Gcg

Summary

Gene Symbol: Gcg
Description: glucagon
Alias: GLP-1, Glu, PPG, glucagon, glucagon-like peptide I
Species: mouse

Top Publications

  1. pmc Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Diabetes 59:1030-7. 2010
  2. pmc Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
    Helga Ellingsgaard
    Clinic for Endocrinology, Diabetes and Metabolism and Department Biomedicine, University Hospital Basel, Basel, Switzerland
    Nat Med 17:1481-9. 2011
  3. doi Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    Lotte Bjerre Knudsen
    Department of Biology and Pharmacology Mgt, Novo Nordisk A S, Novo Nordisk Park, Maaloev DK 2760, Denmark
    Endocrinology 151:1473-86. 2010
  4. pmc GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells
    Julie Quoyer
    INSERM, U661, Equipe Avenir, CNRS, UMR5203, Institut de Genomique Fonctionnelle, Université Montpellier I and II, 34094 Montpellier Cedex 5, France
    J Biol Chem 285:1989-2002. 2010
  5. doi Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor
    Kiwon Ban
    TMDT 3 904, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Endocrinology 151:1520-31. 2010
  6. ncbi Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
    Laurie L Baggio
    Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Ontario, Canada
    Gastroenterology 127:546-58. 2004
  7. ncbi The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
  8. pmc Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development
    Jingxuan Liu
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:15352-60. 2011
  9. doi Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells
    Yoshitaka Hayashi
    Department of Genetics, Research Institute of Environmental Medicine, Nagoya University, Japan
    Mol Endocrinol 23:1990-9. 2009
  10. doi Minireview: update on incretin biology: focus on glucagon-like peptide-1
    Patricia L Brubaker
    Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada
    Endocrinology 151:1984-9. 2010

Research Grants

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  2. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
  3. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007
  4. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  5. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
  6. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
  7. Foxm 1b endocrine pancreas growth and regeneration
    Maureen Gannon; Fiscal Year: 2009
  8. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
  9. HNF6 Function in the Pancreatic Endocrine Lineage
    Maureen A Gannon; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications172 found, 100 shown here

  1. pmc Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Diabetes 59:1030-7. 2010
    Exogenous administration of glucagon-like peptide-1 (GLP-1) or GLP-1 receptor agonists such as an exendin-4 has direct beneficial effects on the cardiovascular system. However, their effects on atherosclerogenesis have not been elucidated...
  2. pmc Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
    Helga Ellingsgaard
    Clinic for Endocrinology, Diabetes and Metabolism and Department Biomedicine, University Hospital Basel, Basel, Switzerland
    Nat Med 17:1481-9. 2011
    Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone that induces insulin secretion...
  3. doi Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    Lotte Bjerre Knudsen
    Department of Biology and Pharmacology Mgt, Novo Nordisk A S, Novo Nordisk Park, Maaloev DK 2760, Denmark
    Endocrinology 151:1473-86. 2010
    Liraglutide is a glucagon-like peptide-1 (GLP-1) analog developed for type 2 diabetes. Long-term liraglutide exposure in rodents was associated with thyroid C-cell hyperplasia and tumors...
  4. pmc GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells
    Julie Quoyer
    INSERM, U661, Equipe Avenir, CNRS, UMR5203, Institut de Genomique Fonctionnelle, Université Montpellier I and II, 34094 Montpellier Cedex 5, France
    J Biol Chem 285:1989-2002. 2010
    ..Such signaling mechanism may serve as a prototype to generate new therapeutic GLP-1R ligands...
  5. doi Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor
    Kiwon Ban
    TMDT 3 904, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Endocrinology 151:1520-31. 2010
    The widely expressed dipeptidyl peptidase-4 enzyme rapidly cleaves the gut hormone glucagon-like peptide-1 [GLP-1(7-36)amide] at the N terminus to generate GLP-1(9-36)amide...
