Gata2

Summary

Gene Symbol: Gata2
Description: GATA binding protein 2
Alias: Gata-2, endothelial transcription factor GATA-2
Species: mouse

Top Publications

  1. ncbi Dynamic GATA factor interplay at a multicomponent regulatory region of the GATA-2 locus
    Melissa L Martowicz
    University of Wisconsin Medical School, Molecular and Cellular Pharmacology Program, Department of Pharmacology, Madison, Wisconsin 53706, USA
    J Biol Chem 280:1724-32. 2005
  2. ncbi GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene
    Y K Ng
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500
    Development 120:3257-66. 1994
  3. ncbi Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells
    M J Weiss
    Division of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1184-97. 1994
  4. ncbi An early haematopoietic defect in mice lacking the transcription factor GATA-2
    F Y Tsai
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 371:221-6. 1994
  5. ncbi Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation
    F Y Tsai
    Division of Hematology Oncology and Howard Hughes Medical Institute, Children s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Blood 89:3636-43. 1997
  6. ncbi Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac
    M C Yoder
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Immunity 7:335-44. 1997
  7. ncbi Alternative promoters regulate transcription of the mouse GATA-2 gene
    N Minegishi
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305, Japan
    J Biol Chem 273:3625-34. 1998
  8. ncbi Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system
    J Nardelli
    Cytosquelette et Développement, CNRS URA 2115, CHU Pitie Salpetriere, 105 Boulevard de l Hôpital, Paris Cedex, 75 634, France
    Dev Biol 210:305-21. 1999
  9. ncbi The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region
    N Minegishi
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    Blood 93:4196-207. 1999
  10. ncbi GATA3 is downregulated during hair cell differentiation in the mouse cochlea
    M N Rivolta
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    J Neurocytol 27:637-47. 1998

Research Grants

  1. FOG1 AND HEMATOPOIESIS
    Alan Cantor; Fiscal Year: 2003
  2. Proteomic Study of Megakaryocyte Transcriptional Control
    Alan Cantor; Fiscal Year: 2007
  3. Proteomic Approach to Further Understanding the Role of*
    Alan Cantor; Fiscal Year: 2008
  4. Gene Modifiers of Retinal Degeneration
    HENRY DANCIGER; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications136 found, 100 shown here

  1. ncbi Dynamic GATA factor interplay at a multicomponent regulatory region of the GATA-2 locus
    Melissa L Martowicz
    University of Wisconsin Medical School, Molecular and Cellular Pharmacology Program, Department of Pharmacology, Madison, Wisconsin 53706, USA
    J Biol Chem 280:1724-32. 2005
    ..We propose that GATA-2 transcription is regulated via the collective actions of complexes assembled at the -2.8- and -1.8-kb regions, which share similar properties, and through a qualitatively distinct activity of the -3.9-kb complex...
  2. ncbi GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene
    Y K Ng
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500
    Development 120:3257-66. 1994
    ....
  3. ncbi Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells
    M J Weiss
    Division of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1184-97. 1994
    ..The approach used here is a paradigm for the phenotypic analysis of targeted mutations affecting hematopoietic development...
  4. ncbi An early haematopoietic defect in mice lacking the transcription factor GATA-2
    F Y Tsai
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 371:221-6. 1994
    ..We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells...
  5. ncbi Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation
    F Y Tsai
    Division of Hematology Oncology and Howard Hughes Medical Institute, Children s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Blood 89:3636-43. 1997
    ..Analysis of GATA-2-/-/p53-/- compound-mutant embryos shows that the absence of p53 partially restores the number of total GATA-2-/- hematopoietic cells, and therefore suggests a potential link between GATA-2 and p53 pathways...
  6. ncbi Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac
    M C Yoder
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Immunity 7:335-44. 1997
    ..Surprisingly, 37-fold more CD34+c-Kit+ cells reside in the day 9 yolk sac than in the P-Sp. In sum, definitive HSC are coexistent, but not equal in number, in the murine yolk sac and P-Sp prior to fetal liver colonization...
  7. ncbi Alternative promoters regulate transcription of the mouse GATA-2 gene
    N Minegishi
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305, Japan
    J Biol Chem 273:3625-34. 1998
    ..These data indicate that the proximal 80 base pair region of IS promoter is important for the generation of cell type-specific expression of mGATA-2 from the IS exon...
