Foxp3

Summary

Gene Symbol: Foxp3
Description: forkhead box P3
Alias: JM2, scurfin, forkhead box protein P3, scurfy
Species: mouse

Top Publications

  1. ncbi Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 4:330-6. 2003
  2. ncbi Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    Estelle Bettelli
    Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 441:235-8. 2006
  3. pmc Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    Angela M Thornton
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:3433-41. 2010
  4. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
  5. doi Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    Yuri P Rubtsov
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 28:546-58. 2008
  6. pmc The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    Meghan A Koch
    Benaroya Research Institute, Seattle, Washington, USA
    Nat Immunol 10:595-602. 2009
  7. pmc Stability of the regulatory T cell lineage in vivo
    Yuri P Rubtsov
    Howard Hughes Medical Institute and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 329:1667-71. 2010
  8. pmc Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    Eric V Dang
    Immunology and Hematopoiesis Division, Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Maryland 21231, USA
    Cell 146:772-84. 2011
  9. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
  10. pmc Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:12204-9. 2010

Research Grants

Detail Information

Publications216 found, 100 shown here

  1. ncbi Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 4:330-6. 2003
    ..The lethal autoimmune syndrome observed in Foxp3-mutant scurfy mice and Foxp3-null mice results from a CD4+CD25+ regulatory T cell deficiency and not from a cell-intrinsic ..
  2. ncbi Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    Estelle Bettelli
    Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 441:235-8. 2006
    ..In contrast, CD4+CD25+Foxp3+ regulatory T (T(reg)) cells inhibit autoimmunity and protect against tissue injury...
  3. pmc Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    Angela M Thornton
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:3433-41. 2010
    ..Although Helios was expressed by 100% of CD4(+)CD8(-)Foxp3(+) thymocytes, its expression in peripheral lymphoid tissues was restricted to a subpopulation ( approximately 70%)..
  4. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
    b>Foxp3(+) regulatory T (T reg) cells play a key role in controlling immune pathological re actions...
  5. doi Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    Yuri P Rubtsov
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 28:546-58. 2008
    ..responses through suppressor-function elaboration that is dependent upon expression of the transcription factor Foxp3. Despite a critical role for Treg cells in maintaining lympho-myeloid homeostasis, it remains unclear whether a ..
  6. pmc The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    Meghan A Koch
    Benaroya Research Institute, Seattle, Washington, USA
    Nat Immunol 10:595-602. 2009
    Several subsets of Foxp3(+) regulatory T cells (T(reg) cells) work in concert to maintain immune homeostasis. However, the molecular bases underlying the phenotypic and functional diversity of T(reg) cells remain obscure...
  7. pmc Stability of the regulatory T cell lineage in vivo
    Yuri P Rubtsov
    Howard Hughes Medical Institute and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 329:1667-71. 2010
    ..Our results suggest that self-renewal of mature T(reg) cells serves as a major mechanism of maintenance of the T(reg) cell lineage in adult mice...
  8. pmc Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    Eric V Dang
    Immunology and Hematopoiesis Division, Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Maryland 21231, USA
    Cell 146:772-84. 2011
    ..Concurrently, HIF-1 attenuates T(reg) development by binding Foxp3 and targeting it for proteasomal degradation...
  9. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
    ..In this regard, the gut is home to a large number of regulatory T (T reg) cells, including the Foxp3(+) T reg cell...
  10. pmc Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:12204-9. 2010
    ..We report herein that a prominent human commensal, Bacteroides fragilis, directs the development of Foxp3(+) regulatory T cells (Tregs) with a unique "inducible" genetic signature...
  11. pmc Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    Yeonseok Chung
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 30:576-87. 2009
    ..Our data thus indicate a critical role of IL-1 in Th17 cell differentiation and this pathway may serve as a unique target for Th17 cell-mediated immunopathology...
  12. ncbi The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 450:566-9. 2007
    ..encodes IL-27beta) and interleukin-12 alpha (Il12a, which encodes IL-12alpha/p35) are highly expressed by mouse Foxp3+ (forkhead box P3) T(reg) cells but not by resting or activated effector CD4+ T (T(eff)) cells, and that an Ebi3-..
