Fgf3

Summary

Gene Symbol: Fgf3
Description: fibroblast growth factor 3
Alias: Fgf-3, Int-2, Int-P, fibroblast growth factor 3, HBGF-3, INT-2 proto-oncogene protein, heparin-binding growth factor 3, proto-oncogene Int-2
Species: mouse

Top Publications

  1. ncbi Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development
    S Vainio
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Cell 75:45-58. 1993
  2. ncbi FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis
    U Pirvola
    Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 20:6125-34. 2000
  3. ncbi Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis
    P Kettunen
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 219:322-32. 2000
  4. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
  5. ncbi FGF10 maintains stem cell compartment in developing mouse incisors
    Hidemitsu Harada
    Second Department of Oral Anatomy and Cell Biology, Kyushu Dental College, 2 6 1, Manazuru, Kokurakita ku, Kitakyushu, 803 8580, Japan
    Development 129:1533-41. 2002
  6. pmc Specification of the mammalian cochlea is dependent on Sonic hedgehog
    Martin M Riccomagno
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 16:2365-78. 2002
  7. ncbi Requirements for FGF3 and FGF10 during inner ear formation
    Yolanda Alvarez
    Center for Molecular Neurobiology Hamburg, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Development 130:6329-38. 2003
  8. ncbi Suppression of neural fate and control of inner ear morphogenesis by Tbx1
    Steven Raft
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 131:1801-12. 2004
  9. ncbi Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations
    Jelena S Arnold
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 133:977-87. 2006
  10. pmc Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling
    Elina Järvinen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P O Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 103:18627-32. 2006

Research Grants

  1. Investigating the Role of Tbx1 in Ear Development
    Evan Braunstein; Fiscal Year: 2008

Scientific Experts

  • Johanna R Rochester
  • M P Hoffman
  • Karine Rizzoti
  • J Lewis
  • Pin Xian Xu
  • James O Pickles
  • J Pispa
  • Ulla Pirvola
  • Evan M Braunstein
  • Akira Murakami
  • Francisco Barrionuevo
  • TINA F JASKOLL
  • R Maas
  • D W Morris
  • Raj K Ladher
  • Thomas Schimmang
  • Suzanne L Mansour
  • Victor Vendrell
  • Ophir D Klein
  • Thomas Theil
  • Lisa D Urness
  • Citlali Vázquez-Echeverría
  • Elena Dominguez-Frutos
  • Abigail Jackson
  • Laura Cecilia Zelarayan
  • Hinako M Takase
  • Yi Hui Chen
  • Sung Ho Huh
  • Yolanda Alvarez
  • Tadashi Okubo
  • Hu Zhao
  • M Albert Basson
  • Cristina Pujades
  • Binglai Chen
  • Masahiro Asada
  • Jianquan Chen
  • Cyril Charles
  • Shinichi Miyagawa
  • Shigeaki Kato
  • Steven S Chua
  • Chathurani S Jayasena
  • David M Ornitz
  • Makoto M Taketo
  • C Dickson
  • Renata Peterkova
  • Gail R Martin
  • Miroslav Peterka
  • Gen Yamada
  • Jelena S Arnold
  • Elina Järvinen
  • Raymond F Robledo
  • Jukka Jernvall
  • Dan Zou
  • Zhengshi Lin
  • Bernice E Morrow
  • Marianne Antoine
  • Alexandra A Blak
  • Maria Teresa Alonso
  • Jun Liao
  • Mark Maconochie
  • Sonja Nowotschin
  • Alda Vidrich
  • Norio Amizuka
  • Hidenori Ozaki
  • Steven Raft
  • Juha Partanen
  • Doris K Wu
  • Nina Trokovic
  • Tracy J Wright
  • Francesco J DeMayo
  • Bernice Morrow
  • Hidemitsu Harada
  • Sophia Y Tsai
  • Zhi Qing Ma
  • Nobuyuki Itoh
  • Sahrunizam Kasah
  • Elly S W Ngan
  • Martin M Riccomagno
  • Mohammad K Hajihosseini
  • Arnaud André Mailleux
  • Klaus Kratochwil
  • Tohru Itoh
  • Iris López-Hernández
  • Shizuo Akira
  • Atsushi Miyajima
  • Beatriz Durán Alonso
  • Yasuhiro Takikawa
  • Seitaro Ino
  • Chaoying Li
  • Salvador Martinez

Detail Information

Publications110 found, 100 shown here

  1. ncbi Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development
    S Vainio
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Cell 75:45-58. 1993
    ..In addition, BMP-4 induced its own mesenchymal expression. These findings support the hypothesis that BMP-4 mediates epithelial-mesenchymal interactions during early tooth development...
