Foxo1

Summary

Gene Symbol: Foxo1
Description: forkhead box O1
Alias: AI876417, Afxh, FKHR, Fkhr1, Foxo1a, forkhead box protein O1, forkhead box O1a, forkhead box protein O1A, forkhead in rhabdomyosarcoma, forkhead protein 1
Species: mouse

Top Publications

  1. pmc FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
    Ji Hye Paik
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Cell 128:309-23. 2007
  2. ncbi Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
    J Nakae
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:15982-5. 1999
  3. pmc A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
    Tadahiro Kitamura
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:2477-85. 2007
  4. pmc The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    Tadahiro Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    J Clin Invest 110:1839-47. 2002
  5. ncbi FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    Yukari Ido Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, Columbia University, New York, New York 10032, USA
    Cell Metab 2:153-63. 2005
  6. pmc Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
    Hart S Dengler
    Program of Inflammatory Disease Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Nat Immunol 9:1388-98. 2008
  7. ncbi Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass
    Naoko Hashimoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Genet 38:589-93. 2006
  8. ncbi Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    Jun Nakae
    Naomi Berrie Diabetes Center, Berrie Research Pavilion, 1150 St Nicholas Avenue, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nat Genet 32:245-53. 2002
  9. doi A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding
    Keiko Hirota
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 283:32432-41. 2008
  10. pmc FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages
    Dongming Su
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 58:2624-33. 2009

Research Grants

  1. The Role of Smads and AR in FSHbeta Gene Expression
    VARYKINA THACKRAY; Fiscal Year: 2005
  2. Conference on Muscle: Excitation-Contraction Coupling
    Martin Schneider; Fiscal Year: 2003
  3. Local Ca2+ signaling in sympathetic ganglion neurons
    Martin Schneider; Fiscal Year: 2005
  4. Activity Dependent Signaling in Muscle Fiber Plasticity
    Martin Schneider; Fiscal Year: 2007
  5. MOUSE MODELS OF INSULIN RESISTANCE
    Domenico Accili; Fiscal Year: 2009
  6. CONTROL OF CALCIUM RELEASE IN SKELETAL MUSCLE FIBERS
    Martin Schneider; Fiscal Year: 2006
  7. Convergence of Nuclear Receptor and Forkhead Signaling
    Paul Dowell; Fiscal Year: 2004
  8. Relationship of Apo B and BHMT: Nutrition and Physiology
    Janet Sparks; Fiscal Year: 2004
  9. Ovarian Follicular Developmental and Hormone Action
    Joanne Richards; Fiscal Year: 2007
  10. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications158 found, 100 shown here

  1. pmc FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
    Ji Hye Paik
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Cell 128:309-23. 2007
    ..The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting genetic analysis of the ..
  2. ncbi Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
    J Nakae
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:15982-5. 1999
    ..Daf-16 encodes a forkhead transcription factor. Based on sequence similarity, the FKHR genes are the likeliest mammalian Daf-16 homologues...
  3. pmc A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
    Tadahiro Kitamura
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:2477-85. 2007
    ..Inhibition of myoblast differentiation by constitutively active Foxo1 is partly rescued by inhibition of Notch signaling while Foxo1 loss of function precludes Notch inhibition of ..
  4. pmc The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    Tadahiro Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    J Clin Invest 110:1839-47. 2002
    ..We report that haploinsufficiency for the forkhead transcription factor Foxo1 reverses beta cell failure in Irs2(-/-) mice through partial restoration of beta cell proliferation and increased ..
  5. ncbi FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    Yukari Ido Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, Columbia University, New York, New York 10032, USA
    Cell Metab 2:153-63. 2005
    ..We show that the forkhead protein FoxO1 protects beta cells against oxidative stress by forming a complex with the promyelocytic leukemia protein Pml and ..
  6. pmc Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
    Hart S Dengler
    Program of Inflammatory Disease Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Nat Immunol 9:1388-98. 2008
    The transcription factors Foxo1, Foxo3 and Foxo4 modulate cell fate 'decisions' in diverse systems. Here we show that Foxo1-dependent gene expression was critical at many stages of B cell differentiation...
  7. ncbi Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass
    Naoko Hashimoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Genet 38:589-93. 2006
    ..Haploinsufficiency of the gene for the transcription factor Foxo1 resulted in a marked increase in the number, but not the size, of cells and resulted in the restoration of glucose ..