  6. ncbi Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
    Laurie L Baggio
    Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Ontario, Canada
    Gastroenterology 127:546-58. 2004
    Gut-derived peptides including ghrelin, cholecystokinin (CCK), peptide YY (PYY), glucagon-like peptide (GLP-1), and GLP-2 exert overlapping actions on energy homeostasis through defined G-protein-coupled receptors (GPCRs)...
  7. ncbi The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
    ..Finally, our data provide evidence that both Arx and Pax4 act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation...
  8. pmc Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development
    Jingxuan Liu
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:15352-60. 2011
    ..This cell type produces glucagon, a major counteracting hormone to insulin in regulating glucose homeostasis in adults...
  9. doi Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells
    Yoshitaka Hayashi
    Department of Genetics, Research Institute of Environmental Medicine, Nagoya University, Japan
    Mol Endocrinol 23:1990-9. 2009
    Multiple bioactive peptides, including glucagon, glucagon-like peptide-1 (GLP-1), and GLP-2, are derived from the glucagon gene (Gcg)...
  10. doi Minireview: update on incretin biology: focus on glucagon-like peptide-1
    Patricia L Brubaker
    Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada
    Endocrinology 151:1984-9. 2010
    The incretin hormone, glucagon-like peptide-1 (GLP-1), is now being used in the clinic to enhance insulin secretion and reduce body weight in patients with type 2 diabetes...
  11. ncbi Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
    Abba J Kastin
    VA Medical Center, New Orleans, LA, USA
    J Mol Neurosci 18:7-14. 2002
    b>Glucagon-like peptide-1 (GLP-1) reduces insulin requirement in diabetes mellitus and promotes satiety. GLP-1 in the periphery (outside the CNS) has been shown to act on the brain to reduce food ingestion...
  12. ncbi Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development
    Jessica Dessimoz
    Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, Case Postale, CH 1066 Epalinges s Lausanne, Switzerland
    Curr Biol 15:1677-83. 2005
    ..These effects are likely to be due to the function of beta-catenin at the membrane. Mice later recover from pancreatitis and regenerate normal pancreas and duodenal villi from the wild-type (wt) cells that escape beta-catenin deletion...
  13. ncbi Stabilization of beta-catenin impacts pancreas growth
    Patrick W Heiser
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 133:2023-32. 2006
    ..Taken together, these data suggest a previously unappreciated temporal/spatial role for beta-catenin signaling in the regulation of pancreas organ growth...
  14. ncbi The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation
    Junfeng Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Dev Biol 266:178-89. 2004
    ..This role of Pax4 appears to be accomplished via its genetic interaction with another homeobox gene, Nkx2.2...
  15. ncbi Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
    Susumu Katsuma
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Biochem Biophys Res Commun 329:386-90. 2005
    ..In this study, we show that bile acids promote glucagon-like peptide-1 (GLP-1) secretion through TGR5 in a murine enteroendocrine cell line STC-1...
  16. ncbi Beta-catenin is essential for pancreatic acinar but not islet development
    L Charles Murtaugh
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 132:4663-74. 2005
    ..Thus, our data are consistent with a crucial role for canonical Wnt signals in acinar lineage specification and differentiation...
  17. pmc Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation
    Patricia M Vuguin
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10476, USA
    Endocrinology 147:3995-4006. 2006
    Although glucagon (GLU) plays a pivotal role in glucose homeostasis, its role in the regulation of fetal growth and maturation is poorly understood...
  18. pmc A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697 2300, USA
    Dev Biol 323:19-30. 2008
    ..Our findings therefore suggest that defective endocrine specification might underlie the pancreatic phenotype of individuals with CD...
  19. pmc Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas
    Sui Wang
    Program in Developmental Biology and Department of Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University Medical Center, 465 21st Avenue South, Rm 4128, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Dev Biol 339:26-37. 2010
    ..The control of Neurog3+ cell number and the Neurog3 threshold-dependent endocrine differentiation mechanism combine to select a specific proportion of pancreatic progenitor cells to adopt the islet cell fate...
  20. ncbi Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells
    F Reimann
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, UK
    Diabetologia 47:1592-601. 2004
    b>Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are secreted from enteroendocrine L cells in response to nutrient ingestion...
