Gli1

Summary

Gene Symbol: Gli1
Description: GLI-Kruppel family member GLI1
Alias: AV235269, Zfp-5, Zfp5, zinc finger protein GLI1, glioma-associated oncogene homolog, zinc finger protein 5
Species: mouse

Top Publications

  1. pmc Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    Courtney J Haycraft
    Department of Cell Biology, University of Alabama, Birmingham, Alabama, USA
    PLoS Genet 1:e53. 2005
  2. pmc Dual degradation signals control Gli protein stability and tumor formation
    Erik G Huntzicker
    Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:276-81. 2006
  3. ncbi Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression
    Terence D Capellini
    Department of Cell and Developmental Biology, Cornell University Weill Medical School, New York, NY 10021, USA
    Development 133:2263-73. 2006
  4. ncbi Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling
    Lia Panman
    Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical School, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 133:3419-28. 2006
  5. ncbi Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice
    Eric B Johnson
    Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Hum Mol Genet 14:3523-38. 2005
  6. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
  7. ncbi A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    H Sasaki
    Laboratory of Developmental Biology, Osaka University, Suita, Japan
    Development 124:1313-22. 1997
  8. ncbi Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004
  9. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999
  10. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004

Research Grants

  1. Neurogenesis, Inflammation and Irradiation Injury
    MICHELLE MONJE DEISSEROTH; Fiscal Year: 2003
  2. CLONING & ANALYSIS OF NOVEL TGF-BETA SIGNALING MOLECULES
    Xianxin Hua; Fiscal Year: 2002
  3. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
  4. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
  5. Function of tumor suppressor gene menin
    Xianxin Hua; Fiscal Year: 2008
  6. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
  7. Regulation of apoptosis by menin
    Xianxin Hua; Fiscal Year: 2009
  8. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
  9. TG737 SIGNALING PATHWAY AND POLYCYSTIC KIDNEY
    Bradley Yoder; Fiscal Year: 2003
  10. Cilial dysfunction and pathogenesis of obesity
    Bradley K Yoder; Fiscal Year: 2010

Detail Information

Publications171 found, 100 shown here

  1. pmc Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    Courtney J Haycraft
    Department of Cell Biology, University of Alabama, Birmingham, Alabama, USA
    PLoS Genet 1:e53. 2005
    ..Our data show that loss of Tg737 results in altered Gli3 processing that abrogates Gli3-mediated repression of Gli1 transcriptional activity...
  2. pmc Dual degradation signals control Gli protein stability and tumor formation
    Erik G Huntzicker
    Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:276-81. 2006
    ..We identify two independent destruction signals in Gli1, D(N) and D(C), and show that removal of these signals stabilizes Gli1 protein and rapidly accelerates tumor ..
  3. ncbi Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression
    Terence D Capellini
    Department of Cell and Developmental Biology, Cornell University Weill Medical School, New York, NY 10021, USA
    Development 133:2263-73. 2006
    ....
  4. ncbi Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling
    Lia Panman
    Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical School, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 133:3419-28. 2006
    ....
  5. ncbi Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice
    Eric B Johnson
    Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Hum Mol Genet 14:3523-38. 2005
    ..A similar autosomal recessive defect may also occur in man, where polysyndactyly, in combination with craniofacial abnormalities, is also part of a common genetic syndrome...
  6. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
    ..These studies demonstrate that Shh regulates growth and determines the shape of the tooth. However, Shh signaling is not essential for differentiation of ameloblasts or odontoblasts...
  7. ncbi A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    H Sasaki
    Laboratory of Developmental Biology, Osaka University, Suita, Japan
    Development 124:1313-22. 1997
    ..These results also support the idea that Gli/Ci are evolutionary conserved transcription factors in the Hedgehog signalling pathway...
  8. ncbi Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004
    ..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient...
  9. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999
    ..Together, the results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes...
  10. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
    ..All expression of the Hh target gene Gli1 is dependent on both Gli2 and Gli3...
  11. ncbi Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning
    Sohyun Ahn
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York, NY 10016, USA
    Cell 118:505-16. 2004
    ..Finally, by fate mapping Shh-responding cells in Gli2 and Gli3 mutant limbs, we demonstrate that a specific level of positive Hh signaling is not required to specify digit identities...
