Fgf21

Summary

Gene Symbol: Fgf21
Description: fibroblast growth factor 21
Alias: fibroblast growth factor 21, FGF-21
Species: mouse

Top Publications

  1. pmc Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:3143-8. 2012
  2. pmc PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis
    Jennifer L Estall
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:22510-5. 2009
  3. pmc Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    Elayne Hondares
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
    Cell Metab 11:206-12. 2010
  4. pmc Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    Elayne Hondares
    Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, and CIBER Fisiopatologia de la Obesidad y Nutricion, 08028 Barcelona, Catalonia, Spain
    J Biol Chem 286:12983-90. 2011
  5. ncbi FGF10 and FGF21 as regulators in adipocyte development and metabolism
    Hiroya Ohta
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Endocr Metab Immune Disord Drug Targets 11:302-9. 2011
  6. pmc Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
    Ffolliott M Fisher
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Endocrinology 152:2996-3004. 2011
  7. doi Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice
    Katsutaka Oishi
    Biological Clock Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 412:396-400. 2011
  8. pmc Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes
    Wei Chen
    Department of Geriatrics, Hua Shan Hospital, Fudan University, Shanghai 200040, China
    J Biol Chem 286:34559-66. 2011
  9. doi Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet
    Takashi Uebanso
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    J Nutr Biochem 23:785-90. 2012
  10. doi Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance
    Clarence Hale
    Department of Metabolic Disorders, Amgen Inc, MS 29 1 A, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Endocrinology 153:69-80. 2012

Scientific Experts

  • Elayne Hondares
  • Katsutaka Oishi
  • Ana Planavila
  • Kenneth R Feingold
  • Yu Li
  • Hiroshi Kurosu
  • Alexei Kharitonenkov
  • Radmila Micanovic
  • Morichika Konishi
  • Nobuyuki Itoh
  • Steven A Kliewer
  • David J Mangelsdorf
  • Andrew C Adams
  • Shufang Wu
  • Eleftheria Maratos-Flier
  • Wei Wei
  • Chaofeng Yang
  • Takeshi Inagaki
  • Ffolliott M Fisher
  • Xinle Wu
  • Jeffrey S Flier
  • Moosa Mohammadi
  • Regina Goetz
  • Seong Hun Kim
  • Xunde Wang
  • Michael K Badman
  • Kook Hwan Kim
  • Yihong Wan
  • Xiaokun Li
  • Francesco De Luca
  • Paul A Dutchak
  • Aimin Xu
  • Bruce M Spiegelman
  • Eric D Berglund
  • Matthew J Potthoff
  • Jennifer L Estall
  • Holly A Bina
  • Xunshan Ding
  • Masahiro Asada
  • Masashi Suzuki
  • Yun Hee Youm
  • Yanli Cheng
  • Wen Du
  • Thomas Laeger
  • Yusuke Joki
  • Katsunori Nonogaki
  • Ricardo J Samms
  • Julia M Assini
  • Yori Ozaki
  • Lili Tian
  • Lu Cai
  • Yi Tan
  • Wenke Feng
  • Chi Zhang
  • P J Antonellis
  • A Špolcová
  • Sung Hoon Back
  • Xingguo Cheng
  • Hyoung Kyu Kim
  • Myung Shik Lee
  • Shan Jiang
  • Christine Cheng
  • Christine C Cheng
  • Zhuofeng Lin
  • Xin Tong
  • Kirk M Habegger
  • Xin Jiang
  • Fen Wang
  • Yongde Luo
  • Wallace L McKeehan
  • Mark Y Sun
  • Hua Liu
  • Ling Li
  • Bin Sun
  • Amena Archer
  • Gangyi Yang
  • Takeshi Katafuchi
  • Yuan Zhang
  • Mengliu Yang
  • Guenther Boden
  • Holly A Cyphert
  • Svetlana M Altamentova
  • Eunjong Yoo
  • Aaron Y K Ming
  • Jonathan V Rocheleau
  • Clarence Hale
  • Takashi Uebanso
  • Ke Li
  • Dawn M Kilkenny
  • Jie Yu

Detail Information

Publications81

  1. pmc Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:3143-8. 2012
    The endocrine hormone fibroblast growth factor 21 (FGF21) is a powerful modulator of glucose and lipid metabolism and a promising drug for type 2 diabetes. Here we identify FGF21 as a potent regulator of skeletal homeostasis...
