Gnas

Summary

Gene Symbol: Gnas
Description: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Alias: 5530400H20Rik, A930027G11Rik, C130027O20Rik, GPSA, GSP, Galphas, Gnas1, Gnasxl, Gs-alpha, Gsa, Nesp, Nesp55, Nespl, Oed-Sml, Oedsml, PHP1A, PHP1B, POH, SCG6, protein ALEX, protein GNAS, protein SCG6 (secretogranin VI), Gs alpha subunit, adenylate cyclase-stimulating G alpha protein, alternative gene product encoded by XL-exon, extra large alphas protein, guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, neuroendocrine secretory protein 55, secretogranin VI, stimulatory G-protein alpha subunit
Species: mouse

Top Publications

  1. ncbi Molecular cloning and characterization of NESP55, a novel chromogranin-like precursor of a peptide with 5-HT1B receptor antagonist activity
    R Ischia
    Department of Pharmacology, University of Innsbruck, A 6020 Innsbruck, Austria
    J Biol Chem 272:11657-62. 1997
  2. ncbi Targeted disruption of Gnas in embryonic stem cells
    W F Schwindinger
    Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 138:4058-63. 1997
  3. pmc Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene
    S Yu
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:8715-20. 1998
  4. pmc Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins
    B E Hayward
    Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 95:15475-80. 1998
  5. pmc A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2
    J Peters
    Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxfordshire, OX11 0RD, United Kingdom
    Proc Natl Acad Sci U S A 96:3830-5. 1999
  6. ncbi Identification of imprinted loci by methylation-sensitive representational difference analysis: application to mouse distal chromosome 2
    G Kelsey
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    Genomics 62:129-38. 1999
  7. pmc Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism
    S Yu
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA
    J Clin Invest 105:615-23. 2000
  8. pmc An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus
    S F Wroe
    Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxfordshire, OX11 0RD, United Kingdom
    Proc Natl Acad Sci U S A 97:3342-6. 2000
  9. pmc Identification of a methylation imprint mark within the mouse Gnas locus
    J Liu
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:5808-17. 2000
  10. ncbi Characterization of the extra-large G protein alpha-subunit XLalphas. II. Signal transduction properties
    M Klemke
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    J Biol Chem 275:33633-40. 2000

Research Grants

  1. Circulating osteogenic cells in aging and disease
    Robert Pignolo; Fiscal Year: 2007
  2. BHLH FACTOR IN DIABETES & PANCREAS DEVELOPMENT
    DEBRA BRAMBLETT; Fiscal Year: 2003
  3. Regulation of Meiotic Arrest in Oocytes by G-Proteins
    LISA MEHLMANN; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications126 found, 100 shown here

  1. ncbi Molecular cloning and characterization of NESP55, a novel chromogranin-like precursor of a peptide with 5-HT1B receptor antagonist activity
    R Ischia
    Department of Pharmacology, University of Innsbruck, A 6020 Innsbruck, Austria
    J Biol Chem 272:11657-62. 1997
    ..We describe here the molecular characterization of NESP55 (neuroendocrine secretory protein of Mr 55,000), a novel member of the chromogranins...
  2. ncbi Targeted disruption of Gnas in embryonic stem cells
    W F Schwindinger
    Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 138:4058-63. 1997
    ..As the first step in generating a model of Albright hereditary osteodystrophy, the gene encoding G alpha(s) (Gnas) was disrupted in mouse embryonic stem (ES) cells by homologous recombination...
  3. pmc Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene
    S Yu
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:8715-20. 1998
    ..by short stature, obesity, and skeletal defects, is associated with heterozygous inactivating mutations of GNAS1, the gene encoding the heterotrimeric G protein alpha-subunit (Gsalpha) that couples multiple receptors to the ..
  4. pmc Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins
    B E Hayward
    Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 95:15475-80. 1998
    ..The more 5' of these exons encodes the neuroendocrine secretory protein NESP55, which is expressed exclusively from the maternal allele...
  5. pmc A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2
    J Peters
    Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxfordshire, OX11 0RD, United Kingdom
    Proc Natl Acad Sci U S A 96:3830-5. 1999
    ..differences, to isolate candidate imprinted genes in distal Chr 2 and found two oppositely imprinted genes, Gnasxl and Nesp...