  12. pmc Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning
    Francesca V Mariani
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California 94158 2324, USA
    Nature 453:401-5. 2008
    ..We discuss how a two-signal model for P-D patterning can be integrated with the concept of early specification to explain the genetic data presented here...
  13. doi The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
    Setsu Endoh-Yamagami
    Department of Molecular Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Curr Biol 19:1320-6. 2009
    ..These results suggest a role for Kif7 in coordinating Hh signal transduction at the tip of cilia and preventing Gli3 cleavage into a repressor form in the presence of Hh...
  14. ncbi Altered neural cell fates and medulloblastoma in mouse patched mutants
    L V Goodrich
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 277:1109-13. 1997
    ..Mice heterozygous for the ptc mutation were larger than normal, and a subset of them developed hindlimb defects or cerebellar medulloblastomas, abnormalities also seen in BCNS patients...
  15. ncbi Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development
    Jennifer Selever
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, TX 77030, USA
    Dev Biol 276:268-79. 2004
    ..Our data show that Bmp4 in limb mesoderm regulates AER induction and maturation and implicate signaling from the AER in regulation of digit number and identity...
  16. ncbi Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    M P Matise
    Developmental Genetics Program and Howard Hughes Medical Institute, and Department of Cell Biology and Physiology and Neuroscience, NYU Medical Center, New York, NY 10016, USA
    Development 125:2759-70. 1998
    ..5 dpc, as in normal embryos. Finally, the spinal cord of Gli1/Gli2 zinc-finger-deletion double homozygous mutants appeared similar to Gli2 homozygotes, indicating that neither ..
  17. ncbi Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
    P M Lewis
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 105:599-612. 2001
    ..Thus, cholesterol modification is essential for the normal range of signaling. It also appears to be necessary for appropriate modulation of signaling by the Shh receptor, Ptc1...
  18. ncbi Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
    Sandra Blaess
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 133:1799-809. 2006
    ..Thus, the precise spatial and temporal regulation of Gli2A and Gli3R by Shh is instrumental in coordinating mid/hindbrain development in three dimensions...
  19. pmc Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 136:1387-96. 2009
    ....
  20. ncbi Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    Q Ding
    Program in Developmental Biology and Division of Endocrinology, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 125:2533-43. 1998
    ..We report that the expression of known Shh-responsive genes such as Ptc and Gli1 is downregulated in mutant mice lacking Gli2 function...
  21. ncbi Sonic hedgehog regulates the growth and patterning of the cerebellum
    N Dahmane
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Development 126:3089-100. 1999
    ..In addition, they provide a cellular context for medulloblastomas, childhood cancers of the cerebellum...
  22. pmc Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome
    Cheng Cui
    University of Pittsburgh, Department of Developmental Biology, 8111 Rangos Research Center, 530 45th Street, Pittsburgh, PA 15201, USA
    Dis Model Mech 4:43-56. 2011
    ..On the basis of these results, we hypothesize a role for the B9 domain in mother centriole targeting, a possibility that warrants further future investigations...
  23. pmc The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus
    Congxing Lin
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 356:40-50. 2011
    ..We provide genetic evidence that disruption of either signaling pathway results in severe microglossia. Altogether, we demonstrate a dynamic role for Wnt-β-Catenin signaling in the development of the oral apparatus...
  24. pmc Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning
    Asa Kolterud
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Gastroenterology 137:618-28. 2009
    ..We profiled cellular Hedgehog response patterns from embryonic day 10.5 (E10.5) to adult in murine antrum, pyloric region, small intestine, and colon...
  25. ncbi Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J)
    S Tole
    Department of Neurobiology, University of Chicago, Chicago, Illinois, 60637, USA
    Dev Biol 217:254-65. 2000
    ..Our findings suggest that in dorsal telencephalon Gli3 is needed to repress ventral telencephalic identity...
  26. ncbi Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
    Sylviane Dennler
    INSERM U697, Hopital Saint Louis, Pavillon Bazin, 1 avenue Claude Vellefaux, 75010 Paris, France
    Cancer Res 67:6981-6. 2007
    ..Herein, we show that TGF-beta induces the expression of the Hh signaling molecules Gli1 and Gli2 in various human cell types, including normal fibroblasts and keratinocytes, as well as various cancer ..