  21. ncbi Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1
    Y Rouille
    Laboratoires de Recherche Louis Jeantet, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 272:32810-6. 1997
    ..is processed differentially in pancreatic alpha-cells and intestinal endocrine L cells to release either glucagon or glucagon-like peptide-1-(7-36amide) (tGLP-1), two peptide hormones with opposing biological actions...
  22. ncbi Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal
    Claudio Acuna-Goycolea
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 24:8141-52. 2004
    b>Glucagon-like peptide 1 (GLP-1) is produced by neurons in the caudal brainstem that receive sensory information from the gut and project to several hypothalamic regions involved in arousal, interoceptive stress, and energy homeostasis...
  23. pmc Lack of TCF2/vHNF1 in mice leads to pancreas agenesis
    C Haumaitre
    Biologie du Développement, Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:1490-5. 2005
    ..This study provides further insights into early molecular events controlling pancreas development and may contribute to the development of cell-replacement strategies for diabetes...
  24. ncbi GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes
    Hong Gao
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
    Endocrine 32:90-5. 2007
    b>Glucagon-like peptide-1 (7-36) amide (GLP-1) is an insulin secretagogue. Recently, many studies have shown GLP-1 can improve insulin resistance in peripheral tissues...
  25. pmc Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2059-69. 2009
    ....
  26. pmc Pancreatic neurogenin 3-expressing cells are unipotent islet precursors
    Renaud Desgraz
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Development 136:3567-74. 2009
    ..We propose a model whereby Ngn3(+) cells are monotypic (i.e. unipotent) precursors, and use this paradigm to refocus ideas on how cell number and type must be regulated in building complete islets of Langerhans...
  27. pmc Rfx6 directs islet formation and insulin production in mice and humans
    Stuart B Smith
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 463:775-80. 2010
    ..These studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans. Rfx6 could prove useful in efforts to generate beta-cells for patients with diabetes...
  28. pmc Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate
    Kelli L VanDussen
    Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 346:215-23. 2010
    ..Thus, Math1 is a key effector directing multipotential precursors to adopt secretory and not absorptive cell fate...
  29. doi Antiapoptotic effects of GLP-1 in murine HL-1 cardiomyocytes
    Susana Ravassa
    Division of Cardiovascular Sciences, Center for Applied Medical Research, University Clinic, School of Medicine, University of Navarra, Pamplona, Spain
    Am J Physiol Heart Circ Physiol 300:H1361-72. 2011
    Activation of apoptosis contributes to cardiomyocyte dysfunction and death in diabetic cardiomyopathy. The peptide glucagon-like peptide-1 (GLP-1), a hormone that is the basis of emerging therapy for type 2 diabetic patients, has ..
  30. pmc Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
    ..2-deficient pancreata. Hence in order to precise the functional link between both factors we performed a comparative analysis of Nkx2.2/Arx single- and double-mutants but also of Pax6-deficient animals...
  31. pmc CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs
    Kazunari Hisadome
    Department of Surgery and Cancer, Imperial College London, London, UK
    Diabetes 60:2701-9. 2011
    b>Glucagon-like peptide 1 (GLP-1) is involved in the central regulation of food intake. It is produced within the brain by preproglucagon (PPG) neurons, which are located primarily within the brain stem...
  32. pmc Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides
    Chika Watanabe
    Department of Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
    Diabetes 61:74-84. 2012
    b>Glucagon is believed to be one of the most important peptides for upregulating blood glucose levels...
  33. doi Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice
    L Ahlkvist
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Regul Pept 178:29-35. 2012
    ..We therefore developed an oral mixed meal model in mice to 1) explore the glucagon-like peptide-1 (GLP-1) and islet hormone responses to mixed meal versus isocaloric glucose, and 2) characterize ..
  34. pmc Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
    Atsushi Suzuki
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Proc Natl Acad Sci U S A 100:5034-9. 2003
    b>Glucagon-like peptide (GLP) 1 is produced through posttranslational processing of proglucagon and acts as a regulator of various homeostatic events...
