Gast

Summary

Gene Symbol: Gast
Description: gastrin
Alias: GAS, gastrin
Species: mouse

Top Publications

  1. ncbi Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice
    D Chen
    Department of Surgery and Laboratory Medicine, Trondheim University Hospital, Trondheim, Norway
    Gastroenterology 119:756-65. 2000
  2. ncbi Interferon gamma induction of gastric mucous neck cell hypertrophy
    Weiqun Kang
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Lab Invest 85:702-15. 2005
  3. pmc Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, New York, USA
    Am J Pathol 175:365-75. 2009
  4. pmc Induction of follistatin precedes gastric transformation in gastrin deficient mice
    Weiqun Kang
    Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB 2051, Ann Arbor, MI 48109 2200, USA
    Biochem Biophys Res Commun 376:573-7. 2008
  5. pmc Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing
    Hiroyuki Tomita
    Division of Digestive and Liver Disease, Irving Cancer Research Center, Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    Gastroenterology 140:879-91. 2011
  6. ncbi Gastrin stimulates the growth of gastric pit cell precursors by inducing its own receptors
    Toshio Nakajima
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G359-66. 2002
  7. pmc Arx is required for normal enteroendocrine cell development in mice and humans
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, USA
    Dev Biol 365:175-88. 2012
  8. ncbi Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
    T C Wang
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 118:36-47. 2000
  9. ncbi Lessons from genetically engineered animal models. I. Physiological studies with gastrin in transgenic mice
    T C Wang
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Physiol 277:G6-11. 1999
  10. ncbi Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma
    Yana Zavros
    Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Oncogene 24:2354-66. 2005

Research Grants

  1. Stem Cells and Gastric Cancer
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
  2. 14th International Symposium on Regulatory Peptides
    Timothy Wang; Fiscal Year: 2002
  3. FUNCTION AND REGULATION OF GASTRIN
    Timothy Wang; Fiscal Year: 2008

Scientific Experts

  • Lennart Friis-Hansen
  • T C Wang
  • Maarten van den Buuse
  • Qian Li
  • S A Watson
  • Wolfgang Engel
  • Clifton M Ramsdell
  • Suzana Kovac
  • Jens Hannibal
  • Linda C Samuelson
  • Shigeo Takaishi
  • Yana Zavros
  • Juanita L Merchant
  • Ramesh A Shivdasani
  • Renu N Jain
  • Weiqun Kang
  • Andrea Varro
  • Byeong Moo Kim
  • Rui Feng
  • Yu Chun Lu
  • Hiroyuki Tomita
  • Milena Saqui-Salces
  • James R Goldenring
  • T J Koh
  • Kelly S Betz
  • G J Dockray
  • Arthur Shulkes
  • Shuiping Tu
  • T V Franic
  • Pomila Singh
  • Eunyoung Choi
  • Chenura D Jayewickreme
  • Gerard Gradwohl
  • Guanglin Cui
  • Jing Li
  • Jessica M Donnelly
  • Yoshio Fujitani
  • Daniel F Boyer
  • Wandong Ai
  • Yaron Suissa
  • James M Wells
  • Aiping Du
  • A Varro
  • CATHERINE LEE MAY
  • Guangchun Jin
  • Xiangdong Yang
  • Katrin Arnold
  • J M Salbaum
  • Wataru Shibata
  • Pragnya Das
  • Andrew S Giraud
  • Marjorie Jenny
  • Duan Chen
  • Anthony J Peterson
  • JeanMarie Houghton
  • Toshio Nakajima
  • Chun Mei Zhao
  • Georg Mellitzer
  • C M Kirton
  • Meghna Waghray
  • Gail L Matters
  • Koji Nozaki
  • Shahid Umar
  • Yu Cheng Wang
  • Michael P Verzi
  • W Goering
  • Hiroshi Kokubu
  • Sara Edfalk
  • Vinciane Vanhorenbeeck
  • Louise M Judd
  • Ian R van Driel
  • Julie Pannequin
  • Catherine S Chew
  • Graham S Baldwin
  • A Bradley
  • Enrique Rozengurt
  • D Mark Pritchard
  • Christopher V E Wright
  • Albert J Chang
  • Tomas Alanentalo
  • Maureen Gannon
  • Roland W Stein
  • Michele Kedinger
  • Elena Zhukova
  • Kelly A Smith
  • Naoki Kanda
  • Penelope D Ottewell
  • Abhijit Chakladar
  • P D Ottewell
  • Theodore J Koh

Detail Information

Publications93

  1. ncbi Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice
    D Chen
    Department of Surgery and Laboratory Medicine, Trondheim University Hospital, Trondheim, Norway
    Gastroenterology 119:756-65. 2000
    Studies in gastrin-deficient mice have demonstrated critical roles for gastrin peptides in the regulation of gastric acid secretion, but the relative contributions of amidated (G-17) and glycine-extended (G17-Gly) gastrin remain unclear...
