Gadd45b

Summary

Gene Symbol: Gadd45b
Description: growth arrest and DNA-damage-inducible 45 beta
Alias: AI323528, Myd118, growth arrest and DNA damage-inducible protein GADD45 beta, myeloid differentiation primary response gene 118, myeloid differentiation primary response protein MyD118, negative growth regulatory protein MyD118
Species: mouse

Top Publications

  1. ncbi Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2
    Salvatore Papa
    The Gwen Knapp Center for Lupus and Immunology Research, and The Ben May Institute for Cancer Research, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    Nat Cell Biol 6:146-53. 2004
  2. pmc Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Science 323:1074-7. 2009
  3. doi Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development
    Lilian T Kaufmann
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Gene Expr Patterns 11:465-70. 2011
  4. ncbi Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia
    Amedeo Columbano
    Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Italy
    Hepatology 42:1118-26. 2005
  5. ncbi Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis
    Mamta Gupta
    Fels Institute of Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Oncogene 24:7170-9. 2005
  6. ncbi Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells
    Qi Cai
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 291:F341-9. 2006
  7. pmc Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling
    Salvatore Papa
    Ben May Department for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 118:1911-23. 2008
  8. ncbi CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle
    Hyo Kyun Chung
    Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Chungnam National University School of Medicine, Daejeon 301 721 Korea
    J Biol Chem 278:28079-88. 2003
  9. ncbi GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress
    Mariappan Vairapandi
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Physiol 192:327-38. 2002
  10. ncbi Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines
    A Abdollahi
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104
    Oncogene 6:165-7. 1991

Scientific Experts

  • Eiji Matsunaga
  • Akio Morinobu
  • Amedeo Columbano
  • Dengke K Ma
  • Bin Liu
  • Ning Zhang
  • Dan A Liebermann
  • Barbara Hoffman
  • Binfeng Lu
  • Salvatore Papa
  • Guido Franzoso
  • Yukio Yamamoto
  • Kosei Ijiri
  • Lin Liu
  • Richard A Flavell
  • Mamta Gupta
  • Kaneyuki Tsuchimochi
  • D A Liebermann
  • B Hoffman
  • Setsuro Komiya
  • Mary B Goldring
  • David P Gavin
  • Hye Yeon Park
  • Heechul Jun
  • Jung Hwan Kim
  • Jae Ho Lee
  • E Keil
  • Heiko Johnen
  • Jiyun Yoo
  • Dominic M Salerno
  • Qi Cai
  • Albert J Fornace
  • Faraz A Sultan
  • Prescott T Leach
  • Francesca Zazzeroni
  • Jianmin Tian
  • Lilian T Kaufmann
  • Yubin Luo
  • Qianting Yang
  • Hirofumi Shimada
  • Volodymyr P Tryndyak
  • Hee Jun Cho
  • Deepa Hammaker
  • Yuki Okada
  • Gary S Firestein
  • Arthur G Balliet
  • Yibei Zhu
  • Elizabeth Chen
  • David L Boyle
  • Xueguang Zhang
  • Jesus M Salvador
  • Songguang Ju
  • Camilla I Svensson
  • Masahiko Negishi
  • A Engelmann
  • Luiz F Zerbini
  • Towia A Libermann
  • Mari Iida
  • Akanksha Mittal
  • Kellean Alvarez
  • Concetta Bubici
  • Li Wang
  • A G Balliet
  • S K Gupta
  • Yani Zhao
  • Akinobu Okada
  • Hongbo Chi
  • Sally K Mak
  • Maurice B Burg
  • Joan D Ferraris
  • Huaibo Zhang
  • Yong Hoon Kim
  • Chul Ho Lee
  • Jun Go
  • Arshad Amanullah
  • Handojo Kusumo
  • Tae Shin Park
  • Jung Hwan Hwang
  • Alessandro Guidotti
  • Hyo Kyun Chung
  • Subhash C Pandey
  • Kyoung Shim Kim
  • Myungchull Rhee
  • Dung U Nguyen
  • Dietmar Kültz
  • Young Kyoung Ryu
  • Enrico De Smaele
  • Dong Hee Choi
  • Syed Mohammed Qasim Hussaini
  • Chang Hoon Cho