  35. ncbi Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
    M Sander
    Hormone Research Institute, University of California San Francisco, San Francisco, CA 94143 0534, USA
    Development 127:5533-40. 2000
    ..Together, these experiments reveal two independently controlled pathways for beta-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of beta-cell differentiation...
  36. ncbi Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice
    M Furuta
    Department of Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 276:27197-202. 2001
    ..Their islets show marked alpha (A)-cell hyperplasia, suggesting a possible defect in glucagon processing (Furuta, M., Yano, H., Zhou, A., Rouille, Y., Holst, J., Carroll, R., Ravazzola, M., Orci, L...
  37. ncbi cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells
    Edith Gomez
    Department of Biochemistry, University of Leicester, United Kingdom
    J Biol Chem 277:48146-51. 2002
    b>Glucagon like peptide-1 (GLP1) is a G(s)-coupled receptor agonist that exerts multiple effects on pancreatic beta-cells, including the stimulation of insulin gene expression and secretion...
  38. ncbi MicroRNA expression is required for pancreatic islet cell genesis in the mouse
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0534, USA
    Diabetes 56:2938-45. 2007
    ..We tested the hypothesis that microRNAs (miRNAs), which limit gene expression through posttranscriptional silencing, modulate the gene expression cascades involved in pancreas development...
  39. doi Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure
    Claude Knauf
    Institut de Medecine Moleculaire de Rangueil, Toulouse III University, Centre Hospitalier Universitaire Rangueil, BP84225, 31432 Toulouse Cedex 4, France
    Endocrinology 149:4768-77. 2008
    b>Glucagon-like peptide-1 (GLP-1) is a peptide released by the intestine and the brain. We previously demonstrated that brain GLP-1 increases glucose-dependent hyperinsulinemia and insulin resistance...
  40. pmc The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice
    Jennifer M Oliver-Krasinski
    Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 119:1888-98. 2009
    ....
  41. ncbi PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis
    Wei Zhang
    Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Cell Metab 4:491-7. 2006
    ....
  42. ncbi Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line
    F Lu
    Department of Medicine, Banting and Best Diabetes Center, Toronto Hospital, University of Toronto, Ontario, Canada
    Endocrinology 137:3710-6. 1996
    ..These observations identify GRP as a peptide activator of proglucagon gene expression and provide evidence linking the proglucagon gene CRE to the physiological control of proglucagon gene expression...
  43. pmc Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland
    Antonis Voutetakis
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Endocrinology 151:4566-72. 2010
    An adenoviral (Ad) vector that expresses bioactive glucagon-like peptide 1 (GLP-1) was generated, and its effectiveness at modulating glucose homeostasis was evaluated after transduction of murine salivary glands...
  44. pmc Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice
    Wataru Nishimura
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, USA
    Dev Biol 314:443-56. 2008
    ..deficiency, as manifest in the Pax6(Sey-Neu) allele, reduced not only the number of cells expressing insulin or glucagon, but also the number of MafB, PDX-1 and MafA expressing cells...
  45. ncbi Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro
    M E Rothenberg
    Department of Anatomy and Cell Biology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 270:10136-46. 1995
    ..4%, respectively. Immunohistochemical analyses with antibodies directed against PC2 and glucagon colocalized both the enzyme and substrate within the same secretory granules...
  46. ncbi Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice
    K Thomaseth
    Institute of Biomedical Engineering, Padua, Italy
    Am J Physiol Endocrinol Metab 292:E1808-14. 2007
    b>Glucagon-like peptide-1 (GLP-1) plays a significant role in glucose homeostasis through its incretin effect on insulin secretion...
  47. pmc Recovery from diabetes in mice by beta cell regeneration
    Tomer Nir
    Department of Cellular Biochemistry and Human Genetics, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Clin Invest 117:2553-61. 2007
    ..These results suggest that regenerative therapy for type 1 diabetes may be achieved if autoimmunity is halted using regeneration-compatible drugs...
