Gp1ba

Summary

Gene Symbol: Gp1ba
Description: glycoprotein 1b, alpha polypeptide
Alias: GPIba, GPIbalpha, platelet glycoprotein Ib alpha chain, GP-Ib alpha, glycoprotein Ibalpha
Species: mouse

Top Publications

  1. ncbi Cloning of the murine platelet glycoprotein Ibalpha gene highlighting species-specific platelet adhesion
    J Ware
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood Cells Mol Dis 23:292-301. 1997
  2. ncbi Molecular modeling of the seven tandem leucine-rich repeats within the ligand-binding region of platelet glycoprotein Ib alpha
    James C Whisstock
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Thromb Haemost 87:329-33. 2002
  3. ncbi Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome
    Taisuke Kanaji
    Roon Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 100:2102-7. 2002
  4. ncbi Distinct antithrombotic consequences of platelet glycoprotein Ibalpha and VI deficiency in a mouse model of arterial thrombosis
    S Konstantinides
    Department of Molecular and Experimental Medicine, Division of Experimental Hemostasis and Thrombosis, The Roon Center for Arteriosclerosis and Thrombosis, The Scripps Research Institute, La Jolla, CA, USA
    J Thromb Haemost 4:2014-21. 2006
  5. pmc The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
    Wolfgang Bergmeier
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16900-5. 2006
  6. pmc Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin
    A Y Mehta
    Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA
    J Thromb Haemost 14:828-38. 2016
  7. doi Blocking von Willebrand factor for treatment of cutaneous inflammation
    Carina Hillgruber
    1 Department of Dermatology, University Hospital of Munster, Munster, Germany 2 Interdisciplinary Center for Clinical Research IZKF, University of Munster, Munster, Germany
    J Invest Dermatol 134:77-86. 2014
  8. pmc Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia
    Taisuke Kanaji
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
    Blood 122:2732-42. 2013
  9. pmc Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality
    Hong Yin
    From the Department of Pharmacology, College of Medicine H Y, A s, W X, A Z, F Q, A K, A V L, X D, Department of Biopharmaceutical Sciences, College of Pharmacy Z J W, and Department of Pathology S P, University of Illinois at Chicago and Department of Physiology and Biophysics, University of Arkansas for Medical Sciences A C, J W
    Arterioscler Thromb Vasc Biol 33:2529-37. 2013
  10. doi GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice
    Audrey Le Béhot
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche Scientifique U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, Groupement d Intérêt Public Cyceron, Caen, France
    Blood 123:3354-63. 2014

Research Grants

Scientific Experts

  • Ana Kasirer-Friede
  • J Ware
  • L G Guidotti
  • Carol A De La Motte
  • Wei Hsiung Yang
  • Taisuke Kanaji
  • Klaus Ley
  • Wolfgang Bergmeier
  • Bernhard Nieswandt
  • John Freedman
  • Heyu Ni
  • Cecile V Denis
  • Guangheng Zhu
  • Zaverio M Ruggeri
  • Adili Reheman
  • Hong Yang
  • Jose A Guerrero
  • Susan Russell
  • A Y Mehta
  • Rebecca I Schleicher
  • Sue Chandraratne
  • Zane S Kaplan
  • June Li
  • Z M Ruggeri
  • Carina Hillgruber
  • Jianchung Chen
  • Audrey Le Béhot
  • E K Koltsova
  • Karin M Hoffmeister
  • Dianne E van der Wal
  • Yacine Boulaftali
  • Alessandro Zarpellon
  • Justin D Barr
  • Hong Yin
  • Shujian Wei
  • Steffen Massberg
  • A J Gerard Jansen
  • Judith M E M Cosemans
  • Conglei Li
  • Admar Verschoor
  • Peter L Gross
  • Sean Lang
  • Pingguo Chen
  • Christopher M Spring
  • Youjun Li
  • Denisa D Wagner
  • Larry J Suva
  • Isabelle Marx
  • Jonas Emsley
  • Matteo Iannacone
  • T Kent Gartner
  • Kylie D Mason
  • Shashank Jain
  • C Strassel
  • Liyan Pang
  • S Konstantinides
  • Barsom Aktas
  • U R Desai
  • D F Brophy
  • B M Mohammed
  • E J Martin
  • D Gailani
  • Harald F Langer
  • Florian Gärtner
  • Franziska Todt
  • Jun Peng
  • Laurenz Pauleikhoff
  • Anil Kumar
  • Frank Edlich
  • Gerald Assmann
  • Simone M Schoenwaelder
  • Zhi Min Zhai
  • Ming Hou
  • Tobias Geisler
  • Peter Kraft
  • Amélia Caballero-Martinez
  • Lingyan Zhu
  • Brian Vadasz
  • Mario Lescan
  • Ingo Hilgendorf
  • Frank Reichenbach
  • Martin Schaller
  • Li Ma
  • Eike Kleinert
  • Lorraine O'Reilly
  • Marcus Olbrich
  • Josef Mueller-Hoecker
  • Omari Chillo
  • Klaus Schulze-Osthoff
  • Renata Grozovsky

