Genomes and Genes
Gene Symbol: Fgf8
Description: fibroblast growth factor 8
Alias: Aigf, Fgf-8, fibroblast growth factor 8, HBGF-8, androgen-induced growth factor, heparin-binding growth factor 8
Publications202 found, 100 shown here
- Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene functionC Chiang
Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
Nature 383:407-13. 1996..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
- Neocortex patterning by the secreted signaling molecule FGF8T Fukuchi-Shimogori
Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA
Science 294:1071-4. 2001..Here we provide evidence that FGF8 regulates development of the map from a source in the anterior telencephalon...
- Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signalingKatherine Shim
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, California 94143, USA
Dev Cell 8:553-64. 2005..Both this cell fate change and hearing loss can be partially rescued by reducing Fgf8 gene dosage in Spry2 null mutant mice...
- The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellumCandace L Chi
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
Development 130:2633-44. 2003..b>FGF8 and WNT1 have been implicated as key components of IsO signaling activity, and previous studies have shown that in ..
- Genetic evidence that FGFs have an instructive role in limb proximal-distal patterningFrancesca V Mariani
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California 94158 2324, USA
Nature 453:401-5. 2008..Fibroblast growth factor (FGF) gene family members are key AER-derived signals, with Fgf4, Fgf8, Fgf9 and Fgf17 expressed specifically in the mouse AER...
- Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limbYing Liu
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Development 129:5289-300. 2002Proximal-to-distal growth of the embryonic limbs requires Fgf10 in the mesenchyme to activate Fgf8 in the apical ectodermal ridge (AER), which in turn promotes mesenchymal outgrowth...
- Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in miceYasuhiko Kawakami
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
Development 138:4465-73. 2011..Our data demonstrate that Islet1 and β-catenin regulate outgrowth and Fgf10-Fgf8 feedback loop formation during vertebrate hindlimb initiation...
- A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryoT P Yamaguchi
Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
Development 126:1211-23. 1999..The reduced number of proliferating cells in both the progress zone and the primitive streak mesoderm suggests that one function of Wnt5a is to regulate the proliferation of progenitor cells...
- Isl1Cre reveals a common Bmp pathway in heart and limb developmentLei Yang
Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Development 133:1575-85. 2006..Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome. We provide evidence that the Tbx3 promoter is directly regulated by Bmp Smads in vivo...
- Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb budKazushi Aoto
Molecular Neuropathology Group, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Dev Biol 251:320-32. 2002..We observed an up-regulation of Fgf8 in the anterior neural ridge, isthmus, eye, facial primordia, and limb buds of mutant embryos, sites coinciding ..
- New semidominant mutations that affect mouse developmentDebora Bogani
Laboratory of Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX111 0RD, UK
Genesis 40:109-117. 2004..In one coat spotting mutant the homozygous condition is lethal before neural crest cell production commences. The mutated genes often function in processes additional to those alluded to by the heterozygous phenotype...
- Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochleaBonnie E Jacques
Section on Developmental Neuroscience, Porter Neuroscience Research Center, 35 Convent Dr, Room 2A 100, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Development 134:3021-9. 2007..Here, using in vitro and in vivo techniques, we demonstrate that an Fgf8 signal arising from the inner hair cells is the key component in an inductive pathway that regulates the number, ..
- Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulationNicholas Warr
Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, UK
Hum Mol Genet 17:2986-96. 2008..The analysis provides genetic evidence that Zic2 functions during organizer formation and that the PCP develops via a multi-step process...
- Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract developmentChen Wang
Department of Urology, Children s Hospital Boston, 300 Longwood Avenue, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 360:186-94. 2011..Thus, Six1 and Eya1 are key regulators of both upper and lower urinary tract morphogenesis. Results from this study uncover essential roles of the PCM progenitors during genitourinary tract formation...
- An obligatory role of mind bomb-1 in notch signaling of mammalian developmentBon Kyoung Koo
Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea
PLoS ONE 2:e1221. 2007..However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood...
- Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain regionMarkus Panhuysen
Institute of Developmental Genetics, GSF Research Center for Environment and Health, 85764 Neuherberg, Germany
Mol Cell Neurosci 26:101-11. 2004..We suggest that Wnt1 acts as a regulator of proliferation of specific precursor populations in the developing mid-/hindbrain region and is only secondarily involved in maintenance of the mid-/hindbrain organizer...
- Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud developmentX Sun
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California, USA
Nat Genet 25:83-6. 2000..We also found that maintenance of Fgf9 and Fgf17 expression is dependent on Shh, whereas Fgf8 expression is not...
- Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain regionWei Lin
Medical Research Council, National Institute for Medical Research, London, UK
Genesis 41:110-5. 2005..Altogether, our results demonstrate that Sef and Sproutys function synergistically to regulate Gbx2 expression in the anterior hindbrain...
- The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closureJinzhe Mao
Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
Development 137:3079-88. 2010..Finally, we demonstrate that this loss of forebrain maintenance is due in part to the iron deficiency that results from the absence of fully functional Fpn1...
- The canonical Wnt/β-catenin signaling pathway regulates Fgf signaling for early facial developmentYongping Wang
Department of Cell Biology and Human Anatomy, University of California, Davis, Sacramento, CA 95817, USA
Dev Biol 349:250-60. 2011..Gene expression of several cell-survival and patterning factors, including Fgf8, Fgf3, and Fgf17, is dramatically diminished in the anterior neural ridge (ANR, a rostral signaling center) and/or ..
- Ectodermal Wnt/β-catenin signaling shapes the mouse faceBethany S Reid
Department of Craniofacial Biology and Cell and Developmental Biology, University of Colorado Denver, 12801 East 17th Avenue, PO Box 6511, Aurora, CO 80045, USA
Dev Biol 349:261-9. 2011..There are accompanying alterations in the expression of Fgf8 and Shh, key molecules that establish a signaling center critical for facial patterning, the frontonasal ectodermal ..
- The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal archNeil T Sheehy
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Development 137:4307-16. 2010..expression in Dicer mutant pharyngeal arches, and regulated non-cell-autonomous signaling involving Wnt5a, Shh and Fgf8 that converged on Dlx2 regulation in PA1...
- Nuclear translocation of FGF8 and its implication to induce Sprouty2Ayumu Suzuki
Department of Molecular Neurobiology, Graduate School of Life Sciences and Institute of Development, Aging and Cancer, Tohoku University, Seiryo machi 4 1, Aoba ku, 980 8575 Sendai, Japan
Dev Growth Differ 54:463-73. 2012b>Fibroblast growth factor 8 (FGF8) functions as a local organizing signal for the tectum and cerebellum. FGF8 activates Ras-ERK signaling pathway to induce cerebellar development...
- The mouse Engrailed-1 gene and ventral limb patterningC A Loomis
Ronald O Perelman Deparment of Dermatology, New York University Medical School 10016, USA
Nature 382:360-3. 1996..Engrailed-1 seems to act in part by repressing dorsal differentiation induced by Wnt-7a, and is essential for proper formation of the apical ectodermal ridge...
- Genetic control of brain morphogenesis through Otx gene dosage requirementD Acampora
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Development 124:3639-50. 1997....
- Fgf-8 determines rostral-caudal polarity in the first branchial archA S Tucker
Department of Craniofacial Development, UMDS Guy s Hospital, London SE1 9RT, UK
Development 126:51-61. 1999....
- Fgf8 is required for outgrowth and patterning of the limbsA M Moon
Department of Pediatrics and Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
Nat Genet 26:455-9. 2000The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of ..
- Unique functions of Sonic hedgehog signaling during external genitalia developmentR Haraguchi
Center for Animal Resources and Development CARD and Graduate School of Molecular and Genomic Pharmacy, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
Development 128:4241-50. 2001..These results suggest a dual mode of Shh function, first by the regulation of initiating GT outgrowth, and second, by subsequent GT differentiation...
- Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephalyWei Zhang
Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
Dev Cell 10:657-65. 2006..Specific Cdo domains required for its promyogenic effect are dispensable for its Shh signaling role, suggesting that Cdo has multiple, independent functions...
- Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4Kentaro Suzuki
Center for Animal Resources and Development, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Eur J Hum Genet 16:36-44. 2008..These results suggest that different genes associated with human SHFM could also be involved in the aetiogenesis of hypospadias pointing toward a common molecular origin of these congenital malformations...
- Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limbYvan Lallemand
CNRS URA, Institut Pasteur, Paris, France
Dev Biol 331:189-98. 2009....
- Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in miceVictoria Randall
Molecular Medicine Unit, Institute of Child Health, London, United Kingdom
J Clin Invest 119:3301-10. 2009..We could not rescue PAA morphogenesis by restoring neural crest Chd7 expression. Rather, biallelic expression of Chd7 and Tbx1 in the pharyngeal ectoderm was required for normal PAA development...
- Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesisKazushi Aoto
Molecular Neuropathology Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Dev Biol 327:106-20. 2009..These findings provide new insight into the mechanism underlying HPE pathoetiology during dynamic brain and craniofacial morphogenesis...
- Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthoodXiu Ping Wang
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Development 136:1939-49. 2009..In addition, we identify Fgf8, a known tooth initiation marker, as a direct target of Wnt/beta-catenin signaling...
- Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract developmentFrances A High
Department of Cell and Developmental Biology, Cardiovascular Institute, and Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA
J Clin Invest 119:1986-96. 2009..In mid-gestation, these mutants displayed decreased Fgf8 and Bmp4 expression. Notch inhibition within the second heart field affected the development of neighboring tissues...
- An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombinationE N Meyers
Department of Anatomy, University of California, San Francisco 94143 0452, USA
Nat Genet 18:136-41. 1998..The 'allelogenic' mouse line we produced carries a hypomorphic allele of Fgf8, which can be converted to a null allele by mating to cre transgenic animals...
- Defects in limb, craniofacial, and thymic development in Jagged2 mutant miceR Jiang
The Jackson Laboratory, Bar Harbor, Maine 04609 USA
Genes Dev 12:1046-57. 1998..ridge (AER) of the limb buds of the mutant homozygotes is hyperplastic, and we observe an expanded domain of Fgf8 expression in the AER...
- The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient miceE A Grove
Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, IL, USA
Development 125:2315-25. 1998....
- Shh dependent and independent maintenance of basal midbrainAriadna Perez-Balaguer
Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
Mech Dev 126:301-13. 2009..Based on our results and recently published data, we suggest the existence of a specific genetic pathway for the specification of the mesencephalic red nucleus. Foxa2 could be the candidate gene that might control this genetic pathway...
- Lrp6-mediated canonical Wnt signaling is required for lip formation and fusionLanying Song
Department of Cell Biology and Human Anatomy, University of California, Davis, CA 95616, USA
Development 136:3161-71. 2009..Thus, the Lrp6-mediated Wnt signaling pathway is required for lip development by orchestrating two distinctively different morphogenetic movements...
- The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryoP H Crossley
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco 94143 0452, USA
Development 121:439-51. 1995..In this report, we provide a detailed analysis of the mouse Fgf8 gene...
- Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head developmentM Grigoriou
Division of Developmental Neurobiology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 125:2063-74. 1998..Furthermore, expression studies and bead implantation experiments in vitro have provided strong evidence that Fgf8 is primarily responsible for the restricted expression of Lhx6 and Lhx7 in the oral aspect of the maxillary and ..
- Experimental analysis of the emergence of left-right asymmetry of the body axis in early postimplantation mouse embryosT E Tsang
Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
Cell Mol Biol (Noisy-le-grand) 45:493-503. 1999..in the early gastrula shows that there is a transient asymmetric localization of the transcripts of Cerrl, Fgf8, Hesx1 and Hnf3beta gene in the anterior visceral endoderm, Otx2 and Sox2 in the epiblast and Lim1 in the nascent ..
- The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formationJ P Martinez Barbera
Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
Development 127:2433-45. 2000..All together, these results demonstrate that Hex function is essential in definitive endoderm for normal development of the forebrain, liver and thyroid gland...
- Fgfr1 regulates patterning of the pharyngeal regionNina Trokovic
Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
Genes Dev 17:141-53. 2003..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
- The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesisR Andrea DeYoung
Department of Molecular and Cell Biology, Division of Immunology, University of California at Berkeley, Berkeley, CA 94720 3200, USA
J Biol Chem 278:47104-9. 2003..Abnormal expression of a number of early developmental markers and defects in growth or distribution of emerging mesoderm cells were also detected. These data suggest that Nor-1 plays a crucial role in gastrulation...
- Fibroblast growth factor 8 induced downregulation of thrombospondin 1 is mediated by the MEK/ERK and PI3K pathways in breast cancer cellsKati Tarkkonen
Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, 20520, Turku, Finland
Growth Factors 28:256-67. 2010Expression of fibroblast growth factor 8 (FGF-8) is increased in several forms of hormonal cancer. It was previously shown to regulate expression of thrombospondin 1 (TSP-1), an inhibitor of angiogenesis, in S115 breast cancer cells...