  2. pmc PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis
    Jennifer L Estall
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:22510-5. 2009
    b>FGF21 is a hormone produced in liver and fat that dramatically improves peripheral insulin sensitivity and lipid metabolism...
  3. pmc Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    Elayne Hondares
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
    Cell Metab 11:206-12. 2010
    Plasma FGF21 levels and hepatic FGF21 gene expression increase dramatically after birth in mice...
  4. pmc Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    Elayne Hondares
    Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, and CIBER Fisiopatologia de la Obesidad y Nutricion, 08028 Barcelona, Catalonia, Spain
    J Biol Chem 286:12983-90. 2011
    b>FGF21 is a novel metabolic regulator involved in the control of glucose homeostasis, insulin sensitivity, and ketogenesis. The liver has been considered the main site of production and release of FGF21 into the blood...
  5. ncbi FGF10 and FGF21 as regulators in adipocyte development and metabolism
    Hiroya Ohta
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Endocr Metab Immune Disord Drug Targets 11:302-9. 2011
    ..FGF10 and FGF21 play unique roles in adipocyte development and metabolism, respectively...
  6. pmc Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
    Ffolliott M Fisher
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Endocrinology 152:2996-3004. 2011
    Fibroblast growth factor (FGF21) plays an important role in regulating hepatic oxidation of fatty acids and gluconeogenesis in response to fasting and during consumption of a ketogenic diet...
  7. doi Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice
    Katsutaka Oishi
    Biological Clock Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 412:396-400. 2011
    b>Fibroblast growth factor 21 (FGF21) is a key metabolic regulator that is induced by fasting and starvation, and its expression is thought to be regulated by the circadian clock in the liver...
  8. pmc Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes
    Wei Chen
    Department of Geriatrics, Hua Shan Hospital, Fudan University, Shanghai 200040, China
    J Biol Chem 286:34559-66. 2011
    ..Here we demonstrate the existence of a feedback loop between GH and FGF21 on the regulation of lipolysis in adipocytes...
  9. doi Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet
    Takashi Uebanso
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    J Nutr Biochem 23:785-90. 2012
    ..Recent evidence has demonstrated that fibroblast growth factor 21 (FGF21) regulates hepatic lipolysis and fatty acid utilization...
  10. doi Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance
    Clarence Hale
    Department of Metabolic Disorders, Amgen Inc, MS 29 1 A, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Endocrinology 153:69-80. 2012
    Circulating levels of fibroblast growth factor 21 (FGF21), a metabolic regulator of glucose, lipid, and energy homeostasis, are elevated in obese diabetic subjects, raising questions about potential FGF21 resistance...
  11. pmc FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
    Ffolliott M Fisher
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Genes Dev 26:271-81. 2012
    ..We show here that fibroblast growth factor 21 (FGF21) plays a physiologic role in this thermogenic recruitment of WATs...
  12. pmc Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    Paul A Dutchak
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Cell 148:556-67. 2012
    Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects carbohydrate and lipid metabolism...
  13. ncbi Identification of a novel FGF, FGF-21, preferentially expressed in the liver
    T Nishimura
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Biochim Biophys Acta 1492:203-6. 2000
    ..Human FGF-21 is highly identical ( approximately 75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar ( approximately 35% amino acid identity) to FGF-19...
  14. doi Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice
    Rita Ann Kubicky
    Section of Endocrinology and Diabetes, St Christopher s Hospital For Children, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134, USA
    Endocrinology 153:2287-95. 2012
    ..The aim of this study was to determine whether the increased activity of fibroblast growth factor 21 (FGF21) during chronic undernutrition in mice causes GH insensitivity and growth failure...
  15. pmc Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB
    Chaofeng Yang
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas, United States of America
    PLoS ONE 7:e33870. 2012
    Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity and diabetes...
  16. pmc FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis
    Kenneth R Feingold
    Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    Endocrinology 153:2689-700. 2012
    ..b>Fibroblast growth factor 21 (FGF21) is a recently discovered hormone that regulates lipid and glucose metabolism and stimulates ..
