Gem

Summary

Gene Symbol: Gem
Description: GTP binding protein (gene overexpressed in skeletal muscle)
Alias: AV020497, GTP-binding protein GEM, GTP-binding mitogen-induced T-cell protein, RAS-like protein KIR
Species: mouse

Top Publications

  1. doi Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons
    Elisa J Hoekstra
    Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Neurosci 37:23-32. 2013
  2. ncbi 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity
    Pascal Beguin
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
    J Cell Sci 118:1923-34. 2005
  3. pmc Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity
    Y Ward
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute NIH, Building 10, Room 3B43, Bethesda, MD 20892, USA
    Mol Cell Biol 24:651-61. 2004
  4. pmc Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling
    Jenny E Gunton
    Diabetes and Transcription Factors Group, Garvan Institute of Medical Research, Sydney, Australia
    PLoS ONE 7:e39462. 2012
  5. pmc A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing
    Jiajun Feng
    Department of Biological Sciences, National University of Singapore, Singapore
    Biol Reprod 79:546-61. 2008
  6. ncbi Genetic regulation of mouse stem cells: identification of two keratinocyte stem cell regulatory loci
    N V Popova
    Department of Dermatology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, VC 15, New York, NY 10032, USA
    Curr Top Microbiol Immunol 280:111-37. 2004
  7. ncbi Nuclear transport of Kir/Gem requires specific signals and importin alpha5 and is regulated by calmodulin and predicted serine phosphorylations
    Ramasubbu N Mahalakshmi
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Traffic 8:1150-63. 2007
  8. ncbi RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain
    Pascal Beguin
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
    J Biol Chem 282:11509-20. 2007
  9. ncbi Direct inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltage-dependent Ca2+ channels by Gem
    Takehide Sasaki
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 280:9308-12. 2005
  10. pmc Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases
    L Cohen
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024 1662
    Proc Natl Acad Sci U S A 91:12448-52. 1994

Scientific Experts

  • Jenny E Gunton
  • E Piddini
  • N V Popova
  • Pascal Beguin
  • Elisa J Hoekstra
  • Jiajun Feng
  • Ramasubbu N Mahalakshmi
  • Kazuaki Nagashima
  • Takehide Sasaki
  • Y Ward
  • N A Jenkins
  • N G Copeland
  • Lars P van der Heide
  • Raymond D Schellevis
  • Annemarie J A van der Linden
  • Lars von Oerthel
  • Frank C P Holstege
  • Marian J Groot-Koerkamp
  • Marten P Smidt
  • K Kelly
  • Gerard Scheppink
  • A Alavizadeh
  • K Huang
  • Mark A Lawson
  • G B Downes
  • Philippa Melamed
  • Walter Hunziker
  • Mei Yong Ng
  • Nobuya Inagaki
  • Masaru Miyazaki
  • Susumu Seino
  • Tadao Shibasaki
  • H Chen
  • T Santoro
  • B Spinelli
  • S R Ikeda
  • M J Quon
  • J Maguire
  • R Fischer
  • M Bucan
  • K P Steel
  • A E Kiernan
  • C Lo
  • P Nolan
  • K D Johnson
  • E H Bresnick
  • T Vandergon
  • J Kimble
  • A G Petcherski
  • E A Mosser
  • N Gautam
  • D J Gilbert
  • L Cohen
  • M W Berchtold
  • Y Wei
  • J Anagli
  • O W McBride
  • K B Avraham
  • R Mohr
  • D Dorin
  • N Rosenberg
  • P Jensen
  • U Siebenlist
  • Y Y Chen
  • M Huang
  • R Kato
  • D Afar
  • A Goga
  • F Tamanoi
  • J Yewdell

