Gdnf

Summary

Gene Symbol: Gdnf
Description: glial cell line derived neurotrophic factor
Alias: AI385739, ATF, glial cell line-derived neurotrophic factor, astrocyte-derived trophic factor, neurotrophic factor
Species: mouse

Top Publications

  1. ncbi Neurturin, a relative of glial-cell-line-derived neurotrophic factor
    P T Kotzbauer
    Division of Laboratory Medicine, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 384:467-70. 1996
  2. ncbi The GDNF family ligands and receptors - implications for neural development
    R H Baloh
    Departments of Pathology and Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Neurobiol 10:103-10. 2000
  3. ncbi GDNF is a chemoattractant for enteric neural cells
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, 3010, Australia
    Dev Biol 229:503-16. 2001
  4. ncbi The GDNF family: signalling, biological functions and therapeutic value
    Matti S Airaksinen
    Programme of Molecular Neurobiology, Institute of Biotechnology, P O Box 56, Viikki Biocenter, FIN 00014, University of Helsinki, Finland
    Nat Rev Neurosci 3:383-94. 2002
  5. ncbi GDNF availability determines enteric neuron number by controlling precursor proliferation
    Scott Gianino
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 130:2187-98. 2003
  6. ncbi Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme
    Deepali Pitre Poladia
    Center for Cell and Vascular Biology, Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    Dev Biol 291:325-39. 2006
  7. ncbi Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
    Akio Kobayashi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2809-23. 2005
  8. ncbi Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse
    J P Golden
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Exp Neurol 158:504-28. 1999
  9. ncbi Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis
    Dipa Natarajan
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 129:5151-60. 2002
  10. pmc Kidney development in the absence of Gdnf and Spry1 requires Fgf10
    Odysse Michos
    Department of Genetics and Development, Columbia University, New York, New York, USA
    PLoS Genet 6:e1000809. 2010

Research Grants

  1. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2001
  2. The Role of RET in Spermatogenesis
    Cathy Naughton; Fiscal Year: 2005
  3. Optimizing Testis Transplantation to Study RET Signaling
    Cathy Naughton; Fiscal Year: 2005
  4. Transcription Factor P53 in Terminal Nephron Different
    Zubaida Saifudeen; Fiscal Year: 2004
  5. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2007
  6. Mitochondrial Dysfunction in Down's Syndrome
    JORGE A BUSCIGLIO; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications125 found, 100 shown here

  1. ncbi Neurturin, a relative of glial-cell-line-derived neurotrophic factor
    P T Kotzbauer
    Division of Laboratory Medicine, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 384:467-70. 1996
    ..Here we describe the purification and cloning of a new neurotrophic factor, identified on the basis of its ability to support the survival of sympathetic neurons in culture...
  2. ncbi The GDNF family ligands and receptors - implications for neural development
    R H Baloh
    Departments of Pathology and Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Neurobiol 10:103-10. 2000
    The glial cell line derived neurotrophic factor (GDNF) family has recently been expanded to include four members, and the interactions between these neurotrophic factors and their unique receptor system is now beginning to be understood...
  3. ncbi GDNF is a chemoattractant for enteric neural cells
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, 3010, Australia
    Dev Biol 229:503-16. 2001
    In situ hybridization revealed that GDNF mRNA in the mid- and hindgut mesenchyme of embryonic mice was minimal at E10.5 but was rapidly elevated at all gut regions after E11, but with a slight delay (0.5 days) in the hindgut...
  4. ncbi The GDNF family: signalling, biological functions and therapeutic value
    Matti S Airaksinen
    Programme of Molecular Neurobiology, Institute of Biotechnology, P O Box 56, Viikki Biocenter, FIN 00014, University of Helsinki, Finland
    Nat Rev Neurosci 3:383-94. 2002
    Members of the nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) families comprising neurotrophins and GDNF-family ligands (GFLs), respectively are crucial for the development and maintenance of ..
  5. ncbi GDNF availability determines enteric neuron number by controlling precursor proliferation
    Scott Gianino
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 130:2187-98. 2003
    ..These analyses demonstrate that glial cell line-derived neurotrophic factor (GDNF) and neurturin are important for different aspects of ENS development...
  6. ncbi Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme
    Deepali Pitre Poladia
    Center for Cell and Vascular Biology, Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    Dev Biol 291:325-39. 2006
    ..In metanephric mesenchymal rudiments, fgfr1 and fgfr2 appear to function downstream of Eya1 and Six1, but upstream of Six2, Sall1, and Pax2. Finally, this is the first example of renal aplasia in a conditional knockout model...