  17. pmc Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LE
    Shufang Wu
    From the Section of Endocrinology and Diabetes, St Christopher s Hospital For Children, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134
    J Biol Chem 288:27375-83. 2013
    During calorie restriction in mice, increased expression of FGF21 causes growth attenuation and growth hormone (GH) insensitivity...
  18. pmc Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21
    Holly A Cyphert
    Department of Biochemistry, West Virginia University, Morgantown, West Virginia 26506, USA
    J Biol Chem 287:25123-38. 2012
    ..that starvation or consumption of a high fat, low carbohydrate (HF-LC) ketogenic diet induces hepatic fibroblast growth factor 21 (FGF21) gene expression in part by activating the peroxisome proliferator-activated receptor-α (PPARα)..
  19. pmc Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate
    Shufang Wu
    Department of Pediatrics, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134, USA
    J Biol Chem 287:26060-7. 2012
    b>Fibroblast growth factor 21 (FGF21) modulates glucose and lipid metabolism during fasting...
  20. pmc The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
    Yuan Zhang
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States
    elife 1:e00065. 2012
    Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response...
  21. doi Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
    Kook Hwan Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Nat Med 19:83-92. 2013
    ..by increased fatty acid oxidation and browning of white adipose tissue (WAT) owing to induction of fibroblast growth factor 21 (Fgf21)...
  22. pmc FGF21 requires βklotho to act in vivo
    Andrew C Adams
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA
    PLoS ONE 7:e49977. 2012
    b>FGF21 has gradually become a focal point in metabolic research given its intriguing and complex biology and relevance to drug discovery...
  23. doi Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model
    Xin Jiang
    Cancer Center at the First Hospital of Jilin University, Changchun 130021, China
    Toxicol Lett 219:65-76. 2013
    b>Fibroblast growth factor 21 (FGF21) is a novel member identified and was reported to express predominantly in pancreas, liver and adipose tissue, and relatively less in other organs, such as the testis...
  24. pmc Fibroblast growth factor 21 mediates specific glucagon actions
    Kirk M Habegger
    Metabolic Disease Institute, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 62:1453-63. 2013
    ..Notably, GcgR activation also raised hepatic expression and circulating levels of fibroblast growth factor 21 (FGF21)...
  25. doi The Klotho gene family as a regulator of endocrine fibroblast growth factors
    Hiroshi Kurosu
    Department of Hygiene and Public Health I, Tokyo Women s Medical University, 8 1, Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Mol Cell Endocrinol 299:72-8. 2009
    ..studies has shown that betaKlotho, a Klotho family protein, also functions as a cofactor required for FGF19 and FGF21 signaling and determines the tissue-specific metabolic activities of FGF19 and FGF21...
  26. ncbi Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    Michael K Badman
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Cell Metab 5:426-37. 2007
    ..Here, we identify liver-derived fibroblast growth factor 21 (FGF21) as an endocrine regulator of the ketotic state...
  27. ncbi PPARalpha is a key regulator of hepatic FGF21
    Thomas Lundåsen
    Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine, M63, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Biochem Biophys Res Commun 360:437-40. 2007
    The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity...
  28. pmc Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
    Hong Wang
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Cell Biol 28:188-200. 2008
    ..amino acid is also required for expression of a novel subset of adipocyte genes (group 2), including fibroblast growth factor 21 (FGF21), and that the FGF21 gene is a direct target of PPARgamma...
  29. ncbi FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho
    Alexei Kharitonenkov
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Cell Physiol 215:1-7. 2008
    ..All together, these results indicate that betaKlotho and FGFRs form the cognate FGF-21 receptor complex, mediating FGF-21 cellular specificity and physiological effects...
  30. doi betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c
    Masashi Suzuki
    Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Mol Endocrinol 22:1006-14. 2008
    ..BaF3 cells, which do not endogenously express any type of FGF receptor (FGFR) or heparan sulfate proteoglycan, FGF21 alone does not activate FGFRs and that betaKlotho is required for FGF21 to activate two specific FGFR subtypes: ..
  31. pmc Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 8:77-83. 2008
    ..In this report, we demonstrate that fibroblast growth factor 21 (FGF21), a hormone induced by fasting, causes GH resistance...