  2. ncbi FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis
    U Pirvola
    Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 20:6125-34. 2000
    ..Expression of FGF10 mRNA partly overlapped with FGF3 mRNA in the sensory regions, suggesting that they may form parallel signaling pathways within the otic epithelium...
  3. ncbi Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis
    P Kettunen
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 219:322-32. 2000
    ..The dynamic expression patterns of different Fgfs in dental epithelium and mesenchyme and their interactions suggest existence of regulatory signaling cascades between epithelial and mesenchymal FGFs during tooth development...
  4. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
    ..Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor...
  5. ncbi FGF10 maintains stem cell compartment in developing mouse incisors
    Hidemitsu Harada
    Second Department of Oral Anatomy and Cell Biology, Kyushu Dental College, 2 6 1, Manazuru, Kokurakita ku, Kitakyushu, 803 8580, Japan
    Development 129:1533-41. 2002
    ..We found that the absence of the cervical loop was due to a divergence in Fgf10 and Fgf3 expression patterns at E16...
  6. pmc Specification of the mammalian cochlea is dependent on Sonic hedgehog
    Martin M Riccomagno
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 16:2365-78. 2002
    ..Taken together, our data support a model whereby auditory cell fates in the otic vesicle are established by the direct action of Shh...
  7. ncbi Requirements for FGF3 and FGF10 during inner ear formation
    Yolanda Alvarez
    Center for Molecular Neurobiology Hamburg, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Development 130:6329-38. 2003
    ..b>FGF3 is expressed in the developing hindbrain and has been shown to be involved in inner ear development of different ..
  8. ncbi Suppression of neural fate and control of inner ear morphogenesis by Tbx1
    Steven Raft
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 131:1801-12. 2004
    ..We propose that Tbx1 acts in the manner of a selector gene to control neural and sensory organ fate specification in the otocyst...
  9. ncbi Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations
    Jelena S Arnold
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 133:977-87. 2006
    ..These results show that Tbx1 in the PE is required for the patterning and development of the pharyngeal apparatus, thereby disrupting the formation of its derivative structures...
  10. pmc Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling
    Elina Järvinen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P O Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 103:18627-32. 2006
    ..These results may implicate Wnt signaling in tooth renewal, a capacity that was all but lost when mammals evolved progressively more complicated tooth shapes...
  11. pmc An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors
    Ophir D Klein
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
    Development 135:377-85. 2008
    ..These data reveal that the generation of differentiated progeny from a particular stem cell population can be differently regulated in the embryo and adult...
  12. pmc Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development
    Jianquan Chen
    Department of Biology, University of Rochester, Rochester, New York 14642, USA
    Dev Biol 334:174-85. 2009
    ..We show that mesenchymal beta-catenin function is required for expression of Lef1 and Fgf3 in the developing tooth mesenchyme and for induction of primary enamel knot in the developing tooth epithelium...
  13. pmc Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program
    Shinichi Miyagawa
    Institute of Molecular Embryology and Genetics, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 860 0811, Japan
    Development 136:3969-78. 2009
    ..Our results provide new insights into the integration of growth factor signaling in the appendicular developmental programs that regulate external genitalia development...
  14. pmc FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice
    Klaus Kratochwil
    Institute of Molecular Biology, Austrian Academy of Sciences, 5020 Salzburg, Austria
    Genes Dev 16:3173-85. 2002
    ..In addition, we find that FGF4 beads induce rapidly the expression of Fgf3 in dental mesenchyme and that both epithelial and mesenchymal FGF proteins induce the delayed expression of Shh in ..