  27. doi Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouse
    Westley Heydeck
    Department of Biology, Eberly College of Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Dev Dyn 238:3035-42. 2009
    ..Finally, a significant decrease in cilia was found in Fuz homozygous mutants. In conclusion, Fuz plays an important role in cilia formation, Hh signal transduction, and embryonic development in mammals...
  28. pmc Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors
    Akil Merchant
    The Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Blood 115:2391-6. 2010
    ..We have analyzed hematopoietic stem cell (HSC) and progenitor function in mice with a homozygous deletion of Gli1 (Gli1(null))...
  29. pmc Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor
    Kerstin Seidel
    Department of Orofacial Sciences, Program in Craniofacial and Mesenchymal Biology, UCSF, 513 Parnassus Avenue, San Francisco, CA 94143 0442, USA
    Development 137:3753-61. 2010
    ..These results therefore reveal the existence of a positive-feedback loop in which differentiating progeny produce the signal that in turn allows them to be generated from stem cells...
  30. ncbi Loss of the Tg737 protein results in skeletal patterning defects
    Qihong Zhang
    The University of Alabama at Birmingham, Department of Cell Biology, Birmingham, Alabama 35294, USA
    Dev Dyn 227:78-90. 2003
    ..Collectively, the data argue for a dosage effect of Tg737 on the limb phenotypes and that the polydactyly is independent of Shh misexpression...
  31. ncbi Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development
    C C Hui
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Biol 162:402-13. 1994
    ..Consistent with this hypothesis, a naturally occurring Gli-3 mutation, the mouse extra-toes mutant; shows defects in both mesoderm- and ectoderm-derived tissues...
  32. ncbi Sonic hedgehog is required for cardiac outflow tract and neural crest cell development
    I Washington Smoak
    North Carolina State University, Raleigh, 27695, USA
    Dev Biol 283:357-72. 2005
    ..Our data suggest that SHH signaling does not act directly on NCCs as a survival factor, but rather acts to restrict the domains that NCCs can populate during early stages (e8.5-10.5) of cardiovascular and craniofacial development...
  33. pmc FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds
    Zhen Zhang
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Dev Cell 16:607-13. 2009
    ..This finding elucidates a novel aspect of the mechanism coordinating limb development along the A-P and P-D axes...
  34. pmc Midline signaling regulates kidney positioning but not nephrogenesis through Shh
    Piyush Tripathi
    Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 340:518-27. 2010
    ..These studies also provide insights into the pathogenesis of horseshoe kidneys and how congenital kidney defects can be caused by signals outside the renal primordia...
  35. pmc The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia
    Shinichi Miyagawa
    Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Endocrinology 152:2894-903. 2011
    ..The current study identified hedgehog signaling pathway as a key factor not only for initial development but also for sexually dimorphic development of the external genitalia in coordination with androgen signaling...
  36. pmc Role of epidermal primary cilia in the homeostasis of skin and hair follicles
    Mandy J Croyle
    Department of Cell Biology, University of Alabama at Birmingham Medical School, Birmingham, AL 35294, USA
    Development 138:1675-85. 2011
    ..Collectively, these data indicate that epidermal primary cilia may function in stress responses and epidermal homeostasis involving pathways other than those typically associated with primary cilia...
  37. pmc A primary cilia-dependent etiology for midline facial disorders
    Samantha A Brugmann
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
    Hum Mol Genet 19:1577-92. 2010
    ..to excessive Hedgehog responsiveness in facial mesenchyme, which is accompanied by broader expression domains of Gli1, Ptc and Shh, and reduced expression domains of Gli3...
  38. ncbi Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons
    Francesca Balordi
    Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:5936-47. 2007
    ..These results suggest that Hedgehog signaling is required for the maintenance of the B and C cell populations and indirectly for the migration of the neurons that are generated from the adult stem cell niche...
  39. ncbi Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    R J Wechsler-Reya
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    Neuron 22:103-14. 1999
    ..Blocking Shh function in vivo dramatically reduces GCP proliferation. These findings provide insight into the mechanisms of normal growth and tumorigenesis in the cerebellum...