  7. ncbi Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
    Akio Kobayashi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2809-23. 2005
    ..We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Mullerian duct, the anlage of the female reproductive tract...
  8. ncbi Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse
    J P Golden
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Exp Neurol 158:504-28. 1999
    ..The GDNF family of neurotrophic factors currently has four members: neurturin (NRTN), glial cell line-derived neurotrophic factor (GDNF), persephin, and artemin...
  9. ncbi Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis
    Dipa Natarajan
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 129:5151-60. 2002
    ..We provide evidence that activation of the receptor tyrosine kinase RET by glial cell line-derived neurotrophic factor (GDNF) is required for the directional migration of ENS progenitors towards and within the gut wall...
  10. pmc Kidney development in the absence of Gdnf and Spry1 requires Fgf10
    Odysse Michos
    Department of Genetics and Development, Columbia University, New York, New York, USA
    PLoS Genet 6:e1000809. 2010
    b>GDNF signaling through the Ret receptor tyrosine kinase (RTK) is required for ureteric bud (UB) branching morphogenesis during kidney development in mice and humans...
  11. doi The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes
    Thomas W Gould
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    J Neurosci 28:2131-46. 2008
    Glial cell line-derived neurotrophic factor (GDNF) regulates multiple aspects of spinal motoneuron (MN) development, including gene expression, target selection, survival, and synapse elimination, and mice lacking either GDNF or its ..
  12. pmc Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme
    Gangadharan Sajithlal
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Dev Biol 284:323-36. 2005
    Although it is well established that the Gdnf-Ret signal transduction pathway initiates metanephric induction, no single regulator has yet been identified to specify the metanephric mesenchyme or blastema within the intermediate mesoderm, ..
  13. pmc Renal collecting system growth and function depend upon embryonic γ1 laminin expression
    Dong Hua Yang
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Development 138:4535-44. 2011
    ..mRNA levels for fibroblast growth factor 2 (FGF2) and mediators of the GDNF/RET and WNT11 signaling pathway were also decreased...
  14. ncbi SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site
    Uta Grieshammer
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA
    Dev Cell 6:709-17. 2004
    ..It begins when a single ureteric bud emerges from the nephric duct in response to GDNF secreted by the adjacent nephrogenic mesenchyme...
  15. pmc Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis
    E de Graaff
    Division of Developmental Neurobiology, Medical Research Council MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Genes Dev 15:2433-44. 2001
    ..Our findings show that RET9 and RET51 have different signaling properties in vivo and define specific temporal and spatial requirements of c-Ret function during renal development and histogenesis of the enteric nervous system...
  16. ncbi Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse
    Melissa Zwick
    Department of Anatomy, University of Kentucky School of Medicine, Lexington, Kentucky 40536, USA
    J Neurosci 22:4057-65. 2002
    ..between embryonic day 16 and postnatal day 14 and become responsive to glial cell line-derived growth factor (GDNF), a member of the transforming growth factor beta (TGF-beta) family...
  17. ncbi Expression of GDNF and GFR alpha 1 in mouse taste bud cells
    Masako Takeda
    Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Ishikari, Hokkaido 061 0293, Japan
    J Comp Neurol 479:94-102. 2004
    GDNF (glial cell line-derived neurotrophic factor) affects the survival and maintenance of central and peripheral neurons...
  18. ncbi Astrocyte-derived transgene GDNF promotes complete and long-term survival of adult facial motoneurons following avulsion and differentially regulates the expression of transcription factors of AP-1 and ATF/CREB families
    Alexander Parsadanian
    Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Neurol 200:26-37. 2006
    Glial-cell-line-derived neurotrophic factor (GDNF) is a potent survival factor for motoneurons (MNs)...
  19. pmc Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter
    Zhen X Mahoney
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:19872-7. 2006
    ..Our results suggest that (i) besides its well documented role in regulating epithelial polarity, Dlgh1 also regulates smooth muscle orientation, and (ii) human DLG1 mutations may contribute to hereditary forms of hydronephrosis...
  20. pmc Downregulation of Spry-1, an inhibitor of GDNF/Ret, causes angiotensin II-induced ureteric bud branching
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Kidney Int 74:1287-93. 2008
    ..pathway for branching morphogenesis during kidney development is the c-Ret receptor tyrosine kinase whose ligand is GDNF and whose downstream target is Wnt11...
