Gata1

Summary

Gene Symbol: Gata1
Description: GATA binding protein 1
Alias: Gata-1, Gf-1, eryf1, erythroid transcription factor, GATA-binding factor 1, NF-E1 DNA-binding protein
Species: mouse

Top Publications

  1. ncbi Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells
    M C Simon
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nat Genet 1:92-8. 1992
  2. ncbi A critical role for eosinophils in allergic airways remodeling
    Alison A Humbles
    Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 305:1776-9. 2004
  3. pmc ARR19 (androgen receptor corepressor of 19 kDa), an antisteroidogenic factor, is regulated by GATA-1 in testicular Leydig cells
    Imteyaz Qamar
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 284:18021-32. 2009
  4. ncbi Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2
    Melissa A Kacena
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06520 8071, USA
    J Bone Miner Res 19:652-60. 2004
  5. pmc PU.1 directly regulates cdk6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells
    Kevin S Choe
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 285:3044-52. 2010
  6. pmc Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development
    Andrew J Woo
    Department of Pediatric Oncology, Children s Hospital Boston Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 28:2675-89. 2008
  7. pmc Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage
    Alan B Cantor
    Division of Pediatric Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
    J Exp Med 205:611-24. 2008
  8. doi Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages
    Yojiro Arinobu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell Stem Cell 1:416-27. 2007
  9. ncbi FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
    A P Tsang
    Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:109-19. 1997
  10. ncbi Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation
    Kouichi Watamoto
    Department of Molecular Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466 8550, Japan
    Oncogene 22:9176-84. 2003

Research Grants

Scientific Experts

Detail Information

Publications149 found, 100 shown here

  1. ncbi Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells
    M C Simon
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nat Genet 1:92-8. 1992
    ..Use of in vitro differentiated ES cells bridges a gap between conventional approaches to gene function in cell lines and analysis of loss of function mutations in the whole animal...
  2. ncbi A critical role for eosinophils in allergic airways remodeling
    Alison A Humbles
    Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 305:1776-9. 2004
    ..These data suggest that eosinophils contribute substantially to airway remodeling but are not obligatory for allergen-induced lung dysfunction, and support an important role for eosinophil-targeted therapies in chronic asthma...
  3. pmc ARR19 (androgen receptor corepressor of 19 kDa), an antisteroidogenic factor, is regulated by GATA-1 in testicular Leydig cells
    Imteyaz Qamar
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 284:18021-32. 2009
    ....
  4. ncbi Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2
    Melissa A Kacena
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06520 8071, USA
    J Bone Miner Res 19:652-60. 2004
    ..Osteoblast proliferation increased up to 6-fold when cultured with megakaryocytes. A megakaryocyte-osteoblast interaction plays a role in the increased bone formation in these mice...
  5. pmc PU.1 directly regulates cdk6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells
    Kevin S Choe
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 285:3044-52. 2010
    ....
  6. pmc Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development
    Andrew J Woo
    Department of Pediatric Oncology, Children s Hospital Boston Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 28:2675-89. 2008
    ....
  7. pmc Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage
    Alan B Cantor
    Division of Pediatric Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
    J Exp Med 205:611-24. 2008
    ..They also provide evidence for lineage instability during early stages of hematopoietic lineage commitment...
  8. doi Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages
    Yojiro Arinobu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell Stem Cell 1:416-27. 2007
    ..1 primarily organizes the hematopoietic lineage fate decision to form the earliest hematopoietic branchpoint that comprises isolatable myeloerythroid and myelolymphoid progenitor populations...
  9. ncbi FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
    A P Tsang
    Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:109-19. 1997
    ..These findings indicate that FOG acts as a cofactor for GATA-1 and provide a paradigm for the regulation of cell type-specific gene expression by GATA transcription factors...
  10. ncbi Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation
    Kouichi Watamoto
    Department of Molecular Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466 8550, Japan
    Oncogene 22:9176-84. 2003
    ..These observations support the suggestion that control of the HDAC5 nucleocytoplasmic distribution might be associated with MEL cell differentiation, possibly through regulated GATA-1 transactivation...