  6. ncbi Identification of imprinted loci by methylation-sensitive representational difference analysis: application to mouse distal chromosome 2
    G Kelsey
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    Genomics 62:129-38. 1999
    ..of imprinted methylation: paternal-specific methylation at the Nesp locus and maternal-specific methylation at the Gnasxl locus...
  7. pmc Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism
    S Yu
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA
    J Clin Invest 105:615-23. 2000
    Heterozygous disruption of Gnas, the gene encoding the stimulatory G-protein alpha subunit (G(s)alpha), leads to distinct phenotypes depending on whether the maternal (m-/+) or paternal (+/p-) allele is disrupted...
  8. pmc An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus
    S F Wroe
    Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxfordshire, OX11 0RD, United Kingdom
    Proc Natl Acad Sci U S A 97:3342-6. 2000
    ..It contains three imprinted genes in the order Nesp-Gnasxl-Gnas...
  9. pmc Identification of a methylation imprint mark within the mouse Gnas locus
    J Liu
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:5808-17. 2000
    ..is maternally expressed in some tissues and biallelically expressed in most other tissues, while the gene products NESP55 and XLalphas are maternally and paternally expressed, respectively...
  10. ncbi Characterization of the extra-large G protein alpha-subunit XLalphas. II. Signal transduction properties
    M Klemke
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    J Biol Chem 275:33633-40. 2000
    ..protein consisting of a novel 37-kDa XL domain followed by a 41-kDa alphas domain encoded by exons 2-13 of the Galphas gene. Here, we have studied the signal transduction properties of XLalphas...
  11. ncbi Two imprinted gene mutations: three phenotypes
    B M Cattanach
    Medical Research Council, Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 9:2263-73. 2000
    ..A hypothesis to explain the phenotypes associated with the three genotypes based on the NESP:/NESPAS: sense/antisense and GNASXL: transcripts in the GNAS: cluster is offered.
  12. pmc Two overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usage
    M Klemke
    Department of Neurobiology, Interdisciplinary Centre of Neuroscience, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    EMBO J 20:3849-60. 2001
    The >1 kb XL-exon of the rat XLalphas/Galphas gene encodes the 37 kDa XL-domain, the N-terminal half of the 78 kDa neuroendocrine-specific G-protein alpha-subunit XLalphas...
  13. ncbi Alternative non-coding splice variants of Nespas, an imprinted gene antisense to Nesp in the Gnas imprinting cluster
    Christine M Williamson
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, OX11 0RD, UK
    Mamm Genome 13:74-9. 2002
    ..Three of these in the order Nesp--Gnasxl--Gnas are transcribed in the sense direction with Nesp having maternal-specific expression, Gnasxl having paternal ..
  14. ncbi Receptor-mediated adenylyl cyclase activation through XLalpha(s), the extra-large variant of the stimulatory G protein alpha-subunit
    Murat Bastepe
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Mol Endocrinol 16:1912-9. 2002
    XLalpha(s), the large variant of the stimulatory G protein alpha subunit (Gsalpha), is derived from GNAS1 through the use of an alternative first exon and promoter...
  15. ncbi The imprinted oedematous-small mutation on mouse chromosome 2 identifies new roles for Gnas and Gnasxl in development
    Judith A Skinner
    Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire OX11 ORD, UK
    Genomics 80:373-5. 2002
    ..The maternally expressed mutant Gnas transcript is the candidate for Oed and the paternally expressed mutant Gnasxl transcript is the candidate for Sml...
  16. pmc XLalphas, the extra-long form of the alpha-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex
    Joel Abramowitz
    Transmembrane Signal Transduction Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 101:8366-71. 2004
    ..XXLb proteins are likely to be found as stable dimers with AlexX. The N-terminally longer proteins may play regulatory roles...
  17. ncbi The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding
    Antonius Plagge
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, CB2 4AT, UK
    Nat Genet 36:818-26. 2004
    ..We disrupted a paternally expressed transcript at the Gnas locus, Gnasxl, which encodes the unusual Gs alpha isoform XL alpha s...
  18. ncbi A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas
    Christine M Williamson
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, UK
    Nat Genet 36:894-9. 2004
    ..cluster on distal mouse chromosome 2, one at exon 1A upstream of Gnas itself and one covering the promoters for Gnasxl and the antisense Nespas (ref. 8)...
  19. pmc Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo
    Murat Bastepe
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 101:14794-9. 2004
    ..The alpha subunit of Gs (Gsalpha) is encoded by GNAS (Gnas in mice), and heterozygous Gsalpha inactivating mutations lead to Albright hereditary osteodystrophy...
