Galk1

Summary

Gene Symbol: Galk1
Description: galactokinase 1
Alias: AA409894, GALK, Glk, Glk1, galactokinase, galactose kinase
Species: mouse

Top Publications

  1. ncbi Glk: a locus controlling galactokinase activity in the mouse
    J D Mishkin
    Biochem Genet 14:635-40. 1976
  2. pmc Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver
    F P Lemaigre
    Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium
    Biochem J 303:1-14. 1994
  3. ncbi The locus controlling pineal serotonin N-acetyltransferase activity (Nat-2) is located on mouse chromosome 11
    M Goto
    Department of Animal Physiology, Faculty of Agriculture, Nagoya University, Japan
    Brain Res Mol Brain Res 21:349-54. 1994
  4. ncbi Cloning and characterization of a mouse 3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase cDNA whose gene maps to chromosome 11
    B P Engelward
    Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115
    Carcinogenesis 14:175-81. 1993
  5. ncbi Mouse galactokinase: isolation, characterization, and location on chromosome 11
    Y Ai
    Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Genome Res 5:53-9. 1995
  6. ncbi Genetic mapping of the polycystic kidney gene, pcy, on mouse chromosome 9
    S Nagao
    Laboratory Animal Center, Fujita Health University, Aichi, Japan
    Biochem Genet 33:401-12. 1995
  7. ncbi Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene
    D A Altomare
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cytogenet Cell Genet 74:248-51. 1996
  8. ncbi Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5
    P Werner
    Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
    Genomics 42:74-82. 1997
  9. ncbi Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex
    R M Abdel-Majid
    Department of Anatomy and Neurobiology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Nat Genet 19:289-91. 1998
  10. ncbi A mouse model of galactose-induced cataracts
    Y Ai
    Department of Ophthalmology and Genetics, University of Pennsylvania, Room 313 Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Hum Mol Genet 9:1821-7. 2000

Scientific Experts

  • Chizuru Ito
  • Minoru Tomizawa
  • Shigeru Takeshita
  • Y Ai
  • Claire Yager
  • Fang Yang
  • Hidetoshi Kumagai
  • P A Doevendans
  • Masaki Takiguchi
  • Katsuro Iwase
  • Osamu Yokosuka
  • Kiyotaka Toshimori
  • Hiromitsu Saisho
  • Yoshiro Toyama
  • R M Abdel-Majid
  • Maki Moritani
  • Hiroshi Inoue
  • Kiyoshi Kunika
  • Mitsuo Itakura
  • D Stambolian
  • Cong Ning
  • Robert Reynolds
  • David B Rhoads
  • P Werner
  • Nancy Leslie
  • Tamar Agulian
  • Jason E Sudati
  • Stanton Segal
  • Lynne L Levitsky
  • Hideaki Nakajima
  • Toshiaki Kawakami
  • Yuko Kawakami
  • Neal G Copeland
  • Debra J Gilbert
  • Si Zhou Feng
  • Kaori Tamitsu
  • Toshihiko Oki
  • Masao Ono
  • Ying Chun Bao
  • Toshio Kitamura
  • Nancy A Jenkins
  • Kazunari Nagayoshi
  • D A Altomare
  • S Nagao
  • K Huang
  • S Kubalak
  • C Ning
  • Z Zheng
  • P R Lozano
  • R Bronsaer
  • M Van Bilsen
  • T Wynshaw-Boris
  • S Segal
  • A O'Brien-Jenkins
  • D J Bernard
  • R Reynolds
  • S T Wong
  • D R Storm
  • T Ito
  • W L Leong
  • A Fine
  • D S Smallman
  • D L Guernsey
  • M Goto
  • P E Neumann
  • F P Lemaigre
  • M J Dobson
  • E H Birkenmeier
  • L C Schalkwyk
  • C A Kozak
  • P S Henthorn
  • M G Raducha
  • D F Patterson
  • U Prociuk
  • B P Engelward
  • J R Testa
  • G Sonoda
  • T Marunouchi
  • N Ogiso
  • D J Bergsma
  • N A Jenkins
  • H Takahashi
  • T Watanabe
  • D H Gilbert
  • N G Copeland
  • G G Rousseau
  • L B Rowe
  • M Hasegawa
  • I Oshima
  • J I Gordon

