Fut4

Summary

Gene Symbol: Fut4
Description: fucosyltransferase 4
Alias: AI451562, CD15, FAL, FucT-IV, LeX, SSEA-1, Ssea1, alpha-(1,3)-fucosyltransferase 4, 3-fucosyl-N-acetyl-lactosamine epitope, Lewis x, alpha (1,3) fucosyltransferase, myeloid specific, alpha 1,3-fucosyltransferase, fuc-TIV, fucosyltransferase IV, galactoside 3-L-fucosyltransferase, stage-specific embryonic antigen 1
Species: mouse

Top Publications

  1. pmc Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo
    Suzannah A Williams
    Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Glycoconj J 26:335-47. 2009
  2. ncbi The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis
    P Maly
    Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109 0650, USA
    Cell 86:643-53. 1996
  3. ncbi Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells
    R C Marcus
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Comp Neurol 403:346-58. 1999
  4. ncbi Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits
    L Erskine
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 20:4975-82. 2000
  5. ncbi Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels
    W Weninger
    The Center for Blood Research and Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 12:665-76. 2000
  6. ncbi Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling
    S Chuma
    Mammalian Development Laboratory, National Institute of Genetics, Mishima, Japan
    Dev Biol 229:468-79. 2001
  7. ncbi The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing
    J W Homeister
    Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Immunity 15:115-26. 2001
  8. pmc Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes
    G Smithson
    Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Exp Med 194:601-14. 2001
  9. ncbi Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system
    Andrew S Plump
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:219-32. 2002
  10. ncbi LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal
    Alexandra Capela
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Neuron 35:865-75. 2002

Scientific Experts

  • Thomas Pratt
  • Mehdi Pirouz
  • Mitsuru Morimoto
  • Diana J Laird
  • Lynda Erskine
  • Jiaxi Ding
  • Luisa Campagnolo
  • Kazuko Handa
  • Fernando Anjos-Afonso
  • Lan Zhou
  • N Galili
  • R A Rachel
  • Imo E Hoefer
  • Jonathon W Homeister
  • S Ehlers
  • Natalia Abramova
  • R C Marcus
  • John B Lowe
  • Xiaodong Jiang
  • John R Harp
  • Yasuo Ouchi
  • Nan Zhang
  • Alexandra Capela
  • Ling Lin
  • Hideto Koso
  • EunSook Park
  • Jingjing Sun
  • Melinda E Snitow
  • Y Q Shirleen Soh
  • Rebecca J Richardson
  • Ripla Arora
  • Hiroshi Kurosaka
  • Michael J Dixon
  • Mark E Gill
  • Huili Wang
  • David C Page
  • Jun ichi Iwata
  • Takaaki Kuwajima
  • Giselly Encinas
  • Felicity C Stark
  • Hirokazu Yagi
  • Dil Afroz Sultana
  • J K Mai
  • Thomas S Kupper
  • Lea A Medeiros
  • Pasqualino De Antonellis
  • K Y Chung
  • Chunmei Wang
  • Maria Nacher
  • Mayumi Hirose
  • Hanayo Arata-Kawai
  • Ronan Le Bouffant
  • Forugh Vaziri Sani
  • Yu Hui Wong
  • Thandi M Onami
  • Rui Zhu
  • Vesa Kaartinen
  • Tomomasa Yokomizo
  • Cristina Patru
  • Yiming Xing
  • K M Leung
  • Luzheng Liu
  • Shinichiro Chuma
  • George R Miesegaes
  • Jan Pruszak
  • Tracy Ann Read
  • Suzannah A Williams
  • Yaozhong Ding
  • Girdhari Lal
  • Sumiko Watanabe
  • Makoto M Taketo
  • Jonathan S Bromberg
  • Jordi C Ochando
  • Carol Mason
  • K W Ashwell
  • Minoru Fukuda
  • Hiroto Kawashima
  • Cristina Sánchez-Camacho
  • Cornelia Doebis
  • Levi G Ledgerwood
  • S O Chan
  • Yoshiyuki Seki
  • Madeliene E Gainers
  • Keely M Bumsted-O'Brien
  • Erika A Bosman
  • Christopher Runyan
  • Danielle M Maatouk
  • J B Lowe
  • Yi Hong Cai
  • Tohru Kimura

Detail Information

Publications112 found, 100 shown here

  1. pmc Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo
    Suzannah A Williams
    Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Glycoconj J 26:335-47. 2009
    ..Furthermore, neither of these classes of glycan is essential for the expression of SSEA-1, SSEA-3, SSEA-4 or Le(Y) on mouse embryos...