  20. ncbi Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation
    Akio Sakamoto
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Bone Miner Res 20:663-71. 2005
    ..These results show that G(s)alpha negatively regulates chondrocyte differentiation and is the critical signaling mediator of the PTH/PTH-rP receptor in growth plate chondrocytes...
  21. pmc Imprinted Nesp55 influences behavioral reactivity to novel environments
    Antonius Plagge
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Mol Cell Biol 25:3019-26. 2005
    ..Of these, the Nesp transcript, expressed exclusively from the maternal allele, codes for neuroendocrine secretory protein 55 (Nesp55), a chromogranin-like polypeptide associated with the constitutive secretory pathway but ..
  22. pmc Alternative Gnas gene products have opposite effects on glucose and lipid metabolism
    Min Chen
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:7386-91. 2005
    ..extralarge G(s)alpha (XLalphas), a paternally expressed G(s)alpha isoform; and neuroendocrine-specific protein (NESP55), a maternally expressed chromogranin-like protein...
  23. ncbi A mouse model of albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene
    Emily L Germain-Lee
    Division of Pediatric Endocrinology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Park Building, Suite 211, 600 North Wolfe Street, Baltimore, Maryland 21287 2520, USA
    Endocrinology 146:4697-709. 2005
    ..is caused by heterozygous inactivating mutations in GNAS, a gene that encodes not only the alpha-chain of Gs (Galphas), but also NESP55 and XLalphas through use of alternative first exons...
  24. pmc Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency
    Min Chen
    Metabolic Diseases Branch, NIDDK, NIH, Bethesda, Maryland 20892 1752, USA
    J Clin Invest 115:3217-27. 2005
    ..Our results define novel roles for hepatic G(s)-signaling pathways in glucose and lipid regulation, which may prove useful in designing new therapeutic targets for diabetes and obesity...
  25. ncbi Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster
    Christine M Williamson
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
    Nat Genet 38:350-5. 2006
    ..The group of imprinted transcripts in the mouse Gnas cluster (Nesp, Nespas, Gnasxl, Exon 1A and Gnas) provides a model for analyzing the mechanisms of imprint regulation...
  26. pmc The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice
    Tao Xie
    Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:18989-99. 2006
    ..XLalphas knock-out mice (Gnasxl(m+/p-)) have poor suckling and perinatal lethality, implicating XLalphas as critical for postnatal feeding...
  27. ncbi Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsalpha deletion caused by a renin promoter-Cre transgene
    Hayo Castrop
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Cell Tissue Res 330:487-501. 2007
    ..Gnas encodes the alpha-subunit of the stimulatory G protein (Gs alpha)...
  28. pmc Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region
    Tao Xie
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Building 10, Room 8C101, Bethesda, Maryland 20892 1752, USA
    Endocrinology 149:2443-50. 2008
    ....
  29. pmc Transcription is required for establishment of germline methylation marks at imprinted genes
    Mita Chotalia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, United Kingdom
    Genes Dev 23:105-17. 2009
    ..We show that at the Gnas locus, truncating transcripts from the furthest upstream Nesp promoter disrupts oocyte-derived methylation of the differentially methylated regions (DMRs)...
  30. doi A missense mutation in the non-neural G-protein alpha-subunit isoforms modulates susceptibility to obesity
    M L Kelly
    MRC Harwell, Metabolism and Inflammation Section, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, UK
    Int J Obes (Lond) 33:507-18. 2009
    The Gnas transcription unit located within an imprinting region encodes several proteins, including the G-protein alpha-subunit, Gsalpha, its isoform XLalphas and their variant truncated neural forms GsalphaN1 and XLN1...
  31. pmc Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation
    Min Chen
    Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 9:548-55. 2009
    ....
  32. pmc GNAS haploinsufficiency leads to subcutaneous tumor formation with collagen and elastin deposition and calcification
    Akio Sakamoto
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Endocr Res 34:1-9. 2009
    ..We now describe the development of fibrous tumors in mice with heterozygous disruption of the Gnas gene, which encodes G(s)alpha and other gene products.
  33. pmc G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis
    Min Chen
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 11:320-30. 2010
    ..In normal mice, high-fat diet raised sympathetic nerve activity in muscle, but not in BAT. Our results show that cold- and diet-induced thermogenesis may occur in separate tissues, especially when BAT function is impaired...