Detail Information

Publications33

  1. ncbi Glk: a locus controlling galactokinase activity in the mouse
    J D Mishkin
    Biochem Genet 14:635-40. 1976
    Inbred strains of mice exhibited significant variation in whole blood galactokinase (GALK) activity. Activities tend to cluster into two classes, one class having approximately twice the activity of the other...
  2. pmc Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver
    F P Lemaigre
    Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium
    Biochem J 303:1-14. 1994
  3. ncbi The locus controlling pineal serotonin N-acetyltransferase activity (Nat-2) is located on mouse chromosome 11
    M Goto
    Department of Animal Physiology, Faculty of Agriculture, Nagoya University, Japan
    Brain Res Mol Brain Res 21:349-54. 1994
    ..a close linkage on chromosome 11 was found between Nat-2, Es-3 (esterase-3), Glk (the locus controlling galactokinase activity) and Myla (myosin alkali light chains expressed in cardiac atrial muscle)...
  4. ncbi Cloning and characterization of a mouse 3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase cDNA whose gene maps to chromosome 11
    B P Engelward
    Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115
    Carcinogenesis 14:175-81. 1993
    ..Cloning the mouse 3MeA DNA glycosylase cDNA is a step toward understanding the role of this DNA repair enzyme in mammals...
  5. ncbi Mouse galactokinase: isolation, characterization, and location on chromosome 11
    Y Ai
    Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Genome Res 5:53-9. 1995
    Elevated galactose levels can be caused by several enzyme defects, one of which is galactokinase. Galactokinase deficiency cause congenital cataracts during infancy and presenile cataracts in the adult population...
  6. ncbi Genetic mapping of the polycystic kidney gene, pcy, on mouse chromosome 9
    S Nagao
    Laboratory Animal Center, Fujita Health University, Aichi, Japan
    Biochem Genet 33:401-12. 1995
    ..However, no recombinant was observed among pcy, D9Mit14, and D9Mit148. These findings strongly suggest that D9Mit14 and D9Mit148 are located near the pcy gene and are good markers for chromosomal walking to this gene...
  7. ncbi Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene
    D A Altomare
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cytogenet Cell Genet 74:248-51. 1996
    ..The Akt2 pseudogene was mapped to proximal MMU11 by both multilocus mapping and fluorescence in situ hybridization...
  8. ncbi Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5
    P Werner
    Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
    Genomics 42:74-82. 1997
    ..mapped to the centromeric two-thirds of dog chromosome 9 (CFA9), an acrocentric chromosome of medium size: P4HB, GALK1, TK1, GH1, MYL4, BRCA1, RARA, THRA1, MPO, NF1, and CRYBA1...
  9. ncbi Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex
    R M Abdel-Majid
    Department of Anatomy and Neurobiology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Nat Genet 19:289-91. 1998
    ..These results provide the first evidence for involvement of cAMP signalling pathways in pattern formation of the brain...
  10. ncbi A mouse model of galactose-induced cataracts
    Y Ai
    Department of Ophthalmology and Genetics, University of Pennsylvania, Room 313 Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Hum Mol Genet 9:1821-7. 2000
    b>Galactokinase (GK; EC 2.7.1.6) is the first enzyme in the metabolism of galactose. In humans, GK deficiency results in congenital cataracts due to an accumulation of galactitol within the lens...
  11. ncbi The murine atrial myosin light chain-2 gene: a member of an evolutionarily conserved family of contractile proteins
    P A Doevendans
    Department of Cardiology, Academic Hospital Maastricht, The Netherlands
    Cytogenet Cell Genet 90:248-52. 2000
    ..The intron-exon boundaries turned out to be highly conserved and an increasing intron size in more complex mammalian species was found. At the amino acid level there is 95% homology between the human and mouse MLC-2a sequence...
  12. ncbi Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells
    Hidetoshi Kumagai
    Division of Hematopoietic Factors, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 6 1 Shirokanedai 4 chome, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 307:719-29. 2003
    ..These findings suggest that a new pair of ITIM/ITAM-bearing receptors, LMIR1 and 2, regulate mast cell-mediated inflammatory responses through yet to be defined ligand(s)...
  13. ncbi Galactitol and galactonate accumulation in heart and skeletal muscle of mice with deficiency of galactose-1-phosphate uridyltransferase
    Claire Yager
    Metabolic Research Laboratory, The Children s Hospital of Philadelphia, and the Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Genet Metab 81:105-11. 2004
    ..The ability of heart and muscle to form galactonate may also contribute to the G/G mouse's ability to slowly oxidize galactose to CO2, since the compound is an intermediate in an alternate route for galactose disposition...
  14. ncbi Developmental regulation of galactokinase in suckling mouse liver by the Egr-1 transcription factor
    Fang Yang
    Pediatric Endocrine Unit, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA 02114, USA
    Pediatr Res 55:822-9. 2004
    ..In screening the sequences of the genes involved in lactose assimilation, we found that the galactokinase gene Glk contains four potential Egr-1 binding sites in its proximal promoter...
