Foxn1

Summary

Gene Symbol: Foxn1
Description: forkhead box N1
Alias: D11Bhm185e, Fkh19, HFH-11, Hfh11, Whn, nude, forkhead box protein N1, HNF-3/forkhead homolog 11, hepatocyte nuclear factor 3 forkhead homolog 11, winged-helix transcription factor nude
Species: mouse

Top Publications

  1. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
  2. doi Foxn1 is essential for vascularization of the murine thymus anlage
    Kazuya Mori
    Department of Immunology and Microbiology, Meiji University of Integrative Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Cell Immunol 260:66-9. 2010
  3. pmc CD40 engagement on dendritic cells, but not on B or T cells, is required for long-term control of murine gammaherpesvirus 68
    Francesca Giannoni
    Viral Immunology, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    J Virol 82:11016-22. 2008
  4. ncbi Expression of Dll4 and CCL25 in Foxn1-negative epithelial cells in the post-natal thymus
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:127-32. 2007
  5. ncbi Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS
    Rana Dajani
    Department of Anatomy and Cell Biology, University of Iowa, College of Medicine, 51 Newton Rd, Rm 1 111 BSB, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 292:G242-52. 2007
  6. ncbi New member of the winged-helix protein family disrupted in mouse and rat nude mutations
    M Nehls
    Department of Medicine I, University of Freiburg, Germany
    Nature 372:103-7. 1994
  7. ncbi 'Nude', a new hairless gene with pleiotropic effects in the mouse
    S P Flanagan
    Genet Res 8:295-309. 1966
  8. pmc Mapping of the nu gene using congenic nude strains and in situ hybridization
    Y Takahashi
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    J Exp Med 175:873-6. 1992
  9. ncbi Absence of thymus in a mouse mutant
    E M Pantelouris
    Nature 217:370-1. 1968
  10. ncbi NFS/N-nu/ + mice can macroscopically be distinguished from NFS/N- +/+ littermates by their thymic size and shape
    A Kojima
    Exp Cell Biol 52:107-10. 1984

Scientific Experts

Detail Information

Publications135 found, 100 shown here

  1. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
    ..Thus, FALC Lin(-)c-Kit(+)Sca-1(+) cells are T(H)2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'...
  2. doi Foxn1 is essential for vascularization of the murine thymus anlage
    Kazuya Mori
    Department of Immunology and Microbiology, Meiji University of Integrative Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Cell Immunol 260:66-9. 2010
    We addressed whether vascularization of the thymus anlage depends on Foxn1 expression. In the thymus anlagen of wild-type mice, CD31(+) endothelial cells are initially observed between epithelial cells on embryonic day (Ed)12...
  3. pmc CD40 engagement on dendritic cells, but not on B or T cells, is required for long-term control of murine gammaherpesvirus 68
    Francesca Giannoni
    Viral Immunology, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    J Virol 82:11016-22. 2008
    ..Taken together, our data suggest that CD40 engagement on DC, but not on T or B cells, is essential for effective long-term control of MHV-68...
  4. ncbi Expression of Dll4 and CCL25 in Foxn1-negative epithelial cells in the post-natal thymus
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:127-32. 2007
    b>Foxn1 transcription factor is known to be essential for development of the thymic organ...
  5. ncbi Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS
    Rana Dajani
    Department of Anatomy and Cell Biology, University of Iowa, College of Medicine, 51 Newton Rd, Rm 1 111 BSB, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 292:G242-52. 2007
    ..In conclusion, our studies demonstrate that induction of NF-kappaB and TNF-alpha balances protective (antiapoptotic) and detrimental (proinflammatory) pathways to determine hepatocellular fates during endotoxemia...
  6. ncbi New member of the winged-helix protein family disrupted in mouse and rat nude mutations
    M Nehls
    Department of Medicine I, University of Freiburg, Germany
    Nature 372:103-7. 1994
    Mutations at the nude locus of mice and rats disrupt normal hair growth and thymus development, causing nude mice and rats to be immune-deficient...
  7. ncbi 'Nude', a new hairless gene with pleiotropic effects in the mouse
    S P Flanagan
    Genet Res 8:295-309. 1966
  8. pmc Mapping of the nu gene using congenic nude strains and in situ hybridization
    Y Takahashi
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    J Exp Med 175:873-6. 1992
    ..We have used congenic nude strains and examined which of the six DNA markers were derived from the original nude mouse...