  21. pmc Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos
    Alexandre Gonçalves
    Developmental Genetics, Department of Biomedicine, University of Basel Medical Faculty, Basel, Switzerland
    PLoS ONE 6:e19370. 2011
    ..Therefore, we investigated whether BMP7 in turn also participates in inhibiting ureteric bud outgrowth during the initiation of metanephric kidney development...
  22. ncbi Persephin, a novel neurotrophic factor related to GDNF and neurturin
    J Milbrandt
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 20:245-53. 1998
    A novel neurotrophic factor named Persephin that is approximately 40% identical to glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) has been identified using degenerate PCR...
  23. pmc Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase
    S L Bullock
    Laboratory of Mammalian Development, Medical Research Council MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Genes Dev 12:1894-906. 1998
    ..These data provide the first genetic evidence that the regulated synthesis of differentially glycosylated proteoglycans can affect morphogenesis during vertebrate development...
  24. ncbi Regulation of metanephric kidney development by growth/differentiation factor 11
    Aurora F Esquela
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 257:356-70. 2003
    ..embryos lacking a ureteric bud was found to be defective in the expression of glial cell line-derived neurotrophic factor (Gdnf), a gene known to direct ureteric bud outgrowth...
  25. ncbi Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis
    Odysse Michos
    Developmental Genetics, Dept of Clinical Biological Sciences DKBW University of Basel Medical School, c o Anatomy Institute, Pestalozzistrasse 20, CH 4056 Basel, Switzerland
    Development 131:3401-10. 2004
    ..to induce metanephric kidney development as initiation of ureter growth, branching and establishment of RET/GDNF feedback signaling are disrupted in Grem1-deficient embryos...
  26. ncbi The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter
    Stephan Brodbeck
    Institut für Toxikologie und Genetik, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
    Mech Dev 121:1211-22. 2004
    ..One important molecule mediating this interaction is the glial cell line-derived neurotrophic factor Gdnf, which is secreted by the mesenchymal cells. Regulation of Gdnf expression is largely unknown...
  27. ncbi Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development
    Jennifer Whitehead
    Department of Pathology Neuropathology, Northwestern University, Chicago, IL 60611, USA
    Mech Dev 122:27-41. 2005
    Glial cell-line derived neurotrophic factor (GDNF) is a potent survival factor for motor neurons...
  28. ncbi GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    L F Lin
    Synergen, Inc, Boulder, CO 80301
    Science 260:1130-2. 1993
    A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned...
  29. ncbi Renal agenesis and the absence of enteric neurons in mice lacking GDNF
    M P Sanchez
    Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Nature 382:70-3. 1996
    Glial-cell-line-derived neurotrophic factor (GDNF) is a potent survival factor for dopaminergic neurons and motor neurons in culture...
  30. ncbi Defects in enteric innervation and kidney development in mice lacking GDNF
    J G Pichel
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda 20892, USA
    Nature 382:73-6. 1996
    Glial-lial-cell-line-derived neurotrophic factor (GDNF) has been isolated as neurotrophic factor for midbrain dopaminergic neurons...
  31. ncbi Renal and neuronal abnormalities in mice lacking GDNF
    M W Moore
    Department of Molecular Biology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 382:76-9. 1996
    Glial cell-line derived neurotrophic factor (GDNF) is a potent survival factor for embryonic midbrain dopaminergic, spinal motor, cranial sensory, sympathetic, and hindbrain noradrenergic neurons, and is available to these cells in vivo...
  32. ncbi Defects of urogenital development in mice lacking Emx2
    N Miyamoto
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Honjo, Japan
    Development 124:1653-64. 1997
    ..Pax-2 and c-ret expressions in the Wolffian duct and WT-1 and GDNF expressions in the metanephric blastema were initially normal in the mutant...
  33. ncbi GDNF induces branching and increased cell proliferation in the ureter of the mouse
    C V Pepicelli
    Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 192:193-8. 1997
    The secreted signaling molecule GDNF is expressed in the metanephric mesenchyme and has recently been implicated as a factor necessary for development of the metanephric kidney...
  34. ncbi Synergistic effects of schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1)
    V Arce
    Institut National de la Santé et de la Recherche Médicale INSERM U 382, Marseille, France
    J Neurosci 18:1440-8. 1998
    ..5 rat motoneurons in culture. Different lines of evidence implicate glial cell line-derived neurotrophic factor (GDNF) and cardiotrophin-1 (CT-1) in this synergy...