  15. pmc Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling
    Ophir D Klein
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Dev Cell 11:181-90. 2006
    ....
  16. ncbi Chromosomal localizations of mouse Fgf2 and Fgf5 genes
    M G Mattei
    U 242 INSERM, Hopital d Enfants de la Timone, Marseille, France
    Mamm Genome 2:135-7. 1992
  17. ncbi New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regions
    V Ollendorff
    Laboratory of Molecular Oncology, U 119 INSERM, Marseille, France
    Mamm Genome 2:195-200. 1992
    ..The human and mouse genes belong to a conserved group of synteny. This, together with the similar conservation of the FGF and TYR genes, indicates that the human 11q13-q14 and mouse 7E-7F regions share homology...
  18. ncbi The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in human and to the distal region of mouse chromosome 7
    M A Pritchard
    Department of Cytogenetics and Molecular Genetics, Adelaide Children s Hospital, Australia
    Genomics 10:801-6. 1991
    ..Interestingly, the position on human chromosome 16 suggests that the IL4R may be a candidate for rearrangements, as 12;16 translocations are often associated with myxoid liposarcomas...
  19. ncbi Expression of the fibroblast growth factor-5 gene in the mouse embryo
    O Haub
    Columbia University College of Physicians and Surgeons, Department of Biochemistry and Molecular Biophysics, New York, NY 10032
    Development 112:397-406. 1991
    ..At several of these sites, expression is spatially restricted within the tissues. We offer several hypotheses regarding the roles of FGF-5 in murine development...
  20. ncbi Subcellular fate of the int-2 oncoprotein is determined by choice of initiation codon
    P Acland
    Imperial Cancer Research Fund Laboratories, UK
    Nature 343:662-5. 1990
    ..These data indicate that the Int-2 oncoprotein could influence cellular behaviour by two distinct mechanisms...
  21. pmc Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors
    R Smith
    Imperial Cancer Research Fund Laboratories, London, UK
    EMBO J 7:1013-22. 1988
    ....
  22. pmc Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus
    R Moore
    EMBO J 5:919-24. 1986
    ..These results are discussed in relation to the status of int-2 as a candidate proto-oncogene...
  23. ncbi Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
    S L Mansour
    Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City 84112
    Nature 336:348-52. 1988
    ..The procedure was applied to the isolation of hprt- and int-2- mutants, but it should be applicable to any gene...
  24. ncbi Activation of cellular gene by mouse mammary tumour virus may occur early in mammary tumour development
    G Peters
    Nature 309:273-5. 1984
    ..These data suggest that either the expression of the int-2 locus or the function of this putative oncogene must remain responsive to hormones and that some additional event must be responsible for the transition to autonomous growth...
  25. ncbi The cDNA sequence of mouse uroporphyrinogen III synthase and assignment to mouse chromosome 7
    M Bensidhoum
    Departement de Biochimie Medicale et Biologie Moleculaire, Universite de Bordeaux II, France
    Mamm Genome 5:728-30. 1994
  26. ncbi Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr)
    M A Frohman
    Department of Anatomy, School of Medicine, University of California, San Francisco 94143
    Development 117:925-36. 1993
    ....
  27. ncbi Localization of the mouse gene (Bc1) encoding neural BC1 RNA near the fibroblast growth factor 3 locus (Fgf3) on distal chromosome 7
    B A Taylor
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 44:153-4. 1997
  28. ncbi FGF signaling in mouse gastrulation and anteroposterior patterning
    J Rossant
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cold Spring Harb Symp Quant Biol 62:127-33. 1997
  29. ncbi Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia
    P X Xu
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 23:113-7. 1999
    ..In addition, our results suggest that an evolutionarily conserved Pax-Eya-Six regulatory hierarchy is used in mammalian ear and kidney development...
  30. ncbi Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb
    J M Revest
    Imperial Cancer Research Fund, London, UK
    J Immunol 167:1954-61. 2001
    ..Nevertheless, sufficient epithelial cell differentiation occurs in the severely hypoplastic thymus to allow the development of CD4/CD8-double-positive thymocytes and a very small number of single-positive thymocytes expressing TCRs...