  9. ncbi Absence of thymus in a mouse mutant
    E M Pantelouris
    Nature 217:370-1. 1968
  10. ncbi NFS/N-nu/ + mice can macroscopically be distinguished from NFS/N- +/+ littermates by their thymic size and shape
    A Kojima
    Exp Cell Biol 52:107-10. 1984
  11. ncbi Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat
    J A Segre
    Whitehead Institute for Biomedical Research, Cambridge Massachusetts 02142, USA
    Genomics 28:549-59. 1995
    Mutations in the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in severely compromised immune system...
  12. ncbi A yeast artificial chromosome contig on mouse chromosome 11 encompassing the nu locus
    M Nehls
    Department of Medicine I, University of Freiburg, Germany
    Eur J Immunol 24:1721-3. 1994
    Mutations at the nude locus disrupt the homing process of T cell progenitor cells to the thymic rudiment, a key aspect of T cell differentiation...
  13. ncbi Regional localization of the nu mutation on mouse chromosome 11
    L G Byrd
    Zoology Department, University of Maryland, College Park
    Immunogenetics 37:157-9. 1993
  14. ncbi Two genetically separable steps in the differentiation of thymic epithelium
    M Nehls
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld, Heidelberg, Germany
    Science 272:886-9. 1996
    ..With the use of a targeted disruption of the whn gene, which recapitulates the phenotype of the athymic nude mouse, the WHN transcription factor was shown to be the product of the nude locus...
  15. pmc The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors
    C C Blackburn
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Proc Natl Acad Sci U S A 93:5742-6. 1996
    The nude mutation (nu) causes athymia and hairlessness, but the molecular mechanisms by which it acts have not been determined...
  16. ncbi The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation
    J L Brissette
    Cutaneous Biology Research Center, Massachusets General Hospital, Charlestown, USA
    Genes Dev 10:2212-21. 1996
    Mutations in the winged-helix nude (whn) gene result in the nude mouse and rat phenotypes...
  17. pmc The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system
    T Schlake
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Proc Natl Acad Sci U S A 94:3842-7. 1997
    In the mouse, the product of the nude locus, Whn, is required for the keratinization of the hair shaft and the differentiation of epithelial progenitor cells in the thymus...
  18. ncbi Characterization of mouse and human nude genes
    M Schorpp
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Immunogenetics 46:509-15. 1997
    ..into subcapsular, cortical, and medullary epithelial cells of the mature thymus requires the activity of the nude gene product Whn. Whn is also required for proper keratinization of the hair shaft...
  19. ncbi Association between mouse nude gene expression and the initiation of epithelial terminal differentiation
    D Lee
    Department of Dermatology, Massachusetts General Hospital, Charlestown, Massachusetts, 02129, USA
    Dev Biol 208:362-74. 1999
    Loss-of-function mutations in Whn (Hfh 11), a winged-helix/forkhead transcription factor, result in the nude mouse phenotype...
  20. ncbi Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation: implications for the self-renewal of cutaneous epithelia
    D M Prowse
    Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    Dev Biol 212:54-67. 1999
    ..This phenotype results from loss-of-function mutations in Whn (Hfh11), a winged-helix transcription factor...
  21. ncbi Chemokines define distinct microenvironments in the developing thymus
    C C Bleul
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Eur J Immunol 30:3371-9. 2000
    ..The in vivo significance of this finding is demonstrated by studies in the nude mouse where the thymic anlage lacks TECK and SDF-1 expression and prothymocytes home to the parathyroid anlage ..
  22. ncbi Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch
    J Gordon
    Centre for Genome Research Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
    Mech Dev 103:141-3. 2001
    ..The molecular mechanism that specifies this primordium into distinct organ domains is not known. The Gcm2 and Foxn1 transcription factors are required for development of the parathyroid and thymus respectively, and are attractive ..
  23. ncbi Hoxa3 and pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis
    D Su
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Dev Biol 236:316-29. 2001
    ..compound mutants initiates normal expression of the parathyroid-specific Gcm2 and thymus-specific Foxn1 genes. However, Gcm2 expression is reduced at E11...
  24. ncbi Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product
    C C Bleul
    MPI für Immunbiologie, Freiburg, Germany
    Eur J Immunol 31:2497-503. 2001
    ..their unique phenotype under the control of the winged-helix transcription factor Whn, which is lacking in the nude mouse. Whn-dependent genes may therefore be important regulators of lympho-epithelial interactions...
  25. ncbi Role of the nude gene in epithelial terminal differentiation
    Ruth M Baxter
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Invest Dermatol 118:303-9. 2002
    Loss-of-function mutations in Whn (Hfh11, Foxn1), a winged-helix/forkhead transcription factor, cause the nude phenotype, which is characterized by the abnormal morphogenesis of the epidermis, hair follicles, and thymus...