  15. ncbi Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice
    Shigeru Takeshita
    Department of Diabetes, Pharmacology Research Laboratories, Astellas Pharma Inc, Ibaraki, Japan
    Mamm Genome 17:927-40. 2006
    ..Identification of the genes responsible for these QTLs would provide new drug development targets for human T2D...
  16. ncbi Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11
    E H Birkenmeier
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 5:805-6. 1994
  17. pmc Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase
    T Ito
    Johns Hopkins Oncology Center, Baltimore, MD 21231
    Proc Natl Acad Sci U S A 91:7455-9. 1994
    ..Thus, IL-3 appears to positively regulate protein synthesis by inducing the inactivation of PKR in a growth factor signaling pathway...
  18. pmc Evidence for unequal crossing over within the mouse T/t complex
    L M Silver
    Proc Natl Acad Sci U S A 77:6077-80. 1980
    ..This could account for both the suppression of normal recombination along the stretch of t chromatin and the frequent unequal crossing over when rare recombinational events do take place...
  19. ncbi Synteny of the genes for thymidine kinase and galactokinase in the mouse and their assignment to mouse chromosome 11
    P McBreen
    Cytogenet Cell Genet 19:7-13. 1977
    We have studied the expression of mouse galactokinase in human-mouse somatic cell hybrids segregating mouse chromosomes...
  20. ncbi Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids
    C A Kozak
    Somatic Cell Genet 3:121-33. 1977
  21. ncbi Conservation of autosomal gene synteny groups in mouse and man
    P A Lalley
    Nature 274:160-3. 1978
  22. ncbi Linkage of acid alpha-glucosidase (Gaa) and thymidine kinase (Tk-1) to esterase-3 (Es-3) on mouse chromosome 11
    F Martiniuk
    Department of Medicine, New York University Medical Center, New York 10016
    Mamm Genome 1:267-9. 1991
    ..This result extends the region of homology between mouse Chr 11 and human chr 17q...
  23. ncbi A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11
    J H Nadeau
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 5:454-62. 1989
    ....
  24. ncbi Chromosomal and regional localization of the genes for UMPH2, APRT, PEPD, PEPS, PSP, and PGP in mink: comparison with man and mouse
    S D Pack
    Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Department, Novosibirsk
    Cytogenet Cell Genet 50:127-31. 1989
    ..The present data is compared with that previously established for man and mouse with reference to the conservation of syntenic gene groups and G-band homoeologies of chromosomes in mammals...
  25. pmc The Hox-2 homeo box gene complex on mouse chromosome 11 is closely linked to Re
    C P Hart
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Genetics 118:319-27. 1988
    ..The results place the Hoax-2 locus approximately 1 cM from the rex (Re) locus on mouse chromosome 11...
  26. ncbi Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross
    B Robert
    Nature 314:181-3. 1985
    ..No linkage between these genes was observed...
  27. ncbi Provisional assignment of the gene for uridine monophosphatase-2 (Umph-2) to mouse chromosome 11
    D E Wilson
    Biochem Genet 25:1-6. 1987
    ..Umph-2 cosegregated with the mouse galactokinase (Glk) gene in 23 of the 24 hybrids and showed at least four discordances with all other mouse marker isozymes ..
  28. ncbi The physical map of Mus musculus chromosome 11 reveals evolutionary relationships with different syntenic groups of genes in Homo sapiens
    M M√ľnke
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    J Mol Evol 25:134-40. 1987
    ..The delineation of conserved chromosome regions has important implications for the understanding of karyotype evolution in mammalian species and for the development of animal models of human genetic diseases...
  29. pmc Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man
    B U Zabel
    Proc Natl Acad Sci U S A 81:4874-8. 1984
    ..We found c-erb-A sequences on human chromosome 17 (17p11----qter) and located c-erb-B on human chromosome 7 (7pter----q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11...
  30. ncbi The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21 to qter
    D L George
    Hum Genet 57:138-41. 1981
    ..Analysis of mouse x human hybrid cells containing only part of the long arm of chromosome 17 enabled us to localize these genes to region 17q21 to 17qter...
  31. pmc Characterization of a recombinant mouse T haplotype that expresses a dominant lethal maternal effect
    H Winking
    Genetics 108:1013-20. 1984
    ..The results presented here allow a mapping of the Tme locus between the quaking and tufted loci which are 3 cM apart within the proximal region of chromosome 17...
  32. ncbi Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome
    L A Leinwand
    Science 221:766-9. 1983
    ..A synteny between myosin heavy chain and two unrelated markers, thymidine kinase and galactokinase, was found to be preserved in the rodent and human genomes.
  33. doi Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine
    Minoru Tomizawa
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba, 260 8670, Japan
    Cell Tissue Res 333:17-27. 2008
    ..Since only hepatocytes have the activity of ornithine transcarbamylase, phenylalanine hydroxylase, galactokinase, and glycerol kinase, we expected that hepatocytes would be enriched in a medium without arginine, tyrosine, ..