Gas2

Summary

Gene Symbol: Gas2
Description: growth arrest specific 2
Alias: Gas-2, growth arrest-specific protein 2
Species: mouse

Top Publications

  1. ncbi Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms
    S Fitter
    The Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Post Office Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia
    Biochim Biophys Acta 1398:75-85. 1998
  2. ncbi gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb
    K K Lee
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Dev Biol 207:14-25. 1999
  3. ncbi An integrated deletion and physical map encompassing l71Rl, a chromosome 7 locus required for peri-implantation survival in the mouse
    M Wu
    Life Sciences Division, University of Tennessee Oak Ridge, Oak Ridge, Tennessee 37831 8077, USA
    Genomics 67:228-31. 2000
  4. ncbi Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability
    Thomas M Williams
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Dev Biol 279:462-80. 2005
  5. ncbi The calpain system is involved in the constitutive regulation of beta-catenin signaling functions
    Roberta Benetti
    Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    J Biol Chem 280:22070-80. 2005
  6. doi GAS2-Calpain2 axis contributes to the growth of leukemic cells
    Lili Sun
    Cyrus Tang Hematology Center, Soochow University, Suzhou 215123, China
    Acta Biochim Biophys Sin (Shanghai) 47:795-804. 2015
  7. pmc Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus
    D K Johnson
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077, USA
    Genetics 141:1563-71. 1995
  8. ncbi Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice
    Akinobu Okada
    Drug Safety Research Laboratories, Astellas Pharma Inc, 2 1 6 Kashima, Yodogawa ku, Osaka 532 8514, Japan
    Birth Defects Res A Clin Mol Teratol 73:229-38. 2005
  9. ncbi A microsatellite map of the pink-eyed dilution (p) deletion complex in mouse chromosome 7
    M S Dhar
    University of Tennessee, Graduate School of Biomedical Sciences, Oak Ridge National Laboratory 37831 8077, USA
    Mamm Genome 8:143-5. 1997
  10. ncbi Expression of growth arrest-specific (Gas) genes in murine keratinocytes: Gas2 is specifically regulated
    S Manzow
    Biochemistry of Tissue Specific Regulation, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Exp Cell Res 224:200-3. 1996

Scientific Experts

  • S Fitter
  • D K Johnson
  • L B Russell
  • K K H Lee
  • Lili Sun
  • Roberta Benetti
  • Thomas M Williams
  • Akinobu Okada
  • C Brancolini
  • Hong Liu
  • Haixia Zhou
  • Yue Ge
  • Xiuyan Zhang
  • Wenjuan Ma
  • Depei Wu
  • Yun Zhao
  • M Wu
  • C Schneider
  • Tamara Copetti
  • Kiyoshi Kushima
  • Jeffrey W Innis
  • Claudio Schneider
  • Rork Kuick
  • Claudio Brancolini
  • Meir Bialer
  • Edon Melloni
  • Melissa E Williams
  • David Misek
  • Stefania Dell'orso
  • Kevin McDonagh
  • Michio Fujiwara
  • Samir Hanash
  • Martin Monte
  • Yoshinobu Aoki
  • M S Dhar
  • M F Seldin
  • S Manzow
  • A Orr-Urtreger
  • A Butler
  • E M Rinchik
  • K H Richter
  • F Marks
  • M P Colombo
  • J M Rochelle
  • A S Whitehead
  • A Baldini
  • A L Beaudet
  • M Benedetti
  • S Bottega
  • A Martinotti
  • T A Howard
  • P Baracetti
  • L Philipson
  • G Cairo
  • G Parmiani
  • R M King