  8. ncbi Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system
    J Nardelli
    Cytosquelette et Développement, CNRS URA 2115, CHU Pitie Salpetriere, 105 Boulevard de l Hôpital, Paris Cedex, 75 634, France
    Dev Biol 210:305-21. 1999
    ....
  9. ncbi The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region
    N Minegishi
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    Blood 93:4196-207. 1999
    ..These experiments describe an early developmental GATA-2 hematopoietic enhancer located between 6.0 and 2.5 kbp 5' to the IS exon...
  10. ncbi GATA3 is downregulated during hair cell differentiation in the mouse cochlea
    M N Rivolta
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    J Neurocytol 27:637-47. 1998
    ..We suggest that GATA3 could act as a repressor of critical genes involved in cell differentiation in the organ of Corti, enabling a progressive formation of the adult cellular pattern...
  11. ncbi The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4
    I Pata
    Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
    Development 126:5523-31. 1999
    ..Function of GATA3 in ventral rhombomere (r) 4 is dependent on functional GATA2, which in turn is under the control of Hoxb1...
  12. ncbi GATA factors are essential for transcription of the survival gene E4bp4 and the viability response of interleukin-3 in Ba/F3 hematopoietic cells
    Yung luen Yu
    Graduate Institute of Life Sciences, National Defense Medical Center, Academia Sinica, No 128, Sec 2, Yen Jiou Yuan Road, Taipei, 115 Taiwan
    J Biol Chem 277:27144-53. 2002
    ..Taken together, our results suggest that the GATA factors play an important role in transducing the survival signal of IL-3, and one of their cellular targets is E4bp4...
  13. pmc Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors
    Berthold Gottgens
    University of Cambridge Department of Haematology, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK
    EMBO J 21:3039-50. 2002
    ..Our results suggest that these transcription factors are key components of an enhanceosome responsible for activating SCL transcription and establishing the transcriptional programme required for HSC formation...
  14. pmc GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors
    Kenji Kitajima
    Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita 565 0871, Japan
    EMBO J 21:3060-9. 2002
    ....
  15. pmc GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis
    Aaron N Chang
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:9237-42. 2002
    ..On the basis of these and previous reports, we infer that GATA factor dependence is a critical aspect of FOG protein function...
  16. ncbi GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21(WAF1) and p27(Kip1) proteins
    Sachiko Ezoe
    Department of Hematology Oncology and Molecular Oncology, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita, Osaka, Japan
    Blood 100:3512-20. 2002
    ..These results suggest that GATA-2 may regulate expression levels of p21(WAF1) and p27(Kip1), thereby contributing to the quiescence of hematopoietic stem/progenitor cells...
  17. ncbi Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos
    Naoko Minegishi
    Institute of Basic Medical Sciences, Tsukuba, Japan
    Blood 102:896-905. 2003
    ..A reduction of GATA-2 expression or activity is required for the differentiation of precursors to hematopoietic cells...
  18. pmc GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    Jeffrey A Grass
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 383 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:8811-6. 2003
    ..Such a mechanism is predicted to be critical for the control of hematopoiesis...
  19. ncbi Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus
    M C Tiveron
    CNRS UMR 6156, NMDA IBDM, Case 907 Parc Scientifique de Luminy, 13288, Marseille Cedex 9, France
    Dev Biol 260:46-57. 2003
    ....
  20. ncbi Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development
    Yuko Fujiwara
    Children s Hospital, Enders 760, 300 Longwood Ave, Boston, MA 02115, USA
    Blood 103:583-5. 2004
    ..Thus, the function of GATA-1 and GATA-2 overlaps at the yolk sac stage. Moreover, a GATA factor, either GATA-1 or GATA-2, is required to initiate blood formation in the embryo...
  21. ncbi Gata2 specifies serotonergic neurons downstream of sonic hedgehog
    Sarah E Craven
    Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Development 131:1165-73. 2004
    ..2 and Nkx6.1 cooperate to induce the closely related zinc-finger transcription factors Gata2 and Gata3...