  11. ncbi Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation
    Daijiro Sugiyama
    Department of Stem Cell Pathology, Medical School, Osaka University, Osaka, Japan
    Blood 111:1924-32. 2008
    ..These results indicate that FOG-1 inhibits mast-cell differentiation in a differentiation stage-dependent manner, and its effects are produced via different molecular mechanisms...
  12. ncbi Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis
    Ilkka Ketola
    Children s Hospital and Program for Developmental and Reproductive Biology, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland
    Eur J Endocrinol 147:397-406. 2002
    ..Therefore, we analyzed GATA-1, GATA-4, FOG-1 and FOG-2 expression in detail, from undifferentiated male urogenital ridge to adult testis...
  13. pmc Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression
    Timothy M Chlon
    Northwestern University, Division of Hematology Oncology, Chicago, IL 60611, USA
    Mol Cell 47:608-21. 2012
    ..We identified GATA1-selective and GATA-1(V205G)-selective binding sites and show that GATA-1, in the absence of FOG-1, occupies GATA-1(..
  14. ncbi Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels
    Norio Suzuki
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Blood 102:3575-83. 2003
    ..This study also presents an efficient method for enriching the CFU-E and BFU-E from mouse hematopoietic tissues...
  15. pmc Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    BMC Immunol 6:7. 2005
    ..It is therefore important to elucidate the molecular mechanisms regulating receptor expression...
  16. pmc GATA-2 reinforces megakaryocyte development in the absence of GATA-1
    Zan Huang
    Division of Hematology and Oncology, Northwestern University, Lurie Research Building 5 113, Chicago, IL 60611, USA
    Mol Cell Biol 29:5168-80. 2009
    ..leukemia in children with Down syndrome, a malignancy that is defined by the combination of trisomy 21 and a GATA1 mutation...
  17. pmc Differential coregulator requirements for function of the hematopoietic transcription factor GATA-1 at endogenous loci
    Nathaniel J Pope
    University of Wisconsin School of Medicine and Public Health, Wisconsin Institute for Medical Research, Madison, WI 53705, USA
    Nucleic Acids Res 38:2190-200. 2010
    ..These results illustrate both similarities and differences between GATA-1-mediated recruitment of FOG-1 and Med1 to chromatin, with a fundamental difference being the quantitatively greater requirement for FOG-1...
  18. ncbi T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice
    Li Ren Liu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    J Biol Chem 280:7452-9. 2005
    ..Both the -173 and -175 T to C substitutions may disrupt the complex assembly and result in the reactivation of the gamma-globin gene in adult erythrocytes...
  19. ncbi Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo
    Masatsugu Ema
    Department of Anatomy and Embryology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Blood 108:4018-24. 2006
    ..In contrast, GATA1, a marker for primitive erythropoietic progenitors, is expressed in a more restricted subset of Flk1-positive ..
  20. pmc A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction
    C D Trainor
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Mol Cell Biol 16:2238-47. 1996
    ..We propose that GATApal is important for positive regulation of GATA-1 expression in erythroid cells...
  21. pmc A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1
    M A McDevitt
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:6781-5. 1997
    ..Our work illustrates the usefulness of targeted mutations to create knockdown mutations that may uncover important quantitative contributions of gene function not revealed by conventional knockouts...
  22. ncbi Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation
    Y Yamaguchi
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    Blood 91:450-7. 1998
    ..These findings suggest that the upregulation of c-mpl induced by GATA-1 expression in M1 cells is closely associated with erythroid and megakaryocytic differentiation...
  23. ncbi Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com
    J M Derry
    Immunex Corporation, Seattle, Washington 98101 2936, USA
    Nat Genet 22:286-90. 1999
    ....
  24. pmc GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis
    Aaron N Chang
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:9237-42. 2002
    ..On the basis of these and previous reports, we infer that GATA factor dependence is a critical aspect of FOG protein function...
  25. pmc Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1
    H Osada
    Laboratory of Molecular Biology, Medical Research Council, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 92:9585-9. 1995
    ..Direct interaction of the RBTN2 protein was observed in vivo and in vitro with the GATA1 or -2 zinc-finger transcription factors, as well as with the basic helix-loop-helix protein TAL1...