  2. ncbi The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis
    P Maly
    Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109 0650, USA
    Cell 86:643-53. 1996
    ..These observations demonstrate an essential role for Fuc-TVII in E-, P-, and L-selectin ligand biosynthesis and imply that this locus can control leukocyte trafficking in health and disease...
  3. ncbi Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells
    R C Marcus
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Comp Neurol 403:346-58. 1999
    ..Together, these data support the hypothesis that molecularly distinct, longitudinally aligned domains in the forebrain regulate the pattern of retinal axon projections in the developing hypothalamus...
  4. ncbi Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits
    L Erskine
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 20:4975-82. 2000
    ....
  5. ncbi Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels
    W Weninger
    The Center for Blood Research and Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 12:665-76. 2000
    ..These results demonstrate a role for FucT-IV in selectin-dependent adhesion and suggest that the endothelial selectins and FucTs have distinct but overlapping functions in the immunosurveillance of the skin...
  6. ncbi Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling
    S Chuma
    Mammalian Development Laboratory, National Institute of Genetics, Mishima, Japan
    Dev Biol 229:468-79. 2001
    ..This novel activity of gp130-mediated signaling may provide some clues for the understanding of pluripotency of mammalian germ-line cells and/or the sex differentiation of fetal germ cells...
  7. ncbi The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing
    J W Homeister
    Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Immunity 15:115-26. 2001
    ..These observations reveal essential FucT-IV-dependent contributions to E-, P-, and L-selectin ligand synthesis and to the control of leukocyte recruitment and lymphocyte homing...
  8. pmc Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes
    G Smithson
    Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Exp Med 194:601-14. 2001
    ....
  9. ncbi Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system
    Andrew S Plump
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:219-32. 2002
    ..Our results indicate that Slit proteins repel retinal axons in vivo and cooperate to establish a corridor through which the axons are channeled, thereby helping define the site in the ventral diencephalon where the optic chiasm forms...
  10. ncbi LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal
    Alexandra Capela
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Neuron 35:865-75. 2002
    ..We show that Lewis X (LeX), a carbohydrate expressed by embryonic pluripotent stem cells, is made by adult mouse subventricular zone (..
  11. pmc Normal embryonic and germ cell development in mice lacking alpha 1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1
    Takashi Kudo
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory, Tsukuba, Ibaraki 305 8568, Japan
    Mol Cell Biol 24:4221-8. 2004
    Stage-specific embryonic antigen 1 (SSEA-1), an antigenic epitope defined as a Lewis x carbohydrate structure, is expressed during the 8-cell to blastocyst stages in mouse embryos and in primordial germ cells, undifferentiated embryonic ..
  12. ncbi The roles of FGF signaling in germ cell migration in the mouse
    Yutaka Takeuchi
    Department of Marine Biosciences, Tokyo University of Marine Science and Technology, 4 5 7 Konan, Minato ku, Tokyo 108 8477, Japan
    Development 132:5399-409. 2005
    ..These data show that a major role of FGF signaling through FGFR2-IIIb is to control germ cell numbers. The data do not discriminate between direct and indirect effects of FGF signaling on germ cells, and both may be involved...
  13. ncbi Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart
    Yi Hong Cai
    Vascular Research Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:6568-75. 2006
    ..These results identify a prominent role for selectin ligands in contributing to effector CD8+ T cell recruitment into the myocardium and indicate that selectin-dependent T cell recruitment is relevant to other tissues besides the skin...
  14. ncbi Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration
    Christopher Runyan
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 133:4861-9. 2006
    ..These data show first that changing expression of Steel factor is required for normal midline germ cell death, and second, that Steel factor is required for normal proliferation and migration of germ cells...
  15. ncbi Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice
    Yoshiyuki Seki
    Laboratory for Mammalian Germ Cell Biology, Center for Developmental Biology, RIKEN Kobe Institute, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
    Development 134:2627-38. 2007
    ..We suggest the possibility that active repression of an essential enzyme and subsequent unique cellular dynamics ensures successful implementation of genome-wide epigenetic reprogramming in migrating PGCs...
  16. doi Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons
    Cristina Sánchez-Camacho
    Departamento de Neurobiología Molecular Celular y del Desarrollo, Instituto Cajal, CSIC and CIBER de Enfermedades Raras CIBERER 37, Madrid 28002, Spain
    Development 135:3531-41. 2008
    ....
  17. pmc Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    Tracy Ann Read
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:135-47. 2009
    ..Patched mutant mouse, are propagated not by CD133(+) cells but by cells expressing the progenitor markers Math1 and CD15/SSEA-1...
