
  • F G Schaap
  • J A Kuivenhoven
  • David R Powell
  • Billie Key

Detail Information

Publications26

  1. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
    ..Here, we show that glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) plays a critical role in the lipolytic processing of chylomicrons...
  2. pmc The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 22:2496-504. 2008
    Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), a protein in the lymphocyte antigen 6 (Ly-6) family, plays a key role in the lipolytic processing of triglyceride-rich lipoproteins...
  3. pmc GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4
    William K Sonnenburg
    Department of Biotherapeutics, Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX 77381, USA
    J Lipid Res 50:2421-9. 2009
    Glycosylphosphatidylinositol-anchored HDL-binding protein (GPIHBP1) binds both LPL and chylomicrons, suggesting that GPIHBP1 is a platform for LPL-dependent processing of triglyceride (TG)-rich lipoproteins...
  4. pmc Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells
    Brandon S J Davies
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 53:2690-7. 2012
    ..into the interstitial spaces by adipocytes and myocytes but then must be transported to the capillary lumen by GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells...
  5. pmc GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 12:42-52. 2010
    ..Here, we show that GPIHBP1 is responsible for the transport of LPL into capillaries...
  6. pmc Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries
    Christopher M Allan
    Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095
    J Lipid Res 58:216-225. 2017
    In mice lacking glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 (GPIHBP1), the LPL secreted by adipocytes and myocytes remains bound to heparan sulfate proteoglycans (HSPGs) on all cells within tissues...
  7. pmc Laminin regulates PDGFRβ(+) cell stemness and muscle development
    Yao Yao
    Laboratory of Neurobiology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nat Commun 7:11415. 2016
    ..Further RNAseq analysis reveals that laminin regulates PDGFRβ(+) cell differentiation/fate determination via gpihbp1. These data support a critical role of laminin in the regulation of PDGFRβ(+) cell stemness, identify an ..
  8. pmc Evidence for Two Distinct Binding Sites for Lipoprotein Lipase on Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1)
    Mart Reimund
    From the Department of Chemistry, Tallinn University of Technology, Tallinn 12618, Estonia
    J Biol Chem 290:13919-34. 2015
    b>GPIHBP1 is an endothelial membrane protein that transports lipoprotein lipase (LPL) from the subendothelial space to the luminal side of the capillary endothelium...
  9. pmc High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis
    Haibo Jiang
    Materials Department, Oxford University, Oxford, United Kingdom
    J Lipid Res 55:2156-66. 2014
    ..NanoSIMS imaging provided evidence of defective transport of lipids from the plasma LPs to adipocytes and cardiomyocytes in mice deficient in glycosylphosphatidylinositol-anchored HDL binding protein 1. ..
  10. pmc The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries
    Chris N Goulbourne
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 19:849-60. 2014
    ..by lipoprotein lipase (LPL), an enzyme that is transported to the capillary lumen by an endothelial cell protein, GPIHBP1. For LPL-mediated lipolysis to occur, TRLs must bind to the lumen of capillaries...
  11. pmc Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue
    Olessia Kroupa
    Department of Medical Biosciences Physiological Chemistry, Umea University, Umeå SE 90187, Sweden
    BMC Physiol 12:13. 2012
    ..the expression, in rat adipose tissue, of three such proteins, LMF1, an ER protein necessary for folding of LPL into its active dimeric form, the endogenous LPL inhibitor ANGPTL4, and GPIHBP1, that transfers LPL across the endothelium.
  12. pmc Intravenous injection of apolipoprotein A-V reconstituted high-density lipoprotein decreases hypertriglyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1
    Xiao Shu
    Center for Prevention of Obesity, Cardiovascular Disease and Diabetes, Children s Hospital Oakland Research Institute, Oakland, Calif, USA
    Arterioscler Thromb Vasc Biol 30:2504-9. 2010
    ....
  13. doi Congenic and bioinformatics analyses resolved a major-effect Fob3b QTL on mouse Chr 15 into two closely linked loci
    Zala Prevorsek
    Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230, Domzale, Slovenia