  2. ncbi Interferon gamma induction of gastric mucous neck cell hypertrophy
    Weiqun Kang
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Lab Invest 85:702-15. 2005
    ..In gastrin-deficient (G-/-) mice exhibiting chronic inflammation in the hypochlorhydric stomach, we documented a prominent ..
  3. pmc Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, New York, USA
    Am J Pathol 175:365-75. 2009
    ..However, gastrin-deficient (GAS-KO) mice on a mixed C57BL/6/129Sv genetic background maintained in conventional housing were ..
  4. pmc Induction of follistatin precedes gastric transformation in gastrin deficient mice
    Weiqun Kang
    Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB 2051, Ann Arbor, MI 48109 2200, USA
    Biochem Biophys Res Commun 376:573-7. 2008
    We previously showed that antral gastric tumors develop in gastrin-deficient (Gas(-/-)) mice. Therefore Gas(-/-) mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation...
  5. pmc Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing
    Hiroyuki Tomita
    Division of Digestive and Liver Disease, Irving Cancer Research Center, Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    Gastroenterology 140:879-91. 2011
    ..Although hormones have been associated with cancer risk, the mechanisms have not been determined. The peptide hormone gastrin exerts a suppressive effect on antral gastric carcinogenesis.
  6. ncbi Gastrin stimulates the growth of gastric pit cell precursors by inducing its own receptors
    Toshio Nakajima
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G359-66. 2002
    b>Gastrin/CCK-B receptors (CCKB-Rs) are present on parietal and enterochromaffin-like cells in the gastric mucosa but not on pit cells in the proliferative zone...
  7. pmc Arx is required for normal enteroendocrine cell development in mice and humans
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, USA
    Dev Biol 365:175-88. 2012
    ..mice, removal of Arx from the developing endoderm results in a decrease of enteroendocrine cell types including gastrin-, glucagon/GLP-1-, CCK-, secretin-producing cell populations and an increase of somatostatin-expressing cells...
  8. ncbi Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
    T C Wang
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 118:36-47. 2000
    ..Hypergastrinemia occurs frequently in association with acid suppression and Helicobacter infection, but its role in the progression to gastric atrophy and gastric cancer has not been well defined...
  9. ncbi Lessons from genetically engineered animal models. I. Physiological studies with gastrin in transgenic mice
    T C Wang
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Physiol 277:G6-11. 1999
    The role of gastrin in the regulation of gastrointestinal growth and acid secretion has been addressed through recent studies involving transgenic and knockout mice...
  10. ncbi Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma
    Yana Zavros
    Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Oncogene 24:2354-66. 2005
    The current study tests the hypothesis that chronic atrophic gastritis from hypochlorhydria in the gastrin-deficient mouse predisposes the stomach to gastric cancer...
  11. ncbi Impaired gastric acid secretion in gastrin-deficient mice
    L Friis-Hansen
    Department of Physiology, University of Michigan, Ann Arbor 48109, USA
    Am J Physiol 274:G561-8. 1998
    To further understand the role of the peptide hormone gastrin in the development and function of the stomach, we have generated gastrin-deficient mice by gene targeting in embryonic stem cells...
  12. pmc In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Dept of Medicine, Columbia Univ Medical Center, 1130 St Nicholas Ave, ICRC 923, New York, NY, USA
    Am J Physiol Gastrointest Liver Physiol 300:G334-44. 2011
    b>Gastrin is secreted from a subset of neuroendocrine cells residing in the gastric antrum known as G cells, but low levels are also expressed in fetal pancreas and intestine and in many solid malignancies...
  13. doi Mash1 is required for neuroendocrine cell development in the glandular stomach
    Hiroshi Kokubu
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Cells 13:41-51. 2008
    ..bHLH gene Neurogenin3 (Ngn3), which is known to regulate formation of subsets of gastric neuroendocrine cells (gastrin-, glucagon- and somatostatin-producing cells), is expressed normally in the Mash1-null stomach...
