Fgf8

Summary

Gene Symbol: Fgf8
Description: fibroblast growth factor 8
Alias: Aigf, Fgf-8, fibroblast growth factor 8, HBGF-8, androgen-induced growth factor, heparin-binding growth factor 8
Species: mouse

Top Publications

  1. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
  2. ncbi Neocortex patterning by the secreted signaling molecule FGF8
    T Fukuchi-Shimogori
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA
    Science 294:1071-4. 2001
  3. ncbi Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling
    Katherine Shim
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, California 94143, USA
    Dev Cell 8:553-64. 2005
  4. ncbi The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
    Candace L Chi
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Development 130:2633-44. 2003
  5. pmc Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning
    Francesca V Mariani
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California 94158 2324, USA
    Nature 453:401-5. 2008
  6. ncbi Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb
    Ying Liu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Development 129:5289-300. 2002
  7. pmc Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice
    Yasuhiko Kawakami
    Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Development 138:4465-73. 2011
  8. ncbi A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo
    T P Yamaguchi
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    Development 126:1211-23. 1999
  9. ncbi Isl1Cre reveals a common Bmp pathway in heart and limb development
    Lei Yang
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Development 133:1575-85. 2006
  10. ncbi Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud
    Kazushi Aoto
    Molecular Neuropathology Group, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 251:320-32. 2002

Research Grants

  1. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
  2. Conditional gene trapping
    SUZANNE MANSOUR; Fiscal Year: 2004
  3. Body Plan Formation in Early Mouse Embryo
    Yusuke Marikawa; Fiscal Year: 2004
  4. Role of Gbx2 and Otx2 in the mes-met organizer function
    James Li; Fiscal Year: 2003
  5. The Ciona savignyi Genetic Map
    Arend Sidow; Fiscal Year: 2008
  6. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009
  7. Mutagenesis of Tbx3: a model of ulnar-mammary syndrome
    Anne M Moon; Fiscal Year: 2010
  8. REGIONAL DIFFERENTIATION DURING FOREBRAIN DEVELOPMENT
    Anthony S LaMantia; Fiscal Year: 2010
  9. CONDITIONAL MUTAGENESIS OF FIBROBLAST GROWTH FACTORS
    Anne Moon; Fiscal Year: 2002
  10. GENETIC ANALYSIS OF EARLY LIMB DEVELOPMENT
    Arend Sidow; Fiscal Year: 2004

Detail Information

Publications202 found, 100 shown here

  1. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
    ..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
  2. ncbi Neocortex patterning by the secreted signaling molecule FGF8
    T Fukuchi-Shimogori
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA
    Science 294:1071-4. 2001
    ..Here we provide evidence that FGF8 regulates development of the map from a source in the anterior telencephalon...
  3. ncbi Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling
    Katherine Shim
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, California 94143, USA
    Dev Cell 8:553-64. 2005
    ..Both this cell fate change and hearing loss can be partially rescued by reducing Fgf8 gene dosage in Spry2 null mutant mice...
  4. ncbi The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
    Candace L Chi
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Development 130:2633-44. 2003
    ..b>FGF8 and WNT1 have been implicated as key components of IsO signaling activity, and previous studies have shown that in ..
  5. pmc Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning
    Francesca V Mariani
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California 94158 2324, USA
    Nature 453:401-5. 2008
    ..Fibroblast growth factor (FGF) gene family members are key AER-derived signals, with Fgf4, Fgf8, Fgf9 and Fgf17 expressed specifically in the mouse AER...
  6. ncbi Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb
    Ying Liu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Development 129:5289-300. 2002
    Proximal-to-distal growth of the embryonic limbs requires Fgf10 in the mesenchyme to activate Fgf8 in the apical ectodermal ridge (AER), which in turn promotes mesenchymal outgrowth...
  7. pmc Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice
    Yasuhiko Kawakami
    Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Development 138:4465-73. 2011
    ..Our data demonstrate that Islet1 and β-catenin regulate outgrowth and Fgf10-Fgf8 feedback loop formation during vertebrate hindlimb initiation...
  8. ncbi A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo
    T P Yamaguchi
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    Development 126:1211-23. 1999
    ..The reduced number of proliferating cells in both the progress zone and the primitive streak mesoderm suggests that one function of Wnt5a is to regulate the proliferation of progenitor cells...