  26. ncbi Complete rescue of the nude mutant phenotype by a wild-type Foxn1 transgene
    Vincent T Cunliffe
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Mamm Genome 13:245-52. 2002
    ..paper we describe the production and analysis of mice carrying a 110-kb transgene that encompasses the wild-type Foxn1 genomic locus. Mutations in Foxn1 cause the nude phenotype...
  27. pmc Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid
    Pin Xian Xu
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Development 129:3033-44. 2002
    ..5 in Eya1(-/-) embryos. Our results indicate that Eya1 controls critical early inductive events involved in the morphogenesis of thymus, parathyroid and thyroid...
  28. ncbi Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice
    Gina Balciunaite
    Pediatric Immunology, Department of Research and Clinical biological Sciences, and The Children s Hospital, University of Basel, Basel, Switzerland
    Nat Immunol 3:1102-8. 2002
    ..these characteristics is dependent on expression of the forkhead (also known as winged-helix) transcription factor FoxN1, as a lack of functional FoxN1 results in aberrant epithelial morphogenesis and an inability to attract lymphoid ..
  29. pmc Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice
    Delphine Guy-Grand
    Unité de Biologie Moléculaire du Gène, INSERM U277 and Institut Pasteur, 75724 Paris Cedex 15, France
    J Exp Med 197:333-41. 2003
    ....
  30. ncbi A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation
    Dong Ming Su
    Department of Genetics, Life Sciences Building, University of Georgia, Athens, Georgia 30602, USA
    Nat Immunol 4:1128-35. 2003
    Thymic epithelial cells (TECs) are required for T cell maturation within the thymus. In the nude (Foxn1(nu/nu)) mouse, TECs fail to differentiate...
  31. ncbi Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs
    Nancy R Manley
    Department of Genetics, University of Georgia, Life Sciences, B 420A, Athens, GA 30602, USA
    Dev Biol 276:301-12. 2004
    ..However, some aspects of the Pbx1 mutant phenotype included specific defects that were less severe than those found in known Hox mutant mice, suggesting that some functions of Hox proteins in this region are Pbx1-independent...
  32. ncbi Ontogeny and regulation of IL-7-expressing thymic epithelial cells
    Monica Zamisch
    Science Park Research Division, University of Texas M D Anderson Cancer Center, Smithville, TX 78957, USA
    J Immunol 174:60-7. 2005
    ..5 and is expressed in a Foxn1-independent pathway...
  33. ncbi Dependence of self-tolerance on TRAF6-directed development of thymic stroma
    Taishin Akiyama
    Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Science 308:248-51. 2005
    ..Engraftment of thymic stroma of TRAF6(-/-) embryos into athymic nude mice induced autoimmunity...
  34. ncbi The cellular mechanism of Aire control of T cell tolerance
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 23:227-39. 2005
    ..In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops...
  35. ncbi Learning from nudity: lessons from the nude phenotype
    Lars Mecklenburg
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, USA
    Exp Dermatol 14:797-810. 2005
    In mice, rats, and humans, loss of function of Foxn1, a member of the winged helix/forkhead family of transcription factors, leads to macroscopic nudity and an inborn dysgenesis of the thymus...
  36. pmc Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Dev Biol 293:499-512. 2006
    ..rudiments fail to maintain the expression of the parathyroid-specific gene Gcm2 and the thymus-specific gene Foxn1 and subsequently undergo abnormal apoptosis, leading to a complete disappearance of organ primordia by E12.5...
  37. ncbi Formation of a functional thymus initiated by a postnatal epithelial progenitor cell
    Conrad C Bleul
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Nature 441:992-6. 2006
    ..For instance, cell-autonomous genetic defects of forkhead box N1 (Foxn1) and autoimmune regulator (Aire) in thymic epithelial cells cause primary immunodeficiency and autoimmunity, ..
  38. ncbi Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization
    Cunlan Liu
    Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
    Blood 108:2531-9. 2006
    ..Unexpectedly, CCL21, a CCR7 ligand, was expressed not by Foxn1-dependent thymic primordium but by Gcm2-dependent parathyroid primordium, whereas CCL25, a CCR9 ligand, was ..
  39. ncbi A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut National de la Santé et de la Recherche Médicale U668, Institut Pasteur, Paris F 75724, France
    Nat Immunol 7:1217-24. 2006
    ..We propose that bone marrow and thymic NK cell pathways generate distinct mouse NK cells with properties similar to those of the two human CD56 NK cell subsets...