  14. ncbi Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation
    Yana Zavros
    Department of Internal Medicine Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:33265-74. 2007
    ..b>Gastrin is the only hormone capable of stimulating gastric acid and is thus required to maintain functional parietal ..
  15. pmc Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells
    T C Wang
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    J Clin Invest 92:1349-56. 1993
    b>Gastrin is transiently expressed in fetal islets during a critical period of their development from protodifferentiated islet precursors in fetal pancreatic ducts...
  16. ncbi Insulin-promoter-factor 1 is required for pancreas development in mice
    J Jonsson
    Department of Microbiology, University of Umea, Sweden
    Nature 371:606-9. 1994
    ..These findings show that IPF1 is needed for the formation of the pancreas and suggest that it acts to determine the fate of common pancreatic precursor cells and/or to regulate their propagation...
  17. pmc Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
    Marjorie Jenny
    INSERM U381, 3 avenue Moliere, 67200, Strasbourg, France
    EMBO J 21:6338-47. 2002
    ..In contrast, in the glandular stomach, the differentiation of the gastrin- (G cells) and somatostatin (D cells)-secreting cells is impaired whereas serotonin- (enterochromaffin EC cells), ..
  18. doi Loss of RegI in conjunction with gastrin deficiency in mice facilitates efficient gastric ulcer healing but is dispensable for hyperplasia and tumourigenesis
    Anthony J Peterson
    GRIP Lab Gastrointestinal Research, Inflammation and Pathology, Murdoch Children s Research Institute, Parkville 3052, Australia
    Regul Pept 160:9-18. 2010
    ..We found that epithelial repair of acetic acid ulcers in compound mutant RegI/gastrin-deficient mice was significantly reduced compared to wild type, RegI-deficient or gastrin-deficient mice...
  19. ncbi Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene
    Robin P Boushey
    Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 125:1164-74. 2003
    Both cholecystokinin (CCK)-A and CCK-B receptors are expressed in the pancreas, and exogenous gastrin administration stimulates glucagon secretion from human islets...
  20. pmc Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to parietal cell loss is regulated by gastrin
    Eunyoung Choi
    Section of Surgical Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee Nashville VA Medical Center, Nashville, Tennessee
    Am J Pathol 185:2219-31. 2015
    ..More important, expansion of MVSCs after induced parietal cell loss was not observed in Gast(-/-) mice...
  21. ncbi Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Norweigian University of Science and Technology, Trondheim, Norway
    Gastroenterology 126:476-87. 2004
    Three pathways control gastric acid secretion: the gastrin-enterochromaffin-like (ECL) cell axis, the vagus-parietal cell axis, and the cholecystokinin (CCK)-D cell axis...
  22. ncbi Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice
    Sachiyo Nomura
    Nashville VA Medical Center, Department of Surgery, Epithelial Biology Program, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Gastrointest Liver Physiol 288:G362-75. 2005
    ..the alterations in gastric mucosal lineages elicited by acute oxyntic atrophy induced by treatment of C57BL/6 and gastrin-deficient mice with the parietal cell protonophore [S-(R*,S*)]-N-[1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-..
  23. ncbi Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes
    Yu Chun Lu
    Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California, Los Angeles, California 90095 1786, USA
    Endocrinology 146:2610-9. 2005
    ..We generated transgenic mice in which the coding sequence of human insulin has been knocked into the mouse gastrin gene...
  24. ncbi Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment
    Abhijit Chakladar
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Biochem Biophys Res Commun 336:190-6. 2005
    ..The gastrin gene encodes for a family of peptide growth factors that are commonly upregulated in colorectal neoplasia...
  25. pmc Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation
    Yoshio Fujitani
    Vanderbilt Program in Developmental Biology and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Genes Dev 20:253-66. 2006
    ....
  26. ncbi Gastric inflammation, metaplasia, and tumor development in gastrin-deficient mice
    Lennart Friis-Hansen
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Gastroenterology 131:246-58. 2006
    b>Gastrin deficiency and proton pump inhibitor treatment cause achlorhydria, which predisposes to disease. To elucidate the underlying molecular biology, we examined the changes in gastric gene expression in both types of achlorhydria...
  27. pmc Expression analysis of the Islet-1 gene in the developing and adult gastrointestinal tract
    Pragnya Das
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Gene Expr Patterns 11:244-54. 2011
    ....