  22. pmc GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells
    Kam Wing Ling
    Department of Cell Biology and Genetics, Eramus University Medical Center, 3000 DR Rotterdam, Netherlands
    J Exp Med 200:871-82. 2004
    ..Thus, GATA-2 plays at least two functionally distinct roles during ontogeny of HSCs: the production and expansion of HSCs in the aorta-gonad-mesonephros and the proliferation of HSCs in the adult bone marrow...
  23. ncbi RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells
    Alex Robert-Moreno
    Centre Oncologia Molecular, IDIBELL Institut de Recerca Oncologica, Hospitalet, Barcelona 08907, Spain
    Development 132:1117-26. 2005
    ..progenitors, accompanied by the lack of expression of the hematopoietic transcription factors Aml1/Runx1, Gata2 and Scl/Tal1. We show that in wild-type embryos, a few cells lining the aorta endothelium at E9...
  24. ncbi Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis
    Neil P Rodrigues
    Center for Regenerative Medicine and Technology, Massachusetts General Hospital, Boston, MA 02129, USA
    Blood 106:477-84. 2005
    ..Thus, GATA-2 dose regulates adult stem-cell homeostasis by affecting select aspects of stem cell function...
  25. pmc GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene
    Maki Kobayashi-Osaki
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Japan
    Mol Cell Biol 25:7005-20. 2005
    ..The expression of a green fluorescent protein (GFP) reporter placed under the control of a 3.1-kbp Gata2 gene regulatory domain 5' to the distal first exon (IS) mirrored that of the endogenous Gata2 gene within the P-Sp ..
  26. ncbi Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2
    Kenji Kitajima
    Department of Pathology, Medical School and Graduate School of Frontier Biosciences, Osaka University, Yamada oka 2 2, Suita, Osaka 565 0871, Japan
    Blood 107:1857-63. 2006
    ..1 promoter region. This study demonstrates that the function of GATA-2 is modified in a context-dependent manner by expression of PU.1, which in turn is regulated by GATA-2...
  27. ncbi Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function
    Michael A Charles
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
    Mol Endocrinol 20:1366-77. 2006
    b>GATA2 is expressed in the pituitary during development and in adult gonadotropes and thyrotropes. It is proposed to be important for gonadotrope and thyrotrope cell fate choice and for TSH production...
  28. pmc Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE
    Gregory D Gregory
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3010, USA
    J Clin Invest 116:1327-36. 2006
    ..These events likely contribute to the genetically determined heterogeneity in Th1 responses that underlie susceptibility to many diseases...
  29. ncbi Context-dependent GATA factor function: combinatorial requirements for transcriptional control in hematopoietic and endothelial cells
    Ryan J Wozniak
    Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    J Biol Chem 282:14665-74. 2007
    ..For example, GATA-1 and GATA-2 occupy five conserved regions over approximately 100 kb of the Gata2 locus in the transcriptionally repressed and active states, respectively, in erythroid cells...
  30. ncbi Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis
    John Jacob
    Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Neurosci 10:1433-9. 2007
    ..Moreover, the subsequent differentiation of central serotonergic neurons required both the suppression of VMN neurogenesis and the induction of downstream intrinsic determinants of serotonergic identity by Foxa2...
  31. pmc Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development
    John E Pimanda
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 104:17692-7. 2007
    ..We describe a regulatory circuit made up of Gata2, Fli1, and Scl/Tal1 and their enhancers, Gata2-3, Fli1+12, and Scl+19, that operates during specification of ..
  32. doi GATA-2 regulates granulocyte-macrophage progenitor cell function
    Neil P Rodrigues
    Medical Research Council Hematology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Blood 112:4862-73. 2008
    ..These data collectively point to GATA-2 as a novel, pivotal determinant of GMP cell fate...
  33. pmc Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1-deficient serotonin neuron precursors
    Katherine C Krueger
    Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 28:12748-58. 2008
    ..Our findings identify a direct transcriptional interaction between Gata-2 and FEV and a unique marker for new insight into FEV/Pet-1 function in 5-HT neuron development...
  34. pmc A mechanosensitive transcriptional mechanism that controls angiogenesis
    Akiko Mammoto
    Vascular Biology Program, Department of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 457:1103-8. 2009
    ..the balance of activities between two antagonistic transcription factors, TFII-I (also known as GTF2I) and GATA2, that govern gene expression of the VEGF receptor VEGFR2 (also known as KDR)...