  9. ncbi Isl1Cre reveals a common Bmp pathway in heart and limb development
    Lei Yang
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Development 133:1575-85. 2006
    ..Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome. We provide evidence that the Tbx3 promoter is directly regulated by Bmp Smads in vivo...
  10. ncbi Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud
    Kazushi Aoto
    Molecular Neuropathology Group, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 251:320-32. 2002
    ..We observed an up-regulation of Fgf8 in the anterior neural ridge, isthmus, eye, facial primordia, and limb buds of mutant embryos, sites coinciding ..
  11. ncbi New semidominant mutations that affect mouse development
    Debora Bogani
    Laboratory of Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX111 0RD, UK
    Genesis 40:109-117. 2004
    ..In one coat spotting mutant the homozygous condition is lethal before neural crest cell production commences. The mutated genes often function in processes additional to those alluded to by the heterozygous phenotype...
  12. ncbi Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea
    Bonnie E Jacques
    Section on Developmental Neuroscience, Porter Neuroscience Research Center, 35 Convent Dr, Room 2A 100, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Development 134:3021-9. 2007
    ..Here, using in vitro and in vivo techniques, we demonstrate that an Fgf8 signal arising from the inner hair cells is the key component in an inductive pathway that regulates the number, ..
  13. doi Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation
    Nicholas Warr
    Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 17:2986-96. 2008
    ..The analysis provides genetic evidence that Zic2 functions during organizer formation and that the PCP develops via a multi-step process...
  14. pmc Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development
    Chen Wang
    Department of Urology, Children s Hospital Boston, 300 Longwood Avenue, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 360:186-94. 2011
    ..Thus, Six1 and Eya1 are key regulators of both upper and lower urinary tract morphogenesis. Results from this study uncover essential roles of the PCM progenitors during genitourinary tract formation...
  15. pmc An obligatory role of mind bomb-1 in notch signaling of mammalian development
    Bon Kyoung Koo
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea
    PLoS ONE 2:e1221. 2007
    ..However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood...
  16. ncbi Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region
    Markus Panhuysen
    Institute of Developmental Genetics, GSF Research Center for Environment and Health, 85764 Neuherberg, Germany
    Mol Cell Neurosci 26:101-11. 2004
    ..We suggest that Wnt1 acts as a regulator of proliferation of specific precursor populations in the developing mid-/hindbrain region and is only secondarily involved in maintenance of the mid-/hindbrain organizer...
  17. ncbi Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
    X Sun
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California, USA
    Nat Genet 25:83-6. 2000
    ..We also found that maintenance of Fgf9 and Fgf17 expression is dependent on Shh, whereas Fgf8 expression is not...
  18. ncbi Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region
    Wei Lin
    Medical Research Council, National Institute for Medical Research, London, UK
    Genesis 41:110-5. 2005
    ..Altogether, our results demonstrate that Sef and Sproutys function synergistically to regulate Gbx2 expression in the anterior hindbrain...
  19. pmc The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure
    Jinzhe Mao
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Development 137:3079-88. 2010
    ..Finally, we demonstrate that this loss of forebrain maintenance is due in part to the iron deficiency that results from the absence of fully functional Fpn1...
  20. doi The canonical Wnt/β-catenin signaling pathway regulates Fgf signaling for early facial development
    Yongping Wang
    Department of Cell Biology and Human Anatomy, University of California, Davis, Sacramento, CA 95817, USA
    Dev Biol 349:250-60. 2011
    ..Gene expression of several cell-survival and patterning factors, including Fgf8, Fgf3, and Fgf17, is dramatically diminished in the anterior neural ridge (ANR, a rostral signaling center) and/or ..
  21. pmc Ectodermal Wnt/β-catenin signaling shapes the mouse face
    Bethany S Reid
    Department of Craniofacial Biology and Cell and Developmental Biology, University of Colorado Denver, 12801 East 17th Avenue, PO Box 6511, Aurora, CO 80045, USA
    Dev Biol 349:261-9. 2011
    ..There are accompanying alterations in the expression of Fgf8 and Shh, key molecules that establish a signaling center critical for facial patterning, the frontonasal ectodermal ..
  22. pmc The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch
    Neil T Sheehy
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 137:4307-16. 2010
    ..expression in Dicer mutant pharyngeal arches, and regulated non-cell-autonomous signaling involving Wnt5a, Shh and Fgf8 that converged on Dlx2 regulation in PA1...