  26. pmc Dissecting molecular steps in chromatin domain activation during hematopoietic differentiation
    Shin Il Kim
    University of Wisconsin School of Medicine, Department of Pharmacology, 383 Medical Sciences Center, Madison, WI 53706, USA
    Mol Cell Biol 27:4551-65. 2007
    ..These studies defined a hierarchical order of GATA-1-triggered events at a complex locus and establish a novel mechanism of long-range gene regulation...
  27. ncbi Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1
    D I Martin
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Genes Dev 4:1886-98. 1990
    ..The complex activation and DNA-binding properties of GF-1 are likely to contribute to the ability of this single protein to participate widely in gene expression throughout erythroid development...
  28. ncbi Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells
    K Yomogida
    Department of Biochemistry, Tohoku University School of Medicine, Japan
    Development 120:1759-66. 1994
    ..These observations suggest that transcription factor GATA-1 is a developmental stage- and spermatogenic cycle-specific regulator of gene expression in Sertoli cells...
  29. ncbi Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis
    E Ito
    Department of Pediatrics, Hirosaki University School of Medicine, Japan
    Nature 362:466-8. 1993
    ..The GATA-1-expressing cells in 10-week-old testis were found only in contact with the basement membrane of seminiferous tubules, suggesting that GATA-1 regulates genes during the earliest stages of spermatogenesis...
  30. pmc Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
    Y Fujiwara
    Children s Hospital, Department of Pediatrics, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 93:12355-8. 1996
    ..Moreover, the recovery of GATA-1+/- mice from anemia seen at birth provides evidence indicating a role for GATA-1 at the hematopoietic progenitor cell level...
  31. pmc A GATA box in the GATA-1 gene hematopoietic enhancer is a critical element in the network of GATA factors and sites that regulate this gene
    S Nishimura
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305 8577, Japan
    Mol Cell Biol 20:713-23. 2000
    ..Importantly, G1HE was active in SCL(-/-) embryos. These results thus demonstrate the presence of a critical network of GATA factors and GATA binding sites that controls the expression of this gene...
  32. ncbi Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors
    Susan E Crawford
    Department of Pathology, Northwestern University School of Medicine, Chicago, Illinois 60611 3008, USA
    J Biol Chem 277:3585-92. 2002
    ..These observations identify the GATA family of transcription factors as a new interacting partner of PBP and demonstrate that PBP is essential for normal development of vital organ systems...
  33. ncbi A minigene containing four discrete cis elements recapitulates GATA-1 gene expression in vivo
    Kinuko Ohneda
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Japan
    Genes Cells 7:1243-54. 2002
    ..However, G1HE is not sufficient to confer tissue specificity on the GATA-1 gene in vivo, indicating that additional regulatory sequences are necessary...
  34. ncbi Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter
    Keiko Maeda
    Atopy Allergy Research Center, Juntendo University School of Medicine, University of Tokyo, Japan
    J Immunol 170:334-40. 2003
    ..These results indicate that cell type-specific transcription of mouse beta-chain gene is regulated by GATA-1...
  35. ncbi Involvement of mitogen-activated protein kinase in the cytokine-regulated phosphorylation of transcription factor GATA-1
    Masayuki Towatari
    The Institute of Cancer Research, 237 Fulham Road, London B, UK
    Hematol J 5:262-72. 2004
    ..These data implicate receptor-mediated signalling through the MAPK pathway as a control point in the regulation of transcription factor GATA-1...
  36. ncbi The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells
    Akio Masuda
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Immunol 173:5564-73. 2004
    ..The results of the present study have shown that direct interaction between AP-1 and GATA proteins plays an important role in IL-13 transcription in mast cells...
  37. ncbi Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1
    Zhe Li
    Division of Hematology Oncology, Childrens Hospital, Boston, Massachusetts 02115, USA
    Nat Genet 37:613-9. 2005
    Acquired mutations in the hematopoietic transcription factor GATA binding protein-1 (GATA1) are found in megakaryoblasts from nearly all individuals with Down syndrome with transient myeloproliferative disorder (TMD, also called ..