  18. doi Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis
    Stefan Ehlers
    Molecular Inflammation Medicine, Christian Albrechts Universitat, Kiel, Germany Microbial Inflammation Research, Research Center Borstel, Parkallee 1, 23845 Borstel, Borstel, Germany
    Immunobiology 214:674-82. 2009
    ..These results suggest that targeting selectin ligand function during treatment of chronic inflammatory disorders may run the risk of accelerating TB disease progression...
  19. pmc Signaling via Alk5 controls the ontogeny of lung Clara cells
    Yiming Xing
    Department of Pediatrics, Division of Neonatology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 137:825-33. 2010
    ..Thus, the signaling pathway by which TGFbeta/ALK5 regulates Clara cell differentiation may entail inhibition of Pten expression, which in turn activates ERK and AKT phosphorylation...
  20. pmc Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4
    Xiaodong Jiang
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:7443-8. 2010
    ..DETC were significantly reduced in CCR4(-/-) mice but were present at normal levels in CCR10(-/-) mice. Our results present evidence for the crucial role of trafficking molecules in embryonic migration of DETC precursors to skin...
  21. pmc Naïve T cells re-distribute to the lungs of selectin ligand deficient mice
    John R Harp
    Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA
    PLoS ONE 5:e10973. 2010
    ..T cell extravasation into lymph nodes via high endothelial venules and is dependent on the biosynthesis of sialyl Lewis X (sLe(x)) ligands by several glycosyltransferases, including two fucosyltransferases, fucosyltransferase-IV and -..
  22. doi Biosynthesis and distribution of Lewis X- and Lewis Y-containing glycoproteins in the murine male reproductive system
    Chunmei Wang
    Shanghai Key Laboratory of Molecular Andrology, State Key Laboratory of Molecular Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Glycobiology 21:225-34. 2011
    Although Lewis X (LeX) and Lewis Y (LeY) antigens were thought to play important roles in fertility, fucosyltransferase (Fut)-deficient (Fut1, Fut2 and Fut4) mice which lack LeX or LeY antigen are still fertile...
  23. doi Memory T cells are enriched in lymph nodes of selectin-ligand-deficient mice
    John R Harp
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 185:5751-61. 2010
    ..These results suggest that memory T cells are enriched in LNs with T cell deficits by several mechanisms, including longer T cell retention and increased homeostatic proliferation...
  24. pmc Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects
    Lea A Medeiros
    Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:14163-8. 2011
    ..Female mir-290-295(-/-) mice are unable to recover and are sterile, due to premature ovarian failure...
  25. pmc Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1)
    D Solter
    Proc Natl Acad Sci U S A 75:5565-9. 1978
    ..This stage-specific antigen (SSEA-1) is first detected on blastomeres of 8-cell stage embryos. Trophectodermal cells are transitorily positive; however, each cell in the inner cell mass eventually expresses this antigen...
  26. ncbi Expression of chondroitin sulfate proteoglycans in the chiasm of mouse embryos
    K Y Chung
    Department of Anatomy, Chinese University of Hong Kong, People s Republic of China
    J Comp Neurol 417:153-63. 2000
    ....
  27. ncbi Multipotentiality, homing properties, and pyramidal neurogenesis of CNS-derived LeX(ssea-1)+/CXCR4+ stem cells
    Stefania Corti
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Foundation, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    FASEB J 19:1860-2. 2005
    ..We isolated a primitive neural stem cell subset, double positive for LeX(Le) and CXCR4(CX) antigens that possesses CNS homing potential and extensive neuronal repopulating capacity...
  28. ncbi LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1
    Alexandra Capela
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Dev Biol 291:300-13. 2006
    LeX/SSEA1/CD15 is an extracellular matrix-associated carbohydrate expressed by ES cells and by adult neural and bone marrow stem cells...
  29. ncbi The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
    Levi G Ledgerwood
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 9:42-53. 2008
    ..Thus, the increased sphingosine 1-phosphate present in inflamed peripheral tissues may induce T cell retention and suppress T cell egress...
  30. doi Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and in the nasal cavity of the mouse
    Forugh Vaziri Sani
    Department of Oral Biochemistry, Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    Eur J Oral Sci 118:221-36. 2010
    ..The hitherto-unknown innervation pattern of the developing palate was revealed. These findings may be of value for unravelling the pathogenesis of palatal clefting...
  31. doi Detection of four germ cell markers in rats during testis morphogenesis: differences and similarities with mice
    Giselly Encinas
    Laboratory of Developmental Biology, Department of Morphology and Genetics, Federal University of Sao Paulo, Sao Paulo, Brazil
    Cells Tissues Organs 195:443-55. 2012
    ..germ cell nuclear antigen 1 (GCNA1), OCT4, mouse vasa homologue (MVH) and specific surface embryonic antigen 1 (SSEA1) were immunolabeled at different phases of embryonic and postnatal development...