  23. doi Nuclear translocation of FGF8 and its implication to induce Sprouty2
    Ayumu Suzuki
    Department of Molecular Neurobiology, Graduate School of Life Sciences and Institute of Development, Aging and Cancer, Tohoku University, Seiryo machi 4 1, Aoba ku, 980 8575 Sendai, Japan
    Dev Growth Differ 54:463-73. 2012
    b>Fibroblast growth factor 8 (FGF8) functions as a local organizing signal for the tectum and cerebellum. FGF8 activates Ras-ERK signaling pathway to induce cerebellar development...
  24. ncbi The mouse Engrailed-1 gene and ventral limb patterning
    C A Loomis
    Ronald O Perelman Deparment of Dermatology, New York University Medical School 10016, USA
    Nature 382:360-3. 1996
    ..Engrailed-1 seems to act in part by repressing dorsal differentiation induced by Wnt-7a, and is essential for proper formation of the apical ectodermal ridge...
  25. ncbi Genetic control of brain morphogenesis through Otx gene dosage requirement
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Development 124:3639-50. 1997
    ....
  26. ncbi Fgf-8 determines rostral-caudal polarity in the first branchial arch
    A S Tucker
    Department of Craniofacial Development, UMDS Guy s Hospital, London SE1 9RT, UK
    Development 126:51-61. 1999
    ....
  27. pmc Fgf8 is required for outgrowth and patterning of the limbs
    A M Moon
    Department of Pediatrics and Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Nat Genet 26:455-9. 2000
    The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of ..
  28. ncbi Unique functions of Sonic hedgehog signaling during external genitalia development
    R Haraguchi
    Center for Animal Resources and Development CARD and Graduate School of Molecular and Genomic Pharmacy, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Development 128:4241-50. 2001
    ..These results suggest a dual mode of Shh function, first by the regulation of initiating GT outgrowth, and second, by subsequent GT differentiation...
  29. ncbi Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    Wei Zhang
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Cell 10:657-65. 2006
    ..Specific Cdo domains required for its promyogenic effect are dispensable for its Shh signaling role, suggesting that Cdo has multiple, independent functions...
  30. ncbi Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4
    Kentaro Suzuki
    Center for Animal Resources and Development, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Eur J Hum Genet 16:36-44. 2008
    ..These results suggest that different genes associated with human SHFM could also be involved in the aetiogenesis of hypospadias pointing toward a common molecular origin of these congenital malformations...
  31. doi Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb
    Yvan Lallemand
    CNRS URA, Institut Pasteur, Paris, France
    Dev Biol 331:189-98. 2009
    ....
  32. pmc Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice
    Victoria Randall
    Molecular Medicine Unit, Institute of Child Health, London, United Kingdom
    J Clin Invest 119:3301-10. 2009
    ..We could not rescue PAA morphogenesis by restoring neural crest Chd7 expression. Rather, biallelic expression of Chd7 and Tbx1 in the pharyngeal ectoderm was required for normal PAA development...
  33. doi Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis
    Kazushi Aoto
    Molecular Neuropathology Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 327:106-20. 2009
    ..These findings provide new insight into the mechanism underlying HPE pathoetiology during dynamic brain and craniofacial morphogenesis...
  34. pmc Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood
    Xiu Ping Wang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Development 136:1939-49. 2009
    ..In addition, we identify Fgf8, a known tooth initiation marker, as a direct target of Wnt/beta-catenin signaling...
  35. pmc Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development
    Frances A High
    Department of Cell and Developmental Biology, Cardiovascular Institute, and Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Clin Invest 119:1986-96. 2009
    ..In mid-gestation, these mutants displayed decreased Fgf8 and Bmp4 expression. Notch inhibition within the second heart field affected the development of neighboring tissues...
  36. ncbi An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
    E N Meyers
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Nat Genet 18:136-41. 1998
    ..The 'allelogenic' mouse line we produced carries a hypomorphic allele of Fgf8, which can be converted to a null allele by mating to cre transgenic animals...
  37. pmc Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
    R Jiang
    The Jackson Laboratory, Bar Harbor, Maine 04609 USA
    Genes Dev 12:1046-57. 1998
    ..ridge (AER) of the limb buds of the mutant homozygotes is hyperplastic, and we observe an expanded domain of Fgf8 expression in the AER...
