Flt3l

Summary

Gene Symbol: Flt3l
Description: FMS-like tyrosine kinase 3 ligand
Alias: Flt3lg, Ly72L, fms-related tyrosine kinase 3 ligand, flt3 ligand
Species: mouse

Top Publications

  1. pmc Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 204:2561-8. 2007
  2. ncbi Structural analysis of human and murine flt3 ligand genomic loci
    S D Lyman
    Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Oncogene 11:1165-72. 1995
  3. ncbi Expression of the flt3 receptor and its ligand on hematopoietic cells
    K Brasel
    Department of Immunobiology, Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Leukemia 9:1212-8. 1995
  4. ncbi Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand
    T McClanahan
    DNAX Research Institute of Molecular and Cellular Biology, Department of Molecular Biology, Palo Alto, CA 94304, USA
    Blood 88:3371-82. 1996
  5. ncbi c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities
    S D Lyman
    Department of Molecular Genetics, Immunex Corp, Seattle, WA 98101, USA
    Blood 91:1101-34. 1998
  6. ncbi Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    H J McKenna
    Immunex Corporation, Seattle, WA 98101, USA
    Blood 95:3489-97. 2000
  7. ncbi Flt3 ligand therapy for recipients of allogeneic bone marrow transplants expands host CD8 alpha(+) dendritic cells and reduces experimental acute graft-versus-host disease
    Takanori Teshima
    Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, 48109 0942, USA
    Blood 99:1825-32. 2002
  8. ncbi Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice
    Meredith O'Keeffe
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia
    Blood 99:2122-30. 2002
  9. ncbi Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool
    Ewa Sitnicka
    Department of Stem Cell Biology, Institute of Laboratory Medicine, University Hospital of Lund, BMC, B12, Klinikgatan 26, 221 84 Lund, Sweden
    Immunity 17:463-72. 2002
  10. ncbi Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs
    Pierre Brawand
    Amgen Inc, Seattle, WA 98101, USA
    J Immunol 169:6711-9. 2002

Research Grants

Scientific Experts

  • Mattias N D Svensson
  • Julia K Bohannon
  • Lai Guan Ng
  • Tracey L Papenfuss
  • Keisuke Horiuchi
  • Kimberly D Dyer
  • S Yang
  • RODNEY L MOSLEY
  • B J Weigel
  • Richard Riley
  • O Psenak
  • B J Masten
  • Ewa Sitnicka
  • Pierre Brawand
  • Meredith O'Keeffe
  • Sten Eirik W Jacobsen
  • Natalija Buza-Vidas
  • Shabnam Kharazi
  • Charlotta Böiers
  • Min Cheng
  • Christina T Jensen
  • Ralph M Steinman
  • Michel C Nussenzweig
  • Miriam Merad
  • Guillaume Darrasse-Jèze
  • Kang Liu
  • Linda Kenins
  • Ben Fancke
  • S D Lyman
  • Hubertus Hochrein
  • Pierre Guermonprez
  • Niroshana Anandasabapathy
  • Devendra K Agrawal
  • Tewfik Miloud
  • Florent Ginhoux
  • Jehad H Edwan
  • Zhiliang Wang
  • Markus G Manz
  • Mark Suter
  • Angus W Thomson
  • A Staffas
  • Nathalie Deckx
  • Brian R Rosborough
  • Jan Fric
  • Shamim A Mollah
  • Arivazhagan Sambandam
  • Yasuyuki Saito
  • Samira Tamoutounour
  • M Dehlin
  • Yi Ling Chen
  • Cheolho Cheong
  • K Brasel
  • Heidi A Schreiber
  • Alice O Kamphorst
  • Ali Xiong
  • Fabienne Billiard
  • Juliana Idoyaga
  • Matthew M Meredith
  • Matthew Meredith
  • Christina Brumshagen
  • Ana Pereira de Sousa
  • Melissa A Kinnebrew
  • Daisuke Sugiyama
  • Pia Björck
  • Stephanie Deroubaix
  • Bernard Malissen
  • Julie Helft
  • Joseph J Dolence
  • Maria Luisa del Rio
  • Hiromi Ohtsuka
  • Hugo Mouquet
  • Natalio Garbi
  • Günter J Hämmerling
  • Kai hui Yao
  • Anne Hultquist
  • Gabriel D Victora
  • Tatsuaki Tsuruyama
  • Michael L Dustin
  • Leonia Bozzacco
  • Xiao song Xiang
  • Flavia Q Pirih
  • Michael Heuser
  • Taheri Sathaliyawala
  • Marco Colonna
  • Loredana Frasca
  • Daniel Larocque
  • Melanie Greter
  • Milena Bogunovic
  • Dior Kingston
  • Zhifei Shao

Detail Information

Publications104 found, 100 shown here

  1. pmc Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 204:2561-8. 2007
    ..In terms of function, expression of distinctive cell surface receptors, and location in lymphoid organs, NK1.1(+)B220(+)CD11c(+) appear to be the murine equivalent of human CD56(bright) NK cells...
