Gad1

Summary

Gene Symbol: Gad1
Description: glutamate decarboxylase 1
Alias: EP10, Gad-1, glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, glutamate decarboxylase 67 kDa isoform, glutamic acid decarboxylase 1
Species: mouse

Top Publications

  1. pmc A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors
    Minoree Kohwi
    Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:6878-91. 2007
  2. doi Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome
    Eva K Wirth
    Neuroscience Research Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neurosci 29:9439-49. 2009
  3. pmc GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 54:889-903. 2007
  4. pmc Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain
    Luis R Hernández-Miranda
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 31:6174-87. 2011
  5. pmc Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells
    Hitoshi Kawaguchi
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Biol Chem 285:17277-81. 2010
  6. pmc Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons
    Annie K Ting
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 31:15-25. 2011
  7. pmc A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    C Fode
    Institut de G en etique et de Biologie Mol eculaire et Cellulaire, Centre National de la Recherche Scient ifique Institut National de la Sant e et de la Recherche M edicale, Communaut e Urbaine de Strasbourg, France
    Genes Dev 14:67-80. 2000
  8. doi Distinct requirements for Ascl1 in subpopulations of midbrain GABAergic neurons
    Paula Peltopuro
    Institute of Biotechnology, P O Box 56, Viikinkaari 9, FIN00014 University of Helsinki, Helsinki, Finland
    Dev Biol 343:63-70. 2010
  9. pmc Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory
    Ruby Nagata-Kuroiwa
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    PLoS ONE 6:e16972. 2011
  10. ncbi Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets
    J Kim
    Department of Medicine, University of California at San Francisco 94143 0534
    Diabetes 42:1799-808. 1993

Research Grants

Scientific Experts

Detail Information

Publications139 found, 100 shown here

  1. pmc A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors
    Minoree Kohwi
    Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:6878-91. 2007
    ..Our results suggest that some OB interneurons are derived from progenitors outside the LGE and that precursors expressing what has classically been considered a pallial transcription factor generate GABAergic interneurons...
  2. doi Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome
    Eva K Wirth
    Neuroscience Research Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neurosci 29:9439-49. 2009
    ....
  3. pmc GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 54:889-903. 2007
    ..Since intracellular GABA levels are modulated by neuronal activity, our results implicate GAD67-mediated GABA synthesis in activity-dependent regulation of inhibitory innervation patterns...
  4. pmc Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain
    Luis R Hernández-Miranda
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 31:6174-87. 2011
    ..Thus, we show for the first time that Robo1 interacts with Nrp1 to modulate semaphorin signaling in the developing forebrain and direct the migration of interneurons through the subpallium and into the cortex...
  5. pmc Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells
    Hitoshi Kawaguchi
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Biol Chem 285:17277-81. 2010
    ..Thus, PKD2L1-PKD1L3-mediated acid-evoked off responses occurred both in HEK293 cells and in native taste cells, suggesting the involvement of the PKD2L1-PKD1L3 complex in acid sensing in vivo...
  6. pmc Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons
    Annie K Ting
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 31:15-25. 2011
    ..In light of the association of the genes of both NRG1 and ErbB4 with schizophrenia and dysfunction of GABAergic system in this disorder, these results provide insight into its potential pathological mechanism...
  7. pmc A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    C Fode
    Institut de G en etique et de Biologie Mol eculaire et Cellulaire, Centre National de la Recherche Scient ifique Institut National de la Sant e et de la Recherche M edicale, Communaut e Urbaine de Strasbourg, France
    Genes Dev 14:67-80. 2000
    ....
  8. doi Distinct requirements for Ascl1 in subpopulations of midbrain GABAergic neurons
    Paula Peltopuro
    Institute of Biotechnology, P O Box 56, Viikinkaari 9, FIN00014 University of Helsinki, Helsinki, Finland
    Dev Biol 343:63-70. 2010
    ..Also, our results have implications on understanding the origins of the various midbrain GABAergic neuron groups in the embryonic neuroepithelium...
  9. pmc Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory
    Ruby Nagata-Kuroiwa
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    PLoS ONE 6:e16972. 2011
    ..These findings suggest important roles of NPBWR1 in regulating amygdala function during physical and social stress...
  10. ncbi Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets
    J Kim
    Department of Medicine, University of California at San Francisco 94143 0534
    Diabetes 42:1799-808. 1993
    ....