  32. pmc Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
    Michael K Badman
    Associate Professor of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Center for Life Sciences, 7th Floor, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 150:4931-40. 2009
    b>Fibroblast growth factor 21 (FGF21) is a key metabolic regulator...
  33. doi Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver
    Katsutaka Oishi
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    FEBS Lett 582:3639-42. 2008
    ..Recent studies have suggested that the expression of PPARalpha-dependent fibroblast growth factor 21 (FGF21) plays important roles in adaptation to fasting, such as lipolysis and ketogenesis...
  34. ncbi Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 5:415-25. 2007
    ..Here, we identify the endocrine hormone fibroblast growth factor 21 (FGF21) as a mediator of the pleiotropic actions of PPARalpha...
  35. pmc FGF21 is an Akt-regulated myokine
    Yasuhiro Izumiya
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, United States
    FEBS Lett 582:3805-10. 2008
    Fibroblast growth factor-21 (FGF21) functions as a metabolic regulator. The FGF21 transcript is reported to be abundantly expressed in liver, but little is known about the regulation of FGF21 expression in other tissues...
  36. pmc FGF-21 as a novel metabolic regulator
    Alexei Kharitonenkov
    Lilly Research Laboratories, Division of Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Invest 115:1627-35. 2005
    ..Thus, we conclude that FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes...
  37. doi Different roles of N- and C- termini in the functional activity of FGF21
    Radmila Micanovic
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Cell Physiol 219:227-34. 2009
    b>Fibroblast growth factor 21 is a member of endocrine FGFs subfamily, along with FGF19 and FGF23. It is emerging as a novel regulator with beneficial effects on a variety of metabolic parameters, including glucose and lipid control...
  38. pmc FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    Matthew J Potthoff
    Department of Pharmacology, Howard Hughes Medical Institute, Advanced Imaging Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:10853-8. 2009
    ..Here, we show that fibroblast growth factor 21 (FGF21), a hormone that is induced in liver by fasting, induces hepatic expression of peroxisome ..
  39. doi Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
    Yuhei Hotta
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Endocrinology 150:4625-33. 2009
    Fibroblast growth factors (Fgfs) are polypeptide growth factors with diverse functions. Fgf21, a unique member of the Fgf family, is expected to function as a metabolic regulator in an endocrine manner...
  40. pmc Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity
    Eric D Berglund
    Department of Molecular Physiology and Biophysics, National Institutes of Health Vanderbilt University Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocrinology 150:4084-93. 2009
    b>Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator shown to improve glycemic control...
  41. pmc A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption
    Xunde Wang
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 22:811-24. 2015
    b>Fibroblast growth factor 21 (FGF21) promotes insulin sensitivity but causes bone loss. It elevates bone resorption by an undefined non-osteoclast-autonomous mechanism...
  42. doi Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism
    Yori Ozaki
    1Department of Agricultural Chemistry, School of Agriculture, Meiji University, Kawasaki, Kanagawa 214 8571, Japan
    Br J Nutr 114:1410-8. 2015
    ..We identified the fibroblast growth factor 21 gene (Fgf21) as one of the most strongly up-regulated genes under conditions of acute protein ..
  43. doi Short-Term Curcumin Gavage Sensitizes Insulin Signaling in Dexamethasone-Treated C57BL/6 Mice
    Lili Tian
    Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, Canada Department of Medicine and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    J Nutr 145:2300-7. 2015
    ..Whether these occur only secondary to its chronic anti-inflammatory and antioxidative functions is unknown...
  44. pmc Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
    Chaofeng Yang
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A and M Health Science Center, 2121 W, Holcombe Blvd, Houston, TX 77030 3303, USA
    BMC Gastroenterol 13:67. 2013
    b>FGF21 is a promising intervention therapy for metabolic diseases as fatty liver, obesity and diabetes...
  45. pmc Expression of FGFs during early mouse tongue development
    Wen Du
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA 94143, USA
    Gene Expr Patterns 20:81-7. 2016
    ..Our results indicate that FGF signaling regulates tongue development at multiple stages. ..
  46. pmc Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
    Yun Hee Youm
    Section of Comparative Medicine and Program on Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, New Haven, CT 06520
    Proc Natl Acad Sci U S A 113:1026-31. 2016
    ..Here we show that the prolongevity ketogenic hormone fibroblast growth factor 21 (FGF21), a member of the endocrine FGF subfamily, is expressed in thymic stromal cells along with FGF ..