  2. ncbi Structural analysis of human and murine flt3 ligand genomic loci
    S D Lyman
    Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Oncogene 11:1165-72. 1995
    Both the murine and human genomic loci that encode flt3 ligand have been cloned. flt3 ligand is a hematopoietic growth factor that stimulates the proliferation of stem and progenitor cells...
  3. ncbi Expression of the flt3 receptor and its ligand on hematopoietic cells
    K Brasel
    Department of Immunobiology, Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Leukemia 9:1212-8. 1995
    ..Surface expression of flt3 receptor and flt3 ligand were detected by flow cytometry using biotinylated human flt3 ligand or biotinylated soluble human flt3 ..
  4. ncbi Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand
    T McClanahan
    DNAX Research Institute of Molecular and Cellular Biology, Department of Molecular Biology, Palo Alto, CA 94304, USA
    Blood 88:3371-82. 1996
    ..performed a comprehensive analysis of cell lines and tissues to compare and contrast the expression patterns of Flt3 ligand (FL), c-Kit ligand (KL), and macrophage colony-stimulating factor as well as their receptors, Flt3, c-Kit, and ..
  5. ncbi c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities
    S D Lyman
    Department of Molecular Genetics, Immunex Corp, Seattle, WA 98101, USA
    Blood 91:1101-34. 1998
  6. ncbi Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    H J McKenna
    Immunex Corporation, Seattle, WA 98101, USA
    Blood 95:3489-97. 2000
    ..The flt3 ligand (flt3L) is a growth factor for hematopoietic progenitors and induces hematopoietic progenitor and stem cell ..
  7. ncbi Flt3 ligand therapy for recipients of allogeneic bone marrow transplants expands host CD8 alpha(+) dendritic cells and reduces experimental acute graft-versus-host disease
    Takanori Teshima
    Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, 48109 0942, USA
    Blood 99:1825-32. 2002
    Recent evidence suggests that dendritic cells (DCs) can regulate and amplify immune responses. Flt3 ligand (FL)-derived DC function was tested as a stimulator of allogeneic lymphocytes in vitro and in vivo...
  8. ncbi Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice
    Meredith O'Keeffe
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia
    Blood 99:2122-30. 2002
    ..Such selective expansion of DC populations and alterations in their cytokine-secretion capacity have implications for clinical use of the studied cytokines in immune modulation...
  9. ncbi Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool
    Ewa Sitnicka
    Department of Stem Cell Biology, Institute of Laboratory Medicine, University Hospital of Lund, BMC, B12, Klinikgatan 26, 221 84 Lund, Sweden
    Immunity 17:463-72. 2002
    ..first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable ..
  10. ncbi Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs
    Pierre Brawand
    Amgen Inc, Seattle, WA 98101, USA
    J Immunol 169:6711-9. 2002
    ..study, we report that large numbers of bone marrow-derived murine CD11c(+)B220(+) pDCs can be generated with Flt3 ligand (FL) as the sole exogenous differentiation/growth factor and that pDC generation is regulated in vivo by FL ..
  11. pmc The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3
    Angela D'Amico
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
    J Exp Med 198:293-303. 2003
    b>Flt3 ligand (Flt3L) is a growth factor for hemopoietic progenitors and can promote the expansion of both conventional dendritic cells (DCs) and plasmacytoid predendritic cells (p-preDCs)...
  12. ncbi Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution
    Terry J Fry
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 104:2794-800. 2004
    ..Indeed, flt3 ligand (flt3L) treatment of athymic mice subjected to T-cell depletion (without DC depletion) substantially enhanced ..
  13. ncbi No defect in T-cell priming, secondary response, or tolerance induction in response to inhaled antigens in Fms-like tyrosine kinase 3 ligand-deficient mice
    Thierry Walzer
    Amgen Inc, Seattle, WA 98119, USA
    J Allergy Clin Immunol 115:192-9. 2005
    ..Fms-like tyrosine kinase 3 ligand (FLT3L) is a hematopoietic growth factor that drives the development of multiple subsets of DCs in the lymphoid organs.
  14. ncbi Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development
    Meredith O'Keeffe
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Int Immunol 17:307-14. 2005
    ..This points to a possible clinical use of FL to prevent autoimmune disease...
  15. ncbi Notch signaling controls the generation and differentiation of early T lineage progenitors
    Arivazhagan Sambandam
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 6:663-70. 2005
    ..In contrast, multipotent hematopoietic progenitors circulated in the blood even in the absence of Notch signaling, suggesting that critical Notch signals during early T lineage development are delivered early after thymic entry...
  16. ncbi Use of flt3 ligand to evaluate residual hematopoiesis after heterogeneous irradiation in mice
    Marie Prat
    Institut de Radioprotection et de Surete Nucleaire, DRPH SRBE, Fontenay aux Roses, France
    Radiat Res 166:504-11. 2006
    We evaluated the possibility of using plasma Flt3 ligand (FL) concentration as a biological indicator of bone marrow function after heterogeneous irradiation. Mice were irradiated with 4, 7...