  11. pmc Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor
    Bing Xing Pan
    Unit on Behavioral Genetics, Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Neuron 61:917-29. 2009
    ..Thus, target-cell-specific control of glutamate release by presynaptic GABAbR orchestrates the inhibitory dominance inside amygdala and might contribute to prevention of nonadaptive defensive behaviors...
  12. doi Differential gene expression in migrating cortical interneurons during mouse forebrain development
    Clare Faux
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Comp Neurol 518:1232-48. 2010
    ..These data therefore provide a framework for future studies aimed at elucidating the complexities of interneuron migration and, in turn, may reveal important genes that are related to the development of specific neurological disorders...
  13. ncbi Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning
    Joshua G Corbin
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Development 130:4895-906. 2003
    ..1 dependent specification of oligodendrocytes. Therefore, both integrative and antagonistic interactions between homeodomain-containing transcription factors contribute to the patterning of the telencephalon...
  14. ncbi Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
    Nat Neurosci 8:1059-68. 2005
    ..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss...
  15. pmc Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons
    Alessandro Sessa
    Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy
    Genes Dev 24:1816-26. 2010
    ..We thus propose that INPs are able to control simultaneously the increase of glutamatergic and GABAergic neuronal pools, thereby creating a simple way to intrinsically balance their relative accumulation...
  16. pmc Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia
    Allison A Curley
    Department of Psychiatry, W1653 Biomedical Science Tower, 200 Lothrop St University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurobiol Dis 50:179-86. 2013
    ..Together, these findings suggest that the correlated decrements in cortical GAD67, PV and GAT1 mRNAs in schizophrenia may be a common consequence of some other upstream factor...
  17. doi Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate
    Juan Antonio Moreno-Bravo
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas, and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Dev Dyn 239:2094-101. 2010
    ..The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei...
  18. ncbi Disruption of the gene encoding SF-1 alters the distribution of hypothalamic neuronal phenotypes
    T L Dellovade
    Department of Biomedical Sciences, The Eunice Kennedy Shriver Center, Program in Neuroscience, Harvard Medical School, Waltham, Massachusetts 02452, USA
    J Comp Neurol 423:579-89. 2000
    ..These data suggest that, directly or indirectly, SF-1 plays important roles in determining the distribution of cells in the mediobasal hypothalamus...
  19. pmc Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
    Yoshinobu Sugitani
    Department of Cell Biology, JFCR Cancer Institute, Tokyo 170 8455, Japan
    Genes Dev 16:1760-5. 2002
    ..These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development...
  20. ncbi The adhesion molecule TAG-1 is required for proper migration of the superficial migratory stream in the medulla but not of cortical interneurons
    Myrto Denaxa
    University of Crete Medical School, Heraklion 71110, Crete, Greece
    Dev Biol 288:87-99. 2005
    ..Therefore, TAG-1 function is required for the survival of the neurons of some precerebellar nuclei, while it is not required for cortical interneuron migration in vivo...
  21. pmc Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons
    R Satta
    Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 105:16356-61. 2008
    ..Nicotine is not effective in striatal medium spiny GABAergic neurons that primarily express muscarinic receptors...
  22. pmc Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
    Gina M Leinninger
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 10:89-98. 2009
    ..Thus, these findings reveal that LHA LepRb neurons link anorexic leptin action to the mesolimbic DA system...
  23. ncbi Multimodal tangential migration of neocortical GABAergic neurons independent of GPI-anchored proteins
    Daisuke Tanaka
    Graduate School of Frontier Biosciences, Osaka University, Machikaneyama 1 3, Toyonaka, Osaka 560 8531, Japan
    Development 130:5803-13. 2003
    ..At least a part of these neurons may descend toward the CP. Our results also suggest that intracortical migration of GABAergic neurons occurs independent of GPI-anchored proteins...
  24. pmc Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate
    Todd T Kroll
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:7374-9. 2005
    ..Thus, Pax6 delimits the appropriate proliferative zone for GABA INs and regulates their numbers and distributions by repressing the ventral fates of dTel progenitors and progeny...
  25. ncbi Expression of coiled-coil protein 1, a novel gene downstream of FGF2, in the developing brain
    Francesca Pellicano
    Beatson Laboratories for Cancer Research, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Gene Expr Patterns 6:285-93. 2006
    ..We observed that the expressed ccp1 protein was localised to endo/lysosomal compartment in the cell body as well as to vesicles present in the processes of primary cortical neurons and oligodendrocyte cell line...