  32. pmc MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma
    Pasqualino De Antonellis
    Centro di Ingegneria Genetica e Biotecnologia Avanzate, CEINGE, Naples, Italy
    PLoS ONE 6:e24584. 2011
    ..On the basis of this evidence, we hypothesized that miRNAs targeting the Notch pathway can regulate these phenomena, and can be used in anti-cancer therapies...
  33. doi Binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH
    Mayumi Hirose
    Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    Biochem Biophys Res Commun 414:437-42. 2011
    ..6. Consistently, optimal binding of soluble recombinant L-selectin to a major vascular ligand, 6-sulfo sialyl Lewis X, was observed at pH 7.4...
  34. doi Msx1 and Msx2 promote meiosis initiation
    Ronan Le Bouffant
    CEA, DSV iRCM SCSR LDG, Laboratoire de Développement des Gonades, Unité Cellules Souches et Radiation, F 92265 Fontenay aux Roses, France
    Development 138:5393-402. 2011
    ..Collectively, our data demonstrate for the first time that some homeobox genes are required for meiosis initiation in the female germ line...
  35. pmc Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
    Xiaodong Jiang
    Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 483:227-31. 2012
    ..These findings have important implications for our understanding of protective immune memory at epithelial interfaces with the environment, and suggest novel strategies for vaccines that protect against tissue tropic organisms...
  36. pmc Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated
    Dil Afroz Sultana
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 188:4385-93. 2012
    ..These studies provide insight into the developmentally regulated expression of a critical determinant involved in progenitor homing to the thymus...
  37. pmc α(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis
    Huili Wang
    Department of Pathology and Laboratory Medicine and the McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    Am J Pathol 182:2082-93. 2013
    The α(1,3)-fucosyltransferases, types IV and VII (FUT4 and FUT7, respectively), are required for the synthesis of functional selectin-type leukocyte adhesion molecule ligands...
  38. pmc Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis
    Hiroshi Kurosaka
    J Clin Invest 124:1660-71. 2014
    ....
  39. pmc Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system
    Ripla Arora
    Department of Ob Gyn and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, California
    Dev Dyn 243:1037-45. 2014
    ..Following a recently identified role of Ror2 in the migration of mouse primordial germ cells, we extensively characterized its expression throughout the fetal internal reproductive system and the postnatal ductal system...
  40. pmc Periderm prevents pathological epithelial adhesions during embryogenesis
    Rebecca J Richardson
    J Clin Invest 124:3891-900. 2014
    ..Furthermore, this study suggests that failure of periderm formation underlies a series of devastating birth defects, including popliteal pterygium syndrome, cocoon syndrome, and Bartsocas-Papas syndrome. ..
  41. pmc Ezh2 represses the basal cell lineage during lung endoderm development
    Melinda E Snitow
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 142:108-17. 2015
    ..Together, these findings show that Ezh2 restricts the basal cell lineage during normal lung endoderm development to allow the proper patterning of epithelial lineages during lung formation. ..
  42. pmc A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary
    Y Q Shirleen Soh
    Whitehead Institute, Cambridge, Massachusetts, United States of America Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 11:e1005531. 2015
    ..Collectively, our findings reveal a gene regulatory logic by which germ cells prepare for the chromosomal program of meiotic prophase, and ensure that it is induced only once. ..
  43. doi NUP50 is necessary for the survival of primordial germ cells in mouse embryos
    EunSook Park
    School of Biological Sciences and TechnologyKorea Basic Science Institute Gwangju CenterChonnam National University, Gwangju 500 757, Republic of KoreaDivisions of Clinical Research and Human BiologyFred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA School of Biological Sciences and TechnologyKorea Basic Science Institute Gwangju CenterChonnam National University, Gwangju 500 757, Republic of KoreaDivisions of Clinical Research and Human BiologyFred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Reproduction 151:51-8. 2016
    ..Taken together, these results suggest that NUP50 plays an essential role in the survival of PGCs during embryonic development. ..
  44. doi Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouse
    Jingjing Sun
    Department of Biochemistry and Molecular Biology, Norris Cancer Hospital, University of Southern California, Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Dev Biol 417:11-24. 2016
    ..We also noted a reduction in the expression of Wnt5a and an increase in the expression in Bmp4 in such tissues in Msx1(-/-);Msx2(-/-) mutants, both known effectors of PGC development. ..