  17. ncbi Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
    Ewa Sitnicka
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 110:2955-64. 2007
    ....
  18. ncbi M-CSF: a novel plasmacytoid and conventional dendritic cell poietin
    Ben Fancke
    Research Department, Bavarian Nordic GmbH, Martinsried, Germany
    Blood 111:150-9. 2008
    ..It is noteworthy that using mice deficient in FL indicated that the M-CSF-driven generation of pDCs and cDCs in vitro and in vivo was independent of endogenous FL...
  19. doi Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment
    Lee Kim Swee
    Departement Biomedizin Basel, University of Basel, Switzerland
    Blood 113:6277-87. 2009
    Fms-like tyrosine kinase 3 ligand (FLT3L) plays a major role in dendritic cell (DC) biology...
  20. pmc Signal transduction inhibition of APCs diminishes th17 and Th1 responses in experimental autoimmune encephalomyelitis
    Mario Skarica
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore MD 21231, USA
    J Immunol 182:4192-9. 2009
    ..Thus, use of this class of signal transduction inhibitors may represent a novel method to treat autoimmunity by dampening the autoreactive polarizing condition driven by DCs...
  21. doi The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis
    Dior Kingston
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 114:835-43. 2009
    ..These data thus show the concerted action of GM-CSF and Flt3-ligand on DC homeostasis in vivo...
  22. pmc Feedback control of regulatory T cell homeostasis by dendritic cells in vivo
    Guillaume Darrasse-Jèze
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1853-62. 2009
    ..The increase in T reg cells induced by DC expansion is sufficient to prevent type 1 autoimmune diabetes and IBD, which suggests that interference with this feedback loop will create new opportunities for immune-based therapies...
  23. pmc HIV gag protein is efficiently cross-presented when targeted with an antibody towards the DEC-205 receptor in Flt3 ligand-mobilized murine DC
    Leonia Bozzacco
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10065 6399, USA
    Eur J Immunol 40:36-46. 2010
    ..and this subset can be increased 10-fold in numbers following Fms-like tyrosine kinase 3 ligand (Flt3L) treatment in vivo. Therefore, we studied cross-presentation by abundant Flt3L DC using HIV gag protein...
  24. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
    ..Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program...
  25. doi Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development
    Charlotta Böiers
    Hematopoietic Stem Cell Laboratory, Lund Stem Cell Center, Lund University, Lund, Sweden
    Blood 115:5061-8. 2010
    ..expression of FLT3 was found in preGMP compared with GMP, and preGMPs were more responsive to stimulation with FLT3 ligand (FL)...
  26. pmc Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling
    Taheri Sathaliyawala
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
    Immunity 33:597-606. 2010
    ..The cytokine Flt3 ligand (Flt3L) controls the development of DCs and is particularly important for the pDC and CD8(+) cDC and their ..
  27. pmc Threshold levels of Flt3-ligand are required for the generation and survival of lymphoid progenitors and B-cell precursors
    Joseph J Dolence
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Immunol 41:324-34. 2011
    ..Together, these data suggest that Flt3 signaling initiates a cascade of events in Flt3(low) precursors that promote the survival of LHP from which BCP are derived...
  28. pmc Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
    Niroshana Anandasabapathy
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 208:1695-705. 2011
    ..DCs in both sites shared an intrinsic requirement for Flt3 ligand. Microarrays revealed differences in expression of transcripts encoding surface molecules, transcription ..
  29. pmc Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    Melissa A Kinnebrew
    Infectious Diseases Service, Department of Medicine, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 36:276-87. 2012
    ..Thus, CD103(+)CD11b(+) LPDCs, in addition to promoting long-term tolerance to ingested antigens, also rapidly produce IL-23 in response to detection of flagellin in the lamina propria...
  30. pmc Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage
    Matthew M Meredith
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 209:1153-65. 2012
    ..Our results indicate that CD11c-expressing non-cDCs make significant contributions to initiating immunity to parasites and tumors...
  31. pmc Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection
    Pierre Guermonprez
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA
    Nat Med 19:730-8. 2013
    ..triggered by Plasmodium infection that regulates dendritic cell homeostasis and adaptive immunity through Flt3 ligand (Flt3l) release...
  32. doi Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin
    Samira Tamoutounour
    Centre d Immunologie de Marseille Luminy CIML, UM2 Aix Marseille Université, 13288 Marseille Cedex 9, France INSERM U1104, 13288 Marseille Cedex 9, France CNRS UMR7280, 13288 Marseille Cedex 9, France
    Immunity 39:925-38. 2013
    ..Therefore, a high degree of functional specialization occurs among the mononuclear phagocytes of the skin. ..
  33. pmc Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells
    Shamim A Mollah
    Hospital Informatics, Rockefeller University, New York, New York, USA
    J Invest Dermatol 134:1265-75. 2014
    ..Here, we build on the observation that Langerin-CD11b- migDCs are Fms-like tyrosine kinase 3 ligand (Flt3L) dependent and strongly Flt3L responsive, which may relate them to classical DCs...