  26. pmc Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits
    Carrie L Heusner
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genesis 46:357-67. 2008
    ..We generated mice carrying a conditional allele of the Gad1 gene, which encodes GAD67, one of the two enzymes responsible for GABA biosynthesis, and bred them to mice ..
  27. pmc Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice
    Cindy L Yee
    Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, Genetics and Development, San Francisco, California 94158 2611, USA
    J Comp Neurol 517:37-50. 2009
    ..These results have implications for the genetic control of arcuate development and function and for the utility of the Nkx2.1-Cre and Dlx5/6i-Cre mouse lines to alter gene expression in the developing arcuate...
  28. ncbi An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons
    A Bulfone
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Neuron 21:1273-82. 1998
    ..These observations suggest that the establishment of a topographic map is not dependent upon cues provided by, or synapse formation with, the major neuronal cell types in the olfactory bulb...
  29. ncbi Domain-restricted expression of two glutamic acid decarboxylase genes in midgestation mouse embryos
    Z Katarova
    BRC, Institute of Biochemistry, 6701 Szeged, Hungary
    J Comp Neurol 424:607-27. 2000
    ..This pattern of expression is consistent with the notion that GAD and its product, GABA, play a signaling role during development...
  30. ncbi The Gsh2 homeodomain gene controls multiple aspects of telencephalic development
    J G Corbin
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 127:5007-20. 2000
    ..Taken together, our data support a model in which Gsh2, in response to sonic hedgehog signaling, plays a crucial role in multiple aspects of telencephalic development...
  31. ncbi Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon
    K Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, Box 0984, San Francisco, CA 94143 0984, USA
    Development 128:193-205. 2001
    ..The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system...
  32. pmc Distinct protein forms are produced from alternatively spliced bicistronic glutamic acid decarboxylase mRNAs during development
    G Szabo
    Institute of Biochemistry, Biological Research Center, Szeged, Hungary
    Mol Cell Biol 14:7535-45. 1994
    ..The two GAD embryonic forms represent distinct functional domains and display characteristic developmental patterns, consistent with a possible role in the formation of the gamma-aminobutyric acid-ergic inhibitory synapses...
  33. ncbi Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures
    H Asada
    Laboratory of Neurochemistry, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, 444, Japan
    Biochem Biophys Res Commun 229:891-5. 1996
    ....
  34. ncbi Embryonic and postnatal expression of four gamma-aminobutyric acid transporter mRNAs in the mouse brain and leptomeninges
    J E Evans
    Department of Pharmacology, Ohio State University, Columbus 43210, USA
    J Comp Neurol 376:431-46. 1996
    ....
  35. ncbi Structure and the promoter region of the mouse gene encoding the 67-kD form of glutamic acid decarboxylase
    G Szabo
    Institute of Biochemistry, Biological Research Center, Szeged, Hungary
    DNA Cell Biol 15:1081-91. 1996
    ....
  36. pmc Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase
    H Asada
    Laboratory of Neurochemistry, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444, Japan
    Proc Natl Acad Sci U S A 94:6496-9. 1997
    ..Previous pharmacological and genetic investigations have suggested the involvement of GABA in palate formation, but this is the first demonstration of a role for GAD67-derived GABA in the development of nonneural tissue...
  37. ncbi Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons
    S A Anderson
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143, USA
    Neuron 19:27-37. 1997
    ..Several lines of evidence suggest that mutations in Dlx-1 and Dlx-2 produce abnormalities in the development of the striatal subventricular zone and in the differentiation of striatal matrix neurons...
  38. pmc Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67
    B G Condie
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 94:11451-5. 1997
    ..The striking similarity in phenotype between the receptor and ligand mutations clearly demonstrates a role for GABA signaling in normal palate development...
  39. ncbi Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse
    S Alcantara
    Department of Animal and Plant Cell Biology, Faculty of Biology, University of Barcelona, Barcelona 08028, Spain
    J Neurosci 18:7779-99. 1998
    ..This complex pattern of cellular and regional expression is consistent with Reelin having multiple roles in brain development and adult brain function...
  40. ncbi Mash1 regulates neurogenesis in the ventral telencephalon
    S Casarosa
    IGBMC, CNRS INSERM Universite Louis Pasteur, BP 163, CU de Strasbourg, France
    Development 126:525-34. 1999
    ..Therefore, Mash1 is an important regulator of neurogenesis in the ventral telencephalon, where it is required both to specify neuronal precursors and to control the timing of their production...