  31. ncbi Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest
    A Gavalas
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 128:3017-27. 2001
    ..Furthermore, they demonstrate that early patterning of the separate components of the pharyngeal arches can proceed independently of neural crest cell migration...
  32. pmc Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid
    Pin Xian Xu
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Development 129:3033-44. 2002
    ..5 in Eya1(-/-) embryos. Our results indicate that Eya1 controls critical early inductive events involved in the morphogenesis of thymus, parathyroid and thyroid...
  33. pmc Inducible expression of FGF-3 in mouse mammary gland
    Elly S W Ngan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:11187-92. 2002
    ..Taken together, the mifepristone-inducible regulatory system provides a powerful means for understanding the diverse roles of FGF-3 and its interactions with hormones in mammary gland tumorigenesis...
  34. ncbi Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
    Zhengshi Lin
    Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
    Development 132:2309-18. 2005
    ..However, Gbx2 promotes ventral fates such as the saccule and cochlear duct, possibly by restricting Otx2 expression...
  35. ncbi Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse
    Alexandra A Blak
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany
    Dev Dyn 233:1023-30. 2005
    ..Fgfr3 expression is in contact with the Fgf8 expression domain only in the rostroventral hindbrain. Based on these findings, we postulate a role for FGFR2 and FGFR3 in FGF signaling in the ventral midbrain and hindbrain...
  36. ncbi Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2
    Marianne Antoine
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen, Germany
    Biochem Biophys Res Commun 338:1248-55. 2005
    The secreted isoform of fibroblast growth factor 3 (FGF3) induces a mitogenic cell response, while the nuclear form inhibits cell proliferation...
  37. ncbi Differential requirements for FGF3, FGF8 and FGF10 during inner ear development
    Laura Cecilia Zelarayan
    Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Dev Biol 308:379-91. 2007
    ..In this study we have looked to define the redundant and conserved roles of FGF3, FGF8 and FGF10 during the development of the murine and avian inner ear...
  38. doi Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain
    Citlali Vázquez-Echeverría
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, C Dr Aiguader 88, 08003 Barcelona, Spain
    Dev Biol 322:167-78. 2008
    ..Although many reports have pointed to the role of FGF3 in otic regionalisation, we provide evidence that FGF3 is not sufficient to govern this process...
  39. doi Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4
    Binglai Chen
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of NYU, New York, NY 10029, USA
    Dev Biol 326:75-85. 2009
    ....
  40. pmc Alk5-mediated transforming growth factor β signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells
    Hu Zhao
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Mol Cell Biol 31:2079-89. 2011
    ..The number of BrdU label-retaining cells (LRCs) was dramatically reduced in Alk5 mutant mice. Fgf10, Fgf3, and Fgf9 signals in the dental mesenchyme were downregulated in Wnt1-Cre; Alk5(fl/fl) incisors...
  41. pmc Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal
    Sung Ho Huh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 10:e1001231. 2012
    ..The viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans...
  42. pmc FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration
    Hinako M Takase
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Genes Dev 27:169-81. 2013
    ..These findings provide new insights into the cellular and molecular basis for LPC regulation and identify FGF7 as a potential therapeutic target for liver diseases...
  43. pmc Genetic rescue of Muenke syndrome model hearing loss reveals prolonged FGF-dependent plasticity in cochlear supporting cell fates
    Suzanne L Mansour
    Department of Human Genetics
    Genes Dev 27:2320-31. 2013
    ..This property might be exploited for the regulation of sensory cell regeneration from support cells...
  44. pmc Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis
    Abigail Jackson
    Department of Craniofacial Development and Stem Cell Biology, King s College, London, United Kingdom
    Dev Dyn 243:1143-51. 2014
    ..In particular, the question as to how Tbx1 expression in the pharyngeal endoderm regulates pharyngeal pouch morphogenesis in the mouse embryo is not known...
  45. doi Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos
    Yi Hui Chen
    Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan
    Dev Dyn 241:1651-64. 2012
    ..Hence we are interested in studying the molecular mechanisms underlying lineage defects of parthenotes...