  35. pmc GATA-2 reinforces megakaryocyte development in the absence of GATA-1
    Zan Huang
    Division of Hematology and Oncology, Northwestern University, Lurie Research Building 5 113, Chicago, IL 60611, USA
    Mol Cell Biol 29:5168-80. 2009
    ..Moreover, our data reveal that overexpression of GATA-2 facilitates aberrant megakaryopoiesis...
  36. pmc A single cis element maintains repression of the key developmental regulator Gata2
    Jonathan W Snow
    Division of Hematology Oncology, Children s Hospital Boston, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1001103. 2010
    ..Here, we have analyzed cis element regulation of the critical hematopoietic factor Gata2, which is expressed in early precursors and repressed as GATA-1 levels rise during terminal differentiation...
  37. doi Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators
    Nicola K Wilson
    University of Cambridge Department of Haematology, Cambridge Institute for Medical Research, Hills Road, Cambridge, CB2 0XY, UK
    Cell Stem Cell 7:532-44. 2010
    ..and combinatorial interactions for ten key regulators of blood stem/progenitor cells (SCL/TAL1, LYL1, LMO2, GATA2, RUNX1, MEIS1, PU...
  38. pmc Context-dependent function of "GATA switch" sites in vivo
    Jonathan W Snow
    Division of Hematology Oncology, Children s Hospital Boston, Boston, MA, USA
    Blood 117:4769-72. 2011
    ..To address this problem in the context of the locus encoding the critical hematopoietic transcription factor Gata2, we engineered mice lacking a cluster of GATA motifs 2.8 kb upstream of the Gata2 transcriptional start site...
  39. pmc Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity
    Kirby D Johnson
    Department of Cell and Regenerative Biology, Wisconsin Institutes for Medical Research, UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    J Clin Invest 122:3692-704. 2012
    Haploinsufficiency for GATA2 causes human immunodeficiency syndromes characterized by mycobacterial infection, myelodysplasia, lymphedema, or aplastic anemia that progress to myeloid leukemia...
  40. pmc Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning
    Kim Chew Lim
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    J Clin Invest 122:3705-17. 2012
    ..regulatory properties of this enhancer, we generated a tamoxifen-inducible Cre transgenic mouse line using the Gata2 VE enhancer (Gata2 VECre) and utilized it to temporally direct tissue-specific conditional loss of Gata2...
  41. ncbi Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes
    Anthony Gavalas
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 130:5663-79. 2003
    ..Therefore, we have delineated the functional requirements in hindbrain neuronal patterning that follow the establishment of the genetic regulatory hierarchy between Hoxa1, Hoxb1 and Hoxb2...
  42. ncbi Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse
    I N Bespalova
    Department of Human Genetics and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Genomics 63:69-74. 2000
    ..Radiation hybrid mapping localized human LMCD1 to the telomeric region of chromosome 3p, and genetic mapping assigned the mouse Lmcd1 locus to the central region of chromosome 6...
  43. ncbi Hematopoietic transcription factor GATA-2 promotes upregulation of alpha globin and cell death in FL5.12 cells
    K Brecht
    Novartis Institutes for BioMedical Research Basel, CH 4002 Basel, Switzerland
    Apoptosis 10:1063-78. 2005
    ..We suggest a role of GATA-2 in apoptosis besides its function in maintenance and proliferation of immature hematopoietic progenitors...
  44. doi Lowered expressions of the NF-kappaB family members in dendritic cells from NOD mice are associated with a reduced expression of GATA-2
    Kazuma Takahashi
    Department of Diabetes and Metabolism, Iwate Medical University, Morioka, Japan
    Ann N Y Acad Sci 1150:59-60. 2008
    ..The reduction of NF-kappaB components possibly underlies the defective phenotype and function of DCs from NOD mice, and could predispose to autoimmunity...
  45. doi Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification
    Arnaud Gandillet
    Cancer Research UK, Stem Cell Haematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, United Kingdom
    Blood 114:4813-22. 2009
    ..Furthermore, our data demonstrate that the mere sustained expression of Sox7 is sufficient to completely alter the balance between proliferation and differentiation at the onset of hematopoiesis...
  46. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
    ..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription...
