Genomes and Genes
Gene Symbol: Fus
Description: fused in sarcoma
Alias: D430004D17Rik, D930039C12Rik, Fus1, Tls, RNA-binding protein FUS, fusion, derived from t(12;16) malignant liposarcoma, hnRNP P2, pigpen protein, protein pigpen, translocated in liposarcoma
- A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampusTakeshi Takarada
Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
J Neurochem 110:1457-68. 2009..Immunoprecipitation analysis revealed the interaction between Myo6 and the RNA-binding protein, translocated in liposarcoma (TLS), while TLS was predominantly expressed by neurons in the cortex, striatum, cerebellum, and ..
- Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcriptionXiangting Wang
Howard Hughes Medical Institute
Nature 454:126-30. 2008..Here we show that an RNA-binding protein, TLS (for translocated in liposarcoma), serves as a key transcriptional regulatory sensor of DNA damage signals that, on the basis of its ..
- Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutationsMiranda L Tradewell
Department of Neurology Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
Hum Mol Genet 21:136-49. 2012Mutations in FUS/TLS (fused in sarcoma/translated in liposarcoma) cause an inheritable form of amyotrophic lateral sclerosis (ALS6)...
- The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granulesKyota Yasuda
Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
J Cell Biol 203:737-46. 2013..Here, we show that APC-RNPs associate with the RNA-binding protein Fus/TLS (fused in sarcoma/translocated in liposarcoma)...
- Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutationsYoshihiro Kino
Laboratory for Structural Neuropathology, Brain Science Institute, RIKEN, 2 1, Hirosawa, Wako Shi, Saitama, 351 0198, Japan
Nucleic Acids Res 39:2781-98. 2011TLS (translocated in liposarcoma), also known as FUS (fused in sarcoma), is an RNA/DNA-binding protein that plays regulatory roles in transcription, pre-mRNA splicing and mRNA transport...
- TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cellsClaudia Colombrita
Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy
J Biol Chem 287:15635-47. 2012The RNA-binding proteins TDP-43 and FUS form abnormal cytoplasmic aggregates in affected tissues of patients with amyotrophic lateral sclerosis and frontotemporal lobar dementia...
- Tumour suppressor Fus1 provides a molecular link between inflammatory response and mitochondrial homeostasisRoman Uzhachenko
Department of Medicine, Division of Hematology Oncology, Vanderbilt University Medical Center, Nashville, TN, USA
J Pathol 227:456-69. 2012b>Fus1, encoded by a 3p21.3 tumour suppressor gene, is down-regulated, mutated or lost in the majority of inflammatory thoracic malignancies...
- Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptionsShinsuke Ishigaki
Department of Neurology, Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
Sci Rep 2:529. 2012b>FUS is an RNA-binding protein that regulates transcription, alternative splicing, and mRNA transport. Aberrations of FUS are causally associated with familial and sporadic ALS/FTLD...
- Widespread binding of FUS along nascent RNA regulates alternative splicing in the brainBoris Rogelj
Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, De Crespigny Park, London, UK
Sci Rep 2:603. 2012Fused in sarcoma (FUS) and TAR DNA-binding protein 43 (TDP-43) are RNA-binding proteins pathogenetically linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but it is not known if they regulate the ..
- Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAsClotilde Lagier-Tourenne
Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California, USA
Nat Neurosci 15:1488-97. 2012FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia...
- Identification and characterization of FUS/TLS as a new target of ATMMary Gardiner
MRC Protein Phosphorylation Unit, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, UK
Biochem J 415:297-307. 2008..This resulted in the identification of FUS (fused in sarcoma)/TLS (translocated in liposarcoma) as an in vitro target of the PIKKs...
- RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cellsHiroshi Doi
Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, 2 1 Hirosawa Wako shi, Saitama, Japan
J Biol Chem 283:6489-500. 2008..As a result, we found that the RNA-binding protein translocated in liposarcoma (TLS) was one of the major components of nuclear polyQ aggregate-interacting proteins in a Huntington ..
- TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spinesRitsuko Fujii
Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
J Cell Sci 118:5755-65. 2005b>TLS (translocation in liposarcoma), an RNA-binding protein, was originally identified as a heterogeneous ribonuclear protein (hnRNP)...
- The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphologyRitsuko Fujii
Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
Curr Biol 15:587-93. 2005..TLS (translocated in liposarcoma), previously identified as a component of hnRNP complexes, unexpectedly showed somatodendritic ..
- Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal deathG G Hicks
Manitoba Institute of Cell Biology and the University of Manitoba, Winnipeg, Canada
Nat Genet 24:175-9. 2000The gene FUS (also known as TLS (for translocated in liposarcoma) and hnRNP P2) is translocated with the gene encoding the transcription factor ERG-1 in human myeloid leukaemias...
- Male sterility and enhanced radiation sensitivity in TLS(-/-) miceM Kuroda
Skirball Institute of Biomolecular Medicine, the Departments of Medicine, Cell Biology and the Kaplan Cancer Center, NYU Medical Center, New York, NY 10016, USA
EMBO J 19:453-62. 2000b>TLS (also known as FUS) is an RNA-binding protein that contributes the N-terminal half of fusion oncoproteins implicated in the development of human liposarcomas and leukemias...
- Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicingL Yang
Medical Research Service, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
J Biol Chem 273:27761-4. 1998The gene encoding the human TLS protein, also termed FUS, is located at the site of chromosomal translocations in human leukemias and sarcomas where it forms a chimeric fusion gene with one of several different genes...
- Loss of mitochondrial protein Fus1 augments host resistance to Acinetobacter baumannii infectionM Indriati Hood
Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee
Infect Immun 81:4461-9. 2013b>Fus1 is a tumor suppressor protein with recently described immunoregulatory functions. Although its role in sterile inflammation is being elucidated, its role in regulating immune responses to infectious agents has not been examined...
- ALS-associated mutations in FUS disrupt the axonal distribution and function of SMNEwout J N Groen
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
Hum Mol Genet 22:3690-704. 2013Mutations in the RNA binding protein fused in sarcoma/translated in liposarcoma (FUS/TLS) cause amyotrophic lateral sclerosis (ALS)...
- Interaction of FUS and HDAC1 regulates DNA damage response and repair in neuronsWen yuan Wang
1 Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA 2 Howard Hughes Medical Institute, Chevy Chase, Maryland, USA 3
Nat Neurosci 16:1383-91. 2013..We found that FUS, an RNA/DNA-binding protein that has been linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar ..
- Highly efficient targeted mutagenesis in mice using TALENsSudeepta Kumar Panda
Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Munich, Germany
Genetics 195:703-13. 2013..we introduced amyotrophic lateral sclerosis patient-derived missense mutations in the fused in sarcoma (Fus) gene at a rate of 6.8%...
- PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damageStuart L Rulten
Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RQ, UK and School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG
Nucleic Acids Res 42:307-14. 2014..this disease encode proteins involved in RNA processing, including fused-in-sarcoma/translocated-in-sarcoma (FUS/TLS)...
- A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1E M Yazlovitskaya
Department of Medicine, Division of Nephrology, Vanderbilt University, Nashville, TN 37232, USA
Cell Death Dis 4:e687. 2013b>FUS1/TUSC2 is a mitochondrial tumor suppressor with activity to regulate cellular oxidative stress by maintaining balanced ROS production and mitochondrial homeostasis...
- The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF)Agnieszka Bronisz
From the Department of Molecular and Cellular Biochemistry, Comprehensive Cancer Center, and
J Biol Chem 289:326-34. 2014..Here, we demonstrate that the proto-oncogene fused in sarcoma (FUS), the chromatin remodeling ATPase BRG1, and MITF form a trimeric complex that is regulated by phosphorylation of ..
- Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALSMélanie Lalancette-Hébert
Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
Proc Natl Acad Sci U S A 113:E8316-E8325. 2016..ALS expressing mutant superoxide dismutase-1 (SOD1), TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS), we demonstrate selective degeneration of alpha MNs (α-MNs) and complete sparing of gamma MNs (γ-MNs), which ..
- ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defectsHaiyan Qiu
J Clin Invest 124:981-99. 2014Autosomal dominant mutations of the RNA/DNA binding protein FUS are linked to familial amyotrophic lateral sclerosis (FALS); however, it is not clear how FUS mutations cause neurodegeneration...
- Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanismsTatyana A Shelkovnikova
School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK, Institute of Physiologically Active Compounds Russian Academy of Sciences, 1 Severniy Proezd, Chernogolovka 142432, Moscow Region, Russian Federation and
Hum Mol Genet 23:5211-26. 2014Fused in sarcoma (FUS) is an RNA-binding protein involved in pathogenesis of several neurodegenerative diseases...
- Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neuronsHyun Hee Ryu
Department of Biotechnology and Biological Sciences, Hannam University, Daejeon, Korea Department of Life Science, Chung Ang University, Seoul, Korea
Neurobiol Aging 35:2822-31. 2014Mutations in fused in sarcoma (FUS), a DNA/RNA binding protein, have been associated with familial amyotrophic lateral sclerosis (fALS), which is a fatal neurodegenerative disease that causes progressive muscular weakness and has ..
- Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1Michael Tibshirani
Montreal Neurological Institute and Department of Neurology Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B4
Hum Mol Genet 24:773-86. 2015Mutations in the RNA-binding protein FUS/TLS (FUS) have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS)...
- Activity-dependent FUS dysregulation disrupts synaptic homeostasisChantelle F Sephton
Departments of Neuroscience and Institut Universitaire en Santé Mentale de Québec, Department of Psychiatry and Neuroscience, Universite Laval, Quebec City, QC, Canada G1J 2G3
Proc Natl Acad Sci U S A 111:E4769-78. 2014The RNA-binding protein fused-in-sarcoma (FUS) has been associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two neurodegenerative disorders that share similar clinical and pathological ..
- ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNPShuying Sun
1 Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA 2 Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
Nat Commun 6:6171. 2015The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), is demonstrated to directly bind to the U1-snRNP and SMN complexes...
- FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosisYoshihiro Kino
Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan
Acta Neuropathol Commun 3:24. 2015b>FUS/TLS is an RNA-binding protein whose genetic mutations or pathological inclusions are associated with neurological diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration, and essential tremor (ET)...
- FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilizationTsuyoshi Udagawa
1 Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan 2 Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
Nat Commun 6:7098. 2015b>FUS is an RNA/DNA-binding protein involved in multiple steps of gene expression and is associated with amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration (FTLD)...
- Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motifHannah K Robinson
a School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff, UK
Amyotroph Lateral Scler Frontotemporal Degener 16:402-9. 2015Mutations to the RNA binding protein, fused in sarcoma (FUS) occur in ∼5% of familial ALS and FUS-positive cytoplasmic inclusions are commonly observed in these patients...
- ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of functionAarti Sharma
Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, 630 W 168th Street, P and S Building, Room 5 423, New York, New York 10032, USA
Nat Commun 7:10465. 2016Mutations in FUS cause amyotrophic lateral sclerosis (ALS), including some of the most aggressive, juvenile-onset forms of the disease...
- Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106Douglas M Anderson
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 Senator Paul D Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390
Proc Natl Acad Sci U S A 113:E4494-503. 2016..These findings reveal a central role for Zfp106 in the maintenance of nerve-muscle signaling, and highlight the involvement of aberrant RNA processing in neuromuscular disease pathogenesis. ..
- Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated MicrocephalyHanqian Mao
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America
PLoS Genet 12:e1006282. 2016..Altogether our study reveals new mechanisms to help explain how EJC mutations influence neurogenesis and underlie neurodevelopmental disease. ..