  48. pmc Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis
    Shouhong Xuan
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    J Clin Invest 122:3516-28. 2012
    ....
  49. ncbi Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas
    Maria E Wilson
    UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0534, USA
    Mech Dev 115:171-6. 2002
    The earliest endocrine cells in the developing pancreas make glucagon and are described as alpha cells...
  50. ncbi Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors
    Xiaosong Ma
    Department of Molecular and Cellular Physiology, Diabetes Research Unit, Institute of Physiological Sciences, Biomedical Center B11 SE 221 84 Lund, Sweden
    Mol Endocrinol 19:198-212. 2005
    b>Glucagon, secreted by the pancreatic alpha-cells, stimulates insulin secretion from neighboring beta-cells by cAMP- and protein kinase A (PKA)-dependent mechanisms, but it is not known whether glucagon also modulates its own secretion...
  51. ncbi GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice
    Tanya Hansotia
    Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, and the University of Toronto, 200 Elizabeth Street MBRW4R 402, Toronto, Ontario, Canada M5G 2C4
    Regul Pept 128:125-34. 2005
    Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gut-derived incretins secreted in response to nutrient ingestion...
  52. ncbi Synergistic endocrine induction by GLP-1 and TGF-beta in the developing pancreas
    Eri Tei
    Laboratory of Surgical Organogenesis, Children s Mercy Hospital, Kansas City, MO, USA
    Pancreas 31:138-41. 2005
    b>Glucagon-like peptide-1 (GLP-1) is known to stimulate glucose-dependent insulin production and secretion by pancreatic beta-cells...
  53. pmc Modulation of taste sensitivity by GLP-1 signaling
    Yu Kyong Shin
    National Institute on Aging NIH, Baltimore, Maryland 21224, USA
    J Neurochem 106:455-63. 2008
    ..In this study, we report that glucagon-like peptide-1 (GLP-1) signaling in taste buds modulates taste sensitivity in behaving mice...
  54. pmc Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    Nan Gao
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Genes Dev 22:3435-48. 2008
    ..Thus, the regulation of Pdx1 expression by Foxa1 and Foxa2 is a key early event controlling the expansion and differentiation of the pancreatic primordia...
  55. ncbi Developmental biology of the pancreas
    J M Slack
    Department of Zoology, Oxford University, UK
    Development 121:1569-80. 1995
    ....
  56. ncbi IPF1, a homeodomain protein with a dual function in pancreas development
    J Jonsson
    Department of Microbiology, University of Umea, Sweden
    Int J Dev Biol 39:789-98. 1995
    ....
  57. ncbi Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
    A Bhushan
    INSERM 457, Hospital Robert Debre, 75019 Paris, France
    Development 128:5109-17. 2001
    ..These results indicate that Fgf10 signalling is required for the normal development of the pancreas and should prove useful in devising methods to expand pancreatic progenitor cells...
  58. ncbi Role of leptin in the regulation of glucagon-like peptide-1 secretion
    Younes Anini
    Department of Physiology, University of Toronto, Ontario, Canada
    Diabetes 52:252-9. 2003
    b>Glucagon-like peptide-1 (GLP-1), released from intestinal endocrine L cells, is a potent insulinotropic hormone. GLP-1 secretion is diminished in obese patients...
  59. ncbi Single-cell transcript analysis of pancreas development
    Ming Ko Chiang
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 4:383-93. 2003
    ..This form of single-cell transcriptional analysis can be applied to any developmental process or tissue to characterize distinct cell types...
  60. ncbi Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway
    Hongxiang Hui
    Division of Endocrinology and Metabolism, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocrinology 144:1444-55. 2003
    The activation of the glucagon-like peptide-1 (GLP-1) receptor has been shown to have an important role in the functional activity of islet beta-cells and in the expansion of the islet cell mass...
  61. ncbi FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development
    Gitte Anker Norgaard
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Dev Biol 264:323-38. 2003
    ..These data suggest that FGF10 signaling serves to integrate cell growth and terminal differentiation at the level of Notch activation, revealing a novel second role of this key signaling system during pancreatic development...