  45. ncbi Transient expression of Dp140, a product of the Duchenne muscular dystrophy locus, during kidney tubulogenesis
    M Durbeej
    Department of Animal Physiology, Uppsala University, Sweden
    Dev Biol 181:156-67. 1997
    ..In contrast, no staining was observed in adult kidney. We suggest that Dp140 is a structural component during kidney tubulogenesis but it may also be involved in signal transduction...
  46. ncbi Chiasmatic neurons in the ventral diencephalon of mouse embryos--changes in arrangement and heterogeneity in surface antigen expression
    Ling Lin
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, PR China
    Brain Res Dev Brain Res 158:1-12. 2005
    ..These findings suggest an action of this surface carbohydrate on the control of axon growth and guidance in the mouse optic pathway...
  47. pmc CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells
    Jan Pruszak
    McLean Hospital Harvard Medical School, Center for Neuroregeneration Research, Belmont, Massachusetts 02478, USA
    Stem Cells 27:2928-40. 2009
    ..combinatorial flow cytometric analysis of three distinct populations derived from human embryonic stem cells: (1) CD15(+)/CD29(HI)/CD24(LO) surface antigen expression defined neural stem cells; (2) CD15(-)/CD29(HI)/CD24(LO) revealed ..
  48. pmc Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitment
    Maria Nacher
    Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    Am J Pathol 178:2437-46. 2011
    ..Our results identify additional mechanisms by which CD44 modulates the inflammatory response...
  49. ncbi Stella is a maternal effect gene required for normal early development in mice
    Bernhard Payer
    Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Curr Biol 13:2110-7. 2003
    ..These findings suggest a similar role for STELLA during early human development as in mice and a potential involvement in germ cell tumors...
  50. pmc CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors
    Cristina Patru
    Glial Plasticity lab, Inserm UMR 894, University Paris Descartes, Paris, France
    BMC Cancer 10:66. 2010
    ..Tumor initiating cells (TICs) provide a new paradigm for developing original therapeutic strategies...
  51. pmc Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells
    Felicity C Stark
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 7:e32211. 2012
    ..Mice deficient in α(1,3) Fucosyltransferase IV and VII (FtDKO) lack functional L, P and E selectin ligands...
  52. pmc Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing
    Takaaki Kuwajima
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Neuron 74:676-90. 2012
    ..These findings suggest a mechanism by which a complex of Sema6D, Nr-CAM, and Plexin-A1 at the chiasm midline alters the sign of Sema6D and signals Nr-CAM/Plexin-A1 receptors on RGCs to implement the contralateral RGC projection...
  53. pmc Lewis X-carrying N-glycans regulate the proliferation of mouse embryonic neural stem cells via the Notch signaling pathway
    Hirokazu Yagi
    Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Nagoya 467 8603, Japan
    J Biol Chem 287:24356-64. 2012
    ..We found that Lewis X-carrying N-glycans were specifically displayed on undifferentiated cells, whereas pauci-mannose-type N-glycans ..
  54. pmc Smad4-Irf6 genetic interaction and TGFβ-mediated IRF6 signaling cascade are crucial for palatal fusion in mice
    Jun ichi Iwata
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Development 140:1220-30. 2013
    ..Thus, IRF6 and SMAD4 synergistically regulate the fate of the MEE, and TGFβ-mediated Irf6 activity is responsible for MEE degeneration during palatal fusion in mice...
  55. ncbi Molecular cloning, expression, chromosomal assignment, and tissue-specific expression of a murine alpha-(1,3)-fucosyltransferase locus corresponding to the human ELAM-1 ligand fucosyl transferase
    K M Gersten
    Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109 0650, USA
    J Biol Chem 270:25047-56. 1995
    ..The enzyme can also form the Lewis x determinant from Gal beta 1-4GlcNAc (Km = 2...
  56. ncbi Spontaneous alternation, motor activity, and spatial learning in hot-foot mutant mice
    M Filali
    Universite de Nancy 1, Laboratoire Biologie et Physiologie du Comportement, URA CNRS 1293, Vandoeuvre les Nancy, France
    J Comp Physiol A 178:101-4. 1996
    ..These results indicate that in addition to motor coordination deficits, these cerebellar mutants have deficits in spatial learning and perseverate choices of maze arms...
  57. ncbi Localization of the CD15-epitope in the inner ear of the developing mouse
    A M Meyer zym Gottesberge
    Research Laboratory of Dept of Otorhinolaryngology, Heinrich Heine University of Dusseldorf, Moorenstrasse 5, D 40255 Düsseldorf, Germany
    Cell Tissue Res 283:395-401. 1996
    The expression of the 3-fucosyl-N-acetyl-lactosamine (CD15) epitope during the embryonic development of the mouse inner ear has been immunohistochemically studied on paraffin sections from day 8.5 to day 19 of gestation...