  40. ncbi JunB is a gatekeeper for B-lymphoid leukemia
    R G Ott
    Institute of Pharmacology, Medical University of Vienna MUW, Vienna, Austria
    Oncogene 26:4863-71. 2007
    ..Thus, JunB functions as a gatekeeper during tumor evolution. In its absence, transformed leukemic cells acquire an enhanced proliferative capacity, which presages a more malignant disease...
  41. pmc Lack of Foxp3 function and expression in the thymic epithelium
    Adrian Liston
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 204:475-80. 2007
    ..Therefore, in mice the only known role for Foxp3 remains promotion of T reg cell differentiation within the T cell lineage, whereas there is no role for Foxp3 in thymic epithelial cells...
  42. pmc Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia
    Zhijie Liu
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Dev Biol 305:333-46. 2007
    ..These results suggest that Gcm2 is not required for pouch patterning or to establish the parathyroid domain, but is required for differentiation and subsequent survival of parathyroid cells...
  43. pmc Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus
    Julie Gordon
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    BMC Dev Biol 7:69. 2007
    ..Since the Foxn1 gene is expressed in all presumptive TECs from the early stages of thymus organogenesis and broadly in the adult ..
  44. ncbi Dedicated epithelial recipient cells determine pigmentation patterns
    Lorin Weiner
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Cell 130:932-42. 2007
    ..We identify Foxn1 (a transcription factor) as an activator of this "pigment recipient phenotype" and Fgf2 (a growth factor and Foxn1 ..
  45. pmc Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1066 Epalinges, Switzerland
    J Exp Med 205:2515-23. 2008
    ..Moreover, they strongly suggest that N1-expressing thymic progenitors interact with DL4-expressing TECs to suppress B lineage potential and to induce the first steps of intrathymic T cell development...
  46. pmc Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner
    Lizhen Chen
    Department of Genetics, Paul D Coverdell Center, University of Georgia, Athens, GA 30602, USA
    Blood 113:567-74. 2009
    ..The Foxn1 gene is a key regulator of TEC differentiation, and is required for multiple aspects of fetal TEC differentiation...
  47. pmc Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation
    Jing Cai
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 326:420-30. 2009
    ..Here we use compound genetic mutants to demonstrate that two transcription factors, Msx2 and Foxn1, are both required to maintain Notch1 expression in the hair follicle matrix...
  48. pmc Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos
    Ann V Griffith
    Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Dev Biol 327:216-27. 2009
    ..Analyses of Foxn1 and Gcm2 expression revealed a dorsal shift in the border between parathyroid- and thymus-fated domains at E11...
  49. doi Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium
    James Dooley
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Immunol 183:5042-9. 2009
    ..One is that within epithelial tissues derived from pharyngeal endoderm, FoxN1 expression is signature for the thymic epithelial lineage...
  50. pmc Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy
    Lili Cheng
    Department of Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 285:5836-47. 2010
    The transcription factor FoxN1 is essential for differentiation of thymic epithelial cell (TEC) progenitors during thymic organogenesis...
  51. pmc Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis
    Julie Gordon
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Dev Biol 339:141-54. 2010
    ..of Bmp4 or Alk3 from the pharyngeal endoderm and/or the surrounding mesenchyme using Foxg1-Cre, Wnt1-Cre or Foxn1-Cre...
  52. pmc Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution
    Liguang Sun
    Department of Biomedical Research, University of Texas Health Science Center at Tyler, 75708, USA
    Aging Cell 9:347-57. 2010
    ..The role of epithelial cell-autonomous gene FoxN1 may be involved in the process, but it is still a puzzle because of the shortage of evidence from gradual loss-of-..
  53. pmc Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage
    Tatiana Corbeaux
    Max Planck Institute of Immunobiology, Freiburg D 79108, Germany
    Proc Natl Acad Sci U S A 107:16613-8. 2010
    The thymus is essential for T-cell development. Here, we focus on the role of the transcription factor Foxn1 in the development and function of thymic epithelial cells (TECs) of the mouse...
  54. pmc Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium
    JianFei Guo
    Department of Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    J Mol Med (Berl) 89:263-77. 2011
    ..Although the FoxN1-null mutant develops a rudimentary two-dimensional (2D) cystic thymus, 2D thymic cyst lining resulting from a dGUO ..
  55. pmc Mechanisms of thymus organogenesis and morphogenesis
    Julie Gordon
    Department of Genetics, University of Georgia, Athens, Georgia 30602, USA
    Development 138:3865-78. 2011
    ..These studies are making significant progress in identifying the molecular and cellular mechanisms that control specification, early organogenesis and morphogenesis of the thymus...