- Msx1 and Msx2 in limb mesenchyme modulate digit number and identityVardina Bensoussan-Trigano
Institut Pasteur, Génétique Moléculaire de la Morphogenèse, CNRS URA 2578, Paris, France
Dev Dyn 240:1190-202. 2011..With this strategy, we demonstrate that mesenchymal expression of Msx1 and Msx2 is required for proper Shh and Bmp4 signaling to specify digit number and identity...
- α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in miceAmparo Girós
Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Burjassot, Spain
PLoS ONE 6:e22002. 2011..Thus, α5β1-mediated adhesion to FN in the PSM regulates the dynamics of membrane protrusions and cell-to-cell communication essential for elongation and segmentation of the body axis...
- Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressedG Minowada
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, CA 94143 0452, USA
Development 126:4465-75. 1999....
- Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null miceBart van De Sluis
Laboratory of Metabolic and Endocrine Diseases, Room KC 02 069 1, UMC Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
Mol Cell Biol 27:4142-56. 2007..Thus, this study identifies COMMD1 as a novel regulator of HIF-1 activity and shows that Commd1 deficiency in mice leads to embryonic lethality associated with dysregulated placenta vascularization...
- A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterningJean Denis Bénazet
Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Science 323:1050-3. 2009..This self-regulatory signaling network results in robust regulation of distal limb development that is able to compensate for variations by interconnectivity among the three signaling pathways...
- Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limbNatalie C Butterfield
The University of Queensland, Institute for Molecular Bioscience, Queensland, Australia
Development 136:3515-24. 2009..These results establish the importance of the downstream consequences of Hh pathway repression, and identify Ptc1 as a key player in limb patterning even prior to the onset of Shh expression...
- beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 regionDmitri Chilov
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
PLoS ONE 5:e10881. 2010..mouse midbrain-rhombomere 1 region leads to robust up-regulation of several Wnt signalling target genes, including Fgf8. Suggestive of direct transcriptional regulation of the Fgf8 gene, beta-catenin stabilization resulted in Fgf8 up-..
- Essential roles of fibronectin in the development of the left-right embryonic body planMaria V Pulina
Weill Cornell Medical College, Department of Medicine, Division of Cardiology, New York, NY, USA
Dev Biol 354:208-20. 2011..Taken together, our studies demonstrate the requisite role for a structural ECM protein and its integrin receptor in the development of the left-right axis of asymmetry in vertebrates...
- Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8W Ye
Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
Nat Neurosci 4:1175-81. 2001Local expression of FGF8 at the mid/hindbrain boundary (MHB) governs the development of multiple neurons and support cells...
- Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutantsJ A Cygan
Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
Development 124:5021-32. 1997..Unlike the normal AER, ectopic AER formation is dependent upon Wnt-7a activity, indicating that distinct genetic mechanisms may be involved in primary and secondary AER formation...
- Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbsC A Loomis
Ronald O Perelman Department of Dermatology, NYU Medical School, New York, NY 10016, USA
Development 125:1137-48. 1998..This leads to induction of a second zone of compaction ventrally, which in some cases goes on to form an autonomous secondary AER...
- Teeth. Where and how to make themH Peters
GSF Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany
Trends Genet 15:59-65. 1999..This cascade provides a molecular model by which reciprocal tissue interactions are controlled...
- Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial archA Trumpp
G W Hooper Foundation, Department of Microbiology, School of Medicine, University of California at San Francisco UCSF, San Francisco, California 94143 0552, USA
Genes Dev 13:3136-48. 1999..Here we used Cre/loxP technology to inactivate the mouse Fgf8 gene in this ectoderm and have obtained genetic evidence that FGF8 has a dual function in BA1: it promotes ..
- Nodal signalling in the epiblast patterns the early mouse embryoJ Brennan
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nature 411:965-9. 2001..Our experiments show that proximal-distal and subsequent anterior-posterior polarity of the pregastrulation embryo result from reciprocal cell-cell interactions between the epiblast and the two extra-embryonic tissues...
- Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog functionC Chiang
Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
Dev Biol 236:421-35. 2001..the architecture of the Shh(-/-) AER is gradually disrupted over developmental time in parallel with a reduction of Fgf8 expression in the ridge...
- Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTRP P Boyl
MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, New Hunt s House, London SE1 1UL, UK
Development 128:2989-3000. 2001..This leads us to hypothesise that this control might have important evolutionary implications...
- OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translationD Acampora
MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, New Hunts House, London SE1 9RT, UK
Development 128:4801-13. 2001..These data provide novel in vivo evidence supporting the concept that during evolution pre-existing gene functions have been recruited into new developmental pathways by modifying their regulatory control...
- Otx2 is required to respond to signals from anterior neural ridge for forebrain specificationE Tian
Department of Morphogenesis, Kumamoto University, Honjo 2 2 1, Kumamoto, 860 0811, Japan
Dev Biol 242:204-23. 2002..These results further suggest that Otx2 dosage may be crucial in the neural plate with respect to response to inductive signals primarily from the ANR for forebrain specification...
- FGFR1 is required for the development of the auditory sensory epitheliumUlla Pirvola
Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
Neuron 35:671-80. 2002..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium...
- Extraembryonic proteases regulate Nodal signalling during gastrulationSéverine Beck
Developmental Biology Group, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nat Cell Biol 4:981-5. 2002..A lack of Spc1 and Spc4 affects both pathways because these proteases also stimulate induction of Bmp4...
- Wnt3a plays a major role in the segmentation clock controlling somitogenesisAlexander Aulehla
Abteilung Entwicklungsbiologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108, Freiburg, Germany
Dev Cell 4:395-406. 2003..We propose that the segmentation clock is established by Wnt/beta-catenin signaling via a negative-feedback mechanism and that Wnt3a controls the segmentation process in vertebrates...
- Emx2 patterns the neocortex by regulating FGF positional signalingTomomi Fukuchi-Shimogori
Department of Neurobiology, Pharmacology and Physiology, University of Chicago, 947 East 58th Street, MC0926, Chicago, Illinois 60637, USA
Nat Neurosci 6:825-31. 2003Molecular genetic studies implicate fibroblast growth factor 8 (FGF8), and the transcription factor Emx2, in development of the neocortical area map...
- Sp8 is crucial for limb outgrowth and neuropore closureSheila M Bell
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 100:12195-200. 2003..These observations indicate that Sp8 functions downstream of Wnt3, Fgf10, and Bmpr1a in the signaling cascade that mediates AER formation...
- Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouseAlexandra A Blak
GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany
Dev Dyn 233:1023-30. 2005b>Fibroblast growth factor 8 (FGF8) mediates the function of the midbrain-hindbrain organizer (MHO). FGF signals are transmitted by means of four known FGF receptors (FGFRs)...
- The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner earJohanna Mantela
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Development 132:2377-88. 2005..Our findings demonstrate that the pRb pathway is required for hair cell quiescence and that manipulation of the cell cycle machinery disrupts the coordinated development within the inner ear sensory epithelia...
- Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery developmentZhen Zhang
Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
Development 132:5307-15. 2005..We also thereby demonstrate conclusively that the role of Tbx1 in fourth PAA development is cell non-autonomous...
- Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrumShubha Tole
Department of Biological Sciences, Room B304, Tata Institute of Fundamental Research, Colaba, Mumbai, India
Dev Biol 289:141-51. 2006....
- Regulation of osteoblast differentiation: a novel function for fibroblast growth factor 8Maija P Valta
Institute of Biomedicine, Department of Anatomy, University of Turku, Finland
Endocrinology 147:2171-82. 2006..The results suggest that FGF-8, which is expressed by a great proportion of malignant breast and prostate tumors, may, among other factors, also be involved in the formation of osteosclerotic bone metastases...
- LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1Alexandra Capela
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
Dev Biol 291:300-13. 2006..These regions also express high levels of the growth factors FGF8 and/or Wnt-1. We show here that LeX-containing molecules in the developing nervous system bind Wnt-1...
- Dose-dependent functions of Fgf8 in regulating telencephalic patterning centersElaine E Storm
Department of Anatomy, University of California, San Francisco, CA 94143 2711, USA
Development 133:1831-44. 2006Mouse embryos bearing hypomorphic and conditional null Fgf8 mutations have small and abnormally patterned telencephalons...
- The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4Nadav Ben-Haim
Ecole Polytechnique Fédérale de Lausanne EPFL ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Dev Cell 11:313-23. 2006..Based on mathematical modeling, we discuss how these sequential loops control cell fate...
- Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterningSetsuko Sahara
Molecular Neurobiology Laboratory, The Salk Institute, N Torrey Pines Road, La Jolla, CA 92037, USA
Neural Dev 2:10. 2007..relationships, we focused on Sp8, because it is transiently expressed in the CoP coincident with the expression of Fgf8, a morphogen implicated in area patterning of the neocortex...
- Differential requirements for FGF3, FGF8 and FGF10 during inner ear developmentLaura Cecilia Zelarayan
Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
Dev Biol 308:379-91. 2007..In this study we have looked to define the redundant and conserved roles of FGF3, FGF8 and FGF10 during the development of the murine and avian inner ear...
- Two distinct sources for a population of maturing axial progenitorsNoemi Cambray
Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
Development 134:2829-40. 2007..Therefore, at least some aspects of progenitor status are conferred by the environment and are not an intrinsic property of the cells...
- A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentationAlexander Aulehla
Stowers Institute for Medical Research, Kansas City, MO 64110, USA
Nat Cell Biol 10:186-93. 2008..This gradient of nuclear beta-catenin defines the size of the oscillatory field and controls key aspects of PSM maturation and segment formation, emphasizing the central role of Wnt signalling in this process...
- FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline developmentToshiaki Okada
Laboratory for Cell Culture Development, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
Dev Biol 320:92-101. 2008b>FGF8 has been reported to act as a primary regulator of neocortical patterning along the anteroposterior (AP) axis in the mouse telencephalon, and disruption of FGF signaling causes distortion of molecular arealization along the AP axis...
- Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neuronsWilson C J Chung
Department of Integrative Physiology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
Endocrinology 149:4997-5003. 2008..Mutations in both fibroblast growth factor receptor (Fgfr1) and Fgf8 have been shown to cause Kallmann syndrome, a disease characterized by hypogonadotropic hypogonadism and anosmia, ..
- Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene functionK M Wassarman
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco 94143 0452, USA
Development 124:2923-34. 1997..It is also required to maintain normal patterns of expression at the mid/hindbrain boundary of Fgf8 and Wnt1, genes that encode signaling molecules thought to be key components of the mid/hindbrain (isthmic) ..
- FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plateW Ye
Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
Cell 93:755-66. 1998..We provide evidence that intersections of Shh, which is expressed along the ventral neural tube, and FGF8, which is locally produced at the mid/hindbrain boundary and in the rostral forebrain, create induction sites for ..
- p63 is a p53 homologue required for limb and epidermal morphogenesisA A Mills
Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 398:708-13. 1999..Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis...
- Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHHE N Meyers
Department of Anatomy and Program in Developmental Biology, School of Medicine, and Department of Pediatrics, School of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA
Science 285:403-6. 1999A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant...
- Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structuresJ Xu
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
Development 127:1833-43. 2000..b>Fgf8 is thought to mediate this organizer function...
- Fgf8 signalling from the AER is essential for normal limb developmentM Lewandoski
Department of Anatomy and Program in Developmental Biology, School of Medicine, San Francisco, California, USA
Nat Genet 26:460-3. 2000..Of the four mouse Fgf genes (Fgf4 , Fgf8, Fgf9, Fgf17) known to display AER-specific expression domains within the limb bud (AER-Fgfs), only Fgf8 is ..
- The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouseM Yamamoto
Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Japan
Genes Dev 15:1242-56. 2001..These results indicate that a Nodal-FoxH1 signaling pathway plays a central role in A-P patterning and node formation in the mouse...
- Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesiclesY Ohkubo
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, 401 Parnassus, P O Box 0984, San Francisco, CA 94143 0984, USA
Neuroscience 111:1-17. 2002..Implantation of BMP4 beads in the anterior neuropore of stage 10 chicken embryos repressed FGF8 and SHH expression...
- The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal developmentRaymond F Robledo
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Genes Dev 16:1089-101. 2002..Furthermore, spatiotemporal-specific transgenic overexpression of Dlx5, in the apical ectodermal ridge of Dlx5/6 null mice can fully rescue Dlx/Dll function in limb outgrowth...
- Functions of FGF signalling from the apical ectodermal ridge in limb developmentXin Sun
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, 94143 0452, USA
Nature 418:501-8. 2002..role of fibroblast growth factor (FGF) signalling from the apical ectodermal ridge (AER), we inactivated Fgf4 and Fgf8 in AER cells or their precursors at different stages of mouse limb development...
- Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumorsSilvia Maretto
Histology and Embryology Section, Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, 35131 Padua, Italy
Proc Natl Acad Sci U S A 100:3299-304. 2003..In summary, BAT-gal mice unveil the entire complexity of Wntbeta-catenin signaling in mammals and have broad application potentials for the identification of Wnt-responsive cell populations in development and disease...
- Cell fate decisions within the mouse organizer are governed by graded Nodal signalsStephane D Vincent
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genes Dev 17:1646-62. 2003..These findings conclusively demonstrate that graded Nodal/Smad2 signals govern allocation of the axial mesendoderm precursors that selectively give rise to the ADE and PCP mesoderm...
- Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouseChristopher B Brown
Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Biol 267:190-202. 2004..We test the hypothesis that fibroblast growth factor 8 (Fgf8) functions downstream of Tbx1 by performing tissue-specific inactivation of Fgf8 using Tbx1-Cre ..
- Regulation of Otx2 expression and its functions in mouse forebrain and midbrainDaisuke Kurokawa
Laboratory for Vertebrate Body Plan, Center for Developmental Biology CDB RIKEN Kobe, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0046, Japan
Development 131:3319-31. 2004..At E10.5 Otx1-/-Otx2DeltaFM/DeltaFM mutants, in which Otx2 expression under the FM2 enhancer remained, exhibited almost complete loss of the entire diencephalon and mesencephalon; the telencephalon did, however, develop...
- Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptorsYoshihiko Satoh
Center for Animal Resources and Development, Graduate School of Molecular and Genomic Pharmacy, Kumamoto University, 860 0811 Kumamoto, Japan
Anat Embryol (Berl) 208:479-86. 2004..To address the role of FGF during external genitalia development, we have analyzed the expression of FGF genes (Fgf8, 9, 10) and receptor genes (Fgfr1, r2IIIb, r2IIIc) in GT of mice...
- Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER developmentJennifer Selever
Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, TX 77030, USA
Dev Biol 276:268-79. 2004..Moreover, the AER persisted longer in the Bmp4 mutant limb buds exposing the forming digits to prolonged Fgf8 signaling...
- FGF8 initiates inner ear induction in chick and mouseRaj K Ladher
Sensory Development, RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
Genes Dev 19:603-13. 2005..We show that endoderm is necessary for otic induction in the chick and that Fgf8, expressed in the chick endoderm subjacent to Fgf19, is both sufficient and necessary for the expression of Fgf19 ..
- Eda/Edar Regulation of Embryonic SMG DevelopmentTina Jaskoll; Fiscal Year: 2007....
- Conditional gene trappingSUZANNE MANSOUR; Fiscal Year: 2004..Successful completion of these aims will set the stage for large-scale gene trap cell line production, which will, in turn, accelerate the production of mouse models of human genetic disease. ..
- Body Plan Formation in Early Mouse EmbryoYusuke Marikawa; Fiscal Year: 2004....
- Role of Gbx2 and Otx2 in the mes-met organizer functionJames Li; Fiscal Year: 2003..abstract_text> ..
- The Ciona savignyi Genetic MapArend Sidow; Fiscal Year: 2008..Insights into the molecular mechanisms of regulation and development using Ciona as a model are highly effective and relevant to the homologous processes in human. ..
- PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINSRashmi Bansal; Fiscal Year: 2009....
- Mutagenesis of Tbx3: a model of ulnar-mammary syndromeAnne M Moon; Fiscal Year: 2010..The flexible model system we propose will be a valuable tool for developmental studies of many organs and lead to a deeper understanding of the genetic and molecular bases of congenital anomalies in humans. ..
- REGIONAL DIFFERENTIATION DURING FOREBRAIN DEVELOPMENTAnthony S LaMantia; Fiscal Year: 2010....
- CONDITIONAL MUTAGENESIS OF FIBROBLAST GROWTH FACTORSAnne Moon; Fiscal Year: 2002..The goal of the proposed project is to determine the roles of FGF4 and FGF8 during early limb development...
- GENETIC ANALYSIS OF EARLY LIMB DEVELOPMENTArend Sidow; Fiscal Year: 2004..Because Dac is likely to be the mouse ortholog of the human Split Hand/Foot Malformation 3 gene, this project may also bear direct relevance to understanding and diagnosis of congenital limb diseases. ..
- Zic3 and the Control of Body Pattern FormationSTEPHANIE WARE; Fiscal Year: 2005..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..
- The ProPhylER Database and Web ResourceArend Sidow; Fiscal Year: 2006..unreadable] [unreadable]..