  34. pmc Targeted deletion of the Nesp55 DMR defines another Gnas imprinting control region and provides a mouse model of autosomal dominant PHP-Ib
    Leopold F Fröhlich
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:9275-80. 2010
    ..We previously identified two almost identical GNAS microdeletions extending from exon NESP55 to antisense (AS) exon 3 (delNESP55/delAS3-4)...
  35. pmc Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo
    Zun Liu
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 50 Blossom Street, Thier 10, Boston, Massachusetts 02114, USA
    Endocrinology 152:1222-33. 2011
    ..222 ± 41 pg/ml; P < 0.05). After crossing the rptXLαs mice to mice with ablation of maternal Gnas exon 1 (E1(m-/+)), male offspring carrying both the XLαs transgene and maternal Gnas exon 1 ablation (rptXLαs/E1(..
  36. pmc Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster
    Christine M Williamson
    Medical Research Council Mammalian Genetics Unit, Harwell Science and Innovation Campus, Harwell, United Kingdom
    PLoS Genet 7:e1001347. 2011
    ..2, Nespas is a paternally expressed macroRNA that arises from an imprinting control region and runs antisense to Nesp, a paternally repressed protein coding transcript...
  37. pmc Heterotopic ossifications in a mouse model of albright hereditary osteodystrophy
    David L Huso
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e21755. 2011
    ..mediate their actions through G protein-coupled receptors, a condition termed pseudohypoparathyroidism type 1a (PHP1a)...
  38. pmc Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
    JOY Y WU
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA
    J Clin Invest 121:3492-504. 2011
    ....
  39. pmc Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification
    Robert J Pignolo
    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Bone Miner Res 26:2647-55. 2011
    ..By contrast, the GNAS proteins G(s)α, XLαs, and NESP55 are detected in adipocytes and in adipose stroma...
  40. pmc Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling
    Zun Liu
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:38558-69. 2011
    Murine models indicate that Gαs and its extra-long variant XLαs, both of which are derived from GNAS, markedly differ regarding their cellular actions, but these differences are unknown...
  41. pmc Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia
    Jean B Regard
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:20101-6. 2011
    ..Our data suggest that activated Gα proteins are playing physiologically significant roles during both skeletal development and disease by modulating Wnt/β-catenin signaling strength...
  42. pmc New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism but not in suckling
    Sally A Eaton
    Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
    Mol Cell Biol 32:1017-29. 2012
    ..because suckling is unimpaired, unlike mutants in which the expression of all the known paternally expressed Gnasxl proteins (XLαs, XLN1 and ALEX) is compromised...
  43. pmc Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice
    Stefan O Krechowec
    Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 7:e29753. 2012
    The alternatively spliced trimeric G-protein subunit XLαs, which is involved in cAMP signalling, is encoded by the Gnasxl transcript of the imprinted Gnas locus...
  44. pmc Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations
    Min Chen
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland 20892 1752, USA
    Endocrinology 153:4256-65. 2012
    ....
  45. pmc Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus
    Candice Coombes
    Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Mol Cell Biol 23:5475-88. 2003
    ..is subject to tissue-specific imprinted expression, Nesp is expressed only from the maternal allele, and Gnasxl is expressed only from the paternal allele. The mechanisms controlling these expression patterns are not known...
  46. ncbi Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone
    Akio Sakamoto
    Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:21369-75. 2005
    ..Osteoblast-specific G(s)alpha deficiency leads to reduced bone turnover...
  47. pmc Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit
    Jie Liu
    Metabolic Diseases Branch and Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:5513-8. 2005
    Gnas is a complex gene with multiple imprinted promoters. The upstream Nesp and Nespas/Gnasxl promoters are paternally and maternally methylated, respectively...
  48. pmc Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
    Yutong Sun
    Department of Physiology, Weill Medical College, Cornell University, New York, NY 10021, USA
    EMBO J 26:53-64. 2007
    ..This new dosage-dependent switch of signaling modes of GPCRs has significant implications for GPCR intrinsic properties and desensitization...
  49. pmc Gsalpha signalling suppresses PPARgamma2 generation and inhibits 3T3L1 adipogenesis
    Lei Zhang
    School of Medicine, Centre for Endocrine and Diabetes Sciences, Cardiff University, Heath Park, Cardiff, UK
    J Endocrinol 202:207-15. 2009
    ..speculated that Gbetagamma signalling may be inhibitory but failed to induce adipogenesis using activated Gsalpha (gsp*). Inhibition of phosphodiesterases did not promote adipogenesis in TSHR* or gsp* populations...