Detail Information

Publications56

  1. ncbi Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2
    Salvatore Papa
    The Gwen Knapp Center for Lupus and Immunology Research, and The Ben May Institute for Cancer Research, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    Nat Cell Biol 6:146-53. 2004
    ..Using an unbiased screen, we have previously identified Gadd45 beta/Myd118, a member of the Gadd45 family of inducible factors, as a pivotal mediator of this suppressive activity of NF-..
  2. pmc Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Science 323:1074-7. 2009
    ..Here we identify Gadd45b as a neural activity-induced immediate early gene in mature hippocampal neurons...
  3. doi Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development
    Lilian T Kaufmann
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Gene Expr Patterns 11:465-70. 2011
    ..Here we provide a comprehensive comparison of Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development...
  4. ncbi Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia
    Amedeo Columbano
    Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Italy
    Hepatology 42:1118-26. 2005
    We previously observed that Gadd45/MyD118, a member of the Gadd45 family of inducible factors, showed the strongest immediate-early induction common to two distinctive proliferation responses of the liver: (1) regeneration induced by ..
  5. ncbi Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis
    Mamta Gupta
    Fels Institute of Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Oncogene 24:7170-9. 2005
    Gadd45a, gadd45b and gadd45g (Gadd45/MyD118/CR6) are genes that are rapidly induced by genotoxic stress. However, the exact function of Gadd45 proteins in the response of mammalian cells to genotoxic stress is unclear...
  6. ncbi Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells
    Qi Cai
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 291:F341-9. 2006
    ..Acutely elevating NaCl (and/or urea) reduces Gadd45a, but increases Gadd45b and Gadd45g mRNA, depending on the mix of NaCl and urea and the rate of increase of osmolality...
  7. pmc Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling
    Salvatore Papa
    Ben May Department for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 118:1911-23. 2008
    ..The basis for this modulation, however, is unknown. Here, we investigated the role of the NF-kappaB target Gadd45b in the regulation of hepatocyte fate during liver regeneration after partial hepatectomy...
  8. ncbi CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle
    Hyo Kyun Chung
    Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Chungnam National University School of Medicine, Daejeon 301 721 Korea
    J Biol Chem 278:28079-88. 2003
    The Gadd45 family of proteins includes Gadd45alpha, MyD118/Gadd45beta, and CR6/OIG37/Gadd45gamma. These proteins play important roles in maintaining genomic stability and in regulating the cell cycle...
  9. ncbi GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress
    Mariappan Vairapandi
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Physiol 192:327-38. 2002
    Gadd45a (Gadd45), Gadd45b (MyD118), and Gadd45g (CR6) constitute a family of evolutionarily conserved, small, acidic, nuclear proteins, which have been implicated in terminal differentiation, growth suppression, and apoptosis...
  10. ncbi Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines
    A Abdollahi
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104
    Oncogene 6:165-7. 1991
    We report here the full length cDNA sequence and the deduced amino acid sequence of MyD118, a novel myeloid differentiation primary response gene transiently expressed in M1D+ myeloid precursors following induction of terminal ..
  11. ncbi Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells
    Binfeng Lu
    Section of Immunobiology, Yale University School of Medicine, 310 Cedar Street, New Haven, Connecticut 06520 8011, USA
    Nat Immunol 5:38-44. 2004
    ..In T cells, Gadd45b was rapidly induced by T cell receptor (TCR) and inflammatory signals...
  12. pmc Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3
    Jung Hwan Kim
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Hepatology 59:695-704. 2014
    Growth arrest and DNA damage-inducible beta (GADD45b) plays an important role in many intracellular events, such as cell cycle arrest, DNA repair, cell survival, apoptosis, and senescence...
  13. pmc Gadd45g is essential for primary sex determination, male fertility and testis development
    Heiko Johnen
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Cantoblanco, Madrid, Spain
    PLoS ONE 8:e58751. 2013
    ..We characterized mice deficient in Gadd45a, Gadd45b and Gadd45g, as well as double-knockout mice for Gadd45ab, Gadd45ag and Gadd45bg, and found a specific role for ..
  14. pmc Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation
    Jae Ho Lee
    School of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
    Hepatology 60:844-57. 2014
    ..Here, we reveal that RNF20-induced SREBP1c ubiquitination down-regulates hepatic lipogenic activity upon PKA activation...