  28. pmc Mesenchymal stem cells induce epithelial proliferation within the inflamed stomach
    Jessica M Donnelly
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio
    Am J Physiol Gastrointest Liver Physiol 306:G1075-88. 2014
    ..wild-type MSCs overexpressing Shh (wtMSC(Shh)), stMSC(vect), or stMSC(ShhKO) cells in C57BL/6 control (BL/6) or gastrin-deficient (GKO) mice was performed and mice analyzed 30 and 60 days posttransplantation...
  29. ncbi Regulation of gastric epithelial cell development revealed in H(+)/K(+)-ATPase beta-subunit- and gastrin-deficient mice
    T V Franic
    Department of Pathology and Immunology, Monash University Medical School, Alfred Hospital, Melbourne, Victoria, Australia 3181
    Am J Physiol Gastrointest Liver Physiol 281:G1502-11. 2001
    ..The effect of elevated gastrin levels in the H/K-beta-deficient mice was determined by producing mice that are also deficient in gastrin...
  30. ncbi PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes
    E Kandil
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan
    Immunogenetics 46:337-44. 1997
    ..It appears that the IFN-gamma-inducible alpha- and beta-subunits emerged by gene duplication from a gamma-subunit-like precursor...
  31. pmc Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas
    Yaron Suissa
    Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 8:e70397. 2013
    ..b>Gastrin is a hormone produced primarily by G-cells in the stomach, where it functions to stimulate acid secretion by ..
  32. pmc Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1
    Chenura D Jayewickreme
    Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
    Dev Biol 405:21-32. 2015
    ..The sum of evidence suggests that potent BARX1 functions in intestinal rotation and stomach myogenesis occur through this small group of intermediary transcription factors. ..
  33. pmc Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice
    Rui Feng
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio
    Gastroenterology 147:655-666.e9. 2014
    ..We investigated whether hypergastrinemia induces gastric epithelial proliferation by activating Ihh signaling in mice...
  34. pmc Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice
    Katrin Arnold
    Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, MA 02138, USA
    Cell Stem Cell 9:317-29. 2011
    ..Thus, our results identify Sox2 expression in numerous adult endodermal and ectodermal stem cell compartments, which are critical for normal tissue regeneration and survival...
  35. pmc Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia
    Milena Saqui-Salces
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e48039. 2012
    Chronic inflammation in the stomach can lead to gastric cancer. We previously reported that gastrin-deficient (Gast⁻/⁻) mice develop bacterial overgrowth, inflammatory infiltrate, increased Il-1β expression, antral hyperplasia and ..
  36. ncbi Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation
    Vinciane Vanhorenbeeck
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Dev Biol 305:685-94. 2007
    ..In conclusion, our data reveal partially redundant roles for HNF-6 and OC-2 in developing pancreas and identify new markers for antero-posterior patterning of the gut and for enteroendocrine differentiation...
  37. pmc Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
    Sara Edfalk
    Umeå Center for Molecular Medicine, University of Umea, Umea, Sweden
    Diabetes 57:2280-7. 2008
    ..Here, we addressed whether 1) Gpr40 is expressed in the intestine and 2) Ipf1/Pdx1 function is required for Gpr40 expression...
  38. ncbi Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors
    Julie Pannequin
    CNRS UMR5203, Montpellier, France
    Gastroenterology 133:1554-68. 2007
    ....
  39. pmc Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells
    Michael P Verzi
    Dana Farber Cancer Institute and Department of Medicine, Boston, Massachusetts, USA
    Gastroenterology 135:591-600. 2008
    ..We identified stomach-restricted expression of the forkhead transcription factor FOXQ1...
  40. ncbi Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways
    Shuiping Tu
    Division of Digestive and Liver Diseases, Dept of Medicine, College of Physicians and Surgeons, Columbia Univ, 1130 St Nicholas Ave, Rm 925, 9th Fl, New York, NY 10032, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1726-37. 2007
    ..The peptide hormone, gastrin, stimulates acid secretion but also induces proliferation of the acid-secreting mucosa...
  41. ncbi Transgenic insulin released from G cells preferentially signals in the liver
    Yu Chun Lu
    Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA and CURE Digestive Diseases Research Center, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 355:23-7. 2007
    ..G-InsKi mice provide a novel animal model for elucidating direct effects of insulin on liver functions...