  50. pmc The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins
    Sonia Sebastian
    William Harvey Heart Centre, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 305:R435-42. 2013
    ..We conclude that Gαs- and Gαi2-mediated signaling in the sinoatrial node is important in the reciprocal regulation of heart rate through the autonomic nervous system. ..
  51. doi Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons
    Ai Nakashima
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113 0032, Japan Department of Brain Function, School of Medical Science, University of Fukui, Fukui 910 1193, Japan
    Cell 154:1314-25. 2013
    ..We conclude that the equilibrium of conformational transitions set by each OR is the major determinant of expression levels of A-P-targeting molecules...
  52. pmc Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification
    Jean B Regard
    1 National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Med 19:1505-12. 2013
    ..In progressive osseous heteroplasia, a human disease caused by null mutations in GNAS, which encodes Gαs, Hedgehog signaling is upregulated in ectopic osteoblasts and progenitor cells...
  53. pmc Loss of Gsα early in the osteoblast lineage favors adipogenic differentiation of mesenchymal progenitors and committed osteoblast precursors
    Partha Sinha
    Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA
    J Bone Miner Res 29:2414-26. 2014
    ..These findings have clinical implications for developing therapeutic approaches to direct the commitment of mesenchymal progenitors into the osteoblast lineage...
  54. pmc The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma
    Xuelian He
    1 Department of Forensic Medicine, State Key Laboratory of Biotherapy Collaborative Innovation Center for Biotherapy, School of Preclinical and Forensic Medicine, West China Second Hospital, Sichuan University, Chengdu, China 2 Department of Pediatrics, Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Nat Med 20:1035-42. 2014
    ..Herein, we identify GNAS, encoding the G protein Gαs, as a potent tumor suppressor gene that, when expressed at low levels, defines a ..
  55. doi Neuromodulatory effect of Gαs- or Gαq-coupled G-protein-coupled receptor on NMDA receptor selectively activates the NMDA receptor/Ca2+/calcineurin/cAMP response element-binding protein-regulated transcriptional coactivator 1 pathway to effectively induce
    Mamoru Fukuchi
    Department of Biological Chemistry, Graduate School of Medicine and Pharmaceutical Sciences
    J Neurosci 35:5606-24. 2015
    ....
  56. pmc Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis
    Ramiro Iglesias-Bartolomé
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Cell Biol 17:793-803. 2015
    Genomic alterations in GNAS, the gene coding for the Gαs heterotrimeric G protein, are associated with a large number of human diseases...
  57. ncbi Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor
    Y Luo
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:10685-8. 1999
    ..These findings define a novel nucleotide exchange function for Pcp2 and suggest that the interaction between Pcp2 and Galphao is important to Purkinje cell function...
  58. doi Umami taste receptor functions as an amino acid sensor via Gαs subunit in N1E-115 neuroblastoma cells
    Yoshikage Muroi
    Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro Hokkaido, 080 8555, Japan
    J Cell Biochem 113:1654-62. 2012
    ..We concluded that Tas1r1 + 3 functions as an amino acid sensor and activates the intracellular signaling pathway through the Gαs subunit in N1E-115 cells...
  59. pmc Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets
    Xiangli Li
    Department of Medicine, UCSD, La Jolla, California 92093 0663, USA
    J Clin Invest 122:963-73. 2012
    ..we engineered mice in which the stimulatory Gα subunit of Gs (Gαs) could be deleted in T cells using CD4-Cre (Gnas(ΔCD4)). Gnas(ΔCD4) CD4(+) T cells had reduced cAMP accumulation and Ca2(+) influx...
  60. pmc A mouse model for osseous heteroplasia
    Michael T Cheeseman
    Medical Research Council Mammalian Genetics Unit, Medical Research Council Harwell, Oxfordshire, UK
    PLoS ONE 7:e51835. 2012
    b>GNAS/Gnas encodes G(s)α that is mainly biallelically expressed but shows imprinted expression in some tissues...
  61. ncbi Selective amplification and partial sequencing of cDNAs encoding G protein alpha subunits from cochlear tissues
    M Tachibana
    Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892
    Hear Res 62:82-8. 1992
    ..Possible functions in the cochlea of putative G proteins with alpha-subunits partly encoded by these cDNA clones are briefly discussed and future studies are suggested...