  41. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
    ..We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage...
  42. ncbi Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice
    S F Kash
    Department of Medicine, and Hormone Research Institute, University of California San Francisco, 94143 0534, USA
    Horm Metab Res 31:340-4. 1999
    ..The results suggest that GABA generated by either GAD65 or GAD67 is not critically involved in islet formation and that GAD65 expression is not an absolute requirement for development of autoimmune diabetes in the NOD mouse...
  43. ncbi The GABA paradox: multiple roles as metabolite, neurotransmitter, and neurodifferentiative agent
    H S Waagepetersen
    PharmaBiotec Research Center, Department of Pharmacology, Royal Danish School of Pharmacy, Copenhagen
    J Neurochem 73:1335-42. 1999
    ..These aspects are discussed in relation to the different functional roles of GABA and its prominent involvement in epileptogenic activity...
  44. ncbi Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons
    S J Pleasure
    Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143, USA
    Neuron 28:727-40. 2000
    ..Loss of hippocampal interneurons does not appear to have major effects on the early development of hippocampal projection neurons nor on the pathfinding of afferrent tracts...
  45. pmc Dynamic expression of a glutamate decarboxylase gene in multiple non-neural tissues during mouse development
    D M Maddox
    Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, USA
    BMC Dev Biol 1:1. 2001
    ..Mouse embryos lacking the 67-kDa isoform of GAD (encoded by the Gad1 gene) develop a complete cleft of the secondary palate...
  46. ncbi Neuronal development of embryonic stem cells: a model of GABAergic neuron differentiation
    J J Westmoreland
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Biochem Biophys Res Commun 284:674-80. 2001
    ..The glutamate decarboxylase genes (Gad1 and Gad2), required for GABA synthesis and the vesicular inhibitory amino acid transporter (Viaat) gene, required ..
  47. ncbi A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice
    H Toresson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
    Development 128:4769-80. 2001
    ....
  48. pmc Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity
    Carlos M Parras
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch Cedex, C U de Strasbourg, France
    Genes Dev 16:324-38. 2002
    ....
  49. ncbi Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans
    Kunio Kitamura
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Nat Genet 32:359-69. 2002
    ..The present report is, to our knowledge, the first to use phenotypic analysis of a knockout mouse to identify a gene associated with an X-linked human brain malformation...
  50. ncbi DLX5 regulates development of peripheral and central components of the olfactory system
    Jason E Long
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, California 94143 0984, USA
    J Neurosci 23:568-78. 2003
    ..In addition, the mutation has a noncell-autonomous effect on the morphogenesis of mitral cells...
  51. ncbi Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction
    Oscar Marin
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, 401 Parnassus Avenue, University of California San Francisco, CA 94143, USA
    Development 130:1889-901. 2003
    ....
  52. ncbi CXCR4 regulates interneuron migration in the developing neocortex
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:5123-30. 2003
    ..Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development...
  53. ncbi Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Cereb Cortex 13:895-903. 2003
    ..This recovery may be, at least in part, a result of the late migration of Dlx2 progenitors from the caudal ganglionic eminences (CGE), which, based on our previous work, does not appear to require Nkx2.1 gene function...
  54. ncbi Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse
    Nobuaki Tamamaki
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Comp Neurol 467:60-79. 2003
    ..4% of the GFP-positive cells. They accounted for 6.5% in layer I. In accord with unidentified GFP-positive cells, many medium-sized spherical somata emitting intense GFP fluorescence were observed in layer I...
  55. ncbi Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
    Leping Cheng
    The Dana Farber Cancer Institute, and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 7:510-7. 2004
    ..GABAergic markers were derepressed in Tlx mutants, including Pax2 that is necessary for GABAergic differentiation, Gad1/2 and Viaat that regulate GABA synthesis and transport, and the kainate receptors Grik2/3...
  56. pmc Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways
    Carol Schuurmans
    IGBMC, Illkirch, CU de Strasbourg, France
    EMBO J 23:2892-902. 2004
    ..Our study thus reveals an unanticipated heterogeneity in the genetic mechanisms specifying the identity of neocortical projection neurons...