  13. pmc Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    Ye Zheng
    Howard Hughes Medical Institute and Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 463:808-12. 2010
    ..cell subset is comprised of cells that commit to the T(reg) lineage by upregulating the transcription factor Foxp3 either in the thymus (tT(reg)) or in the periphery (iT(reg))...
  14. pmc Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
    Katharina Lahl
    Institut fur Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universitat Munchen, 81675 Munich, Germany
    J Exp Med 204:57-63. 2007
    The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3-4 wk of age...
  15. pmc CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    Ashutosh Chaudhry
    Howard Hughes Medical Institute and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 326:986-91. 2009
    ..These findings suggest that T(regs) adapt to their environment by engaging distinct effector response-specific suppression modalities upon activation of STAT proteins that direct the corresponding class of the immune response...
  16. doi Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, RIKEN, Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Science 323:1488-92. 2009
    ..The nature of these T(FH) cells in Peyer's patches has been elusive. Here, we demonstrate that suppressive Foxp3+CD4+ T cells can differentiate into TFH cells in mouse Peyer's patches...
  17. pmc Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
    Mahesh Yadav
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94122, USA
    J Exp Med 209:1713-22, S1-19. 2012
    b>Foxp3(+) CD4(+) T helper cells called regulatory T (T reg) cells play a key role in controlling reactivity to self-antigens and onset of autoimmunity...
  18. pmc Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
    Guillaume Oldenhove
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 31:772-86. 2009
    ..These data reveal a mechanism for Th1 cell pathogenicity that extends beyond their proinflammatory program to limit Treg cell survival...
  19. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
    ..but depends on distinct transcription factors: RORgammat (encoded by Rorc(gammat)) for T(H)17 cells and Foxp3 for T(reg) cells...
  20. pmc Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
    Jonathan M Weiss
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 209:1723-42, S1. 2012
    b>Foxp3 activity is essential for the normal function of the immune system. Two types of regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells...
  21. ncbi Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    Jason D Fontenot
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Immunity 22:329-41. 2005
    ..Here, we present data arguing that the forkhead transcription factor Foxp3 acts as the regulatory T cell lineage specification factor and mediator of the genetic mechanism of dominant ..
  22. ncbi An essential role for Scurfin in CD4+CD25+ T regulatory cells
    Roli Khattri
    Celltech R and D Inc, 1631 220th Street SE, Bothell, Washington 98021, USA
    Nat Immunol 4:337-42. 2003
    ..Absence of the transcription factor Scurfin (also known as forkhead box P3 and encoded by Foxp3) causes a rapidly fatal lymphoproliferative disease, similar ..
  23. pmc IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    Thomas Korn
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 448:484-7. 2007
    ..of T(H)17 cells, in which IL-6 has a pivotal function in dictating whether T cells differentiate into Foxp3+ regulatory T cells (T(reg) cells) or T(H)17 cells...
  24. doi Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation
    Maria A Curotto de Lafaille
    Program of Molecular Pathogenesis, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Immunity 29:114-26. 2008
    Adaptive Foxp3(+) regulatory T (Treg) cells develop during induction of mucosal tolerance and after immunization. Large numbers of Foxp3(+) T cells have been found in inflamed tissues...
  25. pmc Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells
    Li Wang
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Proc Natl Acad Sci U S A 105:9331-6. 2008
    ..study, we show that ex vivo splenic DCs are capable of inducing conversion of naïve CD4(+) T cells to adaptive Foxp3(+)CD4(+) regulatory T cells (aTreg) in the presence of TGF-beta...
  26. doi Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 453:65-71. 2008
    Regulatory T cells (T(reg)) expressing the transcription factor Foxp3 control the autoreactive components of the immune system...
  27. pmc Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells
    Michael G Strainic
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Nat Immunol 14:162-71. 2013
    ..increased, autoinductive signaling by transforming growth factor-β1 (TGF-β1) initiated and CD4(+) T cells became Foxp3(+) induced regulatory T cells (iT(reg) cells)...
  28. pmc The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
    Guangwei Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1047-56. 2010
    ..Here we found that the differentiation of proinflammatory T helper type 1 (T(H)1) cells and anti-inflammatory Foxp3(+) regulatory T cells (T(reg) cells) was reciprocally regulated by S1P(1), a receptor for the bioactive lipid ..