  62. ncbi Mapping of the structural gene for S-adenosyl homocysteine hydrolase to mouse chromosome 2, and related sequences to chromosomes 8 and X
    A Pilz
    Department of Genetics and Biometry, University College London, UK
    Mamm Genome 3:633-6. 1992
    ..One, Ahcy-rs1, was mapped to Chr 8 in the BXH recombinant inbred strains, and the other, Ahcy-rs2, shows a pattern of inheritance consistent with X-linkage...
  63. ncbi Mapping of the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase (GNAS1) to 20q13.2----q13.3 in human by in situ hybridization
    M A Levine
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Genomics 11:478-9. 1991
  64. ncbi Golf: an olfactory neuron specific-G protein involved in odorant signal transduction
    D T Jones
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetic Johns Hopkins School of Medicine, Baltimore, MD 21205
    Science 244:790-5. 1989
    ..Golf alpha shares extensive amino acid identity (88 percent) with the stimulatory G protein, Gs alpha. The expression of Golf alpha in S49 cyc- kin- cells, a line deficient in endogenous stimulatory G proteins, ..
  65. ncbi Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma
    T Rall
    Merrell Dow Research Institute, Strasbourg, France
    FEBS Lett 224:365-71. 1987
    ..A single nucleotide transversion was found that coded for a proline rather than an arginine at residue 389. The results indicate a domain of the alpha-subunit of Gs that specifically interacts with hormone receptors...
  66. pmc Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human
    C Blatt
    Weizmann Institute, Rehovoth, Israel
    Proc Natl Acad Sci U S A 85:7642-6. 1988
    ..on chromosomes 3 and 1; GNAI1, GNAI2, and GNAI3 were assigned to chromosomes 7, 3, and 1, respectively; GNAZ and GNAS were found on chromosomes 22 and 20...
  67. pmc Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain
    H Itoh
    Proc Natl Acad Sci U S A 83:3776-80. 1986
    ..cDNAs encoding the complete sequences of Gi alpha and Gs alpha were thus obtained...
  68. ncbi Chromosomal localization, embryonic expression, and imprinting tests for Bmp7 on distal mouse chromosome 2
    P C Marker
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305 5427, USA
    Genomics 28:576-80. 1995
    ..Both embryonic expression patterns and the human chromosomal sublocalization inferred from its mouse location make Bmp7 a candidate for the gene affected in some patients with Holt-Oram syndrome...
  69. ncbi A high-resolution linkage map of the lethal spotting locus: a mouse model for Hirschsprung disease
    W J Pavan
    Laboratory for Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892
    Mamm Genome 6:1-7. 1995
    ..Three genes, endothelin-3 (Edn3), guanine nucleotide-binding protein alpha-stimulating polypeptide 1 (Gnas), and phosphoenolpyruvate carboxykinase (Pck1) were assessed as candidates for the ls mutation...
  70. ncbi Linkage mapping around the ragged (Ra) and wasted (wst) loci on distal mouse chromosome 2
    C Abbott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
    Genomics 20:94-8. 1994
    ..The results show that Ra maps very close to D2Mit74 and Acra-4, with no recombinants in 165 mice, whereas wst maps 3 cM distal to the most telomeric molecular marker on mouse chromosome 2, Acra-4...
  71. ncbi Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe)
    N A Jenkins
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Genomics 28:333-6. 1995
    ..Here, we show that Cebpb maps to mouse chromosome 2, Cebpd to chromosome 16, and Cebpe to chromosome 14. The assignment of Cebpd to chromosome 16 identifies a new region of homology between mouse chromosome 16 and human chromosome 8...
  72. ncbi Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach
    L Rambhatla
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Reprod Dev 41:314-24. 1995
    ..One alpha subunit mRNA increased in abundance at the early blastocyst stage. The possible significance of these alterations in G protein mRNA abundance to embryonic development is discussed...
  73. ncbi Phospholipid transfer protein maps to distal mouse chromosome 2
    R C LeBoeuf
    Department of Medicine, University of Washington, Seattle, Washington, 98195, USA
    Genomics 34:259-60. 1996
  74. ncbi Glomerular-specific imprinting of the mouse gsalpha gene: how does this relate to hormone resistance in albright hereditary osteodystrophy?
    C M Williamson
    Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxfordshire, OX11 ORD, United Kingdom
    Genomics 36:280-7. 1996
    ..Its human homologue (GNAS1) appears, from clinical and biochemical studies of patients with Albright hereditary osteodystrophy, to be ..
