Genomes and Genes
Gene Symbol: Fgf3
Description: fibroblast growth factor 3
Alias: Fgf-3, Int-2, Int-P, fibroblast growth factor 3, HBGF-3, INT-2 proto-oncogene protein, heparin-binding growth factor 3, proto-oncogene Int-2
Publications110 found, 100 shown here
- Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth developmentS Vainio
Department of Pedodontics and Orthodontics, University of Helsinki, Finland
Cell 75:45-58. 1993..In addition, BMP-4 induced its own mesenchymal expression. These findings support the hypothesis that BMP-4 mediates epithelial-mesenchymal interactions during early tooth development...
- FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesisU Pirvola
Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 20:6125-34. 2000..Expression of FGF10 mRNA partly overlapped with FGF3 mRNA in the sensory regions, suggesting that they may form parallel signaling pathways within the otic epithelium...
- Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesisP Kettunen
Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
Dev Dyn 219:322-32. 2000..The dynamic expression patterns of different Fgfs in dental epithelium and mesenchyme and their interactions suggest existence of regulatory signaling cascades between epithelial and mesenchymal FGFs during tooth development...
- Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryoArnaud André Mailleux
UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
Development 129:53-60. 2002..Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor...
- FGF10 maintains stem cell compartment in developing mouse incisorsHidemitsu Harada
Second Department of Oral Anatomy and Cell Biology, Kyushu Dental College, 2 6 1, Manazuru, Kokurakita ku, Kitakyushu, 803 8580, Japan
Development 129:1533-41. 2002..We found that the absence of the cervical loop was due to a divergence in Fgf10 and Fgf3 expression patterns at E16...
- Specification of the mammalian cochlea is dependent on Sonic hedgehogMartin M Riccomagno
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genes Dev 16:2365-78. 2002..Taken together, our data support a model whereby auditory cell fates in the otic vesicle are established by the direct action of Shh...
- Requirements for FGF3 and FGF10 during inner ear formationYolanda Alvarez
Center for Molecular Neurobiology Hamburg, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
Development 130:6329-38. 2003..b>FGF3 is expressed in the developing hindbrain and has been shown to be involved in inner ear development of different ..
- Suppression of neural fate and control of inner ear morphogenesis by Tbx1Steven Raft
Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Development 131:1801-12. 2004..We propose that Tbx1 acts in the manner of a selector gene to control neural and sensory organ fate specification in the otocyst...
- Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformationsJelena S Arnold
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Development 133:977-87. 2006..These results show that Tbx1 in the PE is required for the patterning and development of the pharyngeal apparatus, thereby disrupting the formation of its derivative structures...
- Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signalingElina Järvinen
Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P O Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
Proc Natl Acad Sci U S A 103:18627-32. 2006..These results may implicate Wnt signaling in tooth renewal, a capacity that was all but lost when mammals evolved progressively more complicated tooth shapes...
- An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisorsOphir D Klein
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
Development 135:377-85. 2008..These data reveal that the generation of differentiated progeny from a particular stem cell population can be differently regulated in the embryo and adult...
- Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth developmentJianquan Chen
Department of Biology, University of Rochester, Rochester, New York 14642, USA
Dev Biol 334:174-85. 2009..We show that mesenchymal beta-catenin function is required for expression of Lef1 and Fgf3 in the developing tooth mesenchyme and for induction of primary enamel knot in the developing tooth epithelium...
- Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular programShinichi Miyagawa
Institute of Molecular Embryology and Genetics, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 860 0811, Japan
Development 136:3969-78. 2009..Our results provide new insights into the integration of growth factor signaling in the appendicular developmental programs that regulate external genitalia development...
- FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) miceKlaus Kratochwil
Institute of Molecular Biology, Austrian Academy of Sciences, 5020 Salzburg, Austria
Genes Dev 16:3173-85. 2002..In addition, we find that FGF4 beads induce rapidly the expression of Fgf3 in dental mesenchyme and that both epithelial and mesenchymal FGF proteins induce the delayed expression of Shh in ..
- Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signalingOphir D Klein
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
Dev Cell 11:181-90. 2006....
- Chromosomal localizations of mouse Fgf2 and Fgf5 genesM G Mattei
U 242 INSERM, Hopital d Enfants de la Timone, Marseille, France
Mamm Genome 2:135-7. 1992
- New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regionsV Ollendorff
Laboratory of Molecular Oncology, U 119 INSERM, Marseille, France
Mamm Genome 2:195-200. 1992..The human and mouse genes belong to a conserved group of synteny. This, together with the similar conservation of the FGF and TYR genes, indicates that the human 11q13-q14 and mouse 7E-7F regions share homology...
- The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in human and to the distal region of mouse chromosome 7M A Pritchard
Department of Cytogenetics and Molecular Genetics, Adelaide Children s Hospital, Australia
Genomics 10:801-6. 1991..Interestingly, the position on human chromosome 16 suggests that the IL4R may be a candidate for rearrangements, as 12;16 translocations are often associated with myxoid liposarcomas...
- Expression of the fibroblast growth factor-5 gene in the mouse embryoO Haub
Columbia University College of Physicians and Surgeons, Department of Biochemistry and Molecular Biophysics, New York, NY 10032
Development 112:397-406. 1991..At several of these sites, expression is spatially restricted within the tissues. We offer several hypotheses regarding the roles of FGF-5 in murine development...
- Subcellular fate of the int-2 oncoprotein is determined by choice of initiation codonP Acland
Imperial Cancer Research Fund Laboratories, UK
Nature 343:662-5. 1990..These data indicate that the Int-2 oncoprotein could influence cellular behaviour by two distinct mechanisms...
- Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factorsR Smith
Imperial Cancer Research Fund Laboratories, London, UK
EMBO J 7:1013-22. 1988....
- Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virusR Moore
EMBO J 5:919-24. 1986..These results are discussed in relation to the status of int-2 as a candidate proto-oncogene...
- Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genesS L Mansour
Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City 84112
Nature 336:348-52. 1988..The procedure was applied to the isolation of hprt- and int-2- mutants, but it should be applicable to any gene...
- Activation of cellular gene by mouse mammary tumour virus may occur early in mammary tumour developmentG Peters
Nature 309:273-5. 1984..These data suggest that either the expression of the int-2 locus or the function of this putative oncogene must remain responsive to hormones and that some additional event must be responsible for the transition to autonomous growth...
- The cDNA sequence of mouse uroporphyrinogen III synthase and assignment to mouse chromosome 7M Bensidhoum
Departement de Biochimie Medicale et Biologie Moleculaire, Universite de Bordeaux II, France
Mamm Genome 5:728-30. 1994
- Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr)M A Frohman
Department of Anatomy, School of Medicine, University of California, San Francisco 94143
Development 117:925-36. 1993....
- Localization of the mouse gene (Bc1) encoding neural BC1 RNA near the fibroblast growth factor 3 locus (Fgf3) on distal chromosome 7B A Taylor
Jackson Laboratory, Bar Harbor, Maine 04609, USA
Genomics 44:153-4. 1997
- FGF signaling in mouse gastrulation and anteroposterior patterningJ Rossant
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Cold Spring Harb Symp Quant Biol 62:127-33. 1997
- Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordiaP X Xu
Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 23:113-7. 1999..In addition, our results suggest that an evolutionarily conserved Pax-Eya-Six regulatory hierarchy is used in mammalian ear and kidney development...
- Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIbJ M Revest
Imperial Cancer Research Fund, London, UK
J Immunol 167:1954-61. 2001..Nevertheless, sufficient epithelial cell differentiation occurs in the severely hypoplastic thymus to allow the development of CD4/CD8-double-positive thymocytes and a very small number of single-positive thymocytes expressing TCRs...
- Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crestA Gavalas
Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 128:3017-27. 2001..Furthermore, they demonstrate that early patterning of the separate components of the pharyngeal arches can proceed independently of neural crest cell migration...
- Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroidPin Xian Xu
McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
Development 129:3033-44. 2002..5 in Eya1(-/-) embryos. Our results indicate that Eya1 controls critical early inductive events involved in the morphogenesis of thymus, parathyroid and thyroid...
- Inducible expression of FGF-3 in mouse mammary glandElly S W Ngan
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 99:11187-92. 2002..Taken together, the mifepristone-inducible regulatory system provides a powerful means for understanding the diverse roles of FGF-3 and its interactions with hormones in mammary gland tumorigenesis...
- Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signalingZhengshi Lin
Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
Development 132:2309-18. 2005..However, Gbx2 promotes ventral fates such as the saccule and cochlear duct, possibly by restricting Otx2 expression...
- Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouseAlexandra A Blak
GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany
Dev Dyn 233:1023-30. 2005..Fgfr3 expression is in contact with the Fgf8 expression domain only in the rostroventral hindbrain. Based on these findings, we postulate a role for FGFR2 and FGFR3 in FGF signaling in the ventral midbrain and hindbrain...
- Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2Marianne Antoine
Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen, Germany
Biochem Biophys Res Commun 338:1248-55. 2005The secreted isoform of fibroblast growth factor 3 (FGF3) induces a mitogenic cell response, while the nuclear form inhibits cell proliferation...
- Differential requirements for FGF3, FGF8 and FGF10 during inner ear developmentLaura Cecilia Zelarayan
Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
Dev Biol 308:379-91. 2007..In this study we have looked to define the redundant and conserved roles of FGF3, FGF8 and FGF10 during the development of the murine and avian inner ear...
- Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domainCitlali Vázquez-Echeverría
Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, C Dr Aiguader 88, 08003 Barcelona, Spain
Dev Biol 322:167-78. 2008..Although many reports have pointed to the role of FGF3 in otic regionalisation, we provide evidence that FGF3 is not sufficient to govern this process...
- Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4Binglai Chen
Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of NYU, New York, NY 10029, USA
Dev Biol 326:75-85. 2009....
- Alk5-mediated transforming growth factor β signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cellsHu Zhao
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
Mol Cell Biol 31:2079-89. 2011..The number of BrdU label-retaining cells (LRCs) was dramatically reduced in Alk5 mutant mice. Fgf10, Fgf3, and Fgf9 signals in the dental mesenchyme were downregulated in Wnt1-Cre; Alk5(fl/fl) incisors...
- Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signalSung Ho Huh
Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
PLoS Biol 10:e1001231. 2012..The viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans...
- FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regenerationHinako M Takase
Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
Genes Dev 27:169-81. 2013..These findings provide new insights into the cellular and molecular basis for LPC regulation and identify FGF7 as a potential therapeutic target for liver diseases...
- Genetic rescue of Muenke syndrome model hearing loss reveals prolonged FGF-dependent plasticity in cochlear supporting cell fatesSuzanne L Mansour
Department of Human Genetics
Genes Dev 27:2320-31. 2013..This property might be exploited for the regulation of sensory cell regeneration from support cells...
- Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesisAbigail Jackson
Department of Craniofacial Development and Stem Cell Biology, King s College, London, United Kingdom
Dev Dyn 243:1143-51. 2014..In particular, the question as to how Tbx1 expression in the pharyngeal endoderm regulates pharyngeal pouch morphogenesis in the mouse embryo is not known...
- Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryosYi Hui Chen
Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan
Dev Dyn 241:1651-64. 2012..Hence we are interested in studying the molecular mechanisms underlying lineage defects of parthenotes...