  29. pmc Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation
    Ilona Gutcher
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 34:396-408. 2011
    ..These findings reveal an essential role for activated T cell-produced TGF-β1 in promoting the differentiation of Th17 cells and controlling inflammatory diseases...
  30. ncbi Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10
    Craig L Maynard
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 8:931-41. 2007
    ..We generated mice with a 'dual-reporter' system of the genes encoding IL-10 and the transcription factor Foxp3 to track T(reg) subsets based on coordinate or differential expression of these genes...
  31. ncbi X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    R S Wildin
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland, USA
    Nat Genet 27:18-20. 2001
    ..We found four non-polymorphic mutations. Each mutation affects the forkhead/winged-helix domain of the scurfin protein, indicating that the mutations may disrupt critical DNA interactions.
  32. pmc Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    Julia K Polansky
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124, Braunschweig, Germany
    J Mol Med (Berl) 88:1029-40. 2010
    The forkhead-box protein P3 (Foxp3) is a key transcription factor for the development and suppressive activity of regulatory T cells (Tregs), a T cell subset critically involved in the maintenance of self-tolerance and prevention of over-..
  33. doi The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
    Erika Cretney
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 12:304-11. 2011
    ..Thus, our study defines a differentiation pathway that leads to the acquisition of T(reg) cell effector functions and requires both IRF4 and Blimp-1...
  34. doi The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut
    Shimpei Kawamoto
    Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama, Tsurumi, Yokohama, Japan
    Science 336:485-9. 2012
    ..Thus, PD-1 plays a critical role in regulation of antibody diversification required for the maintenance of intact mucosal barrier...
  35. pmc Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    Ruka Setoguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 201:723-35. 2005
    ..Such treatment selectively reduces the number of Foxp3-expressing CD25(+) CD4(+) T cells, but not CD25(-) CD4(+) T cells, in the thymus and periphery of normal and ..
  36. pmc Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis
    Ana Izcue
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Immunity 28:559-70. 2008
    ..The frequency of naive T cell-derived Foxp3+ cells in the colon increased in the absence of IL-23, indicating a role for IL-23 in controlling regulatory T ..
  37. pmc Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    Masako Murai
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1178-84. 2009
    Regulatory T cells (T(reg) cells) that express the transcription factor Foxp3 suppress the activity of other cells...
  38. doi Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    Jorg van Loosdregt
    Molecular Immunology Lab, Department of Immunology, Wilhelmina Children s Hospital, Utrecht, The Netherlands
    Blood 115:965-74. 2010
    ..Expression levels of the transcription factor Foxp3 have been causally associated with Treg differentiation and function...
  39. ncbi A function for interleukin 2 in Foxp3-expressing regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1142-51. 2005
    Regulatory T cells (T(reg) cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant immune tolerance to self...
  40. ncbi Foxp3-dependent programme of regulatory T-cell differentiation
    Marc A Gavin
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 445:771-5. 2007
    ..CD4+ T cells (Tr cells), the development of which is critically dependent on X-linked transcription factor Foxp3 (forkhead box P3), prevent self-destructive immune responses...
  41. pmc T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
    Stephan Sauer
    Lymphocyte Development Group, Medical Research Council Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom
    Proc Natl Acad Sci U S A 105:7797-802. 2008
    ..fate are not completely understood, we have delineated signaling events that control the de novo expression of Foxp3 in naive peripheral CD4 T cells and in thymocytes...
  42. ncbi Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
    Masahito Kamanaka
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:941-52. 2006
    ..These findings highlight the intestine as a unique site for induction of IL-10-producing T cells, which play a critical role in the regulation of inflammation in the gut...
  43. ncbi Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides
    Wenhui Wu
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA
    Eur J Immunol 36:3238-47. 2006
    ..of dermal dendritic cells and increased IL-6 production, as well as in a reduction in the accumulation of Foxp3(+)CD4(+)CD25(+) regulatory T (T(reg)) cells that naturally occurs in the skin following Leishmania infection...