  38. pmc Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation
    Veerendra Munugalavadla
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Cancer Research Institute, 1044 W Walnut Street, Room 425, Indianapolis, IN 46202, USA
    Mol Cell Biol 25:6747-59. 2005
    ..Our findings reveal a novel aspect of molecular cross talk between essential transcriptional and cytokine signaling components of hematopoietic development...
  39. pmc Multipotential differentiation ability of GATA-1-null erythroid-committed cells
    Kenji Kitajima
    Department of Pathology, Medical School and Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Dev 20:654-9. 2006
    ..Our data suggest that GATA-1 is a critical transcription factor to fix erythroid progenitors to the erythroid lineage...
  40. pmc Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
    David Voehringer
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:1435-46. 2006
    ..Thus, components of type 2 immunity mediated by IL-4/IL-13 are partitioned between T cell-dependent IgE and an innate non-eosinophil tissue component, suggesting new strategies for interventions in allergic immunity...
  41. ncbi Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1
    Chu Wai Liew
    School of Molecular and Microbial Biosciences, G08, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 281:28296-306. 2006
    ..1 interaction, resolving several issues in the existing data and providing insight into the mechanisms through which these two proteins combine to regulate blood development...
  42. pmc A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 103:16418-23. 2006
    ..In summary, we present multiple lines of independent evidence that eosinophils via CCR3 have a central role in chronic allergic airway disease...
  43. pmc Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo
    Tomomasa Yokomizo
    Institute of Basic Medical Sciences and Center for TARA, University of Tsukuba, Tsukuba, Japan
    EMBO J 26:184-96. 2007
    ..These results provide evidence of the presence of GATA-1(+) hemangioblastic cells in the extra-embryonic region and also their functional contribution to hematopoiesis in the embryo...
  44. pmc Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function
    Kirby D Johnson
    Department of Pharmacology, University of Wisconsin School of Medicine, Madison, WI, USA
    Blood 109:5230-3. 2007
    ..The identification of genes repressed by GATA-1 independent of FOG-1 defines a novel mode of GATA-1-mediated transcriptional regulation...
  45. pmc Non-random subcellular distribution of variant EKLF in erythroid cells
    Karen J Quadrini
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Cell Res 314:1595-604. 2008
    ..These studies suggest there is an unexplored role for EKLF in the cytoplasm that is separate from its well-characterized nuclear function...
  46. pmc SCL and associated proteins distinguish active from repressive GATA transcription factor complexes
    Tamara Tripic
    Division of Hematology, The Children s Hospital of Philadelphia, PA 19104, USA
    Blood 113:2191-201. 2009
    ..Together, these studies identify the SCL complex as a critical and consistent determinant of positive GATA-1 activity in multiple GATA-1-regulated hematopoietic cell lineages...
  47. pmc Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate
    Stella T Chou
    Division of Hematology, The Children s Hospital of Philadelphia, PA, USA
    Blood 114:983-94. 2009
    ..We used immortalized Gata1(-) erythromegakaryocytic progenitor cells to study how PU...
  48. ncbi Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells
    S F Tsai
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 339:446-51. 1989
    ..The factor, a new member of the zinc-finger family of DNA-binding proteins, is restricted to erythroid cells at the level of RNA expression and is closely homologous between mouse and man...
  49. ncbi Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells
    M J Weiss
    Division of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1184-97. 1994
    ..The approach used here is a paradigm for the phenotypic analysis of targeted mutations affecting hematopoietic development...
  50. pmc Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG
    A P Tsang
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 12:1176-88. 1998
    ..We speculate that FOG and other FOG-like proteins serve as complex cofactors that act through both GATA-dependent and GATA-independent mechanisms...
  51. ncbi hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation
    M Holmes
    Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales, Sydney, New South Wales 2052, Australia
    J Biol Chem 274:23491-8. 1999
    ..Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser...
  52. pmc GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    Jeffrey A Grass
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 383 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:8811-6. 2003
    ..Such a mechanism is predicted to be critical for the control of hematopoiesis...
  53. ncbi Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development
    Yuko Fujiwara
    Children s Hospital, Enders 760, 300 Longwood Ave, Boston, MA 02115, USA
    Blood 103:583-5. 2004
    ..Thus, the function of GATA-1 and GATA-2 overlaps at the yolk sac stage. Moreover, a GATA factor, either GATA-1 or GATA-2, is required to initiate blood formation in the embryo...