  35. ncbi Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development
    S Srinivas
    Department of Genetics and Development and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Development 126:1375-86. 1999
    ..kinase RET and co-receptor GFR(&agr;)-1, which are expressed in the ureteric bud, and the secreted ligand GDNF produced in the mesenchyme...
  36. ncbi Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud
    M J Donovan
    Department of Pathology, Children s Hospital, Boston, MA 02115, USA
    Dev Genet 24:252-62. 1999
    ..Here, we demonstrate that several markers, including Pax-2, Six-2, and GDNF, were present as RNAs in the metanephric mesenchyme of Wt1 -/- embryos...
  37. ncbi Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia
    P X Xu
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 23:113-7. 1999
    ..b>Gdnf expression, which is required to direct ureteric bud outgrowth via activation of the c-ret Rtk (refs 5, 6, 7, 8), ..
  38. ncbi Regulation of cell fate decision of undifferentiated spermatogonia by GDNF
    X Meng
    Research Programs of Developmental Biology, Molecular Neurobiology, Electron Microscopy Unit, Institute of Biotechnology, Viikki Biocenter, Finland
    Science 287:1489-93. 2000
    ..Transgenic loss-of-function and overexpression models now show that the dosage of glial cell line-derived neurotrophic factor (GDNF), produced by Sertoli cells, regulates cell fate decisions of undifferentiated spermatogonial cells ..
  39. ncbi Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract
    T Kume
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 127:1387-95. 2000
    ..Moreover, expression in the intermediate mesoderm of Glial cell-derived neurotrophic factor (Gdnf), a primary inducer of the ureteric bud, is expanded more anteriorly in Foxc1 homozygous mutants ..
  40. pmc Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter
    Y Miyazaki
    Department of Pediatrics, Department of Pathology, Department of Cell Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 105:863-73. 2000
    ..not inhibited, BMP4 beads inhibit ureter branching and expression of Wnt 11, a target of glial cell-derived neurotrophic factor signaling. Thus, Bmp4 has 2 functions in the early morphogenesis of the kidney and urinary tract...
  41. ncbi Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin
    H Enomoto
    Department of Pathology and Internal Medicine, Washington University School of Medicine, Box 8118, St Louis, MO 63110, USA
    Development 127:4877-89. 2000
    ..Here we show that GDNF signaling via the RET/GFR(alpha)1 complex is crucial for the development of cranial parasympathetic ganglia ..
  42. ncbi Promoter analysis and characteristics of the 5'-untranslated region of the mouse glial cell line-derived neurotrophic factor gene
    M Tanaka
    Laboratory for Genes of Motor Systems, Bio Mimetic Control Research Program, The Institute of Physical and Chemical Research RIKEN, Moriyama, Nagoya 463 0003, Japan
    Brain Res Mol Brain Res 85:91-102. 2000
    We have cloned the mouse GDNF cDNA and genomic DNA to study the molecular mechanism of gene expression...
  43. ncbi Nephron endowment in glial cell line-derived neurotrophic factor (GDNF) heterozygous mice
    L A Cullen-McEwen
    Department of Anatomy and Cell Biology, Department of Medicine, Monash University, Clayton, Victoria, Australia
    Kidney Int 60:31-6. 2001
    ..However, in vivo and in vitro evidence indicates that glial cell line-derived neurotrophic factor (GDNF) is a key regulator of the initiation of ureteric branching...
  44. ncbi Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development
    R Nishinakamura
    Division of Stem Cell Regulation, Institute of Medical Science, The University of Tokyo, Japan
    Development 128:3105-15. 2001
    ..Sall1 is therefore essential for ureteric bud invasion, the initial key step for metanephros development...
  45. ncbi Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene
    P D Brophy
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Development 128:4747-56. 2001
    ..The receptor tyrosine kinase RET and glial cell-derived neurotrophic factor (GDNF) form a signaling complex that is essential for ureteric bud growth and branching morphogenesis of ..
  46. ncbi Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret
    Ekatherina Batourina
    Department of Urology, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nat Genet 32:109-15. 2002
    ..Our studies indicate that formation of the trigonal wedge may be essential for correct insertion of the distal ureters into the bladder, and that these events are mediated by the vitamin A and Ret signaling pathways...
  47. ncbi GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools
    Georg Haase
    INSERM U 382, Developmental Biology Institute of Marseille, CNRS INSERM Univ Mediterranee, Campus de Luminy, Case 907, Marseille, France
    Neuron 35:893-905. 2002
    ..We show that glial cell line-derived neurotrophic factor (GDNF), initially characterized for its role as a survival factor, is present early in the plexus of the ..