  40. ncbi Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling
    Ryuma Haraguchi
    Center for Animal Resources and Development, CARD and Pharmaceutical Sciences, Kumamoto University, Honjo 2 2 1, Kumamoto, Japan
    Development 134:525-33. 2007
    ..Thus, the mesenchymal precursors for multiple urogenital structures derive from peri-cloacal mesenchyme and the coordination of urogenital organ formation from these precursors is orchestrated by Shh signals...
  41. pmc C2cd3 is required for cilia formation and Hedgehog signaling in mouse
    Amber N Hoover
    Department of Biology, Eberly College of Science, The Pennsylvania State University, 201 Life Science Building, University Park, PA 16802, USA
    Development 135:4049-58. 2008
    ..Interestingly, the human ortholog for this gene lies in proximity to the critical regions of Meckel-Gruber syndrome 2 (MKS2) and Joubert syndrome 2 (JBTS2), making it a potential candidate for these two human genetic disorders...
  42. doi Shh dependent and independent maintenance of basal midbrain
    Ariadna Perez-Balaguer
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Mech Dev 126:301-13. 2009
    ..Based on our results and recently published data, we suggest the existence of a specific genetic pathway for the specification of the mesencephalic red nucleus. Foxa2 could be the candidate gene that might control this genetic pathway...
  43. doi Patterning of ventral telencephalon requires positive function of Gli transcription factors
    Weiying Yu
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 334:264-75. 2009
    ..Together, these studies unravel a role for Gli transcription factors in mediating Shh signaling to control specification, differentiation and positioning of ventral telencephalic neurons...
  44. pmc Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract
    Junhao Mao
    Department of Cancer Biology, University of Massachusetts Medical School, LRB 405, Worcester, MA 01605, USA
    Development 137:1721-9. 2010
    ..Together, these studies provide new insights into tissue interactions underlying mammalian gastrointestinal organogenesis and disease...
  45. doi Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma
    Ryan J Ward
    Developmental and Stem Cell Biology, Hospital for Sick Children, ON, Canada M5G 1X8
    Cancer Res 69:4682-90. 2009
    ....
  46. ncbi beta-1,4-N-Acetylgalactosaminyltransferase involved in ganglioside synthesis: cDNA sequence, expression, and chromosome mapping of the mouse gene
    K Sango
    Section on Biochemical Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 27:362-5. 1995
    ..The Ggm2 gene was mapped to a distal position on mouse chromosome 10 that is homologous to a portion of human chromosome 12...
  47. ncbi Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    H Sasaki
    Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565 0871, Japan
    Development 126:3915-24. 1999
    ..A similar regulatory mechanism involving the N-terminal region was also found for Gli3, but not for Gli1. When the Shh signal derived from the notochord is received by the neural plate, the widely expressed Gli2 and Gli3 ..
  48. ncbi Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    J Lee
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU Medical Center, New York, NY 10016, USA
    Development 124:2537-52. 1997
    ..In frog embryos, Gli1 is expressed transiently in the prospective floor plate during gastrulation and in cells lateral to the midline ..
  49. ncbi Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh
    Sanne Kuijper
    Hubrecht Laboratory, The Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Dev Biol 285:533-44. 2005
    ..Total lack of reporter expression in a Gli3-/- background confirms the existence of Gli3-dependent and -independent Alx4 expression in the limb bud. Apparently, these two modules of Alx4 expression are linked to dissimilar functions...
  50. ncbi Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina
    Yaping Wang
    Molecular Medicine Program, Ottawa Health Research Institute and University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Development 132:5103-13. 2005
    ....
  51. doi Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb
    Natalie C Butterfield
    The University of Queensland, Institute for Molecular Bioscience, Queensland, Australia
    Development 136:3515-24. 2009
    ..These results establish the importance of the downstream consequences of Hh pathway repression, and identify Ptc1 as a key player in limb patterning even prior to the onset of Shh expression...
  52. pmc Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1
    Ramesh Palaniswamy
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, SE 14157 Sweden
    BMC Mol Biol 11:32. 2010
    ..Even though alternative splicing also occurs in the 5' and 3' untranslated regions (UTRs) of mRNAs, the understanding of the significance and the regulation of these variations is rather limited...