  8. ncbi Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    Jun Nakae
    Naomi Berrie Diabetes Center, Berrie Research Pavilion, 1150 St Nicholas Avenue, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nat Genet 32:245-53. 2002
    ..It is not known whether the two defects share a common pathogenesis. We show that haploinsufficiency of the Foxo1 gene, encoding a forkhead transcription factor (forkhead box transcription factor O1), restores insulin ..
  9. doi A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding
    Keiko Hirota
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 283:32432-41. 2008
    ..transcriptional regulation of these genes by nutritional condition and found that reciprocal function of HNF-4 and Foxo1 plays an important role in this process...
  10. pmc FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages
    Dongming Su
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 58:2624-33. 2009
    ..Our goal is to decipher the molecular linkage between proinflammatory cytokine production and insulin resistance in macrophages...
  11. pmc Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia
    Rebecca A Haeusler
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 285:26861-8. 2010
    ..Transcription factor FoxO1 is regulated dually by insulin and nutrients...
  12. pmc Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
    Utpal B Pajvani
    Department of Medicine, Columbia University, New York, New York, USA
    Nat Med 17:961-7. 2011
    Transcription factor FoxO1 promotes hepatic glucose production. Genetic inhibition of FoxO1 function prevents diabetes in experimental animal models, providing impetus to identify pharmacological approaches to modulate this function...
  13. pmc Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    W H Biggs
    The Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 96:7421-6. 1999
    ..by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors...
  14. ncbi Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway
    Yongheng Cao
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 281:40242-51. 2006
    Both TSC2 (tuberin) and forkhead transcription factor FoxO1 are phosphorylated and inhibited by Akt and play important roles in insulin signaling. However, little is known about the relationship between TSC2 and FoxO1...
  15. doi Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors
    Heather J Evans-Anderson
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Circ Res 102:686-94. 2008
    ..Here, we show that FOXO1 and FOXO3 are expressed in the developing myocardium concomitant with increased cyclin kinase inhibitor expression ..
  16. pmc FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue
    Jane J Kim
    Department of Pediatrics, University of California at San Diego, La Jolla, California, USA
    Diabetes 58:1275-82. 2009
    ..Although the FoxO1 isoform is known to play a key role in adipogenesis, its physiological role in differentiated adipose tissue ..
  17. pmc FoxOs function synergistically to promote glucose production
    Rebecca A Haeusler
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 285:35245-8. 2010
    ..production (HGP) plays a vital role in maintaining the supply of glucose to the body, and transcription factor FoxO1 is known to confer hormone responsiveness onto HGP...
  18. pmc Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1
    Tadahiro Kitamura
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 100321, USA
    Mol Cell Biol 29:4417-30. 2009
    ..During embryogenesis, transcription factor FoxO1 is expressed in pancreatic progenitor cells...
  19. pmc MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice
    Zhidan Wu
    Cardiovascular and Metabolism, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
    J Clin Invest 120:3901-11. 2010
    ..In vitro experiments identified forkhead box O1 (FOXO1) as a substrate for MKP-3...
  20. pmc FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis
    Boyi Gan
    Belfer Institute for Applied Cancer Science, Boston, MA 02115, USA
    Cancer Cell 18:472-84. 2010
    ....
  21. pmc FOXO1 transcription factor inhibits luteinizing hormone β gene expression in pituitary gonadotrope cells
    David J Arriola
    Department of Reproductive Medicine and The Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 287:33424-35. 2012
    ..In this study we investigated whether FOXO1 is expressed in gonadotropes and if it can modulate LH β-subunit (Lhb) gene expression...
  22. ncbi Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
    David Frescas
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032
    J Biol Chem 280:20589-95. 2005
    ..Sirtuin activation or hydrogen peroxide treatment overrides the phosphorylation-dependent nuclear exclusion of FoxO1 caused by growth factors and causes nuclear translocation of FoxO1 in hepatocytes...
  23. pmc Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
    Michihiro Matsumoto
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 116:2464-72. 2006
    ..Here we show that adenoviral delivery of constitutively nuclear forkhead box O1 (FoxO1) to mouse liver results in steatosis arising from increased triglyceride accumulation and decreased fatty acid ..