  48. pmc Six1 is required for the early organogenesis of mammalian kidney
    Pin Xian Xu
    McLaughlin Research Institute, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 130:3085-94. 2003
    ..These analyses establish a role for Six1 in the initial inductive step for metanephric development...
  49. ncbi Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
    Arindam Majumdar
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 130:3175-85. 2003
    ..Wnt11 functions, in part, by maintaining normal expression levels of the gene encoding glial cell-derived neurotrophic factor (Gdnf)...
  50. ncbi Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development
    Lijun Chi
    Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, PO Box 3000, FIN 90014 Oulu, Finland
    Development 131:3345-56. 2004
    ..The experimentally induced dysmorphology associated with deregulated expression of Wnt11, Gdnf and Fgf7 genes in the early stages of organogenesis indicated a crucial role for sprouty function in coordination ..
  51. pmc Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut
    Ming Fu
    Department of Surgery, The University of Hong Kong, 21 Sassoon Rd, Pokfulam, Hong Kong, HKSAR China
    J Cell Biol 166:673-84. 2004
    ..The pro-neurogenic effect of glial cell line--derived neurotrophic factor (GDNF) on NCCs was abolished by Shh...
  52. ncbi GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration
    Hideki Enomoto
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 44:623-36. 2004
    The GDNF family ligands signal through a receptor complex composed of a ligand binding subunit, GFRalpha, and a signaling subunit, the RET tyrosine kinase...
  53. ncbi Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction
    M Albert Basson
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, USA
    Dev Cell 8:229-39. 2005
    ..These defects are due to increased sensitivity of the Wolffian duct to GDNF/RET signaling, and reducing Gdnf gene dosage correspondingly rescues the Spry1 null phenotype...
  54. ncbi GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons
    Esther Pozas
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S 17177 Stockholm, Sweden
    Neuron 45:701-13. 2005
    ..b>GDNF signaling via GFRalpha1 was found to promote the differentiation of ventral precursors into GABAergic cells, ..
  55. ncbi The role of GDNF in patterning the excretory system
    Reena Shakya
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Biol 283:70-84. 2005
    ..factors thought to play a critical role in patterning the growth and branching of the epithelial ureteric bud is GDNF. We have tested the requirement for GDNF as a paracrine chemoattractive factor by altering its site of expression ..
  56. ncbi FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons
    Uta Grieshammer
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
    Development 132:3847-57. 2005
    ..Thus, unlike other FGF family members, which regulate growth and branching morphogenesis of the collecting duct system, Fgf8 encodes a factor essential for gene regulation and cell survival at distinct steps in nephrogenesis...
  57. ncbi Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
    Thomas J Carroll
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 9:283-92. 2005
    ..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
  58. ncbi Lim 1 is required for nephric duct extension and ureteric bud morphogenesis
    Anissa Pedersen
    Department of Genetics, Cell Biology and Development and University of Minnesota Developmental Biology Center, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Dev Biol 288:571-81. 2005
    ..These results suggest that Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining the differentiation of the nephric epithelium...
  59. ncbi Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate
    Cathy K Naughton
    Division of Urology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Reprod 74:314-21. 2006
    ..We report that glial cell-line-derived neurotrophic factor (GDNF) signaling through the RET tyrosine kinase/GFRA1 receptor complex is required for spermatogonial self-..
  60. ncbi Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney
    David Grote
    McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Development 133:53-61. 2006
    ..Together, these results define Gata3 as a key regulator of nephric duct morphogenesis and guidance in the pro/mesonephric kidney...
  61. ncbi Spatial gene expression in the T-stage mouse metanephros
    Georgina Caruana
    Department of Anatomy and Cell Biology, Monash University, Clayton, Vic, Australia
    Gene Expr Patterns 6:807-25. 2006
    ..This study has identified genes spatially expressed in regions of the developing kidney involved in branching morphogenesis, nephrogenesis and the development of the collecting duct system, calyces, renal pelvis and ureter...
  62. ncbi Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1
    M Albert Basson
    Division of Hematology Oncology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 299:466-77. 2006
    ..Glial cell line-derived neurotrophic factor (GDNF) initiates ureteric bud formation and promotes subsequent branching morphogenesis...
  63. pmc Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
    Michelle Self
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    EMBO J 25:5214-28. 2006
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  64. ncbi Target-induced transcriptional control of dendritic patterning and connectivity in motor neurons by the ETS gene Pea3
    Eline Vrieseling
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Cell 127:1439-52. 2006
    ..We provide genetic evidence that the induction of the ETS transcription factor Pea3 by GDNF is essential in two cervical MN pools to control dendrite patterning and selectivity of IaPA connectivity...