  62. ncbi The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
    R Scott Heller
    Department of Developmental Biology, Hagedorn Research Institute, DK 2820 Gentofte, Denmark
    Dev Biol 268:123-34. 2004
    ..and paired-homeodomain transcription factors, respectively, that are expressed in the brain and the glucagon-expressing cells in the pancreas...
  63. ncbi The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice
    Jennifer L Lachey
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237 0559, USA
    Endocrinology 146:458-62. 2005
    In rats, central administration of glucagon-like peptide-1 (GLP-1) elicits symptoms of visceral illness like those caused by the toxin lithium chloride (LiCl), including anorexia, conditioned taste aversion (CTA) formation, and neural ..
  64. pmc Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion
    Khoi Chu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Diabetes 54:1064-73. 2005
    ..These results suggest for the first time an important role for NNAT in insulin secretion and for proper beta-cell function...
  65. ncbi Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
    Junji Fujikura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cell Metab 3:59-65. 2006
    ..Thus, our analyses indicate that Notch/Rbp-j signaling prevents premature differentiation of pancreatic progenitor cells into endocrine and ductal cells during early development of the pancreas...
  66. ncbi The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass
    Hongjie Zhang
    Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Endocrinol 20:1853-66. 2006
    ..These results suggest that mechanisms regulating embryonic beta-cell proliferation differ from those used postnatally to maintain the differentiated cell population...
  67. ncbi The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3
    Yanwen Xu
    Vanderbilt University, Department of Cell and Developmental Biology, Nashville, TN 37232, USA
    Dev Biol 297:340-9. 2006
    ..These results suggest that Mfng-mediated repression of Notch signaling could serve as a trigger for endocrine islet differentiation...
  68. doi Amelioration of hyperglycemia by intestinal overexpression of glucagon-like peptide-1 in mice
    Meng Ju Liu
    Rosalind Franklin Comprehensive Diabetes Center, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Mol Med (Berl) 88:351-8. 2010
    To investigate whether the local production of glucagon-like peptide-1 (GLP-1) in the intestine can differentiate intestinal stem/progenitor cells into insulin-producing cells, we intra-intestinally injected a recombinant adenovirus ..
  69. ncbi Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene
    P L Herrera
    Institute of Histology and Embryology, University of Geneva Medical School, Switzerland
    Development 113:1257-65. 1991
    By immunofluorescence on cytospin preparations and on semithin sections of mouse pancreatic buds, we have found glucagon and pancreatic polypeptide (PP)-containing cells at embryonal day 10.5 (E 10.5) in dorsal buds and at E 11...
  70. ncbi Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    Y Guz
    Department of Anatomy and Cell Biology, SUNY Health Science Center at Brooklyn 11203
    Development 121:11-8. 1995
    ....
  71. ncbi PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
    M F Offield
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 122:983-95. 1996
    ..This outgrowth does not contain insulin or amylase-positive cells, but glucagon-expressing cells are found...
  72. ncbi The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
    B Sosa-Pineda
    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Nature 386:399-402. 1997
    ..The four endocrine cell types found in the adult pancreas-(alpha, beta, delta and PP-synthesize glucagon, insulin, somatostatin and pancreatic polypeptide, respectively...
  73. ncbi Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
    A Apelqvist
    Department of Microbiology, University of Umea, Sweden
    Curr Biol 7:801-4. 1997
    ..These results provide evidence that the differential expression of endodermally derived Shh controls the fate of adjacent mesoderm at different regions of the gut tube...
  74. ncbi Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
    L Sussel
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Development 125:2213-21. 1998
    ..Immunohistochemical analysis reveals that the mutant embryos lack insulin-producing beta cells and have fewer glucagon-producing alpha cells and PP cells...
  75. ncbi Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
    K A Harrison
    Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 23:71-5. 1999
    ..Hlxb9-/- beta-cells express low levels of the glucose transporter Glut2 and homeodomain factor Nkx 6-1. Thus, Hlxb9 is key to normal pancreas development and function...