  24. pmc The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
    Jun Nakae
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:2473-83. 2006
    The forkhead transcription factor FoxO1 has been identified as a negative regulator of insulin/IGF-1 signaling. Its function is inhibited by phosphorylation and nuclear exclusion through a PI3K-dependent pathway...
  25. pmc Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
    Yann M Kerdiles
    Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093 0377, USA
    Nat Immunol 10:176-84. 2009
    ..Here we show that Foxo1 has a crucial, nonredundant role in T cells...
  26. pmc FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 284:11110-20. 2009
    The current studies show FGF15 signaling decreases hepatic forkhead transcription factor 1 (FoxO1) activity through phosphatidylinositol (PI) 3-kinase-dependent phosphorylation...
  27. ncbi SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex
    Liping Qiao
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 281:39915-24. 2006
    ..Recent studies have indicated that forkhead transcription factor O1 (Foxo1) and silent information regulator 2 mammalian ortholog SIRT1 are involved in adipogenesis...
  28. ncbi Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
    Michihiro Matsumoto
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 6:208-16. 2007
    ..We show that inactivation of the gene encoding forkhead protein Foxo1 in mouse liver results in 40% reduction of glucose levels at birth and 30% reduction in adult mice after a 48 hr ..
  29. pmc Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis
    Cristina C Teixeira
    Department of Orthodontics, New York University College of Dentistry, New York, New York 10010, USA
    J Biol Chem 285:31055-65. 2010
    ..The pathways that control mesenchymal cell differentiation are not well understood. We propose that Foxo1 is an early molecular regulator during mesenchymal cell differentiation into osteoblasts...
  30. ncbi Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways
    Paul Dowell
    Biological Chemistry and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:45485-91. 2003
    The forkhead factor Foxo1 (or FKHR) was identified in a yeast two-hybrid screen as a peroxisome proliferator-activated receptor (PPAR) gamma-interacting protein...
  31. ncbi FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression
    Wenwei Zhang
    Departments of Medicine and Physiology and Biophysics, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Biol Chem 281:10105-17. 2006
    ..understand the role of FoxO proteins in the liver, we created transgenic mice expressing constitutively active FoxO1 in the liver using the alpha1-antitrypsin promoter...
  32. ncbi Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice
    Tatsuo Furuyama
    Department of Molecular Genetics and Geriatric Research, National Institute for Longevity Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    J Biol Chem 279:34741-9. 2004
    Members of the Foxo family, Foxo1 (Fkhr), Foxo3 (Fkhrl1), and Foxo4 (Afx), are mammalian homologs of daf-16, which influences life span and energy metabolism in Caenorhabditis elegans...
  33. doi PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response
    Bengt F Belgardt
    Institute for Genetics, Department of Mouse Genetics and Metabolism, Center for Molecular Medicine Cologne CMMC, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 7:291-301. 2008
    ..Expression of a dominant-negative mutant of FOXO1 specifically in POMC cells is sufficient to ameliorate positive energy balance in PDK1(DeltaPOMC) mice but cannot ..
  34. pmc Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress
    Takafumi Senokuchi
    Department of Medicine, Columbia University, New York, New York, USA
    Diabetes 57:2967-76. 2008
    ..However, the molecular mechanisms of increased apoptosis in insulin-resistant macrophages remain unclear...
  35. doi PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
    ..Forkhead box-containing protein-O1 (FoxO1) is inactivated in a PI(3)K-dependent manner...
  36. ncbi The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    Jun Nakae
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Cell 4:119-29. 2003
    ..The forkhead transcription factor Foxo1 is regulated by insulin via Akt-dependent phosphorylation and nuclear exclusion...
  37. pmc Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 117:399-412. 2004
    ..Thus, forkhead factor(s) play a critical role in the development of muscle atrophy, and inhibition of Foxo factors is an attractive approach to combat muscle wasting...
  38. ncbi Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
    Tadahiro Kitamura
    Department of Medicine, Columbia University Medical Center, 1150 St Nicholas Avenue, New York, New York 10032, USA
    Nat Med 12:534-40. 2006
    ..Here we show that delivery of adenovirus encoding a constitutively nuclear mutant FoxO1, a transcription factor known to control liver metabolism and pancreatic beta-cell function, to the hypothalamic ..
