Genomes and Genes
Gene Symbol: Gli3
Description: GLI-Kruppel family member GLI3
Alias: AI854843, AU023367, Bph, GLI3-190, GLI3FL, Pdn, add, transcriptional activator GLI3, GLI3 form of 190 kDa, GLI3 full length protein, anterior digit pattern deformity, brachyphalangy, extra toes, polydactyly Nagoya, zinc finger protein GLI3
Publications169 found, 100 shown here
- The graded response to Sonic Hedgehog depends on cilia architectureTamara Caspary
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Dev Cell 12:767-78. 2007..Double mutant analysis indicates that Gli3 repressor activity is normal in hnn embryos, but Gli activators are constitutively active at low levels...
- Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conservedMiao Hsueh Chen
Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94158, USA
Genes Dev 23:1910-28. 2009..Taken together, these studies delineate important aspects of cilium-dependent and cilium-independent Hh signal transduction and provide significant mechanistic insight into Hh signaling in diverse species...
- The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteinsEric W Humke
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Genes Dev 24:670-82. 2010..We show that the interaction between Gli3 and Suppressor of Fused (Sufu) regulates the formation of either repressor or activator forms of Gli3...
- Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limbTomoko Sagai
Mammalian Genetics Laboratory, National Institute of Genetics, Yata 1111 Mishima, Shizuoka ken 411 8540, Japan
Development 132:797-803. 2005..These results suggest that the conserved intronic sequence evolved in a common ancestor of fishes and tetrapods to control fin and limb development...
- Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signalingKarel F Liem
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
Proc Natl Acad Sci U S A 106:13377-82. 2009..We conclude that Kif7 is a core regulator of Shh signaling that may also act as a ciliary motor...
- Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limbB Wang
Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cell 100:423-34. 2000..We demonstrate that PKA-dependent processing of vertebrate Gli3 in developing limb similarly generates a potent repressor in a manner antagonized by apparent long-range signaling ..
- All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3C Brian Bai
Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Dev Cell 6:103-15. 2004..The full range of Gli activity and its dependence on Hh have not been determined, although the Gli2 activator and Gli3 repressor have been implicated...
- Hedgehog signalling in the mouse requires intraflagellar transport proteinsDanwei Huangfu
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
Nature 426:83-7. 2003..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction...
- Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterningSohyun Ahn
Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York, NY 10016, USA
Cell 118:505-16. 2004..Finally, by fate mapping Shh-responding cells in Gli2 and Gli3 mutant limbs, we demonstrate that a specific level of positive Hh signaling is not required to specify digit ..
- Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradationXiaohui Wen
Genentech, South San Francisco, CA 94080, USA
Mol Cell Biol 30:1910-22. 2010..By generating antibodies capable of detecting endogenous pathway transcription factors Gli2 and Gli3, we monitored their kinetics of accumulation in cilia upon Hh stimulation...
- Ftm is a novel basal body protein of cilia involved in Shh signallingJeanette Vierkotten
Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
Development 134:2569-77. 2007..The loss of Ftm affects the ratio of Gli3 activator to Gli3 repressor, suggesting an involvement of Ftm in Shh signalling...
- Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1P M Lewis
Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Cell 105:599-612. 2001..Thus, cholesterol modification is essential for the normal range of signaling. It also appears to be necessary for appropriate modulation of signaling by the Shh receptor, Ptc1...
- Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb budKazushi Aoto
Molecular Neuropathology Group, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Dev Biol 251:320-32. 2002The zinc finger transcription factor GLI3 is considered a repressor of vertebrate Hedgehog (Hh) signaling...
- Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant miceQ Ding
Program in Developmental Biology and Division of Endocrinology, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Development 125:2533-43. 1998..Our results imply that Gli2 is required to mediate high level but not low level Shh activity and show that the development of motor neurons can occur in the absence of floor plate induction...
- Cilia and Hedgehog responsiveness in the mouseDanwei Huangfu
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:11325-30. 2005..patterning phenotype than Smo mutants, because Ift172, but not Smo, is required for proteolytic processing of Gli3 to its repressor form...