  42. ncbi Gene expression profiling of gastrin target genes in parietal cells
    Renu N Jain
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 0622, USA
    Physiol Genomics 24:124-32. 2006
    Previous studies demonstrated that mice with a null mutation in the gene encoding the hormone gastrin have impaired gastric acid secretion...
  43. ncbi Significant increase in the aggressive behavior of transgenic mice overexpressing peripheral progastrin peptides: associated changes in CCK2 and serotonin receptors in the CNS
    Qian Li
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555 0431, USA
    Neuropsychopharmacology 32:1813-21. 2007
    The gastrin precursor peptide, progastrin (PG), is secreted from enteroendocrine cells in the intestine and increased in patients with hypergastrinemia and colorectal cancers...
  44. ncbi Achlorhydria is associated with gastric microbial overgrowth and development of cancer: lessons learned from the gastrin knockout mouse
    L Friis-Hansen
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Clin Lab Invest 66:607-21. 2006
    b>Gastrin and gastrin receptor-deficient mice have been used for genetic dissection of the role of gastrins in maintaining gastric homeostasis and control of acid secretion...
  45. pmc Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice
    Renu N Jain
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    J Clin Invest 118:2459-70. 2008
    ..Hip1r-deficient mice had increased expression of the gastric growth factor gastrin, and mice mutant for both gastrin and Hip1r exhibited normalization of both proliferation and gland height...
  46. doi Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice
    W Goering
    Institute of Human Genetics, University of Gottingen, Gottingen, Germany
    Cytogenet Genome Res 121:88-95. 2008
    ..Ultrastructural analysis suggests that the gastric acid secretion defect in Foxq1-deficient mice might be due to impairment in the fusion of cytoplasmic tubulovesicles to the apical membrane of secretory canaliculi...
  47. pmc Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival
    Georg Mellitzer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U964, CNRS UMR 7104, Universite de Strasbourg, Illkirch, France
    J Clin Invest 120:1708-21. 2010
    ..Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium...
  48. pmc Interrelationships between circulating gastrin and iron status in mice and humans
    Suzana Kovac
    Univ of Melbourne Dept of Surgery, Austin Health, Studley Rd, Heidelberg, Victoria 3084, Australia
    Am J Physiol Gastrointest Liver Physiol 295:G855-61. 2008
    The observations that the peptide hormone gastrin interacts with transferrin in vitro and that circulating gastrin concentrations are increased in the iron-loading disorder hemochromatosis suggest a possible link between gastrin and iron ..
  49. pmc Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency
    Suzana Kovac
    University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia
    Endocrinology 152:3062-73. 2011
    ..We have previously demonstrated that ferric ions bind to gastrins, that the gastrin-ferric ion complex interacts with the iron transport protein transferrin in vitro, and that circulating gastrin ..
  50. pmc Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy
    J M Salbaum
    Laboratory of Regulation of Gene Expression, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Diabetologia 54:1909-20. 2011
    ..g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental function, and sought to identify cellular and molecular abnormalities in diabetic placenta...
  51. doi Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors
    Yu Cheng Wang
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Endocr Relat Cancer 16:267-79. 2009
    ..mice, we found a dramatic reduction in the number of cells producing numerous hormones, such as serotonin, gastrin, cholecystokinin, somatostatin, glucagon-like peptide 1 (GLP-1), and secretin, but an increase in cells producing ..
  52. pmc Altered gastric chief cell lineage differentiation in histamine-deficient mice
    Koji Nozaki
    Vanderbilt Univ Sch of Medicine, Dept of Surgery, Epithelial Biology Center, MRBIV Bm 10435G, 2213 Garland Ave, Nashville, TN 37232, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1211-20. 2009
    ..Mice dually deficient for both HDC and gastrin showed a normal distribution of chief cells in fundic glands...
  53. pmc Growth of human pancreatic cancer is inhibited by down-regulation of gastrin gene expression
    Gail L Matters
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17011, USA
    Pancreas 38:e151-61. 2009
    This study evaluated the effects of gastrin messenger RNA (mRNA) down-regulation on growth of human pancreatic cancer.
  54. pmc Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin
    Shahid Umar
    Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 284:22274-84. 2009
    ..Our studies suggest a novel possibility that activation of beta-catenin, downstream to the IKKalpha,beta/NFkappaB pathway, may be integral to the hyperproliferative effects of progastrin on proximal colonic crypts...