  39. ncbi Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell
    Sara C Martinez
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8127, St Louis, MO 63110, USA
    Diabetes 55:1581-91. 2006
    ..In this study, we tested the hypothesis that glucose regulates Foxo1 activity in the beta-cell via an autocrine/paracrine effect of released insulin on its receptor...
  40. ncbi Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
    Min Seon Kim
    Department of Internal Medicine, University of Ulsan College of Medicine, 138 736 Pungnap dong, Songpa Ku, Seoul 138 736, Korea
    Nat Neurosci 9:901-6. 2006
    ..Studies suggest that the forkhead transcription factor Foxo1 is an important mediator of insulin signaling in peripheral tissues...
  41. pmc FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice
    Adama Kamagate
    Rangos Research Center, Children s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Invest 118:2347-64. 2008
    ..To characterize the underlying mechanism, we studied hepatic MTP regulation by forkhead box O1 (FoxO1), a transcription factor that plays a key role in hepatic insulin signaling...
  42. pmc Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
    T Furuyama
    Laboratory of Genetics of Aging, Department of Molecular Genetic Research, National Institute for Longevity Sciences NILS, 36 3 Gengo, Morioka, Oobu, Aichi 474 8522, Japan
    Biochem J 349:629-34. 2000
    ..Mammalian DAF-16 homologues include AFX, FKHR and FKHRL1, which contain a conserved forkhead domain and three putative phosphorylation sites for the Ser/Thr ..
  43. pmc The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
    J Nakae
    Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 108:1359-67. 2001
    ..The inability to respond to insulin is associated with reduced expression of the forkhead transcription factor Foxo1, a substrate of the Akt kinase that is inhibited by insulin through phosphorylation...
  44. ncbi Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    Pere Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 423:550-5. 2003
    ..Two components known to have important physiological roles in this process are the forkhead transcription factor FOXO1 (also known as FKHR) and peroxisome proliferative activated receptor-gamma co-activator 1 (PGC-1alpha; also known ..
  45. ncbi Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice
    Jennifer Altomonte
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Physiol Endocrinol Metab 285:E718-28. 2003
    ..The forkhead transcription factor Foxo1 has been implicated as a mediator of insulin action in regulating hepatic gluconeogenesis, and a Foxo1 mutant (..
  46. pmc Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    Taisuke Hosaka
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 101:2975-80. 2004
    ..The mammalian orthologs of DAF-16, the closely-related FOXO subclass of forkhead transcription factors (FKHR/FOXO1, FKHRL1/FOXO3a, and AFX/FOXO4), also have important roles in cell cycle arrest, apoptosis and stress responses in ..
  47. ncbi Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors
    Isharat Yusuf
    Department of Molecular Biology and Biochemistry, University of California, Irvine, 92697 3900, USA
    Blood 104:784-7. 2004
    ..Here, we show that B-cell receptor (BCR) engagement triggers PI3K-dependent phosphorylation and nuclear export of FOXO1. Furthermore, forced expression of PI3K-independent variants of FOXO1 or FOXO3a in activated B cells induces ..
  48. ncbi Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
    Yasutomi Kamei
    PRESTO, Japan Science and Technology Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Biol Chem 279:41114-23. 2004
    b>FOXO1, a member of the FOXO forkhead type transcription factors, is markedly up-regulated in skeletal muscle in energy-deprived states such as fasting and severe diabetes, but its functions in skeletal muscle have remained poorly ..
  49. ncbi FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis
    Mani Alikhani
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 280:12096-102. 2005
    ..Fork-head box class-O 1 (FOXO1) was strongly activated, which was confirmed in vitro and in vivo by electrophoretic mobility shift assay...
  50. pmc Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
    Brendan D Manning
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genes Dev 19:1773-8. 2005
    ..However, Pten haploinsufficiency restores Akt signaling in these tumors and dramatically enhances their severity. This study demonstrates that attenuation of the PI3K-Akt pathway in tumors lacking TSC2 contributes to their benign nature...
  51. ncbi Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain
    Marco F M Hoekman
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Gene Expr Patterns 6:134-40. 2006
    ..Here, we focus on three FoxO genes found to be expressed in the brain: FoxO1, FoxO3 and FoxO6...
  52. ncbi FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells
    Caroline M McKinnon
    Henry Wellcome Laboratories for Integrated Cell Signalling and Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, United Kingdom
    J Biol Chem 281:39358-69. 2006
    Forkhead/winged helix box gene, group O-1 (FoxO1) is a member of a family of nuclear transcription factors regulated by insulin-dependent phosphorylation and implicated in the development of the endocrine pancreas...