  34. ncbi Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells
    S D Lyman
    Immunex Research and Development Corporation, Seattle, Washington 98101
    Cell 75:1157-67. 1993
    ....
  35. ncbi Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs
    C Hannum
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304 1104
    Nature 368:643-8. 1994
    ....
  36. ncbi Selective thymus settling regulated by cytokine and chemokine receptors
    Benjamin A Schwarz
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 178:2008-17. 2007
    ..We conclude that fms-like tyrosine kinase receptor-3 signaling is required for the generation of T lineage-competent progenitors, which selectively express molecules, including CCR9, that allow them to settle within the thymus...
  37. ncbi Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy
    Natalija Buza-Vidas
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 110:424-32. 2007
    ....
  38. pmc Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types
    Loredana Frasca
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Leukoc Biol 88:69-78. 2010
    ..Furthermore, this study shows that IL-15 trans-presentation can work in conjunction with other signals, such as CD70/CD27 interactions, to mediate CD8 T cell homeostasis efficiently...
  39. doi Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas
    Tatsuaki Tsuruyama
    Department of Forensic Medicine and Molecular Pathology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Leukoc Biol 88:107-16. 2010
    ..Clones with the dual integrations grew faster in IL-7 and FLT3L-supplemented medium than clones with Stat5a integration alone...
  40. pmc Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6
    Flavia Q Pirih
    University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e13657. 2010
    ..In conclusion, PTH acts with Flt-3L to maintain hematopoietic cells by limiting apoptosis. IL-6 is a critical mediator of bone marrow cell expansion and is responsible for PTH actions in hematopoietic cell expansion...
  41. doi Organ-specific cellular requirements for in vivo dendritic cell generation
    Tewfik Miloud
    Division of Molecular Immunology, German Cancer Research Center, Heidelberg 60120, Germany
    J Immunol 188:1125-35. 2012
    ..b>Flt3 ligand (Flt3-L) is critical for instructing DC generation throughout different organs...
  42. pmc Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice
    Fabienne Billiard
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591, USA
    J Exp Med 209:1011-28. 2012
    ..These results identify Dll4-Notch as a novel Flt3-alternative pathway important for regulating tDC-mediated T(reg) cell homeostasis and autoimmunity...
  43. doi Dendritic cell homeostasis is maintained by nonhematopoietic and T-cell-produced Flt3-ligand in steady state and during immune responses
    Yasuyuki Saito
    Division of Hematology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 43:1651-8. 2013
    ..Fms-related tyrosine kinase 3 ligand (Flt3L) is an essential, nonredundant cytokine for DC progenitor to lymphoid tissue DC differentiation and maintenance...
  44. doi Cerebrospinal Flt3 ligand correlates to tau protein levels in primary Sjögren's syndrome
    M Dehlin
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Scand J Rheumatol 42:394-9. 2013
    ..The fms-related tyrosine kinase 3 ligand (Flt3L) is a maturation factor essential for brain homeostasis...
  45. pmc A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors
    Yi Ling Chen
    Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei 100, Taiwan
    J Exp Med 210:2515-22. 2013
    ..Here, we report a synergistic role for IFN-I and Flt3 ligand (FL) in pDC development from common lymphoid progenitors (CLPs)...
  46. pmc Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells
    Brian R Rosborough
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
    J Immunol 192:3470-3. 2014
    The Flt3-Flt3 ligand (Flt3L) pathway is critically involved in the differentiation and homeostasis of myeloid cells, including dendritic cells (DC); however, its role in the expansion and function of myeloid-derived suppressor cells (..
  47. pmc Calcium and calcineurin-NFAT signaling regulate granulocyte-monocyte progenitor cell cycle via Flt3-L
    Jan Fric
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, Singapore
    Stem Cells 32:3232-44. 2014
    ....
  48. pmc Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis
    Nathalie Deckx
    Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute VAXINFECTIO, Antwerp University Hospital, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, Belgium
    Mediators Inflamm 2015:158956. 2015
    ..This may be mediated by Flt3L- and MMP-9-dependent mobilization of DC, as demonstrated by increased circulating levels of Flt3L and MMP-9 ..
  49. pmc Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination
    Mattias N D Svensson
    Department of Rheumatology and Inflammation Research at Sahlgrenska Academy, University of Gothenburg, Gothenburg 41346, Sweden
    Proc Natl Acad Sci U S A 112:E6644-53. 2015
    ..Absence of Flt3 signaling in Flt3 ligand-deficient mice results in impaired IgG1 CSR and accumulation of IgM-secreting plasma cells...
  50. doi Upregulation of Flt3 is a passive event in Hoxa9/Meis1-induced acute myeloid leukemia in mice
    A Staffas
    Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
    Oncogene . 2016
    ..We conclude that the Hoxa9- and Meis1-associated upregulation of Flt3 is not a requirement for leukemic progression induced by Hoxa9 and Meis1.Oncogene advance online publication, 12 September 2016; doi:10.1038/onc.2016.318...