  15. doi Comparative analysis of developmentally regulated expressions of Gadd45a, Gadd45b, and Gadd45g in the mouse and marmoset cerebral cortex
    E Matsunaga
    Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, Hirosawa 2 1, Wako 351 0198, Japan Electronic address
    Neuroscience 284:566-80. 2015
    ..Thus, these results suggest the possibility that differential Gadd45 expression affects neurons, contributing cortical evolution and diversity. ..
  16. pmc Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy
    E Keil
    Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, Universitatsstr 1, Dusseldorf, Germany
    Cell Death Differ 20:321-32. 2013
    ..Thus, we show for the first time that Atg5 activity is controlled by phosphorylation and, moreover, that the spatial regulation of p38 by Gadd45β/MEKK4 negatively regulates the autophagic process...
  17. pmc Gadd45b Mediates Electroconvulsive Shock Induced Proliferation of Hippocampal Neural Stem Cells
    Heechul Jun
    Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA
    Brain Stimul 8:1021-4. 2015
    ..Previous research in animal models suggests ECS efficacy is achieved by Gadd45b-mediated increases in adult hippocampal neurogenesis.
  18. pmc Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors
    David P Gavin
    Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois
    Alcohol Clin Exp Res 40:263-72. 2016
    ..b>GADD45b is a protein demonstrated to be involved in DNA demethylation at neurotrophic factor gene promoters, including at ..
  19. doi Gadd45β ameliorates L-DOPA-induced dyskinesia in a Parkinson's disease mouse model
    Hye Yeon Park
    Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon 34141, Republic of Korea
    Neurobiol Dis 89:169-79. 2016
    ..These data suggest that the increased expression of Gadd45β induced by repeated administration of L-DOPA may be beneficial in patients with PD...
  20. doi Gadd45a and Gadd45b modulate innate immune functions of granulocytes and macrophages by differential regulation of p38 and JNK signaling
    Dominic M Salerno
    Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Cell Physiol 227:3613-20. 2012
    ..This study shows that mice lacking either Gadd45a or Gadd45b are defective in the recruitment of granulocytes and macrophages to the intra-peritoneal cavity following intra-..
  21. pmc Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice
    Yubin Luo
    University of California, San Diego at La Jolla
    Arthritis Rheum 63:2949-55. 2011
    ..To further understand how GADD45β regulates autoimmunity, we evaluated collagen-induced arthritis in GADD45β-/- mice...
  22. pmc IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells
    Qianting Yang
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Eur J Immunol 41:3351-60. 2011
    ..The synergistic effect of IL-33 and IL-12 is partly mediated by Gadd45b. Together, these in vitro data establish a novel role of IL-33 in promoting effector type 1 adaptive immune ..
  23. pmc Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory
    Prescott T Leach
    Department of Psychology, Neuroscience Program, Temple University, Philadelphia, Pennsylvania 19122, USA
    Learn Mem 19:319-24. 2012
    Growth arrest and DNA damage-inducible β (Gadd45b) has been shown to be involved in DNA demethylation and may be important for cognitive processes...
  24. pmc Genetic deletion of Gadd45b, a regulator of active DNA demethylation, enhances long-term memory and synaptic plasticity
    Faraz A Sultan
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 32:17059-66. 2012
    ..New discoveries aim toward the Growth arrest and DNA damage-inducible 45 (Gadd45) family, particularly Gadd45b, in activity-dependent demethylation in the adult CNS...
  25. pmc TGFβ signaling induces expression of Gadd45b in retinal ganglion cells
    Bin Liu
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Hospitals and Health Sciences System, 1855 West Taylor Street, MC 648, Chicago, IL 60612, USA
    Invest Ophthalmol Vis Sci 54:1061-9. 2013
    Growth arrest and DNA damage protein 45b (Gadd45b) functions as an intrinsic neuroprotective molecule protecting retinal ganglion cells (RGCs) from injury...
  26. pmc Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice
    Jianmin Tian
    Department of Pathology and Marion Bessin Liver Center, Albert Einstein College of Medicine, New York, New York, USA
    J Clin Invest 121:4491-502. 2011
    The growth arrest and DNA damage-inducible 45 (Gadd45) proteins act in many cellular processes. In the liver, Gadd45b (encoding Gadd45β) is the gene most strongly induced early during both compensatory regeneration and drug-induced ..
  27. pmc The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription
    Yukio Yamamoto
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Drug Metab Dispos 36:1189-93. 2008
    ..receptor (CAR) up-regulated expression of the apoptotic growth arrest and DNA-damage-inducible 45 beta (GADD45B) gene in HepG2 cells...
  28. pmc Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice
    Hirofumi Shimada
    Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima, 890 8520, Japan
    Pathol Res Pract 207:225-31. 2011