  53. ncbi Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1
    Sachie Asada
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8577, Japan
    Cell Signal 19:519-27. 2007
    ..b>Foxo1 (FKHR) contains 15 consensus phosphorylation sites for the mitogen-activated protein kinase (MAPK) family...
  54. ncbi B cell receptor signaling down-regulates forkhead box transcription factor class O 1 mRNA expression via phosphatidylinositol 3-kinase and Bruton's tyrosine kinase
    Rochelle M Hinman
    Department of Internal Medicine, Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 178:740-7. 2007
    ..down-regulation of proapoptotic and antimitogenic genes such as forkhead box transcription factor class O 1 (FOXO1) is an important component of this process...
  55. ncbi FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    Zuzana Tothova
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 128:325-39. 2007
    To understand the role of FoxO family members in hematopoiesis, we conditionally deleted FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system...
  56. ncbi Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure
    Jun Nakae
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes 57:563-76. 2008
    ..Forkhead box-containing protein O subfamily (FoxO) 1 mediates insulin action at the transcriptional level. However, physiological roles of FoxO1 in adipose tissue remain unclear.
  57. pmc PP2A regulates the pro-apoptotic activity of FOXO1
    Ling Yan
    Department of Pediatrics, Cancer Biology, The Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 283:7411-20. 2008
    b>FOXO1, a member of the evolutionarily conserved forkhead family of transcription factors, regulates expression of a number of genes that play critical roles in cell cycle and apoptosis...
  58. doi Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons
    Zengqiang Yuan
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 319:1665-8. 2008
    ..We found that Cdk1 phosphorylated the transcription factor FOXO1 at Ser249 in vitro and in vivo...
  59. pmc Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
    Rupesh H Amin
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA
    Nat Immunol 9:613-22. 2008
    ..of the genes encoding RAG-1 and RAG-2 in transformed pro-B cells by a pathway requiring the transcription factor Foxo1. Foxo1 directly activated transcription of the Rag1-Rag2 locus throughout early B cell development, and a decrease ..
  60. pmc Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
    Xiaocheng C Dong
    Howard Hughes Medical Institute, Division of Endocrinology, Children s Hospital Boston, Karp Family Research Laboratories, 300 Longwood Avenue, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 8:65-76. 2008
    The forkhead transcription factor Foxo1 regulates expression of genes involved in stress resistance and metabolism...
  61. pmc Activation of the acquired immune response reduces coupled bone formation in response to a periodontal pathogen
    Yugal Behl
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Immunol 181:8711-8. 2008
    ..The latter was accompanied by an increase in nuclear translocation of the transcription factor FOXO1 in vivo, increased apoptosis of bone-lining cells measured by the TUNEL assay and number of activated caspase-3 ..
  62. pmc An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 30:358-71. 2009
    ..Here we showed that T cell-specific deletion of Foxo1 gene in mice led to spontaneous T cell activation, effector T cell differentiation, autoantibody production, and ..
  63. pmc FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes
    Partha Chakrabarti
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 284:13296-300. 2009
    b>FoxO1 represents a central regulator of metabolism in several cell types. Although FoxO1 is abundant in adipocytes, its biological functions in these cells remain largely unknown...
  64. pmc MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation
    Wei Fu
    Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 284:13987-4000. 2009
    ..We show that MDM2 binds to FOXO1 and FOXO3A and promotes their ubiquitination and degradation, a process apparently dependent on FOXO ..
  65. pmc FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
    Ji Hye Paik
    Department of Medical Oncology, Belfer Institute for Applied Cancer Science, Harvard Medical School, Boston, MA 02115, USA
    Cell Stem Cell 5:540-53. 2009
    ..Here, we report the impact of combined FoxO1, 3, and 4 deficiencies on mammalian brain physiology with a particular emphasis on the study of the neural stem/..
  66. pmc Impaired wound healing in mouse models of diabetes is mediated by TNF-alpha dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1)
    M F Siqueira
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA, USA
    Diabetologia 53:378-88. 2010
    ..The role of TNF-alpha in impaired wound healing in diabetes was examined by focusing on fibroblasts...