Detail Information

Publications50

  1. ncbi Cloning of the murine platelet glycoprotein Ibalpha gene highlighting species-specific platelet adhesion
    J Ware
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood Cells Mol Dis 23:292-301. 1997
    ..The results further define the structural elements necessary for the interaction of human vWF and platelets...
  2. ncbi Molecular modeling of the seven tandem leucine-rich repeats within the ligand-binding region of platelet glycoprotein Ib alpha
    James C Whisstock
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Thromb Haemost 87:329-33. 2002
    ..This provides the basis for relating these genetic lesions to abnormal function of the receptor...
  3. ncbi Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome
    Taisuke Kanaji
    Roon Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 100:2102-7. 2002
    ..These results provide in vivo insights into the structural elements of the GP Ibalpha subunit that contribute to normal megakaryocyte maturation and thrombopoiesis...
  4. ncbi Distinct antithrombotic consequences of platelet glycoprotein Ibalpha and VI deficiency in a mouse model of arterial thrombosis
    S Konstantinides
    Department of Molecular and Experimental Medicine, Division of Experimental Hemostasis and Thrombosis, The Roon Center for Arteriosclerosis and Thrombosis, The Scripps Research Institute, La Jolla, CA, USA
    J Thromb Haemost 4:2014-21. 2006
    ..Collagen and von Willebrand factor (VWF) are considered essential to initiate platelet deposition at sites of vascular injury, but their respective roles remain to be elucidated...
  5. pmc The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
    Wolfgang Bergmeier
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16900-5. 2006
    b>GPIbalpha binding to von Willebrand factor (VWF) exposed at a site of vascular injury is thought to be the first step in the formation of a hemostatic plug...
  6. pmc Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin
    A Y Mehta
    Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA
    J Thromb Haemost 14:828-38. 2016
    ..Recently, we designed sulfated β-O4 lignin (SbO4L) as an allosteric inhibitor that targets exosite 2 of thrombin to reduce fibrinogen cleavage through allostery and compete with glycoprotein Ibα to reduce platelet activation...
  7. doi Blocking von Willebrand factor for treatment of cutaneous inflammation
    Carina Hillgruber
    1 Department of Dermatology, University Hospital of Munster, Munster, Germany 2 Interdisciplinary Center for Clinical Research IZKF, University of Munster, Munster, Germany
    J Invest Dermatol 134:77-86. 2014
    ..Of particular importance, anti-VWF treatment was effective both in prophylactic and therapeutic administration. Thus, VWF represents a promising target for the treatment of cutaneous inflammation, e.g., leukocytoclastic vasculitis. ..
  8. pmc Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia
    Taisuke Kanaji
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
    Blood 122:2732-42. 2013
    ..Intercalation of plant sterols into the plasma membrane therefore results in dysregulation of multiple platelet activation pathways, leading to macrothrombocytopenia and bleeding. ..
  9. pmc Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality
    Hong Yin
    From the Department of Pharmacology, College of Medicine H Y, A s, W X, A Z, F Q, A K, A V L, X D, Department of Biopharmaceutical Sciences, College of Pharmacy Z J W, and Department of Pathology S P, University of Illinois at Chicago and Department of Physiology and Biophysics, University of Arkansas for Medical Sciences A C, J W
    Arterioscler Thromb Vasc Biol 33:2529-37. 2013
    ..Thus, we have investigated the role of GPIb-IX in LPS-induced platelet adhesion, thrombosis, and thrombocytopenia...
  10. doi GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice
    Audrey Le Béhot
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche Scientifique U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, Groupement d Intérêt Public Cyceron, Caen, France
    Blood 123:3354-63. 2014
    ....
  11. pmc Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis
    E K Koltsova
    Klaus Ley, MD, Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, USA, Fax 1 858 752 6985, E mail
    Thromb Haemost 112:1252-63. 2014
    ..Thus, atherosclerosis reduction in mice lacking GPIbα may not result from the defective GPIbα-ligand binding, but more likely is a consequence of functional defects of GPIbα-/- platelets and reduced blood platelet counts. ..