- Loss of the Tg737 protein results in skeletal patterning defectsQihong Zhang
The University of Alabama at Birmingham, Department of Cell Biology, Birmingham, Alabama 35294, USA
Dev Dyn 227:78-90. 2003..Collectively, the data argue for a dosage effect of Tg737 on the limb phenotypes and that the polydactyly is independent of Shh misexpression...
- Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation developmentC C Hui
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Dev Biol 162:402-13. 1994..Consistent with this hypothesis, a naturally occurring Gli-3 mutation, the mouse extra-toes mutant; shows defects in both mesoderm- and ectoderm-derived tissues...
- Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiationLydia Koziel
Max Planck Institute for Molecular Genetics, Berlin, Germany
Development 132:5249-60. 2005..signal is translated in the different target tissues, we analyzed the role of the zinc-finger transcription factor Gli3, which acts downstream of hedgehog signals in other organs...
- Gli3-deficient mice exhibit cleft palate associated with abnormal tongue developmentXi Huang
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Dev Dyn 237:3079-87. 2008..We observed a high incidence of palate clefting in mice deficient in Gli3, known for its role as a repressor in the absence of Shh signaling...
- A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterningMadelen Lek
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
Development 137:4051-60. 2010..These data establish that dynamic, non-graded changes in responding cells are essential for Shh morphogen interpretation, and provide a rationale to explain mechanistically the phenomenon of cellular memory of morphogen exposure...
- A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalusJoshua M Friedland-Little
Department of Pediatrics, The University of Chicago, 900 East 57th Street, Chicago, IL 60637, USA
Hum Mol Genet 20:3725-37. 2011..We propose a model in which mutation of Ift172 results in a specific class of abnormal cilia, causing disrupted Hh signaling while maintaining L-R axis determination, and resulting in the VACTERL-H phenotype...
- Fuz regulates craniofacial development through tissue specific responses to signaling factorsZichao Zhang
Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas, United States of America
PLoS ONE 6:e24608. 2011..These data demonstrate a new model for coordination of Hh and Wnt signaling and reveal a Fuz-dependent negative feedback loop controlling Wnt/β-catenin signaling...
- A primary cilia-dependent etiology for midline facial disordersSamantha A Brugmann
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
Hum Mol Genet 19:1577-92. 2010..which is accompanied by broader expression domains of Gli1, Ptc and Shh, and reduced expression domains of Gli3. Furthermore, broader domains of Gli1 expression correspond to areas of enhanced neural crest cell proliferation in ..
- A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexesHanna Tukachinsky
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
J Cell Biol 191:415-28. 2010..Our results support a simple mechanism in which Hh signals at vertebrate cilia cause dissociation of inactive SuFu-Gli complexes, a process inhibited by PKA...
- Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathwayVictoria L Patterson
Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxon, UK
Hum Mol Genet 18:1719-39. 2009..downstream of Shh and Smoothened (Smo) in neural tube patterning and exhibits a genetic interaction with Gli3 in limb development...
- Extra-toes: anew mutant gene causing multiple abnormalities in the mouseD R Johnson
J Embryol Exp Morphol 17:543-81. 1967
- Unique functions of Sonic hedgehog signaling during external genitalia developmentR Haraguchi
Center for Animal Resources and Development CARD and Graduate School of Molecular and Genomic Pharmacy, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
Development 128:4241-50. 2001..These results suggest a dual mode of Shh function, first by the regulation of initiating GT outgrowth, and second, by subsequent GT differentiation...
- High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletionThomas M Maynard
Department of Cell and Molecular Physiology, UNC Neuroscience Center, CB 7545, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mamm Genome 13:58-61. 2002
- Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesisKazushi Aoto
Molecular Neuropathology Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Dev Biol 327:106-20. 2009..These findings provide new insight into the mechanism underlying HPE pathoetiology during dynamic brain and craniofacial morphogenesis...
- Evidence for the involvement of the Gli gene family in embryonic mouse lung developmentJ C Grindley
Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee, 37232 2175, USA
Dev Biol 188:337-48. 1997Murine Gli, Gli2, and Gli3 are zinc finger genes related to Drosophila cubitus interuptus, a component of the hedgehog signal transduction pathway...
- Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradationYong Pan
Weill Medical College of Cornell University, 1300 York Avenue, Room W404, New York, NY 10021, USA
Mol Cell Biol 26:3365-77. 2006Gli2 and Gli3 are the primary transcription factors that mediate Sonic hedgehog (Shh) signals in the mouse. Gli3 mainly acts as a transcriptional repressor, because the majority of full-length Gli3 protein is proteolytically processed...
- Shh dependent and independent maintenance of basal midbrainAriadna Perez-Balaguer
Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
Mech Dev 126:301-13. 2009..Based on our results and recently published data, we suggest the existence of a specific genetic pathway for the specification of the mesencephalic red nucleus. Foxa2 could be the candidate gene that might control this genetic pathway...
- A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitroH Sasaki
Laboratory of Developmental Biology, Osaka University, Suita, Japan
Development 124:1313-22. 1997..Gli expression is restricted to the ventral part, while Gli2 and Gli3 are expressed throughout the neural tube and dorsally, respectively...
- Polydactyly and ectopic ZPA formation in Alx-4 mutant miceS Qu
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Development 124:3999-4008. 1997..of other candidate regulators of anterior-posterior positional information in the limb bud, including HoxB8 and Gli3, is not altered in Alx-4 mutant embryos...
- Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and developmentR Mo
Program in Developmental Biology and Division of Endocrinology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Development 124:113-23. 1997..Interestingly, Gli2 and Gli3 (C.-c. Hui and A. L. Joyner (1993). Nature Genet...
- Sonic Hedgehog mediator Gli2 regulates bladder mesenchymal patterningWei Cheng
Division of Paediatric Surgery, Department of Paediatrics, Monash University, Melbourne, Australia
J Urol 180:1543-50. 2008..Current evidence suggests that Shh (R&D Systems) is an epithelial signal regulating bladder development, although the mechanism of the regulation is still unclear. We examined the regulation of bladder mesenchymal development...
- Primary cilia regulate Shh activity in the control of molar tooth numberAtsushi Ohazama
Department of Craniofacial Development, Dental Institute, King s College London, London SE1 9RT, UK
Development 136:897-903. 2009..Strikingly, the ectopic teeth adopt a size and shape characteristic of premolars, a tooth type that was lost in mice around 50-100 million years ago...
- Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterningAsa Kolterud
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
Gastroenterology 137:618-28. 2009..We profiled cellular Hedgehog response patterns from embryonic day 10.5 (E10.5) to adult in murine antrum, pyloric region, small intestine, and colon...
- Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud developmentAntonella Galli
Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
PLoS Genet 6:e1000901. 2010..studies indicate that Hand2 and Hoxd13 can efficiently transactivate gene expression via the ZRS, while the Gli3 repressor isoform interferes with this positive transcriptional regulation...
- Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouseH Masuya
Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Japan
Dev Biol 182:42-51. 1997..We studied the spatial and temporal pattern of expression of the Gli3 gene, which is affected in a loss-of-function type of mutation, Xt1...
- Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genesSanne Kuijper
Hubrecht Laboratory, The Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
Development 132:1601-10. 2005..We have studied the impact of Tbx15, Gli3, Alx4 and related genes on formation of the skeletal elements of the mouse shoulder and pelvic girdles...
- Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagusJ Motoyama
Programs in Developmental Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Nat Genet 20:54-7. 1998..In mice, three zinc-finger transcription factors, Gli1, Gli2 and Gli3, have been implicated in the transduction of Shh signal...
- Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formationAileen McDermott
Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
Development 132:345-57. 2005..We report that Gli genes are differentially expressed in the mouse somite. Gli2 and Gli3 are essential for Gli1 expression in somites, establishing Gli2 and Gli3 as primary mediators and Gli1 as a ..
- Unique and complimentary activities of the Gli transcription factors in Hedgehog signalingRobert J Lipinski
Molecular and Environmental Toxicology Center, Madison, WI 53705 222, USA
Exp Cell Res 312:1925-38. 2006..Gli2 loss-of-function was associated with diminished Shh-induced target gene expression, while Gli3 loss-of-function was associated with increased basal and Shh-induced target gene expression...