- PGC-1α regulates translocated in liposarcoma activity: role in oxidative stress gene expressionCristina Sánchez-Ramos
Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain
Antioxid Redox Signal 15:325-37. 2011b>Translocated in liposarcoma (TLS) is a poorly characterized multifunctional protein involved in the genotoxic response...
- TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cellsJing Pan
Departments of Orthopedics and Medicine Hematology, University of Washington, 1660 South Columbian Way, GMR 151, Seattle, WA 98108
Mol Cancer Res 6:862-72. 2008b>TLS-ERG fusion protein is derived from the t(16;21) translocation found in human myeloid leukemia...
- FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stressReddy Ranjith K Sama
Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Cell Physiol 228:2222-31. 2013FUsed in Sarcoma/Translocated in LipoSarcoma (FUS/TLS or FUS) has been linked to several biological processes involving DNA and RNA processing, and has been associated with multiple diseases, including myxoid liposarcoma and amyotrophic ..
- FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved intronsTadashi Nakaya
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
RNA 19:498-509. 2013Dominant mutations and mislocalization or aggregation of Fused in Sarcoma (FUS), an RNA-binding protein (RBP), cause neuronal degeneration in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD), two incurable ..
- Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease modelsArnaud Tauffenberger
CRCHUM, Universite de Montre al, Montreal, Quebec, Canada
Hum Mol Genet 22:782-94. 2013The DNA/RNA binding proteins TAR DNA-binding protein 43 (TDP-43) and fused-in-sarcoma (FUS) are genetically linked to amyotrophic lateral sclerosis and frontotemporal lobar dementia, while the inappropriate cytoplasmic accumulations of ..
- The effect of PRMT1-mediated arginine methylation on the subcellular localization, stress granules, and detergent-insoluble aggregates of FUS/TLSAtsushi Yamaguchi
Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba, Japan
PLoS ONE 7:e49267. 2012Fused in sarcoma/translocated in liposarcoma (FUS/TLS) is one of causative genes for familial amyotrophic lateral sclerosis (ALS)...
- FUS is not dysregulated by the spinal bulbar muscular atrophy androgen receptor polyglutamine repeat expansionPietro Fratta
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK
Neurobiol Aging 34:1516.e17-9. 2013..Mutations in the FUS gene and fused in sarcoma (FUS) protein pathology have now been identified in some amyotrophic lateral sclerosis ..
- Loss of fused in sarcoma (FUS) promotes pathological Tau splicingDenise Orozco
German Center for Neurodegenerative Diseases DZNE, Munich, Germany
EMBO Rep 13:759-64. 2012..FTLD) patients present pathological redistribution and aggregation of the nuclear protein fused in sarcoma (FUS) in the cytoplasm...
- FUS-related proteinopathies: lessons from animal modelsNicholas A Lanson
Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112 2223, USA
Brain Res 1462:44-60. 2012The recent identification of ALS-linked mutations in FUS and TDP-43 has led to a major shift in our thinking in regard to the potential molecular mechanisms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (..
- Fused in sarcoma (FUS) interacts with the cytolinker protein plectin: implications for FUS subcellular localization and functionChrister Thomsen
Sahlgrenska Cancer Center, Department of Pathology, Sahlgrenska Academy at the University of Gothenburg, Box 425, 40530, Gothenburg, Sweden
Exp Cell Res 318:653-61. 2012Fused in sarcoma (FUS) is a multifunctional protein involved in transcriptional control, pre-mRNA processing, RNA transport and translation...
- Nuclear localization sequence of FUS and induction of stress granules by ALS mutantsJozsef Gal
Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
Neurobiol Aging 32:2323.e27-40. 2011Mutations in fused in sarcoma (FUS) have been reported to cause a subset of familial amyotrophic lateral sclerosis (ALS) cases...