  53. pmc beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region
    Dmitri Chilov
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    PLoS ONE 5:e10881. 2010
    ..These results highlight the role of beta-catenin in establishment of neuroectodermal signalling centers, promoting region-specific gene expression and regulation of cell fate determination...
  54. ncbi The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
    N Dahmane
    Skirball Institute of Biomolecular Medicine, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 128:5201-12. 2001
    ..Using the in vivo tadpole assay system, we further show that misexpression of GLI1 induces CNS hyperproliferation that depends on the activation of endogenous Gli1 function...
  55. ncbi The GLI gene is a member of the Kruppel family of zinc finger proteins
    K W Kinzler
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Nature 332:371-4. 1988
    ..The link between the developmentally important Kruppel family of genes and GLI is interesting considering the similarities between developing embryonic and neoplastic tissue...
  56. ncbi Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
    D J Epstein
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 122:2885-94. 1996
    ..As both of these are targets of Drosophila Hh signaling, our data point to an evolutionary conservation in both the mechanisms of signaling and the effectors of the signaling pathway...
  57. ncbi The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants
    Z Hardcastle
    Department of Craniofacial Development, UMDS, Guy s Hospital, London Bridge, London SE1 9RT, UK
    Development 125:2803-11. 1998
    The expression of genes involved in the Sonic Hedgehog signalling pathway, including Shh, Ptc, Smo, Gli1, Gli2 and Gli3, were found to be expressed in temporal and spatial patterns during early murine tooth development, suggestive of a ..
  58. ncbi Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity
    A Zuniga
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Development 126:13-21. 1999
    ..Concurrently, Gli3 functions independently of formin during initial posterior nesting of 5'HoxD domains, whereas their subsequent distal restriction and anterior expansion depends on genetic interaction of Gli3 and formin...
  59. ncbi Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells
    D H Rowitch
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 19:8954-65. 1999
    ..Thus, Hedgehog signaling may contribute to CNS tumorigenesis by directly enhancing proliferation and preventing neural differentiation in selected precursor cells...
  60. ncbi Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1
    M T Lewis
    Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA
    Development 126:5181-93. 1999
    ..Data demonstrate a critical mammary role for at least one component of the hedgehog signaling network and suggest that Ihh is the primary hedgehog gene active in the gland...
  61. ncbi Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells
    Ya Ping Wang
    Molecular Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Nat Neurosci 5:831-2. 2002
    ..Here we show that Sonic hedgehog signaling from RGCs is required for the normal laminar organization in the vertebrate retina...
  62. ncbi Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization
    Amel Gritli-Linde
    Department of Oral Biochemistry, Sahlgrenska Academy at Goteborg University, Sweden
    Development 129:5323-37. 2002
    ..Furthermore, we provide evidence that Shh signaling between ameloblasts and the overlying stratum intermedium may involve subcellular localization of Patched 2 and Gli1 mRNAs, both of which are targets of Shh signaling in these cells.
  63. pmc Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
    Ping Dai
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Ibaraki, Japan
    Genes Dev 16:2843-8. 2002
    ..zone of polarizing activity blocks Gli3 processing and then induces the expression of Gli3 target genes, including Gli1. Here we report that the Ski corepressor binds to Gli3 and recruits the histone deacetylase complex...
  64. ncbi Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex
    Veronica Palma
    The Skirball Institute and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 131:337-45. 2004
    ..These findings identify a crucial mechanism for the regulation of the number of cells with stem cell properties that is unexpectedly conserved in different stem cell niches...
  65. ncbi Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
    JoMichelle D Corrales
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 131:5581-90. 2004
    ..Expression of the Shh target gene Gli1 is also highest in the anterior medial cerebellum, but is restricted to proliferating GCPs and Bergmann glia...
  66. ncbi Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
    Aimin Liu
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Mailstop 8322, Box 6511, Aurora, CO 80045, USA
    Development 132:3103-11. 2005
    ..Sonic hedgehog (Shh) expression is normal, yet Ptch1 and Gli1, two known targets of Hh signaling, are greatly reduced, consistent with loss of Shh signaling...