  12. pmc Exploiting the kinetic interplay between GPIbα-VWF binding interfaces to regulate hemostasis and thrombosis
    Jianchung Chen
    Department of Pediatrics, Columbia University Medical Center, New York, NY
    Blood 124:3799-807. 2014
    ....
  13. doi Immunosurveillance of the liver by intravascular effector CD8(+) T cells
    Luca G Guidotti
    Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA Electronic address
    Cell 161:486-500. 2015
    ..These findings reveal the dynamic behavior whereby CD8 TE control hepatotropic pathogens and suggest how liver fibrosis might reduce CD8 TE immune surveillance toward infected or transformed hepatocytes...
  14. pmc Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
    June Li
    1 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 2 Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada M5B 1W8 3 Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St Michael s Hospital, Toronto, Ontario, Canada M5B 1W8
    Nat Commun 6:7737. 2015
    ..These findings shed light on Fc-independent cytopenias, designating desialylation as a potential diagnostic biomarker and therapeutic target in the treatment of refractory ITP. ..
  15. doi Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4
    Zane S Kaplan
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia
    Nat Commun 6:7835. 2015
    ..Dysregulation of this checkpoint mechanism is likely to contribute to the development of thromboinflammatory disorders. ..
  16. pmc Platelets induce apoptosis via membrane-bound FasL
    Rebecca I Schleicher
    Department of Cardiovascular Medicine, Section for Cardioimmunology, and Department of Cardiovascular Medicine, University Hospital, Eberhard Karls University, Tuebingen, Germany
    Blood 126:1483-93. 2015
    ..Because apoptosis secondary to injury prevents inflammation, our findings describe a novel mechanism on how PLTs contribute to tissue homeostasis. ..
  17. doi Critical role of platelet glycoprotein ibα in arterial remodeling
    Sue Chandraratne
    From the Medizinische Klinik und Poliklinik I, Department of Cardiology S C, M L v B, K S, I K, S F, R C, F G, K R L, M L, A T, C S, S M, Walter Brendel Centre of Experimental Medicine S C, M L v B, J I P, K S, E K, I K, S F, R C, F G, O C, K R L, M L, S R, A C M, A T, L P, C S, E D, Department of Internal Medicine
    Arterioscler Thromb Vasc Biol 35:589-97. 2015
    ..On the basis of previous findings that platelets are central players in inflammatory processes and mediate the recruitment of leukocytes, the aim of this study was to assess the role of platelets in a model of arterial remodeling...
  18. pmc Red blood cells mediate the onset of thrombosis in the ferric chloride murine model
    Justin D Barr
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Blood 121:3733-41. 2013
    ..These findings illuminate the mechanisms of FeCl(3)-mediated thrombosis and reveal a previously unrecognized ability of RBCs to participate in thrombosis by mediating platelet adhesion to the intact endothelial surface...
  19. doi A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3
    Admar Verschoor
    Institute for Medical Microbiology, Immunology and Hygiene, and Focus Group, Clinical Cell Processing and Purification, Technische Universitat Munchen, Munich, Germany
    Nat Immunol 12:1194-201. 2011
    ..Other gram-positive bacteria also were rapidly tagged by platelets, revealing a broadly active shuttling mechanism for systemic bacteria...
  20. pmc Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice
    A J Gerard Jansen
    Translational Medicine Division, Brigham and Women s Hospital, Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA
    Blood 119:1263-73. 2012
    ..Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbα and GPV for MP-dependent cleavage...
  21. pmc GPIbα regulates platelet size by controlling the subcellular localization of filamin
    Taisuke Kanaji
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53266 3548, USA
    Blood 119:2906-13. 2012
    ..Taken together, these data demonstrate that coordinated expression of GPIbα and filamin is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets...
  22. pmc Platelet IκB kinase-β deficiency increases mouse arterial neointima formation via delayed glycoprotein Ibα shedding
    Shujian Wei
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Emergency, Qilu Hospital, Shandong University, Jinan, Shandong, China
    Arterioscler Thromb Vasc Biol 33:241-8. 2013
    ..The transcription factor nuclear factor-κB is a critical molecule in platelet activation. Here, we investigated the role of the platelet nuclear factor-κB pathway in forming arterial neointima after arterial injury...