  38. ncbi The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice
    E A Grove
    Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, IL, USA
    Development 125:2315-25. 1998
    ....
  39. doi Shh dependent and independent maintenance of basal midbrain
    Ariadna Perez-Balaguer
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Mech Dev 126:301-13. 2009
    ..Based on our results and recently published data, we suggest the existence of a specific genetic pathway for the specification of the mesencephalic red nucleus. Foxa2 could be the candidate gene that might control this genetic pathway...
  40. doi Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion
    Lanying Song
    Department of Cell Biology and Human Anatomy, University of California, Davis, CA 95616, USA
    Development 136:3161-71. 2009
    ..Thus, the Lrp6-mediated Wnt signaling pathway is required for lip development by orchestrating two distinctively different morphogenetic movements...
  41. ncbi The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo
    P H Crossley
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco 94143 0452, USA
    Development 121:439-51. 1995
    ..In this report, we provide a detailed analysis of the mouse Fgf8 gene...
  42. ncbi Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development
    M Grigoriou
    Division of Developmental Neurobiology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 125:2063-74. 1998
    ..Furthermore, expression studies and bead implantation experiments in vitro have provided strong evidence that Fgf8 is primarily responsible for the restricted expression of Lhx6 and Lhx7 in the oral aspect of the maxillary and ..
  43. ncbi Experimental analysis of the emergence of left-right asymmetry of the body axis in early postimplantation mouse embryos
    T E Tsang
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Cell Mol Biol (Noisy-le-grand) 45:493-503. 1999
    ..in the early gastrula shows that there is a transient asymmetric localization of the transcripts of Cerrl, Fgf8, Hesx1 and Hnf3beta gene in the anterior visceral endoderm, Otx2 and Sox2 in the epiblast and Lim1 in the nascent ..
  44. ncbi The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation
    J P Martinez Barbera
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    Development 127:2433-45. 2000
    ..All together, these results demonstrate that Hex function is essential in definitive endoderm for normal development of the forebrain, liver and thyroid gland...
  45. pmc Fgfr1 regulates patterning of the pharyngeal region
    Nina Trokovic
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Genes Dev 17:141-53. 2003
    ..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
  46. ncbi The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis
    R Andrea DeYoung
    Department of Molecular and Cell Biology, Division of Immunology, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    J Biol Chem 278:47104-9. 2003
    ..Abnormal expression of a number of early developmental markers and defects in growth or distribution of emerging mesoderm cells were also detected. These data suggest that Nor-1 plays a crucial role in gastrulation...
  47. doi Fibroblast growth factor 8 induced downregulation of thrombospondin 1 is mediated by the MEK/ERK and PI3K pathways in breast cancer cells
    Kati Tarkkonen
    Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, 20520, Turku, Finland
    Growth Factors 28:256-67. 2010
    Expression of fibroblast growth factor 8 (FGF-8) is increased in several forms of hormonal cancer. It was previously shown to regulate expression of thrombospondin 1 (TSP-1), an inhibitor of angiogenesis, in S115 breast cancer cells...
  48. doi Msx1 and Msx2 in limb mesenchyme modulate digit number and identity
    Vardina Bensoussan-Trigano
    Institut Pasteur, Génétique Moléculaire de la Morphogenèse, CNRS URA 2578, Paris, France
    Dev Dyn 240:1190-202. 2011
    ..With this strategy, we demonstrate that mesenchymal expression of Msx1 and Msx2 is required for proper Shh and Bmp4 signaling to specify digit number and identity...
  49. pmc α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice
    Amparo Girós
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Burjassot, Spain
    PLoS ONE 6:e22002. 2011
    ..Thus, α5β1-mediated adhesion to FN in the PSM regulates the dynamics of membrane protrusions and cell-to-cell communication essential for elongation and segmentation of the body axis...
  50. ncbi Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed
    G Minowada
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, CA 94143 0452, USA
    Development 126:4465-75. 1999
    ....
  51. pmc Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice
    Bart van De Sluis
    Laboratory of Metabolic and Endocrine Diseases, Room KC 02 069 1, UMC Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Mol Cell Biol 27:4142-56. 2007
    ..Thus, this study identifies COMMD1 as a novel regulator of HIF-1 activity and shows that Commd1 deficiency in mice leads to embryonic lethality associated with dysregulated placenta vascularization...