  46. doi Roles of Wnt8a during formation and patterning of the mouse inner ear
    Victor Vendrell
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003 Valladolid, Spain
    Mech Dev 130:160-8. 2013
    ..Whereas several Fgfs including Fgf3, Fgf8 and Fgf10 have been shown to participate during early placode induction, Wnt signalling is required for ..
  47. ncbi Int-2, an autocrine and/or ultra-short-range effector in transgenic mammary tissue transplants
    D M Ornitz
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Mass
    J Natl Cancer Inst 84:887-92. 1992
    ..The Int-2 protein (fibroblast growth factor 3) is a member of the heparin-binding growth factor family of proteins...
  48. ncbi Localization of 11q13 loci with respect to regional chromosomal breakpoints
    P Szepetowski
    LGMCH, CNRS URA 1462, Nice, France
    Genomics 12:738-44. 1992
    ....
  49. ncbi Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse
    L Niswander
    Department of Anatomy, School of Medicine, University of California, San Francisco 94143
    Development 114:755-68. 1992
    ..Taken together, the data suggest that individual members of the gene family are expressed sequentially in developmental pathways such as mesoderm formation and myogenesis, and play a role in specific epithelial-mesenchymal interactions...
  50. pmc Insertion mutation of the int-1 and int-2 loci by mouse mammary tumor virus in premalignant and malignant neoplasms from the GR mouse strain
    D W Morris
    Department of Pathology, School of Medicine, University of California, Davis 95616
    J Virol 64:1794-802. 1990
    ..Insertion mutation of int-1 and int-2 is therefore not stage specific in this system...
  51. pmc Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development
    A Jakobovits
    Proc Natl Acad Sci U S A 83:7806-10. 1986
    ..Thus, these two proto-oncogenes, activated during mammary carcinogenesis by the same mechanisms, are normally expressed at different times and places in embryonic and adult mice...
  52. pmc A preferred region for integration of Friend murine leukemia virus in hematopoietic neoplasms is closely linked to the Int-2 oncogene
    J Silver
    J Virol 60:1156-8. 1986
    ..Studies at the RNA and DNA level prove that these loci are distinct...
  53. ncbi Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7
    D E Barton
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Genomics 3:17-24. 1988
    ..Comparison of the genetic maps of human chromosome 11 and mouse chromosome 7 leads to hypotheses regarding the evolution of human chromosome 11...
  54. pmc Four classes of mRNA are expressed from the mouse int-2 gene, a member of the FGF gene family
    S L Mansour
    Department of Anatomy, University of California, San Francisco 94143
    EMBO J 7:2035-41. 1988
    ..All four mRNAs share a common core sequence that encodes a protein with amino acid similarity to fibroblast growth factor...
  55. ncbi Survey of int region DNA rearrangements in C3H and BALB/cfC3H mouse mammary tumor system
    V K Pathak
    J Natl Cancer Inst 78:327-31. 1987
    ..However, the int-1 rearrangement maintained in 1 BALB/cfC3H HPO line through 11 transplant generations suggests that the int-1 rearrangement is neither sufficient nor necessary for progression to mouse mammary carcinoma...
  56. pmc Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes
    G Peters
    Mol Cell Biol 4:375-8. 1984
    ..This constitutes proof that int-1 and int-2 are discrete genetic loci. It is therefore possible that proviral activation of two distinct cellular genes may result in the same neoplastic disease...
  57. pmc Mouse gastric mucin: cloning and chromosomal localization
    L L Shekels
    Department of Medicine, University of Minnesota, Minneapolis 55417, USA
    Biochem J 311:775-85. 1995
    ..Due to sequence similarity and predominant expression in the stomach, the MGM gene may be considered a MUC5AC homologue and named Muc5ac...
  58. ncbi Clonal variations among multiple primary mammary tumors and within a tumor of individual mice: insertion mutations of int oncogenes
    N H Sarkar
    Department of Medicine, Medical College of Georgia, Augusta 30912 2400, USA
    Virology 212:490-9. 1995
    ....
  59. ncbi The role of Hoxa-3 in mouse thymus and thyroid development
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Development 121:1989-2003. 1995
    ..This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3...