    Mamm Genome 21:172-85. 2010
    ..A high-resolution map along with prioritization of Fob3b1 candidates by bioinformatics represents an important step forward to final identification of the Chr 15 obesity QTL...
  14. pmc Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice
    Michael M Weinstein
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 30:2106-13. 2010
    To determine whether plasma triglyceride levels in adult Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient (Gpihbp1(-/-)) mice would be sensitive to cholesterol intake.
  15. pmc Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice
    Michael M Weinstein
    695 Charles E Young Dr S, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 32:230-5. 2012
    b>Gpihbp1-deficient (Gpihbp1-/-) mice lack the ability to transport lipoprotein lipase to the capillary lumen, resulting in mislocalization of lipoprotein lipase within tissues, defective lipolysis of triglyceride-rich lipoproteins, and ..
  16. pmc Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency
    Rakel Nyrén
    Department of Medical Biosciences Physiological Chemistry, Umea University, Umea, Sweden
    BMC Physiol 12:14. 2012
    ..endothelial anchoring protein glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) in mouse pancreas, and effects of diet and leptin deficiency on their expression patterns...
  17. pmc Bid regulates the pathogenesis of neurotropic reovirus
    Pranav Danthi
    Department of Biology, Indiana University, Bloomington, Indiana, United States of America
    PLoS Pathog 6:e1000980. 2010
    ..These findings define a role for NF-kappaB-dependent cleavage of Bid in the cell death program initiated by viral infection and link Bid to viral virulence...
  18. pmc Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning
    Tove Olafsen
    Department of Molecular and Medical Pharmacology, California NanoSystems Institute, Los Angeles, California 90095, USA
    J Biol Chem 285:39239-48. 2010
    Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), a GPI-anchored endothelial cell protein, binds lipoprotein lipase (LPL) and transports it into the lumen of capillaries where it hydrolyzes ..
  19. pmc Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1
    Constance V Voss
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:7980-4. 2011
    b>GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells, shuttles lipoprotein lipase (LPL) from subendothelial spaces to the capillary lumen...
  20. pmc Chylomicronemia elicits atherosclerosis in mice--brief report
    Michael M Weinstein
    Departments of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 30:20-3. 2010
    ..In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis.
  21. pmc Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:30240-7. 2009
    b>GPIHBP1, a glycosylphosphatidylinositol-anchored endothelial cell protein of the lymphocyte antigen 6 (Ly6) family, binds lipoprotein lipase (LPL) avidly and is required for the lipolytic processing of triglyceride-rich lipoproteins...
  22. pmc Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels
    S F C Vaessen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 50:880-4. 2009
    ..Taken together, the data suggest that higher plasma apoAV levels reflect an increased demand for plasma TG hydrolysis under normal physiological conditions...
  23. pmc Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice
    Michael M Weinstein
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:34511-8. 2008
    b>GPIHBP1-deficient mice (Gpihbp1(-/-)) exhibit severe chylomicronemia...
  24. pmc The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:29554-62. 2008
    b>GPIHBP1, a glycosylphosphatidylinositol-anchored endothelial cell protein of the lymphocyte antigen 6 (Ly6) family, plays a key role in the lipolysis of triglyceride-rich lipoproteins (e.g. chylomicrons)...
  25. pmc Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 49:1312-21. 2008
    b>GPIHBP1 is a glycosylphosphatidylinositol-anchored protein in the lymphocyte antigen 6 (Ly-6) family that recently was identified as a platform for the lipolytic processing of triglyceride-rich lipoproteins...
  26. ncbi Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1
    Ryoichi X Ioka
    Tohoku University Gene Research Center, Sendai 981 8555, Japan
    J Biol Chem 278:7344-9. 2003
    ..In situ hybridization revealed the accumulation of GPI-HBP1 transcripts in cardiac muscle cells, hepatic Kupffer cells and sinusoidal endothelium, and bronchial epithelium and alveolar macrophages in the lung...