  67. pmc FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice
    Elena Ambrogini
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Cell Metab 11:136-46. 2010
    ..Conditional deletion of FoxO1, FoxO3, and FoxO4 in 3-month-old mice resulted in an increase in oxidative stress in bone and osteoblast apoptosis ..
  68. pmc FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts
    Marie Therese Rached
    Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell Metab 11:147-60. 2010
    ..Here we employ cell-specific deletion and molecular analyses to show that, among the three FoxO proteins, only FoxO1 is required for proliferation and redox balance in osteoblasts and thereby controls bone formation...
  69. pmc Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
    Yohsuke Harada
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 207:1381-91. 2010
    ..b>Foxo1 exerts similar effects as Foxo3a on Foxp3 expression...
  70. pmc Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization
    Li Qiang
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 285:27396-401. 2010
    The activity of transcription factor FoxO1 is regulated by phosphorylation-dependent nuclear exclusion and deacetylation-dependent nuclear retention...
  71. pmc A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
    Yin C Lin
    Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA
    Nat Immunol 11:635-43. 2010
    It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus...
  72. pmc Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
    Nirmala Hariharan
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Newark, USA
    Circ Res 107:1470-82. 2010
    ..autophagy, a bulk degradation process of cytosolic proteins and organelles, is protective during nutrient starvation in cardiomyocytes (CMs). However, the underlying signaling mechanism mediating autophagy is not well understood...
  73. pmc FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages
    WuQiang Fan
    Division of Endocrinology Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0673, USA
    EMBO J 29:4223-36. 2010
    ..The transcriptional factor FoxO1 is a key regulator of cell metabolism, cell cycle and cell death...
  74. pmc Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1
    Dan Wei
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA
    Am J Physiol Endocrinol Metab 300:E312-20. 2011
    ..gene), an orphan nuclear receptor, which has been shown to suppress the activity of forkhead transcription factor FoxO1, was decreased in the liver of LKO(Sirt)¹ mice...
  75. pmc FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress
    Arunima Sengupta
    Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children s Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:7468-78. 2011
    ..was investigated in cultured cardiomyocytes and in mice with cardiomyocyte-specific combined deficiency of FoxO1 and FoxO3 subjected to myocardial infarction (MI) or acute ischemia/reperfusion (I/R) injury...
  76. pmc Foxo transcription factors control regulatory T cell development and function
    Yann M Kerdiles
    Molecular Biology Section, Division of Biological Sciences and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093 0377, USA
    Immunity 33:890-904. 2010
    ..Here, we showed the absence of Foxo1 severely curtailed the development of Foxp3(+) regulatory T (Treg) cells and those that developed were ..
  77. pmc Wnt signaling regulates hepatic metabolism
    Hongjun Liu
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 4:ra6. 2011
    ..Furthermore, β-catenin interacted with the transcription factor FoxO1 in livers from mice under starved conditions...
  78. pmc JNK regulates FoxO-dependent autophagy in neurons
    Ping Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 25:310-22. 2011
    ..These data identify JNK as a potent negative regulator of FoxO-dependent autophagy in neurons...
  79. pmc Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
    Maria M Mihaylova
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 145:607-21. 2011
    ..Finally, suppression of class IIa HDACs in mouse models of type 2 diabetes ameliorates hyperglycemia, suggesting that inhibitors of class I/II HDACs may be potential therapeutics for metabolic syndrome...
  80. pmc Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor
    Eva Gonzalez
    Biochemistry Department, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:10162-7. 2011
    ..which translocation of the GLUT4 glucose transporter to the cell surface is blunted yet nuclear exclusion of the FoxO1 transcription factor is preserved, rendering uncoupled insulin-controlled carbohydrate and lipid metabolisms...
  81. pmc AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias
    Stephen M Sykes
    Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 146:697-708. 2011
    ..in human MLL-AF9 leukemia allele-induced AML in mice, where either activation of Akt or compound deletion of FoxO1/3/4 reduced leukemic cell growth, with the latter markedly diminishing leukemia-initiating cell (LIC) function in ..
  82. pmc Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1
    Jonathan Brown
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Biol Chem 286:44295-305. 2011
    ..of mTORC2, plays a critical role in controlling the innate inflammatory response via its ability to regulate FoxO1. Upon LPS stimulation, both rictor-deficient mouse embryonic fibroblasts (MEFs) and rictor knockdown dendritic ..