  55. pmc Regulation of mouse stomach development and Barx1 expression by specific microRNAs
    Byeong Moo Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Development 138:1081-6. 2011
    ..These results indicate that miRNAs are required for proper digestive tract organogenesis and that miR-7a and miR-203 control expression of the stomach homeotic regulator Barx1...
  56. doi Cholecystokinin (CCK)-expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK-deficient mice
    Jens Hannibal
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Eur J Neurosci 32:1006-17. 2010
    ....
  57. ncbi Gastrin regulates the heparin-binding epidermal-like growth factor promoter via a PKC/EGFR-dependent mechanism
    Natalie F Sinclair
    University of Massachusetts Memorial Medical Center, Division of Digestive Diseases and Nutrition, Worcester, 01655, USA
    Am J Physiol Gastrointest Liver Physiol 286:G992-9. 2004
    b>Gastrin is a known growth/differentiation factor for the gastric mucosa...
  58. ncbi Sequences responsible for transcription termination of the mouse gastrin gene
    M J Noh
    Department of Life Science, Korea Advanced Institute of Science and Technology, Taejon
    Biochem Mol Biol Int 35:1205-13. 1995
    To identify the transcription termination elements in the mouse gastrin gene, we examined RNA transcripts after stable transfection of gastrin expression plasmids into the NIH3T3 cell line...
  59. pmc G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo
    A Nagata
    Department of Medicine, Kobe University School of Medicine, Japan
    Proc Natl Acad Sci U S A 93:11825-30. 1996
    ..Here we have generated G protein-coupled cholecystokinin (CCK)-B/gastrin receptor deficient-mice by gene targeting...
  60. ncbi Disturbed progastrin processing in carboxypeptidase E-deficient fat mice
    K A Lacourse
    Department of Physiology, University of Michigan, Ann Arbor 48109 0622, USA
    FEBS Lett 416:45-50. 1997
    ..Since CPE plays a central role in the biosynthesis of a number of regulatory peptides, including gastrin, we examined the biogenesis and processing of progastrin in fat/fat mice by measuring gastrin mRNA, ..
  61. pmc Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11
    P Liu
    Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 150:1155-68. 1998
    ..A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality...
  62. ncbi Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    Q Yang
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 294:2155-8. 2001
    ..The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment...
  63. ncbi Immunocytochemical detection of orexin A in endocrine cells of the developing mouse gut
    María J Sánchez de Miguel
    Department of Histology and Pathology, University of Navarra, Pamplona, Spain
    J Histochem Cytochem 50:63-9. 2002
    ..These findings suggest that orexin A may be relevant in the growth and maturation of the gastrointestinal tract during intrauterine life...
  64. ncbi Gastrin interferes with the differentiation of gastric pit cells and parietal cells
    T Nakajima
    Division of Gastroenterology and Hepatology, Kyoto University, Graduate School of Medicine, Sakyo ku 606 8507, Japan
    Aliment Pharmacol Ther 16:3-9. 2002
    b>Gastrin is known to have stimulatory effects on gastric mucosa; however, long-term effect of gastrin stimulation is not well known.
  65. pmc Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence
    S A Watson
    Academic Unit of Cancer Studies, University of Nottingham, Nottingham, NG7 2UH, UK
    Br J Cancer 87:567-73. 2002
    ..5 kDa. Omeprazole and lansoprazole-induced hyper-gastrinaemia (resulting in serum gastrin levels of 34.0 and 153...
  66. ncbi Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice
    Karen L Hinkle
    Department of Physiology, University of Michigan, Ann Arbor 48109 0622, USA
    Am J Physiol Gastrointest Liver Physiol 284:G145-53. 2003
    b>Gastrin-deficient mice have impaired basal and agonist-stimulated gastric acid secretion...
  67. ncbi Chronic Helicobacter pylori infection results in gastric hypoacidity and hypergastrinemia in wild-type mice but vagally induced hypersecretion in gastrin-deficient mice
    Chun Mei Zhao
    Departments of Cancer Research and Molecular Medicine and Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Regul Pept 115:161-70. 2003
    ..Parietal cells and ECL cells in the stomach are controlled by gastrin, which plays a crucial role in the regulation of acid secretion...
  68. pmc Circulating gastrin is increased in hemochromatosis
    Kelly A Smith
    University of Melbourne Department of Surgery, Austin Health, Level 8, Lance Townsend Building, Studley Road, Heidelberg, VIC 3084, Australia
    FEBS Lett 580:6195-8. 2006
    Gastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively...