  75. ncbi The isolation and mapping of PCR markers specific to mouse Chromosome 2
    S Malas
    Department of Genetics and Biometry, University College London, UK
    Mamm Genome 7:145-8. 1996
  76. ncbi Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene
    C Luo
    Division of Cellular and Molecular Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Gene 180:29-36. 1996
    ..Therefore, the wasted phenotype is not due to a defect in the expression or early regulation of the NFAT1 protein...
  77. pmc The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 137:685-701. 1997
    ..Together, these results reveal remarkable diversity in BL composition and complexity in BL development...
  78. ncbi Chromosome localization of two new mammalian kinases related to yeast and fly chromosome segregation-regulators
    G Gopalan
    Mammalian Genetics Laboratory, NCI Frederick Research and Development Center, Maryland 21702, USA
    Mamm Genome 9:86-7. 1998
  79. ncbi Gs alpha knockouts in mice and man
    L S Weinstein
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Rinsho Byori 47:425-9. 1999
  80. ncbi BRK/Sik expression in the gastrointestinal tract and in colon tumors
    X Llor
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago 60607, USA
    Clin Cancer Res 5:1767-77. 1999
    ..The BRK tyrosine kinase appears to play a role in signal transduction in the normal gastrointestinal tract, and its overexpression may be linked to the development of a variety of epithelial tumors...
  81. ncbi BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary
    Debra E Bramblett
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genomics 79:402-12. 2002
    ..Together, these data suggest that BHLHB4 may modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types...
  82. ncbi Targeted expression of activated Q227L G(alpha)(s) in vivo
    Xi Ping Huang
    Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Program, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Am J Physiol Cell Physiol 283:C386-95. 2002
    ....
  83. ncbi Erythrocyte G protein-coupled receptor signaling in malarial infection
    Travis Harrison
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 Chicago Avenue, Chicago, IL 60611, USA
    Science 301:1734-6. 2003
    ..signaling via the erythrocyte beta2-adrenergic receptor and heterotrimeric guanine nucleotide-binding protein (Galphas) regulated the entry of the human malaria parasite Plasmodium falciparum...
  84. ncbi Identification of PSD-95 palmitoylating enzymes
    Masaki Fukata
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Neuron 44:987-96. 2004
    ..This study suggests that P-PATs regulate synaptic function through PSD-95 palmitoylation...
  85. ncbi Coding GNAS mutations leading to hormone resistance impair in vitro agonist- and cholera toxin-induced adenosine cyclic 3',5'-monophosphate formation mediated by human XLalphas
    Agnes Linglart
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Endocrinology 147:2253-62. 2006
    Most loss of function mutations of GNAS identified in different forms of pseudohypoparathyroidism disrupt not only the stimulatory G protein alpha-subunit (Gsalpha), but also its paternally expressed variant, XLalphas...
  86. ncbi Odorant receptor-derived cAMP signals direct axonal targeting
    Takeshi Imai
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113 0032, Japan
    Science 314:657-61. 2006
    ..Thus, it is the OR-derived cAMP signals, rather than direct action of OR molecules, that determine the target destinations of OSNs...
  87. pmc YY1 as a controlling factor for the Peg3 and Gnas imprinted domains
    Jeong Do Kim
    Department of Biological Sciences, Center for BioModular Multi Scale Systems, Louisiana State University, Baton Rouge, LA 70803, USA
    Genomics 89:262-9. 2007
    ..also observed for the imprinted genes of the Gnas domain: up-regulation of Nespas and down-regulation of Nesp and Gnasxl. YY1 knockdown also resulted in changes in the expression levels of Xist and Snrpn...
  88. pmc Chronically increased Gsalpha signaling disrupts associative and spatial learning
    Rusiko Bourtchouladze
    Center for Neurobiology and Behavior and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Learn Mem 13:745-52. 2006
    ..The learning deficits observed in these transgenic mice suggest that associative and spatial learning requires regulated Gsalpha protein signaling, much as does olfactory learning in Drosophila...
  89. pmc An unmethylated 3' promoter-proximal region is required for efficient transcription initiation
    Ruth Appanah
    Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Genet 3:e27. 2007
    ..This model provides a biochemical explanation for the typical positioning of TSSs well upstream of the 3' end of the CpG islands in which they are embedded...