  83. pmc Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice
    Alexander S Banks
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 14:587-97. 2011
    b>FoxO1 integrates multiple metabolic pathways. Nutrient levels modulate FoxO1 acetylation, but the functional consequences of this posttranslational modification are unclear...
  84. doi Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance
    Hye Jin Kim
    Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371 8512, Japan
    Endocrinology 153:659-71. 2012
    ..of insulin signaling, plays important roles in β-cells and the hypothalamus when we investigated the roles of FoxO1 independently in the pancreas and hypothalamus...
  85. pmc Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia
    Rebecca A Haeusler
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 15:65-74. 2012
    ..Here, we uncover a link between insulin action through FoxO1, bile acid (BA) composition, and altered lipid homeostasis that brings new insight to this longstanding conundrum...
  86. pmc FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis
    Kyoichiro Tsuchiya
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 15:372-81. 2012
    ..The data demonstrate that FoxO inhibition in endothelial cells has the potential to mediate wide-ranging therapeutic benefits for diabetes-associated cardiovascular disease...
  87. pmc FOXO1 in the ventromedial hypothalamus regulates energy balance
    Ki Woo Kim
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center UT Southwestern, Dallas, TX, USA
    J Clin Invest 122:2578-89. 2012
    The transcription factor FOXO1 plays a central role in metabolic homeostasis by regulating leptin and insulin activity in many cell types, including neurons...
  88. pmc Involvement of the up-regulated FoxO1 expression in follicular granulosa cell apoptosis induced by oxidative stress
    Ming Shen
    College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
    J Biol Chem 287:25727-40. 2012
    ..In this study, the involvement of FoxO1 in oxidative stress-induced apoptosis of mouse follicular granulosa cells (MGCs) was investigated in vivo and in ..
  89. pmc Novel Foxo1-dependent transcriptional programs control T(reg) cell function
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 491:554-9. 2012
    ..Here we show that Foxo1 is a pivotal regulator of T(reg )cell function...
  90. pmc FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH
    Zhilin Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 27:238-52. 2013
    The Forkhead boxO (FOXO) transcription factors regulate multiple cellular functions. FOXO1 and FOXO3 are highly expressed in granulosa cells of ovarian follicles...
  91. ncbi The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
    Trevor N Stitt
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Mol Cell 14:395-403. 2004
    ..for this inhibition involves Akt-mediated inhibition of the FoxO family of transcription factors; a mutant form of FOXO1, which prevents Akt phosphorylation, thereby prevents Akt-mediated inhibition of MuRF1 and MAFbx upregulation...
  92. ncbi Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
    Christian Wolfrum
    Laboratory of Metabolic Diseases, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 432:1027-32. 2004
    ..Pharmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes...
  93. ncbi Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action
    Varman T Samuel
    TAC S269, P O Box 9012, 300 Cedar St, Yale University School of Medicine, New Haven, CT 06510, USA
    Diabetes 55:2042-50. 2006
    ..The transcription factor Foxo1 links insulin signaling to decreased transcription of PEPCK and glucose-6-phosphatase (G6Pase) and provides a ..
  94. pmc Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism
    Shen Qu
    Rangos Research Center, Children s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh School of Medicine, 3460 5th Avenue, Room 5140, Pittsburgh, Pennsylvania 15213, USA
    Endocrinology 147:5641-52. 2006
    b>FoxO1 plays an important role in mediating the effect of insulin on hepatic metabolism. Increased FoxO1 activity is associated with reduced ability of insulin to regulate hepatic glucose production...
  95. ncbi The FoxO transcription factors and metabolic regulation
    Jun Nakae
    21st Century COE Program for Signal Transduction Disease, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    FEBS Lett 582:54-67. 2008
    ..The understanding of molecular mechanism how FoxOs affect glucose or lipid metabolism will shed light on the novel therapy of type 2 diabetes and the metabolic syndrome...
  96. pmc TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling
    Jennifer S Moylan
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Am J Physiol Cell Physiol 295:C986-93. 2008
    ..The mechanism involves release of inhibition of Forkhead transcription factors, namely Foxo1 and Foxo3...
  97. pmc Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons
    Hua V Lin
    Department of Medicine, Columbia University, New York, New York, USA
    Diabetes 59:337-46. 2010
    ..We have shown that mice with hypothalamic deficiency (L1) of insulin receptors (InsRs) fail to regulate hepatic glucose production (HGP) in response to insulin...