  51. pmc Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, D2024, Cedars Sinai Burns and Allen Research Institute, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Virol 82:9870-9. 2008
    ..We found that immunization of wild-type mice with FMS-like tyrosine kinase 3 ligand (Flt3L) DNA, which increases the number of DCs, increased the amount of latency in infected mice...
  52. doi Nonplasmacytoid, high IFN-α-producing, bone marrow dendritic cells
    Meredith O'Keeffe
    Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia
    J Immunol 188:3774-83. 2012
    ..We propose that these DC constitute a novel bone marrow inflammatory DC type, ideally geared to linking innate and adaptive immune responses in bone marrow via their potent IFN-α production and high T cell stimulatory capacity...
  53. pmc Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice
    Ali Xiong
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    PLoS ONE 7:e46230. 2012
    ..Previous studies demonstrated that the fms-like tyrosine kinase 3 receptor (Flt3) and its ligand (Flt3L) play an essential role in the regulation of DC commitment and development...
  54. pmc Fms-like tyrosine kinase 3 ligand controls formation of regulatory T cells in autoimmune arthritis
    Mattias N D Svensson
    Department of Rheumatology and Inflammation Research at Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    PLoS ONE 8:e54884. 2013
    Fms-like tyrosine kinase 3 ligand (Flt3L) is known as the primary differentiation and survival factor for dendritic cells (DCs). Furthermore, Flt3L is involved in the homeostatic feedback loop between DCs and regulatory T cell (Treg)...
  55. pmc FMS-like tyrosine kinase 3 ligand treatment of mice aggravates acute lung injury in response to Streptococcus pneumoniae: role of pneumolysin
    Christina Brumshagen
    Department of Experimental Pneumology, Hannover Medical School, Hannover, Germany
    Infect Immun 80:4281-90. 2012
    FMS-like tyrosine kinase-3 ligand (Flt3L) is a dendritic cell (DC) growth and differentiation factor with potential in antitumor therapies and antibacterial immunization strategies...
  56. doi Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors
    Ana Pereira de Sousa
    Institut Pasteur, Unité de Lymphopoièse, 75015 Paris, France
    J Immunol 189:3822-30. 2012
    ..This study identifies Id proteins as negative regulators of T cell specification, before B and NK commitment, and provides important insights into the transcriptional networks orchestrating hematopoiesis...
  57. ncbi Identification and characterization of a functional murine FLT3 isoform produced by exon skipping
    C Lavagna
    Laboratoire d Oncologie Moleculaire, INSERM U 119, Marseille, France
    J Biol Chem 270:3165-71. 1995
    ..Ligand-induced tyrosine phosphorylation of the two isoforms was equivalent in COS-1 transfected cells, indicating that the fifth Ig-like domain is not strictly necessary for either ligand-binding or kinase activation...
  58. ncbi Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs
    S D Lyman
    Immunex Research and Development Corporation, Seattle, Washington 98101
    Oncogene 10:149-57. 1995
    We have recently described a novel hematopoietic growth factor, referred to as the flt3 ligand, that stimulates the proliferation of sub-populations of hematopoietic cells that are enriched for stem and progenitor cells...
  59. ncbi Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells
    S D Lyman
    Department of Molecular Genetics, Immunex Research and Development Corp, Seattle, WA 98101
    Blood 83:2795-801. 1994
    Using a fragment of the murine flt3 ligand as a probe, we have succeeded in cloning a human flt3 ligand from a human T-cell lambda gt10 cDNA library. The human and murine ligands are 72% identical at the amino acid level...
  60. ncbi Murine flt3 ligand protects M1 leukemic cells from LIF-induced differentiation and suppression of self-renewal
    C G Begley
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Exp Hematol 24:1247-57. 1996
    ....
  61. ncbi The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand
    F Liu
    Department of Medicine, Washington University Medical School, St Louis, MO 63110 1093, USA
    Blood 90:2522-8. 1997
    ..These results show that the G-CSFR is required for mobilization in response to cyclophosphamide or IL-8 but not flt-3 ligand and suggest that the G-CSFR may play an important and previously unexpected role in HPC migration...
  62. ncbi Flt3 ligand augmentation of T cell mitogenesis and expansion of type 1 effector/memory T cells
    R Lee Mosley
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 7660, USA
    Int Immunopharmacol 2:925-40. 2002
    Herein we report mechanisms whereby Flt3 ligand (FL) augments steady state T cell activity in addition to the expansion of dendritic cells (DCs)...
  63. ncbi Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses
    Brenda J Weigel
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis 55455, USA
    Blood 100:4169-76. 2002
    ..The cytokine Flt3 ligand (Flt3L) also has been shown to generate BM DCs...
  64. ncbi Levels of E2A protein expression in B cell precursors are stage-dependent and inhibited by stem cell factor (c-kit ligand)
    Richard L Riley
    Department of Microbiology and Immunology, University of Miami School of Medicine, PO Box 016960 R138, Miami, FL 33101, USA
    Exp Hematol 30:1412-8. 2002
    ..The expression of E2A protein and mRNA during early B lymphopoiesis was determined and effects of stem cell factor (SCF; Steel factor; c-kit ligand) on E2A expression were evaluated...