  44. pmc Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3
    Kian Peng Koh
    Department of Pathology, Harvard Medical School and Immune Disease Institute, Boston, Massachusetts, United States of America
    PLoS ONE 4:e8109. 2009
    The forkhead, winged-helix transcription factor FOXP3 is preferentially expressed in T regulatory (Treg) cells and is critical for their immunosuppressive function...
  45. pmc Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs
    Shipra Gupta
    Harvard Medical School, Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Clin Invest 122:2395-404. 2012
    ..We report herein the presence of a galectin-9-sensitive CD4+FoxP3+TIM-3+ population of T cells, which arose from CD4+FoxP3+TIM-3- proliferating T cells in vitro and in vivo and ..
  46. pmc TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice
    Eva N Huter
    Laboratory of Immunology, Cellular Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Immunol 38:1814-21. 2008
    b>Scurfy mice have a deletion in the forkhead domain of the forkhead transcription factor p3 (Foxp3), fail to develop thymic-derived, naturally occurring Foxp3+ regulatory T cells (nTreg), and develop a fatal lymphoproliferative syndrome ..
  47. doi Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    Meixiao Long
    Department of Immunobiology and Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 31:921-31. 2009
    Naturally derived regulatory T (Treg) cells are characterized by stable expression of the transcription factor Foxp3 and characteristic epigenetic imprinting at the Foxp3 gene locus...
  48. pmc Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia
    Elena Maganto-Garcia
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, NRB 7, Boston, MA 02115, USA
    Circulation 124:185-95. 2011
    ..Regulatory T cells (Treg) are present in atherosclerotic lesions and can modulate disease. In this study we characterized changes in Treg responses associated with prolonged hypercholesterolemia and lesion progression...
  49. pmc The plasticity of regulatory T cell function
    Meenu R Pillai
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Immunol 187:4987-97. 2011
    ..These data reveal that cross-regulatory pathways exist that control the utilization of suppressive mechanisms, thereby providing T(reg) functional plasticity...
  50. pmc Enhancement of antigen-specific Treg vaccination in vivo
    Carolin Daniel
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:16246-51. 2010
    ..The resulting Tregs exhibit increased stability of Foxp3 expression even when generated in TGFβ-containing media in vitro...
  51. ncbi TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells
    Song Guo Zheng
    Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    J Immunol 176:3321-9. 2006
    ..TGF-beta could not induce CD4+CD25- cells from CTLA-4(-/-) mice to express normal levels of FoxP3 or to develop suppressor activity...
  52. ncbi Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    Jeong M Kim
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 8:191-7. 2007
    Mice lacking the transcription factor Foxp3 (Foxp3(-)) lack regulatory T (T(reg)) cells and develop fatal autoimmune pathology...
  53. ncbi Regulatory T cell development in the absence of functional Foxp3
    Wen Lin
    Division of Immunology, Allergy and Rheumatology, Department of Pediatrics, The David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, California 90095, USA
    Nat Immunol 8:359-68. 2007
    ..the development of regulatory T cells (T(reg) cells) in the thymus is defined by expression of the lineage marker Foxp3, the precise function of Foxp3 in T(reg) cell lineage commitment is unknown...
  54. ncbi IL-27 inhibits the development of regulatory T cells via STAT3
    Magdalena Huber
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Marburg, Hans Meerwein Strasse 2, 35043 Marburg, Germany
    Int Immunol 20:223-34. 2008
    ..properties, to regulate the generation of transforming growth factor beta (TGFbeta)-inducible forkhead box P3 (Foxp3)-positive regulatory T (Treg) cells...
  55. doi Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment
    Lee Kim Swee
    Departement Biomedizin Basel, University of Basel, Switzerland
    Blood 113:6277-87. 2009
    ..It also reinforces the relevance of FLT3L treatment in GVHD by its ability to increase both the number of tolerizing DCs and NTregs...
  56. pmc IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation
    Christoph Bucher
    University of Minnesota Cancer Center and Department of Pediatrics, Division of BMT, Minneapolis, MN, USA
    Blood 114:5375-84. 2009
    ..b>FoxP3(+) Tregs were increased in colons of anti-IL-21 Ab-treated recipients of FoxP3(-) IL-21(-/-) T cells, indicating ..