  60. ncbi Multiple roles for FGF-3 during cranial neural development in the chicken
    R Mahmood
    MRC Brain Development Programme, UMDS Guy s Hospital, London, UK
    Development 121:1399-410. 1995
    ..Expression was also detected in the segmental plate and in the posterior half of the three most-recently generated somites...
  61. pmc Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice
    F S Lee
    Department of Genetics, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 92:2268-72. 1995
    ..This newly discovered Wnt family member was expressed in the embryo and mammary gland of virgin but not pregnant mice and represents a candidate collaborating oncogene of int-2/Fgf-3 in the mammary epithelium...
  62. ncbi Expression and function of FGF-4 in peri-implantation development in mouse embryos
    D A Rappolee
    Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143 0750
    Development 120:2259-69. 1994
    ..These findings indicate that FGF-4 produced by undifferentiated ICM cells acts in the peri-implantation period of embryogenesis to influence the production and behavior of endoderm cells derived from them...
  63. ncbi Targeted disruption of int-2 (fgf-3) causes developmental defects in the tail and inner ear
    S L Mansour
    Department of Human Genetics Eccles Institute of Genetics, University of Utah, Salt Lake City
    Mol Reprod Dev 39:62-7; discussion 67-8. 1994
    ..In addition to the tail phenotype, the surviving homozygotes show, to varying extents, symptoms characteristic of inner ear abnormalities.(ABSTRACT TRUNCATED AT 250 WORDS)..
  64. ncbi fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation
    T P Yamaguchi
    Samuel Lunenfeld Research Institute SLRI, Mount Sinai Hospital, Toronto, Ontario, Canada
    Genes Dev 8:3032-44. 1994
    ..These results suggest that FGFR-1 transduces signals that specify mesodermal cell fates and regional patterning of the mesoderm during gastrulation...
  65. ncbi Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes
    J Santos
    Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, NY 10016
    Cytogenet Cell Genet 62:217-9. 1993
    ..m. poschiavinus, and M. spretus. Polymorphic DNA fragments for the 18 DNA probes have been identified using Southern blot hybridization and restriction fragment length polymorphism (RFLP) analysis...
  66. ncbi Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
    P J Swiatek
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 7:2071-84. 1993
    ..These data demonstrate that Krox20 plays an essential role during development of the hindbrain and associated cranial sensory ganglia in mice...
  67. ncbi Two rhombomeres are altered in Hoxa-1 mutant mice
    M Mark
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Development 119:319-38. 1993
    ..This phenotype is compared with that of the Hoxa-1-/- mutants generated by O. Chisaka, T. S. Musci and M. R. Capecchi, 1992 (Nature 335, 516-520) and with that of the mice homozygous for the kreisler mutation...
  68. ncbi Activation of both Wnt-1 and Fgf-3 by insertion of mouse mammary tumor virus downstream in the reverse orientation: a reappraisal of the enhancer insertion model
    N Clausse
    Imperial Cancer Research Fund Laboratories, London, United Kingdom
    Virology 194:157-65. 1993
    ..These structural alterations can be reconciled with the enhancer insertion model by postulating that the viral enhancer can only function if it is not transcribed...
  69. ncbi Genetic mapping of three GABAA receptor-subunit genes in the mouse
    M Danciger
    Jules Stein Eye Institute, UCLA School of Medicine
    Genomics 16:361-5. 1993
    ..The Gabrb-1, Gabra-2 pair of genes on Chr 5 maps near the mouse "circling mutation" pi (pirouette)...
  70. ncbi Overexpression of cyclin D1 in mouse skin carcinogenesis
    A B Bianchi
    Department of Carcinogenesis, University of Texas, M D Anderson Cancer Center, Smithville 78957
    Oncogene 8:1127-33. 1993
    ..Further studies on the role of cyclin D1 in the mouse model system should prove valuable for understanding the multistep basis of tumor progression...
  71. ncbi Reassignment of the H-ras-1 gene to the Hbb-terminus region of mouse chromosome 7
    A B Bianchi
    University of Texas, M D Anderson Cancer Center, Smithville 78957
    Mamm Genome 4:220-2. 1993
  72. ncbi Expression of Fgf-3 in relation to hindbrain segmentation, otic pit position and pharyngeal arch morphology in normal and retinoic acid-exposed mouse embryos
    R Mahmood
    MRC Brain Development Programme, Division of Anatomy and Cell Biology, UMDS Guy s Hospital, London, UK
    Anat Embryol (Berl) 194:13-22. 1996
    ....