  52. doi A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning
    Jean Denis Bénazet
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Science 323:1050-3. 2009
    ..This self-regulatory signaling network results in robust regulation of distal limb development that is able to compensate for variations by interconnectivity among the three signaling pathways...
  53. doi Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb
    Natalie C Butterfield
    The University of Queensland, Institute for Molecular Bioscience, Queensland, Australia
    Development 136:3515-24. 2009
    ..These results establish the importance of the downstream consequences of Hh pathway repression, and identify Ptc1 as a key player in limb patterning even prior to the onset of Shh expression...
  54. pmc beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region
    Dmitri Chilov
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    PLoS ONE 5:e10881. 2010
    ..mouse midbrain-rhombomere 1 region leads to robust up-regulation of several Wnt signalling target genes, including Fgf8. Suggestive of direct transcriptional regulation of the Fgf8 gene, beta-catenin stabilization resulted in Fgf8 up-..
  55. pmc Essential roles of fibronectin in the development of the left-right embryonic body plan
    Maria V Pulina
    Weill Cornell Medical College, Department of Medicine, Division of Cardiology, New York, NY, USA
    Dev Biol 354:208-20. 2011
    ..Taken together, our studies demonstrate the requisite role for a structural ECM protein and its integrin receptor in the development of the left-right axis of asymmetry in vertebrates...
  56. ncbi Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8
    W Ye
    Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Neurosci 4:1175-81. 2001
    Local expression of FGF8 at the mid/hindbrain boundary (MHB) governs the development of multiple neurons and support cells...
  57. ncbi Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants
    J A Cygan
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Development 124:5021-32. 1997
    ..Unlike the normal AER, ectopic AER formation is dependent upon Wnt-7a activity, indicating that distinct genetic mechanisms may be involved in primary and secondary AER formation...
  58. ncbi Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs
    C A Loomis
    Ronald O Perelman Department of Dermatology, NYU Medical School, New York, NY 10016, USA
    Development 125:1137-48. 1998
    ..This leads to induction of a second zone of compaction ventrally, which in some cases goes on to form an autonomous secondary AER...
  59. ncbi Teeth. Where and how to make them
    H Peters
    GSF Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany
    Trends Genet 15:59-65. 1999
    ..This cascade provides a molecular model by which reciprocal tissue interactions are controlled...
  60. pmc Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    A Trumpp
    G W Hooper Foundation, Department of Microbiology, School of Medicine, University of California at San Francisco UCSF, San Francisco, California 94143 0552, USA
    Genes Dev 13:3136-48. 1999
    ..Here we used Cre/loxP technology to inactivate the mouse Fgf8 gene in this ectoderm and have obtained genetic evidence that FGF8 has a dual function in BA1: it promotes ..
  61. ncbi Nodal signalling in the epiblast patterns the early mouse embryo
    J Brennan
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 411:965-9. 2001
    ..Our experiments show that proximal-distal and subsequent anterior-posterior polarity of the pregastrulation embryo result from reciprocal cell-cell interactions between the epiblast and the two extra-embryonic tissues...
  62. ncbi Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
    C Chiang
    Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Dev Biol 236:421-35. 2001
    ..the architecture of the Shh(-/-) AER is gradually disrupted over developmental time in parallel with a reduction of Fgf8 expression in the ridge...
  63. ncbi Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR
    P P Boyl
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, New Hunt s House, London SE1 1UL, UK
    Development 128:2989-3000. 2001
    ..This leads us to hypothesise that this control might have important evolutionary implications...
  64. ncbi OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation
    D Acampora
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, New Hunts House, London SE1 9RT, UK
    Development 128:4801-13. 2001
    ..These data provide novel in vivo evidence supporting the concept that during evolution pre-existing gene functions have been recruited into new developmental pathways by modifying their regulatory control...
  65. ncbi Otx2 is required to respond to signals from anterior neural ridge for forebrain specification
    E Tian
    Department of Morphogenesis, Kumamoto University, Honjo 2 2 1, Kumamoto, 860 0811, Japan
    Dev Biol 242:204-23. 2002
    ..These results further suggest that Otx2 dosage may be crucial in the neural plate with respect to response to inductive signals primarily from the ANR for forebrain specification...
  66. ncbi FGFR1 is required for the development of the auditory sensory epithelium
    Ulla Pirvola
    Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
    Neuron 35:671-80. 2002
    ..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium...