  67. ncbi Expression patterns of Hedgehog signalling pathway members during mouse palate development
    Ritva Rice
    Department of Craniofacial Development, King s College London, Floor 28 Guy s Tower, St Thomas Street, London SE1 9RT, UK
    Gene Expr Patterns 6:206-12. 2006
    ..Smoothened and transcriptional effectors Gli1-3, and Hh regulator Gas1 are expressed widely in the palatal mesenchyme...
  68. ncbi FGF signalling generates ventral telencephalic cells independently of SHH
    Grigoriy Gutin
    Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Development 133:2937-46. 2006
    ..Yet, in the Fgfr1;Fgfr2 mutant, Shh remains expressed, as does Gli1, the transcription of which depends on SHH activity, suggesting that FGF signalling acts independently of SHH to ..
  69. pmc Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
    Barbara Stecca
    Department of Genetic Medicine and Development, University of Geneva School of Medicine, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 104:5895-900. 2007
    ..Moreover, we show that oncogenic RAS-induced melanomas in transgenic mice express Gli1 and require Hh-Gli signaling in vitro and in vivo...
  70. ncbi Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
    Steven A Vokes
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 134:1977-89. 2007
    ..to mediate the specification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) transcriptional network...
  71. doi Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells
    Gabriel D Dakubo
    Ottawa Health Research Institute, Ottawa, ON, Canada K1H 8L6
    Brain Res 1228:27-42. 2008
    ..was initiated in the optic nerves of these mutant mice; however, the expression of Hedgehog (Hh) target genes, Gli1 and Ptch1 and cell cycle genes, Ccnd1 and Cdc25b in the optic nerves were downregulated...
  72. ncbi Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1
    M Hynes
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Neuron 19:15-26. 1997
    ..These findings demonstrate that GLI-1 can reproduce the cell patterning actions of Shh in the developing nervous system and provide support for the hypothesis that it is a mediator of the Shh signal in vertebrates...
  73. ncbi Evidence for the involvement of the Gli gene family in embryonic mouse lung development
    J C Grindley
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 188:337-48. 1997
    ..Thus, our data indicate that one of the Gli genes, Gli3, is essential for normal lung development, and that another, Gli, can be placed downstream of Shh signaling in the lung...
  74. ncbi Essential role for Sonic hedgehog during hair follicle morphogenesis
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 205:1-9. 1999
    ..The expression of Gli1 and Ptc1 was reduced in Shh -/- dermal condensates and they failed to evolve into hair follicle papillae, ..
  75. ncbi Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
    P Dai
    Laboratory of Molecular Genetics, Tsukuba Life Science Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 274:8143-52. 1999
    ..Here, we report distinct roles for GLI1 and GLI3 in Sonic hedgehog (Shh) signaling...
  76. ncbi Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1
    Q Ding
    Program in Developmental Biology The Hospital for Sick Children Department of Molecular and Medical Genetics University of Toronto 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Curr Biol 9:1119-22. 1999
    ..Although the Gli1, Gli2, and Gli3 zinc finger proteins are known to be effectors of Hh signaling in vertebrates, the mechanisms ..
  77. ncbi Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
    H L Park
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology and Physiology and Neuroscience, New York University Medical School, New York, NY 10016, USA
    Development 127:1593-605. 2000
    ..to discriminate between overlapping versus unique requirements for the three Gli genes in mice, we have produced a Gli1 mutant and analyzed the phenotypes of Gli1/Gli2 and Gli1/3 double mutants...
  78. ncbi Hedgehog signals regulate multiple aspects of gastrointestinal development
    M Ramalho-Santos
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Development 127:2763-72. 2000
    ..These results show that Hedgehog signals are essential for organogenesis of the mammalian gastrointestinal tract and suggest that mutations in members of this signaling pathway may be involved in human gastrointestinal malformations...
  79. ncbi Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma
    H Hahn
    Institute of Pathology, TUM Technical University of Munich GSF Research Center of Environment and Health, Ingolstadter Landstrasse 1, 85758 Neuherberg, Federal Republic of Germany
    J Biol Chem 275:28341-4. 2000
    ..They also identify Igf2 as a potential target for medulloblastoma and RMS...