  47. doi Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy
    Yanli Cheng
    The First Hospital of Jilin University, Changchun 130021, China The Chinese American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, China Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Free Radic Biol Med 93:94-109. 2016
    ..FF also significantly increased fibroblast growth factor 21 (FGF21) expression and enhanced Nrf2 function in diabetic and non-diabetic kidneys...
  48. pmc Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2
    Thomas Laeger
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Cell Rep 16:707-16. 2016
    b>FGF21 contributes to the metabolic response to dietary protein restriction, and prior data implicate GCN2 as the amino acid sensor linking protein restriction to FGF21 induction...
  49. doi Physiology and Endocrinology Symposium: FGF21: Insights into mechanism of action from preclinical studies
    P J Antonellis
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285
    J Anim Sci 92:407-13. 2014
    b>Fibroblast growth factor 21 (FGF21) is a multifaceted metabolic regulator which has several potential applications in the treatment of metabolic disease...
  50. pmc Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR)
    Xingguo Cheng
    Department of Pharmaceutical Sciences, St John s University, 8000 Utopia Parkway, Queens, NY 11439, USA Electronic address
    Toxicol Appl Pharmacol 278:65-71. 2014
    ..The present study was performed to determine whether activation of the AhR induces Fgf21 expression. In mouse liver, TCDD increased Fgf21 mRNA in both dose- and time-dependent manners...
  51. ncbi Changes in FGF21 serum concentrations and liver mRNA expression in an experimental model of complete lipodystrophy and insulin-resistant diabetes
    A Špolcová
    Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic
    Physiol Res 63:483-90. 2014
    ..obesity and type 2 diabetes often display high levels of the anti-diabetic factor fibroblast growth factor-21 (FGF21), suggesting that the overproduction of FGF21 may result from increased adiposity in an attempt by white adipose ..
  52. pmc Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis
    Shan Jiang
    From the Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, and Shanghai Key Clinical Center for Metabolic Disease, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai 200233
    J Biol Chem 289:29751-65. 2014
    ..b>Fibroblast growth factor 21 (FGF21), a hormone that is predominantly secreted by the liver, exerts a broad range of effects upon ..
  53. doi Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress
    Seong Hun Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon ro, Gangnam Gu, Seoul, 135 710, South Korea
    Diabetologia 58:809-18. 2015
    b>Fibroblast growth factor 21 (FGF21) is an endocrine hormone that exhibits anti-diabetic and anti-obesity activity. FGF21 expression is increased in patients with and mouse models of obesity or nonalcoholic fatty liver disease (NAFLD)...
  54. doi Fibroblast growth factor 21 protects the heart from oxidative stress
    Anna Planavila
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona IBUB, Universitat de Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición CIBEROBN, Avda Diagonal 643, Barcelona 08028, Spain
    Cardiovasc Res 106:19-31. 2015
    ..We recently showed that fibroblast growth factor 21 (Fgf21) is produced by the heart and exerts protective effects, preventing cardiac hypertrophy ..
  55. doi FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism
    Yusuke Joki
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 459:124-30. 2015
    Ischemic heart disease is one of the leading causes of death. Fibroblast growth factor 21 (FGF21) is a circulating factor with an anti-diabetic property. Skeletal muscle is an important source of FGF21 production...
  56. doi Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21
    Julia M Assini
    Department of Vascular Biology J M A, E E M, A C B, B G S, D E T, S S C, C G S, M W H and Imaging Research Laboratories M D, Robarts Research Institute, London, Ontario, Canada N6A 5B7 Children s Health Research Institute and Departments of Paediatrics, Physiology and Pharmacology, and Oncology C L P Departments of Biochemistry J M A, E E M, A C B, S S C, M W H, Medical Biophysics M D and Medicine D E T, C G S, M W H, The University of Western Ontario, London, Ontario, Canada N6A 5B7 and Lilly Research Laboratories A C A, A K, Division of Eli Lilly and Company, Indianapolis, Indiana 46285
    Endocrinology 156:2087-102. 2015
    ..reduces dyslipidemia and improves glucose tolerance were investigated in C57BL6/J wild-type mice and fibroblast growth factor 21 (FGF21) null (Fgf21(-/-)) mice...