  54. pmc Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1
    David L Stachura
    Cell and Molecular Biology Graduate Program, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Blood 107:87-97. 2006
    ..To investigate these functions further, we stimulated Gata1- murine embryonic stem-cell-derived hematopoietic cultures with thrombopoietin, a multistage cytokine...
  55. pmc A GATA-1-regulated microRNA locus essential for erythropoiesis
    Louis C Dore
    Division of Hematology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:3333-8. 2008
    ..These results reveal a miRNA locus that is required for erythropoiesis and uncover a new regulatory axis through which GATA-1 controls this process...
  56. pmc Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes
    Annarita Miccio
    Division of Hematology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 30:3460-70. 2010
    ..These results suggest that, unexpectedly, NuRD is required for FOG-1-dependent activation of adult-type globin gene expression but is dispensable for human gamma-globin silencing in vivo...
  57. pmc Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis
    Jan Henning Klusmann
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
    Genes Dev 24:1659-72. 2010
    ..in Down syndrome acute megakaryoblastic leukemia (DS-AMKL), characterized by the triad of fetal origin, mutated GATA1 (GATA1s), and trisomy 21...
  58. pmc A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation
    Sandeep N Wontakal
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 109:3832-7. 2012
    ....
  59. pmc Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis
    Louis C Dore
    Division of Hematology Oncology, Northwestern University, Chicago, IL, USA
    Blood 119:3724-33. 2012
    ..We also reveal that the GATA switch, which entails a chromatin occupancy exchange between GATA2 and GATA1 in the course of differentiation, operates on more than one-third of GATA1 bound genes...
  60. ncbi Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
    L Pevny
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Nature 349:257-60. 1991
    ..This demonstrates that GATA-1 is required for the normal differentiation of erythroid cells, and that other GATA-binding proteins cannot compensate for its absence...
  61. pmc Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis
    M J Weiss
    Children s Hospital, Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 92:9623-7. 1995
    ..These results illustrate the multifunctional nature of GATA-1 and suggest a mechanism by which other hematopoietic transcription factors may ensure the development of specific lineages...
  62. ncbi Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:62-6. 1995
    ..These results indicate that Flk-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo...
  63. ncbi Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF
    A C Perkins
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts, USA
    Nature 375:318-22. 1995
    ..Its stage-specific and beta-globin-gene-specific requirement suggests that EKLF may facilitate completion of the fetal-to-adult (haemoglobin gamma to beta) switch in humans...
  64. ncbi Development of hematopoietic cells lacking transcription factor GATA-1
    L Pevny
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Development 121:163-72. 1995
    ....
  65. ncbi Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene
    S Takahashi
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tennodai, Tsukuba 305, Japan
    J Biol Chem 272:12611-5. 1997
    ....
  66. pmc A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development
    R A Shivdasani
    Department of Medicine, Dana Farber Cancer Institute, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 16:3965-73. 1997
    ..These findings reveal a critical role for GATA-1 in megakaryocyte growth regulation and platelet biogenesis, and illustrate how targeted mutation of cis-elements can generate lineage-specific knockout mice...
  67. ncbi Differential roles of GATA-1 and GATA-2 in growth and differentiation of mast cells
    H Harigae
    Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan
    Genes Cells 3:39-50. 1998
    ..To address this question, the expression of GATA-1 and GATA-2 mRNAs and proteins were examined in three mouse mast cell progenitor lines as well as in mast cells isolated from both wild-type and GATA-1-deficient mice...
  68. ncbi Consequences of GATA-1 deficiency in megakaryocytes and platelets
    P Vyas
    Department of Hematology Oncology and Howard Hughes Medical Institute, Children s Hospital, Boston, MA, USA
    Blood 93:2867-75. 1999
    ..Our findings indicate that GATA-1 serves multiple functions in megakaryocyte development, influencing both cellular growth and maturation...
  69. ncbi Increased expression of the distal, but not of the proximal, Gata1 transcripts during differentiation of primary erythroid cells
    A M Vannucchi
    Division of Hematology, University of Florence and Azienda Ospedale Careggi, Italy
    J Cell Physiol 180:390-401. 1999
    b>Gata1 is expressed from either one of two alternative promoters, the erythroid (proximal to the AUG) and the testis (distal to the AUG) promoter, both used by hemopoietic cells...