- Roles of Wnt8a during formation and patterning of the mouse inner earVictor Vendrell
Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003 Valladolid, Spain
Mech Dev 130:160-8. 2013..Whereas several Fgfs including Fgf3, Fgf8 and Fgf10 have been shown to participate during early placode induction, Wnt signalling is required for ..
- Int-2, an autocrine and/or ultra-short-range effector in transgenic mammary tissue transplantsD M Ornitz
Howard Hughes Medical Institute, Harvard Medical School, Boston, Mass
J Natl Cancer Inst 84:887-92. 1992..The Int-2 protein (fibroblast growth factor 3) is a member of the heparin-binding growth factor family of proteins...
- Localization of 11q13 loci with respect to regional chromosomal breakpointsP Szepetowski
LGMCH, CNRS URA 1462, Nice, France
Genomics 12:738-44. 1992....
- Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouseL Niswander
Department of Anatomy, School of Medicine, University of California, San Francisco 94143
Development 114:755-68. 1992..Taken together, the data suggest that individual members of the gene family are expressed sequentially in developmental pathways such as mesoderm formation and myogenesis, and play a role in specific epithelial-mesenchymal interactions...
- Insertion mutation of the int-1 and int-2 loci by mouse mammary tumor virus in premalignant and malignant neoplasms from the GR mouse strainD W Morris
Department of Pathology, School of Medicine, University of California, Davis 95616
J Virol 64:1794-802. 1990..Insertion mutation of int-1 and int-2 is therefore not stage specific in this system...
- Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse developmentA Jakobovits
Proc Natl Acad Sci U S A 83:7806-10. 1986..Thus, these two proto-oncogenes, activated during mammary carcinogenesis by the same mechanisms, are normally expressed at different times and places in embryonic and adult mice...
- A preferred region for integration of Friend murine leukemia virus in hematopoietic neoplasms is closely linked to the Int-2 oncogeneJ Silver
J Virol 60:1156-8. 1986..Studies at the RNA and DNA level prove that these loci are distinct...
- Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7D E Barton
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
Genomics 3:17-24. 1988..Comparison of the genetic maps of human chromosome 11 and mouse chromosome 7 leads to hypotheses regarding the evolution of human chromosome 11...
- Four classes of mRNA are expressed from the mouse int-2 gene, a member of the FGF gene familyS L Mansour
Department of Anatomy, University of California, San Francisco 94143
EMBO J 7:2035-41. 1988..All four mRNAs share a common core sequence that encodes a protein with amino acid similarity to fibroblast growth factor...
- Survey of int region DNA rearrangements in C3H and BALB/cfC3H mouse mammary tumor systemV K Pathak
J Natl Cancer Inst 78:327-31. 1987..However, the int-1 rearrangement maintained in 1 BALB/cfC3H HPO line through 11 transplant generations suggests that the int-1 rearrangement is neither sufficient nor necessary for progression to mouse mammary carcinoma...
- Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomesG Peters
Mol Cell Biol 4:375-8. 1984..This constitutes proof that int-1 and int-2 are discrete genetic loci. It is therefore possible that proviral activation of two distinct cellular genes may result in the same neoplastic disease...
- Mouse gastric mucin: cloning and chromosomal localizationL L Shekels
Department of Medicine, University of Minnesota, Minneapolis 55417, USA
Biochem J 311:775-85. 1995..Due to sequence similarity and predominant expression in the stomach, the MGM gene may be considered a MUC5AC homologue and named Muc5ac...
- Clonal variations among multiple primary mammary tumors and within a tumor of individual mice: insertion mutations of int oncogenesN H Sarkar
Department of Medicine, Medical College of Georgia, Augusta 30912 2400, USA
Virology 212:490-9. 1995....
- The role of Hoxa-3 in mouse thymus and thyroid developmentN R Manley
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
Development 121:1989-2003. 1995..This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3...