  23. ncbi Programmed anuclear cell death delimits platelet life span
    Kylie D Mason
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell 128:1173-86. 2007
    ....
  24. pmc Platelet ITAM signaling is critical for vascular integrity in inflammation
    Yacine Boulaftali
    McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Clin Invest 123:908-16. 2013
    ....
  25. pmc The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies
    Conglei Li
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 121:4537-47. 2011
    ..These results suggest that a similar pathology may have masked the severity and frequency of human anti-GPIbα-mediated FNIT, but also point to possible therapeutic interventions...
  26. pmc Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines
    Carol de la Motte
    Lerner Research Institute, NC2, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Pathol 174:2254-64. 2009
    ..The platelet may thus provide an interface between acute and chronic inflammation, wound healing, and their subsequent fibrotic responses...
  27. doi Synergistic activation of the Mc2r promoter by FOXL2 and NR5A1 in mice
    Wei Hsiung Yang
    Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia 31404 3089, USA
    Biol Reprod 83:842-51. 2010
    ..These results suggest that the interplay between FOXL2 and NR5A1 on the Mc2r promoter functions as a novel mechanism for regulating MC2R-mediated cell signaling as well as steroidogenesis in adrenal glands...
  28. pmc Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation
    Jose A Guerrero
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Blood 114:5541-6. 2009
    ..Visualization of the receptor/ligand interaction and characterization of a severe antithrombotic phenotype provide a new understanding on the molecular basis of bleeding associated with the PT-VWD phenotype...
  29. pmc Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow
    Judith M E M Cosemans
    Department of Biochemistry, Maastricht University MedicalCentre, Maastricht, The Netherlands
    Blood 117:651-60. 2011
    ..This process can be relevant in hemostasis and the manifestation of von Willebrand disease...
  30. ncbi In vivo expression of murine platelet glycoprotein Ibalpha
    H Fujita
    Roon Research Center for Arteriosclerosis and Thrombosis, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 92:488-95. 1998
    ....
  31. pmc Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome
    J Ware
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:2803-8. 2000
    ..Thus, an in vivo model is defined for analysis of the human GP Ib-IX-V receptor and its role in the processes performed exclusively by megakaryocytes and platelets...
  32. ncbi Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins
    P Andre
    Center for Blood Research and the Department of Pathology, Harvard Medical School, Boston, MA, USA
    Blood 96:3322-8. 2000
    ..The adhesion was mediated by platelet glycoprotein Ibalpha (GPIbalpha) because the adhesion of murine platelets expressing exclusively the human GPIbalpha could be ..
  33. ncbi Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11
    J W Watters
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Genomics 73:223-31. 2001
    ..Additionally, a region of 100 kb or more is deleted in the Ltxs1 interval of some strains. Our genetic, physical, and transcript map provides an important resource for the molecular cloning of Ltxs1...
  34. ncbi Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model
    Christel Poujol
    UMR 5533 CNRS, Laboratoire d Hematologie, Hopital Cardiologique, Avenue de Magellan, 33604 Pessac, France
    Exp Hematol 30:352-60. 2002
    ..Molecular defects in the genes for GPIbalpha, GPIbbeta, and GPIX give rise to the Bernard-Soulier syndrome, in which thrombocytopenia and giant platelets ..
  35. ncbi Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation
    Sarah Uff
    Department of Biochemistry, University of Leicester, Leicester LE1 7RH, United Kingdom
    J Biol Chem 277:35657-63. 2002
    ..Using molecular docking of the GPIb and vWF-A1 crystal structures, we were also able to model the GPIb.vWF-A1 complex...
  36. ncbi Megakaryocyte proliferation and ploidy regulated by the cytoplasmic tail of glycoprotein Ibalpha
    Taisuke Kanaji
    Department of Molecular and Experimental Medicine, Division of Experimental Hemostasis and Thrombosis, Roon Research Center for Arteriosclerosis and Thrombosis, MEM175, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 104:3161-8. 2004