- Characterization of TFG in mus musculus and Caenorhabditis elegansM Mencinger
Department of Clinical Genetics, University Hospital, Lund, S 221 85, Sweden
Biochem Biophys Res Commun 257:67-73. 1999..In situ hybridization with a TFG probe in 10, 5-day whole mouse embryos showed preferential staining of the limb buds, branchial arches, nasal processes, and brain, and weak staining of the primitive spinal cord and dorsal root ganglia...
- Induction of a secreted protein by the myxoid liposarcoma oncogeneM Kuroda
Skirball Institute of Biomolecular Medicine, Departments of Medicine, Cell Biology, and the Kaplan Cancer Center, New York University Medical Center, New York, NY 10016, USA
Proc Natl Acad Sci U S A 96:5025-30. 1999The TLS-CHOP oncoprotein, found in the majority of human myxoid liposarcomas, consists of a fusion between the transcription factor CHOP/GADD153 and the N terminus of an RNA-binding protein TLS/FUS...
- Characterization of a new brain-specific isoform of the EWS oncoproteinT Melot
Laboratoire de Pathologie Moléculaire des Cancers, INSERM U509, Paris, France
Eur J Biochem 268:3483-9. 2001EWS and related TAFII68 and TLS/FUS genes are fused with different genes encoding transcription factors in various human cancers...
- Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesisSylvia R Alappat
Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, USA
Dev Dyn 228:59-71. 2003..These data suggest that mouse Pigpen may activate transcription in vivo in response to specific growth factor signals and regulate proliferation and/or differentiation events during mouse organogenesis...
- System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clockBenoît Kornmann
Department of Molecular Biology, University of Geneva, Geneva, Switzerland
PLoS Biol 5:e34. 2007..The finding that rhythmic mPer2 expression can be driven by both systemic cues and local oscillators suggests a plausible mechanism for the phase entrainment of subsidiary clocks in peripheral organs...
- IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cellsLuisa Cironi
Division of Experimental Pathology, Institute of Pathology CHUV, University of Lausanne, Lausanne, Switzerland
PLoS ONE 3:e2634. 2008..of Ewing's sarcoma family tumors (ESFT), the remaining 10-15% of cases expressing chimeric genes encoding EWS or FUS fused to one of several ets transcription factor family members, including ERG-1, FEV, ETV1 and ETV6...
- Pigpen, a nuclear coiled body component protein, is involved in angiogenesisTomoko Yoshida
Department of Nanomedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Cancer Sci 101:1170-6. 2010..These data indicate that Pigpen is involved in angiogenesis and that pigpen may be a target for blocking tumor angiogenesis...
- FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cellsTakeaki Sugawara
Department of Cellular and Molecular Medicine, Chiba University, Japan
Exp Hematol 38:696-706. 2010b>Fus is the gene for a member of the FET family of RNA-binding proteins often involved in chromosomal translocations to generate oncogenic fusion genes in human cancers...
- Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetimeCao Huang
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Int J Biol Sci 6:396-406. 2010TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) are two highly conserved ribonucleoproteins...
- FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cellsRene Rodriguez
Andalusian Stem Cell Bank, Centro de Investigacion Biomedica, Consejería de Salud Universidad de Granada, Granada, Spain
Stem Cells 29:179-92. 2011..We attempted to develop a model of liposarcoma by expressing FUS (FUsed in Sarcoma; also termed TLS, Translocated in LipoSarcoma)-CHOP (C/EBP HOmologous Protein; also termed DDIT3, DNA Damage-Inducible Transcript 3), a hallmark ..
- TLS and TLS Fusion Proteins in LeukemiaLiu Yang; Fiscal Year: 2005..myelogenous leukemia (AMIL), chronic myelogenous leukemia (CML) in blast crisis, and myelodysplastic syndromes, the TLS (translocation liposarcoma) gene is fused to the ERG (ets-related gene) gene through a recurrent t(16;21) ..
- CHONDROGENESIS AND HISTONE MODIFICATION ENZYMESLiu Yang; Fiscal Year: 2007....