  58. ncbi Transient developmental expression of CD15 in the motor and auditory cortex of the mouse
    K W Ashwell
    School of Anatomy, The University of NSW, Sydney, Australia
    Brain Res Dev Brain Res 100:143-8. 1997
    The distribution of the glycoprotein CD15 (FAL, SSEA-1, Le(x)) in the developing cortex of the mouse has been examined by immunohistochemistry of paraffin sections. The pattern of CD15 immunoreactivity was observed to occur in 4 stages...
  59. ncbi Developmental expression of the CD15-epitope in the brainstem and spinal cord of the mouse
    K W Ashwell
    School of Anatomy, University of NSW, Sydney, Australia
    Anat Embryol (Berl) 196:13-25. 1997
    The expression of the 3-fucosyl-N-acetyl-lactosamine (FAL, CD15, Le(x)) epitope has been examined immunohistochemically in paraffin sections of the brainstem of the mouse...
  60. ncbi Pre- and postnatal expression of glycoconjugates (3-fucosyl-N-acetyllactosamine and HNK-1 epitopes) in the mouse inner ear
    A Meyer zum Gottesberge
    Department of Otorhinolaryngology, Heinrich Heine University of Dusseldorf, Germany
    Int J Dev Neurosci 15:645-56. 1997
    The distribution of two glycoconjugates 3-fucosyl-N-acetyllactosamine (CD15) and HNK-1 epitope (CD57) in the inner ear of the NMRI mouse was analysed from the eighth day of gestation to the 16th day after birth...
  61. ncbi Gscl, a gene within the minimal DiGeorge critical region, is expressed in primordial germ cells and the developing pons
    N Galili
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Dev Dyn 212:86-93. 1998
    ..More detailed immunohistochemistry revealed the GSCL in primordial germ cells during migration from the epithelium of the hindgut and later as they colonize the developing gonads. GSCL was not detected in tissues affected in DGS/VCSF...
  62. ncbi Demarcation of prosencephalic regions by CD15-positive radial glia
    J K Mai
    Institute of Neuroanatomy, Heinrich Heine University, Dusseldorf, Germany
    Eur J Neurosci 10:746-51. 1998
    ..This subpopulation, specified by the putative cell adhesion molecule CD15 (LeX, FAL), is arranged in a segmented pattern within the telencephalon and diencephalon...
  63. ncbi alpha(1,3)fucosyltransferases expressed by the gain-of-function Chinese hamster ovary glycosylation mutants LEC12, LEC29, and LEC30
    S K Patnaik
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York, 10461, USA
    Arch Biochem Biophys 375:322-32. 2000
    ..Using genomic PCR and reverse-transcriptase (RT)-PCR strategies, we isolated coding portions of the CHO Fut4 and Fut9 genes. Each gene is present in a single copy in the CHO and mutant genomes...
  64. ncbi Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6
    R Parker
    Garvan Institute of Medical Research, Neurobiology Program, St Vincent s Hospital, Darlinghurst, Sydney, NSW, Australia
    Biochim Biophys Acta 1491:369-75. 2000
    ..However, although successful cell surface expression in a heterologous expression system can be achieved no specific binding to this ligand family can be detected, indicating that perhaps additional factors are required for binding...
  65. ncbi Nodal and bone morphogenetic protein 5 interact in murine mesoderm formation and implantation
    K C Pfendler
    Department of Pediatrics, Northwestern University Medical School and Developmental Biology Program of the Children s Memorial Institute for Education and Research, Chicago, Illinois 60614, USA
    Genesis 28:1-14. 2000
    ..Our data also reveal an unsuspected role for Bmp-5 in implantation and the decidual response in the mouse...
  66. ncbi Male-to-female sex reversal in mice lacking fibroblast growth factor 9
    J S Colvin
    Department of Molecular Biology and, Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 104:875-89. 2001
    ..While Sry is found only in some mammals, Fgfs are highly conserved. Thus, Fgfs may function in sex determination and reproductive system development in many species...
  67. ncbi Heparan sulfate proteoglycan expression in the optic chiasm of mouse embryos
    K Y Chung
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, People s Republic of China
    J Comp Neurol 436:236-47. 2001
    ..These findings indicate that changes in age-related fiber order in the optic chiasm and optic tract of mouse embryos are possibly regulated by a spatially restricted expression of HS-PGs...
  68. ncbi Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum
    Jason A Carlyon
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    Blood 102:3387-95. 2003
    ..However, murine infection does not require neutrophil PSGL-1 expression, which has important implications for understanding how A phagocytophilum binds and infects neutrophils...