  70. ncbi Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
    J Palis
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, Box 777, Rochester, NY 14642, USA rochester edu
    Development 126:5073-84. 1999
    ....
  71. pmc Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation
    C S Raymond
    Graduate Program in Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genes Dev 14:2587-95. 2000
    ..As in the case of 9p deletions, Dmrt1 is dispensable for ovary development in the mouse. Thus, as in invertebrates, a DM domain gene regulates vertebrate male development...
  72. ncbi Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins
    H Motohashi
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences University of Tsukuba 1 1 1 Tennoudai 305 8577, Tsukuba, Japan
    Cell 103:865-75. 2000
    ..These results provide direct in vivo evidence that transcriptional regulation through MARE elements hinges on an exquisitely sensitive balance of activating CNC molecules and their small Maf partners...
  73. ncbi Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression (GATA-1(low) mice)
    A M Vannucchi
    Department of Hematology and Istituto di Oncologia and Patologia Sperimentali, Istituto di Anatomia Patologica, University of Florence, Italy
    Blood 97:3040-50. 2001
    ..In conclusion, the GATA-1(low) mutation increases the magnitude of the response to erythroid stimuli as a consequence of the expansion of the erythroid progenitor cells in their spleen...
  74. pmc In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis
    R Shimizu
    Institute of Basic Medical Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305 8577, Japan
    EMBO J 20:5250-60. 2001
    ....
  75. pmc Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo
    Channing Yu
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Exp Med 195:1387-95. 2002
    ..Mice lacking the ability to produce eosinophils should prove useful in ascertaining the role of eosinophils in a variety of inflammatory or allergic disorders...
  76. ncbi Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1(low) mice)
    Alessandro Maria Vannucchi
    Department of Ematologia, University of Florence, Italy
    Blood 100:1123-32. 2002
    ..In conclusion, impaired GATA-1 expression may contribute to the development of myelofibrosis, and the GATA-1(low) mutants may represent a suitable animal model for the human disease that may shed light on its pathogenesis...
  77. pmc Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1
    Danielle L Letting
    Division of Hematology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:1334-40. 2003
    ..Together, these results suggest that GATA-1 and its cofactor CBP are essential for the formation of an erythroid-specific acetylation pattern that is permissive for high levels of gene expression...
  78. pmc GATA-1-mediated proliferation arrest during erythroid maturation
    Marcin Rylski
    Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:5031-42. 2003
    ..Our results illustrate how GATA-1, a lineage-determining transcription factor, coordinates proliferation arrest with cellular maturation through distinct, interrelated genetic programs...
  79. pmc A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse
    Fokke Lindeboom
    Erasmus MC, Department of Cell Biology, Rotterdam, The Netherlands
    Nucleic Acids Res 31:5405-12. 2003
    The transcription factor Gata1 is essential for the development of erythroid cells. Consequently, Gata1 null mutants die in utero due to severe anaemia...
  80. pmc Modification of the erythroid transcription factor GATA-1 by SUMO-1
    Licio Collavin
    Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    Proc Natl Acad Sci U S A 101:8870-5. 2004
    ..Here, we demonstrate that the erythroid transcription factor GATA-1 is sumoylated in vitro and in vivo and map the single lysine residue involved in SUMO-1 ..
  81. pmc Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2
    Eduardo Anguita
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    EMBO J 23:2841-52. 2004
    ....
  82. ncbi Global regulation of erythroid gene expression by transcription factor GATA-1
    John J Welch
    The Children s Hospital of Philadelphia, Division of Hematology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 104:3136-47. 2004
    ..These findings define a regulatory loop for beta globin expression and, more generally, demonstrate how transcriptome analysis can be used to generate testable hypotheses regarding transcriptional networks...
  83. pmc GATA1 function, a paradigm for transcription factors in hematopoiesis
    Rita Ferreira
    Department of Cell Biology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 25:1215-27. 2005
  84. ncbi Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1
    Christopher R Vakoc
    Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Mol Cell 17:453-62. 2005
    ..Together, these data demonstrate that GATA-1 and FOG-1 are essential anchors for a tissue-specific chromatin loop, providing general insights into long-range enhancer function...