    ..Co-expression of C/EBPβ and p21 was confirmed. These observations suggest that the synergism between GADD45β and C/EBPβ may play an important role in cellular senescence in the aging articular cartilage...
  29. doi Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mol Nutr Food Res 55:411-8. 2011
    ..However, whether methyl deficiency affects the methylation status of gene promoters has not been explored...
  30. pmc Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor
    Hee Jun Cho
    Department of Microbiology Research Institute of Life Science, College of Natural Sciences, Gyeongsang National University, Jinju 660 701, Korea
    J Biol Chem 285:25500-5. 2010
    b>Gadd45b has been known as a positive mediator of apoptosis induced by certain cytokines and oncogenes...
  31. pmc Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B
    Yukio Yamamoto
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 5:e10121. 2010
    ..Here we have identified Growth Arrest and DNA Damage-inducible 45beta (GADD45B) as a novel CAR target, through which CAR represses cell death.
  32. pmc A role for the elongator complex in zygotic paternal genome demethylation
    Yuki Okada
    Howard Hughes Medical Institute, Chapel Hill, North Carolina 27599 7295, USA
    Nature 463:554-8. 2010
    ....
  33. pmc GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes
    Kaneyuki Tsuchimochi
    Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York, New York 10021, USA
    J Biol Chem 285:8395-407. 2010
    ..Collectively, we have uncovered a novel molecular mechanism linking GADD45beta via the MTK1/MKK3/6/p38 axis to C/EBPbeta-TAD4 activation of Col10a1 transcription in terminally differentiating chondrocytes...
  34. ncbi Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice
    Akinobu Okada
    Drug Safety Research Laboratories, Astellas Pharma Inc, 2 1 6 Kashima, Yodogawa ku, Osaka 532 8514, Japan
    Birth Defects Res A Clin Mol Teratol 73:229-38. 2005
    ..However, the molecular mechanism of its teratogenesis is unknown. This study was conducted to investigate the genomewide effects of VPA disruption of normal neural tube development in mice...
  35. ncbi Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control
    M Vairapandi
    Fels Institute for Cancer Research and Molecular Biology and the Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 275:16810-9. 2000
    b>MyD118 and Gadd45 are related genes encoding for proteins that play important roles in negative growth control, including growth suppression and apoptosis...
  36. ncbi Gadd45 family proteins are coactivators of nuclear hormone receptors
    Y W Yi
    Therapeutic Gene Group, Samyang Genex Biotech Research Institute, Taejeon, Korea
    Biochem Biophys Res Commun 272:193-8. 2000
    Gadd45 family genes encode nuclear acidic proteins composed of Gadd45, MyD118, and CR6...
  37. ncbi Comparative analysis of the genetic structure and chromosomal location of the murine MyD118 (Gadd45beta) gene
    A G Balliet
    Fels Institute for Cancer Research and Molecular Biology and the Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    DNA Cell Biol 20:239-47. 2001
    The MyD118 (Gadd45beta) protein is a member of a family of structurally related proteins, including Gadd45 (Gadd45alpha) and CR6 (Gadd45gamma), that have critical roles in regulating growth arrest and apoptosis...
  38. ncbi Regulation of the gadd45beta promoter by NF-kappaB
    Rongguan Jin
    The Gwen Knapp Center for Lupus and Immunology Research, and The Ben May Institute for Cancer Research, Committees on Immunology and Cancer Biology, The University of Chicago, Chicago, Illinois 60637, USA
    DNA Cell Biol 21:491-503. 2002
    ..is a pivotal protective mechanism by NF-kappaB, and that this suppression involves the upregulation of gadd45beta/myd118. Induction of gadd45beta by stress and cytokines requires NF-kappaB; however, the regulatory mechanisms underlying ..
  39. pmc STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation
    Akio Morinobu
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:12281-6. 2002
    ..We conclude that phosphorylation of STAT4 on both tyrosine and serine residues is important in promoting normal T(H)1 differentiation and IFN-gamma secretion...
  40. ncbi Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells
    Devulapalli Chakravarty
    The Whitney Laboratory, University of Florida, St Augustine, Florida 32080, USA
    Am J Physiol Renal Physiol 283:F1020-9. 2002
    ..These data associate all known GADD45 isoforms with the hypertonicity phenotype of renal IM cells...
  41. ncbi Cell signalling: cell survival and a Gadd45-factor deficiency
    Arshad Amanullah
    Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Nature 424:741; discussion 742. 2003
  42. ncbi Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation
    Jiyun Yoo
    Laboratory of Cell Regulation and Carcinogenesis, National Instituts of Health, Bethesda, MD 20892 5055, USA
    J Biol Chem 278:43001-7. 2003
    ..In this report, we identify GADD45b as an effector of TGF-beta-induced apoptosis...
  43. pmc GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells
    Hongbo Chi
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