  56. pmc Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells
    Erin C Zook
    Cell Biology, Neurobiology and Anatomy Graduate Program, Stritch Shool of Medicine, Loyola University Chicago, Maywood, IL, USA
    Blood 118:5723-31. 2011
    The forkhead box n1 (Foxn1) transcription factor is essential for thymic organogenesis during embryonic development; however, a functional role of Foxn1 in the postnatal thymus is less well understood...
  57. pmc Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence
    Craig S Nowell
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    PLoS Genet 7:e1002348. 2011
    The forkhead transcription factor Foxn1 is indispensable for thymus development, but the mechanisms by which it mediates thymic epithelial cell (TEC) development are poorly understood...
  58. pmc Age-Related Disruption of Steady-State Thymic Medulla Provokes Autoimmune Phenotype via Perturbing Negative Selection
    Jiangyan Xia
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA
    Aging Dis 3:248-59. 2012
    ..Age-related FoxN1 decline induces disruption of medullary thymic epithelial cells (mTECs)...
  59. pmc Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis
    Zhijie Zhang
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Int J Biol Sci 8:1156-67. 2012
    Mutation in the "nude" gene, i.e. the FoxN1 gene, induces a hairless phenotype and a rudimentary thymus gland in mice (nude mouse) and humans (T-cell related primary immunodeficiency)...
  60. pmc Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression
    Phillip M Garfin
    Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    J Exp Med 210:1087-97. 2013
    ..In RB family mutant TECs, increased activity of E2F transcription factors drives increased expression of Foxn1, a central regulator of the thymic epithelium...
  61. pmc Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche
    Erin C Zook
    Cell Biology, Neurobiology, and Anatomy Graduate Program, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153
    J Immunol 191:5583-93. 2013
    b>Foxn1 is essential for thymic organogenesis and T lymphopoiesis...
  62. pmc Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging
    P BURNLEY
    Department of Cell Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Cell Death Dis 4:e932. 2013
    The p63 gene regulates thymic epithelial cell (TEC) proliferation, whereas FoxN1 regulates their differentiation. However, their collaborative role in the regulation of TEC homeostasis during thymic aging is largely unknown...
  63. pmc Regeneration of the aged thymus by a single transcription factor
    Nicholas Bredenkamp
    Medical Research Council Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, SCRM Building, 5 Little France Drive, Edinburgh EH16 4UU, UK
    Development 141:1627-37. 2014
    ..Recently, diminished expression of the thymic epithelial cell (TEC)-specific transcription factor Forkhead box N1 (FOXN1) has been implicated as a component of the mechanism regulating age-related involution...
  64. ncbi Atypical memory phenotype T cells with low homeostatic potential and impaired TCR signaling and regulatory T cell function in Foxn1Delta/Delta mutant mice
    Shiyun Xiao
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    J Immunol 179:8153-63. 2007
    ..Our results suggest that the phenotype of peripheral T cells in Foxn1Delta/Delta mutant mice is the result of atypical progenitor cells developing in an abnormal thymic microenvironment with a deficient TCR and IL7 signaling system...
  65. ncbi T cell development from kit-negative progenitors in the Foxn1Delta/Delta mutant thymus
    Shiyun Xiao
    Department of Genetics, Coverdell Center, University of Georgia, Athens, GA 30602, USA
    J Immunol 180:914-21. 2008
    Foxn1Delta is a hypomorphic allele of the nude gene that causes arrested thymic epithelial cell differentiation and abnormal thymic architecture lacking cortical and medullary domains...
  66. ncbi Contribution of double-negative thymic precursors to CD8alpha alpha (+) intraepithelial lymphocytes of the gut in mice bearing TCR transgenes
    D Guy-Grand
    Unité de Biologie Moléculaire du Gène, INSERM U277 and Institut Pasteur, Paris, France
    Eur J Immunol 31:2593-602. 2001
    ..between the TCR(+) lymphocytes present in the lymphoid organs and the gut mucosa in euthymic versus athymic (nude) animals...
  67. ncbi Lack of Delta like 1 and 4 expressions in nude thymus anlages
    Noriyuki Tsukamoto
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Funai gun, Kyoto 629 0392, Japan
    Cell Immunol 234:77-80. 2005
    ..In contrast, epithelial cells of the nude thymus anlages express neither Dll1 nor Dll4. These results indicate that expressions of Dll1 and Dll4 in thymic epithelial cells are regulated by Foxn1 transcriptional factor.
  68. pmc Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint
    Alexander P Miceli
    BRIGHT Institute, Department of Internal Medicine, Division of Molecular Oncology, and Department of Cell Biology and Physiology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri, USA
    Mol Cell Biol 32:348-64. 2012
    ..Taken together, our data demonstrate the ability of the ARF tumor suppressor to respond to hypergrowth stimuli to prevent unwarranted tumor formation...