- FGF signalling generates ventral telencephalic cells independently of SHHGrigoriy Gutin
Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
Development 133:2937-46. 2006..however, has recently been questioned because loss of the Shh gene has little effect on ventral development if the Gli3 gene is also mutant. Consequently, another ventral determinant must exist...
- Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanismsElona Kolpakova-Hart
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
Dev Biol 309:273-84. 2007..We show that in Kif3a-deficient mesenchymal tissues both the repressor function of Gli3 transcription factor and the activation of the Shh transcriptional targets Ptch and Gli1 are compromised...
- Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb developmentD Buscher
Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Germany
Mech Dev 62:175-82. 1997..In the polydactyly mouse mutant extra toes (Xt), possessing a null mutation of Gli3, Shh is additionally expressed in the anterior region of the limb bud...
- Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1M Hynes
Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
Neuron 19:15-26. 1997..These findings demonstrate that GLI-1 can reproduce the cell patterning actions of Shh in the developing nervous system and provide support for the hypothesis that it is a mediator of the Shh signal in vertebrates...
- Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identityA Zuniga
EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Development 126:13-21. 1999..The unique and shared functions of Gli3 and formin in these determinative events were genetically analyzed using single and double homozygous Extra-toes (..
- Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1M T Lewis
Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA
Development 126:5181-93. 1999..Data demonstrate a critical mammary role for at least one component of the hedgehog signaling network and suggest that Ihh is the primary hedgehog gene active in the gland...
- Sonic hedgehog regulates growth and morphogenesis of the toothH R Dassule
Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
Development 127:4775-85. 2000..These studies demonstrate that Shh regulates growth and determines the shape of the tooth. However, Shh signaling is not essential for differentiation of ameloblasts or odontoblasts...
- Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog functionC Chiang
Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
Dev Biol 236:421-35. 2001..According to this model, the limb bud signaling centers, including the zone of polarizing activity (ZPA) acting through Shh, are required to elaborate upon the axial information provided by the native limb field prepattern...
- Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signalingPascal te Welscher
Department of Developmental Biology, Faculty of Biology, Utrecht University, 3584CH Utrecht, The Netherlands
Genes Dev 16:421-6. 2002..We show that the transcriptional repressor GLI3 restricts dHAND expression to posterior mesenchyme prior to activation of SHH signaling in mouse limb buds...
- Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesisAimee Zuniga
Department of Developmental Biology, Faculty of Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Mech Dev 114:51-9. 2002..Finally, Twist function, most likely by regulating FGF signalling, is required for cell survival as apoptotic cells are detected in posterior and distal limb bud mesenchyme...
- Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarizationAmel Gritli-Linde
Department of Oral Biochemistry, Sahlgrenska Academy at Goteborg University, Sweden
Development 129:5323-37. 2002..Furthermore, we provide evidence that Shh signaling between ameloblasts and the overlying stratum intermedium may involve subcellular localization of Patched 2 and Gli1 mRNAs, both of which are targets of Shh signaling in these cells...
- Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factorsAimin Liu
Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Mailstop 8322, Box 6511, Aurora, CO 80045, USA
Development 132:3103-11. 2005..domains of multiple posteriorly restricted genes are expanded anteriorly in the mutant limbs, similar to loss of Gli3 transcriptional repressor function...
- Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb developmentMaria Barna
Weill Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
Nature 436:277-81. 2005..Here we identify a genetic interaction between Gli3 (GLI-Kruppel family member 3) and Plzf (promyelocytic leukaemia zinc finger, also known as Zbtb16 and Zfp145), ..
- Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteinsJonathan T Eggenschwiler
Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
Dev Biol 290:1-12. 2006..Double mutant analysis indicates that the primary target of Rab23 is the Gli2 activator and that Rab23 and Gli3 repressor have additive effects on patterning...
- Netrin 1 regulates ventral tangential migration of guidepost neurons in the lateral olfactory tractTakahiko Kawasaki
Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, SOKENDAI, Yata 1111, Mishima 411 8540, Japan
Development 133:845-53. 2006..These results suggest that netrin 1 regulates the migration of lot cells and LOT projections, possibly by ensuring the correct distribution of these guidepost neurons...
- Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expressionTerence D Capellini
Department of Cell and Developmental Biology, Cornell University Weill Medical School, New York, NY 10021, USA
Development 133:2263-73. 2006....
- Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10Jozsef Zakany
Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
Dev Biol 306:883-93. 2007..Here, we describe antagonistic interactions between posterior Hoxd genes and Gli3, suggesting that the latter product protects the AER from the deleterious effect of the formers, and we present ..
- Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expressionRoberto Alvarez-Medina
Instituto de Biologia Molecular de Barcelona, CSIC, Parc Cientific de Barcelona, C Josep Samitier 1 5, Barcelona 08028, Spain
Development 135:237-47. 2008..Additionally, we show that Gli3 expression is controlled by Wnt activity...
- Analysis of early ventral telencephalic defects in mice lacking functional Gli3 proteinTian Yu
Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, Edinburgh, United Kingdom
J Comp Neurol 512:613-27. 2009The transcription factor Gli3 is expressed throughout developing telencephalon. Previous studies have focused on Gli3's role in dorsal telencephalon, which is greatly reduced in size in Gli3(Xt/Xt) mutants...
- Shh and Gli3 activities are required for timely generation of motor neuron progenitorsSaeock Oh
Department of Cell and Developmental Biology, Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Dev Biol 331:261-9. 2009..Genetic studies of Shh(-/-);Gli3(-/-) double mutants indicated that the inhibition of Gli3 repressor activity by Shh is sufficient for the ..
- Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt)A Vortkamp
Institut für Humangenetik der Philipps Universität, Marburg, FRG
Mamm Genome 3:461-3. 1992
- GLI3 zinc-finger gene interrupted by translocations in Greig syndrome familiesA Vortkamp
Institut fur Humangenetik, Philipps Universitat, Marburg, Germany
Nature 352:539-40. 1991..Here we show that two of the three translocations interup the GLI3 gene, a zinc-finger gene of the GLI-Krüppel family already localized to 7p13 (refs 5, 6)...
- Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous systemM P Matise
Developmental Genetics Program and Howard Hughes Medical Institute, and Department of Cell Biology and Physiology and Neuroscience, NYU Medical Center, New York, NY 10016, USA
Development 125:2759-70. 1998....
- Sonic hedgehog regulates branching morphogenesis in the mammalian lungC V Pepicelli
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Curr Biol 8:1083-6. 1998..In addition, the transcription of several mesenchymally expressed downstream targets of Shh is abolished. These results highlight the importance of epithelially derived Shh in regulating branching morphogenesis of the lung...
- Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3P Dai
Laboratory of Molecular Genetics, Tsukuba Life Science Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
J Biol Chem 274:8143-52. 1999..Here, we report distinct roles for GLI1 and GLI3 in Sonic hedgehog (Shh) signaling...
- Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J)S Tole
Department of Neurobiology, University of Chicago, Chicago, Illinois, 60637, USA
Dev Biol 217:254-65. 2000..patterning in the extra-toes (J) (Xt(J)) mouse mutant, which carries a deletion in the Gli family member Gli3. We report that dorsoventral patterning of the telencephalon is dramatically disrupted in the Xt(J) mutant...
- Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partnerD Simon-Chazottes
Unite de Genetique des Mammiferes, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Mamm Genome 11:614-21. 2000..Sufu binds with all three Gli proteins, with different affinities. This report, in conjunction with recent studies, points out the importance of Sufu in mouse embryonic development...
- Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathwayP C Kim
Programs in Infection, Immunity, Injury and Repair and Developmental Biology, Research Institute, The Hospital for Sick Children, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
J Pediatr Surg 36:381-4. 2001..The etiology, embryology, and pathogenesis of the VACTERL syndrome are not known. The authors report here new mouse models of VACTERL syndrome involving the Sonic hedgehog (Shh) signaling pathway...
- Progression of vertebrate limb development through SHH-mediated counteraction of GLI3Pascal te Welscher
Department of Developmental Biology, Faculty of Biology, Utrecht University, Padualaan 8, NL 3584 CH Utrecht, Netherlands
Science 298:827-30. 2002..Here, we report that the polydactyly of Gli3-deficient mice arises independently of SHH signaling...
- Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3Ping Dai
Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Ibaraki, Japan
Genes Dev 16:2843-8. 2002Transcription factor Glioblastoma-3 (Gli3) is cleaved in the anterior region of the limb bud to generate its repressor form...
- A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cordMark Wijgerde
Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
Genes Dev 16:2849-64. 2002..Comparative studies of Shh, Smo, and Gli3 single and compound mutants reveal that Hh signaling acts in part to specify neural cell identity by counteracting ..
- Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle developmentPleasantine Mill
Program in Developmental Biology, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
Genes Dev 17:282-94. 2003..Together, our results suggest that Shh-dependent Gli2 activation plays a critical role in epithelial homeostasis by promoting proliferation through the transcriptional control of cell cycle regulators...
- A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalonStefanie Kuschel
Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, D 40225 Dusseldorf, Germany
Dev Biol 260:484-95. 2003..we report on telencephalic development in Pdn mutant mice, which carry an integration of a retrotransposon in the Gli3 locus...
- Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene functionMarie Kmita
Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
Nature 435:1113-6. 2005..Accordingly, these mutant limbs may be reminiscent of an ancestral trunk extension, related to that proposed for arthropods...
- Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb developmentEdwina McGlinn
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
Mech Dev 122:1218-33. 2005From early in limb development the transcription factor Gli3 acts to define boundaries of gene expression along the anterior-posterior (AP) axis, establishing asymmetric patterns required to provide positional information...
- Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signalingRyuma Haraguchi
Center for Animal Resources and Development, CARD and Pharmaceutical Sciences, Kumamoto University, Honjo 2 2 1, Kumamoto, Japan
Development 134:525-33. 2007..Thus, the mesenchymal precursors for multiple urogenital structures derive from peri-cloacal mesenchyme and the coordination of urogenital organ formation from these precursors is orchestrated by Shh signals...
- Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner earJinwoong Bok
National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA
Development 134:1713-22. 2007..regulates inner ear development, we examined embryos with various combinations of mutant alleles for Shh, Gli2 and Gli3. Our study shows that Gli3 repressor (R) is required for patterning dorsal inner ear structures, whereas Gli ..
- Hoxd and Gli3 interactions modulate digit number in the amniote limbRushikesh Sheth
Departamento de Anatomia y Biologia Celular, Universidad de Cantabria, 39011, Santander, Spain
Dev Biol 310:430-41. 2007..SHH signaling prevents the processing of GLI3 into a short form that functions as a strong transcriptional repressor...
- Altered signaling pathway in the dysmorphogenesis of telencephalon in the Gli3 depressed mouse embryo, Pdn/PdnEtsuko Ueta
School of Health Science, Faculty of Medicine, Tottori University, Yonago, Japan
Congenit Anom (Kyoto) 48:74-80. 2008The responsible gene of genetic polydactyly/arhinencephaly mouse (Pdn/Pdn) is Gli3. Pdn/Pdn exhibits absence of the olfactory bulb, suggesting telencephalic dysmorphogenesis...
- The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during developmentSetsu Endoh-Yamagami
Department of Molecular Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Curr Biol 19:1320-6. 2009..We also demonstrate a requirement for Kif7 in the efficient localization of Gli3 to cilia in response to Hh and for the processing of Gli3 to its repressor form...
- Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouseWestley Heydeck
Department of Biology, Eberly College of Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Dev Dyn 238:3035-42. 2009..Fuz mutants also exhibit abnormal Hedgehog (Hh) signaling and inefficient proteolytic processing of Gli3. Finally, a significant decrease in cilia was found in Fuz homozygous mutants...
- Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular programShinichi Miyagawa
Institute of Molecular Embryology and Genetics, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 860 0811, Japan
Development 136:3969-78. 2009..Our results provide new insights into the integration of growth factor signaling in the appendicular developmental programs that regulate external genitalia development...
- GLI3 repressor controls functional development of the mouse ureterJason E Cain
Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
J Clin Invest 121:1199-206. 2011..and cell differentiation by promoting GLI-dependent transcriptional activation and by inhibiting the processing of GLI3 to a transcriptional repressor...