  57. doi 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis
    Christopher G Mayne
    Division of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53706, USA
    Eur J Immunol 41:822-32. 2011
    ..Neither 1,25-(OH)(2) D(3) nor T-cell-specific VDR targeting influenced CD4(+) Foxp3(+) T-cell proportions in the periphery or the CNS in these studies...
  58. pmc Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines
    Jens Nolting
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:2131-9. 2009
    ..Interleukin (IL)-6 strongly reduced RAR alpha expression levels such that a deficiency of the predominant RAR alpha 1 isoform leaves too little RAR alpha 2 for RA to inhibit the generation of Th17 cells in the presence of IL-6...
  59. pmc c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
    Iwao Isomura
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 206:3001-14. 2009
    ..Although Foxp3 maintains a pattern of gene expression necessary for T reg cell function, other transcription factors are emerging ..
  60. pmc IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 9:1347-55. 2008
    Transcription factor Foxp3 is critical for generating regulatory T cells (T(reg) cells)...
  61. pmc Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, Rockefeller University, New York, NY 10021 6399, USA
    Blood 110:4293-302. 2007
    b>Foxp3(+)CD25(+)CD4(+) regulatory T cells are produced in the thymus (natural T regs) but can also differentiate from peripheral Foxp3(-)CD4(+) precursors (induced or adaptive T regs)...
  62. ncbi Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
    Yukiko Tone
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 9:194-202. 2008
    The transcription factor Foxp3 is involved in the differentiation, function and survival of CD4+CD25+ regulatory T (T(reg)) cells...
  63. pmc CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells
    Luciana L Molinero
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 182:6736-43. 2009
    ..These data suggest a modified model of nTreg development in which TCR-CBM-dependent signals are essential to commit immature thymocytes to the nTreg lineage...
  64. pmc Normalization of obesity-associated insulin resistance through immunotherapy
    Shawn Winer
    Department of Pediatrics and Immunology, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Nat Med 15:921-9. 2009
    ..overwhelming static numbers of T(H)2 (CD4(+)GATA-binding protein-3 (GATA-3)(+)) and regulatory forkhead box P3 (Foxp3)(+) T cells...
  65. ncbi Deacetylase inhibition promotes the generation and function of regulatory T cells
    Ran Tao
    Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Studies of Pediatric Liver Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Nat Med 13:1299-307. 2007
    ..We found that administration of an HDAC inhibitor (HDACi) in vivo increased Foxp3 gene expression, as well as the production and suppressive function of regulatory T cells (T(reg) cells)...
  66. ncbi Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    Jonathan A Hill
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Immunity 27:786-800. 2007
    ..The transcription factor Foxp3 had been thought to determine the Treg cell lineage, a hypothesis challenged by recent observations...
  67. pmc Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire
    Matthew A Burchill
    Department of Laboratory Medicine and Pathology, Center for Immunology, The Cancer Center, University of Minnesota, 312 Church Street SE, 6 116 Nils Hasselmo Hall, Minneapolis, MN 55455 USA
    Immunity 28:112-21. 2008
    ..Our data support a two-step model of Treg cell differentiation in which TCR and CD28 signals induce cytokine responsiveness and STAT5-inducing cytokines then complete the program of Treg cell differentiation...
  68. pmc The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 9:245-53. 2008
    ..Transforming growth factor-beta (TGF-beta) signaling in naive T cells induces expression of the transcription factor Foxp3, a 'master' regulator of regulatory T cells (T(reg) cells)...
  69. pmc Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells
    Guo Yun Chen
    Division of Immunotherapy, Section of General Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 180:5163-6. 2008
    ..To test the assumption, we used the Rag2(-/-) and the Rag2(-/-) mice with the Scurfy (sf) mutation (FoxP3(sf/Y) or FoxP3(sf/sf)) to evaluate FoxP3 expression outside of the lymphoid system...
  70. doi Role of TGF-Beta in the induction of Foxp3 expression and T regulatory cell function
    Ethan M Shevach
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Heath, Blg 10, Room 11N315, Bethesda, MD 20892, USA
    J Clin Immunol 28:640-6. 2008
    ..Polyclonal TGF-beta-induced Treg (iTreg) are capable of preventing the autoimmune syndrome that develops in scurfy mice that lack Foxp3(+) Treg...