  47. pmc Regulation of GATA factor expression is distinct between erythroid and mast cell lineages
    Shin Ya Ohmori
    Department of Pharmacy, Takasaki University of Health and Welfare, Gunma, Japan
    Mol Cell Biol 32:4742-55. 2012
    The zinc finger transcription factors GATA1 and GATA2 participate in mast cell development...
  48. pmc Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels
    Davina Tondeleir
    Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    PLoS ONE 8:e67855. 2013
    ..Reduced levels of Gata2, were associated to this phenotype...
  49. pmc GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2
    Silvia Coma
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Karp Building, Room 12 210, 1 Blackfan Circle, Boston, MA, 02115, USA
    Angiogenesis 16:939-52. 2013
    GATA-binding protein 2 (GATA2) and LIM domain only 2 (Lmo2) form common transcription complexes during hematopoietic differentiation...
  50. pmc Mechanism governing a stem cell-generating cis-regulatory element
    Rajendran Sanalkumar
    Department of Cell and Regenerative Biology, Wisconsin Institutes for Medical Research, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705
    Proc Natl Acad Sci U S A 111:E1091-100. 2014
    ..Previously, we described five dispersed Gata2 locus sequences, termed the -77, -3.9, -2.8, -1.8, and +9...
  51. doi Low-level GATA2 overexpression promotes myeloid progenitor self-renewal and blocks lymphoid differentiation in mice
    Satish K Nandakumar
    Department of Experimental Hematology, St Jude Children s Research Hospital, Memphis, TN, USA Electronic address
    Exp Hematol 43:565-77.e1-10. 2015
    The transcription factor GATA2 is highly expressed in hematopoietic stem cells and is downregulated during lineage maturation...
  52. pmc Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2
    Paul A Dutchak
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Cell Rep 12:371-9. 2015
    ....
  53. pmc Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition
    Carlos O Lizama
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA
    Nat Commun 6:7739. 2015
    ..haematopoietic cells due to loss of Sox17-mediated repression of haematopoietic transcription factors (Runx1 and Gata2). However, the increase in EHT can be abrogated by increased Notch signalling...
  54. pmc Gata2 Is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice
    Xiaoxiao Li
    Department of Pharmacology X L, H H, H Z, Y W, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 and Department of Veterinary Biosciences M S, University of Helsinki, Helsinki 00014, Finland
    Endocrinology 157:1021-8. 2016
    b>Gata2 is a zinc finger transcription factor that is important in hematopoiesis and neuronal development. However, the roles of Gata2 in the mesenchymal lineages are poorly understood...
  55. doi Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells
    Yong Jin Choi
    Division of Cellular and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94705, USA
    Science . 2017
    ..MERVL expression through transcriptional regulation, at least in part, by targeting the transcription factor Gata2. Altogether, our studies reveal a complex molecular network that defines and restricts pluripotent developmental ..
  56. pmc UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice
    Keiko Ainoya
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Cell Biol 32:2312-22. 2012
    ..We found that anteriorly displaced budding led to obstructed megaureters in Gata2 hypomorphic mutant mice, possibly due to reduced expression of the downstream effector bone morphogenetic protein ..
  57. doi Mouse embryonic head as a site for hematopoietic stem cell development
    Zhuan Li
    307 Ivy Translational Medicine Center, Laboratory of Oncology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China
    Cell Stem Cell 11:663-75. 2012
    ..We conclude that the mouse embryonic head is a previously unappreciated site for HSC emergence within the developing embryo...
  58. pmc SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster
    Erin Eun Young Ahn
    Moores UCSD Cancer Center, The University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:5381-8. 2013
    ..Our data revealed a previously unidentified role of SON in microRNA production via regulating the transcription process, thereby modulating GATA-2 at the protein level during hematopoietic differentiation...
  59. doi Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    Katrin Kierdorf
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 16:273-80. 2013
    ..Our data provide cellular and molecular insights into the origin and development of microglia...
  60. doi Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages
    Simon R W Stott
    Developmental Neurobiology, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Neurosci 33:8022-34. 2013
    ..These results extend previous findings and demonstrate a later role for Foxa genes in regulating the maintenance of dopaminergic phenotype in mDA neurons...
  61. ncbi Gata2 maps to mouse chromosome 6
    S L Ciciotte
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mamm Genome 8:69-70. 1997
  62. ncbi GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo
    G T Ma
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208, USA
    Development 124:907-14. 1997
    ....
