Genomes and Genes
Gene Symbol: Gnat2
Description: guanine nucleotide binding protein, alpha transducing 2
Alias: AW490837, Gnat-2, Gt-2, Tcalpha, guanine nucleotide-binding protein G(t) subunit alpha-2, transducin alpha-2 chain
- Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2Bo Chang
The Jackson Laboratory, Bar Harbor, Maine, USA
Invest Ophthalmol Vis Sci 47:5017-21. 2006..To report a novel mouse model of achromatopsia with a cpfl3 mutation found in the ALS/LtJ strain...
- Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunitP D Calvert
Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 97:13913-8. 2000..These results indicate that most if not all rods use a single transducin type in phototransduction...
- Speed, spatial, and temporal tuning of rod and cone vision in mouseYumiko Umino
Center for Vision Research, Department of Ophthalmology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
J Neurosci 28:189-98. 2008..forced-choice measures of contrast thresholds for optomotor responses of C57BL/6J mice with normal vision, Gnat2(cpfl3) mice without functional cones, and Gnat1-/- mice without functional rods. Gnat2(cpfl3) mice (threshold, -6...
- Functional interchangeability of rod and cone transducin alpha-subunitsWen tao Deng
Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
Proc Natl Acad Sci U S A 106:17681-6. 2009..expressed in cones and cone Talpha expressed in rods in three mouse strains: rod Talpha knockout, cone Talpha GNAT2(cpfl3) mutant, and rod and cone Talpha double mutant rd17 mouse...
- A visual circuit uses complementary mechanisms to support transient and sustained pupil constrictionWilliam Thomas Keenan
Department of Biology, Johns Hopkins University, Baltimore, United States
elife 5:. 2016..These results highlight a temporal switch in the coding mechanisms of a neural circuit to support proper behavioral dynamics...
- M1 ipRGCs Influence Visual Function through Retrograde Signaling in the RetinaCameron L Prigge
Eye Research Institute, Oakland University, Rochester, Michigan 48309
J Neurosci 36:7184-97. 2016..Together, the results strongly suggest that ipRGCs transmit luminance signals retrogradely to the outer retina through the dopaminergic system and in turn influence retinal light adaptation...
- Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse RetinaJianhai Du
From the Department of Biochemistry, Department of Ophthalmology, University of Washington, Seattle, Washington 98109
J Biol Chem 291:4698-710. 2016..In addition, a comprehensive analysis of the retinal metabolome showed that phototransduction also influences steady-state concentrations of 5'-GMP, ribose-5-phosphate, ketone bodies, and purines. ..
- Alternative Splicing Shapes the Phenotype of a Mutation in BBS8 To Cause Nonsyndromic Retinitis PigmentosaDaniel Murphy
Department of Biochemistry, Robert C Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, USA
Mol Cell Biol 35:1860-70. 2015..These intronic sequences are sufficient for photoreceptor-cell-specific splicing of heterologous exons, including an exon with a randomized sequence. ..
- Retinal output changes qualitatively with every change in ambient illuminanceAlexandra Tikidji-Hamburyan
Retinal Circuits and Optogenetics, Centre for Integrative Neuroscience and Bernstein Center for Computational Neuroscience, University of Tubingen, Tubingen, Germany
Nat Neurosci 18:66-74. 2015..This finding raises questions about signal processing within the retina and has implications for visual processing in higher brain areas. ..
- Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibitionTamas Szikra
Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Nat Neurosci 17:1728-35. 2014..Our results show that the retinal circuitry repurposes rods, when they are not directly sensing light, to relay cone-driven surround inhibition. ..
- Spatial organization of AMPAR subtypes in ON RGCsRebecca S Jones
Dominick P Purpura Department of Neuroscience and Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, The Rose F Kennedy Center, Bronx, New York 10461
J Neurosci 34:656-61. 2014..Together, our data suggest that the spatial organization of AMPARs at ON RGCs synapses allows for selective, intensity-dependent activation of AMPARs with distinct subunit composition. ..
- Photoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cellsXiwu Zhao
Kellogg Eye Center, 1000 Wall Street, Ann Arbor, MI 48105, USA
J Physiol 592:1619-36. 2014....
- P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesisSanae Sakami
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Hum Mol Genet 23:1723-41. 2014..These findings provide fundamental insights into the pathogenesis of the P23H mutant opsin and reveal a novel early sagittally aligned disc formation step in normal ROS disc expansion. ..
- In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal developmentHong Cheng
Neuroscience Graduate Program, Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA
Hum Mol Genet 15:2588-602. 2006..Our studies reveal a critical role of NR2E3 in establishing functional specificity of NRL-expressing photoreceptor precursors during retinal neurogenesis...
- Scotopic and photopic visual thresholds and spatial and temporal discrimination evaluated by behavior of mice in a water mazeJanaki Nathan
Department of Biochemistry, University of Washington, Seattle, WA, USA
Photochem Photobiol 82:1489-94. 2006..In this report we describe the sensitivities of rod-mediated and cone-mediated vision using GNAT1-/-and GNAT2-/- mice. Cone-mediated vision is approximately 10,000 times less sensitive than rod-mediated vision in mice...
- Spectral and temporal sensitivity of cone-mediated responses in mouse retinal ganglion cellsYanbin V Wang
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48105, USA
J Neurosci 31:7670-81. 2011..In mice lacking cone function (Gnat2(cpfl3)), light-adapted rod-mediated responses peaked at ∼ 5-7 Hz...