  76. ncbi Notch signalling controls pancreatic cell differentiation
    A Apelqvist
    Department of Microbiology, University of Umea, Sweden
    Nature 400:877-81. 1999
    ..These data provide evidence that ngn3 acts as proendocrine gene and that Notch signalling is critical for the decision between the endocrine and progenitor/exocrine fates in the developing pancreas...
  77. ncbi The glucagon-like peptides
    T J Kieffer
    Department of Medicine, University of Alberta, Edmonton, Canada
    Endocr Rev 20:876-913. 1999
  78. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
    ..We show herein that ngn3-positive cells coexpress neither insulin nor glucagon, suggesting that ngn3 marks early precursors of pancreatic endocrine cells...
  79. ncbi Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation
    J Jensen
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 49:163-76. 2000
    ..notion that both alpha- and beta-cells develop independently from PDX1+/Ngn3+ epithelial cells, rather than from GLU+/INS+ intermediate stages...
  80. ncbi Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
    V M Schwitzgebel
    Hormone Research Institute, Department of Pediatrics, and Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Development 127:3533-42. 2000
    ....
  81. pmc Activin receptor patterning of foregut organogenesis
    S K Kim
    Department of Developmental Biology, Stanford University, Stanford, California 94305 5329 USA
    Genes Dev 14:1866-71. 2000
    ..Thus, activin receptor-mediated signaling regulates axial patterning, cell differentiation, and function of foregut-derived organs...
  82. ncbi The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells
    Mari Anne Pulkkinen
    Biomedicum Helsinki, Program for Developmental and Reproductive Biology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mech Dev 120:167-75. 2003
    ..Our results thus suggest that Fgfr2b-mediated signaling plays a major role in pancreatic ductal proliferation and branching morphogenesis, but has little effect on endocrine and exocrine differentiation...
  83. ncbi Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development
    Jacob Hald
    Department of Developmental Biology, Hagedorn Research Institute, Niels Steensensvej 6, DK 2820 Gentofte, Denmark
    Dev Biol 260:426-37. 2003
    ....
  84. pmc Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
    ..We propose that the antagonistic functions of Arx and Pax4 for proper islet cell specification are related to the pancreatic levels of the respective transcripts...
  85. pmc Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development
    Catherine L Prado
    Department of Pediatrics, Barbara Davis Center, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:2924-9. 2004
    ..2 is essential for the differentiation of all insulin-producing beta cells and a subset of glucagon-producing alpha cells (1). Mice lacking Nkx2...
  86. ncbi Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
    David A Cano
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 131:3457-67. 2004
    ..Thus, polaris and primary cilia function are required for the maturation and maintenance of proper tissue organization in the pancreas...
  87. pmc Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    Senta Georgia
    Department of Biochemistry and Molecular Biology, University of Southern California, Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    J Clin Invest 114:963-8. 2004
    ....
  88. ncbi Foxa2 is required for the differentiation of pancreatic alpha-cells
    Catherine S Lee
    Department of Genetics and Penn Diabetes Center, University of Pennsylvania School of Medicine, 415 Curie Boulevard, CRB 560 Philadelphia, PA 19104, USA
    Dev Biol 278:484-95. 2005
    ..detail; however, little is known about the factors that delineate the second-most abundant endocrine lineage, the glucagon-producing alpha-cell...
  89. ncbi Endodermal expression of Nkx6 genes depends differentially on Pdx1
    Jesper K Pedersen
    Department of Developmental Biology, Hagedorn Research Institute, Niels Steensensvej 6, DK 2820, Gentofte, Denmark
    Dev Biol 288:487-501. 2005
    ..2 or Nkx6.3 expression in anterior chicken endoderm. These results demonstrate that Nkx6.1 lies downstream of Pdx1 in a genetic pathway and that Pdx1 is required and sufficient for Nkx6.1 expression in the early foregut endoderm...