    EMBO J 23:1576-86. 2004
    ..During Th1 differentiation, the GADD45beta/GADD45gamma/MEKK4 pathway appears to integrate upstream signals transduced by both T cell receptor and IL12/STAT4, leading to augmented IFNgamma production in a process independent of STAT4...
  44. ncbi Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress
    Sally K Mak
    Physiological Genomics Group, Department of Animal Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 279:39075-84. 2004
    ....
  45. ncbi NF-kappaB and not the MAPK signaling pathway regulates GADD45beta expression during acute inflammation
    Ning Zhang
    Xenogen Corporation, Alameda, California 94501, USA
    J Biol Chem 280:21400-8. 2005
    ..Thus, NF-kappaB signaling involves induction of GADD45beta expression, which supports the proposed role of GADD45beta in protecting cells against DNA damaged under various stress conditions...
  46. pmc Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling
    Camilla I Svensson
    University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Arthritis Rheum 60:3229-40. 2009
    ..This study was carried out to evaluate whether low Gadd45beta expression in RA enhances JNK activation and overproduction of MMPs in RA, and whether Gadd45beta deficiency increases arthritis severity in passive K/BxN murine arthritis...
  47. pmc A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation
    Kosei Ijiri
    Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:38544-55. 2005
    ..These observations indicated that GADD45beta plays an essential role during chondrocyte terminal differentiation...
  48. pmc Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity
    Lin Liu
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Exp Med 202:1341-7. 2005
    ..Our findings therefore identify the Gadd45beta/Gadd45gamma-mediated control of effector autoimmune lymphocytes as an attractive novel target for autoimmune disease therapy...
  49. ncbi NF-kappaB-dependent regulation of the timing of activation-induced cell death of T lymphocytes
    Akanksha Mittal
    Rosensteil Research Center and Department of Biology, Brandeis University, Waltham, MA 02454, USA
    J Immunol 176:2183-9. 2006
    ..We propose that the timing of AICD, and thus the length of the effector phase, are regulated by transient expression of a subset of p65/RelA-dependent antiapoptotic genes...
  50. ncbi Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition
    Mamta Gupta
    Fels Institute of Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, 3307 N Broad Street, Philadelphia, PA 19140, USA
    J Biol Chem 281:17552-8. 2006
    Gadd45a, Gadd45b, and Gadd45g (Gadd45/MyD118/CR6) are genes that are rapidly induced by genotoxic stress and have been implicated in genotoxic stress-induced responses, notably in apoptosis...
  51. ncbi Hematopoietic cells from gadd45a-deficient and gadd45b-deficient mice exhibit impaired stress responses to acute stimulation with cytokines, myeloablation and inflammation
    S K Gupta
    Department of Biochemistry, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19104, USA
    Oncogene 25:5537-46. 2006
    ..Using bone marrow (BM) from gadd45a-/-, gadd45b-/- and wild-type (wt) mice, we investigated their role in stress responses of myeloid cells to acute stimulation ..
  52. ncbi Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45beta
    Li Wang
    Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cell Res 16:702-12. 2006
    ..are responsible for the higher proliferation and resistance to AICD, the expression of Fas/Fas ligand (FasL) and GADD45b was measured by real-time PCR...
  53. ncbi The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b
    Mari Iida
    Laboratory of Molecular Carcinogenesis, Toxicology Operations Branch, Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
    Toxicol Sci 99:43-50. 2007
    ..We selected two potential transcriptional targets of Tsc-22, growth arrest and DNA damage-inducible gene 45 beta (Gadd45b) and leucine zipper, putative tumor suppressor 2 (Lzts2) to test based on our previous complementary DNA ..
  54. ncbi Gadd45 beta is a pro-survival factor associated with stress-resistant tumors
    A Engelmann
    Heinrich Pette Institut, Hamburg, Germany
    Oncogene 27:1429-38. 2008
    ..In addition to the gene encoding the antiapoptotic Bcl-x(L) protein, we identified the gadd45b locus to be a novel common integration site in these tumors, leading to enhanced expression...
  55. pmc Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries
    Bin Liu
    Department of Ophthalmology, Northwestern University School of Medicine, Chicago, IL 60611, USA
    Neurobiol Dis 33:104-10. 2009
    ..In the present study, we find that growth arrest and DNA damage protein 45b (Gadd45b), a previously unknown molecule in neurons of any type, is neuroprotective in retinal ganglion cells (RGCs) in ..
  56. pmc Gadd45b and Gadd45g are important for anti-tumor immune responses
    Songguang Ju
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Eur J Immunol 39:3010-8. 2009
    ..b>Gadd45b, a signaling molecule highly up-regulated during Th1 type responses, is studied for its role in limiting tumor ..