- Multiple roles for FGF-3 during cranial neural development in the chickenR Mahmood
MRC Brain Development Programme, UMDS Guy s Hospital, London, UK
Development 121:1399-410. 1995..Expression was also detected in the segmental plate and in the posterior half of the three most-recently generated somites...
- Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic miceF S Lee
Department of Genetics, Harvard Medical School, Boston, MA 02115
Proc Natl Acad Sci U S A 92:2268-72. 1995..This newly discovered Wnt family member was expressed in the embryo and mammary gland of virgin but not pregnant mice and represents a candidate collaborating oncogene of int-2/Fgf-3 in the mammary epithelium...
- Expression and function of FGF-4 in peri-implantation development in mouse embryosD A Rappolee
Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143 0750
Development 120:2259-69. 1994..These findings indicate that FGF-4 produced by undifferentiated ICM cells acts in the peri-implantation period of embryogenesis to influence the production and behavior of endoderm cells derived from them...
- Targeted disruption of int-2 (fgf-3) causes developmental defects in the tail and inner earS L Mansour
Department of Human Genetics Eccles Institute of Genetics, University of Utah, Salt Lake City
Mol Reprod Dev 39:62-7; discussion 67-8. 1994..In addition to the tail phenotype, the surviving homozygotes show, to varying extents, symptoms characteristic of inner ear abnormalities.(ABSTRACT TRUNCATED AT 250 WORDS)..
- fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulationT P Yamaguchi
Samuel Lunenfeld Research Institute SLRI, Mount Sinai Hospital, Toronto, Ontario, Canada
Genes Dev 8:3032-44. 1994..These results suggest that FGFR-1 transduces signals that specify mesodermal cell fates and regional patterning of the mesoderm during gastrulation...
- Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomesJ Santos
Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, NY 10016
Cytogenet Cell Genet 62:217-9. 1993..m. poschiavinus, and M. spretus. Polymorphic DNA fragments for the 18 DNA probes have been identified using Southern blot hybridization and restriction fragment length polymorphism (RFLP) analysis...
- Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20P J Swiatek
Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
Genes Dev 7:2071-84. 1993..These data demonstrate that Krox20 plays an essential role during development of the hindbrain and associated cranial sensory ganglia in mice...
- Two rhombomeres are altered in Hoxa-1 mutant miceM Mark
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
Development 119:319-38. 1993..This phenotype is compared with that of the Hoxa-1-/- mutants generated by O. Chisaka, T. S. Musci and M. R. Capecchi, 1992 (Nature 335, 516-520) and with that of the mice homozygous for the kreisler mutation...
- Activation of both Wnt-1 and Fgf-3 by insertion of mouse mammary tumor virus downstream in the reverse orientation: a reappraisal of the enhancer insertion modelN Clausse
Imperial Cancer Research Fund Laboratories, London, United Kingdom
Virology 194:157-65. 1993..These structural alterations can be reconciled with the enhancer insertion model by postulating that the viral enhancer can only function if it is not transcribed...
- Genetic mapping of three GABAA receptor-subunit genes in the mouseM Danciger
Jules Stein Eye Institute, UCLA School of Medicine
Genomics 16:361-5. 1993..The Gabrb-1, Gabra-2 pair of genes on Chr 5 maps near the mouse "circling mutation" pi (pirouette)...
- Overexpression of cyclin D1 in mouse skin carcinogenesisA B Bianchi
Department of Carcinogenesis, University of Texas, M D Anderson Cancer Center, Smithville 78957
Oncogene 8:1127-33. 1993..Further studies on the role of cyclin D1 in the mouse model system should prove valuable for understanding the multistep basis of tumor progression...
- Reassignment of the H-ras-1 gene to the Hbb-terminus region of mouse chromosome 7A B Bianchi
University of Texas, M D Anderson Cancer Center, Smithville 78957
Mamm Genome 4:220-2. 1993
- Expression of Fgf-3 in relation to hindbrain segmentation, otic pit position and pharyngeal arch morphology in normal and retinoic acid-exposed mouse embryosR Mahmood
MRC Brain Development Programme, Division of Anatomy and Cell Biology, UMDS Guy s Hospital, London, UK
Anat Embryol (Berl) 194:13-22. 1996....