  57. doi Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1
    Ricardo J Samms
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Cell Rep 11:991-9. 2015
    A primary target of the pleiotropic metabolic hormone FGF21 is adipose tissue, where it initiates a gene expression program to enhance energy expenditure, an effect presumed to be centered on augmented UCP1 expression and activity...
  58. doi Ingestion of eicosapentaenoic acid in the early stage of social isolation reduces a fibroblast growth factor 21 resistant state independently of body weight in KKA(y) mice
    Katsunori Nonogaki
    Department of Diabetes Technology, Tohoku University, Graduate School of Biomedical Engineering, 6 6 11 Aramakiaza Aoba, Aoba ku, Sendai, Miyagi, 980 8579, Japan Electronic address
    Biochem Biophys Res Commun 464:674-7. 2015
    ..Although exogenous administration of FGF21 exerts beneficial effects on glucose and lipid metabolism, circulating FGF21 levels are elevated in ob/ob and db/..
  59. doi Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice
    Amena Archer
    Department of Biosciences and Nutrition and Center for Biosciences at NOVUM, Karolinska Institute, S 141 83 Huddinge, Sweden
    Mol Endocrinol 26:1980-90. 2012
    ..More recently fibroblast growth factor 21 (FGF21) has emerged as an important regulator of energy homeostasis...
  60. doi Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
    Zhuofeng Lin
    Institute of Metabolic Medicine, School of Pharmacology, Wenzhou Medical College, Wenzhou 325035, China
    Cell Metab 17:779-89. 2013
    b>Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on regulating glucose and lipid homeostasis and insulin sensitivity. However, the mechanisms underlying the metabolic actions of FGF21 remain unknown...
  61. pmc Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice
    Yu Li
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 288:10490-504. 2013
    ..The recently discovered fibroblast growth factor 21 (FGF21) is a hepatocyte-derived hormone that restores glucose and lipid homeostasis in obesity-induced ..
  62. pmc Autofluorescence imaging of living pancreatic islets reveals fibroblast growth factor-21 (FGF21)-induced metabolism
    Mark Y Sun
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Biophys J 103:2379-88. 2012
    Fibroblast growth factor-21 (FGF21) has therapeutic potential for metabolic syndrome due to positive effects on fatty acid metabolism in liver and white adipose tissue...
  63. doi Long-term high-fat diet links the regulation of the insulin-sensitizing fibroblast growth factor-21 and visfatin
    Bin Sun
    The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education, Chongqing Medical University, 400016 Chongqing, China
    Cytokine 59:131-7. 2012
    ..Both FGF-21 and visfatin expression and secretion are regulated by a potent regulator, long-term HFD. And these adipokines are associated with glucose-lipid metabolism and insulin resistance...
  64. pmc Dynamics and Distribution of Klothoβ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex
    Aaron Y K Ming
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
    J Biol Chem 287:19997-20006. 2012
    b>FGF21 stimulates FGFR1c activity in cells that co-express Klothoβ (KLB); however, relatively little is known about the interaction of these receptors at the plasma membrane...
  65. pmc Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein
    Xin Tong
    Department of Molecular and Integrative Physiology University of Michigan Medical School Ann Arbor, Michigan 48109, USA
    J Biol Chem 288:5417-25. 2013
    ..Fasting potently induces one of the key hepatic hormones, fibroblast growth factor 21 (FGF21), to promote lipolysis, fatty acid oxidation, and ketogenesis, whereas refeeding suppresses its ..
  66. doi The effects of fibroblast growth factor-21 knockdown and over-expression on its signaling pathway and glucose-lipid metabolism in vitro
    Ke Li
    Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China
    Mol Cell Endocrinol 348:21-6. 2012
    ..The aim of this study was to examine the effects of FGF-21 over- and underexpression on glucose and lipid metabolism in hepatocytes and adipocytes...
  67. doi Conjugated linoleic acid induces hepatic expression of fibroblast growth factor 21 through PPAR-α
    Jie Yu
    Animal Nutrition Institute, Sichuan Agricultural University, Ya an, Sichuan, China
    Br J Nutr 107:461-5. 2012
    b>Fibroblast growth factor 21 (FGF21) is a PPAR-α-regulated metabolic regulator that plays critical roles in glucose homoeostasis, lipid metabolism, insulin sensitivity and obesity...