  73. ncbi The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26
    A Elson
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 31:373-5. 1996
    ..Both isoforms have been suggested to arise from a single gene through the use of alternative promoters and 5' exons. The identification of a single PTP epsilon locus in both organisms is consistent with this suggestion...
  74. ncbi Identification of a MMTV insertion mutation within the coding region of the Fgf-3 protooncogene
    D W Morris
    Department of Medical Pathology, University of California, Davis 95616, USA
    Virology 238:161-5. 1997
    ..These data document the first exception to the generalization that the Fgf-3 coding region is not disrupted by MMTV insertion mutation...
  75. ncbi A quantitative method for evaluation of FGF family and FGF receptor family gene expression by RT-PCR
    K Ozawa
    Cell Biology Laboratory, National Institute of Bioscience and Human Technology, Ibaraki, Japan
    Brain Res Brain Res Protoc 1:211-6. 1997
    ....
  76. ncbi Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3/Fgf4 locus
    M B Carlton
    Wellcome Trust, Cancer Research Campaign, Institute of Cancer, University of Cambridge, United Kingdom
    Dev Dyn 212:242-9. 1998
    ..The retroviral vector integration responsible for the Bey mutation is inserted in the intragenic region between Fgf3 and Fgf4...
  77. ncbi Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic mice
    M L Robinson
    Children s Hospital Research Foundation, Columbus, Ohio 43205, USA
    Dev Biol 198:13-31. 1998
    ..Expression of FGF-3 in the lens also resulted in developmental alterations of the eyelids, cornea, and retina, and in the most severely affected transgenic lines, the postnatal appearance of intraocular glandular structures...
  78. ncbi FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development
    M Bei
    Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Development 125:4325-33. 1998
    ..epithelial and mesenchymal Fgfs in wild-type and Msx1 mutant tooth germs and tested the ability of FGFs to induce Fgf3 and Bmp4 expression in wild-type and Msx1 mutant dental mesenchymal explants...
  79. ncbi Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
    K Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, Illkirch, C U de Strasbourg, France
    Nat Genet 21:444-8. 1999
    ..Our data establish that RA synthesized by the post-implantation mammalian embryo is an essential developmental hormone whose lack leads to early embryo death...
  80. ncbi HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo
    A Perea-Gomez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP163, CU de Strasbourg, France
    Development 126:4499-511. 1999
    ..Moreover, HNF3beta (-)(/)(-);Lim1(-)(/)(-) mutant embryos also exhibit defects in mesoderm patterning that are likely due to lack of specification of anterior primitive streak cells...
  81. ncbi Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
    J Pispa
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Biol 216:521-34. 1999
    ..Instead FGF-10 partially restored morphogenesis and stimulated the development of additional tooth cusps in cultured Tabby molars...
  82. ncbi Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ
    X Zhao
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Mech Dev 99:29-38. 2000
    ..driven by the mouse Msx1promoter in the dental mesenchyme restored the expression of Lef-1 and Dlx2 but neither Fgf3 nor syndecan-1 in the Msx1 mutant molar tooth germ...
  83. pmc Phenotypic consequences of lung-specific inducible expression of FGF-3
    B Zhao
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:5898-903. 2001
    ..Both phenotypes were reversible after the withdrawal of RU486. This system will be a valuable means of investigating the diverse roles of FGFs in the adult lung...
  84. ncbi Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation
    K D Tremblay
    Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 128:3609-21. 2001
    ..Collectively, these data have uncovered a unique function for Smad1 signaling in coordinating the growth of extra-embryonic structures necessary to support development within the uterine environment...
  85. ncbi Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 170:83-98. 2002
    ..Finally, our observations of abnormal SMGs in BMP7(-/-) and Pax6(-/-) indicate that both BMP7 and Pax6 play important roles during embryonic SMG branching morphogenesis...