  63. ncbi The rat microphthalmia-associated transcription factor gene (Mitf) maps at 4q34-q41 and is mutated in the mib rats
    K Opdecamp
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 9:617-21. 1998
    ..transcription factor (Mitf) was assigned to rat Chromosome (Chr) 4q34-q41, as well as the Gata2 and Mem1 genes...
  64. ncbi Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types
    J S Dasen
    Howard Hughes Medical Institute, Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla 92093 0648, USA
    Cell 97:587-98. 1999
    ..ventral pituitary cell types is mediated via the reciprocal interactions of two transcription factors, Pit1 and GATA2, which are epistatic to the remainder of the cell type-specific transcription programs and serve as the molecular ..
  65. pmc A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis
    A M Barbieri
    Telethon Institute of Genetics and Medicine, San Raffaele Biomedical Science Park, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 96:10729-34. 1999
    ..Altogether, these data indicate that vax2 plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle...
  66. ncbi Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
    C R Lin
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Nature 401:279-82. 1999
    ..Thus, Pitx2 is a transcription factor that encodes 'leftness' of the lung...
  67. pmc Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
    C Kioussi
    Howard Hughes Medical Institute, University of California San Diego, School, Department of Medicine, 9500 Gilman Drive, Cellular and Molecular Medicine Room 345, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 96:14378-82. 1999
    ..We suggest that the transient dorsal expression of Pax6 is essential for establishing a sharp boundary between dorsal and ventral cell types, based on the inhibition of Shh ventral signals...
  68. ncbi Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors
    Susan E Crawford
    Department of Pathology, Northwestern University School of Medicine, Chicago, Illinois 60611 3008, USA
    J Biol Chem 277:3585-92. 2002
    ..These observations identify the GATA family of transcription factors as a new interacting partner of PBP and demonstrate that PBP is essential for normal development of vital organ systems...
  69. ncbi Sexually dimorphic expression of Gata-2 during mouse gonad development
    Pam Siggers
    MRC Mammalian Genetics Unit, Harwell, OX11 0RD, Didcot, UK
    Mech Dev 111:159-62. 2002
    ..Comparative in situ hybridisation using the germ cell marker Oct4 (EMBO J., 8, 2543) indicates that Gata-2 transcripts are restricted to the germ cell lineage at 13.5 dpc...
  70. ncbi Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification
    Hoonkyo Suh
    Neuroscience Program, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0638, USA
    Development 129:329-37. 2002
    ..Mechanistically, this is due to the dependence of several critical lineage-specific transcription factors, Pit1, Gata2, Egr1 and Sf1, on a threshold level of PITX2...
  71. pmc Charge movement and transcription regulation of L-type calcium channel alpha(1S) in skeletal muscle cells
    Zhenlin Zheng
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Physiol 540:397-409. 2002
    ..This study demonstrates that the transcription factors CREB, GATA-2 and SOX-5 play a significant role in the expression of the skeletal muscle DHPR or L-type Ca(2+) channel alpha(1S)...
  72. pmc Essential and instructive roles of GATA factors in eosinophil development
    Ryutaro Hirasawa
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Exp Med 195:1379-86. 2002
    ..Taken together, our findings establish essential and instructive roles of GATA factors in eosinophil development. GATA-1 and GATA-2 could be novel molecular targets for therapeutic approaches to allergic inflammation...
  73. ncbi Coexpression of SCL and GATA3 in the V2 interneurons of the developing mouse spinal cord
    Emma Smith
    Institute for Molecular Bioscience, incorporating the Special Research Centre for Functional and Applied Genomics, The University of Queensland, Brisbane, Australia
    Dev Dyn 224:231-7. 2002
    ..These experiments revealed that SCL is expressed in a medially restricted subpopulation of GATA-3 producing cells, suggesting a possible role for this factor in the differentiation of the GATA population of V2 interneurons...
  74. ncbi Domains of Pit-1 required for transcriptional synergy with GATA-2 on the TSH beta gene
    David F Gordon
    Department of Medicine, University of Colorado Health Sciences Center, Box B151, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Mol Cell Endocrinol 196:53-66. 2002
    ..Thus multiple domains of Pit-1 are required for full synergy with GATA-2 and sequences between the two binding sites contribute to co-occupancy with both factors on the proximal TSH beta promoter...