  65. pmc Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation
    Laura Braydich-Stolle
    Department of Biology, The University of Dayton, Dayton, OH 45469, USA
    Dev Biol 304:34-45. 2007
    ..In this report, we studied some of the signaling pathways triggered by glial cell line-derived neurotrophic factor (GDNF), a component of the spermatogonial stem cell niche produced by the somatic Sertoli cells...
  66. pmc The lectin Dolichos biflorus agglutinin is a sensitive indicator of branching morphogenetic activity in the developing mouse metanephric collecting duct system
    Lydia Michael
    Centre for Integrative Physiology, Edinburgh University College of Medicine, Edinburgh, UK
    J Anat 210:89-97. 2007
    ..kidneys is inhibited in organ culture, by blocking the kidney's endogenous glial cell-derived neurothrophic factor (GDNF)-based branch-promoting signals, the DBA-binding zone extends to the very end of the tip but is lost from there ..
  67. ncbi Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney
    Melina Narlis
    McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    J Am Soc Nephrol 18:1121-9. 2007
    ..At the ureter tips, the expression of Wnt11, a target of glial cell-derived neurotrophic factor-Ret signaling, is significantly reduced, whereas the expression levels of Ret and GDNF remain normal...
  68. ncbi Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis
    Odysse Michos
    Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 134:2397-405. 2007
    ..All epithelial buds express Wnt11, and Gdnf is significantly upregulated in the surrounding mesenchyme, indicating that epithelial-mesenchymal (e-m) feedback ..
  69. pmc The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression
    James M Linton
    Department of Physiology, 1550 Fourth Street, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 134:2501-9. 2007
    ..Instead, we found that Gdnf expression was dramatically reduced in both nephronectin- and alpha8 integrin-null mutants specifically in the ..
  70. ncbi Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance
    Liz Simon
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 2001 S Lincoln Ave, Urbana, IL 61802, USA
    Exp Cell Res 313:3090-9. 2007
    Ets variant gene 5 (ETV5) and glial cell-derived neurotrophic factor (GDNF) are produced in Sertoli cells and required for maintenance and self-renewal of spermatogonial stem cells (SSCs) in mice...
  71. pmc Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling
    Jon M Oatley
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:25842-51. 2007
    ..SSC self-renewal is dependent on glial cell line-derived neurotrophic factor (GDNF); however, intracellular mechanisms stimulated by GDNF in SSCs are unknown...
  72. ncbi Glial cell-derived neurotrophic factor independent ureteric bud outgrowth from the Wolffian duct
    Akito Maeshima
    Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0693, USA
    J Am Soc Nephrol 18:3147-55. 2007
  73. doi Canonical WNT/beta-catenin signaling is required for ureteric branching
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 317:83-94. 2008
    ..Together, these data demonstrate that beta-catenin performs essential functions during renal branching morphogenesis via control of a hierarchy of genes that control ureteric branching...
  74. doi Development of satellite glia in mouse sympathetic ganglia: GDNF and GFR alpha 1 are not essential
    Thomas Callahan
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria 3010, Australia
    Glia 56:1428-37. 2008
    ..Satellite glial precursors in E11.5-E15.5 mice also expressed the GDNF-binding molecule, GFRalpha1...
  75. pmc Role of fibroblast growth factor receptor 2 in kidney mesenchyme
    David Hains
    Center for Cell and Developmental Biology, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Pediatr Res 64:592-8. 2008
    ..Deletion of Fgfr2 did not change expression domains of glial cell line-derived neurotrophic factor (GDNF), Robo2, bone morphogenetic protein 4, or Sprouty1, all of which regulate ureteric bud induction...
  76. pmc The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding
    Vimal Parkash
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Biol Chem 283:35164-72. 2008
    Glial cell line-derived neurotrophic factor (GDNF), a neuronal survival factor, binds its co-receptor GDNF family receptor alpha1 (GFR alpha 1) in a 2:2 ratio and signals through the receptor tyrosine kinase RET...
  77. doi Biosynthesis, processing, and secretion of glial cell line-derived neurotrophic factor in astroglial cells
    Kentaro Oh-Hashi
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, 1 1 Yanagido, Gifu, 501 1193, Japan
    Mol Cell Biochem 323:1-7. 2009
    Glial cell line-derived neurotrophic factor (GDNF) is synthesized as a precursor, proGDNF...