  71. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
    ..Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3...
  72. pmc Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Immunol 182:6121-8. 2009
    ..These data suggest that it is the induction of suppression, rather than the function of T(reg) that is obligatorily contact dependent...
  73. pmc Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 32:642-53. 2010
    ..These findings reveal a critical function for TGF-beta in control of autoreactive T cell fates with important implications for understanding T cell self-tolerance mechanisms...
  74. doi Ras inhibition attenuates pancreatic cell death and experimental type 1 diabetes: possible role of regulatory T cells
    Elizabeta Aizman
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel
    Eur J Pharmacol 643:139-44. 2010
    ..of Treg in such an effect, we evaluated the incidence of diabetes and assayed the pancreatic expression of Foxp3, cleaved caspase 3, and Ras-GTP expression in NOD mice treated with different doses of F-FTS...
  75. pmc The Ets-1 transcription factor controls the development and function of natural regulatory T cells
    Enguerran Mouly
    EA3963, Universite Paris 7 Denis Diderot, Institut National de la Sante et de la Recherche Medicale, Institut Fédératif de Recherche 105, Institut Universitaire d Hematologie, 75475 Paris, France
    J Exp Med 207:2113-25. 2010
    ..The transcription factor Foxp3 is important for determining the development and function of T reg cells; however, the molecular mechanisms that ..
  76. ncbi Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
    Louise M D'Cruz
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    Nat Immunol 6:1152-9. 2005
    ..of an antigen-specific population of regulatory T cells positive for forkhead family transcription factor Foxp3 and have correlated our observations with polyclonal suppressor populations...
  77. pmc CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:285-97. 2007
    ..IL-10 was produced by innate cells, as well as CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(-)Foxp3(-) T cells in the chronic lesion...
  78. ncbi Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    Masahiro Ono
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Nature 446:685-9. 2007
    ..T(R) cells specifically express the transcription factor Foxp3, a key regulator of T(R)-cell development and function...
  79. pmc OX40 costimulation turns off Foxp3+ Tregs
    Minh Diem Vu
    Harvard Medical School, Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 110:2501-10. 2007
    ..OX40 can be expressed by both activated T effector cells and Foxp3(+) Tregs...
  80. pmc Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
    Fuping Zhang
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1297-306. 2008
    ..However, Runx1 also interacts with the transcription factor Foxp3, and this interaction was necessary for the negative effect of Foxp3 on T(H)-17 differentiation...
  81. ncbi Cellular and molecular characterization of the scurfy mouse mutant
    L B Clark
    Chiroscience R and D, Inc, Seattle, WA 98021, USA
    J Immunol 162:2546-54. 1999
    Mice hemizygous (Xsf/Y) for the X-linked mutation scurfy (sf) develop a severe and rapidly fatal lymphoproliferative disease mediated by CD4+CD8- T lymphocytes...
  82. pmc Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cells
    Hiroyoshi Nishikawa
    Second Department of Internal Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    J Exp Med 201:681-6. 2005
    ..The suppressive effect was observed without in vitro T cell stimulation. Foxp3 expression in these CD4(+) CD25(+) T cells from immunized mice was 5-10 times greater than CD4(+) CD25(+) T cells ..
  83. ncbi T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 26:579-91. 2007
    ..TGF-beta1 produced by Foxp3-expressing regulatory T cells was required to inhibit Th1-cell differentiation and inflammatory-bowel disease in a ..
  84. ncbi Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    M E Brunkow
    Celltech Chiroscience, Inc, Bothell, Washington, USA
    Nat Genet 27:68-73. 2001
    ..In sf mice, a frameshift mutation results in a product lacking the forkhead domain. Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis.
  85. ncbi The amount of scurfin protein determines peripheral T cell number and responsiveness
    R Khattri
    Celltech R and D, Inc, Bothell, WA 98021, USA
    J Immunol 167:6312-20. 2001
    In the absence of the recently identified putative transcription factor scurfin, mice develop a lymphoproliferative disorder resulting in death by 3 wk of age from a pathology that resembles TGF-beta or CTLA-4 knockout mice...