  57. ncbi Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment
    Fabrice Ango
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 119:257-72. 2004
    ..Disruption of NF186-ankyrinG interactions at AIS reduced pinceau synapse formation. These results implicate ankyrin-based localization of L1CAMs in subcellular organization of GABAergic synapses...
  58. ncbi Development of spontaneous mouth/tongue movement and related neural activity, and their repression in fetal mice lacking glutamate decarboxylase 67
    Naoko Tsunekawa
    Obata Research Unit, RIKEN Brain Science Institute, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Eur J Neurosci 21:173-8. 2005
    ....
  59. ncbi Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions
    Irina J Fox
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 79:584-97. 2005
    ..Together, these findings suggest that ErbB receptors might mediate multiple functions in central nervous system development, some of which may be initiated by EGFR/ErbB4 heterodimers in vivo...
  60. ncbi GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons
    Esther Pozas
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S 17177 Stockholm, Sweden
    Neuron 45:701-13. 2005
    ..The lack of involvement of RET or NCAM in these processes suggests the existence of additional transmembrane effectors for GDNF...
  61. pmc Generation and characterization of Rac3 knockout mice
    Sara Corbetta
    Department of Molecular Biology and Functional Genomics, San Raffaele Scientific Institute, 20132 Milan, Italy
    Mol Cell Biol 25:5763-76. 2005
    ..Our results indicate that, in vivo, Rac3 activity is not strictly required for normal development in utero but may be relevant to later events in the development of a functional nervous system...
  62. ncbi The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons
    Ronald R Waclaw
    Division of Developmental Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Neuron 49:503-16. 2006
    ....
  63. ncbi A shared vesicular carrier allows synaptic corelease of GABA and glycine
    Sonja M Wojcik
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Neuron 50:575-87. 2006
    ..Since GABA and glycine compete for vesicular uptake, these data point to a close association of Viaat with GABA-synthesizing enzymes as a key factor in specifying GABAergic neuronal phenotypes...
  64. ncbi Cellular patterns of transcription factor expression in developing cortical interneurons
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158 2611, USA
    Cereb Cortex 16:i82-8. 2006
    ..This study is a first step to define the combinatorial codes of transcription factors that participate in regulating the specification and function of cortical interneuron subtypes...
  65. ncbi Layer acquisition by cortical GABAergic interneurons is independent of Reelin signaling
    Ramón Pla
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 26:6924-34. 2006
    ....
  66. ncbi Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord
    Andrea Pillai
    Biology Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA
    Development 134:357-66. 2007
    ..Lhx1; Lhx5 double-knockout mice exhibit a downregulation of Gad1 and Viaat (Slc32a1) from E13.5 onwards that is closely associated with a decrease in Pax2 expression...
  67. ncbi Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes
    Petros Liodis
    Division of Molecular Neurobiology, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Neurosci 27:3078-89. 2007
    ..We also show that Lhx6 activity is required for the normal tangential and radial migration of GABAergic interneurons in the cortex...
  68. pmc Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation
    Jason E Long
    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:3230-43. 2007
    ....
  69. ncbi Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 27:3884-93. 2007
    ..Moreover, they indicate that Rac1 has a critical role in axon guidance and in acquisition of migratory competency during differentiation of the progenitors for the ventral telencephalon-derived interneurons...
  70. ncbi GABAergic phenotype of periglomerular cells in the rodent olfactory bulb
    P Panzanelli
    Department of Anatomy, Pharmacology, and Forensic Medicine, and Istituto Nazionale di Neuroscienze, University of Turin, I 10126 Torino, Italy
    J Comp Neurol 502:990-1002. 2007
    ..In addition, they show that PG cells provide GABAergic input to the dendrites of principal neurons and are interconnected with other GABAergic interneurons, which most likely are other PG cells...
  71. pmc Dlx transcription factors promote migration through repression of axon and dendrite growth
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 54:873-88. 2007
    ....
  72. ncbi Experimental induction of palate shelf elevation in glutamate decarboxylase 67-deficient mice with cleft palate due to vertically oriented palatal shelf
    Sachiko Iseki
    Department of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo 113 8549, Japan
    Birth Defects Res A Clin Mol Teratol 79:688-95. 2007
    ..In the present study, development of cleft palate was examined histologically and manipulated with culture of the maxilla and partial resection of fetal tongue...