  90. doi Physiological dysfunctions associated with mutations of the imprinted Gnas locus
    Stefan Krechowec
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom
    Physiology (Bethesda) 23:221-9. 2008
    The ubiquitous Galphas-subunit of the trimeric, stimulatory G-protein plays a central role in receptor-mediated signal transduction, coupling receptor activation with the production of cAMP...
  91. pmc Removal of the N-terminal extension of cardiac troponin I as a functional compensation for impaired myocardial beta-adrenergic signaling
    Han Zhong Feng
    Section of Molecular Cardiology, Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
    J Biol Chem 283:33384-93. 2008
    ..These data indicate that the up-regulation of cTnI-ND may partially compensate for the cardiac inefficiency in impaired beta-adrenergic signaling...
  92. pmc Chronic Galphas signaling in the striatum increases anxiety-related behaviors independent of developmental effects
    Christopher Favilla
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:13952-6. 2008
    ..b>Galphas, the G-protein which stimulates adenylyl cyclase and L-type voltage-gated calcium channels, may be one ..
  93. pmc Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathway
    Björn Neubauer
    Department of Physiology, Universitat Regensburg, Regensburg, Germany
    Am J Physiol Renal Physiol 296:F1006-12. 2009
    ....
  94. pmc Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow
    Gregor B Adams
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:103-7. 2009
    ..Galpha(s) governs specific aspects of HSPC localization under physiological conditions in vivo and may be pharmacologically targeted to improve transplantation efficiency...
  95. pmc CK2 negatively regulates Galphas signaling
    Heike Rebholz
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:14096-101. 2009
    ..Thus CK2 can inhibit G protein-coupled receptor action by enabling faster receptor internalization, possibly through a direct association with Galpha(s)...
  96. pmc Renal failure in mice with Gsalpha deletion in juxtaglomerular cells
    Limeng Chen
    National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Am J Nephrol 32:83-94. 2010
    ..In the present study we have determined the long-term effect on renal function, blood pressure, and renal pathology in this low renin and diuretic mouse model...
  97. pmc Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice
    Aime T Franco
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:1615-20. 2011
    ..Thyroid-specific deletion of the Gsα gene in LSL-Braf(V600E)/TPO-Cre/Gnas-E1(fl/fl) mice also resulted in an attenuated cancer phenotype, indicating that the cooperation of TshR with ..
  98. pmc Absence of the glucagon-like peptide-1 receptor does not affect the metabolic phenotype of mice with liver-specific G(s)α deficiency
    Min Chen
    Metabolic Diseases Branch, Building 10 Room 8C101, National Institute for Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1752, USA
    Endocrinology 152:3343-50. 2011
    ....
  99. pmc Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse
    M Strathmann
    Division of Biology, California Institute of Technology, Pasadena 91125
    Proc Natl Acad Sci U S A 86:7407-9. 1989
    ..In addition, we found sequences corresponding to five newly discovered alpha subunits. Our results suggest that the complexity of the G protein family is much greater than previously suspected...
  100. pmc Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains
    K A Sullivan
    Proc Natl Acad Sci U S A 83:6687-91. 1986
    ..Further comparison of the alpha-chain sequences suggests additional regions that may contribute to interactions with beta gamma subunits and the receptor and effector components of different signal transduction systems...
  101. ncbi 71.67 T lymphocyte activation is accompanied by the down-regulation of three G alpha genes
    B Rock
    Department of Dermatology, Emory University, Atlanta, Georgia 30322, USA
    Cell Immunol 164:316-21. 1995
    ..These findings suggest that an important element in signal transduction through these G proteins in lymphocytes may include regulation of G alpha mRNA steady-state levels...

Research Grants3

  1. Circulating osteogenic cells in aging and disease
    Robert Pignolo; Fiscal Year: 2007
    ..LONG-TERM OBJECTIVES: To define the role of BdACs as osteogenic cells with potential for use in diagnostic testing, cell replacement therapy, or as a target population for gene therapy. ..
  2. BHLH FACTOR IN DIABETES & PANCREAS DEVELOPMENT
    DEBRA BRAMBLETT; Fiscal Year: 2003
    ..The BETA4 knockout will be a mouse model system for the study of aspects of pancreas development and possibly pancreatic disease. ..
  3. Regulation of Meiotic Arrest in Oocytes by G-Proteins
    LISA MEHLMANN; Fiscal Year: 2004
    ..Understanding how the oocyte cell cycle is regulated within the follicle may find applications to practical problems including assisted reproductive techniques, contraception, and infertility. ..