  75. ncbi Ascl1/Mash1 is required for the development of central serotonergic neurons
    Alexandre Pattyn
    CNRS UMR 8542, Ecole Normale Superieure, 75005 Paris, France
    Nat Neurosci 7:589-95. 2004
    ..Thus Ascl1, which is essential for noradrenergic differentiation, is also a determinant of the serotonergic phenotype...
  76. pmc Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2
    Eduardo Anguita
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    EMBO J 23:2841-52. 2004
    ....
  77. ncbi GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity
    Sachiko Ezoe
    Department of Hematology Oncology, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:13163-70. 2005
    ..Together, these results suggest that, besides the roles as transcription factors, GATA family proteins modulate cytokine signals through protein-protein interactions, thereby regulating the growth and survival of hematopoietic cells...
  78. ncbi Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis
    Rossella Menghini
    Department of Internal Medicine, University of Rome Tor Vergata, Policlinico Tor Vergata PTV University Hospital, Rome, Italy
    Circulation 111:1946-53. 2005
    Obesity-related inflammation is emerging as a major cause of insulin resistance and cardiovascular diseases. GATA2 transcription factor is an inhibitor of adipogenesis and an activator of vascular cells...
  79. ncbi Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets
    Zhiyv Niu
    Center for Cardiovascular Development, Division of Cardiovascular Sciences, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    J Biol Chem 280:32531-8. 2005
    ....
  80. pmc Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord
    Shengguo Li
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 102:10688-93. 2005
    ..However, coexpression of both Foxn4 and Mash1 promotes the V2b fate while inhibiting the V2a fate, indicating that Foxn4 cooperates with Mash1 to specify the identity of V2b neurons from bipotential p2 progenitors...
  81. pmc The transcription factor GATA2 regulates differentiation of brown adipocytes
    Judy Tsai
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    EMBO Rep 6:879-84. 2005
    ..We report here that GATA2 is expressed in brown adipocyte precursors, and its expression is downregulated in a differentiation-dependent ..
  82. ncbi MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropes
    David F Gordon
    Division of Endocrinology, Department of Medicine, University of Colorado Health Sciences Center Fitzsimons, Mail Stop 8106, P O Box 6511, Aurora, Colorado 80049, USA
    Mol Endocrinol 20:1073-89. 2006
    ..Thus, the TSHbeta gene is maximally activated by a combination of three thyrotrope transcription factors that act via both protein-DNA and protein-protein interactions...
  83. pmc Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche
    Norio Suzuki
    Japan Science and Technology Agency JST Exploratory Research for Advanced Technology ERATO Environmental Response Project, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Proc Natl Acad Sci U S A 103:2202-7. 2006
    ..In this study, we found that a Gata2 promoter directs activity in all HSCs...
  84. pmc Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system
    Yuka Morikawa
    Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, New Orleans, LA 70118, USA
    Dev Biol 307:114-26. 2007
    ..of other members of the transcriptional circuit regulating SNS development, including Phox2a/b, Mash1 and Gata2/3; however, Hand2 was required for Hand1 expression...
  85. doi CREB-binding proteins (CBP) as a transcriptional coactivator of GATA-2
    HuiJie Jiang
    College of Life Sciences, Ludong University, Yantai, 264025, China
    Sci China C Life Sci 51:191-8. 2008
    ....
  86. pmc Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage
    Alan B Cantor
    Division of Pediatric Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
    J Exp Med 205:611-24. 2008
    ..They also provide evidence for lineage instability during early stages of hematopoietic lineage commitment...
  87. doi Loss of the protein NUPR1 (p8) leads to delayed LHB expression, delayed ovarian maturation, and testicular development of a sertoli-cell-only syndrome-like phenotype in mice
    Christina M Million Passe
    Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
    Biol Reprod 79:598-607. 2008
    ..Factors indicative of pituitary maturation, GATA2, CGA, and TSH, are not differentially expressed in Nupr1(-/-) and Nupr1(+/+) embryos at e17.5...
  88. pmc Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis
    Lauren C Goldie
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Blood 112:3194-204. 2008
    ..Thus, we identify a novel, critical role for RA signaling in the development of hemogenic endothelium that contributes to definitive hematopoiesis...