  90. pmc Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
    Claude Knauf
    UMR 5018, Universite Paul Sabatier, IFR31, Toulouse, France USA
    J Clin Invest 115:3554-63. 2005
    Intestinal glucagon-like peptide-1 (GLP-1) is a hormone released into the hepatoportal circulation that stimulates pancreatic insulin secretion...
  91. ncbi Generation and characterization of monoclonal antibodies against the transcription factor Nkx6.1
    Inger L Pedersen
    Antibody Core, Beta Cell Biology Consortium
    J Histochem Cytochem 54:567-74. 2006
    ..The presented antibodies are useful tools for the further characterization of the role and function of Nkx6.1 in pancreatic development, especially for use in double-labeling experiments with existing polyclonal rabbit antibodies...
  92. pmc Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus
    Nora G Smart
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 4:e39. 2006
    ..Thus, our studies reveal that TGF-beta signaling is crucial for establishing and maintaining defining features of mature pancreatic beta cells...
  93. pmc Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice
    Gamze Kilic
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Dev Dyn 235:1659-67. 2006
    ..Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses...
  94. pmc A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells
    Wataru Nishimura
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA 02215, USA
    Dev Biol 293:526-39. 2006
    ..Ectopically expressed large-Maf factors, MafA, MafB, or cMaf, induced expression from insulin and glucagon reporter constructs, demonstrating a redundancy in their function...
  95. ncbi FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells
    Caroline M McKinnon
    Henry Wellcome Laboratories for Integrated Cell Signalling and Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, United Kingdom
    J Biol Chem 281:39358-69. 2006
    ..FoxO1 silencing also abolished the acute regulation by insulin, but not glucose, of glucagon secretion, demonstrating the importance of FoxO1 expression in maintaining the alpha-cell phenotype.
  96. pmc SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
    ..These findings will be of major significance for the development of in vitro protocols for cell replacement therapies...
  97. pmc Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 117:961-70. 2007
    ..in adult mice, the misexpression of Arx, rather than its overexpression, promotes a conversion of beta cells into glucagon- or PP-producing cells in vivo...
  98. ncbi The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells
    Shelley B Nelson
    Department of Developmental and Cell Biology, University of California at Irvine, 4203 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 134:2491-500. 2007
    ..2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities and implies that both Nkx6.1 and Nkx6.2 possess alpha- and beta-cell-specifying activities...
  99. pmc Sox9 coordinates a transcriptional network in pancreatic progenitor cells
    F C Lynn
    Diabetes Center, Hormone Research Institute, and Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:10500-5. 2007
    ..These studies indicate that Sox9 plays a dual role in pancreatic progenitor cells: both maintaining a stable transcriptional network and supporting the programs by which these cells differentiate into distinct lineages...
  100. ncbi A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice
    Rhonda D Wideman
    Department of Cellular and Physiological Sciences, Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Diabetes 56:2744-52. 2007
    b>Glucagon, which raises blood glucose levels by stimulating hepatic glucose production, is produced in alpha-cells via cleavage of proglucagon by prohormone convertase (PC)-2...
  101. pmc Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
    Hyeung Jin Jang
    National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:15069-74. 2007
    b>Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown...

Research Grants9

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  2. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  3. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007
    ..abstract_text> ..
  4. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  6. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Foxm 1b endocrine pancreas growth and regeneration
    Maureen Gannon; Fiscal Year: 2009
    ..A thorough understanding of Foxml regulation of 3 cell mass may lead to strategies for maintaining 3 cell mass and enhancing 3 cell proliferation in diabetics. ..
  8. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
    ..Additionally, this information should allow us to coax embryonic stem cells into becoming important transplantable derivatives of endoderm, such as insulin-producing beta cells to treat patients with Type 1 diabetes. ..
  9. HNF6 Function in the Pancreatic Endocrine Lineage
    Maureen A Gannon; Fiscal Year: 2010
    ..e. is HNF6 needed only at early stages of endocrine specification, or is it required continuously during embryogenesis for terminal differentiation and acquisition of mature function. ..