  68. ncbi Expression of members of the Fgf family and their receptors during midfacial development
    M Bachler
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Mech Dev 100:313-6. 2001
    ..5. In contrast to the restricted expression patterns of the ligands, FgfR1 and FgfR2 were broadly expressed in facial mesenchyme and ectoderm, respectively, indicating a wide competence of midfacial tissue to respond to FGF signaling...
  69. ncbi Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development
    Mohammad K Hajihosseini
    School of Biosciences, The University of Birmingham, B15 2TT, UK
    Mech Dev 113:79-83. 2002
    ....
  70. ncbi Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development
    Tracy J Wright
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    Dev Dyn 228:267-72. 2003
    ..Fgf16 was expressed in the posterior otic cup and vesicle, suggesting roles in otic cell fate decisions and/or axis formation...
  71. ncbi Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse
    Hitomi Kurose
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, Minami Jyosanjima, Tokushima 770 8506, Japan
    Gene Expr Patterns 4:687-93. 2004
    ..Fgf15 is expressed in the optic vesicle, a subset of progenitor cells of neural retina, and emerging ganglion and amacrine cells during retinogenesis...
  72. ncbi Fine mapping of Dyscalc1, the major genetic determinant of dystrophic cardiac calcification in mice
    Susanne Korff
    Division of Cardiology, Department of Medicine III, University of Heidelberg, Heidelberg, Germany
    Physiol Genomics 25:387-92. 2006
    ..76 Mbp between genes Fgf21 (39.70 Mbp) and Myod1 (40.46 Mbp)...
  73. doi Glycosaminoglycan affinity of the complete fibroblast growth factor family
    Masahiro Asada
    Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8566, Japan
    Biochim Biophys Acta 1790:40-8. 2009
    ....
  74. pmc FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation
    Xinle Wu
    Amgen, Inc, South San Francisco, California 94080, USA
    J Biol Chem 285:5165-70. 2010
    FGF19 and FGF21, unique members of the fibroblast growth factor (FGF) family, are hormones that regulate glucose, lipid, and energy homeostasis...
  75. doi Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARalpha and FGF21 in mice with hepatic ablation of brain-derived neurotropic factor
    Sarah Teillon
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Endocrinol 205:37-47. 2010
    ..peroxisome proliferator-activated receptor alpha (Pparalpha or Ppara as listed in the MGI Database) and fibroblast growth factor 21 (Fgf21) transcripts compared with WTs...
  76. ncbi FGF21 is dispensable for hypothermia induced by fasting in mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Neuro Endocrinol Lett 31:198-202. 2010
    b>Fibroblast growth factor 21 (FGF21) is a key metabolic regulator that is induced by peroxisome proliferator-activated receptor alpha (PPARalpha) activation in response to fasting...
  77. pmc Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway
    Mary D L Chau
    Cardiovascular and Metabolism Disease Area, Novartis Institute for Biomedical Research, Inc, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:12553-8. 2010
    b>Fibroblast growth factor 21 (FGF21) has been identified as a potent metabolic regulator...
  78. pmc Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)
    Xinle Wu
    Amgen Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 107:14158-63. 2010
    FGF19 and FGF21 are distinctive members of the FGF family that function as endocrine hormones...
  79. pmc Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes
    Xuan Ge
    Department of Medicine, University of Hong Kong, Hong Kong, China
    J Biol Chem 286:34533-41. 2011
    b>Fibroblast growth factor 21 (FGF21) is a liver-secreted endocrine factor with multiple beneficial effects on obesity-related disorders. It enhances glucose uptake by inducing the expression of glucose transporter-1 (GLUT1) in adipocytes...
  80. pmc Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice
    Dionysios V Chartoumpekis
    Department of Internal Medicine, Division of Endocrinology, Medical School, University of Patras, Patras, Greece
    Diabetes 60:2465-73. 2011
    Obesity is characterized by chronic oxidative stress. Fibroblast growth factor 21 (FGF21) has recently been identified as a novel hormone that regulates metabolism...
  81. pmc Maternal microRNAs are essential for mouse zygotic development
    Fuchou Tang
    Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    Genes Dev 21:644-8. 2007
    ....