  89. pmc Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses
    Mitsuaki Fujimoto
    Department of Biochemistry, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube 755 8505, Japan
    J Biol Chem 283:29961-70. 2008
    ..These results suggest novel mechanisms of gene regulation controlled by HSF4 in non-classic heat shock response and in lens development...
  90. pmc Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code
    John E Pimanda
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    Blood 112:4512-22. 2008
    ..By contrast Pu.1, an Ets factor specific to the blood lineage, and Gata2 binding was only detected in blood...
  91. pmc Context-dependent function of regulatory elements and a switch in chromatin occupancy between GATA3 and GATA2 regulate Gata2 transcription during trophoblast differentiation
    Soma Ray
    Institute of Maternal Fetal Biology and the Division of Cancer and Developmental Biology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 284:4978-88. 2009
    GATA transcription factors are important regulators of tissue-specific gene expression during development. GATA2 and GATA3 have been implicated in the regulation of trophoblast-specific genes...
  92. pmc LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons
    Kaumudi Joshi
    Department of Molecular Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 61:839-51. 2009
    ..We further demonstrate that LMO4 nucleates the assembly of a novel LIM-complex containing SCL, Gata2, and NLI...
  93. pmc Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants
    Zhenyun Yang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Cell Biol 29:4376-93. 2009
    ..Evaluation of hematopoietic-specific transcription factor expression indicates reduced GATA2 and elevated c-Jun in mutant Shp2-expressing progenitors...
  94. pmc Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity
    Mi Ryoung Song
    Bioimaging Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    Development 136:2923-32. 2009
    ....
  95. doi Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space
    Maarja Haugas
    Department of Veterinary Biosciences, University of Helsinki, Finland
    Dev Dyn 239:2452-69. 2010
    b>Gata2 has essential roles in the development of many organs...
  96. pmc VE-statin/egfl7 expression in endothelial cells is regulated by a distal enhancer and a proximal promoter under the direct control of Erg and GATA-2
    Alexandra Le Bras
    CNRS, Institut de Biologie de Lille, UMR 8161, Equipe Labellisée La Ligue, Lille, France
    PLoS ONE 5:e12156. 2010
    ....
  97. pmc Notch1-mediated signaling induces MHC class II expression through activation of class II transactivator promoter III in mast cells
    Nobuhiro Nakano
    Atopy Allergy Research Center, Department of Immunology, Juntendo Univesity School of Medicine, Tokyo, Japan
    J Biol Chem 286:12042-8. 2011
    ..These findings indicate that activation of CIITA pIII plays an important role in MHC class II expression in mast cells...
  98. pmc Murine leukemia retrovirus integration induces the formation of transcription factor complexes on palindromic sequences in the signal transducer and activator of transcription factor 5a gene during the development of pre-B lymphomagenesis
    Tatsuaki Tsuruyama
    Department of Forensic Medicine and Molecular Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Am J Pathol 178:1374-86. 2011
    ....
  99. pmc Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS
    Hui Wang
    Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Development 138:3711-21. 2011
    ..Together, our data reveal a Shh-Gli-independent transcriptional input that is required to shape the precise spatial and temporal response to extracellular morphogen signaling information during lineage segregation in the CNS...
  100. pmc Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene
    L Robb
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 92:7075-9. 1995
    ..Transcripts of GATA-1 and PU.1 transcription factors were absent from RNA from scl-/- yolk sacs and embryos. These results implicate scl as a crucial regulator of early hematopoiesis...

Research Grants4

  1. FOG1 AND HEMATOPOIESIS
    Alan Cantor; Fiscal Year: 2003
    ..abstract_text> ..
  2. Proteomic Study of Megakaryocyte Transcriptional Control
    Alan Cantor; Fiscal Year: 2007
    ..The results of this study should provide new insights into the transcriptional regulation of megakaryopoiesis, and possibly new therapeutic targets for disorders of megakaryocyte proliferation and development. ..
  3. Proteomic Approach to Further Understanding the Role of*
    Alan Cantor; Fiscal Year: 2008
    ..These studies should provide important insights that will facilitate the design of novel therapies for MDS. ..
  4. Gene Modifiers of Retinal Degeneration
    HENRY DANCIGER; Fiscal Year: 2009
    ..This would make therapeutic approaches simpler. ..