  69. ncbi Acidic duodenal pH alters gene expression in the cystic fibrosis mouse pancreas
    Simran Kaur
    Dept of Anatomy and Cell Biology, Univ of Kansas School of Medicine, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 287:G480-90. 2004
    ..When the duodenal pH was corrected genetically (crossing CFTR null with gastrin null mice) or pharmacologically (use of the proton pump inhibitor omeprazole), expression levels of genes ..
  70. ncbi Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritis
    Teo V Franic
    The Russell Grimwade School of Biochemistry and Molecular Biology, The Univ of Melbourne, Melbourne, VIC 3010, Australia
    Am J Physiol Gastrointest Liver Physiol 287:G910-8. 2004
    ..Here, we examined factors that may be responsible for inducing this hypertrophy. Because gastrin is known to be both an inducer of gastric mucosal cell proliferation and is elevated in autoimmune gastritis, ..
  71. ncbi COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo
    P D Ottewell
    Deptartment of Medicine, 5th Fl UCD Bldg, Daulby St, Liverpool L69 3BX, UK
    Am J Physiol Gastrointest Liver Physiol 288:G541-9. 2005
    ..whether the effects of progastrin observed in hGAS colon require the presence of other forms of circulating gastrin, we have crossed hGAS (hg(+/+)) with gastrin knockout (G(-/-)) mice to generate mice that express progastrin and ..
  72. ncbi Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development
    Tomas Alanentalo
    Umeå Centre for Molecular Medicine, UCMM, Umea University, S 901 87 Umea, Sweden
    Gene Expr Patterns 6:162-70. 2006
    ..2 both in the CNS and in the gut. Transient Nkx6.2 expression was also detected in the developing pancreas. However, analysis of Nkx6.2(-/-) mice did not display any obvious aberrations of pancreatic or stomach development...
  73. ncbi Gastrin-induced apoptosis contributes to carcinogenesis in the stomach
    Guanglin Cui
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Lab Invest 86:1037-51. 2006
    ..We investigated the possible role of gastrin-induced gastric cell apoptosis in the development of gastric cancer...
  74. ncbi Gastrin increases murine intestinal crypt regeneration following injury
    Penelope D Ottewell
    Division of Gastroenterology, University of Liverpool, Liverpool, UK
    Gastroenterology 130:1169-80. 2006
    ..of growth factors affect the regeneration of intestinal epithelia following injury, but the effects of amidated gastrin have not previously been assessed...
  75. ncbi Attenuation of peroxisome proliferator-activated receptor gamma (PPARgamma) mediates gastrin-stimulated colorectal cancer cell proliferation
    Albert J Chang
    Section of Gastroenterology, Boston University School of Medicine and Boston Medical Center, 650 Albany Street, Boston, MA 02118, USA
    J Biol Chem 281:14700-10. 2006
    ..has been shown to suppress cell proliferation and tumorigenesis, whereas the gastrointestinal regulatory peptide gastrin stimulates the growth of neoplastic cells...
  76. ncbi Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci
    Clifton M Ramsdell
    Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, South Carolina 29208, USA
    Mamm Genome 17:37-48. 2006
    ..Furthermore, this separate linkage group is likely to reside in a chromosomal region of inversion polymorphism between P. maniculatus and P. polionotus...
  77. ncbi Molecular cloning and sequencing of the murine gastrin gene
    T J Koh
    Gastrointestinal Unit, Massachusetts General Hospital, Boston 02114, USA
    Biochem Biophys Res Commun 216:34-41. 1995
    b>Gastrin is a peptide hormone important in acid regulation, growth of enterochromaffin cells of the oxyntic mucosa, and smooth muscle contractility. We isolated a genomic clone of gastrin from a SV-129 murine genomic library...
  78. ncbi Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice
    Naoki Kanda
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin Kawara cho 54, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 290:G519-27. 2006
    b>Gastrin promotes gastric mucosal growth, and hypergastrinemia induces gastric mucosal hypertrophy. Recently, it has been reported that gastrin induces cyclooxygenase-2 (COX-2) in human gastric and colorectal cancer cell lines...
  79. pmc Direct regulation of intestinal fate by Notch
    Ben Z Stanger
    Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:12443-8. 2005
    ..In the embryo, Notch activation perturbs morphogenesis, possibly through effects on stem or progenitor cells...