- A naturally occurring mouse model of achromatopsia: characterization of the mutation in cone transducin and subsequent retinal phenotypeAndrew I Jobling
Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Victoria, Australia
Invest Ophthalmol Vis Sci 54:3350-9. 2013This work investigates a novel, naturally occurring mouse model of achromatopsia. The specific missense mutation within the Gnat2 gene was identified and the subsequent retinal phenotype characterized.
- Survey of common eye diseases in laboratory mouse strainsBo Chang
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Invest Ophthalmol Vis Sci 54:4974-81. 2013..These eye diseases are retinal degeneration 1 (Pde6b(rd1)), retinal degeneration 8 (Crb1(rd8)), and cone photoreceptor function loss 3 (Gnat2(cpfl3)).
- Golf: an olfactory neuron specific-G protein involved in odorant signal transductionD T Jones
Howard Hughes Medical Institute, Department of Molecular Biology and Genetic Johns Hopkins School of Medicine, Baltimore, MD 21205
Science 244:790-5. 1989..The expression of Golf alpha in S49 cyc- kin- cells, a line deficient in endogenous stimulatory G proteins, demonstrates its capacity to stimulate adenylate cyclase in a heterologous system...
- Restoration of cone vision in a mouse model of achromatopsiaJohn J Alexander
Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Nat Med 13:685-7. 2007..Using adeno-associated virus (AAV) gene therapy, we show that it is possible to target cones and rescue both the cone-mediated electroretinogram response and visual acuity in the Gnat2 ( cpfl3 ) mouse model of achromatopsia.
- Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and humanC Blatt
Weizmann Institute, Rehovoth, Israel
Proc Natl Acad Sci U S A 85:7642-6. 1988..The retinal-specific transducin subunit genes GNAT1 and GNAT2 were on chromosomes 3 and 1; GNAI1, GNAI2, and GNAI3 were assigned to chromosomes 7, 3, and 1, respectively; GNAZ ..
- Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factorsM A Lochrie
Science 228:96-9. 1985..Amino acid sequence similarity between T alpha and ras is confined to these regions of the molecules...
- Expression of cone transducin, Gz alpha, and other G-protein alpha-subunit messenger ribonucleic acids in pancreatic isletsJ M Zigman
Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
Endocrinology 135:31-7. 1994..We conclude that islet cells express multiple G-proteins, including several that are normally expressed at high levels in certain neuronal cells...
- Chinese hamster transducin gene (GNAT2): genomic organization and peptide conservationB Baron
Unité de Génétique Somatique, Département d immunologie de l Institut Pasteur LA CNRS n degrees 1960, Paris, France
Mamm Genome 7:922-3. 1996
- Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and ratS Vincent Wu
Center for Ulcer Research and Education, Department of Medicine, David Geffen School of Medicine, and Molecular Biology Institute, University of California and Veterans Affairs Greater Los Angeles Healthcare System, 90095, USA
Physiol Genomics 22:139-49. 2005....
- Characterization of a transgenic mouse line lacking photoreceptor development within the ventral retinaShao Ling Fong
Department of Ophthalmology, Indiana University, 702 Rotary Circle, Indianapolis, IN 46202, USA
Exp Eye Res 81:376-88. 2005..line was generated by incorporating a minigene that contained a cone-specific human cone transducin alpha-subunit (GNAT2) promoter, an attenuated diphtheria toxin A (DTA) gene, and an enhancer element from human interphotoreceptor ..
- Visual responses in mice lacking critical components of all known retinal phototransduction cascadesAnnette E Allen
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
PLoS ONE 5:e15063. 2010..injection of U73122 (a phospholipase C antagonist), but is inhibited by a missense mutation of cone α transducin (Gnat2(cpfl3)), suggesting Gnat2-dependence...
- Dark light, rod saturation, and the absolute and incremental sensitivity of mouse cone visionFrank Naarendorp
Department of Psychology, Northeastern University, Boston, Massachusetts 02115, USA
J Neurosci 30:12495-507. 2010..dissect the contributions of rod and cone pathways, both wild-type mice and mice lacking rod (Gnat1(-/-)) or cone (Gnat2(cpfl3)) function were studied...
- Rod photoreceptors drive circadian photoentrainment across a wide range of light intensitiesCara M Altimus
Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Neurosci 13:1107-12. 2010..Thus, rods use two distinct retinal circuits to drive ipRGC function to support circadian photoentrainment across a wide range of light intensities...
- Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal developmentHiroki Fujieda
Department of Anatomy, School of Medicine, Tokyo Women s Medical University, Tokyo, Japan
J Neurochem 108:91-101. 2009..Our data suggest that RORalpha plays a crucial role in cone development by directly regulating multiple cone genes...
- Temporal response properties of the primary and secondary rod-signaling pathways in normal and Gnat2 mutant miceS Nusinowitz
Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA, USA
Exp Eye Res 84:1104-14. 2007..C57BL/6J and Gnat2(cpfl3) mutant mice lacking functional cones were used in these experiments...
- Ethanol-induced conditioned taste aversion in BXD recombinant inbred miceF O Risinger
Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, 97201 3098, USA
Alcohol Clin Exp Res 22:1234-44. 1998..Some of these genes appear to influence taste sensitivity, whereas others appear to mediate sensitivity to aversive pharmacological effects of ethanol...
- Genetics of Age-Related CataractsBo Chang; Fiscal Year: 2007..abstract_text> ..