  67. ncbi Extraembryonic proteases regulate Nodal signalling during gastrulation
    Séverine Beck
    Developmental Biology Group, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Cell Biol 4:981-5. 2002
    ..A lack of Spc1 and Spc4 affects both pathways because these proteases also stimulate induction of Bmp4...
  68. ncbi Wnt3a plays a major role in the segmentation clock controlling somitogenesis
    Alexander Aulehla
    Abteilung Entwicklungsbiologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108, Freiburg, Germany
    Dev Cell 4:395-406. 2003
    ..We propose that the segmentation clock is established by Wnt/beta-catenin signaling via a negative-feedback mechanism and that Wnt3a controls the segmentation process in vertebrates...
  69. ncbi Emx2 patterns the neocortex by regulating FGF positional signaling
    Tomomi Fukuchi-Shimogori
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, 947 East 58th Street, MC0926, Chicago, Illinois 60637, USA
    Nat Neurosci 6:825-31. 2003
    Molecular genetic studies implicate fibroblast growth factor 8 (FGF8), and the transcription factor Emx2, in development of the neocortical area map...
  70. pmc Sp8 is crucial for limb outgrowth and neuropore closure
    Sheila M Bell
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 100:12195-200. 2003
    ..These observations indicate that Sp8 functions downstream of Wnt3, Fgf10, and Bmpr1a in the signaling cascade that mediates AER formation...
  71. ncbi Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse
    Alexandra A Blak
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany
    Dev Dyn 233:1023-30. 2005
    b>Fibroblast growth factor 8 (FGF8) mediates the function of the midbrain-hindbrain organizer (MHO). FGF signals are transmitted by means of four known FGF receptors (FGFRs)...
  72. pmc The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
    Johanna Mantela
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 132:2377-88. 2005
    ..Our findings demonstrate that the pRb pathway is required for hair cell quiescence and that manipulation of the cell cycle machinery disrupts the coordinated development within the inner ear sensory epithelia...
  73. ncbi Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development
    Zhen Zhang
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:5307-15. 2005
    ..We also thereby demonstrate conclusively that the role of Tbx1 in fourth PAA development is cell non-autonomous...
  74. ncbi Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum
    Shubha Tole
    Department of Biological Sciences, Room B304, Tata Institute of Fundamental Research, Colaba, Mumbai, India
    Dev Biol 289:141-51. 2006
    ....
  75. ncbi Regulation of osteoblast differentiation: a novel function for fibroblast growth factor 8
    Maija P Valta
    Institute of Biomedicine, Department of Anatomy, University of Turku, Finland
    Endocrinology 147:2171-82. 2006
    ..The results suggest that FGF-8, which is expressed by a great proportion of malignant breast and prostate tumors, may, among other factors, also be involved in the formation of osteosclerotic bone metastases...
  76. ncbi LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1
    Alexandra Capela
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Dev Biol 291:300-13. 2006
    ..These regions also express high levels of the growth factors FGF8 and/or Wnt-1. We show here that LeX-containing molecules in the developing nervous system bind Wnt-1...
  77. ncbi Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
    Elaine E Storm
    Department of Anatomy, University of California, San Francisco, CA 94143 2711, USA
    Development 133:1831-44. 2006
    Mouse embryos bearing hypomorphic and conditional null Fgf8 mutations have small and abnormally patterned telencephalons...
  78. ncbi The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4
    Nadav Ben-Haim
    Ecole Polytechnique Fédérale de Lausanne EPFL ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Dev Cell 11:313-23. 2006
    ..Based on mathematical modeling, we discuss how these sequential loops control cell fate...
  79. pmc Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning
    Setsuko Sahara
    Molecular Neurobiology Laboratory, The Salk Institute, N Torrey Pines Road, La Jolla, CA 92037, USA
    Neural Dev 2:10. 2007
    ..relationships, we focused on Sp8, because it is transiently expressed in the CoP coincident with the expression of Fgf8, a morphogen implicated in area patterning of the neocortex...
  80. ncbi Differential requirements for FGF3, FGF8 and FGF10 during inner ear development
    Laura Cecilia Zelarayan
    Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Dev Biol 308:379-91. 2007
    ..In this study we have looked to define the redundant and conserved roles of FGF3, FGF8 and FGF10 during the development of the murine and avian inner ear...