  86. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in ..
  87. pmc Control of homeostatic proliferation by regulatory T cells
    Shiqian Shen
    Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Clin Invest 115:3517-26. 2005
    ..The presence of Tregs resulted in a lower accumulation of T cells, enhanced apoptosis, and impaired differentiation to a cytokine-producing state. We conclude that Tregs play a major role in the control of homeostatic proliferation...
  88. ncbi Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7
    Regis Peffault De Latour
    Unité INSERM U 668, Unité du Développement des Lymphocytes, Institut Pasteur, Paris, France
    Blood 108:2300-6. 2006
    ..We show here that the establishment of the peripheral pool of Foxp3-expressing regulatory cells is IL-7 independent, and the premature involution of the thymus in IL-7-/- mice does ..
  89. ncbi Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
    Julien C Marie
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Immunity 25:441-54. 2006
    ..Thus, TGF-beta signaling in peripheral T cells is crucial in restraining TCR activation-dependent Th1, cytotoxic, and NK cell-like differentiation program which, when left unchecked, leads to rapidly progressing fatal autoimmunity...
  90. ncbi Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    Ye Zheng
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 445:936-40. 2007
    Transcription factor Foxp3 (forkhead box P3), restricted in its expression to a specialized regulatory CD4+ T-cell subset (T(R)) with a dedicated suppressor function, controls T(R) lineage development...
  91. pmc Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    Alexander Marson
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 445:931-5. 2007
    b>Foxp3+CD4+CD25+ regulatory T (T(reg)) cells are essential for the prevention of autoimmunity...
  92. pmc Role of CD28 in fatal autoimmune disorder in scurfy mice
    Nagendra Singh
    Immunotherapy Center, Medical College of Georgia, Augusta, USA
    Blood 110:1199-206. 2007
    b>Scurfy mice develop CD4 T-cell-mediated lymphoproliferative disease leading to death within 4 weeks of age...
  93. ncbi CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression
    Ram Pyare Singh
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 1001 Veteran Avenue, Los Angeles, CA 90095, USA
    J Immunol 178:7649-57. 2007
    ..function of CD8+ T cells from tolerized mice is sustained for up to 8 wk and at all times depends on expression of Foxp3. Both CD28-positive and CD28-negative CD8+ T cells contain inhibitory cells, but the expression of mRNA for Foxp3 ..
  94. ncbi Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells
    Richard J DiPaolo
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Immunol 179:4685-93. 2007
    ..In this study, we demonstrate that naive CD4+ Foxp3- T cells specific for a naturally expressed autoantigen (H+/K+ ATPase) can be converted to Foxp3+ T regulatory ..
  95. ncbi CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    Pushpa Pandiyan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 8:1353-62. 2007
    A key issue in mammalian immunology is how CD4+CD25+Foxp3+ regulatory T cells (T(reg) cells) suppress immune responses...
  96. ncbi In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells
    Jian Guo Chai
    Cancer Immunotherapy Group, Department of Immunology, Imperial College London, UK
    J Immunol 180:858-69. 2008
    ..Furthermore, expanded Tregs appeared to express a reduced level of Foxp3, which could be prevented by adding TGFbeta to the culture, and they also tended to lose Foxp3 following the ..
  97. doi FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1
    Sang Myeong Lee
    Department of Otolaryngology Head and Neck Surgery, University of Missouri Columbia School of Medicine 65212, USA
    Blood 111:3599-606. 2008
    ..The forkhead transcription factor, FoxP3, is a key molecule necessary and sufficient for Tregs development and function...
  98. pmc Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK
    Xunrong Luo
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 180:2757-61. 2008
    ..T regulatory cells can be accomplished by TGF-beta through an epigenetic regulation leading to the expression of Foxp3. However, the exact mechanism of such a TGF-beta-mediated action remains unclear...
  99. pmc STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor
    Hiromi Takaki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582
    J Biol Chem 283:14955-62. 2008
    It has been shown that transforming growth factor beta1 (TGF-beta1) is critical in the generation of CD4(+)CD25(+)Foxp3(+)-inducible regulatory T cells (iTregs) from naïve CD4(+)T cells...