Detail Information

Publications19

  1. ncbi Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms
    S Fitter
    The Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Post Office Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia
    Biochim Biophys Acta 1398:75-85. 1998
    ..Cd151 maps to chromosome 7, in close linkage to the p gene (OCA2 in humans), and helps define a boundary in the human/mouse homology relationships...
  2. ncbi gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb
    K K Lee
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Dev Biol 207:14-25. 1999
    The growth-arrest-specific 2 (gas2) gene was initially identified on account of its high level of expression in murine fibroblasts under growth arrest conditions, followed by downregulation upon reentry into the cell cycle (Schneider et ..
  3. ncbi An integrated deletion and physical map encompassing l71Rl, a chromosome 7 locus required for peri-implantation survival in the mouse
    M Wu
    Life Sciences Division, University of Tennessee Oak Ridge, Oak Ridge, Tennessee 37831 8077, USA
    Genomics 67:228-31. 2000
    ..This map defines the minimum critical interval for l71Rl as an 80- to 300-kb region. This sequence-ready deletion/physical map should enable the cloning and characterization of the l71Rl gene(s)...
  4. ncbi Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability
    Thomas M Williams
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Dev Biol 279:462-80. 2005
    ..Our results suggest that HOX protein-protein interactions without direct HOX DNA-binding may play a larger role in HOX transcriptional regulation than generally assumed, and DNA-binding appears critical for repression...
  5. ncbi The calpain system is involved in the constitutive regulation of beta-catenin signaling functions
    Roberta Benetti
    Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    J Biol Chem 280:22070-80. 2005
    ..We further characterized the role of the known calpain inhibitors, Gas2 and Calpastatin, demonstrating that they can also control levels, function, and localization of beta-catenin ..
  6. doi GAS2-Calpain2 axis contributes to the growth of leukemic cells
    Lili Sun
    Cyrus Tang Hematology Center, Soochow University, Suzhou 215123, China
    Acta Biochim Biophys Sin (Shanghai) 47:795-804. 2015
    Growth arrest specific 2 (GAS2) modulates cell cycle, apoptosis, and Calpain activity. GAS2-Calpain2 axis is required for the growth of BCR-ABL(+) hematopoietic cells and chronic myeloid leukemia cells...
  7. pmc Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus
    D K Johnson
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077, USA
    Genetics 141:1563-71. 1995
    ....
  8. ncbi Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice
    Akinobu Okada
    Drug Safety Research Laboratories, Astellas Pharma Inc, 2 1 6 Kashima, Yodogawa ku, Osaka 532 8514, Japan
    Birth Defects Res A Clin Mol Teratol 73:229-38. 2005
    ..However, the molecular mechanism of its teratogenesis is unknown. This study was conducted to investigate the genomewide effects of VPA disruption of normal neural tube development in mice...
  9. ncbi A microsatellite map of the pink-eyed dilution (p) deletion complex in mouse chromosome 7
    M S Dhar
    University of Tennessee, Graduate School of Biomedical Sciences, Oak Ridge National Laboratory 37831 8077, USA
    Mamm Genome 8:143-5. 1997
  10. ncbi Expression of growth arrest-specific (Gas) genes in murine keratinocytes: Gas2 is specifically regulated
    S Manzow
    Biochemistry of Tissue Specific Regulation, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Exp Cell Res 224:200-3. 1996
    ..gas1, gas5, and gas6 were found to be significantly expressed whereas there was a relatively low expression of gas2, gas3, and gas4...
  11. pmc Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse
    L B Russell
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077, USA
    Genetics 141:1547-62. 1995
    ..pl-1 does not mask preimplantation lethals between Gas2 and p; and no genes affecting survival are located between p and cp1...
  12. pmc Phosphorylation of the growth arrest-specific protein Gas2 is coupled to actin rearrangements during Go-->G1 transition in NIH 3T3 cells
    C Brancolini
    Laboratorio Nazionale Consorzio Interuniversitario, Biotecnologie, Area Science Park, Trieste, Italy
    J Cell Biol 124:743-56. 1994
    Growth arrest-specific (Gas2) protein has been shown to be a component of the microfilament system, that is highly expressed in growth arrested mouse and human fibroblasts and is hyperphosphorylated upon serum stimulation of quiescent ..
  13. ncbi The gene encoding the mouse serum amyloid A protein, apo-SAA5, maps to proximal chromosome 7
    A Butler
    Department of Genetics, Trinity College, University of Dublin, Ireland
    Immunogenetics 42:153-5. 1995
  14. ncbi Cloning and mapping of the mouse alpha 7-neuronal nicotinic acetylcholine receptor
    A Orr-Urtreger
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Genomics 26:399-402. 1995
    ..5 +/- 1.7 cM-Gas2-0.9 cM +/- 0.9 cM-D7Mit70-1.8 +/- 1.2 cM-Acra7-4.4 +/- 1.0 cM-Hras1-ps1/Igf1r/Snrp2a...
  15. pmc Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases
    C Brancolini
    LNCIB Laboratorio Nazionale Consorzio Interuniversitario Biotechnologie, Area Science Park, Trieste, Italy
    EMBO J 14:5179-90. 1995
    b>Gas2, a component of the microfilament system, belongs to the class of gas genes whose expression is induced at growth arrest...
  16. ncbi Genes specifically expressed at growth arrest of mammalian cells
    C Schneider
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 54:787-93. 1988
    ..Two cell lines transformed by viral onc genes did not express the two gas genes. The full-length cDNA for one gene has been sequenced and the protein product preliminarily characterized by in vitro translation...
  17. pmc A TaqI RFLP at the gas-2 locus
    M P Colombo
    Division of Experimental Oncology D, Istituto Nazionale Tumori, Milan, Italy
    Nucleic Acids Res 17:7545. 1989
  18. pmc Gas2, a growth arrest-specific protein, is a component of the microfilament network system
    C Brancolini
    International Center for Genetic Engineering and Biotechnology I C G E B Trieste, Italy
    J Cell Biol 117:1251-61. 1992
    In this report we analyze the protein product of a growth arrest-specific gene, gas2, by means of an affinity-purified antibody raised against the protein produced in bacteria...
  19. ncbi Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16
    M P Colombo
    Division of Experimental Oncology D, Istituto Nazionali Tumori, Milano, Italy
    Mamm Genome 2:130-4. 1992
    ..The six genes are unlinked. Gas-1 maps to Chromosome (Chr) 13, Gas-2 to Chr 7, Gas-3 to Chr 11, Gas-4 to Chr 16, Gas-6 to Chr 8, and Gas-10 to Chr 1...