  80. ncbi Some distal limb structures develop in mice lacking Sonic hedgehog signaling
    P Kraus
    Ronald O Perelman Department of Dermatology, New York University School of Medicine, NY, New York, USA
    Mech Dev 100:45-58. 2001
    ..Finally, we show that Shh is also required for outgrowth of the limb ectoderm and thus for the formation of a distinct limb compartment...
  81. ncbi Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
    C Chiang
    Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Dev Biol 236:421-35. 2001
    ..According to this model, the limb bud signaling centers, including the zone of polarizing activity (ZPA) acting through Shh, are required to elaborate upon the axial information provided by the native limb field prepattern...
  82. pmc Anorectal malformations caused by defects in sonic hedgehog signaling
    R Mo
    Program in Developmental Biology, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 159:765-74. 2001
    ....
  83. ncbi Unique functions of Sonic hedgehog signaling during external genitalia development
    R Haraguchi
    Center for Animal Resources and Development CARD and Graduate School of Molecular and Genomic Pharmacy, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Development 128:4241-50. 2001
    ..These results suggest a dual mode of Shh function, first by the regulation of initiating GT outgrowth, and second, by subsequent GT differentiation...
  84. ncbi Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling
    Murielle Rallu
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York 10016, USA
    Development 129:4963-74. 2002
    ..In addition these results support the idea that, in addition to hedgehog signaling, a Shh-independent pathways must act during development to pattern the telencephalon...
  85. ncbi Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb
    Ying Liu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Development 129:5289-300. 2002
    ..Our data provide evidence that Gas1 acts to maintain high levels of FGF10 at the tip mesenchyme and support the proposal that Fgf10 expression in this region is crucial for maintaining Fgf8 expression in the AER...
  86. ncbi Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
    Anna Marie Kenney
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Development 130:15-28. 2003
    ..Together, these findings identify Nmyc as a direct target of the Shh pathway that functions to regulate cell cycle progression in cerebellar granule neuron precursors...
  87. ncbi Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development
    Gabriel D Dakubo
    Molecular Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    Development 130:2967-80. 2003
    ..Together, these data provide a novel insight into the source of Hh that promotes neuroepithelial cell development in the mammalian optic disc and stalk...
  88. ncbi Combined activities of hedgehog signaling inhibitors regulate pancreas development
    Hiroshi Kawahira
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 130:4871-9. 2003
    ..Reduction of Fgf10 expression in Hhip homozygous mutants suggests that at least some of the observed phenotypes result from hedgehog-mediated inhibition of Fgf signaling at early stages...
  89. ncbi Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches
    Robert Machold
    Developmental Genetics Program and Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Neuron 39:937-50. 2003
    ..These results suggest that hedgehog signaling is required to maintain progenitor cells in the postnatal telencephalon...
  90. ncbi Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction
    Laura Buttitta
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Development 130:6233-43. 2003
    ..To further dissect the function of each Gli, we used adenovirus to overexpress Gli1, Gli2 and Gli3 in presomitic mesoderm explants...
  91. ncbi FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
    Oleg V Bulgakov
    The Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Development 131:2149-59. 2004
    ..Although it is expressed broadly, FKBP8 is required to antagonize SHH signaling primarily in neural tissues, suggesting that hedgehog signal transduction is subject to cell-type specific modulation during mammalian development...
  92. ncbi Restriction of sonic hedgehog signalling during early tooth development
    Martyn T Cobourne
    Department of Craniofacial Development and Orthodontics, GKT Dental Institute, King s College London, Floor 28, Guy s Hospital, London SE1 9RT, UK
    Development 131:2875-85. 2004
    ..We show that at these stages in the murine mandibular arch in the absence of epithelium, the Shh targets Ptc1 and Gli1 are upregulated in diastema mesenchyme, an edentulous region between the sites of molar and incisor tooth formation...
  93. ncbi Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1
    Mark Zervas
    Howard Hughes Medical Institute, Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Neuron 43:345-57. 2004
    ..Finally, we also uncovered transient and differential genetic lineages of ventral midbrain dopaminergic and ventral hindbrain serotonergic neuronal precursors with respect to Wnt1 and Gli1 expression.