Detail Information

Publications20

  1. doi Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons
    Elisa J Hoekstra
    Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Neurosci 37:23-32. 2013
    ..Taken together, microarray analysis of an LMX1A-overexpression cell system resulted in the identification of novel direct or indirect downstream targets of Lmx1a in mdDA neurons: Grb10, Rgs4 and Vmat2...
  2. ncbi 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity
    Pascal Beguin
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
    J Cell Sci 118:1923-34. 2005
    Individual members of the RGK family of Ras-related GTPases, which comprise Rad, Gem/Kir, Rem and Rem2, have been implicated in important functions such as the regulation of voltage-gated calcium channel activity and remodeling of cell ..
  3. pmc Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity
    Y Ward
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute NIH, Building 10, Room 3B43, Bethesda, MD 20892, USA
    Mol Cell Biol 24:651-61. 2004
    b>Gem is a small GTP-binding protein that has a ras-like core and extended chains at each terminus...
  4. pmc Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling
    Jenny E Gunton
    Diabetes and Transcription Factors Group, Garvan Institute of Medical Research, Sydney, Australia
    PLoS ONE 7:e39462. 2012
    ..Regulation of calcium handling in beta-cells remains incompletely understood. Gem, a member of the RGK (Rad/Gem/Kir) family regulates calcium channel handling in other cell types, and Gem over-..
  5. pmc A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing
    Jiajun Feng
    Department of Biological Sciences, National University of Singapore, Singapore
    Biol Reprod 79:546-61. 2008
    ..This study has revealed a number of novel factors that alter gonadotropin expression and gonadotroph function, and likely mediate or moderate effects of the regulatory hormones...
  6. ncbi Genetic regulation of mouse stem cells: identification of two keratinocyte stem cell regulatory loci
    N V Popova
    Department of Dermatology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, VC 15, New York, NY 10032, USA
    Curr Top Microbiol Immunol 280:111-37. 2004
    ....
  7. ncbi Nuclear transport of Kir/Gem requires specific signals and importin alpha5 and is regulated by calmodulin and predicted serine phosphorylations
    Ramasubbu N Mahalakshmi
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Traffic 8:1150-63. 2007
    Kir/Gem, together with Rad, Rem and Rem2, is a member of the RGK small GTP-binding protein family. These multifunctional proteins regulate voltage-gated calcium channel (VGCC) activity and cell-shape remodeling...
  8. ncbi RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain
    Pascal Beguin
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
    J Biol Chem 282:11509-20. 2007
    RGK proteins (Kir/Gem, Rad, Rem, and Rem2) form a small subfamily of the Ras superfamily...
  9. ncbi Direct inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltage-dependent Ca2+ channels by Gem
    Takehide Sasaki
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 280:9308-12. 2005
    The Ras-related small G-protein Gem regulates voltage-dependent Ca2+ channels (VDCCs) through interaction with the beta-subunit of the VDCC. This action of Gem is mediated by regulated alpha1-subunit expression at the plasma membrane...
  10. pmc Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases
    L Cohen
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024 1662
    Proc Natl Acad Sci U S A 91:12448-52. 1994
    ..BCR/ABL and v-Abl induce transcription of the kir gene via specific signaling pathway(s), but kir overexpression alone is not sufficient to mediate transformation...
  11. ncbi Identification of two keratinocyte stem cell regulatory loci implicated in skin carcinogenesis
    Natalia V Popova
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Carcinogenesis 24:417-25. 2003
    ....
  12. pmc The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9
    E Piddini
    EMBL, Cell Biology and Biophysics Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO J 20:4076-87. 2001
    b>Gem belongs to the Rad/Gem/Kir (RGK) subfamily of Ras-related GTPases, which also comprises Rem, Rem2 and Ges...
  13. ncbi Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem
    P Beguin
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Nature 411:701-6. 2001
    ..We report here that the GTP-bound form of kir/Gem, identified originally as a Ras-related small G-protein that binds CaM, inhibits high-voltage-activated Ca2+ ..
  14. ncbi A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis
    K Huang
    University of Wisconsin Medical School, Department of Pharmacology, Molecular and Cellular Pharmacology Program, 387 Medical Science Center, 1300 University Avenue, 53706, Madison, WI, USA
    Gene 252:137-45. 2000
    ..CeWWP1 must therefore have unique and nonredundant functions critical for embryogenesis...
  15. ncbi Chromosomal mapping of five mouse G protein gamma subunits
    G B Downes
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Genomics 57:173-6. 1999
    ..Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes...
  16. ncbi Chromosomal organization and transcriptional regulation of human GEM and localization of the human and mouse GEM loci encoding an inducible Ras-like protein
    T Santoro
    Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Genomics 30:558-64. 1995
    The mitogen-induced gene, GEM, encodes a GTP-binding protein that belongs to a new family within the Ras superfamily. The regulated expression pattern of Gem suggests a role for this protein in cellular responses to growth stimulation...
  17. ncbi Calmodulin binds to and inhibits GTP binding of the ras-like GTPase Kir/Gem
    R Fischer
    Department of Veterinary Biochemistry, University Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol Chem 271:25067-70. 1996
    Recently, a new subfamily of Ras-related GTP-binding proteins consisting of Rad (Ras associated with diabetes), Gem (immediate early gene expressed in mitogen-stimulated T-cells), and Kir (tyrosine kinase-inducible Ras-like) was ..
  18. ncbi Gem: an induced, immediate early protein belonging to the Ras family
    J Maguire
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Science 265:241-4. 1994
    A gene encoding a 35-kilodalton guanosine triphosphate (GTP)-binding protein, Gem, was cloned from mitogen-induced human peripheral blood T cells...
  19. ncbi The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects
    A Alavizadeh
    Department of Psychiatry and Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Biol 234:244-60. 2001
    ..In summary, our findings indicate that Wheels, a gene which is essential for the survival of the embryo, may link diverse processes involved in vascular, hindbrain, and inner ear development...