  73. doi A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord
    Dominique Bröhl
    Department of Neuroscience, Max Delbrück Centrum for Molecular Medicine, Berlin, Germany
    Dev Biol 322:381-93. 2008
    ..We conclude that a transcriptional network operates in maturing dorsal horn neurons that coordinately determines transmitter and peptidergic fate...
  74. pmc The role of Robo3 in the development of cortical interneurons
    Melissa Barber
    Department of Cell and Developmental Biology, University College London, London, UK
    Cereb Cortex 19:i22-31. 2009
    ..These observations and the results of other recent studies suggest a complex interplay between the 3 Robo receptors in regulating the number, migration and morphological differentiation of cortical interneurons...
  75. doi Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1
    Tomoyuki Fujiyama
    Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Development 136:2049-58. 2009
    ....
  76. doi Patterning of ventral telencephalon requires positive function of Gli transcription factors
    Weiying Yu
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 334:264-75. 2009
    ..Together, these studies unravel a role for Gli transcription factors in mediating Shh signaling to control specification, differentiation and positioning of ventral telencephalic neurons...
  77. pmc Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1
    Haisong Jiang
    Center for Advanced Biotechnology and Medicine, Department of Pediatrics, and Graduate Program in Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Neurosci 29:10449-59. 2009
    ....
  78. pmc Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates
    Ronald R Waclaw
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Neuron 63:451-65. 2009
    ..These results demonstrate that Gsx2 specifies striatal projection neuron and olfactory bulb interneuron identity at distinct time points during telencephalic neurogenesis...
  79. pmc The cell-intrinsic requirement of Sox6 for cortical interneuron development
    Renata Batista-Brito
    Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Building, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Neuron 63:466-81. 2009
    ..It is, however, necessary for their normal positioning and maturation. As a consequence, the specific removal of Sox6 from this population results in a severe epileptic encephalopathy...
  80. pmc Adult generation of glutamatergic olfactory bulb interneurons
    Monika S Brill
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Neurosci 12:1524-33. 2009
    ..Taken together, our data indicate that SEZ progenitors not only produce a population of adult-born glutamatergic juxtaglomerular neurons, but may also provide a previously unknown source of progenitors for endogenous repair...
  81. pmc Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons
    Goichi Miyoshi
    Smilow Neuroscience Program and the Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 30:1582-94. 2010
    ..Thus, in conjunction with previous studies, we have now determined the spatial and temporal origins of the vast majority of cortical interneuron subtypes...
  82. pmc Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala
    Rebecca L Leshan
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 30:5713-23. 2010
    ..Thus, LepRb VTA neurons represent a subclass of VTA DA neurons that specifically innervates and controls the extCeA; we hypothesize that these neurons primarily modulate CeA-directed behaviors...
  83. pmc Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters
    Jamil Kanaani
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 190:911-25. 2010
    ..Thus two distinct mechanisms target the constitutively active GAD67 to presynaptic clusters to facilitate accumulation of GABA for rapid delivery into synapses...
  84. pmc Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex
    Aaron M Kerlin
    Department of Neurobiology, Harvard Medical School, Goldenson 243, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 67:858-71. 2010
    ..These results suggest that the sensory responses of layer 2/3 GABAergic neurons reflect the pooled activity of the surrounding population--a principle that may generalize across species and sensory modalities...
  85. pmc Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex
    Santos J Franco
    Dorris Neuroscience Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuron 69:482-97. 2011
    ....
  86. doi Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon
    Shengxi Wu
    Department of Morphological Neural Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556 Japan
    Development 138:2499-509. 2011
    ..IPGNs are maintained in the neocortex and may act as progenitors for adult neurogenesis...
  87. pmc Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex
    Marina Vidaki
    Department of Basic Science, Faculty of Medicine, University of Crete, Heraklion, Greece
    Cereb Cortex 22:680-92. 2012
    ..Rac1 is necessary for their transition from G1 to S phase, at least in part by regulating cyclin D levels and retinoblastoma protein phosphorylation...
  88. pmc Differential gene expression in migratory streams of cortical interneurons
    Mary Antypa
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 34:1584-94. 2011
    ....
  89. doi Lateral regions of the rodent striatum reveal elevated glutamate decarboxylase 1 mRNA expression in medium-sized projection neurons
    Stefan Trifonov
    Department of Anatomy and Brain Science, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Eur J Neurosci 35:711-22. 2012
    ..we found that the mouse lateral striatum concentrates medium-sized projection neurons with high-level expression of GAD1, but not of GAD2, mRNA...