  80. ncbi Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout mice
    Lennart Friis-Hansen
    Department of Clinical Biochemistry, KB 3011, Rigshospitalet, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Endocrinology 146:4464-71. 2005
    The antral hormone gastrin and its intestinal relative, cholecystokinin (CCK), are pivotal in the regulation of gastric functions...
  81. ncbi Reciprocal changes in trefoil 1 and 2 expression in stomachs of mice with gastric unit hypertrophy and inflammation
    T V Franic
    Department of Medicine, The University of Melbourne, Western Hospital, Melbourne, VIC 3011, Australia
    J Pathol 207:43-52. 2005
    ..Stomachs from both models expressed decreased TFF1 mRNA and reciprocally increased TFF2 mRNA. The involvement of gastrin in regulating trefoil mRNA expression was also investigated using gastrin-deficient mice...
  82. ncbi Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression
    Stephanie L Cowey
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1043, USA
    Cancer 103:2643-53. 2005
    The authors recently reported that gastrin gene knockout (GAS-KO) mice had an increased risk for colon carcinogenesis in response to azoxymethane (AOM) compared with their wild type (WT) littermates...
  83. ncbi Chromosome engineering in mice
    R Ramirez-Solis
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 378:720-4. 1995
    ..The availability of mice with defined regions of segmental haploidy will allow their use in genetic screens and enable accurate models of human 'chromosomal' diseases to be generated...
  84. ncbi Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Neurosci Lett 373:237-42. 2005
    The present study was aimed at investigating the role of gastrin in startle, startle habituation and prepulse inhibition (PPI)...
  85. ncbi Transcriptional profiling of gastrin-regulated genes in mouse stomach
    Renu N Jain
    Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Physiol Genomics 29:1-12. 2007
    b>Gastrin, a potent stimulator of gastric acid secretion, primarily targets the acid-secreting parietal cells and histamine-secreting enterochromaffin-like (ECL) cells in the stomach...
  86. pmc Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis
    T J Koh
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 106:533-9. 2000
    ..Previous studies have shown that the gene encoding the hormone gastrin is activated during colon cancer progression and the less-processed forms of gastrin are important colonic ..
  87. ncbi Nested chromosomal deletions induced with retroviral vectors in mice
    H Su
    Program in Developmental Biology, Department of Molecular Genetics, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 24:92-5. 2000
    ..Our approach can be extended to any region of the mouse genome...
  88. pmc Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation
    T J Koh
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 103:1119-26. 1999
    b>Gastrin is a peptide hormone involved in the growth of both normal and malignant gastrointestinal tissue...
  89. ncbi Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression
    Daniel F Boyer
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Dev Biol 298:616-31. 2006
    ..These results reveal a role for distal cis-regulatory elements in achieving the correct level of extra-pancreatic Pdx1 expression, which is necessary for the production of duodenal GIP cells and stomach gastrin cells.
  90. ncbi Lessons from the gastrin and gastrin receptor knockout mice
    L Friis-Hansen
    Dept of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Clin Lab Invest Suppl 234:41-6. 2001
    The gastric hormone gastrin was first recognized for its ability to induce acid secretion...
  91. ncbi BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1
    M Pershouse
    Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Genomics 69:139-42. 2000
    ..The region described is one of the targets of a large effort to create a series of mice with regional deletions on mouse chromosome 11 (33-80 cM) that can subsequently be subjected to further mutagenesis...
  92. ncbi Regulation of parietal cell migration by gastrin in the mouse
    C M Kirton
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 283:G787-93. 2002
    Recent studies suggest that gastrin regulates parietal cell maturation. We asked whether it also regulates parietal cell life span and migration along the gland...
  93. ncbi The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling
    Byeong Moo Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 8:611-22. 2005
    ..These results define a transcriptional and signaling pathway of inductive cell interactions in vertebrate organogenesis...

Research Grants3

  1. Stem Cells and Gastric Cancer
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
    ....
  2. 14th International Symposium on Regulatory Peptides
    Timothy Wang; Fiscal Year: 2002
    ..These peptides - which include not only gastrin/CCK and somatostatin, but also trefoils, TGF-¿ and TGF-¿, and cytokines - are of major importance in ..
  3. FUNCTION AND REGULATION OF GASTRIN
    Timothy Wang; Fiscal Year: 2008
    ..Studies from our group employing gastrin over-expressing and gastrin-deficient mice have demonstrated that progastrin or incompletely processed forms of ..