  69. ncbi Conserved role of nanos proteins in germ cell development
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Science 301:1239-41. 2003
    ..Hence, although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates...
  70. ncbi Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid bodies/nuages in male germ cells and forms a complex with snRNPs
    Shinichiro Chuma
    Department of Development and Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Mech Dev 120:979-90. 2003
    ..These results suggest that MTR-1, which would provide novel insights into evolutionary comparison of nuages, functions in assembling snRNPs into cytoplasmic granules in germ cells...
  71. pmc A novel endothelial L-selectin ligand activity in lymph node medulla that is regulated by alpha(1,3)-fucosyltransferase-IV
    Christine M'rini
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 198:1301-12. 2003
    ..Physiologic relevance for this novel activity in medullary microvessels is suggested by the finding that L-selectin-dependent T cell homing to PLNs was partly insensitive to MECA-79 inhibition...
  72. ncbi Haploinsufficiency of Bcl-x leads to male-specific defects in fetal germ cells: differential regulation of germ cell apoptosis between the sexes
    Shinya Kasai
    Department of Development and Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Dev Biol 264:202-16. 2003
    ..Therefore, male germ cell apoptosis, of which the default pathway is similar to that of the female, is likely to be influenced by male gonadal environments...
  73. ncbi Embryonic stem cells expressing both platelet endothelial cell adhesion molecule-1 and stage-specific embryonic antigen-1 differentiate predominantly into epiblast cells in a chimeric embryo
    Tadashi Furusawa
    Development and Differentiation Laboratory, Developmental Biology Department, Insect and Animal Sciences Division, National Institute of Agrobiological Sciences, Ibaraki, 305 8602, Japan
    Biol Reprod 70:1452-7. 2004
    ..These results showed that the expression levels of PECAM-1 and SSEA-1 in ES cells correlated closely with their pluripotency and/or their ability to incorporate into the epiblast of chimeric embryos...
  74. ncbi Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells
    Ian R Adams
    Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, Cambridge, United Kingdom
    Dev Dyn 229:733-44. 2004
    ..mRif1 may be involved in the maintenance of telomere length or pluripotency in the germline and during early mouse development...
  75. ncbi Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms
    Imo E Hoefer
    Research Group for Experimental and Clinical Arteriogenesis at the Department of Cardiology, University of Freiburg, Freiburg, Germany
    Circ Res 94:1179-85. 2004
    ....
  76. ncbi Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells
    Sophie La Salle
    Department of Pharmacology and Therapeutics and The Montreal Children s Hospital Research Institute, McGill University, Montreal, QC, Canada H3H 1P3
    Dev Biol 268:403-15. 2004
    ..Together, the results provide clues to specific roles for the different DNMT family members in de novo and maintenance methylation in the developing testis and ovary...
  77. ncbi The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse
    Thomas Pratt
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Development 131:3773-84. 2004
    ..2, and cell-surface molecules Ephb2, ephrin B2 and SSEA-1 (Fut4) have been correlated to the normally developing retinothalamic projection and we show they are not much altered in ..
  78. ncbi Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice
    Jonathon W Homeister
    Department of Pathology and The Howard Hughes Medical Institute, University of Michigan, M5240 Medical Science I, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Arterioscler Thromb Vasc Biol 24:1897-903. 2004
    ..They also determine the functional contribution of FucT-IV and FucT-VII to shear-dependent tethering of monocytes to P-selectin, a process believed to be required for atherogenesis...
  79. ncbi Foxd1 is required for proper formation of the optic chiasm
    Eloisa Herrera
    Departments of Pathology, Anatomy and Cell Biology and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Development 131:5727-39. 2004
    ....
  80. ncbi Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells
    Natalia Abramova
    Center for Neuropharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Dev Biol 283:269-81. 2005
    ..We used FACS sorting and the LeX surface marker to enrich neural progenitor cells from different embryonic stages and adult and compared their gene ..
  81. pmc Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin
    Takahiro Satoh
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Pathol 167:787-96. 2005
    ....
  82. pmc Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment
    Shihao Chen
    Glycobiology Program, Cancer Research Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Exp Med 202:1679-89. 2005
    ..These findings indicate that L-selectin-mediated NK cell recruitment plays a crucial role in the control of tumor metastasis into secondary lymphoid organs...
  83. ncbi Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis
    Tanja Schreiber
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Germany
    J Immunol 176:1131-40. 2006
    ....
  84. ncbi SSEA-1 marks regionally restricted immature subpopulations of embryonic retinal progenitor cells that are regulated by the Wnt signaling pathway
    Hideto Koso
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Dev Biol 292:265-76. 2006
    ..Here, we identified SSEA-1 (CD15) as a novel surface antigen that can be used to define immature retinal progenitor cells...