  69. pmc Beta-catenin inhibits melanocyte migration but induces melanoma metastasis
    S J Gallagher
    Centre de Recherche, Developmental Genetics of Melanocytes, Institut Curie, Orsay, France
    Oncogene 32:2230-8. 2013
    ..These results highlight that metastasis formation requires a series of successful cellular processes, any one of which may not be optimally efficient...
  70. pmc Comparing the MRI appearance of the lymph nodes and spleen in wild-type and immuno-deficient mouse strains
    Vasiliki Economopoulos
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 6:e27508. 2011
    ..Four mice from each of four different mouse strains (nude, NOG, C57BL/6, CB-17 SCID (SCID)) were imaged weekly for one month...
  71. doi B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-α, perforin)
    Thomas Kammertoens
    Institut fur Immunologie, Charite, Campus Benjamin Franklin, Berlin, Germany
    Int J Cancer 131:1499-508. 2012
    ....
  72. pmc Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice
    Eric J Seeley
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Immunol 190:4717-24. 2013
    ..Removal of these two modulators of the immune response enhances antibacterial immunity and improves survival. These results may have implications for how states of catecholamine excess influence the host response to bacterial infections...
  73. ncbi Susceptibility of +/+, +/nu and nu/nu BALB/c mice to ocular herpes simplex virus infection
    C R Brandt
    Department of Ophthalmology, University of Wisconsin, Madison 53706
    Ophthalmic Res 24:332-7. 1992
    Athymic (nude) mice have played an important role in defining the function of the immune system and its role in infectious diseases...
  74. pmc The NIH-3 immunodeficient mouse is a model for Lyme borreliosis myositis and carditis
    D L Defosse
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455
    Am J Pathol 141:3-10. 1992
    ..In addition to T-cell deficiency due to the nude mutation, these mice have an x-linked defect affecting the B-cell maturation and the beige mutation resulting in ..
  75. pmc Immune responses to Cryptosporidium muris and Cryptosporidium parvum in adult immunocompetent or immunocompromised (nude and SCID) mice
    V McDonald
    Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, United Kingdom
    Infect Immun 60:3325-31. 1992
    ..In contrast, severe combined immunodeficiency (SCID) mice or nude mice had a chronic infection lasting at least 109 days. The development of the C...
  76. pmc Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice
    S Suematsu
    Division of Immunology, Osaka University, Japan
    Proc Natl Acad Sci U S A 89:232-5. 1992
    ..These results provide firm evidence of the critical role of IL-6 in the plasmacytoma development...
  77. ncbi Caries susceptibility in inbred mouse strains and inheritance patterns in F1 and backcross (N2) progeny from strains with high and low caries susceptibility
    Y Kurihara
    Department of Pedodontics, Nihon University School of Dentistry, Matsudo, Chiba, Japan
    Caries Res 25:341-6. 1991
    ..Furthermore, the effect of nu/nu mutation on caries susceptibility in mice was also examined...
  78. ncbi Heterotransplantation of primary and established human tumour cells in nude mice
    A Noel
    Laboratory of Biology, University of Liege, Belgium
    Anticancer Res 15:1-7. 1995
    Previous successful transplantations of human tumour cells into athymic nude mice have been described when cells were injected with a reconstituted basement membrane (matrigel)...
  79. ncbi A comparative Mac-1 immunocytochemical and lectin histochemical study of microglial cells in the normal and athymic mice
    W W Htain
    Department of Anatomy, Faculty of Medicine, National University of Singapore
    Glia 12:44-51. 1994
    ..Mac-1 antibody (against CR3 antigens) and the intensity of staining were studied in both the homozygous athymic nude mouse (nu/nu) and normal BALB/c mouse (+/+)...
  80. pmc Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice
    N E Kohl
    Department of Cancer Research, Merck Research Laboratories, West Point, PA 19486
    Proc Natl Acad Sci U S A 91:9141-5. 1994
    ..This compound also suppressed the growth of tumors arising from ras-transformed Rat1 cells in nude mice by 66%. Under the same conditions, doxorubicin inhibited tumor growth by 33%...
  81. ncbi Role of x-linked immunodeficiency (xid) and NK activity in rejection of human tumor xenotransplants in nude mice
    K Maruo
    Central Institute for Experimental Animals, Kanagawa, Japan
    APMIS 101:345-52. 1993
    In order to elucidate the factors influencing the takes of human tumor xenografts in nude mice, we compared the transplantability of human tumors in nude mice with additional genetic defects in the immune system...