    ..Using a Gp1ba(-/-) mouse colony, we compared the rescued phenotypes produced by a wild-type human GP Ibalpha allele or a similar ..
  37. ncbi Aspirin induces platelet receptor shedding via ADAM17 (TACE)
    Barsom Aktas
    Rudolf Virchow Center for Experimental Biomedicine, Versbacherstrasse 9, 97078 Wurzburg, Germany
    J Biol Chem 280:39716-22. 2005
    ..whole blood, aspirin, but not its metabolite salicylic acid, induced dose-dependent shedding of human and murine GPIbalpha and GPV from the platelet surface, whereas other glycoproteins remained unaffected by this treatment...
  38. pmc Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins
    Liyan Pang
    Children s Hospital of Philadelphia, ARC 316H, 3165 Civic Center Blvd, Philadelphia, PA, USA
    Blood 108:2198-206. 2006
    ..In concert, these data reveal disparate, but overlapping, functions of Ets transcription factors at distinct stages of megakaryocyte maturation...
  39. pmc ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla 92093 0726, USA
    Blood 109:1018-25. 2007
    ..These studies establish ADAP as a component of inside-out signaling pathways that couple GP Ib-IX-V and other platelet agonist receptors to alphaIIbbeta3 activation...
  40. ncbi Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome
    C Strassel
    INSERM U 311, Etablissement Francais du Sang Alsace, 10 rue Spielmann, BP 36, 67065 Strasbourg Cedex, France
    Arterioscler Thromb Vasc Biol 27:241-7. 2007
    ..To evaluate the consequences of GPIb-V-IX deficiency in thrombosis we generated mouse models of the disease by targeting the GPIb beta subunit...
  41. pmc Platelet glycoprotein Ib alpha supports experimental lung metastasis
    Shashank Jain
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Proc Natl Acad Sci U S A 104:9024-8. 2007
    ..Our results support the hypothesis that platelet GP Ib-IX functions that support normal hemostasis or pathologic thrombosis also contribute to tumor malignancy...
  42. pmc Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:629-34. 2008
    ....
  43. pmc Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease
    Larry J Suva
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Pathol 172:430-9. 2008
    ..These studies provide new insights into the relationship between the regulation of megakaryocytopoiesis and bone mass...
  44. doi Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa
    Isabelle Marx
    Inserm U770 and Universite Paris Sud, Le Kremlin Bicetre, France
    Blood 112:603-9. 2008
    ..Our observations suggest that targeting the VWF-collagen or VWF-GPIIbIIIa interactions could be an interesting alternative for new antithrombotic strategies...
  45. pmc Modularity of the oncoprotein-like properties of platelet glycoprotein Ibalpha
    Youjun Li
    Section of Hematology Oncology, Children s Hospital of Pittsburgh Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 284:1410-8. 2009
    Glycoprotein Ib alpha (GpIbalpha), a trans-membrane glycoprotein, is expressed on the surface of megakaryocytes and platelets, where, in association with glycoprotein Ib beta, glycoprotein V, and glycoprotein IX, it normally forms the ..
  46. doi Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor
    Adili Reheman
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Blood 113:1809-17. 2009
    ..inhibited by our newly developed mouse anti-mouse beta(3) integrin antibodies but was not affected by anti-mouse GPIbalpha antibodies...
  47. doi Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression
    Hong Yang
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Blood 114:425-36. 2009
    ..Since human fibrinogen levels vary significantly in normal and diseased populations, P-selectin as an activation marker on platelets should be used with caution...

Research Grants3

  1. BIOMECHANICS OF LEUKOCYTE ADHESION MOLECULES
    Klaus Ley; Fiscal Year: 2002
    ..Milestones for the following years are listed in the timeline. ..
  2. SELECTIN MEDIATED LEUKOCYTE ADHESION IN VIVO
    Klaus Ley; Fiscal Year: 2002
    ..The knowledge gained will improve the understanding of the inflammatory process and provide significant information pertinent to the development of potential anti-inflammatory therapies for future clinical use in patients. ..
  3. MONOCYTE ADHESION TO ATHEROMA IN GENE TARGETED MICE
    Klaus Ley; Fiscal Year: 2009
    ..The proposed work may enable the design of interventions into the chemokine network to stabilize atherosclerotic plaques by reducing their content of inflammatory cells. ..