  100. pmc A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells
    Allison L Bayer
    Department of Microbiology and Immunology, Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Immunol 181:225-34. 2008
    ..IL-2- and IL-2R-deficient mice are not completely devoid of Foxp3+ cells, but rather lack population of mature CD4+CD25+Foxp3high Treg cells and contain few immature CD4+CD25-..
  101. pmc Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:44-56. 2008
    ..Using IL-17F-RFP together with a Foxp3 reporter, we found that the development of Th17 and Foxp3(+) Treg cells was associated in immune responses...

Research Grants15

  1. IMMUNOPATHOGENESIS OF VIRUS-INDUCED DEMYELINATION
    Stanley Perlman; Fiscal Year: 2003
    ....
  2. The Role of Smads and AR in FSHbeta Gene Expression
    VARYKINA THACKRAY; Fiscal Year: 2005
    ..Specific Aim 2: Characterize the interactions among Smads, AR, and Pbx/Prep homeodomain Proteins. Specific Aim 3: Determine whether Smads and/or AR regulate FSH Beta gene expression in mouse pituitary gonadotropes in vivo. ..
  3. Natural IgM antilymphocyte autoantibodies inhibit HIV-1
    PETER LOBO; Fiscal Year: 2003
    ..A successful outcome with the proposed studies could better our understanding on pathogenesis of H1V-1 infection and may provide strategies to prolong the asymptomatic state after HIV-1 infection. ..
  4. Role of BCL-6 in Allergic Immune Responses
    Alexander Dent; Fiscal Year: 2005
    ..These studies will also provide insight into the function of BCL6, which may help the treatment of B cell lymphoma. ..
  5. MOLECULAR MECHANISMS OF BONE MARROW INDUCED TOLERANCE
    James George; Fiscal Year: 2003
    ..The information generated will provide information regarding the specific cellular and subcellular events that are critical to the induction and maintenance of tolerance in this system. ..
  6. The use of primates for human xenotransplantation
    Joanne Zahorsky Reeves; Fiscal Year: 2004
    ..Mastering of these techniques will allow Dr. Zahorsky-Reeves to become an independent animal-based research not only in the field of xenotransplantation, but, broadly, in a variety of immunological settings. ..
  7. TRANSCRIPTIONAL CONTROL OF TH2 CELL DIFFERENTIATION
    Wei Ping Zheng; Fiscal Year: 2004
    ..It is proposed that knowledge gained from these studies will advance understanding and improve treatment of immunological diseases such as allergy and infection where Th2 responses are critical. ..
  8. Organ-specific migration of CD4+CD25+ regulatory T cells
    Chang Kim; Fiscal Year: 2006
    ..These studies have the potential to provide important information on organ or tissue-specific trafficking of CD4+CD25+ suppressor T cells and its impact on immune tolerance. ..
  9. Immunosuppression and regulatory T cells in aging
    Claire Chougnet; Fiscal Year: 2006
    ..abstract_text> ..
  10. The antigen specificity of CD25+ CD4+ T regulatory cells
    CHYI HSIEH; Fiscal Year: 2005
    ..Understanding the antigen specificity of this important endogenous T cell suppressor may facilitate the development of disease specific treatments without broad immuno-suppressive side effects. ..
  11. Immune Response for Hemophilia After Replacement Therapy
    CAROL MIAO; Fiscal Year: 2008
    ..Furthermore, Foxp3 which encodes the transcription factor Scurfin, is a master regulatory gene for the development and function of CD4+CD25+ regulatory T cells...
  12. CD40 Ligand Dysregulation and HIV Pathogenesis
    Claire Chougnet; Fiscal Year: 2009
    ..abstract_text> ..
  13. Basal Ig Signaling and Receptor Editing
    Michael Farrar; Fiscal Year: 2009
    ..abstract_text> ..
  14. Nonviral Gene Medicine for Hemophilia A
    Carol H Miao; Fiscal Year: 2010
    ..abstract_text> ..
  15. Role of Regulatory T Cells in HIV Infection
    Claire A Chougnet; Fiscal Year: 2010
    ....