  98. pmc Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice
    Juhyun Choi
    Department of Biological Sciences, National Research Laboratory of Molecular Genetics, Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
    PLoS ONE 4:e8011. 2009
    ..Mst1 also regulates peripheral naïve T cell trafficking and proliferation in mice. However, its functions in mammals are not fully understood...
  99. pmc FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
    Chia Chen Chen
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Dev Cell 18:592-604. 2010
    ..Here, we unraveled regulatory circuits underlying the interplay between Akt, FoxO, and mTOR. Activated FoxO1 inhibits mTORC1 by TSC2-dependent and TSC2-independent mechanisms...
  100. pmc A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation
    Kyoko Ochiai
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, USA
    Nat Immunol 13:300-7. 2012
    ..Attenuation of IL-7 signaling resulted in upregulation of the transcription factors Foxo1 and Pax5, which coactivated many pre-B cell genes, including Rag1, Rag2 and Blnk...
  101. pmc Generation of functional insulin-producing cells in the gut by Foxo1 ablation
    Chutima Talchai
    Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA
    Nat Genet 44:406-12, S1. 2012
    ..Here, we show that, unexpectedly, somatic ablation of Foxo1 in Neurog3(+) enteroendocrine progenitor cells gives rise to gut insulin-positive (Ins(+)) cells that express ..

Research Grants14

  1. The Role of Smads and AR in FSHbeta Gene Expression
    VARYKINA THACKRAY; Fiscal Year: 2005
    ..Specific Aim 2: Characterize the interactions among Smads, AR, and Pbx/Prep homeodomain Proteins. Specific Aim 3: Determine whether Smads and/or AR regulate FSH Beta gene expression in mouse pituitary gonadotropes in vivo. ..
  2. Conference on Muscle: Excitation-Contraction Coupling
    Martin Schneider; Fiscal Year: 2003
    ..The organizing committee and session leaders will strive to achieve appropriate representation of women, minorities and disabled. All facilities are handicapped accessible. ..
  3. Local Ca2+ signaling in sympathetic ganglion neurons
    Martin Schneider; Fiscal Year: 2005
    ..Our results will provide new insights regarding local Ca2+ signaling mechanisms that could be compromised in neuronal disease. ..
  4. Activity Dependent Signaling in Muscle Fiber Plasticity
    Martin Schneider; Fiscal Year: 2007
    ..The studies proposed here should have important bearing on the effects of use and disuse on muscle fiber gene expression. [unreadable] [unreadable]..
  5. MOUSE MODELS OF INSULIN RESISTANCE
    Domenico Accili; Fiscal Year: 2009
    ..abstract_text> ..
  6. CONTROL OF CALCIUM RELEASE IN SKELETAL MUSCLE FIBERS
    Martin Schneider; Fiscal Year: 2006
    ..The results of these studies should provide further insight into muscle pathological states and to the overall wellness associated with functioning muscle. ..
  7. Convergence of Nuclear Receptor and Forkhead Signaling
    Paul Dowell; Fiscal Year: 2004
    ..Specifically, those pathways mediated by PPARgamma, and Foxo1 in mammals and DAF-12 (worm NHR) and DAF-16 (worm forkhead factor) in C. elegans...
  8. Relationship of Apo B and BHMT: Nutrition and Physiology
    Janet Sparks; Fiscal Year: 2004
    ..A potential link of two pathways whose products or intermediates are associated with increased cardiovascular disease risk could be established. ..
  9. Ovarian Follicular Developmental and Hormone Action
    Joanne Richards; Fiscal Year: 2007
    ..In contrast, FSH like IGF-1 stimulates the phosphorylation of PKB and the down-stream transcription factor Foxo1 or FKHR (forkhead homolog of rhabdomyosarcoma=forkhead)...
  10. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2008
    ..Specific Aim II: Determine the function of AREG target genes that are uniquely expressed at high levels in ovulated COCs (compared to granulosa cells) and that impact ovulation. ..
  11. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ....
  12. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2007
    ..A related and longer term goal of the research is to identify and characterize the genes regulated by LH, prostaglandins (PGs), and C/EBPs that control key steps in the ovulatory process. ..
  13. LRRK2 and cellular pathways of Parkinson's Disease
    Wanli Smith; Fiscal Year: 2007
    ....