  65. ncbi Cytokine gene expression in regenerating haematopoietic tissues of mice after cyclophosphamide treatment
    O Psenak
    Department of Pathophysiology, First Medical School, Charles University, Prague, Czech Republic
    Acta Haematol 109:68-75. 2003
    ..Our findings demonstrate that different cytokines may be involved in the proliferation and mobilization/homing of HPC during recovery after CY damage in BM and spleen...
  66. ncbi Murine Flt3 ligand expands distinct dendritic cells with both tolerogenic and immunogenic properties
    George Miller
    Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 170:3554-64. 2003
    Human Flt3 ligand can expand dendritic cells (DC) and enhance immunogenicity in mice. However, little is known about the effects of murine Flt3 ligand (mFlt3L) on mouse DC development and function...
  67. ncbi Phosphatidylinositol 3-kinase is essential for kit ligand-mediated survival, whereas interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes
    Richard Karlsson
    Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmo, Sweden
    J Leukoc Biol 74:923-31. 2003
    Cytokines such as interleukin 3 (IL-3), kit ligand (KL), and flt3 ligand (FL) promote survival of hematopoietic stem cells and myeloid progenitor cells...
  68. ncbi Differential roles for IL-15R alpha-chain in NK cell development and Ly-49 induction
    Toshihiko Kawamura
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 171:5085-90. 2003
    ..when bone marrow (BM) progenitors from IL-15Ralpha(-/-) mice were cultured with IL-7, stem cell factor and flt3 ligand, followed by IL-15, they were able to differentiate into functional NK cells, indicating that IL-15Ralpha is ..
  69. ncbi Flt3 ligand preferentially increases the number of functionally active myeloid dendritic cells in the lungs of mice
    Barbara J Masten
    Department of Pathology, University of New Mexico, Albuquerque, NM 87131, USA
    J Immunol 172:4077-83. 2004
    In the present study, we investigated the effects of in vivo Flt3L administration on the generation, phenotype, and function of lung dendritic cells (DCs) to evaluate whether Flt3L favors the expansion and maturation of a particular DC ..
  70. ncbi Flt-3 ligand reverses late allergic response and airway hyper-responsiveness in a mouse model of allergic inflammation
    Jehad H Edwan
    Department of Medical Microbiology and Immunology, and Center for Allergy, Asthma, and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Immunol 172:5016-23. 2004
    b>Flt3 ligand (Flt3-L) is a growth factor for dendritic cells and induces type 1 T cell responses...
  71. ncbi Flt3-ligand treatment prevents diabetes in NOD mice
    Paula M Chilton
    Institute for Cellular Therapeutics, University of Louisville, Louisville, Kentucky 40202 1760, USA
    Diabetes 53:1995-2002. 2004
    ..Therefore, Flt3-ligand treatment and/or the establishment of mixed chimerism in prediabetic candidates may provide a benign and novel approach to treat diabetes...
  72. ncbi Treatment with Flt3 ligand plasmid reverses allergic airway inflammation in ovalbumin-sensitized and -challenged mice
    Jehad H Edwan
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, CRISS I Room 131, 2500 California Plaza, Omaha, NE 68178, USA
    Int Immunopharmacol 5:345-57. 2005
    ..05). Total BALF cellularity, eosinophiles counts and BALF IL-5 levels were also reduced (P<0.01). pUMVC3-hFLex treatment can reverse established experimental asthma and might provide a novel approach for treating asthma...
  73. ncbi Inhibition of natural type I IFN-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity
    Roxane Tussiwand
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Immunol 175:3674-80. 2005
    ..and DC progenitors and their respective downstream cell populations express the flt3 receptor, and Flt3 ligand (Flt3L)(-/-) mice have reduced while Flt3L-injected mice develop markedly increased numbers of both cell types...
  74. ncbi The long-term but not the short-term antiviral effect of IFN-alpha depends on Flt3 ligand and pDC
    Sabine Vollstedt
    Institute for Virology, University of Zurich, Zurich, Switzerland
    Eur J Immunol 36:1231-40. 2006
    ..The transfer of pDC to mice lacking FL enhanced viral resistance. Therefore, the induction and function of pDC, normally controlled by IFN-alpha/beta and FL, are decisive for viral resistance in neonatal mice...
  75. pmc Distinct roles of IL-7 and stem cell factor in the OP9-DL1 T-cell differentiation culture system
    Hongfang Wang
    Department of Pathology, The University of Utah, Salt Lake City, Utah 84132 2022, USA
    Exp Hematol 34:1730-40. 2006
    ..We examined the roles played by IL-7, Flt3 ligand, and stem cell factor (SCF) in differentiation of adult bone marrow cells in the OP9-DL1 culture system.
  76. ncbi Disease-modifying capability of murine Flt3-ligand DCs in experimental autoimmune encephalomyelitis
    Tracey L Papenfuss
    Departments of Veterinary Biosciences, The Ohio State University, 370 Veterinary Medical Academic Building, 1900 Coffey Road, Columbus, OH 43210, USA
    J Leukoc Biol 82:1510-8. 2007
    ..These immature mFL DCs up-regulated costimulatory molecules in response to maturation stimuli LPS and TNF-alpha. Mature mFL BM-DCs were immunogenic and exacerbated the clinical disease course of EAE...