  78. pmc Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome
    Courtney M Karner
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e10418. 2010
    ..Multiple signaling pathways must be integrated to ensure proper timing and location of the ureteric bud formation...
  79. pmc Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney
    Vidya K Nagalakshmi
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Kidney Int 79:317-30. 2011
    ..Furthermore, an understanding of miRNA action may provide new insights into the etiology and pathogenesis of renal cyst-based kidney disease...
  80. doi Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney
    Nina Perälä
    Institute of Biomedicine Medical Biochemistry and Developmental Biology, Biomedicum Helsinki, PO Box 63, FI 00014 University of Helsinki, Finland
    Differentiation 81:81-91. 2011
    ..Plexin B2 interacts with the Ret receptor tyrosine kinase, the receptor of Glial-cell-line-derived neurotrophic factor (Gdnf), in embryonic kidneys...
  81. pmc Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development
    Courtney M Karner
    Department of Internal Medicine Nephrology and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Dallas, TX 75390, USA
    Development 138:1247-57. 2011
    ..These findings provide novel insights into the molecular mechanisms that regulate progenitor cell differentiation during normal and pathological conditions...
  82. pmc Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice
    Masato Hoshi
    Department of Internal Medicine Renal Division, Washington University School ofMedicine, St Louis, MO 63110, USA
    Development 139:2405-15. 2012
    ..We show that the mechanism of de novo ectopic budding is via increased ERK activity due to abnormal mesenchymal GDNF expression. Although reduction in GDNF dosage improved CAKUT it did not affect delayed mesenchyme regression...
  83. pmc Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesoderm
    Aki Murashima
    Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Wakayama, Japan
    Dev Biol 386:216-26. 2014
    ..These data demonstrate the essential role of midline-derived Shh in local tissue morphogenesis and differentiation. ..
  84. pmc Hox11 paralogous genes are essential for metanephric kidney induction
    Deneen M Wellik
    Department of Human Genetics and Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City 84112 5331, USA
    Genes Dev 16:1423-32. 2002
    ..Six2 expression, however, is absent, as is expression of the inducing growth factor, Gdnf. In the absence of Gdnf, ureteric bud formation is not initiated...
  85. ncbi Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb
    Edgar R Kramer
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    Neuron 50:35-47. 2006
    ..Here, we implicate glial-cell-line-derived neurotrophic factor (GDNF) and its receptor, Ret, in the same guidance decision...
  86. pmc Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo
    Joshua W Mugford
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 319:396-405. 2008
    ..This program maintains tubule forming progenitors and instructs a metanephric specific pattern of nephron differentiation...
  87. doi Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8
    Francisco Barrionuevo
    Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Dev Biol 327:301-12. 2009
    ..This study shows that testis cord differentiation is independent of Sox9, and that concerted Sox9 and Sox8 function in post E14.0 Sertoli cells is essential for the maintenance of testicular function...
  88. pmc c-RET molecule in malignant melanoma from oncogenic RET-carrying transgenic mice and human cell lines
    Yuichiro Ohshima
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai shi, Aichi, Japan
    PLoS ONE 5:e10279. 2010
    ..In this study, we showed that expression levels of intrinsic c-Ret, glial cell line-derived neurotrophic factor (Gdnf) and Gdnf receptor alpha 1 (Gfra1) transcripts in malignant melanomas from RET-transgenic mice were ..
  89. ncbi Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions
    H L Hellmich
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892 4090, USA
    Mech Dev 54:95-105. 1996
    We describe the cloning of the mouse glial cell line-derived neurotrophic factor (GDNF) gene and its expression during embryogenesis...
  90. ncbi TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret
    R H Baloh
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 18:793-802. 1997
    Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) comprise a family of TGF-beta-related neurotrophic factors (TRNs), which have trophic influences on a variety of neuronal populations...
  91. ncbi Prominent expression of glial cell line-derived neurotrophic factor in human skeletal muscle
    H Suzuki
    Department of Pharmacology, Nippon Medical School, Tokyo, Japan
    J Comp Neurol 402:303-12. 1998
    Glial cell line-derived neurotrophic factor (GDNF) has been shown to exert neurotrophic effects on motor neurons as well as mesencephalic dopaminergic neurons...