  94. ncbi Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation
    Aileen McDermott
    Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Development 132:345-57. 2005
    ..We report that Gli genes are differentially expressed in the mouse somite. Gli2 and Gli3 are essential for Gli1 expression in somites, establishing Gli2 and Gli3 as primary mediators and Gli1 as a secondary mediator of Shh ..
  95. ncbi Gli1 is important for medulloblastoma formation in Ptc1+/- mice
    Hiromichi Kimura
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Oncogene 24:4026-36. 2005
    ..activation of Smoothened (Smo), which in turn stimulates expression of downstream target genes including Ptc1 and Gli1. Gli1 is a member of a family of DNA-binding zinc-finger proteins, including Gli2 and Gli3, that function in ..
  96. ncbi Gli3 null mice display glandular overgrowth of the developing stomach
    Jae H Kim
    Program in Integrative Biology, The Research Institute, The Hospital for Sick Children, Toronto, Canada
    Dev Dyn 234:984-91. 2005
    ..The embryonic stomach is a unique model of the Hedgehog pathway function and one that may help to uncover some of the mechanisms underlying the development of intestinal metaplasia...
  97. ncbi Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
    Lydia Koziel
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Development 132:5249-60. 2005
    ..Furthermore, by regulating distal chondrocyte differentiation, Gli3 seems to position the domain of PTHrP expression...
  98. ncbi Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
    Paul C Barnfield
    Hospital for Sick Children, Program in Developmental Biology, 101 College Street, TMDT, Rm 13 314, Toronto, ON, Canada M5G 1L7
    Differentiation 73:397-405. 2005
    ..We demonstrate here that Su(fu) prevents the nuclear accumulation of Gli1 and Gli2 through multiple mechanisms...
  99. pmc Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
    Yong Pan
    Weill Medical College of Cornell University, 1300 York Avenue, Room W404, New York, NY 10021, USA
    Mol Cell Biol 26:3365-77. 2006
    ..Both processing and degradation of Gli2 are suppressed by Shh signaling in vivo. Our findings provide the first demonstration of a molecular mechanism by which the Gli2 transcriptional activity is regulated by Shh signaling...
  100. ncbi Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    Wei Zhang
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Cell 10:657-65. 2006
    ..Specific Cdo domains required for its promyogenic effect are dispensable for its Shh signaling role, suggesting that Cdo has multiple, independent functions...
  101. ncbi The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
    Toyoaki Tenzen
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Cell 10:647-56. 2006
    ..Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity. We propose a model where Cdo and Boc enhance Shh signaling within its target field...

Research Grants14

  1. Neurogenesis, Inflammation and Irradiation Injury
    MICHELLE MONJE DEISSEROTH; Fiscal Year: 2003
    ..abstract_text> ..
  2. CLONING & ANALYSIS OF NOVEL TGF-BETA SIGNALING MOLECULES
    Xianxin Hua; Fiscal Year: 2002
    ..The novel cDNAs isolated by the antisense approach will be tested for its potential role as tumor suppressor genes. ..
  3. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  4. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  5. Function of tumor suppressor gene menin
    Xianxin Hua; Fiscal Year: 2008
    ..abstract_text> ..
  6. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  7. Regulation of apoptosis by menin
    Xianxin Hua; Fiscal Year: 2009
    ..abstract_text> ..
  8. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  9. TG737 SIGNALING PATHWAY AND POLYCYSTIC KIDNEY
    Bradley Yoder; Fiscal Year: 2003
    ..Overall, results generated from this proposal will give important insight into the biological function of Tg737 and how disruption of the Tg737/polycystin-1 signaling pathway results in the formation of renal cyst. ..
  10. Cilial dysfunction and pathogenesis of obesity
    Bradley K Yoder; Fiscal Year: 2010
    ....
  11. Conserved Mechanisms of Ciliogenesis
    Bradley Yoder; Fiscal Year: 2007
    ..abstract_text> ..
  12. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
  13. Roles for HIC1 in neural development and tumor suppression
    DAVID NEIL WATKINS; Fiscal Year: 2010
    ..These findings are of direct relevance to many cancers, since deregulation of pathways known to be important in embryonic development can help us understand the basis of human malignancy. ..