  82. ncbi Enhanced human tumor cell transplantability in a new congenic immunodeficient mouse; KSN-BNX
    Y Ishigaki
    Department of Radiation Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    Folia Microbiol (Praha) 43:493-4. 1998
    ..the deficiency of natural killer (NK) activity and xid that decreases the production of immunoglobulin) into KSN nude mice with high reproductive performances...
  83. ncbi Spontaneous mutations in SELH/Bc mice due to insertions of early transposons: molecular characterization of null alleles at the nude and albino loci
    M Hofmann
    Department of Developmental Immunology, Max Planck Institute for Immunology, Freiburg, Germany
    Genomics 52:107-9. 1998
  84. ncbi Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation
    N Meier
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Mech Dev 89:215-21. 1999
    The molecular basis of the characteristic hair growth disorder in nude mice that carry a defective Whn transcription factor gene is unknown...
  85. pmc Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure
    M J Burne
    Division of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
    J Clin Invest 108:1283-90. 2001
    ..These results demonstrate that the CD4(+) T cell is an important mediator of ischemic ARF, and targeting this cell may yield novel therapies...
  86. ncbi The Gli2 transcription factor is required for normal mouse mammary gland development
    M T Lewis
    Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz, California 95064, USA
    Dev Biol 238:133-44. 2001
    ..DeltaGli2 heterozygotes also demonstrated an elevated frequency and severity of focal ductal dysplasia relative to that of wild type littermate- and age-matched control animals...
  87. ncbi Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes
    Silvia Montaner
    Cell Growth Regulation Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 3:23-36. 2003
    ..Endothelial cells expressing vGPCR were further able to promote tumor formation by cells expressing KSHV latent genes, suggestive of a cooperative role among viral genes in the promotion of Kaposi's sarcomagenesis...
  88. ncbi IL-4 exacerbates anaphylaxis
    Richard T Strait
    Division of Emergency Medicine, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 170:3835-42. 2003
    ..Synergy between IL-4 and vasoactive mediators during the effector phase of allergic inflammation may both contribute to allergic immunopathology and enhance protective immunity against gastrointestinal worms...
  89. ncbi Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK
    Ling Zhao
    Laboratory of Genetics and Physiology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:44093-100. 2004
    ..These experiments establish that two distinct Stat3 signaling pathways emanating from gp130 are utilized in mammary tissue...
  90. pmc TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice
    Reiko Horai
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Clin Invest 114:1603-11. 2004
    ..These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40...
  91. ncbi FOXN1 is critical for onycholemmal terminal differentiation in nude (Foxn1) mice
    Lars Mecklenburg
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Invest Dermatol 123:1001-11. 2004
    Nude mice have a mutation in the transcription factor Foxn1(nu), resulting in downregulation of hair keratins. Although hair follicles develop normally, the hair fibers become structurally weak, curl, and break off at the surface...
  92. ncbi Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles
    Satoshi Nonaka
    Department of Microbiology and Immunology, Keio University School of Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 174:1906-12. 2005
    ..These findings indicate that all LN, including mesenteric LN, PP, and isolated lymphoid follicles, are not an absolute requirement for the development of gammadelta-IEL in athymic nu/nu mice...
  93. ncbi The regional distribution and relative frequency of gastrointestinal endocrine cells in the nude mice, Balb/c-nu/nu: an immunohistochemical study
    S K Ku
    Pharmacology and Toxicology Laboratory, Dong Wha Pharmaceutical Industrial Co Ltd, Anyang 430 017, Repubulic of Korea
    Anat Histol Embryol 35:104-10. 2006
    ..of the gastrointestinal (GI) tract - fundus, pylorus, duodenum, jejunum, ileum, cecum, colon and rectum of the nude mouse, Balb/c-nu/nu were studied with immunohistochemical method using six types of anti-sera against serotonin, ..
  94. ncbi CD38 cross-linking enhances TLR-induced B cell proliferation but decreases IgM plasma cell differentiation
    Nataly Manjarrez-Orduno
    Molecular Biomedicine Department, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico City, Mexico
    Eur J Immunol 37:358-67. 2007
    ....
  95. ncbi Mesenchymal cells are required for functional development of thymic epithelial cells
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:953-64. 2007
    ..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
  96. pmc Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
    Xuri Li
    Vesalius Research Center, VIB, 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 28:1614-20. 2008
    ..The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear...