  86. ncbi Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development
    Mohammad K Hajihosseini
    School of Biosciences, The University of Birmingham, B15 2TT, UK
    Mech Dev 113:79-83. 2002
    ....
  87. pmc Fgfr1 regulates patterning of the pharyngeal region
    Nina Trokovic
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Genes Dev 17:141-53. 2003
    ..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
  88. ncbi Fgf3 and Fgf10 are required for mouse otic placode induction
    Tracy J Wright
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
    Development 130:3379-90. 2003
    ..In mice, Fgf3 is expressed in the neurectoderm prior to and concomitant with placode induction and otic vesicle formation, but ..
  89. ncbi Six1 controls patterning of the mouse otic vesicle
    Hidenori Ozaki
    Division of Biology, Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    Development 131:551-62. 2004
    ..In the otic vesicle of Six1-deficient embryos, expressions of Otx1, Otx2, Lfng and Fgf3, which were expressed ventrally in the wild-type otic vesicles, were abolished, while the expression domains of ..
  90. ncbi Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development
    Norio Amizuka
    Department of Oral Biological Science, Graduate School for Medical and Dental Sciences, Niigata University Faculty of Dentistry, Niigata 951 8514, Japan
    Bone 34:13-25. 2004
    ....
  91. ncbi Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis
    Alda Vidrich
    Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia 22908, USA
    Dev Dyn 230:114-23. 2004
    ..These data suggest that signaling through FGFR-3 plays a role in regulating morphogenic events involved in formation of intestinal crypts and/or the fate of epithelial stem cells...
  92. pmc FGF8 initiates inner ear induction in chick and mouse
    Raj K Ladher
    Sensory Development, RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Genes Dev 19:603-13. 2005
    ..In chick, the mesodermal signal, FGF19, induces neural ectoderm to express additional signals, including WNT8c and FGF3, resulting in induction of the otic placode...
  93. ncbi Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, Maine
    Genesis 44:425-37. 2006
    ..Given their proximity to the disease locus and the observed phenotype in Dlx5/6 null mice, Dlx5/6 are likely candidates to mediate the inner ear defects observed in patients with split hand/split foot malformation...
  94. doi Sox9 is required for invagination of the otic placode in mice
    Francisco Barrionuevo
    Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Dev Biol 317:213-24. 2008
    ....
  95. pmc Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
    Chathurani S Jayasena
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 135:2251-61. 2008
    ....
  96. doi Glycosaminoglycan affinity of the complete fibroblast growth factor family
    Masahiro Asada
    Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8566, Japan
    Biochim Biophys Acta 1790:40-8. 2009
    ....
  97. doi Differential requirements for Fgf3 and Fgf8 during mouse forebrain development
    Thomas Theil
    Centres for Neuroscience Research and Integrative Physiology, University of Edinburgh, Edinburgh, Scotland
    Dev Dyn 237:3417-23. 2008
    ..Next to Fgf8, Fgf3 also influences telencephalic gene expression in the zebrafish...
  98. pmc Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition
    Cyril Charles
    Department of Orofacial Sciences, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0442, USA
    Proc Natl Acad Sci U S A 106:22364-8. 2009
    ..Here, we report that alterations in dosage of the Fgf3 gene cause morphological changes in both genetically engineered mutant mice and in human patients...
  99. pmc FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a
    Lisa D Urness
    Department of Human Genetics, University of Utah, 15 N 2030 E, RM 2100, Salt Lake City, UT 84112 5330, USA
    Dev Biol 340:595-604. 2010
    ..Mouse embryos lacking both Fgf3 and Fgf10 fail to initiate inner ear development because appropriate patterns of gene expression fail to be ..
  100. doi Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice
    Tadashi Okubo
    Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan
    Development 138:339-48. 2011
    ..Together, our results show that Ripply3 plays a role in pharyngeal development, probably by regulating Tbx1 activity...
  101. ncbi A novel polymorphism near the mouse Int-2 locus
    N M Navone
    University of Texas, M D Anderson Cancer Center, Science Park Research Division, Smithville 78957
    Mamm Genome 3:296-7. 1992

Research Grants1

  1. Investigating the Role of Tbx1 in Ear Development
    Evan Braunstein; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..