  77. ncbi Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development
    Christina T Jensen
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 111:2083-90. 2008
    ..However, we demonstrate that, whereas thymopoiesis is abolished in adult mice doubly deficient in IL-7 and FLT3 ligand (FLT3L), TSLP does not play a key role in IL-7-independent or FLT3L-independent T lymphopoiesis...
  78. doi FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis
    Christina T Jensen
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 112:2297-304. 2008
    ..Here we demonstrate that, rather than TSLP, IL-7 and FLT3 ligand are combined responsible for all B-cell generation in mice, including recently identified B-1-specified cell ..
  79. ncbi Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development
    Min Cheng
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    J Immunol 182:1460-8. 2009
    ..gamma-chain (Il2rg) essential for IL-15-induced signaling, and FMS-like tyrosine kinase 3 (FLT3) receptor ligand (Flt3l) were previously identified as important regulatory pathways of the BM NK cell compartment based on lack of ..
  80. doi Homeostasis of dendritic cells in lymphoid organs is controlled by regulation of their precursors via a feedback loop
    Kristin Hochweller
    Division of Molecular Immunology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Blood 114:4411-21. 2009
    ..This mechanism is different to those known for other immune cell types, such as the B- and T-cell compartments, whereby lymphopenia induces proliferation of already differentiated lymphocytes...
  81. doi Accumulation of DC in lamina propria induced by FMS-like tyrosine kinase 3 ligand aggravates the intestinal inflammatory response during endotoxemia
    Xiao song Xiang
    Research Institute of General Surgery, Clinical School of Nanjing, Second Military Medical University, Jinling Hospital, Nanjing 210002, Jiangsu Province, China
    Inflammation 33:34-45. 2010
    ..improve protective immunity to bacterial translocation and outcome in endotoxemic mice, we pre-treated mice with Flt3L or normal saline, and then challenged them with or without LPS...
  82. doi Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis
    Linda Kenins
    Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Eur J Immunol 40:81-90. 2010
    ..After irradiation-induced thymic damage, thymic recovery is facilitated by Flt3 ligand (FL), expressed by perivascular fibroblasts surrounding the thymic entry site of Flt3 receptor-positive ..
  83. doi Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia
    Michael Heuser
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Exp Hematol 38:174-9. 2010
    ..To test whether the microenvironment impacts on leukemic phenotype, we exploited the MN1 model of acute myeloid leukemia under defined genetically modified microenvironmental conditions...
  84. pmc Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology
    Daniel Larocque
    Gene Therapeutics Research Institute, Cedars Sinai Biomedical Sciences Graduate Program, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 107:14443-8. 2010
    ..We tested the prediction that expression of fms-like tyrosine kinase ligand 3 (Flt3L) in the brain will recruit dendritic cells and induce a systemic immune response against exogenous influenza ..
  85. pmc Dendritic cell modification of neutrophil responses to infection after burn injury
    Julia Bohannon
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 0591, USA
    J Immunol 185:2847-53. 2010
    ..We have found that prophylactic treatment of burn-injured mice with the DC growth factor FLT3 ligand (FL) significantly increases resistance to burn wound infections in a DC-dependent manner that is correlated ..
  86. doi Bcl6 is required for the development of mouse CD4+ and CD8α+ dendritic cells
    Hiromi Ohtsuka
    Department of Developmental Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 186:255-63. 2011
    ..These results suggest that Bcl6 is required in cDC precursors for survival and in activated DCs for modulating the cytokine profile...
  87. pmc Plasmacytoid dendritic cell dichotomy: identification of IFN-α producing cells as a phenotypically and functionally distinct subset
    Pia Björck
    Department of Pathology, Stanford University, Palo Alto, CA 94304, USA
    J Immunol 186:1477-85. 2011
    ..We propose that newly generated pDC mobilized from the bone marrow, rather than tissue-resident pDC, are the major source of IFN-α in infected hosts...
  88. doi Flt3L-mobilized dendritic cells bearing H2-Kbm1 apoptotic cells do not induce cross-tolerance to CD8+ T cells across a class I MHC mismatched barrier
    Maria Luisa del Rio
    Immunobiology Section, Institute of Biomedicine, University of Leon, Leon, Spain
    Transpl Int 24:501-13. 2011
    ..Rag2/γ(c) KO B6 mice were treated with Fms-like tyrosine kinase 3 ligand (Flt3L)-transduced B16 melanoma cells to drive a rapid expansion and mobilization of DC in vivo...
  89. doi Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production
    Daisuke Sugiyama
    Division of Hematopoietic Stem Cells, Advanced Medical Initiatives, Department of Advanced Medical Initiatives, Kyushu University Faculty of Medical Sciences, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 410:301-6. 2011
    ..Our observations demonstrate that hepatoblasts comprise a niche for erythropoiesis through cytokine secretion...