  85. pmc Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development
    Andrew G Muntean
    Ben May Institute for Cancer Research, Univeristy of Chicago, IL, USA
    Blood 106:1223-31. 2005
    b>GATA1 is mutated in patients with 2 different disorders...
  86. ncbi GATA-1 is required for expression of Fc{epsilon}RI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow
    Chiharu Nishiyama
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int Immunol 17:847-56. 2005
    ..We concluded that the transcription factor GATA-1 positively regulates FcepsilonRI alpha- and beta-chain expression and therefore is involved in mast cell development...
  87. pmc MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival
    Yung luen Yu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    J Biol Chem 280:29533-42. 2005
    ..Therefore, GATA-1 may represent a novel MAPK substrate that plays an essential role in a cytokine-mediated antiapoptotic response...
  88. pmc Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation
    Zahra Kadri
    Department of d Hématologie, Institute Cochin, INSERM U56, CNRS UMR 8104, Université René Descartes Hospital Cochin, Paris, France
    Mol Cell Biol 25:7412-22. 2005
    ..These findings provide the first example of a chain of coupling mechanisms between the binding of erythropoietin to its receptor and GATA-1-dependent gene expression...
  89. pmc Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo
    Heather M Rooke
    Division of Hematology Oncology, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Blood 107:3527-30. 2006
    ..The indispensable zinc-finger transcription factor, Gata1, is phosphorylated constitutively at 6 serine residues (26, 49, 72, 142, 178, 187), and at a seventh (310) ..
  90. pmc Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE
    Gregory D Gregory
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3010, USA
    J Clin Invest 116:1327-36. 2006
    ..b>GATA1/2 and Ikaros, factors with opposing roles in chromatin remodeling, acted at these sites...
  91. pmc Schistosoma mansoni infection in eosinophil lineage-ablated mice
    Jonathan M Swartz
    Laboratory of Allergic Diseases, NIAID, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1883, USA
    Blood 108:2420-7. 2006
    ..However, eosinophils may have unexplored immunomodulatory contributions to this disease process...
  92. pmc The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor
    Barbara Ghinassi
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Blood 109:1460-71. 2007
    Recent evidence suggests that mutations in the Gata1 gene may alter the proliferation/differentiation potential of hemopoietic progenitors...
  93. ncbi Novel binding partners of Ldb1 are required for haematopoietic development
    Natalia Meier
    Department of Cell Biology and Genetics, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Development 133:4913-23. 2006
    ..It interacts with Gata1, Tal1, E2A and Lmo2 to form a transcription factor complex regulating late erythroid genes...
  94. ncbi Dynamic regulation of Gata factor levels is more important than their identity
    Rita Ferreira
    Department of Cell Biology, Erasmus MC, Rotterdam, The Netherlands
    Blood 109:5481-90. 2007
    Three Gata transcription factors (Gata1, -2, and -3) are essential for hematopoiesis. These factors are thought to play distinct roles because they do not functionally replace each other...
  95. ncbi GATA-1 self-association controls erythroid development in vivo
    Ritsuko Shimizu
    Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tennoudai 1 1 1, Tsukuba 305 8577, Japan
    J Biol Chem 282:15862-71. 2007
    ..We generated transgenic mouse lines that express these GATA-1 mutants utilizing the Gata1 hematopoietic regulatory domain, and crossed the mice to Gata1 knockdown (GATA-1.05) mutant mice...
  96. pmc STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice
    Zan Huang
    Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Clin Invest 117:3890-9. 2007
    ..We previously reported that STAT1 expression was significantly downregulated in Gata1-knockdown murine megakaryocytes, which also have impaired terminal maturation...
  97. doi Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis
    Laura Gutierrez
    Department of Cell Biology, Erasmus Medical College, Rotterdam, The Netherlands
    Blood 111:4375-85. 2008
    The transcription factor Gata1 is expressed in several hematopoietic lineages and plays essential roles in normal hematopoietic development during embryonic stages...
  98. pmc Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site
    Susanna Harju-Baker
    Department of Biochemistry and Molecular Biology, MS 3030, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Mol Cell Biol 28:3101-13. 2008
    ....