  97. pmc Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma
    Aude Bressenot
    Service d Anatomie et de Cytologie Pathologiques, Hopital de Brabois, Centre Hospitalier Régional et Universitaire Nancy, Vandoeuvre les Nancy, France
    J Histochem Cytochem 57:289-300. 2009
    ..The absence of caspase-7 activation in some caspase-3-expressing cells undergoing Foscan-PDT shows the relevance of using antibodies that can discriminate caspase-dependent apoptotic pathways...
  98. doi IL-12 inhibits TNF-alpha induced osteoclastogenesis via a T cell-independent mechanism in vivo
    Masako Yoshimatsu
    Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Bone 45:1010-6. 2009
    ..These results suggest that IL-12 inhibits TNF-alpha-mediated osteoclastogenesis and induces apoptotic changes through an interaction between TNF-alpha-induced Fas and IL-12-induced FasL, in vivo, via a T cell-independent mechanism...
  99. pmc A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis
    J H Tchaicha
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Oncogene 29:4460-72. 2010
    ..Finally, these results show that an adhesion and signaling axis normally involved in developmental brain angiogenesis is pathologically exploited in adult brain tumors...
  100. pmc Adverse events post smallpox-vaccination: insights from tail scarification infection in mice with Vaccinia virus
    Bruno E F Mota
    Laboratorio de Virus, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS ONE 6:e18924. 2011
    ..Finally, NUDE athymic mice showed a similar outcome of infection as Rag1(-/-), and passive transfer of WT T cells to Rag1(-/-) ..
  101. ncbi Mutations in mice that influence natural killer (NK) cell activity
    E A Clark
    Immunogenetics 12:601-13. 1981
    ..Two mutations, nude (nu) and lymphoproliferation (lpr), produced elevated NK-cell-mediated lysis...

Research Grants15

  1. Immunological control of a persistent viral infection
    Sally R Sarawar; Fiscal Year: 2010
    ..The results obtained may have broader significance in understanding the mechanisms controlling T cell activation or tolerance, in general. ..
  2. Pneumococcal immunization through a novel mechanism
    Richard Malley; Fiscal Year: 2010
    ..abstract_text> ..
  3. Interaction between influenza virus and H. influenzae
    Sally Sarawar; Fiscal Year: 2007
    ..This could be particularly important during an influenza pandemic and may be more broadly applicable to other respiratory viruses. [unreadable] [unreadable] [unreadable]..
  4. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2006
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  5. Role of Sonic hedgehog in pharyngeal organ development
    Nancy Manley; Fiscal Year: 2005
    ..These tools will also allow us to expand our investigation to other signaling pathways, such as BMPs and FGFs, that are known to interact with the Shh pathway in other organs. ..
  6. CHEMOKINES IN THE IMMUNE RESPONSE TO A VIRAL INFECTION
    Sally Sarawar; Fiscal Year: 2002
    ..3) The role of the CXCR2 chemokine receptor homologue in viral pathogenesis will be determined using a mutant virus in which the gene encoding the CXCR2 homologue has been inactivated. ..
  7. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2004
    ..The CTP have been shown to rapidly reconstitute the CD4+ and CD8' T cells of irradiated athymic nude mice via an extrathymic pathway...
  8. Pneumolysin, Innate and Acquired Immunity to Pneumococci
    Richard Malley; Fiscal Year: 2005
    ..The establishment of a link between the innate and the acquired arm of the immune response to pneumococcus may provide a better understanding of the mechanisms by which immunity to pneumococcus is acquired. ..
  9. Regulation of thymic epithelial cell differentiation
    Nancy Manley; Fiscal Year: 2007
    ..Initial TEC differentiation depends on the function of Foxn1, which encodes a forkhead transcription factor gene, providing a unique resource to investigate Foxn1 function...
  10. Genetic analysis of thymus organogenesis
    Nancy Manley; Fiscal Year: 2007
    ..abstract_text> ..
  11. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2007
    ..abstract_text> ..
  12. Modeling the effects of INK4 alpha ARF loss on gliomas
    Eric Holland; Fiscal Year: 2003
    ....
  13. Pre-Clinical Trials of GEM Models for Gliomas
    Eric Holland; Fiscal Year: 2007
    ..abstract_text> ..
  14. Gene expression in non-functional CD8 T cells
    Sally Sarawar; Fiscal Year: 2005
    ..The data are likely to lead to a new understanding of how CD8 T cells function in the control of persistent viral infections and mechanisms of CD8 T cell activation. ..
  15. Mechanisms of cervical thymus development
    Nancy Manley; Fiscal Year: 2008
    ..Data from these recent reports and from our lab indicate that the cervical thymus in mice is not identifiable by Foxn1 gene expression before the newborn stage, and is frequently associated with the parathyroid and/or thyroid glands...