  81. ncbi Two distinct sources for a population of maturing axial progenitors
    Noemi Cambray
    Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
    Development 134:2829-40. 2007
    ..Therefore, at least some aspects of progenitor status are conferred by the environment and are not an intrinsic property of the cells...
  82. ncbi A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation
    Alexander Aulehla
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Nat Cell Biol 10:186-93. 2008
    ..This gradient of nuclear beta-catenin defines the size of the oscillatory field and controls key aspects of PSM maturation and segment formation, emphasizing the central role of Wnt signalling in this process...
  83. doi FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development
    Toshiaki Okada
    Laboratory for Cell Culture Development, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Dev Biol 320:92-101. 2008
    b>FGF8 has been reported to act as a primary regulator of neocortical patterning along the anteroposterior (AP) axis in the mouse telencephalon, and disruption of FGF signaling causes distortion of molecular arealization along the AP axis...
  84. pmc Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons
    Wilson C J Chung
    Department of Integrative Physiology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    Endocrinology 149:4997-5003. 2008
    ..Mutations in both fibroblast growth factor receptor (Fgfr1) and Fgf8 have been shown to cause Kallmann syndrome, a disease characterized by hypogonadotropic hypogonadism and anosmia, ..
  85. ncbi Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function
    K M Wassarman
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco 94143 0452, USA
    Development 124:2923-34. 1997
    ..It is also required to maintain normal patterns of expression at the mid/hindbrain boundary of Fgf8 and Wnt1, genes that encode signaling molecules thought to be key components of the mid/hindbrain (isthmic) ..
  86. ncbi FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
    W Ye
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Cell 93:755-66. 1998
    ..We provide evidence that intersections of Shh, which is expressed along the ventral neural tube, and FGF8, which is locally produced at the mid/hindbrain boundary and in the rostral forebrain, create induction sites for ..
  87. ncbi p63 is a p53 homologue required for limb and epidermal morphogenesis
    A A Mills
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 398:708-13. 1999
    ..Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis...
  88. ncbi Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH
    E N Meyers
    Department of Anatomy and Program in Developmental Biology, School of Medicine, and Department of Pediatrics, School of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA
    Science 285:403-6. 1999
    A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant...
  89. ncbi Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures
    J Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 127:1833-43. 2000
    ..b>Fgf8 is thought to mediate this organizer function...
  90. ncbi Fgf8 signalling from the AER is essential for normal limb development
    M Lewandoski
    Department of Anatomy and Program in Developmental Biology, School of Medicine, San Francisco, California, USA
    Nat Genet 26:460-3. 2000
    ..Of the four mouse Fgf genes (Fgf4 , Fgf8, Fgf9, Fgf17) known to display AER-specific expression domains within the limb bud (AER-Fgfs), only Fgf8 is ..
  91. pmc The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
    M Yamamoto
    Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Japan
    Genes Dev 15:1242-56. 2001
    ..These results indicate that a Nodal-FoxH1 signaling pathway plays a central role in A-P patterning and node formation in the mouse...
  92. ncbi Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles
    Y Ohkubo
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, 401 Parnassus, P O Box 0984, San Francisco, CA 94143 0984, USA
    Neuroscience 111:1-17. 2002
    ..Implantation of BMP4 beads in the anterior neuropore of stage 10 chicken embryos repressed FGF8 and SHH expression...
  93. pmc The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development
    Raymond F Robledo
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Genes Dev 16:1089-101. 2002
    ..Furthermore, spatiotemporal-specific transgenic overexpression of Dlx5, in the apical ectodermal ridge of Dlx5/6 null mice can fully rescue Dlx/Dll function in limb outgrowth...
  94. ncbi Functions of FGF signalling from the apical ectodermal ridge in limb development
    Xin Sun
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, 94143 0452, USA
    Nature 418:501-8. 2002
    ..role of fibroblast growth factor (FGF) signalling from the apical ectodermal ridge (AER), we inactivated Fgf4 and Fgf8 in AER cells or their precursors at different stages of mouse limb development...
  95. pmc Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors
    Silvia Maretto
    Histology and Embryology Section, Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, 35131 Padua, Italy
    Proc Natl Acad Sci U S A 100:3299-304. 2003
    ..In summary, BAT-gal mice unveil the entire complexity of Wntbeta-catenin signaling in mammals and have broad application potentials for the identification of Wnt-responsive cell populations in development and disease...