  99. doi GATA1-related leukaemias
    Ritsuko Shimizu
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Nat Rev Cancer 8:279-87. 2008
    b>GATA1 is a prototypical lineage-restricted transcription factor that is central to the correct differentiation, proliferation and apoptosis of erythroid and megakaryocytic cells...
  100. pmc Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif
    Yong Cheng
    Center for Comparative Genomics and Bioinformatics of the Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genome Res 18:1896-905. 2008
    ..activity to identify DNA segments within a 66-Mb region of mouse chromosome 7 that are occupied by the erythroid transcription factor GATA1...
  101. pmc Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes
    Stefania Bottardi
    Maisonneuve Rosemont Hospital Research Center, Maisonneuve Rosemont Hospital, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 29:1526-37. 2009
    ..Since the absence of Ikaros also affects GATA-1 recruitment to GATA-2 promoter, we propose that the combinatorial effect of Ikaros and GATA-1 is not restricted to globin gene regulation...

Research Grants13

  1. GATA-3 in precursor commitment to the T lineage
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..Definition of mechanistic requirements for GATA-3 perturbation of T-cell development 3. Attempted rescue of GATA-3 overexpression effects by cotransduction with targets of specific repression ..
  2. Embryonic hematopoietic stem cell origin and ontogeny
    James Palis; Fiscal Year: 2004
    ..A better understanding of the initiation of mammalian hematopoiesis will provide insights into the ontogeny, regulation and expansion of HSCs, as well as the origin of leukemias and bone marrow failure syndromes. ..
  3. Regulatory Pathways In Megakaryocyte Differentiation
    Adam Goldfarb; Fiscal Year: 2006
    ..Both cell line model systems and primary hematopoietic progenitor cells will be employed for these studies. ..
  4. Involvement of RUNX1 in Megakaryocytic Differentiation
    Adam Goldfarb; Fiscal Year: 2007
    ..abstract_text> ..
  5. Involvement of RUNX1 in Megakaryocytic Differentiation
    Adam Goldfarb; Fiscal Year: 2008
    ..Aim II will further explore the model in murine model systems of megakaryopoiesis, employing GATA-1 and RUNX1 knockout strains. ..
  6. Application for a Fluorescence-Activated Cell Sorter
    ELLEN ROTHENBERG; Fiscal Year: 2003
    ..This application is to replace the old sorter with a new sorter that will improve service to existing clients and permit the Facility to carry out new flow cytometric applications that have not been available to the user group before. ..
  7. FOG1 AND HEMATOPOIESIS
    Alan Cantor; Fiscal Year: 2003
    ..abstract_text> ..
  8. Initiation of Mammalian Yolk Sac Hematopoiesis
    James Palis; Fiscal Year: 2006
    ..This will ultimately lead to improvements in bone marrow transplantation for the curative treatment of congenital anemias, genetic diseases and several forms of childhood and adult cancers. ..
  9. Proteomic Study of Megakaryocyte Transcriptional Control
    Alan Cantor; Fiscal Year: 2007
    ..The results of this study should provide new insights into the transcriptional regulation of megakaryopoiesis, and possibly new therapeutic targets for disorders of megakaryocyte proliferation and development. ..
  10. CIS-REGULATORY ANALYSIS OF PU.1 BY IN VITRO ES CELL DIFFERENTIATION
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..This should permit faster and cheaper experiments to reveal how powerful regulatory genes are themselves controlled. [unreadable] [unreadable]..
  11. Proteomic Approach to Further Understanding the Role of*
    Alan Cantor; Fiscal Year: 2008
    ..These studies should provide important insights that will facilitate the design of novel therapies for MDS. ..
  12. Ontogeny of erythroid lineage differentiation
    James Palis; Fiscal Year: 2010
    ..These studies will improve our understanding of the causes of anemia and will ultimately lead to curative treatments for children and adults with sickle cell disease and thalassemia syndromes. ..
  13. LINEAGE ANALYSIS OF FUNCTION IN MURINE LYMPHOCYTES
    ELLEN ROTHENBERG; Fiscal Year: 2004
    ....