- The IFT-A complex regulates Shh signaling through cilia structure and membrane protein traffickingKarel F Liem
Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
J Cell Biol 197:789-800. 2012....
- The development of the eye in homozygotes of the mouse mutant Extra-toesT Franz
Abteilung fur Neuroanatomie, Universitäts Krankenhaus Eppendorf Hamburg, Federal Republic of Germany
Anat Embryol (Berl) 184:355-61. 1991....
- Brachyphalangy, an allele of extra-toes in the mouseD R Johnson
Genet Res 13:275-80. 1969
- A duplicated zone of polarizing activity in polydactylous mouse mutantsH Masuya
Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Japan
Genes Dev 9:1645-53. 1995..Here we report that a new mouse mutant, Recombination induced mutant 4 (Rim4), and two old mutants, Hemimelic extra toes (Hx) and Extra toes (Xt), exhibit mirror-image duplications of the skeletal pattern of the digits...
- The mouse mutant Polydactyly Nagoya (Pdn) defines a novel allele of the zinc finger gene Gli3T Schimmang
European Molecular Biology Laboratory, Heidelberg, Germany
Mamm Genome 5:384-6. 1994
- A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 geneC C Hui
Division of Molecular and Developmental Biology, Samuel Lunenfield Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Nat Genet 3:241-6. 1993..Recently, the human GLI3 gene has been proposed to be a candidate gene for GCPS...
- The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb developmentM Takahashi
The Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, CA 92037 1099, USA
Development 125:4417-25. 1998..Analysis of polydactylous mutants indicate that the interaction between Alx-4 and Shh is independent of Gli3, a negative regulator of Shh in the limb...
- Gli3 is required for Emx gene expression during dorsal telencephalon developmentT Theil
Institute for Molecular Biology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany thomas
Development 126:3561-71. 1999..Here, we report on forebrain development in the extra toes (Xt(J)) mouse mutant which carries a null mutation of the Gli3 gene...
- Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3Y Litingtung
Department of Cell Biology, Vanderbilt University Medical Center, B2120 MCN, Nashville, Tennessee 37232, USA
Nat Neurosci 3:979-85. 2000..Here we show that Gli3 represses ventral fates in a dose-dependent manner...
- Pallister-Hall syndrome phenotype in mice mutant for Gli3Jens Böse
Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitatsstrasse 1, 40225 Dusseldorf, Germany
Hum Mol Genet 11:1129-35. 2002Mutations in the GLI3 gene have been identified in several human malformation syndromes...
- Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouseKaren Niederreither
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
Development 129:3563-74. 2002..We suggest that RA signaling cooperates with a posteriorly restricted factor such as dHand, to generate a functional zone of polarizing activity (ZPA)...
- Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identityYing Litingtung
Vanderbilt University Medical Center, Department of Cell and Developmental Biology, Nashville, Tennessee 37232, USA
Nature 418:979-83. 2002..b>Gli3 (the gene implicated in human Greig cephalopolysyndactyly syndrome) is proposed to negatively regulate Shh by ..
- Differential requirement for Gli2 and Gli3 in ventral neural cell fate specificationJun Motoyama
Molecular Neuropathology Group, Brain Research Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Dev Biol 259:150-61. 2003..Here, we show that the transcription factors Gli2 and Gli3, mediators of Shh signaling, are required for the development of the ventral cell fates but make distinct ..
- Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of ShhYuting Chen
Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
Development 131:2339-47. 2004..Shh regulates digit formation largely by preventing cleavage of the Gli3 transcription factor to a repressor form that shuts off expression of Shh target genes...
- Excess TGF beta in neonatal lung injury and repairDavid Warburton; Fiscal Year: 2004..abstract_text> ..
- Lung epithelial and vascular morphogenesisDavid Warburton; Fiscal Year: 2006..abstract_text> ..
- Eda/Edar Regulation of Embryonic SMG DevelopmentTina Jaskoll; Fiscal Year: 2007....
- AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESISDavid Warburton; Fiscal Year: 2009..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
- DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATIONDavid Warburton; Fiscal Year: 2010..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..