  90. doi Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation
    Shabnam Kharazi
    Hematopoietic Stem Cell Laboratory, Lund Stem Cell Center, Lund University Biomedical Center, Lund, Sweden
    Blood 118:3613-21. 2011
    ..Further, whereas autocrine FLT3 ligand production has been implicated in FLT3-ITD myeloid malignancies and resistance to FLT3 inhibitors, we ..
  91. ncbi Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice
    K Brasel
    Department of Immunobiology, Immunex Corporation, Seattle, WA 98101, USA
    Blood 90:3781-8. 1997
    ..We investigated the capacity of several different growth factors, including human flt3 ligand (FL), alone and in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF ) or granulocyte ..
  92. ncbi Heart, but not skin, allografts from donors lacking Flt3 ligand exhibit markedly prolonged survival time
    Zhiliang Wang
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Immunol 172:5924-30. 2004
    Fms-like tyrosine kinase 3 ligand (Flt3L) administration leads to dramatic increases in dendritic cells (DC) in lymphoid and nonlymphoid tissues...
  93. ncbi Hosts lacking fms-like tyrosine kinase 3 ligand exhibit marked reductions in transplant vascular sclerosis
    Zhiliang Wang
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    Transplantation 79:869-75. 2005
    Mice lacking fms-like tyrosine kinase 3 ligand (Flt3L-/-) as the result of targeted gene disruption show severe reductions in dendritic cell (DC) subsets...
  94. pmc Flt3 ligand generates morphologically distinct semimature dendritic cells in ovalbumin-sensitized mice
    Arpita S Bharadwaj
    Department of Medical Microbiology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Exp Mol Pathol 83:17-24. 2007
    ..Intermediate to these two groups are the DCs in the Flt3 ligand-treated group that exhibit comparatively fewer dendrites and cytoplasmic veils and hence are classified as ..
  95. pmc Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation
    Linda Kenins
    Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland
    J Exp Med 205:523-31. 2008
    ..We used the BM transplant model to investigate the importance of Flt3 ligand (FL) for the regeneration of the T cell compartment...
  96. pmc Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:4004-9. 2008
    ..Finally, differentiating bmEos are readily transfected with lentiviral vectors, suggesting a means for rapid production of genetically manipulated cells...
  97. doi FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells
    Natalija Buza-Vidas
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 113:3453-60. 2009
    ..Taken together, these studies show that the FLT3 receptor and ligand are not critical regulators of mouse HSCs, neither in steady state nor during fetal or posttransplantation expansion...
  98. pmc Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme
    Keisuke Horiuchi
    Department of Anti aging Orthopedic Research, Keio University, School of Medicine, Shinjuku ku, Tokyo, Japan
    J Immunol 182:7408-14. 2009
    b>FLT3 ligand (FLT3L) has diverse roles in the hematopoietic system, which include stimulating proliferation of hematopoietic precursors and development of NK cells and dendritic cells...
  99. pmc Endogenous Fms-like tyrosine kinase-3 ligand levels are not altered in mice after a severe burn and infection
    Julia K Bohannon
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA
    BMC Immunol 10:47. 2009
    Fms-like tyrosine kinase-3 ligand (Flt3L) is a hemopoietic cytokine and dendritic cell (DC) growth factor that promotes the proliferation and differentiation of progenitor cells into DCs...
  100. doi Fms-like tyrosine kinase 3 ligand regulates migratory pattern and antigen uptake of lung dendritic cell subsets in a murine model of allergic airway inflammation
    Zhifei Shao
    Department of Biomedical Sciences, Creighton University of School of Medicine, Omaha, NE 68178, USA
    J Immunol 183:7531-8. 2009
    Fms-like tyrosine kinase 3 ligand (Flt3L) reverses the features of allergic airway inflammation and increases a Th2-suppressive regulatory lung CD11c(high)CD11b(low) dendritic cell (DC) subset in a mouse model...
  101. ncbi Molecular cloning of canine and feline flt3 ligand reveals high degree of similarity to the human and mouse homologue but uniquely long cytoplasmic domain
    S Yang
    Heska Corporation, Fort Collins, CO 80525, USA
    DNA Seq 11:163-6. 2000
    The cDNAs encoding canine and feline flt3 ligand (FL) have been isolated from libraries constructed from canine or feline peripheral blood mononuclear cells and sequenced...

Research Grants3

  1. SENESCENE AND PREB CELL DEVELOPMENT
    Richard Riley; Fiscal Year: 2003
    ..The experiments in this application will provide a cellular and molecular basis for understanding the temporal loss of B lymphopoiesis and altered generation of VH repertoire during senescence. ..
  2. Neuroprotective Vaccination for Parkinson's Disease
    R Mosley; Fiscal Year: 2005
    ..These approaches could prove useful for treatment of human PD. ..
  3. Regulation of E2A in Normal and Aged B Lymphopoiesis
    Richard Riley; Fiscal Year: 2008
    ..More broadly, these studies will further our understanding of the immune defects which accompany old age and their cellular and molecular mechanisms. ..