  96. pmc Cell fate decisions within the mouse organizer are governed by graded Nodal signals
    Stephane D Vincent
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 17:1646-62. 2003
    ..These findings conclusively demonstrate that graded Nodal/Smad2 signals govern allocation of the axial mesendoderm precursors that selectively give rise to the ADE and PCP mesoderm...
  97. ncbi Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse
    Christopher B Brown
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 267:190-202. 2004
    ..We test the hypothesis that fibroblast growth factor 8 (Fgf8) functions downstream of Tbx1 by performing tissue-specific inactivation of Fgf8 using Tbx1-Cre ..
  98. ncbi Regulation of Otx2 expression and its functions in mouse forebrain and midbrain
    Daisuke Kurokawa
    Laboratory for Vertebrate Body Plan, Center for Developmental Biology CDB RIKEN Kobe, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0046, Japan
    Development 131:3319-31. 2004
    ..At E10.5 Otx1-/-Otx2DeltaFM/DeltaFM mutants, in which Otx2 expression under the FM2 enhancer remained, exhibited almost complete loss of the entire diencephalon and mesencephalon; the telencephalon did, however, develop...
  99. ncbi Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors
    Yoshihiko Satoh
    Center for Animal Resources and Development, Graduate School of Molecular and Genomic Pharmacy, Kumamoto University, 860 0811 Kumamoto, Japan
    Anat Embryol (Berl) 208:479-86. 2004
    ..To address the role of FGF during external genitalia development, we have analyzed the expression of FGF genes (Fgf8, 9, 10) and receptor genes (Fgfr1, r2IIIb, r2IIIc) in GT of mice...
  100. ncbi Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development
    Jennifer Selever
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, TX 77030, USA
    Dev Biol 276:268-79. 2004
    ..Moreover, the AER persisted longer in the Bmp4 mutant limb buds exposing the forming digits to prolonged Fgf8 signaling...
  101. pmc FGF8 initiates inner ear induction in chick and mouse
    Raj K Ladher
    Sensory Development, RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Genes Dev 19:603-13. 2005
    ..We show that endoderm is necessary for otic induction in the chick and that Fgf8, expressed in the chick endoderm subjacent to Fgf19, is both sufficient and necessary for the expression of Fgf19 ..

Research Grants12

  1. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
    ....
  2. Conditional gene trapping
    SUZANNE MANSOUR; Fiscal Year: 2004
    ..Successful completion of these aims will set the stage for large-scale gene trap cell line production, which will, in turn, accelerate the production of mouse models of human genetic disease. ..
  3. Body Plan Formation in Early Mouse Embryo
    Yusuke Marikawa; Fiscal Year: 2004
    ....
  4. Role of Gbx2 and Otx2 in the mes-met organizer function
    James Li; Fiscal Year: 2003
    ..abstract_text> ..
  5. The Ciona savignyi Genetic Map
    Arend Sidow; Fiscal Year: 2008
    ..Insights into the molecular mechanisms of regulation and development using Ciona as a model are highly effective and relevant to the homologous processes in human. ..
  6. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009
    ....
  7. Mutagenesis of Tbx3: a model of ulnar-mammary syndrome
    Anne M Moon; Fiscal Year: 2010
    ..The flexible model system we propose will be a valuable tool for developmental studies of many organs and lead to a deeper understanding of the genetic and molecular bases of congenital anomalies in humans. ..
  8. REGIONAL DIFFERENTIATION DURING FOREBRAIN DEVELOPMENT
    Anthony S LaMantia; Fiscal Year: 2010
    ....
  9. CONDITIONAL MUTAGENESIS OF FIBROBLAST GROWTH FACTORS
    Anne Moon; Fiscal Year: 2002
    ..The goal of the proposed project is to determine the roles of FGF4 and FGF8 during early limb development...
  10. GENETIC ANALYSIS OF EARLY LIMB DEVELOPMENT
    Arend Sidow; Fiscal Year: 2004
    ..Because Dac is likely to be the mouse ortholog of the human Split Hand/Foot Malformation 3 gene, this project may also bear direct relevance to understanding and diagnosis of congenital limb diseases. ..
  11. Zic3 and the Control of Body Pattern Formation
    STEPHANIE WARE; Fiscal Year: 2005
    ..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..
  12. The ProPhylER Database and Web Resource
    Arend Sidow; Fiscal Year: 2006
    ..unreadable] [unreadable]..