- The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26A Elson
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genomics 31:373-5. 1996..Both isoforms have been suggested to arise from a single gene through the use of alternative promoters and 5' exons. The identification of a single PTP epsilon locus in both organisms is consistent with this suggestion...
- Identification of a MMTV insertion mutation within the coding region of the Fgf-3 protooncogeneD W Morris
Department of Medical Pathology, University of California, Davis 95616, USA
Virology 238:161-5. 1997..These data document the first exception to the generalization that the Fgf-3 coding region is not disrupted by MMTV insertion mutation...
- A quantitative method for evaluation of FGF family and FGF receptor family gene expression by RT-PCRK Ozawa
Cell Biology Laboratory, National Institute of Bioscience and Human Technology, Ibaraki, Japan
Brain Res Brain Res Protoc 1:211-6. 1997....
- Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3/Fgf4 locusM B Carlton
Wellcome Trust, Cancer Research Campaign, Institute of Cancer, University of Cambridge, United Kingdom
Dev Dyn 212:242-9. 1998..The retroviral vector integration responsible for the Bey mutation is inserted in the intragenic region between Fgf3 and Fgf4...
- Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic miceM L Robinson
Children s Hospital Research Foundation, Columbus, Ohio 43205, USA
Dev Biol 198:13-31. 1998..Expression of FGF-3 in the lens also resulted in developmental alterations of the eyelids, cornea, and retina, and in the most severely affected transgenic lines, the postnatal appearance of intraocular glandular structures...
- FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth developmentM Bei
Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Development 125:4325-33. 1998..epithelial and mesenchymal Fgfs in wild-type and Msx1 mutant tooth germs and tested the ability of FGFs to induce Fgf3 and Bmp4 expression in wild-type and Msx1 mutant dental mesenchymal explants...
- Embryonic retinoic acid synthesis is essential for early mouse post-implantation developmentK Niederreither
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, Illkirch, C U de Strasbourg, France
Nat Genet 21:444-8. 1999..Our data establish that RA synthesized by the post-implantation mammalian embryo is an essential developmental hormone whose lack leads to early embryo death...
- HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryoA Perea-Gomez
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP163, CU de Strasbourg, France
Development 126:4499-511. 1999..Moreover, HNF3beta (-)(/)(-);Lim1(-)(/)(-) mutant embryos also exhibit defects in mesoderm patterning that are likely due to lack of specification of anterior primitive streak cells...
- Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGFJ Pispa
Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
Dev Biol 216:521-34. 1999..Instead FGF-10 partially restored morphogenesis and stimulated the development of additional tooth cusps in cultured Tabby molars...
- Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germX Zhao
Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
Mech Dev 99:29-38. 2000..driven by the mouse Msx1promoter in the dental mesenchyme restored the expression of Lef-1 and Dlx2 but neither Fgf3 nor syndecan-1 in the Msx1 mutant molar tooth germ...
- Phenotypic consequences of lung-specific inducible expression of FGF-3B Zhao
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 98:5898-903. 2001..Both phenotypes were reversible after the withdrawal of RU486. This system will be a valuable means of investigating the diverse roles of FGFs in the adult lung...
- Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formationK D Tremblay
Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 128:3609-21. 2001..Collectively, these data have uncovered a unique function for Smad1 signaling in coordinating the growth of extra-embryonic structures necessary to support development within the uterine environment...
- Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) miceTina Jaskoll
Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
Cells Tissues Organs 170:83-98. 2002..Finally, our observations of abnormal SMGs in BMP7(-/-) and Pax6(-/-) indicate that both BMP7 and Pax6 play important roles during embryonic SMG branching morphogenesis...
- Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb developmentMohammad K Hajihosseini
School of Biosciences, The University of Birmingham, B15 2TT, UK
Mech Dev 113:79-83. 2002....
- Fgfr1 regulates patterning of the pharyngeal regionNina Trokovic
Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
Genes Dev 17:141-53. 2003..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
- Fgf3 and Fgf10 are required for mouse otic placode inductionTracy J Wright
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
Development 130:3379-90. 2003..In mice, Fgf3 is expressed in the neurectoderm prior to and concomitant with placode induction and otic vesicle formation, but ..
- Six1 controls patterning of the mouse otic vesicleHidenori Ozaki
Division of Biology, Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
Development 131:551-62. 2004..In the otic vesicle of Six1-deficient embryos, expressions of Otx1, Otx2, Lfng and Fgf3, which were expressed ventrally in the wild-type otic vesicles, were abolished, while the expression domains of ..
- Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone developmentNorio Amizuka
Department of Oral Biological Science, Graduate School for Medical and Dental Sciences, Niigata University Faculty of Dentistry, Niigata 951 8514, Japan
Bone 34:13-25. 2004....
- Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesisAlda Vidrich
Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia 22908, USA
Dev Dyn 230:114-23. 2004..These data suggest that signaling through FGFR-3 plays a role in regulating morphogenic events involved in formation of intestinal crypts and/or the fate of epithelial stem cells...
- FGF8 initiates inner ear induction in chick and mouseRaj K Ladher
Sensory Development, RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
Genes Dev 19:603-13. 2005..In chick, the mesodermal signal, FGF19, induces neural ectoderm to express additional signals, including WNT8c and FGF3, resulting in induction of the otic placode...
- Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatusRaymond F Robledo
The Jackson Laboratory, Bar Harbor, Maine
Genesis 44:425-37. 2006..Given their proximity to the disease locus and the observed phenotype in Dlx5/6 null mice, Dlx5/6 are likely candidates to mediate the inner ear defects observed in patients with split hand/split foot malformation...
- Sox9 is required for invagination of the otic placode in miceFrancisco Barrionuevo
Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
Dev Biol 317:213-24. 2008....
- Notch signaling augments the canonical Wnt pathway to specify the size of the otic placodeChathurani S Jayasena
Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
Development 135:2251-61. 2008....
- Glycosaminoglycan affinity of the complete fibroblast growth factor familyMasahiro Asada
Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8566, Japan
Biochim Biophys Acta 1790:40-8. 2009....
- Differential requirements for Fgf3 and Fgf8 during mouse forebrain developmentThomas Theil
Centres for Neuroscience Research and Integrative Physiology, University of Edinburgh, Edinburgh, Scotland
Dev Dyn 237:3417-23. 2008..Next to Fgf8, Fgf3 also influences telencephalic gene expression in the zebrafish...
- Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentitionCyril Charles
Department of Orofacial Sciences, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0442, USA
Proc Natl Acad Sci U S A 106:22364-8. 2009..Here, we report that alterations in dosage of the Fgf3 gene cause morphological changes in both genetically engineered mutant mice and in human patients...
- FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8aLisa D Urness
Department of Human Genetics, University of Utah, 15 N 2030 E, RM 2100, Salt Lake City, UT 84112 5330, USA
Dev Biol 340:595-604. 2010..Mouse embryos lacking both Fgf3 and Fgf10 fail to initiate inner ear development because appropriate patterns of gene expression fail to be ..
- Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in miceTadashi Okubo
Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan
Development 138:339-48. 2011..Together, our results show that Ripply3 plays a role in pharyngeal development, probably by regulating Tbx1 activity...
- A novel polymorphism near the mouse Int-2 locusN M Navone
University of Texas, M D Anderson Cancer Center, Science Park Research Division, Smithville 78957
Mamm Genome 3:296-7. 1992
- Investigating the Role of Tbx1 in Ear DevelopmentEvan Braunstein; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..