  85. ncbi Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm
    Thomas Pratt
    Genes and Development Group, Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:6911-23. 2006
    ....
  86. ncbi DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages
    Danielle M Maatouk
    Department of Molecular Genetics and Microbiology, PO Box 100266, University of Florida, Gainesville, FL 32610 0266, USA
    Development 133:3411-8. 2006
    ..This is the first example of ectopic gene activation in Dnmt1 mutant mice and suggests that dynamic changes in DNA methylation regulate tissue-specific gene expression of a set of primordial germ cell-specific genes...
  87. ncbi Nonhematopoietic/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment
    Fernando Anjos-Afonso
    Haematopoietic Stem Cell Lab, Cancer Research UK, London Research Institute, UK
    Blood 109:1298-306. 2007
    ..Altogether we are proposing a hierarchical organization of the mesenchymal compartment, placing SSEA-1+ cells at the apex of this hierarchy...
  88. ncbi Le(x) glycan mediates homotypic adhesion of embryonal cells independently from E-cadherin: a preliminary note
    Kazuko Handa
    Division of Biomembrane Research, Pacific Northwest Research Institute, Department of Pathobiology, University of Washington, Seattle, WA 98122, USA
    Biochem Biophys Res Commun 358:247-52. 2007
    ..Thus, ES or EC cells display autoaggregation and strong adhesion to Le(x)-coated plates in the absence of Ecad, further supporting the notion of Le(x) self-recognition (i.e., Le(x)-to-Le(x) interaction) in cell adhesion...
  89. ncbi Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina
    Keely M Bumsted-O'Brien
    Department of Neuroanatomy, Max Planck Institute for Brain Research, Deutschordenst 46, 60218 Frankfurt, Germany
    J Comp Neurol 505:58-72. 2007
    ....
  90. pmc Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis
    Madeliene E Gainers
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:8509-18. 2007
    ....
  91. pmc Expression of EGFL7 in primordial germ cells and in adult ovaries and testes
    Luisa Campagnolo
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Gene Expr Patterns 8:389-96. 2008
    ..Our results provide the first evidence of a non-endothelial expression of EGFL7 and suggest distinctive roles for Egfl7 in vascular development and germ cell differentiation...
  92. pmc Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction
    Cornelia Doebis
    Départemente of Experimentelle Rheumatologie, Charite, Campus Mitte, Berlin, Germany
    Am J Pathol 173:1067-76. 2008
    ..However, only the presence of selectin ligands on T cells was critical for the inflammatory reaction. These findings reveal T cells as the predominant targets for selectin blockade that aim to suppress skin inflammation...
  93. pmc Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse
    Jiaxi Ding
    Department of Genetics Case Western Reserve University, Cleveland, OH, USA
    BMC Dev Biol 8:120. 2008
    ..Primordial germ cells (PGCs) are the embryonic precursors of the sperm and eggs. Environmental or genetic defects that alter PGC development can impair fertility or cause formation of germ cell tumors...
  94. pmc Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
    Nan Zhang
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Immunity 30:458-69. 2009
    ..These results showed that sequential migration from blood to the target tissue and to dLNs is required for Treg cells to differentiate and execute fully their suppressive function...
  95. doi Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation
    Yu Hui Wong
    Institute of Neuroscience and Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, Taipei 112, Taiwan
    J Neurosci 30:4428-39. 2010
    ....
  96. pmc Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors
    Rui Zhu
    Department of Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 70:7264-72. 2010
    ..Our data indicate that Sf1 levels in mouse strains correlate with their incidences of TGCTs and implicate the importance of splicing mechanisms in germ cell tumorigenesis...
  97. pmc Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos
    Tomomasa Yokomizo
    Erasmus MC Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
    Development 137:3651-61. 2010
    ..Clusters enriched with the c-Kit(+)CD31(+)SSEA1(-) cell population contain functional hematopoietic progenitors and stem cells...
  98. pmc Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs
    Hanayo Arata-Kawai
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Am J Pathol 178:423-33. 2011
    ..These findings extend the evidence for the importance of N-glycans in lymphocyte homing in mouse and indicate that this dependency also applies to human lymphoid organs...
  99. doi β-Catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells
    Yasuo Ouchi
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, 108 8639 Tokyo, Japan
    Mol Cell Neurosci 46:770-80. 2011
    ..Taken together, β-catenin signaling regulates the timing of differentiation in RPCs by inhibiting premature differentiation of them partly through the regulation of Id3 expression...