  90. pmc Intrinsically determined cell death of developing cortical interneurons
    Derek G Southwell
    Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA
    Nature 491:109-13. 2012
    ..Taken together, our findings indicate that interneuron cell death is determined intrinsically, either cell-autonomously or through a population-autonomous competition for survival signals derived from other interneurons...
  91. ncbi GABAergic neurons in the embryonic olfactory pit/vomeronasal organ: maintenance of functional GABAergic synapses in olfactory explants
    S Wray
    Laboratory of Neurochemistry, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 180:631-45. 1996
    ..However, unlike LHRH neurons, GABAergic neurons did not migrate large distances in olfactory explants or appear to leave the olfactory pit in vivo...
  92. pmc Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation
    Guillermina López-Bendito
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Cell 125:127-42. 2006
    ..These results show that neuronal tangential migration constitutes a novel mechanism to control the timely arrangement of guidance cues required for axonal tract formation in the mammalian brain...
  93. ncbi Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene
    S O Castillo
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1766, USA
    Genomics 41:250-7. 1997
    ..These data help to explain the different response characteristics of two closely related early response genes, Nurr1 and Nur77...
  94. ncbi Differential localization of septins in the mouse brain
    A Kinoshita
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    J Comp Neurol 428:223-39. 2000
    ....
  95. ncbi Gamma-aminobutyric acidB receptors and the development of the ventromedial nucleus of the hypothalamus
    Aline M Davis
    The Shriver Center, University of Massachusetts Medical School, 200 Trapelo Road, Waltham, MA 02452, USA
    J Comp Neurol 449:270-80. 2002
    ..The percentage of cells moving per field and the angles of cell movement were not affected. With our previous findings of GABA(A) receptor activation, it is likely that GABA influences VMH development via multiple mechanisms...
  96. ncbi BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2
    Fernando Aguado
    Department of Cell Biology Faculty of Biology, and Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
    Development 130:1267-80. 2003
    ..Given that BDNF itself is regulated by neuronal activity, we suggest that BDNF acts as a homeostatic factor controlling the emergence, complexity and networking properties of spontaneous networks...
  97. ncbi Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons
    Elena Colombo
    Stem Cell Research Institute, DIBIT, San Raffaele Science Park, Via Olgettina 58, 20132 Milan, Italy
    Dev Dyn 231:631-9. 2004
    ..during differentiation of the subpallial structures of the ganglionic eminences, overlapping with Dlx2, Dlx5, and Gad1 transcriptional domains...
  98. ncbi Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
    Leping Cheng
    Dana Farber Cancer Institute, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 8:1510-5. 2005
    ..These genetic studies suggest that Lbx1 expression defines a basal GABAergic differentiation state, and Tlx3 acts to antagonize Lbx1 to promote glutamatergic differentiation...
  99. pmc Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression
    Marta Pascual
    Institut de Recerca Biomèdica, Parc Cientific de Barcelona, Universitat de Barcelona, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 104:5193-8. 2007
    ..Moreover, our results suggest that Ptf1a is also required for the suppression of the granule cell specification program in cerebellar ventricular zone precursors...
  100. ncbi GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5
    Andrea Kwakowsky
    Department of Gene Technology and Developmental Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Dev Dyn 236:3532-44. 2007
    ..GABA and GAD are most abundant at the tips of elongating fibers and are absent from organelle-free cells, suggesting their involvement is primarily in shaping of the cytoskeleton during fiber elongation stages...
  101. ncbi Phenotype of V2-derived interneurons and their relationship to the axon guidance molecule EphA4 in the developing mouse spinal cord
    Line Lundfald
    Mammalian Locomotor Laboratory, Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Eur J Neurosci 26:2989-3002. 2007
    ..Together, these findings enable a better interpretation of neural networks underlying locomotion, and open up the search for as yet unknown components of the mammalian central pattern generator...

Research Grants4

  1. Role of Pitx2 in the Mammalian Central Nervous System
    Donna Martin; Fiscal Year: 2005
    ..5-14.5) mouse diencephalon, 2) Develop and analyze mice with Pitx2 loss of function, and 3) Develop and analyze transgenic mice with CNS-specific Pitx2 gain of function. ..
  2. Pitx2 Function in Developing Mouse Brain Neurons
    Donna M Martin; Fiscal Year: 2010
    ..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..
  3. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..
  4. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..