  92. ncbi Lessons from genetically engineered animal models. II. Disorders of enteric neuronal development: insights from transgenic mice
    M D Gershon
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Am J Physiol 277:G262-7. 1999
    ..The second, associated with mutations in genes encoding glial cell line-derived neurotrophic factor (GDNF), its preferred receptor GFRalpha1, or their signaling component, Ret, appears to deprive a GDNF-..
  93. ncbi Development of interstitial cells of Cajal and pacemaking in mice lacking enteric nerves
    S M Ward
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, USA
    Gastroenterology 117:584-94. 1999
    ..Kit is activated by stem cell factor (SCF), but the source of SCF in the bowel wall is unclear and controversy exists about whether enteric neurons express the SCF required for ICC development...
  94. pmc New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control
    N V Botchkareva
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    Am J Pathol 156:1041-53. 2000
    Glial cell line-derived neurotrophic factor (GDNF), neurturin (NTN), and their receptors, GDNF family receptor alpha-1 (GFRalpha-1) and GDNF family receptor alpha-2 (GFRalpha-2), are critically important for kidney and nervous system ..
  95. ncbi A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development
    A Mikaels
    Laboratory of Molecular Neurobiology, MBB, Karolinska Institute, S171 77 Stockholm, Sweden
    Eur J Neurosci 12:446-56. 2000
    Glial cell line-derived neurotrophic factor (GDNF) family ligands promote the survival of developing motor neurons in vivo and in vitro...
  96. ncbi Functional analysis of zebrafish GDNF
    I T Shepherd
    Department of Biological Structure, University of Washington, Seattle, Washington 98195, USA
    Dev Biol 231:420-35. 2001
    We have identified zebrafish orthologues of glial cell line-derived neurotrophic factor (GDNF) and the ligand-binding component of its receptor GFRalpha1...
  97. ncbi Marked dopaminergic cell loss subsequent to developmental, intranigral expression of glial cell line-derived neurotrophic factor
    Hong S Chun
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University at the W M Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, New York 10605, USA
    Exp Neurol 173:235-44. 2002
    Glial cell line-derived neurotrophic factor (GDNF) shows potent neuroprotective as well as neurorestorative actions on the adult neurons impacted in animal models of Parkinson's disease (PD)...
  98. ncbi GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults
    Rose Hanbury
    Research Center for Brain Repair and Department of Neurological Sciences, Rush Presbyterian Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 461:307-16. 2003
    ..Enzyme-linked immunoassay analysis revealed increased basal levels of glial cell derived neurotrophic factor (GDNF) relative to WT mice...
  99. ncbi Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons
    Pontus C Holm
    Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm S 171 77, Sweden
    Development 130:3535-45. 2003
    The role of glial cell-line derived neurotrophic factor (GDNF) and neurotrophins in the development of locus coeruleus noradrenergic neurons was evaluated...
  100. ncbi Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion
    Woong Sun
    Department of Neurobiology and Anatomy, and Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 23:7298-310. 2003
    ..is responsible for postnatal MN atrophy and loss of innervation, we applied glial cell line-derived neurotrophic factor (GDNF) to neonatal mice...
  101. ncbi Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1
    Hong Zhang
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Curr Biol 13:1625-9. 2003
    ..The contribution of PlGF toward stromal signals that regulate epithelial differentiation suggests novel functions for a growth factor previously implicated in reactive angiogenesis...

Research Grants6

  1. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2001
    ..Finally, new types of mutants and transgenic mice will be generated to study the role of Fused in mouse embryogenesis. ..
  2. The Role of RET in Spermatogenesis
    Cathy Naughton; Fiscal Year: 2005
    ..The translation to human disease will be achieved by studying RET expression in male infertility cases of maturation arrest. ..
  3. Optimizing Testis Transplantation to Study RET Signaling
    Cathy Naughton; Fiscal Year: 2005
    ..Determining how Ret affects testicular function will add to our understanding of human male infertility and may provide an avenue for new treatment strategies for infertile men with nonobstructive azoospermia. ..
  4. Transcription Factor P53 in Terminal Nephron Different
    Zubaida Saifudeen; Fiscal Year: 2004
    ..The results of this work will provide information on what determines terminal renal differentiation. In addition, these data will advance our understanding of the role the tumor suppressor p53 in kidney development...
  5. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2007
    ..abstract_text> ..
  6. Mitochondrial Dysfunction in Down's Syndrome
    JORGE A BUSCIGLIO; Fiscal Year: 2010
    ..DS that may be critical to understand the role of energy impairment in neurodegenerativedisorders, and to design therapies directed to prevent neuronal dysfunction and the progression of AD neuropathology in DS patients ..